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The ACE2 COVID-19 target in Alzheimer’s disease ACE2 COVID-19在阿尔茨海默病中的靶点
Pub Date : 2021-08-30 DOI: 10.34297/ajbsr.2021.14.001951
Daniela A Gutiérrez
The COVID-19 pandemic is caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2). SARS-CoV-2 spike proteins target the angiotensin-converting enzyme 2 (ACE2) receptors localized mainly in the lungs. Recent studies have shown that SARS-CoV-2 also targets the CNS neurons and glial cells, triggering a cytokine immune-inflammatory response, compromising the blood-brain barrier, and ultimately causing neuronal death [1,2]. Thus, neurological diseases like Alzheimer’s disease (AD) are a particular comorbidity for COVID-19.
新冠肺炎大流行是由严重急性呼吸综合征冠状病毒(SARS-CoV-2)引起的。严重急性呼吸系统综合征冠状病毒2型刺突蛋白靶向主要定位于肺部的血管紧张素转换酶2(ACE2)受体。最近的研究表明,严重急性呼吸系统综合征冠状病毒2型还靶向中枢神经系统神经元和神经胶质细胞,引发细胞因子免疫炎症反应,破坏血脑屏障,最终导致神经元死亡[1,2]。因此,阿尔茨海默病(AD)等神经系统疾病是新冠肺炎的一种特殊合并症。
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引用次数: 0
The Influence of Short-term Restriction of Unilateral First Metatarsophalangeal Joint on the Contralateral Lower Limb Joints 单侧第一跖骨指关节短期限制对对侧下肢关节的影响
Pub Date : 2021-08-30 DOI: 10.34297/ajbsr.2021.14.001948
Z. Wang
To study the effect of restriction of unilateral movement of the first metatarsophalangeal joint (FMJ) on the biomechanics and gait of the contralateral lower limb. 8 adult college students completed walking with barefoot and left foot FMJ constraint (FMJC) respectively. The time node for collecting gait and biomechanical parameters is (I) 0min barefoot walking, (II) Walk immediately with FMJC at 0min, (III) walk after 30min with FMJC, (IV) walk barefoot after 30min with FMJC; Calculate the gait parameters on the contralateral side of the FMJC, the net joint torque and the joint moment arms of the hip, knee and ankle joints. Compared with the time node I, the maximum dorsiflexion angle and the maximum plantar flexion angle of the unrestricted side ankle joint at time node III increased significantly (p<0.05), and the maximum plantar flexion moment and maximum dorsiflexion moment increased significantly (p<0.05), the power of the ankle joint increased significantly (p<0.05); the torque and power of the hip and knee joints on the unrestricted side increased significantly (p<0.05); On the unrestricted side, there was no significant difference in stride length, swing phase, support phase and step length (p>0.05). Short-term unilateral FMJC will cause biomechanical compensation and compensation transmission in the unrestricted lower limb joints. That is, the unrestricted hip, knee, and ankle joints maintain normal gait by strengthening their work, and the transmission of compensation is enhanced from top to bottom.
目的:研究限制第一跖趾关节单侧活动对对侧下肢生物力学和步态的影响。8名成年大学生分别完成赤脚步行和左脚FMJ约束(FMJC)。采集步态和生物力学参数的时间节点为(I)赤脚步行0min, (II)在0min立即用FMJC步行,(III)在30min后用FMJC步行,(IV)在30min后用FMJC赤脚步行;计算FMJC对侧的步态参数、髋关节、膝关节和踝关节的净关节力矩和关节力矩臂。与时间节点I相比,时间节点III无约束侧踝关节最大背屈角和最大足底屈角显著增加(p0.05)。短期单侧FMJC会引起无限制下肢关节的生物力学补偿和补偿传递。即不受限制的髋关节、膝关节、踝关节通过加强工作来维持正常的步态,从上到下加强补偿传递。
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引用次数: 0
One-Pot Efficient Synthesis of 1,4-Bis (2,2′:6′,2′′-Terpyridin-4′-Yl) Benzene Ditopic Bridging Ligand 一锅法高效合成1,4-双(2,2′:6′,2′-三吡啶-4′-Yl)苯双位桥配体
Pub Date : 2021-08-30 DOI: 10.34297/ajbsr.2021.14.001947
R. Zibaseresht
One-Pot Efficient Synthesis of 1,4-Bis (2,2′:6′,2′′-Terpyridin-4′-Yl) Benzene Ditopic Bridging Ligand. Abstract The ditopic bridging 1,4-bis(2,2′:6′,2′′-terpyridin-4′-yl) benzene (I) was prepared in a controlled one-pot condensation reaction of acetylpyri - dine, benzene-1,4-dicarbaldehyde and ammonium acetate in basic medium in EtOH in high yield. The product was characterised using conventional methods.
一锅法高效合成1,4-双(2,2′:6′,2′-三吡啶-4′-Yl)苯双位桥配体。摘要以乙酰吡啶、苯-1,4-二甲醛和乙酸铵为原料,在碱性介质中,在EtOH中控制一锅缩合反应,制备了双位桥接1,4-双(2,2′:6′,2′-联吡啶-4′-基)苯(I)。使用常规方法对产品进行表征。
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引用次数: 0
Coagulation Profile In COVID-19 COVID-19的凝血特征
Pub Date : 2021-08-30 DOI: 10.34297/ajbsr.2021.14.001953
A. Kashif
Objective: To evaluate the coagulation profile in COVID-19 patients and to correlate disease severity with the coagulation parameters. Methodology: This retrospective study was conducted at Pathology and medicine departments, FMH College of Medicine and Dentistry. It included 101 confirmed cases of COVID-19 disease of both genders between 17 and 75-year age. Coagulation profile was compared between survivor and non-survivor groups. Results: Out of 101 patients, 93 (92.1%) patients were in the survivor group and eight (7.8%) in the non-survivor group. Mean APTT (p = 0.02) in non-survivor group showed relatively higher values than survivor group. Mean D-Dimers (p = 0.007) in non-survivors showed a significantly raised values. However other parameters of coagulation like Platelets, MPV, PT and INR showed no significant association statistically. Conclusion: High D-dimers and prolonged APTT were associated with mortality in COVID-19 Patients.
目的:评估新冠肺炎患者的凝血特征,并将疾病严重程度与凝血参数相关联。方法:这项回顾性研究在FMH医学和牙科学院病理学和医学系进行。其中包括101例17岁至75岁的新冠肺炎确诊病例。比较存活组和非存活组的凝血情况。结果:在101名患者中,93名(92.1%)患者属于幸存者组,8名(7.8%)患者属于非幸存者组。非幸存者组的平均APTT(p=0.02)显示出相对高于幸存者组的值。非幸存者的平均D-二聚体(p=0.007)显示出显著升高的值。然而,其他凝血参数,如血小板、MPV、PT和INR,在统计学上没有显示出显著的相关性。结论:高D-二聚体和延长APTT与新冠肺炎患者的死亡率相关。
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引用次数: 0
Nanotheranostics-An Emerging Technique in Nanomedicine 纳米肿瘤学——纳米医学的新兴技术
Pub Date : 2021-08-27 DOI: 10.34297/ajbsr.2021.14.001945
N. Khan
Nanotheranostics is a novel yet developing field which promises advanced methods for clinical diagnostics and treatment. Certain biological molecules present inside human body and their varying concentrations are used as detectable signals for nanoparticles or nanoconjugates to identify cancerous or tumors cells and also targeting these effected cells for the treatment of disease. At present, available treatments are expensive, time consuming with potential side effects. Therefore, application of nanotheranostics will surely help to minimize such issues and promises better therapeutics in nanomedicine
纳米肿瘤学是一门新兴的领域,有望为临床诊断和治疗提供先进的方法。存在于人体内的某些生物分子及其不同浓度被用作纳米颗粒或纳米偶联物的可检测信号,以识别癌细胞或肿瘤细胞,并针对这些受影响的细胞进行疾病治疗。目前,可用的治疗方法既昂贵又耗时,而且有潜在的副作用。因此,纳米治疗学的应用将有助于减少这些问题,并为纳米医学提供更好的治疗方法
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引用次数: 0
Quantum Management of Hospital in the Post-COVID-19 新冠肺炎疫情后医院量子管理
Pub Date : 2021-08-27 DOI: 10.34297/ajbsr.2021.14.001946
Fahri Ozsungur
The aim of this study is to present a management approach to transforming the deficiencies in crisis management during the pandemic period into a strong facet of businesses. In this research, phenomenology and grounded theory were adopted. The results of the study revealed five basic principles in the form of quantum management of hospital management: Infinity of possibilities, resilience to waves of uncertainty and making sense, the complementarity of diversity and complexity, significance of chaos and crisis, interactive outputs. These basic principles are under the influence of three basic factors based on medical, administrative, sharing-interaction.
本研究的目的是提出一种管理方法,将大流行期间危机管理的缺陷转化为企业的一个强有力的方面。本研究采用现象学与扎根理论相结合的方法。研究结果揭示了医院管理的量子管理形式的五个基本原则:无限的可能性,对不确定性和有意义浪潮的弹性,多样性和复杂性的互补性,混乱和危机的重要性,互动输出。这些基本原则受到医疗、行政、共享互动三个基本因素的影响。
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引用次数: 0
The Swedish Elderly and Psychiatric Healthcare as Models: An Investigation into the Social Importance of Healthcare and Biomedical Science Research 以瑞典老年人和精神卫生保健为榜样:卫生保健和生物医学研究的社会重要性调查
Pub Date : 2021-08-26 DOI: 10.34297/ajbsr.2021.14.001944
D. Ayim-Aboagye
Sweden continues to enjoy the elderly and psychiatric healthcare in its welfare state. This development could not have been successful without the hard work of biomedical scientists and their researchers. We investigate in this study the involvement of biomedical research, its personnel and the way it has championed new knowledge and confidence in the industries as a whole. Moreover, the psychiatric work in prison institutions is investigated to find out how inmates are being helped by these professionals to deal with their guilt.
瑞典继续在其福利国家中享受老年人和精神病保健。如果没有生物医学科学家及其研究人员的辛勤工作,这一发展是不可能成功的。在这项研究中,我们调查了生物医学研究的参与、其人员以及它在整个行业中倡导新知识和信心的方式。此外,还调查了监狱机构的精神病学工作,以了解这些专业人员如何帮助囚犯处理他们的内疚。
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引用次数: 0
Finite Element Analysis of Total Knee Arthroplasty 全膝关节置换术的有限元分析
Pub Date : 2021-08-25 DOI: 10.34297/ajbsr.2021.14.001942
Mohammad Noori
Total knee arthroplasty (TKA) has become one of the most common operations in all of medicine, with an average of 966,000 performed annu - ally in the United States. Since its introduction in 1968, TKA surgical techniques and implant designs have improved to increase prosthesis longevity. However, aseptic loosening of TKA components continues to be the most common reason for revision surgery. Ideal implant characteristics, which minimize stress shielding have yet to be determined. The purpose of this study was to investigate how implant design parameters including fixation technique, tibial stem geometry, cement stiffness, and implant-bone frictional interface affect stress shielding within the tibia, and to determine the optimal combination that minimizes this effect. A CT scan of a tibia was used to simulate multiple tibial stem configurations for finite element analysis in ABAQUS. Stress shielding was calculated by using the average minimum principal stress at interval cuts along the length of the tibia. We found that short, fully-cemented stems, high-stiffness hybrid cemented stems, low-stiffness for fully-cemented stems, and a sliding friction interface to be ideal.
全膝关节置换术(TKA)已成为所有医学中最常见的手术之一,在美国平均每年进行966000次。自1968年推出以来,TKA手术技术和植入物设计得到了改进,以延长假体的使用寿命。然而,TKA组件的无菌性松动仍然是翻修手术最常见的原因。将应力屏蔽降至最低的理想植入物特性尚未确定。本研究的目的是研究植入物设计参数(包括固定技术、胫骨干几何形状、水泥刚度和植入物-骨摩擦界面)如何影响胫骨内的应力屏蔽,并确定将这种影响降至最低的最佳组合。胫骨的CT扫描用于模拟ABAQUS中的多个胫骨干配置进行有限元分析。应力屏蔽是通过使用沿胫骨长度的间隔切口处的平均最小主应力来计算的。我们发现,较短的全胶结阀杆、高刚度混合胶结阀杆、低刚度全胶结阀杆以及滑动摩擦界面是理想的。
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引用次数: 0
Assessment of Oxytetracycline Residue in Table Eggs from Khartoum State’s Markets 喀土穆州市场餐蛋中土霉素残留量的评估
Pub Date : 2021-08-25 DOI: 10.34297/ajbsr.2021.14.001941
Sara Am
Background: Antibiotics residue in food from animal origin represents a public health issue concerns the authorities worldwide. Method: 100 egg samples were collected from Khartoum state’s markets to evaluate the current situation of oxy tetracycline residue. briefly, Samples were homogenized, weighed (2 g); and processed by adding citric acid (100 mg), 30% nitric acid (1 ml), methanol (4 ml) followed by adding 1 ml of deionized water; then centrifuged at 5300 for 10 mints followed by filtration throughout 0.22 µm syringe filter and 20 µl of the sample was injected into HPLC equipped with UV-VIS detector and ODS (C-18) column and read at 360 nm. Result: 49 % of total samples were positive. 48% of those positive samples (24 out of 49); were equal or exceeded the MRL of Oxytetracycline in egg (200 ppb). The mean values obtained from the three different state’s cities were not significantly different between different localities, never theless between each city and the MRL the variance was vastly significant.
背景:动物源性食品中抗生素残留是世界各地当局关注的公共卫生问题。方法:从喀土穆州市场采集100份鸡蛋样品,对土霉素残留现状进行评价。简单地说,将样品均化,称重(2g);并通过加入柠檬酸(100 mg)、30%硝酸(1 ml)、甲醇(4 ml),然后加入1 ml去离子水进行处理;然后在5300下离心10分钟,然后通过0.22µm注射器过滤器过滤,将20µl样品注入配备UV-VIS检测器和ODS(C-18)柱的HPLC中,并在360nm下读取。结果:49%的标本呈阳性。48%的阳性样本(49个样本中有24个);等于或超过土霉素在鸡蛋中的MRL(200ppb)。从三个不同州的城市获得的平均值在不同地区之间没有显著差异,即使每个城市与MRL之间的差异也非常显著。
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引用次数: 0
Clostridium Difficile Pathogenicity Mechanism Associated with Dysbiosis Caused by The Use of Antibacterials 使用抗菌药物引起的难产梭菌致病机制
Pub Date : 2021-08-24 DOI: 10.34297/ajbsr.2021.13.001938
Ana María Valencia Castaño
Clostridium difficile is a gram-positive rod responsible for the majority of hospital-acquired gastrointestinal infections in humans. Recently in the world literature an exponential increase in its incidence has been reported, involving new more virulent strains that affect new groups of patients that were previously unaffected, generating a series of changes in the clinical presentation of the disease and in the treatment, which influ- ences the prognosis of the disease in these patients. An early diagnosis is essential for therapeutic management and for the implementation of con-tainment measures. However, the speed with which new strains with greater pathogenicity are developed is higher than that with which new drugs are developed to combat them, all this as a result of the irrational use of antibiotics that alter the pathogenicity mechanism of this type of bacteria. In this article we review the pathophysiological aspects of C. difficile infection associated with dysbiosis caused by the use of antibacterials, with the aim of contributing to the preparation of general practitioners and specialists to provide timely and quality care to those who receive it. suffer from this disease and make a more rational use of antibiotics.
艰难梭菌是一种革兰氏阳性杆菌,是人类大多数医院获得性胃肠道感染的原因。最近,世界文献报道其发病率呈指数级增长,涉及新的毒性更强的菌株,这些菌株会影响以前未受影响的新患者群体,在疾病的临床表现和治疗中产生一系列变化,从而影响这些患者的疾病预后。早期诊断对于治疗管理和娱乐措施的实施至关重要。然而,致病性更强的新菌株的开发速度高于对抗它们的新药的开发速度,这一切都是由于不合理地使用抗生素改变了这类细菌的致病机制。在这篇文章中,我们回顾了艰难梭菌感染与使用抗菌药物引起的生态失调相关的病理生理学方面,目的是为全科医生和专家做好准备,为接受治疗的人提供及时和高质量的护理。患有这种疾病并更合理地使用抗生素。
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引用次数: 0
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American journal of biomedical science & research
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