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Assessment of age-dependent sexual dimorphism in paediatric vertebral size and density using a statistical shape and statistical appearance modelling approach 使用统计形状和统计外观建模方法评估儿科脊椎尺寸和密度中与年龄相关的性双态性
IF 3.5 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-07 DOI: 10.1016/j.bone.2024.117251
Natalia M. Castoldi , Dermot O'Rourke , Maria Antico , Vittorio Sansalone , Laura Gregory , Peter Pivonka

This work focuses on the growth patterns of the human fourth lumbar vertebra (L4) in a paediatric population, with specific attention to sexual dimorphism. The study aims to understand morphological and density changes in the vertebrae through age-dependent statistical shape and statistical appearance models, which can describe full three-dimensional anatomy. Results show that the main growth patterns are associated with isotropic volumetric vertebral growth, a decrease in the relative size of the vertebral foramen, and an increase in the length of the transverse processes. Moreover, significant sexual dimorphism was demonstrated during puberty. We observe significant age and sex interaction in the anterior vertebral body height (P = 0.005), where females exhibited an earlier increase in rates of vertebral height evolution. Moreover, we also observe an increase in cross-sectional area (CSA) with age (P = 0.020), where the CSA is smaller in females than in males (significant sex effect P = 0.042). Finally, although no significant increase in trabecular bone density with age is observed (P = 0.363), a trend in the statistical appearance model suggests an increase in density with age.

这项研究的重点是人类第四腰椎(L4)在儿科人群中的生长模式,特别关注性别二态性。研究旨在通过与年龄相关的统计形状和统计外观模型来了解椎骨的形态和密度变化,这些模型可以描述完整的三维解剖结构。结果表明,主要的生长模式与各向同性的椎体体积增长、椎孔相对大小的减小以及横突长度的增加有关。此外,青春期还表现出明显的性别二态性。在椎体前部高度方面,我们观察到了明显的年龄和性别交互作用(P = 0.005),其中雌性的椎体高度进化率增长较早。此外,我们还观察到横截面积(CSA)随着年龄的增长而增加(P = 0.020),其中女性的横截面积小于男性(显著性别效应 P = 0.042)。最后,虽然没有观察到骨小梁密度随年龄的增长而明显增加(P = 0.363),但统计外观模型中的趋势表明密度会随着年龄的增长而增加。
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引用次数: 0
Global, regional and national trends in the burden of low bone mineral density from 1990 to 2030: A Bayesian age-period-cohort modeling study 1990 年至 2030 年全球、地区和国家低骨矿物质密度负担趋势:贝叶斯年龄-时期-队列模型研究。
IF 3.5 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-07 DOI: 10.1016/j.bone.2024.117253
Jiaying Li , Hongyu Jia , Zhenqiu Liu , Kelin Xu

Low bone mineral density (LBMD) remains a global public health concern. To provide deeper insights, we retrieved and calibrated LBMD death and Disability-Adjusted Life Years (DALYs) data from the Global Burden of Disease 2021 (GBD 2021) database. We calculated the age-standardized rate (ASR) and estimated annual percentage change (EAPC) to delineate LBMD trends across sexes, age groups, Sociodemographic Index (SDI) regions, and countries. Spearman rank order correlation analysis was used to explore the relationship between SDI and ASR. Additionally, we constructed Bayesian age-period-cohort (BAPC) models to predict future trends in LBMD up to 2030, with the mean absolute percentage error (MAPE) used to evaluate prediction accuracy. Our analyses revealed that global deaths related to LBMD nearly doubled, from 250,930 in 1990 to 463,010 in 2021, and are projected to rise to 473,690 by 2030. However, the ASR exhibited an opposite trend, decreasing from 17.91 per 100,000 in 1990 to 15.77 per 100,000 in 2021, and is expected to further decline to 13.64 per 100,000 by 2030. The EAPC indicated descending trends in 1990–2021 and 2022–2030. Trends in LBMD varied across different subgroups by sex, age, and location. Males are projected to continue experiencing higher death numbers than females, though the gap is narrowing. The 90 to 94 age group consistently had the highest ASR from 1990 to 2030. Lower SDI remains a critical factor contributing to the higher burden of LBMD. Spearman rank order correlation analysis showed a negative correlation between SDI and ASR. We categorized 6 distinct trends in ASR across different countries, with most expected to experience a decline by 2030. The MAPE value (0.038 < 0.1) indicated that the BAPC model produced reliable predictions even under the COVID-19 pandemic.

低骨矿物质密度(LBMD)仍然是一个全球公共卫生问题。为了提供更深入的见解,我们从《2021 年全球疾病负担》(GBD 2021)数据库中检索并校准了低骨密度死亡和残疾调整生命年(DALYs)数据。我们计算了年龄标准化比率 (ASR) 和估计年度百分比变化 (EAPC),以划分不同性别、年龄组、社会人口指数 (SDI) 地区和国家的 LBMD 趋势。我们使用斯皮尔曼秩相关分析来探讨 SDI 与 ASR 之间的关系。此外,我们还构建了贝叶斯年龄-时期-队列(BAPC)模型,以预测直到 2030 年的 LBMD 未来趋势,并用平均绝对百分比误差(MAPE)来评估预测的准确性。我们的分析表明,全球与肺结核相关的死亡人数几乎翻了一番,从 1990 年的 250,930 人增至 2021 年的 463,010 人,预计到 2030 年将增至 473,690 人。然而,ASR 却呈现出相反的趋势,从 1990 年的每 100,000 人中有 17.91 人死亡降至 2021 年的每 100,000 人中有 15.77 人死亡,预计到 2030 年将进一步降至每 100,000 人中有 13.64 人死亡。EAPC 表明 1990-2021 年和 2022-2030 年呈下降趋势。按性别、年龄和地点划分的不同亚群的 LBMD 趋势各不相同。预计男性的死亡人数将继续高于女性,但差距正在缩小。从 1990 年到 2030 年,90 至 94 岁年龄组的 ASR 一直最高。较低的 SDI 仍是导致更高的 LBMD 负担的关键因素。斯皮尔曼秩相关分析表明,SDI 与 ASR 之间呈负相关。我们对不同国家的 ASR 趋势进行了分类,其中大多数国家预计到 2030 年将出现下降。MAPE 值(0.038
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引用次数: 0
Sex-specific effects of a Mediterranean diet on lower limb bone strength in Polish children 地中海饮食对波兰儿童下肢骨强度的性别特异性影响。
IF 3.5 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-04 DOI: 10.1016/j.bone.2024.117252
Daria Masztalerz-Kozubek, Monika A. Zielinska-Pukos, Jadwiga Hamulka

Lifestyle factors have the potential to influence bone health in various ways, whether positively or negatively. As osteoporosis is believed to originate in early years, it is therefore essential to indicate factors that may positively affect bone health during childhood. The aim of our study was to investigate the effects of early and current diet, vitamin D supplementation, and BMI z-score on bone properties in a group of children aged 3–7 years. A cross-sectional sample of 205 preschoolers and their parents participated in the study. Dietary assessment was made using a modified version of the Polish-adapted Mediterranean Diet score (MVP-aMED) on the basis of the data from food frequency questionnaire (FFQ), filled out by the parents. Quantitative ultrasound (QUS) was used in the assessment of bone properties. In the sex-stratified analysis, significant associations were observed between MVP-aMED score (β = 0.193, 95 % CI: 0.005, 0.237; p = 0.04), BMI z-score (β = −0.318, 95 % CI: −1.455, −0.039; p = 0.04) and QUS z-score, exclusively among girls. After adjustment, only the relationship with diet remained significant (β = 0.209, 95 % CI: 0.007, 0.255; p = 0.04), suggesting that a higher adherence to the Mediterranean Diet may be associated with better bone properties in girls aged 3–7 years old. Our results emphasize the importance of fostering healthy dietary habits and maintaining proper weight in children in order to promote optimal bone development.

生活方式因素有可能以各种方式对骨骼健康产生积极或消极的影响。由于骨质疏松症被认为起源于幼年时期,因此有必要指出可能对儿童时期骨骼健康产生积极影响的因素。我们的研究旨在调查早期和当前饮食、维生素 D 补充剂以及体重指数 z 分数对 3-7 岁儿童骨骼特性的影响。共有 205 名学龄前儿童及其家长参与了这项横断面样本研究。根据家长填写的食物频率问卷(FFQ)数据,使用波兰改良版地中海饮食评分(MVP-aMED)进行饮食评估。定量超声(QUS)用于评估骨骼特性。在性别分层分析中,观察到 MVP-aMED 评分(β = 0.193,95 % CI:0.005,0.237;p = 0.04)、体重指数 z 评分(β = -0.318,95 % CI:-1.455,-0.039;p = 0.04)与 QUS z 评分之间存在显著关联,且仅限于女孩。经过调整后,只有与饮食的关系仍然显著(β = 0.209, 95 % CI: 0.007, 0.255; p = 0.04),这表明更多坚持地中海饮食可能与 3-7 岁女孩更好的骨骼特性有关。我们的研究结果表明,培养儿童健康的饮食习惯和保持适当的体重对促进骨骼的最佳发育非常重要。
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引用次数: 0
Microarchitectural analysis of the metacarpophalangeal joint using HR-pQCT in patients with rheumatoid arthritis: A comparison with healthy controls 使用 HR-pQCT 对类风湿性关节炎患者的掌指关节进行微结构分析:与健康对照组的比较。
IF 3.5 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-09-03 DOI: 10.1016/j.bone.2024.117250
Kounosuke Watanabe , Ko Chiba , Kazuteru Shiraishi , Takeshi Iida , Naoki Iwamoto , Akihiko Yonekura , Atsushi Kawakami , Makoto Osaki

Objective

To investigate which joint microarchitectural parameters measured by high-resolution peripheral quantitative computed tomography (HR-pQCT) serve as imaging markers for rheumatoid arthritis (RA).

Methods

The second and third metacarpophalangeal (MCP) joints of 50 patients with RA and 50 healthy controls (HCs) (aged 50–79 years, all females) were scanned using a HR-pQCT. Joint space, trabecular bone microarchitecture, and erosion were measured and compared between RA patients and HCs.

Results

There were no differences in joint space parameters between RA patients and HCs.

For bone microarchitecture, RA patients had lower trabecular bone mineral density (127 vs. 167 mg/cm3), thinner trabecular thickness (0.20 vs. 0.21 mm), fewer trabecular number (1.49 vs. 1.55 /mm), more rod-like structure (1.68 vs. 1.23), and poorer trabecular connectivity (4.51 vs. 5.72 /mm3) than HCs.

Regarding erosion, RA patients had a higher number of erosions per joint (36/100 vs. 18/100), larger volume (4.62 vs. 1.89 mm3), and longer width (2.40 vs. 1.82 mm) and longer length (2.34 vs. 1.64 mm) than HCs.

Most of the erosions in HCs were <5 mm3 in volume (95 %) and located on the radial side (85 %). When erosions <5 mm3 were compared between RA patients and HCs, there were no differences in their location or morphology.

Conclusions

Deterioration of bone microarchitecture and existences of erosions >5 mm3 in the MCP joints are sensitive imaging markers of RA. Erosions <5 mm3 in RA patients may include not only early pathological erosion but also physiological erosion because even HCs can have erosions <5 mm3.

目的:研究高分辨率外周定量计算机断层扫描(HR-pQCT)测量的哪些关节微结构参数可作为类风湿性关节炎(RA)的影像学标记:研究通过高分辨率外周定量计算机断层扫描(HR-pQCT)测量的哪些关节微结构参数可作为类风湿性关节炎(RA)的影像学标记:使用 HR-pQCT 扫描了 50 名 RA 患者和 50 名健康对照者(HCs)(年龄在 50-79 岁之间,均为女性)的第二和第三掌指关节(MCP)。对关节间隙、骨小梁微结构和侵蚀情况进行了测量,并对 RA 患者和 HCs 进行了比较:结果:RA 患者和 HCs 的关节间隙参数没有差异。在骨微结构方面,与 HCs 相比,RA 患者的骨小梁骨矿物质密度较低(127 vs. 167 mg/cm3),骨小梁厚度较薄(0.20 vs. 0.21 mm),骨小梁数量较少(1.49 vs. 1.55 /mm),杆状结构较多(1.68 vs. 1.23),骨小梁连接性较差(4.51 vs. 5.72 /mm3)。在侵蚀方面,RA 患者每个关节的侵蚀数量(36/100 对 18/100)、体积(4.62 对 1.89 mm3)、宽度(2.40 对 1.82 mm)和长度(2.34 对 1.64 mm)均高于 HC 患者。HCs 中的大多数糜烂体积为 3(95%),位于桡侧(85%)。当对RA患者和HC患者的侵蚀3进行比较时,其位置和形态均无差异:结论:骨微结构的恶化和 MCP 关节中大于 5 mm3 的侵蚀是 RA 的敏感影像学标志。RA患者的侵蚀3不仅包括早期病理侵蚀,还可能包括生理性侵蚀,因为即使是HCs也可能存在侵蚀3。
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引用次数: 0
Interaction of high lipogenic states with titanium on osteogenesis 高脂状态与钛对成骨的相互作用
IF 3.5 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-28 DOI: 10.1016/j.bone.2024.117242
T.S. Pinto , B.C. van der Eerden , M. Schreuders-Koedam , J. van de Peppel , I. Ayada , Q. Pan , M.M. Verstegen , L.J. van der Laan , G.M. Fuhler , W.F. Zambuzzi , M.P. Peppelenbosch

As obesity rates continue to rise, the prevalence of metabolic dysfunction and alcohol-associated steatotic liver disease (MetALD), a new term for Nonalcoholic Fatty Liver Disease (NAFLD), also increases. In an aging population, it is crucial to understand the interplay between metabolic disorders, such as MetALD, and bone health. This understanding becomes particularly significant in the context of implant osseointegration. This study introduces an in vitro model simulating high lipogenesis through the use of human Mesenchymal Stroma Cells-derived adipocytes, 3D intrahepatic cholangiocyte organoids (ICO), and Huh7 hepatocytes, to evaluate the endocrine influence on osteoblasts interacting with titanium. We observed a significant increase in intracellular fat accumulation in all three cell types, along with a corresponding elevation in metabolic gene expression compared to the control groups. Notably, osteoblasts undergoing mineralization in this high-lipogenesis environment also displayed lipid vesicle accumulation. The study further revealed that titanium surfaces modulate osteogenic gene expression and impact cell cycle progression, cell survival, and extracellular matrix remodeling under lipogenic conditions. These findings provide new insights into the challenges of implant integration in patients with obesity and MetALD, offering a deeper understanding of the metabolic influences on bone regeneration and implant success.

随着肥胖率的持续上升,代谢功能障碍和酒精相关性脂肪肝(MetALD)(非酒精性脂肪肝的新名称)的发病率也在增加。在老龄化人口中,了解代谢紊乱(如 MetALD)与骨骼健康之间的相互作用至关重要。这种认识对种植体骨结合尤为重要。本研究通过使用人间质基质细胞衍生的脂肪细胞、三维肝内胆管细胞器质(ICO)和 Huh7 肝细胞,引入了一个模拟高脂生成的体外模型,以评估内分泌对与钛相互作用的成骨细胞的影响。与对照组相比,我们观察到所有三种细胞类型的细胞内脂肪积累都明显增加,代谢基因表达也相应升高。值得注意的是,在这种高脂质生成环境中进行矿化的成骨细胞也显示出脂质囊泡的积累。研究进一步揭示,在脂质生成条件下,钛表面会调节成骨基因表达,影响细胞周期进展、细胞存活和细胞外基质重塑。这些发现为肥胖症和 MetALD 患者种植体整合所面临的挑战提供了新的见解,使人们对骨质再生和种植体成功的代谢影响有了更深入的了解。
{"title":"Interaction of high lipogenic states with titanium on osteogenesis","authors":"T.S. Pinto ,&nbsp;B.C. van der Eerden ,&nbsp;M. Schreuders-Koedam ,&nbsp;J. van de Peppel ,&nbsp;I. Ayada ,&nbsp;Q. Pan ,&nbsp;M.M. Verstegen ,&nbsp;L.J. van der Laan ,&nbsp;G.M. Fuhler ,&nbsp;W.F. Zambuzzi ,&nbsp;M.P. Peppelenbosch","doi":"10.1016/j.bone.2024.117242","DOIUrl":"10.1016/j.bone.2024.117242","url":null,"abstract":"<div><p>As obesity rates continue to rise, the prevalence of metabolic dysfunction and alcohol-associated steatotic liver disease (MetALD), a new term for Nonalcoholic Fatty Liver Disease (NAFLD), also increases. In an aging population, it is crucial to understand the interplay between metabolic disorders, such as MetALD, and bone health. This understanding becomes particularly significant in the context of implant osseointegration. This study introduces an <em>in vitro</em> model simulating high lipogenesis through the use of human Mesenchymal Stroma Cells-derived adipocytes, 3D intrahepatic cholangiocyte organoids (ICO), and Huh7 hepatocytes, to evaluate the endocrine influence on osteoblasts interacting with titanium. We observed a significant increase in intracellular fat accumulation in all three cell types, along with a corresponding elevation in metabolic gene expression compared to the control groups. Notably, osteoblasts undergoing mineralization in this high-lipogenesis environment also displayed lipid vesicle accumulation. The study further revealed that titanium surfaces modulate osteogenic gene expression and impact cell cycle progression, cell survival, and extracellular matrix remodeling under lipogenic conditions. These findings provide new insights into the challenges of implant integration in patients with obesity and MetALD, offering a deeper understanding of the metabolic influences on bone regeneration and implant success.</p></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142089667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between changes in serum bone metabolism markers and bone microarchitecture changes during basic combat training – The ARMI study 基础作战训练期间血清骨代谢标志物的变化与骨微结构变化之间的关联--ARMI 研究。
IF 3.5 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-23 DOI: 10.1016/j.bone.2024.117241
Jennifer C. Coulombe , Brittany N. Bozzini , Katelyn I. Guerriere , Stephen A. Foulis , Marinaliz Reynoso , Leila A. Walker , Jeffery S. Staab , Mary L. Bouxsein , Julie M. Hughes , Kristin L. Popp

Importance

U.S. Army Basic Combat Training (BCT) improves tibial volumetric bone mineral density (BMD) and structure in most, but not all soldiers. Few studies have investigated whether changes in serum bone biomarkers during BCT are associated with changes in tibial BMD and bone structure following BCT.

Objective

To characterize bone biomarker changes during BCT and to investigate the relationship between changes in bone biomarkers and changes in tibial BMD and bone structure.

Methods

We enrolled 235 trainees entering BCT in this ten-week prospective observational study. Trainees provided fasted blood samples and questionnaires weekly throughout BCT. Procollagen type 1 N-terminal propeptide (PINP) and C-terminal telopeptide of type 1 collagen (CTX) were measured by enzyme-linked immunoabsorbent assays every two weeks during BCT. We evaluated body composition and mass via dual-energy X-ray absorptiometry and bone structure, microarchitecture, and mineral density at the distal tibia via high-resolution peripheral quantitative computed tomography at baseline and post-BCT.

Results

Both male (n = 110) and female trainees (n = 125) were young (20.9 ± 3.7 and 20.7 ± 4.3 years, respectively), with normal to overweight BMIs (25.2 ± 4.1 and 24.2 ± 3.6 kg/m2, respectively). In female trainees, PINP increased during and post-BCT compared to baseline, with the greatest increase in PINP at week four (45.4 % ± 49.6, p < 0.0001), whereas there were no changes in CTX. PINP also increased in male trainees, but only at weeks two and four (21.9 % ± 24.5, p = 0.0027 and 35.9 % ± 35.8, p < 0.0001, respectively). Unlike female trainees, in males, CTX was lower than baseline at weeks four, eight, and post-BCT. The change in PINP from baseline to week four of BCT was positively associated with changes in tibial BMD, Tb.BMD, Tb.Th, Tb.BV/TV, Ct.Th, Ct.Ar, and Ct.Po from the baseline to post-BCT.

Conclusion

The bone formation marker PINP increases during U.S. Army BCT, especially during the first four weeks. Increases in PINP, but not CTX, were correlated with improved BMD and bone structure in the distal tibia.

重要性:美国陆军基础战斗训练(BCT)可改善大多数士兵的胫骨体积骨矿物质密度(BMD)和结构,但并非所有士兵都能做到这一点。很少有研究调查 BCT 期间血清骨生物标志物的变化是否与 BCT 后胫骨 BMD 和骨结构的变化有关:描述 BCT 期间骨生物标志物的变化特征,并研究骨生物标志物的变化与胫骨 BMD 和骨结构变化之间的关系:我们在这项为期十周的前瞻性观察研究中招募了 235 名进入 BCT 的学员。在整个 BCT 期间,学员每周提供空腹血液样本和问卷调查。在 BCT 期间,每两周通过酶联免疫吸附试验测量一次 1 型胶原 N 端前肽(PINP)和 1 型胶原 C 端端肽(CTX)。我们通过双能 X 射线吸收测定法评估了身体成分和质量,并通过高分辨率外周定量计算机断层扫描评估了基线和 BCT 后胫骨远端的骨结构、微结构和矿物质密度:男性学员(n = 110)和女性学员(n = 125)都很年轻(分别为 20.9 ± 3.7 岁和 20.7 ± 4.3 岁),体重指数从正常到超重(分别为 25.2 ± 4.1 千克/平方米和 24.2 ± 3.6 千克/平方米)。在女性学员中,与基线相比,PINP 在 BCT 期间和 BCT 后均有所增加,其中第四周的增幅最大(45.4 % ± 49.6,p 结论:PINP 在 BCT 期间和 BCT 后均有所增加:骨形成标志物 PINP 在美国陆军 BCT 期间会增加,尤其是在前四周。PINP 的增加与胫骨远端 BMD 和骨结构的改善有关,而 CTX 的增加与之无关。
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引用次数: 0
Effects of cluster set resistance training on bone mineral density and markers of bone metabolism in older hemodialysis subjects: A pilot study 集群阻力训练对老年血液透析受试者骨矿物质密度和骨代谢指标的影响:一项试点研究。
IF 3.5 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-23 DOI: 10.1016/j.bone.2024.117240
Bruno Magalhães de Castro , Thiago dos Santos Rosa , Thaís Branquinho de Araújo , Hugo de Luca Corrêa , Lysleine Alves de Deus , Rodrigo Vanerson Passos Neves , Andrea Lucena Reis , Rafael Lavarini dos Santos , Jéssica Mycaelle da Silva Barbosa , Fernando de Sousa Honorato , Vitória Marra da Motta Vilalva Mestrinho , Milton Rocha de Moraes , Carmen Tzanno-Martins , Jonato Prestes

Chronic kidney disease (CKD) is associated with a series of mineral bone disturbances due to increased production of parathormone which increases the activity of osteoclasts, removing calcium and phosphorous from the bones. However, the literature lacks investigations on the feasibility of different resistance training (RT) methods, such as cluster-sets, in this population. Thus, the aim of the present study was to compare traditional versus cluster-set RT protocols on bone mineral density (BMD) T-score, BMD Total, femur BMD, L3-L4 BMD, femoral neck BMD, Klotho, FGF23, Klotho - FGF23 ratio, Sclerostin, vitamin D, phosphorous and calcium in older subjects with CKD. Seventy-eight older subjects (age: 57.55 ± 4.06 years, body mass: 72.26 ± 13.96 kg, body mass index: 26.73 ± 2.97 kg/m2) with CKD undergoing maintenance hemodialysis were randomly divided into control group (CG, n = 26), traditional RT (RT, n = 26) and cluster-set RT (RT-CS, n = 26) groups. Subjects completed 24 weeks of RT three times per week, 1 h and 30 min before the hemodialysis session, and each training lasted around 60 to 80 min. There was a group×time interaction for total BMD, femur BMD, L3-L4 BMD, and femoral neck BMD, revealed by improvements for RT and RT-CS groups (pre versus post). Only femur BMD displayed differences as compared with the CG. Minimum clinically important difference (MCID) values revealed more responsive subjects in the RT-CS group for total BMD, femur BMD, klotho, FGF23, sclerostin, Vitamin D and calcium. In conclusion, RT can be used as a non-pharmacological complementary strategy for the treatment of CKD. RT-CS may be useful for these subjects as more responders were found for this type of training.

慢性肾脏病(CKD)与一系列矿物质骨骼紊乱有关,这是因为副肾激素分泌增加,从而提高了破骨细胞的活性,清除了骨骼中的钙和磷。然而,文献中缺乏对不同阻力训练(RT)方法(如集群训练)在这类人群中的可行性研究。因此,本研究旨在比较传统阻力训练方案和集群阻力训练方案对患有慢性肾脏病的老年受试者的骨矿物质密度(BMD)T 值、BMD 总值、股骨 BMD、L3-L4 BMD、股骨颈 BMD、Klotho、FGF23、Klotho - FGF23 比值、Sclerostin、维生素 D、磷和钙的影响。78 名老年受试者(年龄:57.55±4.06 岁,体重:72.26±13.96 千克,身体质量指数:26.73±2.97 千克)进行了研究:他们被随机分为对照组(CG,n = 26)、传统 RT 组(RT,n = 26)和集群 RT 组(RT-CS,n = 26)。受试者每周完成三次为期24周的RT训练,分别在血液透析前1小时和30分钟进行,每次训练持续约60至80分钟。总 BMD、股骨 BMD、L3-L4 BMD 和股骨颈 BMD 存在组与时间的交互作用,RT 组和 RT-CS 组(前与后)的改善情况表明了这一点。只有股骨 BMD 与 CG 相比存在差异。最小临床重要差异(MCID)值显示,RT-CS 组受试者对总 BMD、股骨 BMD、klotho、FGF23、硬骨素、维生素 D 和钙的反应更灵敏。总之,RT 可作为治疗慢性肾功能衰竭的非药物补充策略。RT-CS可能对这些受试者有用,因为在这种类型的训练中发现了更多的应答者。
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引用次数: 0
Investigating the link between gut microbiome and bone mineral density: The role of genetic factors 调查肠道微生物群与骨矿物质密度之间的联系:遗传因素的作用
IF 3.5 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-22 DOI: 10.1016/j.bone.2024.117239
Ningxin Gao , Yue Zhuang , Yi Zheng , Yucan Li , Yawen Wang , Sibo Zhu , Min Fan , Weizhong Tian , Yanfeng Jiang , Yingzhe Wang , Mei Cui , Chen Suo , Tiejun Zhang , Li Jin , Xingdong Chen , Kelin Xu

Osteoporosis is a complex metabolic bone disease that severely undermines the quality of life and overall health of the elderly. While previous studies have established a close relationship between gut microbiome and host bone metabolism, the role of genetic factors has received less scrutiny. This research aims to identify potential taxa associated with various bone mineral density states, incorporating assessments of genetic factors. Fecal microbiome profiles from 605 individuals (334 females and 271 males) aged 55–65 from the Taizhou Imaging Study with osteopenia (n = 270, 170 women) or osteoporosis (n = 94, 85 women) or normal (n = 241, 79 women) were determined using shotgun metagenomic sequencing. The linear discriminant analysis was employed to identify differentially enriched taxa. Utilizing the Kyoto Encyclopedia of Genes and Genomes for annotation, functional pathway analysis was conducted to identify differentially metabolic pathways. Polygenic risk score for osteoporosis was estimated to represent genetic susceptibility to osteoporosis, followed by stratification and interaction analyses. Gut flora diversity did not show significant differences among various bone mineral groups. After multivariable adjustment, certain species, such as Clostridium leptum, Fusicatenibacter saccharivorans and Roseburia hominis, were enriched in osteoporosis patients. Statistically significant interactions between the polygenic risk score and taxa Roseburia faecis, Megasphaera elsdenii were observed (P for interaction = 0.005, 0.018, respectively). Stratified analyses revealed a significantly negative association between Roseburia faecis and bone mineral density in the low-genetic-risk group (β = −0.045, P < 0.05), while Turicimonas muris was positively associated with bone mineral density in the high-genetic-risk group (β = 4.177, P < 0.05) after multivariable adjustments. Functional predictions of the gut microbiome indicated an increase in pathways related to structural proteins in high-genetic-risk patients, while low-genetic-risk patients exhibited enrichment in enzyme-related pathways. This study emphasizes the association between gut microbes and bone mass, offering new insights into the interaction between genetic background and gut microbiome.

骨质疏松症是一种复杂的代谢性骨病,严重影响老年人的生活质量和整体健康。虽然之前的研究已经确定了肠道微生物组与宿主骨代谢之间的密切关系,但遗传因素的作用却较少受到关注。本研究旨在确定与各种骨矿物质密度状态相关的潜在分类群,并结合对遗传因素的评估。本研究使用霰弹枪元基因组测序技术测定了台州影像研究中 605 名 55-65 岁骨质疏松(270 人,170 名女性)或骨质疏松症(94 人,85 名女性)或正常(241 人,79 名女性)患者(334 名女性和 271 名男性)的粪便微生物组图谱。采用线性判别分析来确定差异富集类群。利用《京都基因和基因组百科全书》(Kyoto Encyclopedia of Genes and Genomes)进行注释,并进行功能通路分析,以确定不同的代谢通路。通过估算骨质疏松症的多基因风险得分来代表骨质疏松症的遗传易感性,然后进行分层和交互分析。肠道菌群多样性在不同的骨矿物质组别中未显示出显著差异。经多变量调整后,骨质疏松症患者的某些菌群,如瘦肉梭状芽孢杆菌、Fusicatenibacter saccharivorans 和 Roseburia hominis,出现了富集。多基因风险评分与Roseburia faecis、Megasphaera elsdenii类群之间存在统计学意义上的交互作用(交互作用的P分别为0.005和0.018)。分层分析显示,在低遗传风险组中,Roseburia faecis 与骨矿物质密度之间存在明显的负相关(β = -0.045,P.
{"title":"Investigating the link between gut microbiome and bone mineral density: The role of genetic factors","authors":"Ningxin Gao ,&nbsp;Yue Zhuang ,&nbsp;Yi Zheng ,&nbsp;Yucan Li ,&nbsp;Yawen Wang ,&nbsp;Sibo Zhu ,&nbsp;Min Fan ,&nbsp;Weizhong Tian ,&nbsp;Yanfeng Jiang ,&nbsp;Yingzhe Wang ,&nbsp;Mei Cui ,&nbsp;Chen Suo ,&nbsp;Tiejun Zhang ,&nbsp;Li Jin ,&nbsp;Xingdong Chen ,&nbsp;Kelin Xu","doi":"10.1016/j.bone.2024.117239","DOIUrl":"10.1016/j.bone.2024.117239","url":null,"abstract":"<div><p>Osteoporosis is a complex metabolic bone disease that severely undermines the quality of life and overall health of the elderly. While previous studies have established a close relationship between gut microbiome and host bone metabolism, the role of genetic factors has received less scrutiny. This research aims to identify potential taxa associated with various bone mineral density states, incorporating assessments of genetic factors. Fecal microbiome profiles from 605 individuals (334 females and 271 males) aged 55–65 from the Taizhou Imaging Study with osteopenia (<em>n</em> = 270, 170 women) or osteoporosis (<em>n</em> = 94, 85 women) or normal (<em>n</em> = 241, 79 women) were determined using shotgun metagenomic sequencing. The linear discriminant analysis was employed to identify differentially enriched taxa. Utilizing the Kyoto Encyclopedia of Genes and Genomes for annotation, functional pathway analysis was conducted to identify differentially metabolic pathways. Polygenic risk score for osteoporosis was estimated to represent genetic susceptibility to osteoporosis, followed by stratification and interaction analyses. Gut flora diversity did not show significant differences among various bone mineral groups. After multivariable adjustment, certain species, such as <em>Clostridium leptum</em>, <em>Fusicatenibacter saccharivorans</em> and <em>Roseburia hominis,</em> were enriched in osteoporosis patients. Statistically significant interactions between the polygenic risk score and taxa <em>Roseburia faecis, Megasphaera elsdenii</em> were observed (<em>P</em> for interaction = 0.005, 0.018, respectively). Stratified analyses revealed a significantly negative association between <em>Roseburia faecis</em> and bone mineral density in the low-genetic-risk group (β = −0.045, <em>P</em> &lt; 0.05), while <em>Turicimonas muris</em> was positively associated with bone mineral density in the high-genetic-risk group (β = 4.177, <em>P</em> &lt; 0.05) after multivariable adjustments. Functional predictions of the gut microbiome indicated an increase in pathways related to structural proteins in high-genetic-risk patients, while low-genetic-risk patients exhibited enrichment in enzyme-related pathways. This study emphasizes the association between gut microbes and bone mass, offering new insights into the interaction between genetic background and gut microbiome.</p></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142047581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of COVID-19 public health restrictions on fall-related hip fracture hospitalizations: An interrupted time series analysis COVID-19 公共卫生限制对跌倒相关髋部骨折住院治疗的影响:间断时间序列分析。
IF 3.5 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-17 DOI: 10.1016/j.bone.2024.117237
Seigo Mitsutake , Reidar P. Lystad , Janet C. Long , Jeffrey Braithwaite , Rebecca Mitchell

Purpose

There is limited evidence regarding the impact of public health restrictions on hip fracture hospitalization by place of fracture occurrence. This study aimed to examine the impact of COVID-19 public health restrictions on fall-related hip fracture hospitalization rates by place of occurrence.

Methods

This retrospective cohort study was conducted using hospitalization data in New South Wales, Australia, between January 2014 and June 2022. Older adults aged ≥65 years admitted to hospital following a fall-related hip fracture. An interrupted time-series analysis using autoregressive integrated moving average models evaluated the impact of public health restrictions on fall-related hip fracture hospitalization by place of fracture occurrence (home/residence, residential aged care facility (RACF), or away from usual residence).

Results

The mean observed fall-related hip fracture hospitalization rate during COVID-19 public health restrictions (36.3 per 100,000 people per month) was 13.4 % lower than the forecasted rate (41.1 per 100,000 people per month). The mean observed hospitalization rates for fall-related hip fractures at home/residence, at a RACF, and away from the usual residence were 3.8 %, 18.5 %, and 40.1 % lower than the forecasted rates, respectively. Level changes in the fall-related hip fracture hospitalization rates at RACFs and away from usual residences were −0.9 per 100,000 people per month (95 % CI −1.6 to −0.2) and −1.7 per 100,000 people per month (95 % CI −2.5 to −0.9), respectively.

Conclusions

There was a decline in fall-related hip fracture hospitalization rates among older adults, where the fracture occurred at RACFs and away from a person's usual residence during COVID-19 public health restrictions.

目的:关于公共卫生限制对骨折发生地髋部骨折住院率的影响,目前证据有限。本研究旨在探讨 COVID-19 公共卫生限制措施对不同发生地与跌倒相关的髋部骨折住院率的影响:这项回顾性队列研究使用了 2014 年 1 月至 2022 年 6 月期间澳大利亚新南威尔士州的住院数据。年龄≥65 岁的老年人因跌倒相关髋部骨折住院。利用自回归综合移动平均模型进行间断时间序列分析,评估了公共卫生限制措施对跌倒相关髋部骨折住院治疗的影响,并按骨折发生地(家中/住所、养老院(RACF)或远离常住地)进行了分类:在 COVID-19 公共卫生限制期间,平均观察到的跌倒相关髋部骨折住院率(每 10 万人每月 36.3 例)比预测住院率(每 10 万人每月 41.1 例)低 13.4%。与跌倒相关的髋部骨折在家中/住所、区域医疗中心和远离常住地的平均观察住院率分别比预测住院率低 3.8%、18.5% 和 40.1%。在区域医疗中心和远离常住地的跌倒相关髋部骨折住院率的水平变化分别为每月每10万人中-0.9(95 % CI -1.6 至 -0.2)和每月每10万人中-1.7(95 % CI -2.5至 -0.9):结论:在 COVID-19 公共卫生限制期间,老年人因摔倒导致的髋部骨折住院率有所下降,骨折发生在 RACF 和远离常住地的地方。
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引用次数: 0
The role of bone in energy metabolism: A focus on osteocalcin 骨骼在能量代谢中的作用:关注骨钙素。
IF 3.5 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-08-15 DOI: 10.1016/j.bone.2024.117238
Cassandra Smith , Xuzhu Lin , Lewan Parker , Bu B. Yeap , Alan Hayes , Itamar Levinger

Understanding the mechanisms involved in whole body glucose regulation is key for the discovery of new treatments for type 2 diabetes (T2D). Historically, glucose regulation was largely focused on responses to insulin and glucagon. Impacts of incretin-based therapies, and importance of muscle mass, are also highly relevant. Recently, bone was recognized as an endocrine organ, with several bone proteins, known as osteokines, implicated in glucose metabolism through their effects on the liver, skeletal muscle, and adipose tissue. Research efforts mostly focused on osteocalcin (OC) as a leading example. This review will provide an overview on this role of bone by discussing bone turnover markers (BTMs), the receptor activator of nuclear factor kB ligand (RANKL), osteoprotegerin (OPG), sclerostin (SCL) and lipocalin 2 (LCN2), with a focus on OC. Since 2007, some, but not all, research using mostly OC genetically modified animal models suggested undercarboxylated (uc) OC acts as a hormone involved in energy metabolism. Most data generated from in vivo, ex vivo and in vitro models, indicate that exogenous ucOC administration improves whole-body and skeletal muscle glucose metabolism. Although data in humans are generally supportive, findings are often discordant likely due to methodological differences and observational nature of that research. Overall, evidence supports the concept that bone-derived factors are involved in energy metabolism, some having beneficial effects (ucOC, OPG) others negative (RANKL, SCL), with the role of some (LCN2, other BTMs) remaining unclear. Whether the effect of osteokines on glucose regulation is clinically significant and of therapeutic value for people with insulin resistance and T2D remains to be confirmed.

了解全身葡萄糖调节机制是发现 2 型糖尿病(T2D)新疗法的关键。一直以来,葡萄糖调节主要集中在对胰岛素和胰高血糖素的反应上。基于增量素的疗法的影响以及肌肉质量的重要性也与此密切相关。最近,骨骼被认为是一个内分泌器官,有几种骨蛋白(称为骨激肽)通过对肝脏、骨骼肌和脂肪组织的影响与葡萄糖代谢有关。研究工作主要集中在骨钙素(OC)上。本综述将通过讨论骨转换标志物(BTMs)、核因子 kB 配体受体激活剂(RANKL)、骨保护gerin(OPG)、硬骨素(SCL)和脂钙蛋白 2(LCN2),对骨的这种作用进行概述,并重点讨论骨钙素。自 2007 年以来,一些(但并非所有)研究发现,主要使用 OC 转基因动物模型的研究表明,羧化不足(uc)的 OC 是一种参与能量代谢的激素。从体内、体外和体外模型中获得的大多数数据表明,外源性ucOC 能改善全身和骨骼肌的葡萄糖代谢。虽然人体数据总体上是支持性的,但可能由于研究方法的差异和观察性质,研究结果往往不一致。总体而言,有证据支持骨源性因子参与能量代谢的概念,其中一些因子具有有益作用(ucOC、OPG),另一些则具有负面作用(RANKL、SCL),还有一些因子(LCN2、其他 BTMs)的作用尚不明确。骨激酶对葡萄糖调节的影响是否具有临床意义,对胰岛素抵抗和 T2D 患者是否具有治疗价值,仍有待证实。
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引用次数: 0
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