Brain Stimulation最新文献

英文中文

Basal forebrain activation improves working memory in senescent monkeys

IF 7.6 1区医学 Q1 CLINICAL NEUROLOGY

Brain Stimulation

Pub Date : 2025-02-07 DOI: 10.1016/j.brs.2025.02.002

Kendyl R. Pennington , Luca Debs , Sophia Chung , Janki Bava , Clément M. Garin , Fernando L. Vale , Sarah K. Bick , Dario J. Englot , Alvin V. Terry Jr. , Christos Constantinidis , David T. Blake

Brain aging contributes to cognitive decline and risk of dementia. Degeneration of the basal forebrain cholinergic system parallels these changes in aging, Alzheimer's dementia, Parkinson's dementia, and Lewy body dementia, and thus is a common element linked to executive function across the lifespan and in disease states. Here, we tested the potential of one-hour daily intermittent basal forebrain stimulation to improve cognition in senescent Rhesus monkeys, and its mechanisms of action. Stimulation in five animals improved working memory duration in each animal over 8–12 weeks, with peak improvements observed in the first four weeks. In an ensuing three month period without stimulation, improvements were retained. With additional stimulation, performance remained above baseline throughout the 15 months of the study. Studies with a cholinesterase inhibitor in five animals produced inconsistent improvements in behavior. One of five animals improved significantly. Manipulating the stimulation pattern demonstrated selectivity for both stimulation and recovery period duration in two animals. Brain stimulation led to acute increases in cerebrospinal fluid levels of tissue plasminogen activator, which is an activating element for two brain neurotrophins, Nerve Growth Factor (NGF) and Brain-Derived Growth Factor (BDNF), in four animals. Stimulation also led to improved glucose utilization in stimulated hemispheres relative to contralateral in three animals. Glucose utilization also consistently declines with aging and some dementias. Together, these findings suggest that intermittent stimulation of the nucleus basalis of Meynert improves executive function and reverses some aspects of brain aging.

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引用次数: 0

tDCS cranial nerve Co-stimulation: Unveiling brainstem pathways involved in trigeminal nerve direct current stimulation in rats

IF 7.6 1区医学 Q1 CLINICAL NEUROLOGY

Brain Stimulation

Pub Date : 2025-02-05 DOI: 10.1016/j.brs.2025.01.025

Alireza Majdi , Liyi Chen , Lars E. Larsen , Robrecht Raedt , Myles Mc Laughlin

Background

The effects of transcranial direct current stimulation (tDCS) are generally thought to result from the polarization of cortical neurons by the weak electric fields it creates. However, recent evidence suggests that some tDCS effects may be mediated through co-stimulation of peripheral or cranial nerves, particularly the trigeminal nerve (TN). The TN projects to key brainstem nuclei that regulate neurotransmitter release throughout the central nervous system, but the specific pathways involved are not yet well understood.

Methods

In this study, we examined the effects of acute transcutaneous TN direct current stimulation (TN-DCS) on tonic (i.e. mean spike rate) and phasic (number of bursts, spike rate per burst, burst duration, and inter-burst interval) activities while simultaneously recording single-neuron activity across three brainstem nuclei in rats: the locus coeruleus (LC; phasic and tonic activities), dorsal raphe nucleus (DRN; tonic activity), and median raphe nucleus (MnRN; tonic activity).

Results

TN-DCS significantly modulated tonic activity in the LC and DRN, with interactions between amplitude, polarity, and time affecting mean spike rates. It also influenced phasic activity in the LC, altering burst number, duration, and inter-burst intervals. In contrast, MnRN tonic activity was unchanged. Blocking TN with xylocaine eliminated the effects on tonic activity in both the LC and DRN.

Conclusions

These results suggest that tDCS may modulate the TN, altering DRN and LC activity. Differential changes in tonic and phasic LC activity highlight their roles in TN-DCS effects on the cortex. This research offers insights to improve tDCS efficacy and understanding. Keywords: tDCS; trigeminal nerve; locus coeruleus; Dorsal raphe nucleus; median raphe nucleus.

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引用次数: 0

Deep brain stimulation-entrained gamma oscillations in chronic home recordings in Parkinson's disease

IF 7.6 1区医学 Q1 CLINICAL NEUROLOGY

Brain Stimulation

Pub Date : 2025-02-01 DOI: 10.1016/j.brs.2025.01.011

Maria Olaru , Amelia Hahn , Maria Shcherbakova , Simon Little , Wolf-Julian Neumann , Reza Abbasi-Asl , Philip A. Starr

Background

In Parkinson's disease, invasive brain recordings show that dopaminergic medication can induce narrowband gamma rhythms in the motor cortex and subthalamic nucleus, which co-fluctuate with dyskinesia scores. Deep brain stimulation can entrain these gamma oscillations to a subharmonic stimulation frequency. However, the incidence of entrainment during chronic therapeutic stimulation, its relationship to the basal ganglia stimulation site, and its effect on dyskinesia remain unknown.

Objective

Determine whether the behavioral effects and statistical properties of levodopa-induced gamma oscillations are altered when entrained with deep brain stimulation.

Methods

We used a sensing-enabled deep brain stimulator system, attached to both motor cortex and subthalamic (n = 15) or pallidal (n = 5) leads, to record 993 h of multisite field potentials, with 656 h recorded prior to initiating stimulation. 13 subjects (20 hemispheres) with Parkinson's disease (1/13 female, mean age 59 ± 9 years) streamed data while at home on their usual antiparkinsonian medication. Recordings during stimulation occurred at least five months after initiating stimulation.

Results

Cortical entrained gamma oscillations were detected in 4/5 hemispheres undergoing pallidal stimulation and 12/15 hemispheres undergoing subthalamic stimulation. Entraining levodopa-induced gamma oscillations at either site reduced their prodyskinetic effects. Cortical entrained gamma oscillations had reduced variance in peak frequency, increased spectral power, and higher variance in spectral power than levodopa-induced gamma oscillations.

Conclusion

Stimulation-entrained gamma oscillations are functionally and physiologically distinct from levodopa-induced gamma oscillations that occur in the absence of deep brain stimulation. Understanding the discrepancies between types of gamma oscillations may improve programming protocols.

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引用次数: 0

Lesion in the path of current flow to target pericavitational and perilesional brain areas: Acute network-level tDCS findings in chronic aphasia using concurrent tDCS/fMRI

IF 7.6 1区医学 Q1 CLINICAL NEUROLOGY

Brain Stimulation

Pub Date : 2025-01-30 DOI: 10.1016/j.brs.2025.01.024

Venkatagiri Krishnamurthy , Serena E. Song , Lisa C. Krishnamurthy , Simone Renée Roberts , Joo H. Han , Amy D. Rodriguez , Samir R. Belagaje , Marcus Meinzer , Bruce A. Crosson

引用次数: 0

Vagal nerve stimulation dynamically alters anxiety-like behavior in rats

IF 7.6 1区医学 Q1 CLINICAL NEUROLOGY

Brain Stimulation

Pub Date : 2025-01-30 DOI: 10.1016/j.brs.2025.01.018

A.G. Butler , J.K. Bassi , A.A. Connelly , M.R. Melo , A.M. Allen , S.J. McDougall

Background

Electrical vagal nerve stimulation (VNS), at currents designed to target sensory, interoceptive neurons, decreases anxiety-like behavior.

Objective/Hypothesis

We hypothesized that different VNS current intensities would differentially alter anxiety-like behavior through the activation of distinct brainstem circuits.

Methods

Electrodes were implanted to stimulate the left vagus nerve and to record diaphragm muscle and electrocardiogram activity. The VNS current required to elicit the A-fiber-mediated Hering-Breuer Reflex (HBR) was determined for each animal. Based on this threshold, animals received either sham stimulation or VNS at 1.5 (mid-intensity VNS) or 3 (higher-intensity VNS) times the threshold for HBR activation. Anxiety-like behavior was assessed using the elevated plus maze, open field test, and novelty-suppressed feeding test. Additionally, a place preference assay determined whether VNS is rewarding or aversive. Finally, a c-Fos assay was performed to evaluate VNS-driven neuronal activation within the brainstem.

Results

Mid-intensity VNS reduced anxiety-like behavior in the elevated plus maze and open field test. Higher-intensity VNS was aversive during the place preference assay, confounding anxiety measures. Both intensities increased overall c-Fos expression in neurons within the nucleus of the solitary tract, but mid-intensity VNS specifically increased c-Fos expression in noradrenergic neurons within the nucleus of the solitary tract while decreasing it in the locus coeruleus. In contrast, higher-intensity VNS had no effect on c-Fos expression in noradrenergic neurons of either the nucleus of the solitary tract or locus coeruleus.

Conclusion

Delivery of VNS induced reproducible, current intensity-dependent, effects on anxiety-like and aversive behavior in rats.

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引用次数: 0

Does transcutaneous auricular vagus nerve stimulation alter pupil dilation? A living Bayesian meta-analysis

IF 7.6 1区医学 Q1 CLINICAL NEUROLOGY

Brain Stimulation

Pub Date : 2025-01-28 DOI: 10.1016/j.brs.2025.01.022

Ipek Pervaz , Lilly Thurn , Cecilia Vezzani , Luisa Kaluza , Anne Kühnel , Nils B. Kroemer

Background

Transcutaneous vagus nerve stimulation (tVNS) has emerged as a promising technique to modulate autonomic functions, and pupil dilation has been recognized as a promising biomarker for tVNS-induced monoaminergic release. Nevertheless, studies on the effectiveness of various tVNS protocols have produced heterogeneous results on pupil dilation to date.

Methods

Here, we synthesize the existing evidence and compare conventional (“continuous”) and pulsed stimulation protocols using a Bayesian meta-analysis. To maintain a living version, we developed a Shiny App with the possibility to incorporate newly published studies in the future. Based on a systematic review, we included 18 studies (N = 771) applying either conventional or pulsed stimulation protocols.

Results

Across studies, we found anecdotal evidence for the null hypothesis, showing that taVNS does not increase pupil size (g = 0.15, 95 % CI = [0.03, 0.27], BF₀₁ = 1.0). Separating studies according to conventional vs. pulsed protocols revealed that studies using pulsed taVNS provide strong evidence for the alternative hypothesis(g = 0.36, 95 % CI = [0.19, 0.53], BF₁₀ = 50.8) while conventional taVNS studies provide strong evidence for the null hypothesis (g = 0.002, CI = [-0.14, 0.14], BF₀₁ = 21.9).

Conclusion

Our meta-analysis highlights differential effects of conventional and pulsed taVNS protocols on pupil dilation. These findings underscore the relevance of taVNS protocols in optimizing its use for specific applications that may require modulation of tonic vs. phasic monoaminergic responses and might also help to gain mechanistic insights into potential therapeutic effects.

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引用次数: 0

The effects of pulse amplitude in electroconvulsive therapy on seizure threshold, seizure duration, and time to reorientation

IF 7.6 1区医学 Q1 CLINICAL NEUROLOGY

Brain Stimulation

Pub Date : 2025-01-28 DOI: 10.1016/j.brs.2025.01.023

Maya Hazimeh , Harold A. Sackeim , Ziad Nahas

引用次数: 0

Bayesian Optimization Of NeuroStimulation (BOONStim)

IF 7.6 1区医学 Q1 CLINICAL NEUROLOGY

Brain Stimulation

Pub Date : 2025-01-27 DOI: 10.1016/j.brs.2025.01.020

Lindsay D. Oliver , Jerrold Jeyachandra , Erin W. Dickie , Colin Hawco , Salim Mansour , Stephanie M. Hare , Robert W. Buchanan , Anil K. Malhotra , Daniel M. Blumberger , Zhi-De Deng , Aristotle N. Voineskos

引用次数: 0

High intensity transcranial altering current stimulation for cognitive dysfunction in schizophrenia: A pilot trial

IF 7.6 1区医学 Q1 CLINICAL NEUROLOGY

Brain Stimulation

Pub Date : 2025-01-27 DOI: 10.1016/j.brs.2025.01.021

Zifan You , Zhangyin He , Luyao Zou , Shanshan Chen , Jinsong Tang

引用次数: 0

Influence of coil orientation on the TMS-induced electric field within the clinically recommended brain region for major depressive disorder

IF 7.6 1区医学 Q1 CLINICAL NEUROLOGY

Brain Stimulation

Pub Date : 2025-01-26 DOI: 10.1016/j.brs.2025.01.017

JianKang Wu , He Wang , Jingna Jin , Xin Wang , Ying Li , Zhipeng Liu , Tao Yin

引用次数: 0

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