Pub Date : 2022-03-08DOI: 10.1186/s13054-022-03929-x
Yu-Chin Kong, Yinjiao Ye, Jia-wei Ma, G. Shi
{"title":"Accuracy of heparin-binding protein for the diagnosis of nosocomial meningitis and ventriculitis","authors":"Yu-Chin Kong, Yinjiao Ye, Jia-wei Ma, G. Shi","doi":"10.1186/s13054-022-03929-x","DOIUrl":"https://doi.org/10.1186/s13054-022-03929-x","url":null,"abstract":"","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41456998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-03DOI: 10.1186/s13054-022-03931-3
Kirstine N la Cour, Nina C Andersen-Ranberg, Sarah Weihe, Lone M Poulsen, Camilla B Mortensen, Cilia K W Kjer, Marie O Collet, Stine Estrup, Ole Mathiesen
Background: Delirium is the most common cerebral dysfunction in the intensive care unit (ICU) and can be subdivided into a hypoactive, hyperactive, or mixed motor subtype based on the clinical manifestation. The aim of this review was to describe the distribution, pharmacological interventions, and outcomes of delirium motor subtypes in ICU patients.
Methods: This systematic scoping review was performed according to the PRISMA-ScR and Cochrane guidelines. We performed a systematic search in six major databases to identify relevant studies. A meta-regression analysis was performed where pooled estimates with 95% confidence intervals were computed by a random effect model.
Results: We included 131 studies comprising 13,902 delirious patients. There was a large between-study heterogeneity among studies, including differences in study design, setting, population, and outcome reporting. Hypoactive delirium was the most prevalent delirium motor subtype (50.3% [95% CI 46.0-54.7]), followed by mixed delirium (27.7% [95% CI 24.1-31.3]) and hyperactive delirium (22.7% [95% CI 19.0-26.5]). When comparing the delirium motor subtypes, patients with mixed delirium experienced the longest delirium duration, ICU and hospital length of stay, the highest ICU and hospital mortality, and more frequently received administration of specific agents (antipsychotics, α2-agonists, benzodiazepines, and propofol) during ICU stay. In studies with high average age for delirious patients (> 65 years), patients were more likely to experience hypoactive delirium.
Conclusions: Hypoactive delirium was the most prevalent motor subtype in critically ill patients. Mixed delirium had the worst outcomes in terms of delirium duration, length of stay, and mortality, and received more pharmacological interventions compared to other delirium motor subtypes. Few studies contributed to secondary outcomes; hence, these results should be interpreted with care. The large between-study heterogeneity suggests that a more standardized methodology in delirium research is warranted.
背景：谵妄是重症监护病房（ICU）最常见的脑功能障碍，根据临床表现可分为低动型、多动型或混合运动型。本综述的目的是描述ICU患者谵妄运动亚型的分布、药物干预和结局。方法：根据PRISMA-ScR和Cochrane指南进行系统的范围评价。我们在六个主要数据库中进行了系统检索，以确定相关研究。通过随机效应模型计算95%置信区间的汇总估计，进行meta回归分析。结果：我们纳入131项研究，包括13902名谵妄患者。研究之间存在较大的研究间异质性，包括研究设计、环境、人群和结果报告的差异。谵妄运动亚型以低活动性谵妄最为常见（50.3% [95% CI 46.0 ~ 54.7]），其次为混合性谵妄（27.7% [95% CI 24.1 ~ 31.3]）和多活动性谵妄（22.7% [95% CI 19.0 ~ 26.5]）。在比较谵妄运动亚型时，混合性谵妄患者谵妄持续时间最长，ICU和住院时间最长，ICU和住院死亡率最高，并且在ICU住院期间使用特定药物（抗精神病药物、α2激动剂、苯二氮卓类药物和异丙酚）的频率更高。在研究中，谵妄患者的平均年龄较高（约65岁），患者更容易出现低活动性谵妄。结论：低活动性谵妄是危重症患者最常见的运动亚型。混合性谵妄在谵妄持续时间、住院时间和死亡率方面的预后最差，与其他谵妄运动亚型相比，混合性谵妄接受了更多的药物干预。很少有研究对次要结局有贡献；因此，这些结果应该谨慎解释。研究间的巨大异质性表明，在谵妄研究中有必要采用更标准化的方法。
{"title":"Distribution of delirium motor subtypes in the intensive care unit: a systematic scoping review.","authors":"Kirstine N la Cour, Nina C Andersen-Ranberg, Sarah Weihe, Lone M Poulsen, Camilla B Mortensen, Cilia K W Kjer, Marie O Collet, Stine Estrup, Ole Mathiesen","doi":"10.1186/s13054-022-03931-3","DOIUrl":"10.1186/s13054-022-03931-3","url":null,"abstract":"<p><strong>Background: </strong>Delirium is the most common cerebral dysfunction in the intensive care unit (ICU) and can be subdivided into a hypoactive, hyperactive, or mixed motor subtype based on the clinical manifestation. The aim of this review was to describe the distribution, pharmacological interventions, and outcomes of delirium motor subtypes in ICU patients.</p><p><strong>Methods: </strong>This systematic scoping review was performed according to the PRISMA-ScR and Cochrane guidelines. We performed a systematic search in six major databases to identify relevant studies. A meta-regression analysis was performed where pooled estimates with 95% confidence intervals were computed by a random effect model.</p><p><strong>Results: </strong>We included 131 studies comprising 13,902 delirious patients. There was a large between-study heterogeneity among studies, including differences in study design, setting, population, and outcome reporting. Hypoactive delirium was the most prevalent delirium motor subtype (50.3% [95% CI 46.0-54.7]), followed by mixed delirium (27.7% [95% CI 24.1-31.3]) and hyperactive delirium (22.7% [95% CI 19.0-26.5]). When comparing the delirium motor subtypes, patients with mixed delirium experienced the longest delirium duration, ICU and hospital length of stay, the highest ICU and hospital mortality, and more frequently received administration of specific agents (antipsychotics, α2-agonists, benzodiazepines, and propofol) during ICU stay. In studies with high average age for delirious patients (> 65 years), patients were more likely to experience hypoactive delirium.</p><p><strong>Conclusions: </strong>Hypoactive delirium was the most prevalent motor subtype in critically ill patients. Mixed delirium had the worst outcomes in terms of delirium duration, length of stay, and mortality, and received more pharmacological interventions compared to other delirium motor subtypes. Few studies contributed to secondary outcomes; hence, these results should be interpreted with care. The large between-study heterogeneity suggests that a more standardized methodology in delirium research is warranted.</p>","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":"53"},"PeriodicalIF":0.0,"publicationDate":"2022-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8896322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43361878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-01DOI: 10.1186/s13054-022-03927-z
E. Kooistra, A. E. Van Herwaarden, J. Gerretsen, R. L. Smeets, S. van der Velde, M. V. D. Van Den Berg, J. G. van der Hoeven, M. Kox, P. Pickkers
{"title":"41st International Symposium on Intensive Care and Emergency Medicine","authors":"E. Kooistra, A. E. Van Herwaarden, J. Gerretsen, R. L. Smeets, S. van der Velde, M. V. D. Van Den Berg, J. G. van der Hoeven, M. Kox, P. Pickkers","doi":"10.1186/s13054-022-03927-z","DOIUrl":"https://doi.org/10.1186/s13054-022-03927-z","url":null,"abstract":"","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65772277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-28DOI: 10.1186/s13054-022-03901-9
H. Rüddel, D. Thomas-Rüddel, K. Reinhart, F. Bach, H. Gerlach, Matthias Lindner, J. Marshall, P. Simon, M. Weiss, F. Bloos, D. Schwarzkopf, Gernot Achim Tobias Heike Gunther Annett Steffen Christia Marx Schindler Schürholz Schlegel‑Höfner Lehmann S, G. Marx, Achim Schindler, T. Schürholz, Heike Schlegel‑Höfner, Gunther Lehmann, A. Sander, Steffen Friese, Christian Scholz, P. Fischer, C. Fuchs, L. Becher, Norbert Salewsky, T. Schreiber, A. Goldmann, D. Keh, K. Schmid, Winfried Menning, R. Steuckart, R. Barz, K. Dey, Meike Fahrenholz, Martin Müller, H. Gerlach, S. Toussaint, J. Brederlau, F. Bach, D. Buschmann, I. Gummelt, J. Hoeschen, M. Klaproth, I. Vedder, Ulrike Bachmann‑Holdau, J. Eiche, Rolf Hauschild, M. Lange, Davia Herrmann‑Karbaum, A. Lubasch, M. Rücker, C. Icke, Alexander Lucht, A. Meier‑Hellmann, Jan Wagner, Olaf Arnold, Steffen Kästner, T. Clausen, Michael Sternkopf, R. Voswinckel, T. Benndorf, Christel Eiserloh, G. Kuhnle, M. Koch, M. Gerber, M. Gründling, Liane Guderian, S. Kuhn, C. Scheer, G
{"title":"Adverse effects of delayed antimicrobial treatment and surgical source control in adults with sepsis: results of a planned secondary analysis of a cluster-randomized controlled trial","authors":"H. Rüddel, D. Thomas-Rüddel, K. Reinhart, F. Bach, H. Gerlach, Matthias Lindner, J. Marshall, P. Simon, M. Weiss, F. Bloos, D. Schwarzkopf, Gernot Achim Tobias Heike Gunther Annett Steffen Christia Marx Schindler Schürholz Schlegel‑Höfner Lehmann S, G. Marx, Achim Schindler, T. Schürholz, Heike Schlegel‑Höfner, Gunther Lehmann, A. Sander, Steffen Friese, Christian Scholz, P. Fischer, C. Fuchs, L. Becher, Norbert Salewsky, T. Schreiber, A. Goldmann, D. Keh, K. Schmid, Winfried Menning, R. Steuckart, R. Barz, K. Dey, Meike Fahrenholz, Martin Müller, H. Gerlach, S. Toussaint, J. Brederlau, F. Bach, D. Buschmann, I. Gummelt, J. Hoeschen, M. Klaproth, I. Vedder, Ulrike Bachmann‑Holdau, J. Eiche, Rolf Hauschild, M. Lange, Davia Herrmann‑Karbaum, A. Lubasch, M. Rücker, C. Icke, Alexander Lucht, A. Meier‑Hellmann, Jan Wagner, Olaf Arnold, Steffen Kästner, T. Clausen, Michael Sternkopf, R. Voswinckel, T. Benndorf, Christel Eiserloh, G. Kuhnle, M. Koch, M. Gerber, M. Gründling, Liane Guderian, S. Kuhn, C. Scheer, G","doi":"10.1186/s13054-022-03901-9","DOIUrl":"https://doi.org/10.1186/s13054-022-03901-9","url":null,"abstract":"","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42463298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-15DOI: 10.1186/s13054-022-04014-z
J. McPeake, P. Henderson, P. Mactavish, H. Devine, M. Daniel, Phil Lucie, Lynn Bollan, Lucy A Hogg, M. MacMahon, S. Mulhern, P. Murray, Laura O’Neill, L. Strachan, T. Iwashyna, M. Shaw, T. Quasim
{"title":"A multicentre evaluation exploring the impact of an integrated health and social care intervention for the caregivers of ICU survivors","authors":"J. McPeake, P. Henderson, P. Mactavish, H. Devine, M. Daniel, Phil Lucie, Lynn Bollan, Lucy A Hogg, M. MacMahon, S. Mulhern, P. Murray, Laura O’Neill, L. Strachan, T. Iwashyna, M. Shaw, T. Quasim","doi":"10.1186/s13054-022-04014-z","DOIUrl":"https://doi.org/10.1186/s13054-022-04014-z","url":null,"abstract":"","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42110204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-10DOI: 10.1186/s13054-022-03997-z
M. Matějovič, O. Huet, K. Dams, G. Elke, C. Vaquerizo Alonso, Á. Csomós, Ł. Krzych, R. Tetamo, Z. Puthucheary, O. Rooyackers, I. Tjäder, H. Kuechenhoff, W. Hartl, M. Hiesmayr
{"title":"Medical nutrition therapy and clinical outcomes in critically ill adults: a European multinational, prospective observational cohort study (EuroPN)","authors":"M. Matějovič, O. Huet, K. Dams, G. Elke, C. Vaquerizo Alonso, Á. Csomós, Ł. Krzych, R. Tetamo, Z. Puthucheary, O. Rooyackers, I. Tjäder, H. Kuechenhoff, W. Hartl, M. Hiesmayr","doi":"10.1186/s13054-022-03997-z","DOIUrl":"https://doi.org/10.1186/s13054-022-03997-z","url":null,"abstract":"","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48449943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-08DOI: 10.1186/s13054-022-03919-z
V. Ranieri, C. Guérin
{"title":"The physiological foundations of critical care medicine: the contribution of Joseph Milic-Emili, a physiologist “by hook or by crook”","authors":"V. Ranieri, C. Guérin","doi":"10.1186/s13054-022-03919-z","DOIUrl":"https://doi.org/10.1186/s13054-022-03919-z","url":null,"abstract":"","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44458789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-24DOI: 10.1186/s13054-022-03962-w
Nina Rittgerodt, T. Pape, M. Busch, L. Becker, A. Schneider, H. Wedemeyer, B. Seeliger, Julius J Schmidt, A. Hunkemöller, J. Fuge, W. Knitsch, C. Fegbeutel, Hans-Jörg Gillmann, B. Meyer, M. Hoeper, J. Hinrichs, S. David, K. Stahl
{"title":"Predictors of response to intra-arterial vasodilatory therapy of non-occlusive mesenteric ischemia in patients with severe shock: results from a prospective observational study","authors":"Nina Rittgerodt, T. Pape, M. Busch, L. Becker, A. Schneider, H. Wedemeyer, B. Seeliger, Julius J Schmidt, A. Hunkemöller, J. Fuge, W. Knitsch, C. Fegbeutel, Hans-Jörg Gillmann, B. Meyer, M. Hoeper, J. Hinrichs, S. David, K. Stahl","doi":"10.1186/s13054-022-03962-w","DOIUrl":"https://doi.org/10.1186/s13054-022-03962-w","url":null,"abstract":"","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49162086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-03DOI: 10.1186/s13054-022-03974-6
T. Hongo, Ryohei Yamamoto, Keibun Liu, Takahiko Yaguchi, Hisashi Dote, Ryusuke Saito, T. Masuyama, Kosuke Nakatsuka, S. Watanabe, Takahiro Kanaya, Tomoya Yamaguchi, T. Yumoto, H. Naito, A. Nakao
{"title":"Association between timing of speech and language therapy initiation and outcomes among post-extubation dysphagia patients: a multicenter retrospective cohort study","authors":"T. Hongo, Ryohei Yamamoto, Keibun Liu, Takahiko Yaguchi, Hisashi Dote, Ryusuke Saito, T. Masuyama, Kosuke Nakatsuka, S. Watanabe, Takahiro Kanaya, Tomoya Yamaguchi, T. Yumoto, H. Naito, A. Nakao","doi":"10.1186/s13054-022-03974-6","DOIUrl":"https://doi.org/10.1186/s13054-022-03974-6","url":null,"abstract":"","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43483546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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