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Cost-effectiveness analysis of deep brain stimulation for the treatment of alcohol use disorder and alcoholic liver disease
IF 7.6 1区 医学 Q1 CLINICAL NEUROLOGY
Brain Stimulation
Pub Date : 2025-01-24 DOI: 10.1016/j.brs.2025.01.014
Oluwatofunmi A. Abiola , Collin M. Lehmann , Khaled Moussawi , Hawre Jalal

Background

Alcohol use disorder (AUD) is a major public health concern and cause of mortality and morbidity. Alcohol-associated liver disease (ALD) is a debilitating complication of AUD, mitigated by abstinence from alcohol use. Deep brain stimulation (DBS) is emerging as a potential treatment for AUD. However, its cost-effectiveness compared to the standard medical treatment is unclear.

Objective

To estimate the cost-effectiveness of DBS compared to medical management for patients with AUD and ALD.

Methods

We utilized a decision analytic model based on published literature to conduct a cost-effectiveness analysis of costs and health outcomes for DBS and medical management in patients with AUD and ALD. We also carried out a threshold analysis to determine the probability of success necessary for DBS to be cost-effective. Costs were measured in 2024 US dollars and effectiveness in quality-adjusted life years (QALYs). We used a time horizon of 1–2 years and adopted a societal perspective.

Results

Our results show that for AUD patients in general, DBS is not cost-effective at any DBS success rate. However, for advanced ALD patients, defined as fibrosis stage 3 or beyond DBS becomes cost-effective. For these patients, DBS is cost-effective over a two-year period at a $100,000 willingness-to-pay threshold at DBS success rates greater than 53 %. For advanced decompensated ALD patients, DBS is cost-effective over a one-year period at DBS success rate greater than 35 %.

Conclusion

Should it prove efficacious, DBS may be cost-effective for patients with AUD and ALD. Thus, future randomized controlled trials to evaluate its efficacy are warranted.
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引用次数: 0
Note of concern regarding the sources of scientific evidence used to justify the Reclassification of Non-Invasive Brain Stimulation (NIBS) Devices without an intended medical purpose into Class III
IF 7.6 1区 医学 Q1 CLINICAL NEUROLOGY
Brain Stimulation
Pub Date : 2025-01-21 DOI: 10.1016/j.brs.2025.01.012
Andrea Antal , Alexander T. Sack , Til Ole Bergmann , Jovana Bjekic , Saša R. Filipovic , Ana Ganho-Ávila , Vera Moliadze , Michael A. Nitsche , Simone Rossi , Teresa Schuhmann , Hartwig Siebner , Walter Paulus , Chris Baeken
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引用次数: 0
The ENIGMA-Neuromodulation working group – A mission statement enigma -神经调节工作组-使命声明。
IF 7.6 1区 医学 Q1 CLINICAL NEUROLOGY
Brain Stimulation
Pub Date : 2025-01-10 DOI: 10.1016/j.brs.2024.12.1477
Taylor P. Kuhn , Aprinda Indahlastari , Fidel Vila-Rodriguez , Gregory A. Fonzo
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引用次数: 0
Ultrasound neuromodulation – How deep can we stimulate? 超声神经调控--我们能刺激多深的神经？
IF 7.6 1区 医学 Q1 CLINICAL NEUROLOGY
Brain Stimulation
Pub Date : 2025-01-01 DOI: 10.1016/j.brs.2024.12.1189
Roland Beisteiner, Eva Matt
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引用次数: 0
The role of delta phase for temporal predictions investigated with bilateral parietal tACS 用双侧顶叶tACS研究delta相对时间预测的作用。
IF 7.6 1区 医学 Q1 CLINICAL NEUROLOGY
Brain Stimulation
Pub Date : 2025-01-01 DOI: 10.1016/j.brs.2024.12.1476
Rebecca Burke , Alexander Maÿe , Jonas Misselhorn , Marina Fiene , Felix J. Engelhardt , Till R. Schneider , Andreas K. Engel

Background

Previous research has shown that temporal prediction processes are associated with phase resets of low-frequency delta oscillations in a network of parietal, sensory and frontal areas during non-rhythmic sensory stimulation. Transcranial alternating current stimulation (tACS) modulates perceptually relevant brain oscillations in a frequency and phase-specific manner, allowing the assessment of their functional qualities in certain cognitive functions like temporal prediction.

Objective

We addressed the relation between oscillatory activity and temporal prediction by using tACS to manipulate brain activity in a sinusoidal manner. This enables the investigation of the relevance of low-frequency oscillations’ phase for temporal prediction.

Methods

Delta tACS was applied over the left and right parietal cortex in two separate unimodal and crossmodal temporal prediction experiments. Participants judged either the visual or the tactile reappearance of a uniformly moving visual stimulus, which shortly disappeared behind an occluder. tACS was applied with six different phase shifts relative to sensory stimulation in both experiments. Additionally, a computational model was developed and analysed to elucidate oscillation-based functional principles for the generation of temporal predictions.

Results

Only in the unimodal experiment, the application of delta tACS resulted in a phase-dependent modulation of temporal prediction performance. By considering the effect of sustained tACS in the computational model, we demonstrate that the entrained dynamics can phase-specifically modulate temporal prediction accuracy.

Conclusion

Our results suggest that delta oscillatory phase contributes to unimodal temporal prediction. Crossmodal prediction may involve a broader brain network or cross-frequency interactions, extending beyond parietal delta phase and the scope of our current stimulation design.
背景：先前的研究表明，在无节奏的感觉刺激下，时间预测过程与顶叶、感觉和额叶区域网络中的低频delta振荡的相位重置有关。经颅交流电刺激（tACS）以特定频率和相位的方式调节感知相关的大脑振荡，从而可以评估其在某些认知功能（如时间预测）中的功能质量。目的：我们通过使用tACS以正弦方式操纵大脑活动来研究振荡活动与时间预测之间的关系。这使得研究低频振荡相位与时间预测的相关性成为可能。方法：在左右顶叶皮层分别应用Delta tACS进行单峰和跨峰时间预测实验。参与者判断一个均匀移动的视觉刺激的视觉或触觉再现，这个视觉刺激很快消失在封堵物后面。在这两个实验中，tACS应用了六种不同的相对于感官刺激的相移。此外，还开发和分析了一个计算模型，以阐明基于振荡的功能原理，用于生成时间预测。结果：只有在单峰实验中，δ tACS的应用导致了时间预测性能的相位依赖调制。通过在计算模型中考虑持续tACS的影响，我们证明了夹带动力学可以相位特异性地调制时间预测精度。结论：我们的研究结果表明，delta振荡相位有助于单峰时间预测。跨模态预测可能涉及更广泛的大脑网络或跨频率相互作用，超出顶叶δ期和我们当前刺激设计的范围。
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引用次数: 0
Vestibular involvement in transcranial electrical stimulation: Body sway as a marker of unintended stimulation 经颅电刺激的前庭介入：身体摇摆作为非预期刺激的标志。
IF 7.6 1区 医学 Q1 CLINICAL NEUROLOGY
Brain Stimulation
Pub Date : 2025-01-01 DOI: 10.1016/j.brs.2024.12.1188
Ilkka Laakso , Janita Nissi, Otto Kangasmaa
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引用次数: 0
The importance of being in-sync: closed-loop EEG-rTMS for personalizing target engagement for treatment of MDD
IF 7.6 1区 医学 Q1 CLINICAL NEUROLOGY
Brain Stimulation
Pub Date : 2025-01-01 DOI: 10.1016/j.brs.2024.12.052
Paul Sajda
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引用次数: 0
Beta-Band Connectivity Alterations as a Predictor for SAINT Outcomes in Treatment-Resistant Depression
IF 7.6 1区 医学 Q1 CLINICAL NEUROLOGY
Brain Stimulation
Pub Date : 2025-01-01 DOI: 10.1016/j.brs.2024.12.047
Masataka Wada , Anna Chaiken , Derrick Buchanan , Jen Lissemore , Eleanor Cole , Claudia Tischler , Jackob Keynan , Cammie Rolle , Nolan Williams
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引用次数: 0
State-depended electric brain stimulation beyond the motor system
IF 7.6 1区 医学 Q1 CLINICAL NEUROLOGY
Brain Stimulation
Pub Date : 2025-01-01 DOI: 10.1016/j.brs.2024.12.044
Surjo Soekadar
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引用次数: 0
EEG and LFP evoked potentials as biomarkers for DBS programming in subthalamic nucleus deep brain stimulation for Parkinson’s disease
IF 7.6 1区 医学 Q1 CLINICAL NEUROLOGY
Brain Stimulation
Pub Date : 2025-01-01 DOI: 10.1016/j.brs.2024.12.067
Tine Van Bogaert , Jana Peeters , Alexandra Boogers , Till Dembek , Robin Gransier , Jan Wouters , Philippe De Vloo , Wim Vandenberghe , Bart Nuttin , Myles Mc Laughlin
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引用次数: 0
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