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Role of 123-Iobenguane Myocardial Scintigraphy in Predicting Short Term Left Ventricular Functional Recovery and Indication to ICD Implantation after Coronary Revascularization: A Work Hypothesis 123-Iobenguane心肌显像在预测冠状动脉血运重建术后短期左心室功能恢复和ICD植入指征中的作用:一个工作假设
Pub Date : 2015-08-10 DOI: 10.17554/j.issn.2309-6861.2015.02.80
Testa Marzia, Chauvie Stephane, Biggi Alberto, Terulla Alessandra, F. Mauro
AIM: 123I-Iobenguane myocardial scintigraphy (MIBG), which identifies sympathetic nervous system dysfunction, has been shown to be an effective predictor of sudden cardiac mortality in patient with congestive heart failure (CHF) and could be a useful instrument to early identify adverse clinical events. Methods: patients with CHF, a New York Heart Association classification (NYHA) of II or III and a left ventricular ejection fraction (LVEF) ≤ 35% were eligible for cardiac defibrillator (ICD) placement under current LVEF-based criteria in the guidelines. All patients listed for ICD underwent a MIBG before the implantation, in order to assess the prognostic value of an early cardiac MIBG to predict appropriate ICD indication. Results: 11 patients (100% males; age 65.1±8.9 years) with mean LVEF 29.1±4.9% entered the study. All patients had a coronary artery disease (CAD) treated by coronary artery bypass graft (CABG) in six cases, by a percutaneous coronary angioplasty (PTCA) in seven and both procedures in two patients. In all subjects the heart/mediastinum (H/M) ratio was calculated 35%. An ICD was implanted in six patients (54.5%). The sensitivity, specificity, postive and negative predictive value of an H/M ratio ≤ 1.25 at MIBG was calculated in 75%, 75%; 85,7%, 60%. Conclusion: MIBG might be a promising method for excluding a 3-month left ventricular functional recovery.
目的:123I-Iobenguane心肌显像(MIBG)可识别交感神经系统功能障碍,已被证明是充血性心力衰竭(CHF)患者心脏性猝死的有效预测指标,可能是早期识别不良临床事件的有用工具。方法:根据当前指南中基于LVEF的标准,纽约心脏协会分级(NYHA)为II或III且左心室射血分数(LVEF)≤35%的CHF患者有资格放置心脏除颤器(ICD)。所有列入ICD的患者在植入前都进行了MIBG检查,以评估早期心脏MIBG的预后价值,以预测适当的ICD适应症。结果:11例患者(100%男性;年龄65.1±8.9岁,平均LVEF 29.1±4.9%。所有患者均患有冠状动脉疾病(CAD),其中6例采用冠状动脉旁路移植术(CABG), 7例采用经皮冠状动脉成形术(PTCA), 2例采用两种方法。所有受试者心脏/纵隔(H/M)比值计算为35%。植入ICD 6例(54.5%)。H/M比值≤1.25对MIBG的敏感性、特异性、阳性预测值和阴性预测值分别为75%、75%;85年,7%,60%。结论:MIBG可能是排除3个月左心室功能恢复的一种有希望的方法。
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引用次数: 0
The Interplay of Aging, Aortic Stiffness and Blood Viscosity in Atherogenesis 衰老、主动脉硬度和血液粘度在动脉粥样硬化中的相互作用
Pub Date : 2015-08-10 DOI: 10.17554/J.ISSN.2309-6861.2015.02.77
G. Sloop, J. Weidman, L. Shecterle, J. Cyr
Normal aortic compliance allows cardiac output to be distributed throughout the cardiac cycle, resulting in lower peak blood velocity. Loss of compliance with aging, hypertension, and possibly other risk factors for atherosclerosis increases peak blood velocity, creating eddy currents in areas of changing vascular geometry, as well as creating adverse patterns of diastolic flow. In the resulting areas of low flow, increased blood viscosity creates the potential for thrombosis. Occlusive thrombi may cause death; parietal or mural thrombi may organize to form atherosclerotic plaques.
正常的主动脉顺应性可使心输出量分布于整个心脏周期,从而使血流速度峰值降低。随着年龄增长、高血压和其他可能的动脉粥样硬化风险因素的丧失,峰值血流速度增加,在改变血管几何形状的区域产生涡流,并产生不利的舒张期血流模式。在产生的低流量区域,增加的血液粘度产生血栓形成的可能性。闭塞性血栓可致死亡;壁层或壁层血栓可形成动脉粥样硬化斑块。
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引用次数: 11
Clinical Evaluation of Different Revascularization Strategies: Unlabelled Use 不同血运重建策略的临床评价:未标示使用
Pub Date : 2015-08-10 DOI: 10.17554/j.issn.2309-6861.2015.02.82
M. Quezada-Feijoó, A. Mangas, Carmen Rodríguez, E. Segura, Carmen Toro-Fernandez, C. Gamero, David Gómez-Villarejo, R. Toro
AIMS: Coronary diseases are the main cause of mortality in the West. Several factors may affect successful percutaneous revascularization, such as the type of stent used or the cardiovascular risk factors associated with the patient. The systolic function of the left ventricle has usually been disregarded in restenosis scores. Our aim is to evaluate restenosis while taking into account the kind of stent used and the systolic function of the left ventricle. METHODS: A prospective, observational and population study. A total of 209 patients with percutaneous revascularization were recruited between March 2011 and January 2013 and monitored every six months. Their clinical data was collected and transthoracic echocardiograms were performed. RESULTS: The average age was 67±11 years old, 64.6% were men. Regarding cardiovascular risk factors, 55.6% were diabetics, 84.2% had hypertension and 81.3% were dyslipemic. A combined revascularization strategy was more often used among the general population than in the diabetic subgroup. The diabetic patient subgroup received a larger number of drug-coated stents. The systolic function was present among 84% of the general population compared to 80% of the diabetic patient subgroup. Both the general population as well as the diabetic patient subgroup presented a significant decreased sistolic function of the left ventricle when the restenosis rate was greater (p<0.001 respectively). Similarly, we observe that there is a significant connection between the ejection fraction and the emergence of a new symptoms. CONCLUSION: The non-combined strategy was used more frequently in the diabetic population with the use of a superior drug-eluting stent Furthermore, systolic function evaluation stratifies the restenosis risk, especially in patients with a depressed ventricular function.
目的:冠状动脉疾病是西方死亡的主要原因。有几个因素可能影响经皮血管重建术的成功,如使用的支架类型或与患者相关的心血管危险因素。在再狭窄评分中,左心室的收缩功能通常被忽略。我们的目的是评估再狭窄,同时考虑支架的种类和左心室的收缩功能。方法:前瞻性、观察性和人群研究。2011年3月至2013年1月,共招募经皮血管重建术患者209例,每6个月监测一次。收集他们的临床资料并进行经胸超声心动图检查。结果:患者平均年龄67±11岁,男性占64.6%。在心血管危险因素方面,糖尿病患者占55.6%,高血压患者占84.2%,血脂异常患者占81.3%。联合血运重建策略在普通人群中比在糖尿病亚组中更常用。糖尿病患者亚组接受的药物涂层支架数量较多。84%的普通人群存在收缩功能,而80%的糖尿病患者亚组存在收缩功能。普通人群和糖尿病患者亚组在再狭窄发生率较高时左心室收缩功能明显下降(p<0.001)。同样,我们观察到在射血分数和新症状的出现之间有显著的联系。结论:非联合策略在使用优质药物洗脱支架的糖尿病人群中使用更频繁。此外,收缩功能评估对再狭窄风险分层,特别是在心室功能低下的患者中。
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引用次数: 0
Role of Myocardial Strain Imaging in Chemotherapy Related Cardiotoxicity 心肌应变显像在化疗相关心脏毒性中的作用
Pub Date : 2015-08-10 DOI: 10.17554/j.issn.2309-6861.2015.02.76
A. Ogunsua, Amartya Kundu, Amir Y. Shaikh
With an increase in the survival rate and longevity of cancer patients and rapid development of novel anti neoplastic agents, there have been growing concerns about the potential long-term side effects of these drugs. Cardiotoxicity resulting from targeted chemotherapy is a common adverse effect encountered in clinical practice. Traditionally, the cardiac side effects of chemotherapeutic agents have been evaluated primarily by measurement of reduction in systolic function of the heart by assessment of left ventricular ejection fraction (LVEF). Recently, there has been increasing emphasis on earlier and more accurate prediction of cardiotoxicity using imaging modalities besides evaluation of LVEF. Such methods include myocardial strain imaging. We present a review elaborating the role of myocardial strain imaging in chemotherapy related cardiotoxicity.
随着癌症患者生存率和寿命的提高以及新型抗肿瘤药物的快速发展,人们越来越关注这些药物潜在的长期副作用。靶向化疗引起的心脏毒性是临床上常见的不良反应。传统上,化疗药物的心脏副作用主要是通过评估左心室射血分数(LVEF)来测量心脏收缩功能的降低。近年来,除了评估LVEF外,越来越重视利用成像方式更早、更准确地预测心脏毒性。这些方法包括心肌应变成像。我们现就心肌应变成像在化疗相关心脏毒性中的作用作一综述。
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引用次数: 2
Impaired Phenotype of Circulating Endothelial-Derived Microparticles: Novel Marker of Cardiovascular Risk 循环内皮衍生微粒的表型受损:心血管风险的新标志物
Pub Date : 2015-08-10 DOI: 10.17554/J.ISSN.2309-6861.2015.02.78
A. Berezin
Circulating microparticles (MPs) delivered from the native cell membrane are suitable forms of cell-to-cell communication and transfer of biological active effectors. Circulating endothelial-derived MPs as a marker of endothelial dysfunction may discuss as integrated effectors interrelated target cells, endothelium, and conventional cardiovascualr risk factors. Endothelial-derived MPs play a pivotal role in vascular damage, integrity and tissue reparation. However, the role of MPs as biomarker of cardiovascular outcomes is required scrutinizes. The present review accumulates data regarding the role of circulating endothelial-derived MPs as novel marker of cardiovascular risk.
从天然细胞膜传递的循环微粒(MPs)是细胞间通信和生物活性效应物转移的合适形式。循环内皮源性MPs作为内皮功能障碍的标志物,可以作为靶细胞、内皮和传统心血管危险因素相关的综合效应物进行讨论。内皮来源的MPs在血管损伤、完整性和组织修复中起着关键作用。然而,MPs作为心血管预后的生物标志物的作用需要仔细研究。本综述收集了关于循环内皮源性MPs作为心血管风险新标志物作用的数据。
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引用次数: 35
Morphological Alterations of the Heart and Blood Vessels from Tobacco Smoke: the Steps of the Damage 烟草烟雾对心脏和血管的形态学改变:损害的步骤
Pub Date : 2015-08-10 DOI: 10.17554/j.issn.2309-6861.2015.02.81
A. Leone
Two cardiovascular structures are usually involved in the harm caused by cigarette smoke: myocardium and endothelium, which are mainly affected by carbon monoxide and nicotine. The harmful effects of smoking induce functional responses that eventually lead to morphological damage. With regard to the myocardium, three main steps have been well documented: myocardial alterations related to the hypoxia caused by increased concentrations in carboxyhemoglobin, reversible degenerative alterations of the cardiac muscle and irreversible myocardial necrosis. A typical experimental pattern due to smoking effects is the smoke cardiomyopathy. Endothelial dysfunction triggers a large number of responses, mainly consisting of blood and inflammatory cell migration and adhesion at the site of altered arterial wall,rupture of the muscular and elastic cells of the arterial wall and lipid infiltrates, which lead to atherosclerosis plaque. In addition, arteriosclerosis is the result of smoking on the resistance arteries. Evidence indicates that morphological alterations of the heart and blood vessels from smoking follow a well-defined way that allow us to tell the story of the cardiovascular alterations.
香烟烟雾的危害通常涉及两个心血管结构:心肌和内皮,它们主要受一氧化碳和尼古丁的影响。吸烟的有害影响诱导功能反应,最终导致形态损伤。关于心肌,有三个主要步骤已被充分记录:与碳氧血红蛋白浓度升高引起的缺氧有关的心肌改变,可逆的心肌退行性改变和不可逆的心肌坏死。吸烟引起的典型实验模式是烟雾性心肌病。内皮功能障碍引发大量的反应,主要包括血液和炎症细胞在动脉壁改变部位的迁移和粘附,动脉壁肌肉和弹性细胞的破裂和脂质浸润,从而导致动脉粥样硬化斑块的形成。此外,动脉硬化是吸烟对抵抗动脉的影响。有证据表明,吸烟对心脏和血管的形态学改变遵循一种明确的方式,这使我们能够讲述心血管改变的故事。
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引用次数: 4
The Concept of Functional Foods and Functional Farming (4 F) in the Prevention of Cardiovascular Diseases: A Review of Goals from 18th World Congress of Clinical Nutrition 功能食品的概念和功能农业在心血管疾病预防中的作用——第18届世界临床营养大会目标综述
Pub Date : 2015-08-10 DOI: 10.17554/j.issn.2309-6861.2015.02.75
Rb Singh, Toru Takahashi, S. Shastun, G. Elkilany, K. Hristova, A. Shehab, E. Onsaard, W. Phomkong, H. Chaves, Mukta Singh, Ratan K Srivastava, Munushi Srivastav, Rg Singh
The objectives of this communication are to make efforts which might ensure that the goals and targets for prevention set are adequate to address the many challenges of global malnutrition. These include both under-nutrition and obesity which are major risk factors of cardiovascular diseases (CVDs); hypertension, coronary artery disease (CAD, stroke and heart failure and other chronic diseases; type 2 diabetes mellitus, cancer, chronic respiratory diseases, bone and joint diseases and neurodegenerative diseases. We also find that this is an opportunity to develop an international consensus on how to approach the prevention of malnutrition, CVDs and other chronic diseases, so that there is no increase in human susceptibility to these diseases.
本通报的目的是作出努力,以确保制定的预防目标和指标足以应对全球营养不良的许多挑战。其中包括营养不良和肥胖,这是心血管疾病的主要危险因素;高血压、冠心病、中风和心力衰竭等慢性疾病;2型糖尿病、癌症、慢性呼吸系统疾病、骨关节疾病和神经退行性疾病。我们还发现,这是一个就如何预防营养不良、心血管疾病和其他慢性疾病达成国际共识的机会,这样人类对这些疾病的易感性就不会增加。
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引用次数: 10
A Massive Intake of Dabigatran: Case-Report and Short Review 大量摄入达比加群:病例报告和简短回顾
Pub Date : 2015-06-10 DOI: 10.17554/j.issn.2309-6861.2014.02.588
P. Moronval, Lorraine Legeleux, S. Thomann, J. Schved, J. Davy, F. Roubille
Objective: The toxicity profile of new oral anticoagulants is well established and with their increasing use the adverse events are frequently encountered in clinical practice. Here, we describe the haemostatic abnormalities after a massive ingestion of dabigatran. Case summary: A 69-year-old woman was admitted for suicidal attempt after ingestion of 9 grams of dabigatran (60 x 150mg pills), associated with 400 mg of nebivolol, 600 mg of diazepam and 1.5 grams of amitriptyline. The patient did not suffer from any bleeding events. Only few voluntary massive intakes are until now reported. Discussion: There are only few cases reporting such a massive voluntary intake of dabigatran leading to biological disorders contrasting with no clinically significant intake. This surprising absence of bleeding events in our case could be at least partly explained by the poor gastrointestinal intake of the drug, a functional gastroparesis, and a theoretically self-limiting biological effect. Conclusion: As no antidote is currently available in routine use for dabigatran, a systematic collection of cases of dabigatran toxicity provide an insight into the clinical manifestations and potential therapeutic implications.
目的:新型口服抗凝血剂的毒副作用已经确定,随着抗凝血剂使用的增加,其不良事件在临床实践中屡见不鲜。在这里,我们描述大量摄入达比加群后的止血异常。病例总结:一名69岁妇女在服用达比加群9g (60 × 150mg药片),同时服用奈比洛尔400mg、地西泮600mg和阿米替林1.5 g后,因企图自杀而入院。患者未发生任何出血事件。到目前为止,只有少数人自愿大量摄入。讨论:只有少数病例报告如此大量的自愿摄入达比加群导致生物学障碍,而没有临床显著的摄入。在我们的病例中,令人惊讶的没有出血事件至少可以部分解释为胃肠道对药物的摄入不良、功能性胃轻瘫和理论上自我限制的生物学效应。结论:由于达比加群目前没有解毒剂可用于常规使用,系统收集的达比加群毒性病例提供了临床表现和潜在治疗意义的见解。
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引用次数: 0
Giant Ascending Aortic Aneurysm Mimicking Acute Coronary Syndrome 模拟急性冠状动脉综合征的巨大升主动脉瘤
Pub Date : 2015-06-10 DOI: 10.17554/j.issn.2309-6861.2014.02.585
Mariama Akodad, T. Gandet, Y. Lounes, Corentin Curinier, F. Roubille
A 70-year-old patient was admitted in our center for acute coronary syndrome but investigations revealed a giant ascending aortic aneurysm without dissection. The patient was successfully treated with a Bentall procedure, usually challenging in the case of giant aneurysm, because of the risk of preoperative injury.
一位70岁的病人因急性冠状动脉综合征住进我中心,但检查发现一个巨大的升主动脉瘤,未剥离。由于术前有损伤的风险,本特尔手术对患者进行了成功的治疗。
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引用次数: 0
Systemic Lupus Erythematosus Presenting as Cardiac Tamponade Successfully Treated With High-Dose Steroid: A Case Report 大剂量类固醇成功治疗以心脏填塞为表现的系统性红斑狼疮1例
Pub Date : 2015-06-10 DOI: 10.17554/j.issn.2309-6861.2014.02.586
Mariama Akodad, M. Berous, B. Lattuca, Sébastien Jugant, F. Roubille
We report a case of a young woman with systemic lupus induced cardiac tamponade. After discussion with the cardiac surgeons’ team, medical management was decided and no pericardiocentesis was performed. Bolus of Methylprednisolon intravenously were administrated with a rapid improvement of the symptom and resolution of the pericardial effusion.
我们报告一例年轻妇女与系统性狼疮诱发心脏填塞。在与心脏外科医生团队讨论后,决定了医疗处理,没有进行心包穿刺。静脉给予甲泼尼松丸后,症状迅速改善,心包积液消失。
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引用次数: 0
期刊
Journal of clinical cardiology and cardiovascular therapy
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