Pub Date : 2022-04-11DOI: 10.1186/s13054-022-03981-7
F. Wen, Wen-Chi Chou, Chung-Chi Huang, Tsung-Hui Hu, Chiang Chu Ming, L. Chuang, S. Tang
{"title":"ICU bereaved surrogates’ comorbid psychological-distress states and their associations with prolonged grief disorder","authors":"F. Wen, Wen-Chi Chou, Chung-Chi Huang, Tsung-Hui Hu, Chiang Chu Ming, L. Chuang, S. Tang","doi":"10.1186/s13054-022-03981-7","DOIUrl":"https://doi.org/10.1186/s13054-022-03981-7","url":null,"abstract":"","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47293551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-08DOI: 10.1186/s13054-022-03964-8
C. Bruen, Mukhtar A Al-Saadi, E. Michelson, M. Tanios, Raul Mendoza-Ayala, Joseph Miller, Jeffrey Zhang, K. Stauderman, S. Hebbar, P. Hou
{"title":"Auxora vs. placebo for the treatment of patients with severe COVID-19 pneumonia: a randomized-controlled clinical trial","authors":"C. Bruen, Mukhtar A Al-Saadi, E. Michelson, M. Tanios, Raul Mendoza-Ayala, Joseph Miller, Jeffrey Zhang, K. Stauderman, S. Hebbar, P. Hou","doi":"10.1186/s13054-022-03964-8","DOIUrl":"https://doi.org/10.1186/s13054-022-03964-8","url":null,"abstract":"","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49308479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-08DOI: 10.1186/s13054-022-03975-5
M. Haaksma, J. Smit, A. Boussuges, A. Demoule, M. Dres, Giovanni Ferrari, P. Formenti, E. Goligher, L. Heunks, E. Lim, L. Mokkink, E. Soilemezi, Zhonghua Shi, M. Umbrello, L. Vetrugno, E. Vivier, Lei Xu, Massimo Zambon, P. Tuinman
{"title":"EXpert consensus On Diaphragm UltraSonography in the critically ill (EXODUS): a Delphi consensus statement on the measurement of diaphragm ultrasound-derived parameters in a critical care setting","authors":"M. Haaksma, J. Smit, A. Boussuges, A. Demoule, M. Dres, Giovanni Ferrari, P. Formenti, E. Goligher, L. Heunks, E. Lim, L. Mokkink, E. Soilemezi, Zhonghua Shi, M. Umbrello, L. Vetrugno, E. Vivier, Lei Xu, Massimo Zambon, P. Tuinman","doi":"10.1186/s13054-022-03975-5","DOIUrl":"https://doi.org/10.1186/s13054-022-03975-5","url":null,"abstract":"","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49467922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-08DOI: 10.1186/s13054-022-03953-x
Diogo Lopes, B. Chumbinho, João Pedro Bandovas, P. Faria, Catarina Espírito Santo, Bernardo Ferreira, Luis Val-Flores, Rui Pereira, N. Germano, L. Bento
{"title":"Pancreatic stone protein as a biomarker of sepsis","authors":"Diogo Lopes, B. Chumbinho, João Pedro Bandovas, P. Faria, Catarina Espírito Santo, Bernardo Ferreira, Luis Val-Flores, Rui Pereira, N. Germano, L. Bento","doi":"10.1186/s13054-022-03953-x","DOIUrl":"https://doi.org/10.1186/s13054-022-03953-x","url":null,"abstract":"","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46992224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-07DOI: 10.1186/s13054-022-03959-5
E. Trejnowska, Dominik Drobiński, P. Knapik, M. Wajda-Pokrontka, K. Szułdrzyński, Jakub Staromłyński, Wojciech Nowak, M. Urlik, M. Ochman, W. Goździk, W. Serednicki, J. Śmiechowicz, Jakub Brączkowski, W. Bąkowski, Anna Kwinta, M. Zembala, P. Suwalski
{"title":"Extracorporeal membrane oxygenation for severe COVID-19-associated acute respiratory distress syndrome in Poland: a multicenter cohort study","authors":"E. Trejnowska, Dominik Drobiński, P. Knapik, M. Wajda-Pokrontka, K. Szułdrzyński, Jakub Staromłyński, Wojciech Nowak, M. Urlik, M. Ochman, W. Goździk, W. Serednicki, J. Śmiechowicz, Jakub Brączkowski, W. Bąkowski, Anna Kwinta, M. Zembala, P. Suwalski","doi":"10.1186/s13054-022-03959-5","DOIUrl":"https://doi.org/10.1186/s13054-022-03959-5","url":null,"abstract":"","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43687251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-04DOI: 10.1186/s13054-022-03958-6
F. Thiolliére, C. Falandry, B. Allaouchiche, Victor Geoffray, L. Bitker, J. Reignier, Paul Abraham, S. Malaquin, Baptiste Balança, Hélène Boyer, P. Seguin, C. Guichon, M. Simon, A. Friggeri, C. Vacheron, Laurent Bernard Thomas Albrice Stanislas Remi Carole Bened Argaud Floccard Rimmele Levrat Ledechowski Bruyere, L. Argaud, B. Floccard, T. Rimmele, A. Levrat, Stanislas Ledechowski, R. Bruyère, C. Schwebel, Benedicte Zerr, Luc Jarrige, Q. Blanc, J. Morel, O. Baldési, G. Plantefeve, P. Seguin, C. Dahyot-fizelier, Michel Bonnivard, J. Roustan, S. Vimeux, A. Mofredj, S. Alaya, A. Maamar, J. Badie, B. Souweine, G. Choukroun, Oriane Fontaine, J. Constantin, Marc Gainier, B. Misset, J. Orban, J. Reignier, J. Doise, O. Millet, L. Favier, B. Jany, Ramin Ravan, D. Roux, P. Bertrand, N. Bèle, S. Malaquin, P. Guinot, J. Quenot, F. Bounes, C. Koubi, P. Danin
{"title":"Intensive care-related loss of quality of life and autonomy at 6 months post-discharge: Does COVID-19 really make things worse?","authors":"F. Thiolliére, C. Falandry, B. Allaouchiche, Victor Geoffray, L. Bitker, J. Reignier, Paul Abraham, S. Malaquin, Baptiste Balança, Hélène Boyer, P. Seguin, C. Guichon, M. Simon, A. Friggeri, C. Vacheron, Laurent Bernard Thomas Albrice Stanislas Remi Carole Bened Argaud Floccard Rimmele Levrat Ledechowski Bruyere, L. Argaud, B. Floccard, T. Rimmele, A. Levrat, Stanislas Ledechowski, R. Bruyère, C. Schwebel, Benedicte Zerr, Luc Jarrige, Q. Blanc, J. Morel, O. Baldési, G. Plantefeve, P. Seguin, C. Dahyot-fizelier, Michel Bonnivard, J. Roustan, S. Vimeux, A. Mofredj, S. Alaya, A. Maamar, J. Badie, B. Souweine, G. Choukroun, Oriane Fontaine, J. Constantin, Marc Gainier, B. Misset, J. Orban, J. Reignier, J. Doise, O. Millet, L. Favier, B. Jany, Ramin Ravan, D. Roux, P. Bertrand, N. Bèle, S. Malaquin, P. Guinot, J. Quenot, F. Bounes, C. Koubi, P. Danin","doi":"10.1186/s13054-022-03958-6","DOIUrl":"https://doi.org/10.1186/s13054-022-03958-6","url":null,"abstract":"","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46224722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-04DOI: 10.1186/s13054-022-03947-9
Sheng-Huei Wang, Kuang-Yao Yang, C. Sheu, Wei-Cheng Chen, M. Chan, Jia-Yih Feng, Chia-Min Chen, Biing-Ru Wu, Zhe-Rong Zheng, Yu-Ching Chou, C. Peng
{"title":"The necessity of a loading dose when prescribing intravenous colistin in critically ill patients with CRGNB-associated pneumonia: a multi-center observational study","authors":"Sheng-Huei Wang, Kuang-Yao Yang, C. Sheu, Wei-Cheng Chen, M. Chan, Jia-Yih Feng, Chia-Min Chen, Biing-Ru Wu, Zhe-Rong Zheng, Yu-Ching Chou, C. Peng","doi":"10.1186/s13054-022-03947-9","DOIUrl":"https://doi.org/10.1186/s13054-022-03947-9","url":null,"abstract":"","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45202712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-02DOI: 10.1186/s13054-022-03966-6
L. Camous, Jean-David Pommier, F. Martino, B. Tressières, A. Demoule, M. Valette
{"title":"Very late intubation in COVID-19 patients: a forgotten prognosis factor?","authors":"L. Camous, Jean-David Pommier, F. Martino, B. Tressières, A. Demoule, M. Valette","doi":"10.1186/s13054-022-03966-6","DOIUrl":"https://doi.org/10.1186/s13054-022-03966-6","url":null,"abstract":"","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47989670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-31DOI: 10.1186/s13054-022-03957-7
Marco Daverio, Florian von Borell, Anne-Sylvie Ramelet, Francesca Sperotto, Paula Pokorna, Sebastian Brenner, Maria Cristina Mondardini, Dick Tibboel, Angela Amigoni, Erwin Ista
Background: Management and monitoring of pain and sedation to reduce discomfort as well as side effects, such as over- and under-sedation, withdrawal syndrome and delirium, is an integral part of pediatric intensive care practice. However, the current state of management and monitoring of analgosedation across European pediatric intensive care units (PICUs) remains unknown. The aim of this survey was to describe current practices across European PICUs regarding the management and monitoring of pain and sedation.
Methods: An online survey was distributed among 357 European PICUs assessing demographic features, drug choices and dosing, as well as usage of instruments for monitoring pain and sedation. We also compared low- and high-volume PICUs practices. Responses were collected from January to April 2021.
Results: A total of 215 (60% response rate) PICUs from 27 European countries responded. Seventy-one percent of PICUs stated to use protocols for analgosedation management, more frequently in high-volume PICUs (77% vs 63%, p = 0.028). First-choice drug combination was an opioid with a benzodiazepine, namely fentanyl (51%) and midazolam (71%) being the preferred drugs. The starting doses differed between PICUs from 0.1 to 5 mcg/kg/h for fentanyl, and 0.01 to 0.5 mg/kg/h for midazolam. Daily assessment and documentation for pain (81%) and sedation (87%) was reported by most of the PICUs, using the preferred validated FLACC scale (54%) and the COMFORT Behavioural scale (48%), respectively. Both analgesia and sedation were mainly monitored by nurses (92% and 84%, respectively). Eighty-six percent of the responding PICUs stated to use neuromuscular blocking agents in some scenarios. Monitoring of paralysed patients was preferably done by observation of vital signs with electronic devices support.
Conclusions: This survey provides an overview of current analgosedation practices among European PICUs. Drugs of choice, dosing and assessment strategies were shown to differ widely. Further research and development of evidence-based guidelines for optimal drug dosing and analgosedation assessment are needed.
{"title":"Pain and sedation management and monitoring in pediatric intensive care units across Europe: an ESPNIC survey.","authors":"Marco Daverio, Florian von Borell, Anne-Sylvie Ramelet, Francesca Sperotto, Paula Pokorna, Sebastian Brenner, Maria Cristina Mondardini, Dick Tibboel, Angela Amigoni, Erwin Ista","doi":"10.1186/s13054-022-03957-7","DOIUrl":"10.1186/s13054-022-03957-7","url":null,"abstract":"<p><strong>Background: </strong>Management and monitoring of pain and sedation to reduce discomfort as well as side effects, such as over- and under-sedation, withdrawal syndrome and delirium, is an integral part of pediatric intensive care practice. However, the current state of management and monitoring of analgosedation across European pediatric intensive care units (PICUs) remains unknown. The aim of this survey was to describe current practices across European PICUs regarding the management and monitoring of pain and sedation.</p><p><strong>Methods: </strong>An online survey was distributed among 357 European PICUs assessing demographic features, drug choices and dosing, as well as usage of instruments for monitoring pain and sedation. We also compared low- and high-volume PICUs practices. Responses were collected from January to April 2021.</p><p><strong>Results: </strong>A total of 215 (60% response rate) PICUs from 27 European countries responded. Seventy-one percent of PICUs stated to use protocols for analgosedation management, more frequently in high-volume PICUs (77% vs 63%, p = 0.028). First-choice drug combination was an opioid with a benzodiazepine, namely fentanyl (51%) and midazolam (71%) being the preferred drugs. The starting doses differed between PICUs from 0.1 to 5 mcg/kg/h for fentanyl, and 0.01 to 0.5 mg/kg/h for midazolam. Daily assessment and documentation for pain (81%) and sedation (87%) was reported by most of the PICUs, using the preferred validated FLACC scale (54%) and the COMFORT Behavioural scale (48%), respectively. Both analgesia and sedation were mainly monitored by nurses (92% and 84%, respectively). Eighty-six percent of the responding PICUs stated to use neuromuscular blocking agents in some scenarios. Monitoring of paralysed patients was preferably done by observation of vital signs with electronic devices support.</p><p><strong>Conclusions: </strong>This survey provides an overview of current analgosedation practices among European PICUs. Drugs of choice, dosing and assessment strategies were shown to differ widely. Further research and development of evidence-based guidelines for optimal drug dosing and analgosedation assessment are needed.</p>","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":"88"},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41469292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-30DOI: 10.1186/s13054-022-03965-7
S. Muzaffar, S. Saran, S. Siddiqui
{"title":"Vitamin C therapy in septic shock","authors":"S. Muzaffar, S. Saran, S. Siddiqui","doi":"10.1186/s13054-022-03965-7","DOIUrl":"https://doi.org/10.1186/s13054-022-03965-7","url":null,"abstract":"","PeriodicalId":92888,"journal":{"name":"Critical care (Houten, Netherlands)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42918662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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