Background: Preterm birth（PTB） is a primary cause of neonatal morbidity and mortality, the pathogenic mechanisms of PTB still remain largely unexplored. In the present study, we aimed to identify potential key genes and pathway associated with PTB by bioinformatics analysis. Methods: The GSE46510 dataset was obtained from GEO database. Differentially expressed genes (DEGs) were identified using the limma package in R software, the functional enrichment analysis was performed, and the protein-protein interaction (PPI) network was constructed by Cytoscape software. The network topology was analyzed using MCODE. Results: A total of 335 DEGs were identified from the dataset. The majority of up-regulated DEGs were significantly enriched in inflammatory response, while down-regulated DEGs were mainly enriched in mitotic nuclear division. The top 5 hub up regulated genes were ITGAM, IL1B, ITGAX, NFKB1, and SOCS3. Pathway analysis indicated enrichment in Cytokine-cytokine receptor interaction, signaling by Interleukins. The top 5 hub down regulated genes were CXCR4, ANAPC10, ANAPC4, UBE2V2, UBA3, Pathway analysis indicated enrichment in Ubiquitin mediated proteolysis, Phosphorylation of the APC/C. Conclusion: Our study indicated genes and pathways in PTB by bioinformatics analysis, which may provide novel insights for unraveling pathogenesis of PTB.
{"title":"Identification of Key Candidate Genes and Pathways in Preterm Birth by Integrated Bioinformatical Analysis","authors":"Aihua Chen","doi":"10.31579/2642-9756/046","DOIUrl":"https://doi.org/10.31579/2642-9756/046","url":null,"abstract":"Background: Preterm birth（PTB） is a primary cause of neonatal morbidity and mortality, the pathogenic mechanisms of PTB still remain largely unexplored. In the present study, we aimed to identify potential key genes and pathway associated with PTB by bioinformatics analysis. Methods: The GSE46510 dataset was obtained from GEO database. Differentially expressed genes (DEGs) were identified using the limma package in R software, the functional enrichment analysis was performed, and the protein-protein interaction (PPI) network was constructed by Cytoscape software. The network topology was analyzed using MCODE. Results: A total of 335 DEGs were identified from the dataset. The majority of up-regulated DEGs were significantly enriched in inflammatory response, while down-regulated DEGs were mainly enriched in mitotic nuclear division. The top 5 hub up regulated genes were ITGAM, IL1B, ITGAX, NFKB1, and SOCS3. Pathway analysis indicated enrichment in Cytokine-cytokine receptor interaction, signaling by Interleukins. The top 5 hub down regulated genes were CXCR4, ANAPC10, ANAPC4, UBE2V2, UBA3, Pathway analysis indicated enrichment in Ubiquitin mediated proteolysis, Phosphorylation of the APC/C. Conclusion: Our study indicated genes and pathways in PTB by bioinformatics analysis, which may provide novel insights for unraveling pathogenesis of PTB.","PeriodicalId":93058,"journal":{"name":"Women health care and issues","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45454294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-01Epub Date: 2021-05-12DOI: 10.31579/2642-9756/058
Pascal J Goldschmidt-Clermont, Alexander J P Goldschmidt, Roy E Weiss
For the first time in human history, obtaining a COVID-19 vaccine has become essential for the sustainability of our species. As an amazing product of collective ideation, remarkably safe and efficient vaccines have been invented, tested, distributed, and administered to the population on a voluntary basis. The fast-mutating individual behavior of the virus is probably guided by a similar goal of the sustainability of the species. With this commentary, we analyze and compare two means of sustainability through adaptability: collective ideation in the case of humans and individual mutations in the case of viruses - two very different species whose behaviors are driven by sustainability.
{"title":"Rivalry between human ideation and virus mutation: two competing means of sustainability.","authors":"Pascal J Goldschmidt-Clermont, Alexander J P Goldschmidt, Roy E Weiss","doi":"10.31579/2642-9756/058","DOIUrl":"https://doi.org/10.31579/2642-9756/058","url":null,"abstract":"<p><p>For the first time in human history, obtaining a COVID-19 vaccine has become essential for the sustainability of our species. As an amazing product of collective ideation, remarkably safe and efficient vaccines have been invented, tested, distributed, and administered to the population on a voluntary basis. The fast-mutating individual behavior of the virus is probably guided by a similar goal of the sustainability of the species. With this commentary, we analyze and compare two means of sustainability through adaptability: collective ideation in the case of humans and individual mutations in the case of viruses - two very different species whose behaviors are driven by sustainability.</p>","PeriodicalId":93058,"journal":{"name":"Women health care and issues","volume":"4 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439168/pdf/nihms-1735679.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39423188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Hysterectomy is world wide's second most commonly done gynecological surgery, second only to the caesarean section. There is no general consensus, however, about the optimal hysterectomy process. Hysterectomy may be achieved through different techniques such as stomach, vaginal and laparoscopic. The goal of the study is to explore whether the hysterectomy of minilaparotomy for benign uterine lesions may be a viable option to laparoscopic hysterectomy in terms of short-term operational and postoperative performance. Methods: 105 patients who were due to undergo complete hysterectomy for a benign uterine lesion were split into 3 categories according to their preference of therapeutic therapy method: group A (35 patients) minilaparotomy hysterectomy utilizing traditional sutures. Group B (35 patients) minilaparotomy hysterectomy utilizing bipolar vessel sealing procedure (Ligasure). Group C (35patients) laparoscopic hysterectomy using Ligasure. Result (s): The operating time in Group A (84.71 ± 9.91 minutes), group B (55.31 ± 7.81 minutes), while group C (94.81 ± 16.1 minutes).The duration until resumption of intestinal sounds in group C (12.31 ± 2.51 hours) in comparison to group A (17.41 ± 1.91 hours) and group B (16.51 ± 1.761 hours). Blood loss in group B (99.11 ± 30.81 ml), group A (130.31 ± 54.41 ml) and group C (136.61 ± 6.61 ml). The longest hospital stay occurred in group A (31.8 1± 5.71 hours) versus groups B (20.71 ± 2.51 hours) and C (19.31 ± 6.1 hours). The highest pain score was observed in group A (5.21 ± 1.11) versus groups B (3.81 ± 1.61) and C (3.71 ± 1.21). There was no significant difference in the incidence of intraoperative or postoperative complications. Conclusion (s): Less operational time and intraoperative blood loss were correlated with the usage of ligasure bipolar vessel sealing device in minilaparotomy hysterectomy, whereas it was comparable to laparoscopic hysterectomy in hospital stay and low morbidity postoperative pain scoring and a limited hospital stay. It can be an acceptable alternative to laparoscopic hysterectomy, suitable in areas without laparoscopic experience or facilities.
{"title":"Minilaparotomy hysterectomy Versus laparoscopic hysterectomy for benign uterine lesions A Comparative study","authors":"Ayman A. El-Dorf","doi":"10.31579/2642-9756/037","DOIUrl":"https://doi.org/10.31579/2642-9756/037","url":null,"abstract":"Background: Hysterectomy is world wide's second most commonly done gynecological surgery, second only to the caesarean section. There is no general consensus, however, about the optimal hysterectomy process. Hysterectomy may be achieved through different techniques such as stomach, vaginal and laparoscopic. The goal of the study is to explore whether the hysterectomy of minilaparotomy for benign uterine lesions may be a viable option to laparoscopic hysterectomy in terms of short-term operational and postoperative performance. Methods: 105 patients who were due to undergo complete hysterectomy for a benign uterine lesion were split into 3 categories according to their preference of therapeutic therapy method: group A (35 patients) minilaparotomy hysterectomy utilizing traditional sutures. Group B (35 patients) minilaparotomy hysterectomy utilizing bipolar vessel sealing procedure (Ligasure). Group C (35patients) laparoscopic hysterectomy using Ligasure. Result (s): The operating time in Group A (84.71 ± 9.91 minutes), group B (55.31 ± 7.81 minutes), while group C (94.81 ± 16.1 minutes).The duration until resumption of intestinal sounds in group C (12.31 ± 2.51 hours) in comparison to group A (17.41 ± 1.91 hours) and group B (16.51 ± 1.761 hours). Blood loss in group B (99.11 ± 30.81 ml), group A (130.31 ± 54.41 ml) and group C (136.61 ± 6.61 ml). The longest hospital stay occurred in group A (31.8 1± 5.71 hours) versus groups B (20.71 ± 2.51 hours) and C (19.31 ± 6.1 hours). The highest pain score was observed in group A (5.21 ± 1.11) versus groups B (3.81 ± 1.61) and C (3.71 ± 1.21). There was no significant difference in the incidence of intraoperative or postoperative complications. Conclusion (s): Less operational time and intraoperative blood loss were correlated with the usage of ligasure bipolar vessel sealing device in minilaparotomy hysterectomy, whereas it was comparable to laparoscopic hysterectomy in hospital stay and low morbidity postoperative pain scoring and a limited hospital stay. It can be an acceptable alternative to laparoscopic hysterectomy, suitable in areas without laparoscopic experience or facilities.","PeriodicalId":93058,"journal":{"name":"Women health care and issues","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42360056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Accurate estimation of gestational age is necessary to obtain materials for different tests as well as to interpret the results of these tests.Unfortunately sometimes calculation of EDD based on LMP becomes very difficult when (a) The menstrual cycle is irregular; (b) Patient fails to remember LMP or reports inaccurately (c) Pregnancy occurs during lactational amenorrhoea & (d) if patient have bleeding in early pregnancy. After 24 weeks the symphysio-fundal height in cm. approximates to the number of weeks up to 36 weeks of gestation. But a number of factors influence the measurement including multiple gestation, IUGR, diabetic pregnancy, maternal size, variation in fetal lie & engagement as well as inter & intra observer measurement variation.Ultrasonic measurement of fetal biometry (CRL, BPD, FL) are considered to be reliable when they are performed in first & early 2nd trimester (<24 weeks). In this study, we aimed to evaluate the accuracy of ultrasonographic fetal kidney length measurement as a new parameter for estimation of gestational age in late second and third trimester in correlation to other commenly used parameters as, BPD, FL, AC. This study was conducted on 122 pregnant women attending antenatal care clinics of Obstetrics and Gynecology department Soliman Fakeeh Hospital, KSA. All were in the late second and third trimester (between 24-40 weeks) of gestation. Cases included in the study were divided into four gestational age groups with four weeks interval. The length of the fetal kidney was measured. The mean gestational age was calculated on the bases of biparietal diameter (BPD).femur length (FL) and abdominal circumference (AC). The fetal kidney measurements were obtained by the same sonographer to avoid interobserver variation using (GE machine E8) and were compared with gestational age using statistical analysis No statistically significant differences were found between the right and the left renal measurements in cases in which the two kidneys were imaged In this study, during the second and third trimester the mean kidney length showed gradual rate of increase. the mean kidney length was found to be 30.52.1 mm at mean gestational age of 26weeks and became at the mean gestational age of34 weeks, 40.4103 mm(:(±1.98) and at mean gestational age of 38 week it measured44.41mm((±2.1). In addition, we found a positive correlation between kidney length and gestational age. We suggested regression Formula to calculate it. Conclusion: Throughout this study, we can conclude that Fetal kidney length could be used with accuracy in the late second and third trimester especially in women who are uncertain of date of LMP and are booked late for ANC.however its accuracy is decreased when we use it in late third trimester.Other ultrasonographic parameters used for estimation of the gestational age as BPD ,AC are less satisfactory ,when compared with femur length and kidney length.
{"title":"Evaluation of ultrasonographic fetal kidney length for gestational age detection in late second and third trimesters","authors":"Amal Zaghloul","doi":"10.31579/2642-9756/036","DOIUrl":"https://doi.org/10.31579/2642-9756/036","url":null,"abstract":"Accurate estimation of gestational age is necessary to obtain materials for different tests as well as to interpret the results of these tests.Unfortunately sometimes calculation of EDD based on LMP becomes very difficult when (a) The menstrual cycle is irregular; (b) Patient fails to remember LMP or reports inaccurately (c) Pregnancy occurs during lactational amenorrhoea & (d) if patient have bleeding in early pregnancy. After 24 weeks the symphysio-fundal height in cm. approximates to the number of weeks up to 36 weeks of gestation. But a number of factors influence the measurement including multiple gestation, IUGR, diabetic pregnancy, maternal size, variation in fetal lie & engagement as well as inter & intra observer measurement variation.Ultrasonic measurement of fetal biometry (CRL, BPD, FL) are considered to be reliable when they are performed in first & early 2nd trimester (<24 weeks). In this study, we aimed to evaluate the accuracy of ultrasonographic fetal kidney length measurement as a new parameter for estimation of gestational age in late second and third trimester in correlation to other commenly used parameters as, BPD, FL, AC. This study was conducted on 122 pregnant women attending antenatal care clinics of Obstetrics and Gynecology department Soliman Fakeeh Hospital, KSA. All were in the late second and third trimester (between 24-40 weeks) of gestation. Cases included in the study were divided into four gestational age groups with four weeks interval. The length of the fetal kidney was measured. The mean gestational age was calculated on the bases of biparietal diameter (BPD).femur length (FL) and abdominal circumference (AC). The fetal kidney measurements were obtained by the same sonographer to avoid interobserver variation using (GE machine E8) and were compared with gestational age using statistical analysis No statistically significant differences were found between the right and the left renal measurements in cases in which the two kidneys were imaged In this study, during the second and third trimester the mean kidney length showed gradual rate of increase. the mean kidney length was found to be 30.52.1 mm at mean gestational age of 26weeks and became at the mean gestational age of34 weeks, 40.4103 mm(:(±1.98) and at mean gestational age of 38 week it measured44.41mm((±2.1). In addition, we found a positive correlation between kidney length and gestational age. We suggested regression Formula to calculate it. Conclusion: Throughout this study, we can conclude that Fetal kidney length could be used with accuracy in the late second and third trimester especially in women who are uncertain of date of LMP and are booked late for ANC.however its accuracy is decreased when we use it in late third trimester.Other ultrasonographic parameters used for estimation of the gestational age as BPD ,AC are less satisfactory ,when compared with femur length and kidney length.","PeriodicalId":93058,"journal":{"name":"Women health care and issues","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42324626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Klotho was discovered in 1997 as an anti-aging gene that, when overexpressed, may extend the life span, but when it is disrupted, it may be a factor responsible for premature aging syndrome. The structure and the role of αKlotho and βKlotho genes from Klotho family in malignant tumors is described. The expression profile of the βKlotho gene is significantly different from the expression of the αKlotho gene. Analysis of Klotho expression in breast cancer, cervical cancer as well as endometrial cancer are discussed. The available data indicate the involvement of βKlotho in the neoplastic transformation of the endometrium. More advanced disease is related to negative expression of βKlotho gene. Fibroblast growth factors (FGFs) are a large family of proteins characterized by different functions in the cell development and metabolism. The FGF signaling is also associated with cancerogenesis. The relation between some FGF subfamilies and endometrial cancer clinical data is reported. The interaction between FGF subfamilies and the Klotho subfamily proteins acting as a co-receptor is stressed. Disorders in signaling of the FGF / FGFR pathway have been confirmed in gynecology. It can be assumed that increased expression of FGF21 might be a suppressor factor in endometrial cancer. The FGF21 factor, like the βKlotho protein, achieves its biological effect via the FGFR1 receptor. High expression of the FGFR1 gene inhibits further tumor growth. FGFR1 has the potential to perform both a suppressor and promoter role in the oncogenesis process.
{"title":"The Role of The ?klotho Gene, Fgf21 and Fgfr1 in Cancerogenesis","authors":"Wójcik-Krowiranda Katarzyna","doi":"10.31579/2642-9756/003","DOIUrl":"https://doi.org/10.31579/2642-9756/003","url":null,"abstract":"Klotho was discovered in 1997 as an anti-aging gene that, when overexpressed, may extend the life span, but when it is disrupted, it may be a factor responsible for premature aging syndrome. The structure and the role of αKlotho and βKlotho genes from Klotho family in malignant tumors is described. The expression profile of the βKlotho gene is significantly different from the expression of the αKlotho gene. Analysis of Klotho expression in breast cancer, cervical cancer as well as endometrial cancer are discussed. The available data indicate the involvement of βKlotho in the neoplastic transformation of the endometrium. More advanced disease is related to negative expression of βKlotho gene. Fibroblast growth factors (FGFs) are a large family of proteins characterized by different functions in the cell development and metabolism. The FGF signaling is also associated with cancerogenesis. The relation between some FGF subfamilies and endometrial cancer clinical data is reported. The interaction between FGF subfamilies and the Klotho subfamily proteins acting as a co-receptor is stressed. Disorders in signaling of the FGF / FGFR pathway have been confirmed in gynecology. It can be assumed that increased expression of FGF21 might be a suppressor factor in endometrial cancer. The FGF21 factor, like the βKlotho protein, achieves its biological effect via the FGFR1 receptor. High expression of the FGFR1 gene inhibits further tumor growth. FGFR1 has the potential to perform both a suppressor and promoter role in the oncogenesis process.","PeriodicalId":93058,"journal":{"name":"Women health care and issues","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42409466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"In Response to COVID-19: Frontline Experience in a Tertiary Obstetrics and Gynecology Hospital","authors":"Lily Kho Cl","doi":"10.31579/2642-9756/031","DOIUrl":"https://doi.org/10.31579/2642-9756/031","url":null,"abstract":"","PeriodicalId":93058,"journal":{"name":"Women health care and issues","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44156489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Employees to take anti-harassment training every year, meant to cover discrimination in it has many forms. It also encourages them to participate in training programs that support an employee’s feeling safe to bring their whole selves to work,’’ Check Blind Spots” series of immersive and interactive elements including virtual reality, gaming technology and more, to take an introspective look at the unconscious biases people face on a daily basis. Implicit bias training begins with the premise that have essentially benevolent in our intentions, but have all subject to maintaining conditioned prejudices, the acquisition of which is often beyond our control. Executive Summary Black has affinity. The best definition for black is the statistic one in six – a reminder that beyond a point, one cannot control or ever completely prepare for the future. Believes black fingers afflict those who have a sinful past, people cannot compensate for the sin against the unseen.
{"title":"How to attach Black over White co-worker dislike Burnside Pharmacy Institute in Pune University Specialized study","authors":"R. Hajare","doi":"10.31579/2642-9756/032","DOIUrl":"https://doi.org/10.31579/2642-9756/032","url":null,"abstract":"Employees to take anti-harassment training every year, meant to cover discrimination in it has many forms. It also encourages them to participate in training programs that support an employee’s feeling safe to bring their whole selves to work,’’ Check Blind Spots” series of immersive and interactive elements including virtual reality, gaming technology and more, to take an introspective look at the unconscious biases people face on a daily basis. Implicit bias training begins with the premise that have essentially benevolent in our intentions, but have all subject to maintaining conditioned prejudices, the acquisition of which is often beyond our control. Executive Summary Black has affinity. The best definition for black is the statistic one in six – a reminder that beyond a point, one cannot control or ever completely prepare for the future. Believes black fingers afflict those who have a sinful past, people cannot compensate for the sin against the unseen.","PeriodicalId":93058,"journal":{"name":"Women health care and issues","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49614313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aim of this work is evaluation of different management options for patients with morbidly adherent placenta and its effect on pregnancy outcomes to find the best method of management to decrease morbidity and mortality. In this prospective study, there were 42 patients diagnosed as having morbidly adherent placenta previa and hospitalized between January 2019 to February 2020. Different management options performed to patients with morbidly adherent placenta previa were recorded, blood loss was estimated for each patient, operative procedures, maternal and fetal outcome was recorded. The results showed the following: Different methods were tried to preserve the uterus including bilateral uterine artery ligation in 13 (59%) cases, bilateral ovarian artery ligation in 3 (13.6%) cases, bilateral internal iliac artery ligation in 3 (13.6%) cases, intrauterine tamponade in 4 (18.1%) cases and hemostatic sutures in placental bed in 11(50%) cases, while B-lynch suture was not done, while procedures which were performed to control pelvic hemorrhage after hysterectomy included internal iliac artery ligation in 8 (27.5%) cases, pelvic packing in 5 (17.2%) cases and internal iliac balloon inflation to control hemorrhage in 1 (3.4%) case. The postoperative complications were DIC occurred in 2 patients (4.8%), ICU admission occurred in 5 cases (11.9%), two cases required reoperations, one patient (2.4%) had wound infection, Postpartum collapse occurred in 2 case (4.8%). Pulmonary embolism occurred in 1 case (2.4%), Median duration of hospital stay was 4 days (range: 2-25).
{"title":"Assessment of different management options used in morbidly adherent placenta and pregnancy outcomes","authors":"W. Tawfik","doi":"10.31579/2642-9756/026","DOIUrl":"https://doi.org/10.31579/2642-9756/026","url":null,"abstract":"The aim of this work is evaluation of different management options for patients with morbidly adherent placenta and its effect on pregnancy outcomes to find the best method of management to decrease morbidity and mortality. In this prospective study, there were 42 patients diagnosed as having morbidly adherent placenta previa and hospitalized between January 2019 to February 2020. Different management options performed to patients with morbidly adherent placenta previa were recorded, blood loss was estimated for each patient, operative procedures, maternal and fetal outcome was recorded. The results showed the following: Different methods were tried to preserve the uterus including bilateral uterine artery ligation in 13 (59%) cases, bilateral ovarian artery ligation in 3 (13.6%) cases, bilateral internal iliac artery ligation in 3 (13.6%) cases, intrauterine tamponade in 4 (18.1%) cases and hemostatic sutures in placental bed in 11(50%) cases, while B-lynch suture was not done, while procedures which were performed to control pelvic hemorrhage after hysterectomy included internal iliac artery ligation in 8 (27.5%) cases, pelvic packing in 5 (17.2%) cases and internal iliac balloon inflation to control hemorrhage in 1 (3.4%) case. The postoperative complications were DIC occurred in 2 patients (4.8%), ICU admission occurred in 5 cases (11.9%), two cases required reoperations, one patient (2.4%) had wound infection, Postpartum collapse occurred in 2 case (4.8%). Pulmonary embolism occurred in 1 case (2.4%), Median duration of hospital stay was 4 days (range: 2-25).","PeriodicalId":93058,"journal":{"name":"Women health care and issues","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48693282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ziemlé Clément Méda, Der Adolphe Somé, H. Hien, Issiaka Kouanda, L. Hien
Intoduction This research assessed the determinants of the health services limited the supply of care related to the second pillar of the prevention of mother-child transmission of HIV (PMTCT) involving workers from the maternity units and the HIV active queues in the district hospitals and the Department of gynaecology, obstetrics and reproductive medicine (DGORM) of the National teaching hospital Souro Sanou (NTHSS) in the Region of Hauts Bassinsin the Region of Hauts Bassins, Burkina Faso. Materials and methods This was a cross-sectional study conducted from January 15 January to 30 July 2017. The study method used individual interview and the literature review (content analysis of national documents and activity reports on PMTCT). Results The main results included insufficient organization of services and low levels of the workers knowledge and activities related to the second pillar of PMTCT in the all health districts concerned. The second pillar of PMTCT has not been mentioned in any structure supervised. The definition of dual/double protection was only known by 9 (9.4%) participants. The knowledge of the strategies about the double protection was limited to a single strategy. The knowledge and activities on medically assisted procreation among people living with HIV were amost nil. The knowledge and practices on FP appropriate for People living wih HIV were poor. Conclusion For a successful PMTCT, it is important to implement its all four (04) pillars, taking into account the double/dual protection and the medically-assisted procreation.
{"title":"Determinants of the Health Services Limited the Supply of Care Related to the Second Pillar of the Prevention of Mother-Child Transmission of HIV in the Region of Hauts Bassins, Burkina Faso","authors":"Ziemlé Clément Méda, Der Adolphe Somé, H. Hien, Issiaka Kouanda, L. Hien","doi":"10.31579/2642-9756/019","DOIUrl":"https://doi.org/10.31579/2642-9756/019","url":null,"abstract":"Intoduction This research assessed the determinants of the health services limited the supply of care related to the second pillar of the prevention of mother-child transmission of HIV (PMTCT) involving workers from the maternity units and the HIV active queues in the district hospitals and the Department of gynaecology, obstetrics and reproductive medicine (DGORM) of the National teaching hospital Souro Sanou (NTHSS) in the Region of Hauts Bassinsin the Region of Hauts Bassins, Burkina Faso. Materials and methods This was a cross-sectional study conducted from January 15 January to 30 July 2017. The study method used individual interview and the literature review (content analysis of national documents and activity reports on PMTCT). Results The main results included insufficient organization of services and low levels of the workers knowledge and activities related to the second pillar of PMTCT in the all health districts concerned. The second pillar of PMTCT has not been mentioned in any structure supervised. The definition of dual/double protection was only known by 9 (9.4%) participants. The knowledge of the strategies about the double protection was limited to a single strategy. The knowledge and activities on medically assisted procreation among people living with HIV were amost nil. The knowledge and practices on FP appropriate for People living wih HIV were poor. Conclusion For a successful PMTCT, it is important to implement its all four (04) pillars, taking into account the double/dual protection and the medically-assisted procreation.","PeriodicalId":93058,"journal":{"name":"Women health care and issues","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47912414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dalia Mohammed Mohammed El-Khaldy, Mohamed Saeed Khallaf, Ahmed Mohamed Nour Eldin Hashad, Ibrahim Shazly Mohamed Amen Elshazly
Back ground: World Health Organization (WHO) defines infertility as a disease of the reproductive system defined by the failure to achieve a clinical pregnancy after 12 months or more of regular unprotected sexual intercourse. Worldwide, 8 to 12 percent of couples experience fertility problems. Causes of infertility in women were as follows: menstrual disorders (disorders of cycle length and flow) 62.6%, diseases (obesity, thyroid diseases, diabetes) 58.7%, impaired ovulation (hormonal disorders, oligoovulation and anovulation) 50.3%, uterine causes 16.7%, tubal factor 15.4%, and cervical causes 7.9%. In the male factor fertility there was semen abnormalities (44.6%), genetic factors (29.8%), anti-spermatogenesis agents (11%), and vascular disorders (17.2%). Aim of the Study: The purpose of this study is to evaluate the effect of sildenafil in endometrial ripening with induction of ovulation by clomiphene citrate in polycystic ovarian syndrome. Patients and methods: It is a randomized controlled trial on 65 infertile women with polycystic ovarian syndrome; patients were randomly divided into two equal groups. In control group, 31 patients were given oral sildenafil, one tablet every 12 hrs. From 2nd day of the cycle till 12th day and clomiphene citrate, one tablet every 12 hours, for 5 days from 3rd day of the menstrual cycle. In study group, 34 patients were given oral placebo, one tablet every 12 hrs. From 2nd day of the cycle till 12th day and clomiphene citrate, one tablet every 12 hours, for 5 days from 3rd day of the menstrual cycle. A transvaginal ultrasound was performed to evaluated the endometrial thickness before and after treatment, the follicularometeric was measured on day 11 and day13. Uterine artery Doppler was then measured. Qualitative serum B-hCG level was checked 14 days after ovulation to assess clinical pregnancy rate. Design: Prospective, Double blinded randomized controlled trial. Setting: Obstetrics & Gynecology outpatient clinic, Ain Shams University Hospital. Study duration: 3 months. Results: The present study was a double-blind, randomized, controlled study that was conducted on 65 women with PCOS who underwent induction of ovulation by Clomiphene citrate in outpatient clinic of Ain Shams University hospital. Conclusion: Our systematic review and meta-analysis showed that follicular supplementation of sildenafil citrate (oral or vaginal), alone or adjuvant therapy can be used for improving the EM and clinical pregnancy rate in women undergoing assisted reproduction. However, given the methodological limitations the current evidence does not support its use in clinical practice yet. Future high-quality RCT with large sample size to evaluate the sildenafil citrate effect in women undergoing assisted reproduction are needed. Future RCTs should focus on type of processing, stage of embryo, embryo quality, dosage, time of administration, type of control group, in order to identify the groups of patients who would benefit t
背景:世界卫生组织(世卫组织)将不孕症定义为一种生殖系统疾病，其特征是定期无保护性交12个月或更长时间后仍未实现临床妊娠。在世界范围内，8%到12%的夫妇都有生育问题。妇女不孕的原因如下:月经紊乱(周期长度和流量紊乱)62.6%，疾病(肥胖、甲状腺疾病、糖尿病)58.7%，排卵障碍(激素紊乱、排卵少和无排卵)50.3%，子宫原因16.7%，输卵管因素15.4%，宫颈原因7.9%。在男性因素生育中，精液异常(44.6%)、遗传因素(29.8%)、抗生精剂(11%)和血管疾病(17.2%)。研究目的:本研究的目的是评价西地那非对多囊卵巢综合征患者子宫内膜成熟和枸橼酸克罗米芬诱导排卵的影响。患者和方法:对65例多囊卵巢综合征不孕妇女进行随机对照试验;患者被随机分为两组。对照组31例患者口服西地那非，每12 h 1片。从月经周期第2天起至第12天，服用枸橼酸克罗米芬，每12小时一片，从月经周期第3天起连续服用5天。研究组34例患者口服安慰剂，每12小时1片。从月经周期第2天起至第12天，服用枸橼酸克罗米芬，每12小时一片，从月经周期第3天起连续服用5天。治疗前后行阴道超声检查子宫内膜厚度，第11天、第13天测量卵泡计。然后测量子宫动脉多普勒。排卵后14天检测定性血清B-hCG水平，评价临床妊娠率。设计:前瞻性、双盲随机对照试验。单位:艾因沙姆斯大学附属医院妇产科门诊。学习时间:3个月。结果:本研究是一项双盲、随机、对照研究，在艾因沙姆斯大学医院门诊接受枸橼酸克罗米芬诱导排卵的PCOS女性65例。结论:我们的系统回顾和荟萃分析显示，卵泡补充枸橼酸西地那非(口服或阴道)、单独或辅助治疗可提高辅助生殖妇女的EM和临床妊娠率。然而，由于方法学的局限性，目前的证据尚不支持其在临床实践中的应用。未来需要高质量的大样样量的随机对照试验来评估枸橼酸西地那非对辅助生殖妇女的影响。未来的随机对照试验应关注处理方式、胚胎阶段、胚胎质量、剂量、给药时间、对照组类型，以确定从该干预中获益最多的患者群体，以及柠檬酸西地那非最合适的剂量、时间和类型，从而产生最积极的效果，减少可能的副作用。
{"title":"Effect of Sildenafil in Endometrial Ripening with Induction of Ovulation by Clomiphene Citrate in Polycystic Ovarian Syndrome; Double Blinded; Randomized Controlled Trial","authors":"Dalia Mohammed Mohammed El-Khaldy, Mohamed Saeed Khallaf, Ahmed Mohamed Nour Eldin Hashad, Ibrahim Shazly Mohamed Amen Elshazly","doi":"10.31579/2642-9756/077","DOIUrl":"https://doi.org/10.31579/2642-9756/077","url":null,"abstract":"Back ground: World Health Organization (WHO) defines infertility as a disease of the reproductive system defined by the failure to achieve a clinical pregnancy after 12 months or more of regular unprotected sexual intercourse. Worldwide, 8 to 12 percent of couples experience fertility problems. Causes of infertility in women were as follows: menstrual disorders (disorders of cycle length and flow) 62.6%, diseases (obesity, thyroid diseases, diabetes) 58.7%, impaired ovulation (hormonal disorders, oligoovulation and anovulation) 50.3%, uterine causes 16.7%, tubal factor 15.4%, and cervical causes 7.9%. In the male factor fertility there was semen abnormalities (44.6%), genetic factors (29.8%), anti-spermatogenesis agents (11%), and vascular disorders (17.2%). Aim of the Study: The purpose of this study is to evaluate the effect of sildenafil in endometrial ripening with induction of ovulation by clomiphene citrate in polycystic ovarian syndrome. Patients and methods: It is a randomized controlled trial on 65 infertile women with polycystic ovarian syndrome; patients were randomly divided into two equal groups. In control group, 31 patients were given oral sildenafil, one tablet every 12 hrs. From 2nd day of the cycle till 12th day and clomiphene citrate, one tablet every 12 hours, for 5 days from 3rd day of the menstrual cycle. In study group, 34 patients were given oral placebo, one tablet every 12 hrs. From 2nd day of the cycle till 12th day and clomiphene citrate, one tablet every 12 hours, for 5 days from 3rd day of the menstrual cycle. A transvaginal ultrasound was performed to evaluated the endometrial thickness before and after treatment, the follicularometeric was measured on day 11 and day13. Uterine artery Doppler was then measured. Qualitative serum B-hCG level was checked 14 days after ovulation to assess clinical pregnancy rate. Design: Prospective, Double blinded randomized controlled trial. Setting: Obstetrics & Gynecology outpatient clinic, Ain Shams University Hospital. Study duration: 3 months. Results: The present study was a double-blind, randomized, controlled study that was conducted on 65 women with PCOS who underwent induction of ovulation by Clomiphene citrate in outpatient clinic of Ain Shams University hospital. Conclusion: Our systematic review and meta-analysis showed that follicular supplementation of sildenafil citrate (oral or vaginal), alone or adjuvant therapy can be used for improving the EM and clinical pregnancy rate in women undergoing assisted reproduction. However, given the methodological limitations the current evidence does not support its use in clinical practice yet. Future high-quality RCT with large sample size to evaluate the sildenafil citrate effect in women undergoing assisted reproduction are needed. Future RCTs should focus on type of processing, stage of embryo, embryo quality, dosage, time of administration, type of control group, in order to identify the groups of patients who would benefit t","PeriodicalId":93058,"journal":{"name":"Women health care and issues","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45076422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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