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Battle beyond Borders... Bows to Bravery and Brilliance 跨越国界的战斗……向勇敢和才华致敬
Pub Date : 2022-01-01 DOI: 10.1055/s-0042-1746419
Amandeep Kalra
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引用次数: 0
WINCARS: Looking to the Future, Working to Change the Past 展望未来,努力改变过去
Pub Date : 2022-01-01 DOI: 10.1055/s-0042-1754537
M. Mamas
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引用次数: 0
Himalayan Fibrillatory Waves in Juvenile Rheumatic Mitral Stenosis 幼年风湿性二尖瓣狭窄的喜马拉雅纤颤波
Pub Date : 2021-12-14 DOI: 10.1055/s-0041-1739128
Mohamed Kassim Akheela, A. Ahmed
An 18-year-old girl, a known case of rheumatic mitral stenosis, presented with dyspnea and palpitations. Electrocardiogram was done, which revealed atrial fibrillation and a large amplitude atrial fibrillatory wave, which was more than the voltage of R wave V1, a finding which is quite uncommon. Echocardiography revealed a large left atrium which was 80 mm in diameter. The patient was started on oral anticoagulation and referred for mitral valve replacement with maze procedure.
一个18岁的女孩,一个已知的病例风湿性二尖瓣狭窄,表现为呼吸困难和心悸。心电图示心房纤颤,心房纤颤波振幅较大,高于R波V1的电压,这是比较少见的。超声心动图显示左心房直径80毫米。患者开始口服抗凝治疗,转诊行迷宫手术二尖瓣置换术。
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引用次数: 0
High Risk of Venous Thrombosis Recurrence in Fully Anticoagulated Patient with Antithrombin Deficiency during COVID-19: A Case Report COVID-19期间抗凝酶缺乏患者充分抗凝后静脉血栓复发风险高1例
Pub Date : 2021-12-14 DOI: 10.1055/s-0041-1739129
M. Kovač, O. Markovic, Sanja Lalic-Cosic, G. Mitić
Coagulation dysfunction is a serious issue in patients with Coronavirus disease-19 (COVID-19). With regard to recently published studies, a high number of patients with acute respiratory distress syndrome (ARDS) secondary to COVID-19 developed life-threatening thrombotic complications despite anticoagulation. We report a case of young woman with the type-II heparin-binding site (HBS) antithrombin (AT) deficiency (Budapest 3-homozygous), who developed acute deep vein thrombosis on two occasions due to COVID-19 infection in the course of stable anticoagulation with vitamin K antagonist. The first thrombotic event was observed during mild COVID-19 infection, while the second thrombotic event she developed 2 months after she was negative for severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2). Our case highlights the complexity of the treatment in this particular type of thrombophilia and the need for precaution even in mild forms of viral infection. In the treatment of acute thrombosis, AT-deficient patients may benefit from the use of AT concentrate along with low-molecular weight heparin (LMWH), while in cases of type II-HBS, AT supplementation is mandatory.
凝血功能障碍是冠状病毒病-19 (COVID-19)患者的严重问题。根据最近发表的研究,尽管抗凝治疗,仍有大量继发于COVID-19的急性呼吸窘迫综合征(ARDS)患者出现危及生命的血栓性并发症。我们报告一例患有ii型肝素结合位点(HBS)抗凝血酶(AT)缺乏症(Budapest 3-纯合)的年轻女性,在使用维生素K拮抗剂稳定抗凝过程中,因COVID-19感染两次发生急性深静脉血栓形成。第一次血栓形成事件是在轻度COVID-19感染期间观察到的,而第二次血栓形成事件是在她对严重急性呼吸综合征冠状病毒-2 (SARS-CoV-2)呈阴性2个月后发生的。我们的病例强调了这种特殊类型的血栓性疾病治疗的复杂性,即使是轻微的病毒感染也需要预防。在急性血栓的治疗中,AT缺乏患者可能受益于AT浓缩物与低分子肝素(LMWH)的使用,而在ii型hbs病例中,AT补充是强制性的。
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引用次数: 2
Left Main Coronary Artery Spasm: Case Report 左主干冠状动脉痉挛1例
Pub Date : 2021-10-20 DOI: 10.1055/s-0041-1736247
Vijay Kumar Bodicherla, Srikrishna Srikakulapu, Lalitha Nemani
Abstract Vasospasm of coronary artery is a well-known cause for acute coronary syndrome (ACS) but left main coronary artery (LMCA) spasm is very rare. It may be iatrogenic or spontaneous. Here we report a case of a 44-year-old female who presented with chronic stable angina and experienced LMCA vasospasm while undergoing coronary angiography.
摘要冠状动脉血管痉挛是引起急性冠状动脉综合征(ACS)的常见原因,但左主干冠状动脉(LMCA)痉挛非常罕见。它可能是医源性的,也可能是自发的。在此,我们报告一位44岁的女性,她在接受冠状动脉造影时表现为慢性稳定型心绞痛和LMCA血管痉挛。
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引用次数: 1
Association between Endogenous Sex Hormones and Coronary Artery Disease in Postmenopausal Women 绝经后妇女内源性性激素与冠状动脉疾病的关系
Pub Date : 2021-10-20 DOI: 10.1055/s-0041-1736250
Roopali Khanna, Avinash Bansal, Sudeep Kumar, N. Garg, S. Tewari, A. Kapoor, P. Goel
Abstract Background Incidence of coronary artery disease (CAD) increases significantly in postmenopausal women, which is assumed to be an imbalance between serum androgen and estrogen levels. However, studies assessing serum sex hormones and CAD are few and have shown conflicting results. Objective To compare serum sex hormone levels and traditional risk factors among postmenopausal women with angiographically proven CAD and without CAD. Method The study included consecutive postmenopausal women undergoing coronary angiography in our institute from May 2016 to June 2017. The clinical and coronary angiographic data and traditional risk factors were assessed. Fasting serum levels of estradiol (E2), testosterone (T), sex hormone-binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEA-S), and insulin were measured. Results A total of 121 postmenopausal women were included in the study; 69 were CAD and 52 without CAD. Single-vessel disease was most common (55.1%), followed by double-vessel disease (24.6%) and triple-vessel disease (20.3%). Women with CAD had significantly lower estradiol/testosterone (E2/T) ratio (3.7 ± 2.6 vs. 5.4 ± 4.2, p = 0.008) compared with non-CAD group. SHBG, DHEA-S, and insulin levels were similar in CAD and non-CAD groups. The serum level of estradiol predicted the E2/T ratio (r = 0.316, p < 0.001) and positively associated with DHEA (r = 0.181, p = 0.047). Testosterone was negatively associated with E2/T ratio (r = – 0.682, p < 0.001). There was no significant correlation of estrogen, testosterone, or E2/T ratio to lipid profile (total cholesterol, HDL, LDL) in women with CAD. Conclusion E2/T ratio was significantly lowered in postmenopausal women with CAD. E2/T ratio may be a used a predictor of CAD in postmenopausal women Abstract Image
背景:绝经后妇女冠状动脉疾病(CAD)的发病率显著增加,这被认为是血清雄激素和雌激素水平失衡的结果。然而,评估血清性激素和CAD的研究很少,结果也相互矛盾。目的比较经血管造影证实的冠心病和非冠心病绝经后妇女血清性激素水平和传统危险因素。方法研究对象为2016年5月至2017年6月在我院连续行冠状动脉造影的绝经后妇女。评估临床和冠状动脉造影资料及传统危险因素。测定空腹血清雌二醇(E2)、睾酮(T)、性激素结合球蛋白(SHBG)、硫酸脱氢表雄酮(DHEA-S)和胰岛素水平。结果121名绝经后妇女纳入研究;冠心病69例,非冠心病52例。单支病变最常见(55.1%),其次为双支病变(24.6%)和三支病变(20.3%)。与非CAD组相比,CAD组女性雌二醇/睾酮(E2/T)比值显著降低(3.7±2.6 vs. 5.4±4.2,p = 0.008)。冠心病组和非冠心病组SHBG、DHEA-S和胰岛素水平相似。血清雌二醇水平预测E2/T比值(r = 0.316, p < 0.001),与DHEA呈正相关(r = 0.181, p = 0.047)。睾酮与E2/T比值呈负相关(r = - 0.682, p < 0.001)。CAD患者的雌激素、睾酮或E2/T比值与血脂(总胆固醇、HDL、LDL)无显著相关性。结论绝经后冠心病患者E2/T比值明显降低。E2/T比值可能是绝经后妇女CAD的一个预测指标
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引用次数: 1
Gender Differences in South Indians with Premature Coronary Artery Disease (< 40 Years)—Insights from the PCAD Registry 南印度过早冠状动脉疾病(< 40岁)的性别差异——来自PCAD登记处的见解
Pub Date : 2021-10-20 DOI: 10.1055/s-0041-1736249
L. Shetty, R. Patil, J. Kharge, J. Vijay Kumar, Santu Ghosh, C. Manjunath
Abstract Introduction Coronary artery disease (CAD) follows a different pattern in women and men, more so in the young (< 40 years). The gender differences in the risk factors, clinical presentation and diagnosis need to be understood, so that appropriate and timely treatment can be given. Objective The study contemplates to analyze the gender differences in the presence of major coronary risk factors, clinical presentation, diagnosis and immediate outcomes in patients who present with premature CAD (PCAD). Patients and Methods We evaluated 1,062 consecutive registry patients who presented with diagnosis of PCAD between 2018 to 2019 at our institution after satisfying the inclusion criteria. Results The study analyses 82 females and 980 males. The mean age of females was 35.4 ± 4.68 years and males was 34.2 ± 4.25 years. Males smoked more often (55.1%, p < 0.001). Females more often had abnormal BMI (84.1%, p < 0.001), increased waist-hip ratios (97.6%, p < 0.001), diabetes (35.4%, p < 0.001), dyslipidemia (17.1% vs. 11%) and hypertension (15.9% vs. 11.5%). STEMI was the most common presentation among males (80.4% vs. 71.9%). Majority of females (74.6%) presented 6 hours after index pain. NSTEMI was more common among females (20.7% vs. 16%). Single-vessel involvement was common in both sexes (84.1% in males and 85.2% in females). Obstructive CAD was less common in both groups. Conclusions Conventional risk factors play a major role for CAD in Indians. Smoking was common in males and metabolic syndrome in females. Also, females had a higher threshold for seeking treatment and referral. Measures have to be taken for early diagnosis and referral of females. Recanalized and thrombotic coronaries were common, indicating predominant thrombus burden in the young Abstract Image
冠状动脉疾病(CAD)在女性和男性中遵循不同的模式,在年轻人(< 40岁)中更是如此。需要了解危险因素、临床表现和诊断的性别差异,以便给予适当和及时的治疗。目的分析过早冠心病(PCAD)患者在主要冠状动脉危险因素、临床表现、诊断和预后方面的性别差异。患者和方法我们评估了2018年至2019年在我们机构连续登记的1062例诊断为PCAD的患者,这些患者在满足纳入标准后。结果女性82例,男性980例。女性平均年龄35.4±4.68岁,男性平均年龄34.2±4.25岁。男性吸烟较多(55.1%,p < 0.001)。女性多有BMI异常(84.1%,p < 0.001)、腰臀比增高(97.6%,p < 0.001)、糖尿病(35.4%,p < 0.001)、血脂异常(17.1%比11%)和高血压(15.9%比11.5%)。STEMI是男性中最常见的表现(80.4% vs. 71.9%)。大多数女性(74.6%)在指数疼痛后6小时出现。NSTEMI在女性中更为常见(20.7%对16%)。单支血管受累在两性中都很常见(男性84.1%,女性85.2%)。阻塞性CAD在两组中均较少见。结论传统危险因素在印度人冠心病发病中起主要作用。吸烟在男性中很常见,而代谢综合征在女性中很常见。此外,女性寻求治疗和转诊的门槛更高。必须采取措施对妇女进行早期诊断和转诊。再通和血栓性冠状动脉是常见的,表明主要的血栓负担在年轻
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引用次数: 1
Correlation between the Clinical Profile and Angiographic Severity of Coronary Artery Disease in ST Elevation Myocardial Infarction and Non-ST Elevation Myocardial Infarction Patients ST段抬高型心肌梗死与非ST段抬高型心肌梗死患者的临床特征与冠状动脉病变血管造影严重程度的相关性
Pub Date : 2021-10-20 DOI: 10.1055/s-0041-1736251
C. Swaminathan, P. Prasath
Abstract Background and Aim: The correlation between clinical profile and angiographic severity in acute coronary syndrome (ACS) patients has been poorly documented. Hence, the present study aimed to study the clinical profile and correlate that with vessel burden, as witnessed by coronary angiography, in patients presenting to the hospital with ACS (ST-segment elevation myocardial infarction [STEMI]/non-ST-segment elevation [NSTE]-ACS) Materials and Methods: The study had enrolled 209 patients who had been diagnosed with ACS. All subjects were those who presented to the Emergency Medicine Department in a tertiary care center (south India). Coronary angiogram done for these patients by cardiologists was reviewed with a SYNTAX CALCULATOR (I AND II). Patient's baseline characteristics and clinical examination and interventional diagnosis details were obtained. Results: The clinical profile gathered from this geographical territory implied an increase in the angiographic severity of the coronary artery disease as measured by the SYNTAX score 1, with an increase in the duration of the said risk factor. Male gender was predominant and the major age group for ACS was 30 to 60 years. The most common presentation in ACS was STEMI. Diabetes and hypertension were the main risk factors for ACS. There was a striking occurrence of ACS among the young. Conclusion: STEMI was the major ACS presentation in this study population. The main risk factors noted were diabetes and hypertension. Besides smoking and alcohol abuse (in any study population), dyslipidemia was also a key risk factor observed. Mild left ventricular systolic dysfunction was predominant in this study. The SYNTAX score 1 increased with duration of observed and recorded risk factors. Abstract Image
背景与目的:急性冠脉综合征(ACS)患者的临床表现与血管造影严重程度之间的相关性文献很少。因此,本研究旨在研究就诊的ACS (st段抬高型心肌梗死[STEMI]/非st段抬高型心肌梗死[NSTE]-ACS)患者的临床特征及其与冠脉造影所显示的血管负荷的相关性。所有受试者均为在三级保健中心(南印度)急诊医学部就诊的患者。用语法计算器(SYNTAX CALCULATOR, I AND II)对这些患者所做的冠状动脉造影进行回顾,获得患者的基线特征、临床检查和介入诊断细节。结果:从该地理区域收集的临床资料表明,SYNTAX评分为1的冠状动脉疾病的血管造影严重程度增加,上述风险因素的持续时间增加。ACS以男性为主,主要年龄在30 ~ 60岁。ACS中最常见的表现是STEMI。糖尿病和高血压是ACS的主要危险因素。ACS在年轻人中发病率很高。结论:STEMI是本研究人群中ACS的主要表现。主要的危险因素是糖尿病和高血压。除了吸烟和酗酒(在任何研究人群中),血脂异常也是观察到的一个关键危险因素。本研究以轻度左心室收缩功能不全为主。SYNTAX评分1随着观察和记录危险因素的持续时间而增加。抽象的形象
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引用次数: 1
Treatment of an Unyielding Central Vein Stenosis using Valvuloplasty Balloon in a Young Female Presenting with Ineffective Hemodialysis 用球囊瓣膜成形术治疗血液透析无效的年轻女性顽固性中心静脉狭窄
Pub Date : 2021-10-14 DOI: 10.1055/s-0041-1736440
A. Bhambhani, A. Joshi
Abstract Percutaneous balloon venoplasty is widely employed for the management of central vein stenosis (CVS), a condition frequently encountered in patients on maintenance hemodialysis (MHD). The hypertrophied and fibrotic venous stenotic lesions often pose a challenge for interventionists, due to resistance to dilatation and high-elastic recoil. We report here successful utilization of mitral valvuloplasty balloon for percutaneous treatment of an unyielding brachiocephalic vein stenosis. Repeated failure of conventionally used peripheral balloon dilatation catheter prompted the use of a mitral valvuloplasty balloon that could exert higher radial pressure while preventing melon-seeding and hence successfully achieve stenosis dilatation. The mitral valvuloplasty balloon can be effectively and safely used for lesions resistant to repeated dilatations by conventional peripheral balloons. Rheological stress on central veins from ipsilateral arteriovenous fistula (AVF) may result in development of stenotic lesions, even in the absence of prior venous catheterization of the affected vein; therefore, in the presence of relevant symptoms, this diagnosis should not be excluded on the basis of absence of prior direct trauma at the stenosis site.
经皮球囊静脉成形术广泛应用于维持性血液透析(MHD)患者中枢性静脉狭窄(CVS)的治疗。肥大和纤维化的静脉狭窄病变,由于其抵抗扩张和高弹性后坐力,常常对介入医师构成挑战。我们在此报告二尖瓣成形术球囊经皮治疗顽固性头臂静脉狭窄的成功应用。常规使用的外周球囊扩张导管多次失败,促使使用二尖瓣成形术球囊,该球囊可以施加更高的径向压力,同时防止瓜籽,从而成功地实现狭窄扩张。二尖瓣成形术球囊可有效、安全地用于常规外周球囊反复扩张的病变。同侧动静脉瘘(AVF)对中心静脉的流变应力可能导致狭窄病变的发展,即使没有事先对受影响的静脉进行静脉导管插入术;因此,在出现相关症状的情况下,不应以狭窄部位先前没有直接创伤为基础排除这种诊断。
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引用次数: 1
A Case Report of Ortner's Syndrome, Cardiovocal Hoarseness—An Infrequent Entity in the Contemporary World 奥特纳综合征,心声嘶哑-一个罕见的实体在当代世界报告1例
Pub Date : 2021-10-11 DOI: 10.1055/s-0041-1736254
K. Pranathi
Abstract Rheumatic fever (RF) and rheumatic valvular disease remain prevalent and are still significant health hazards in developing nations. Hoarseness of voice, although a common symptom in ENT, is a rare finding in cardiac patients. However, hoarseness of voice due to recurrent laryngeal nerve paralysis is an infrequent finding secondary to mitral stenosis. This case illustrates an unusual presentation of rheumatic heart disease (RHD) in young women. This case report highlights the importance of early reporting and diagnosis of RHD-RF, being very prevalent in developing nations and yet neglected.
风湿热(RF)和风湿性瓣膜病在发展中国家仍然普遍存在,并且仍然是重大的健康危害。声音嘶哑虽然是耳鼻喉科常见的症状,但在心脏病患者中却很少见。然而,由于喉返神经麻痹引起的声音嘶哑是二尖瓣狭窄的罕见继发发现。这个病例说明了一个不寻常的表现风湿性心脏病(RHD)在年轻女性。本病例报告强调了早期报告和诊断RHD-RF的重要性,RHD-RF在发展中国家非常普遍,但却被忽视。
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引用次数: 1
期刊
Indian journal of cardiovascular disease in women WINCARS
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