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Ubiquitous Usage of Over the Counter Medications in Pregnancy: Perspectives of Maternal Apprehensiveness 孕期普遍使用非处方药物:母亲忧虑的视角
Pub Date : 2022-01-06 DOI: 10.31579/2642-9756/097
Gudisa Bereda
The World Health Organization delineates self-medication as the utilization of medications by individuals in search of treating symptoms or self-diagnosed health state. During pregnancy, drug utilization is complicated because of incomplete data as clinical trials frequently don't enclose pregnant women, with reference to benefits and implicit undesirable outcomes on both the mother and the foetus. Bestowed limited data on the variety of over the counter medications applicable, physi­cians seek to counsel pregnant women about implicit pitfalls, and it is beneficial to give information on entire over the counter medications the patient is receiving at the preconception visit and entire distinctive ordinary visits. Antacid that containing sodium bicarbonate can cause fluid buildup in the tissues if used during pregnancy redundantly. Hypericum perforatum is ordinarily not recommended in preg­nancy because of a dearth of human data and it perhaps antecedent miscarriage and it also escalates the birth deformities of fetus. Early aspirinusage at the time of conception or in the 1st several weeks of pregnancy does not escalate the pitfall of spontaneous abortion.
世界卫生组织将自我用药定义为个人为了治疗症状或自我诊断的健康状态而使用药物。在怀孕期间,由于数据不完整,药物使用很复杂,因为临床试验通常没有涉及孕妇,涉及对母亲和胎儿的益处和潜在的不良结果。由于适用的各种非处方药的数据有限,医生们试图就隐性陷阱向孕妇提供建议,并且提供患者在预诊和完全不同的普通就诊中接受的全部非处方药信息是有益的。如果在怀孕期间过量使用含有碳酸氢钠的抗酸剂,会导致组织中的液体积聚。由于缺乏人类数据,通常不建议在怀孕期间使用贯叶金丝桃,而且它可能是流产的先兆,还会加剧胎儿的出生畸形。在怀孕时或怀孕前几周早期使用阿司匹林不会增加自然流产的风险。
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引用次数: 0
Twins Cosmas and Damian – Patron Saints of Doctors 双胞胎Cosmas和Damian——医生的守护神
Pub Date : 2022-01-06 DOI: 10.31579/2642-9756/095
W. Malinowski
Saint Luke is the one commonly believed to be a patron saint of physicians. The less known are Cosmas and Damian, the only twin physicians to have been declared saints in the Catholic Church. In Poland, we have been recently observing a growing interest in these saint twins. This is mainly associated with a return to the tradition of the Apothecary Feast, celebrated on September 26, the day of Cosmas’ and Damian’s martyr death.
圣卢克通常被认为是医生的守护神。不太为人所知的是Cosmas和Damian,他们是天主教会中唯一被宣布为圣徒的双胞胎医生。在波兰,我们最近观察到人们对这对圣双胞胎越来越感兴趣。这主要与回归药剂师盛宴的传统有关,药剂师盛宴于9月26日庆祝,这一天是科斯玛斯和达米安殉道的日子。
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引用次数: 0
Rivalry between Humans and Coronaviruses: Unanticipated Impact of Omicron. 人类与冠状病毒之间的竞争:奥密克戎的意外影响
Pub Date : 2022-01-01 Epub Date: 2022-03-08 DOI: 10.31579/2642-9756/109
Pascal J Goldschmidt-Clermont, Alexander J P Goldschmidt

With our prior Commentary we discussed the rivalry between ideation (humans) and mutations (viruses), (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439168/), and more specifically, we described and compared two means of adaptability: collective and focused ideation for humans and self-serving mutation for viruses. The amazingly fast development of new effective and safe vaccines and drugs requires the humankind's most sophisticated form of ideation ability to respond to threatening stressors such as a dangerous virus like SARS-CoV-2. The essence of what makes us human is that human ideation requires a society of people working towards the same goal and is interdependent on socialization for the sustainability of humankind. In contrast, viruses mutate alone and "selfishly". The best fit virus for a particular environment, for a particular host, eliminates the competition through successive mutations. The Omicron variant of concern (VoC) is a great example for how higher transmissibility and perhaps, stochasticity, can drive the transmissive success of a virus across an entire host species like humans. With this review, we describe how Omicron has impacted the COVID-19 pandemic in an unanticipated way that could bring an end to it.

在我们之前的评论中,我们讨论了意念(人类)和突变(病毒)之间的竞争(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439168/),更具体地说,我们描述并比较了两种适应性手段:人类的集体和集中思维和病毒的自我服务突变。新的有效和安全的疫苗和药物的惊人快速发展需要人类最复杂的思维能力来应对威胁性压力源,如严重急性呼吸系统综合征冠状病毒2型等危险病毒。使我们成为人的本质是,人类的思维需要一个由朝着同一目标努力的人组成的社会,并且为了人类的可持续性而与社会化相互依存。相比之下,病毒会独自“自私”地变异。最适合特定环境、特定宿主的病毒通过连续突变消除竞争。令人担忧的奥密克戎变异株(VoC)是一个很好的例子,说明更高的传播性,也许是随机性,可以推动病毒在整个宿主物种(如人类)中的传播成功。通过这篇综述,我们描述了奥密克戎如何以一种意想不到的方式影响新冠肺炎大流行,从而结束它。
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引用次数: 0
Perinatal Effects of Metformin use in Gestational Diabetes 二甲双胍治疗妊娠期糖尿病的围产期效果
Pub Date : 2021-12-13 DOI: 10.31579/2642-9756/094
Karen Mireya Topa Pila, Carlos Acosta Reyes, Miguel Arturo Llanos Guzmán, Helvey Ramón Zetién Arteaga, Lizeth Yurany Gómez Flórez, Daniel Jesús Villanueva Navarro, Paula Andrea Navarro Guerrero, Katia García Pertuz
Background: GD is a condition in which a woman develops glucose intolerance at any time during pregnancy and may or may not resolve at the end of pregnancy. Metformin, from the group of biguanides, is considered an alternative management of gestational diabetes, included in the list of essential medicines by the OMS. Methodology: A narrative review was carried out through various databases from March 2018 to September 2021; the search and selection of articles was carried out in journals indexed in English and Spanish. The following keywords were used: metformin, macrosomia, gestational diabetes. Results: The present review offers pathophysiological measures, complications, pharmacological therapy, for a better approach in perinatals in patients with gestational diabetes. Conclusion: With the results observed, it should be noted that metformin is viable for the management of patients with gestational diabetes.
背景:GD是一种妇女在怀孕期间任何时候都会出现葡萄糖不耐受的情况,在怀孕结束时可能会也可能不会消退。二甲双胍,来自双胍类,被认为是妊娠期糖尿病的一种替代治疗方法,被OMS列入基本药物清单。方法:从2018年3月到2021年9月,通过各种数据库进行了叙述性审查;文章的检索和选择是在以英语和西班牙语编制索引的期刊上进行的。使用了以下关键词:二甲双胍、巨大儿、妊娠期糖尿病。结果:本综述为妊娠期糖尿病患者的围产期治疗提供了病理生理学措施、并发症和药物治疗。结论:根据观察结果,应注意二甲双胍对妊娠期糖尿病患者的治疗是可行的。
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引用次数: 0
How Can We Treat Endometrial Polyp Without Using Curettage? 如何在不使用刮除术的情况下治疗子宫内膜息肉?
Pub Date : 2021-12-13 DOI: 10.31579/2642-9756/099
H. W. L.
Introduction: Endometrial polyps are considered begin tumours that protrude inside the uterine cavity. It affects women in reproductive or in menopausal age. It can regress spontaneously or if symptomatic, it can be treated efficiently by hysteroscopy excision. Purpose: to demonstrate that endometrium polyps can be treated without using curettage but only using homeopathic medication without needing to do any invasive procedure. Methods: through two case report (47 and 57 years-old women respectively, with endometrium polyps diagnosed by routine ultrasound). Both patients were programed to do hysteroscopy. They were doing acupuncture (for treatment of low back pain and pain in the shoulder respectively) using needles and mustard seeds. I decided to prescribe for both patients a homeopathy medication called Medorrhinum to treat their miasma. In both cases, they intake the medication first with 30CHXX-20 ml. After one month, the patients need to have the second round of this medication, now with 200CHXX-20 ml. After one month from the first medication, it was possible to intake the third medication, now in 1000CHXX-20 ml. Results: the endometrial polyps disappeared completely after the intake of these medications in both patients without needing to use hysteroscopy exam. Conclusion: the use of homeopathy medication called Medorrinun was very important to recover from the endometrium polyp without the necessity in using hysteroscopy exam and do the curettage.
引言:子宫内膜息肉被认为是子宫腔内突出的起始肿瘤。它影响育龄或更年期妇女。它可以自发消退,或者如果有症状,可以通过宫腔镜切除有效治疗。目的:证明子宫内膜息肉可以在不使用刮宫术的情况下进行治疗,而只需使用顺势疗法药物,无需进行任何侵入性手术。方法:通过两例病例报告(分别为47岁和57岁女性,常规超声诊断为子宫内膜息肉)。两名患者都接受了宫腔镜检查。他们用针和芥末籽进行针灸(分别治疗腰痛和肩部疼痛)。我决定给两位患者开一种名为Medorrinum的顺势疗法药物来治疗他们的mia。在这两种情况下,患者首先服用30CHXX-20 ml的药物。一个月后,患者需要进行第二轮药物治疗,现在为200CHXX-20 ml.在第一次药物治疗一个月之后,可以服用第三次药物,现在为1000CHXX-20毫升。结果:两例患者在服用这些药物后,子宫内膜息肉完全消失,无需进行宫腔镜检查。结论:使用名为Medorrinun的顺势疗法药物对子宫内膜息肉的恢复非常重要,无需使用宫腔镜检查和刮除。
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引用次数: 0
Placenta Accreta Syndrome- A Calamitous Diagnosis 胎盘增生综合征-灾难性的诊断
Pub Date : 2021-12-13 DOI: 10.31579/2642-9756/087
Kanika Chopra
Increasing incidence of Placenta accrete syndrome has become a worrisome issue due to its associated life-threatening complications for both the mother and the fetus. The ideal management for PAS disorder remains the matter of debate still. The critical step in its effective management being its suspicion knowing the underlying risk factors and its diagnosis in antenatal period. Still, cesarean hysterectomy remains the gold standard procedure with many newer conservative approaches under evaluation. Our basic aim behind writing this review is to highlight the recent changes in classifying and diagnosing PAS owing to the ever-increasing incidence of this catastrophic entity. Also, it will emphasize the well-established role of radical over conservative management and also all modalities used in conservative management so far.
胎盘增生综合征的发病率不断上升,这已成为一个令人担忧的问题,因为它会对母亲和胎儿造成危及生命的并发症。PAS障碍的理想治疗方法仍然是争论的焦点。有效管理的关键一步是怀疑其是否了解潜在的风险因素以及产前诊断。尽管如此,剖宫产子宫切除术仍然是金标准手术,许多新的保守方法正在评估中。我们撰写这篇综述的基本目的是强调由于这种灾难性实体的发病率不断增加,PAS分类和诊断方面最近发生的变化。此外,它还将强调激进而非保守管理的既定作用,以及迄今为止保守管理中使用的所有模式。
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引用次数: 0
Studying a Series of Morphofunctional Index Values in Athletes of Reproductive age 育龄运动员一系列形态功能指标值的研究
Pub Date : 2021-12-13 DOI: 10.31579/2642-9756/088
Bugaevsky Ka
The article presents the results of the study, the purpose of which was to determine and analyze the indicators of several morphofunctional index values, at the athletes of reproductive ages engaged in initially male sports, such as: heavy athletics, powerlifting, sambo struggle, boxing, pushing the kernel and hammer throwing.
本文提出了研究结果,目的是确定和分析育龄运动员在最初从事男性运动的几个形态功能指标值的指标,如:重型竞技、力量举、三宝搏斗、拳击、推核和掷锤。
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引用次数: 0
Clomiphene Citrate versus Letrozole for Induction of Ovulation in Infertile women having Polycystic Ovarian Syndrome (Randomized Controlled Trial) 克罗米芬与来曲唑对多囊卵巢综合征不孕妇女排卵的诱导作用(随机对照试验)
Pub Date : 2021-12-13 DOI: 10.31579/2642-9756/085
Abdel Rahman Mohammed Saleh, Mahmoud Youssef Ali Ahmed Abdalla, Nourhan Adel Abu Elfotouh Tantawy
Background: Polycystic ovary syndrome is a disorder but with unclear etiology that its diagnosis depends on exclusion of other etiologies with ovulatory disorders and androgen excess as congenital adrenal hyperplasia, 21-hydroxylase deficient non classic congenital adrenal hyperplasia (NCAH), adrenal or ovarian androgen-secreting tumors, disorders of adrenocortical dysfunction as Cushing’s disease, and abuse of androgenic or anabolic drugs. Polycystic ovary syndrome affects approximately 6-15% of women in reproductive age and constitutes 50% of the causes of infertility in women. Aim of the Work: To compare the efficacy of letrozole on ovulation induction to that of clomiphene citrate in women suffering polycystic ovary syndrome and the effect on the follicular maturation, endometrial thickness and pregnancy rate. This study was carried in the outpatient infertility clinic of Ain-Shams Maternity Hospital during the period from November 2020 till April 2021. Patients and Methods: This study included 80 infertile women diagnosed as having polycystic ovary syndrome. Women were randomized into two groups. Letrozole group (1) included 40 women who were given the aromatase inhibitor (Letrozole) orally in a 5mg dose daily from day 3 to day 7 of the menstrual cycle. While Clomiphene citrate group (2) included 40 women who were given the clomiphene citrate orally in 100mg dose daily from day 3 to day 7 of the menstrual cycle. All women were counseled and informed consent was obtained before recruitment. Results: In this study, ovulation rate was significantly more frequent in the Letrozole group (82.5%, 33 women reached ovulation successfully) than in Clomiphene citrate group (60%, 24 women reached ovulation successfully) within P value=0.024. Clomiphene citrate at a dose of 100mg showed more efficacies in the number of follicle ≥18mm than Letrozole at a dose of 5mg. In Letrozole group, the number of follicles (≥18mm in diameter) ranged from 1 to 2 with a Mean±SD= 1.4±0.65 and in Clomiphene citrate group, the number of follicles (≥18mm in diameter) ranged from 1 to 3 with a Mean±SD= 1.9± 0.41 (P value=0.0001). Conclusion: Letrozole can be considered as a first line treatment of anovulation in polycystic ovary syndrome. But, moreover studies including larger number of cases will further confirm the efficacy of letrozole versus clomiphene citrate in induction of ovulation, reaching to the optimum doses for aromatases inhibitors, more observation on endometrial thickness, incidence of pregnancy outcomes, incidence of abortion and incidence of congenital fetal malformations.
背景:多囊卵巢综合征是一种病因不明的疾病,其诊断取决于排除其他排卵障碍和雄激素过多的病因,如先天性肾上腺增生、21-羟化酶缺乏的非经典先天性肾上腺皮质增生(NCAH)、肾上腺或卵巢雄激素分泌肿瘤、,库欣病等肾上腺皮质功能紊乱,以及滥用雄激素或合成代谢药物。多囊卵巢综合征影响大约6-15%的育龄妇女,占妇女不孕原因的50%。本工作的目的:比较来曲唑和克罗米芬对多囊卵巢综合征妇女促排卵的效果,以及对卵泡成熟度、子宫内膜厚度和妊娠率的影响。这项研究于2020年11月至2021年4月在艾因沙姆斯妇产医院不孕不育门诊进行。患者和方法:本研究包括80名被诊断为多囊卵巢综合征的不孕妇女。妇女被随机分为两组。来曲唑组(1)包括40名女性,她们在月经周期的第3天至第7天口服芳香化酶抑制剂(来曲唑),每日5mg。而克罗米芬柠檬酸盐组(2)包括40名女性,她们在月经周期的第3天至第7天每天口服100mg剂量的克罗米芬。所有妇女都接受了咨询,并在招募前获得知情同意。结果:在本研究中,来曲唑组的排卵率(82.5%,33名女性成功排卵)明显高于克罗米芬组(60%,24名女性成功卵泡),P值=0.024。100mg剂量的克罗米芬对卵泡≥18mm的疗效优于5mg剂量的来曲唑。来曲唑组卵泡数(直径≥18mm)为1~2个,平均值±标准差=1.4±0.65;克罗米芬-柠檬酸盐组卵泡数≥18mm,为1-3个,平均数±标准差1.9±0.41(P值=0.0001)。结论:来曲唑可作为治疗多囊卵巢综合征无排卵的一线药物。但是,此外,包括大量病例在内的研究将进一步证实来曲唑与克罗米芬柠檬酸盐在促排卵、芳香化酶抑制剂达到最佳剂量、子宫内膜厚度、妊娠结局发生率、流产率和先天性胎儿畸形发生率方面的疗效。
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引用次数: 0
Assess the Effectiveness of Using Kangaroo Mother Care on Reducing Postpartum Bleeding among Laboring Women: A Randomized Control Trial 评估使用袋鼠妈妈护理减少分娩妇女产后出血的有效性:一项随机对照试验
Pub Date : 2021-11-05 DOI: 10.31579/2642-9756/092
H. Fouly
Background: Kangaroo Mother Care (KMC) is one of the important interventions that must be implemented immediately after birth, contributing to minimizing postpartum bleeding. Aim: To assess the effectiveness of using KMC in reducing postpartum bleeding among laboring women. Materials and Methods: A randomized controlled clinical trial (Posttest design) was used in the present study. The study was conducted in the labor and delivery unit at King Abdulaziz Medical City (KAMC), Jeddah. 100 laboring women were recruited for the study randomly and divided into two equal groups. The intervention group had KMC while the control group received routine hospital care. Results: The homogeneity is shown among the participants and approved as there is no significant difference between both groups according to socio-demographic and obstetric data. There were statistically significant differences between the intervention and control groups regarding the amount of blood loss related to KMC (p-value = 0.000). Also, a successful first breastfeeding was higher among the intervention group than the control group (p-value = 0.002). Conclusions: The mothers who had KMC immediately after birth had lesser amounts of blood loss and experienced early successful breastfeeding initiation and continuous education and training programs to all midwives and nurses working in the labor and delivery about the importance of implementing KMC.
背景:袋鼠妈妈护理(KMC)是产后必须立即实施的重要干预措施之一,有助于最大限度地减少产后出血。目的:评价KMC在分娩妇女中减少产后出血的有效性。材料和方法:本研究采用随机对照临床试验(试验后设计)。这项研究是在吉达阿卜杜勒阿齐兹国王医疗城(KAMC)的分娩室进行的。研究随机招募了100名劳动妇女,并将她们分为两组。干预组接受KMC治疗,对照组接受常规医院护理。结果:根据社会人口统计和产科数据,两组之间没有显著差异,因此参与者之间表现出了同质性,并得到了认可。干预组和对照组与KMC相关的失血量有统计学意义(p值=0.000),干预组的首次母乳喂养成功率高于对照组(p值=0.002)实施KMC。
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引用次数: 1
Reproductive History and Pregnancy incidence of Malian and Beninese Female Sex workers before and During Sex Work Practice 马里和贝宁女性性工作者在从事性工作之前和期间的生殖史和怀孕发生率
Pub Date : 2021-11-05 DOI: 10.31579/2642-9756/075
M. Alary
Aim/Background: To reduce maternal mortality (MM), access to family planning and reproductive health care services are key strategies. Access to and use by marginalized populations pose a substantial challenge. The objective of this study was to describe the reproductive history of female sex workers (FSWs) before and during sex work. Materials and methods: FSWs aged ≥18 years were recruited in Benin, and Mali, to answer a questionnaire during a face-to-face interview. Descriptive analyses were carried out and comparisons made between countries (Pearson chi-square) and between the periods before (BSW) and during sex work (DSW) practice within women in each country (McNemar chi-square). In addition, multiple imputations were used to estimate and compare the incidence rate of pregnancy BSW and DSW calculated with a generalized linear model for count data with a Poisson distribution and a log link. Results: Mean age was 26 years in Mali (n=322) and 35 years in Benin (n=330). More women had at least one pregnancy BSW compared to DSW in both Mali (62.1%-vs-33.5%) and Benin (91.2%-vs-32.7%). The pregnancies occurring DSW had lower livebirth rates (57.9%-vs-74.7% Mali, 17.6%-vs-60.6% Benin) and ended more often with a therapeutic abortion, DSW compared to BSW, especially in Benin (65.2%-vs-25.6%). The level of complications associated with therapeutic abortion was high, both DSW (23%) and BSW (20%). The incidence rate of pregnancy was about twice lower DSW compared to BSW [incidence rate ratio (IRR): 0.49; 95% confidence interval (95%CI): 0.37-0.66-Mali and IRR: 0.45; 95% CI: 0.32-0.63-Benin]. Conclusion: In both Benin and Mali, FSWs had more pregnancies during the period preceding sex work practice, about twice more than during sex work when considering the differences in incidence rates. Single mothers need to be supported to avoid sex work as a financial solution. On the other hand, the reproductive needs of FSWs need to be acknowledged to reduce maternal mortality within this marginalized population. It is of paramount importance that interventions remain focused on reproductive health and prevent unwanted pregnancies, answer contraceptive needs and provide safe therapeutic abortions.
目的/背景:为了降低孕产妇死亡率,获得计划生育和生殖保健服务是关键战略。边缘化人口获得和使用是一项重大挑战。本研究的目的是描述女性性工作者在性工作之前和期间的生殖史。材料和方法:在贝宁和马里招募年龄≥18岁的FSW,在面对面访谈中回答问卷。进行了描述性分析,并对各国妇女进行了比较(皮尔逊卡方)、性工作前(BSW)和性工作期间(DSW)(McNemar卡方)。此外,还使用多个输入来估计和比较妊娠BSW和DSW的发生率,这些发生率是用具有泊松分布和对数链接的计数数据的广义线性模型计算的。结果:马里平均年龄为26岁(n=322),贝宁平均年龄为35岁(n=330)。与马里(62.1%vs-33.5%)和贝宁(91.2%vs-32.7%)的DSW相比,更多的妇女至少有一次妊娠BSW。发生DSW的妊娠活产率较低(57.9%vs-74.7%马里,17.6%-vs-60.6%贝宁),与BSW相比,DSW更经常以治疗性流产结束,尤其是在贝宁(65.2%vs-25.6%)。与治疗性流产相关的并发症水平较高,DSW(23%)和BSW(20%)。妊娠发生率DSW比BSW低约两倍[发病率比(IRR):0.49;95%置信区间(95%CI):0.37-0.66-Mali和IRR:4.45;95%CI:0.32-0.63-Benin]。单身母亲需要得到支持,以避免性工作作为经济解决方案。另一方面,需要承认FSW的生殖需求,以降低这一边缘化人群的孕产妇死亡率。至关重要的是,干预措施应继续侧重于生殖健康,防止意外怀孕,满足避孕需求,并提供安全的治疗性堕胎。
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引用次数: 2
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Women health care and issues
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