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Complex techniques of eyelid reconstruction following extensive basal cell carcinoma resection 基底细胞癌大面积切除后眼睑重建的复杂技术
Pub Date : 2021-06-10 DOI: 10.21037/FOMM-21-11
A. Rokohl, A. Kopecký, P. A. W. Matos, Yongwei Guo, V. Kakkassery, L. Heindl
Basal cell carcinoma (BCC) is one of the most common malignant tumors overall and even the most common malignant tumors in ophthalmology. In most cases, surgical resection followed by an ophthalmoplastic reconstruction is the current gold standard for the treatment of periocular BCC. Histopathologic analysis can be performed both as a frozen section examination, Mohs micrographic surgery, or as a rapid embedding analysis, depending on the surgeon’s preference or the in-house standard. A histopathologic workup is essential not only for confirming the diagnosis and determining resection status but especially for identifying infiltrating growing subtypes, as this also influences postoperative follow-up and prognosis. A wide range of various reconstruction methods allow individualized defect coverage with mostly good cosmetically and functionally results. The basic principle is to restore the anatomy with an anterior and posterior eyelid lamella. The selection of the appropriate technique depends not only on the vertical and horizontal defect size, defect localization, or potential eyelid edge involvement but also significantly on the patient’s age, available tissue (e.g., skin), the patient’s preference, and especially the surgeon’s experience. For smaller, partial, or penetrating defects, direct wound closure can be performed. However, for greater defects more complex reconstruction techniques including Tenzel’s rotational plasty, Hughes flap, CutlerBeard plastic, Mustardé lid Switch flap, tarsomarginal grafts according to Huebner, or V-Y glabella flap are necessary, dependently on the size and the location of the defect. However, in advanced findings with infiltration of the orbit, orbital exenteration is unavoidable in some cases. Postoperative regular follow-up is essential to identify potential complications in an early stage.
基底细胞癌(Basal cell carcinoma, BCC)是最常见的恶性肿瘤之一,也是眼科最常见的恶性肿瘤。在大多数情况下,手术切除后眼球成形术重建是目前治疗眼周基底细胞癌的金标准。组织病理学分析既可以作为冷冻切片检查,莫氏显微摄影手术,也可以作为快速包埋分析,这取决于外科医生的偏好或内部标准。组织病理学检查不仅对于确认诊断和确定切除状态至关重要,而且对于确定浸润性生长亚型尤为重要,因为这也影响术后随访和预后。广泛的各种重建方法允许个性化的缺陷覆盖,大多数是良好的美容和功能的结果。基本原理是用前、后睑板恢复解剖结构。选择合适的技术不仅取决于垂直和水平缺损的大小、缺损的位置或潜在的眼睑边缘受损伤,而且还取决于患者的年龄、可用的组织(如皮肤)、患者的偏好,尤其是外科医生的经验。对于较小的、局部的或穿透性的缺陷,可以直接缝合伤口。然而,对于更大的缺陷,根据缺陷的大小和位置,需要更复杂的重建技术,包括Tenzel旋转成形术、Hughes皮瓣、cultlerbeard塑料、mustardshall lid Switch皮瓣、Huebner的睑缘移植物或V-Y眉骨瓣。然而,在眼眶浸润的晚期发现,在某些情况下,眼眶摘除是不可避免的。术后定期随访对于早期发现潜在并发症至关重要。
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引用次数: 0
Long-term skeletal stability following orthognathic surgery with counter-clockwise and clockwise rotation of the maxillo-mandibular complex: report of three cases 顺时针和逆时针旋转正颌复合体手术后的长期骨骼稳定性:三例报告
Pub Date : 2021-03-01 DOI: 10.21037/FOMM-20-32
Rafael Correia Cavalcante, Otávio Giambarresi Delorenzi, L. Klüppel
: The aim of the present study is to evaluate the long-term postoperative skeletal stability after orthognathic surgery with counter-clockwise rotation (CCWR) or with clockwise rotation (CWR) of the maxillo-mandibular complex. Three patients were submitted to orthognathic surgery associated with CCWR and CWR. Lateral cephalometric radiographs were obtained in centric relation for each patient, one day before surgery (T1), 1 week after surgery (T2) and 1 year after surgery (T3). Cephalometric angles analysed were: SN-OP, SN-A, SN-B, SN-Pg, and SN-Ar. Angular changes on occlusal plane (OP), condylar position, maxilar, mandibular, and pogonium prognathism were analysed. Maxilar, mandibular, and pogonium prognathism linear changes were also recorded in millimeters. Patients had no signs and symptoms of temporo-mandibular joints pathology. Patients 1 and 2 were submitted to orthognathic surgery with CCWR. Patient 1 presented an OP decrease on T2, from 6.37° to 4.01°. On T3, however, a 2.17° relapse was observed. Patient 2 presented an OP decrease on T2, from 8.14° to 3.45°. On T3, however, a 0.54° relapse was observed. Patient 3 was submitted to orthognathic surgery with CWR. It was observed an increase in OP angulation on T2, from 6.16° to 16.13°. On T3, however, it was observed a 7.57° relapse. Regarding OP stability following orthognathic surgery with CCWR and CWR, results of the present article are consistent with of some previous published studies. More cases should be followed and more research in this area are necessary to validate these approaches to avoid unsuccessful cases or to anticipate unwanted results. vertical maxillary hypoplasia; anteroposterior mandibular hypoplasia; high mandibular plane angulation; and Class I, Class II (most common), or Class III malocclusion with or without an anterior bite. HOP individuals may benefit from a MMC counterclockwise rotation (CCWR). LOP facial type presents some features: decreased OP angle (<4°); low mandibular plane angle; prominent mandibular gonial angles; strong chin relative to mandibular dental alveolus; and Class I, Class II, or occasionally Class III relationships. Individuals with LOP facial types may benefit from a MMC clockwise rotation (CWR). Maxillo-mandibular complex is routinely expressed by a triangle, which can be rotated in or counter-clockwise
本研究的目的是评估逆时针旋转(CCWR)或顺时针旋转(CWR)正颌手术后的长期骨骼稳定性。3例患者接受与CCWR和CWR相关的正颌手术。术前1天(T1)、术后1周(T2)、术后1年(T3),以中心关系拍摄每位患者侧位头颅x线片。分析的头测角为:SN-OP、SN-A、SN-B、SN-Pg和SN-Ar。分析了牙合平面(OP)、髁突位置、上颌、下颌和前突角的角度变化。上颌、下颌骨和下颌前突的线性变化也以毫米为单位记录。患者无颞下颌关节病理症状和体征。患者1和2接受CCWR正颌手术。患者1 T2上OP降低,从6.37°降至4.01°。然而,在T3时,观察到2.17°的复发。患者2在T2上OP降低,从8.14°降至3.45°。然而,在T3时,观察到0.54°的复发。患者3接受CWR正颌手术。观察到T2的OP角度从6.16°增加到16.13°。然而,在T3时,观察到7.57°的复发。关于CCWR和CWR正颌手术后的OP稳定性,本文的结果与先前发表的一些研究结果一致。应该跟踪更多的病例,并在这一领域进行更多的研究,以验证这些方法,以避免不成功的病例或预期不希望的结果。上颌垂直发育不全;下颌前后发育不全;下颌平面高角;和I类,II类(最常见),或III类错合,有或没有前咬合。HOP个体可能受益于MMC逆时针旋转(CCWR)。LOP面部类型表现为OP角减小(<4°);下颌低平面角;突出的下颌角;相对于下颌牙槽强壮的下巴;以及I类、II类或偶尔III类关系。LOP面部类型的个体可能受益于MMC顺时针旋转(CWR)。上颌复合体通常用三角形表示,可以顺时针或逆时针旋转
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引用次数: 0
Edentulism (missing teeth) and brain central nervous system (CNS) deafferentation: a narrative review 无牙症(缺牙)和脑中枢神经系统(CNS)神经分化:叙述回顾
Pub Date : 2021-01-01 DOI: 10.21037/fomm-21-117
Dani Stanbouly, Qingcong Zeng, Y. Jou, S. Chuang
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引用次数: 0
Different responses of heterogeneous graft presentations in bone reconstructions during sinus lift elevation surgery: an immunolabeling and histomorphometric study performed in rabbits 异种移植物在上颌窦抬高手术骨重建中的不同反应:在兔身上进行的免疫标记和组织形态计量学研究
Pub Date : 2021-01-01 DOI: 10.21037/fomm-21-45
N. Siqueira, Ana Cláudia Ervolino da Silva, R. Pereira, E. Hochuli-Vieira, P. N. Lisboa-Filho, Ciro Borges Duailibe de Deus, R. Okamoto
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引用次数: 2
Oral rehabilitation through the application of a xenogenous bone graft prior to placement of a dental implant: a case report with 9 years of follow-up 在植牙前应用异种骨移植物进行口腔康复:一个9年随访的病例报告
Pub Date : 2021-01-01 DOI: 10.21037/fomm-21-46
Paulo Martins Ferreira, William Phillip Pereira da Silva, Felipe R. Ferreira, Gabriel Ramalho Ferreira, Paulo Fukasji Yamaguti, L. A. Delanora, A. Consolaro, L. Faverani
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引用次数: 0
Lessons learned from the multidisciplinary UK National Flap Registry initiative and plans for the future 从多学科的英国国家皮瓣注册倡议中吸取的经验教训和未来计划
Pub Date : 2021-01-01 DOI: 10.21037/fomm-21-2
Michael Ho, A. Schache, M. Nugent, A. Hazari
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引用次数: 1
The job to be done with biofilm and titanium implants 这项工作是用生物膜和钛植入物完成的
Pub Date : 2021-01-01 DOI: 10.21037/FOMM-21-54
O. Jensen, E. Weiss, D. Grainger
© Frontiers of Oral and Maxillofacial Medicine. All rights reserved. Front Oral Maxillofac Med 2021;3:21 | http://dx.doi.org/10.21037/fomm-21-54 Once, Clayton Christensen was asked about the prospect of starting a new dental implant company when there were already hundreds of implant companies around the world. “If you proceed,” he advised, “you have to ask one question: What is the job to be done?” Interestingly, the job to be done remains one that the dental profession has wrestled with from the beginning: to inhibit or arrest the development of microbial biofilms on titanium surfaces of an intraoral implant. The peculiarity of the oral cavity is that endogenous b a c t e r i a a n d f u n g u s — c o m m e n s a l , p a t h o g e n i c , opportunistic—all evolved a highly stable self-regulating, and often symbiotic, environment for the dentate niche, termed biofilm that supplements their planktonic growth strategy. A biofilm is a community of aggregated microbial cells organized as micro-communities, colonizing solid oral surfaces in contact with liquids and air. And this unique biofilm strategy is several orders of magnitude more resistant to natural sheer forces from deglutition, mastication and salivary flow that otherwise readily clear nonadherent pathogens from the mouth. The biofilm matrix comprises an aqueous network of mixed nucleic acids, polysaccharides, proteins and lipids, all of microbial origin. The interacting extracellular polymeric substances (EPS) are non-covalently associated into a robust matrix to embed and protect aggregated bacterial and fungal cells within the biofilm. Microbe-microbe, microbe-EPS, microbe-liquid/air, and microbe-substrate interactions all determine formation, properties and behaviors of biofilm. Polymicrobial biofilms are most common, representing complex dynamic communities of diverse, spatially aggregated organisms. One characteristic feature of biofilm is its physical barrier functions that provide microbial protection, particularly in the deeper layers. Biofilm protections are diverse, spanning microbial physical resistance to phagocyte engulfment and biofilm extraction, and reduced exposure to antimicrobials by limited biofilm permeation. Additionally, microbial density within EPS highly favors plasmid exchange, facilitating the transfer of resistance genes and virulence factors. Other genetic programming and regulation also occurs within biofilms, allowing populations of pathogens to undergo senescence to avoid susceptibility to metabolically targeted antimicrobials. Sleeper or persister cells re-awaken post-exposure to exert virulence. Furthermore, should the biofilm become mechanically or pharmacologically disrupted, they readily and rapidly reform in the oral cavity within several hours. Biofilm, therefore, is highly refractory to elimination from the oral niche. Importantly, commensal and probiotic endogenous oral biofilms are an essential component of oral health and therefore should not be
©口腔颌面医学前沿。版权所有。前口腔颌面医学2021;3:21 | http://dx.doi.org/10.21037/fomm-21-54有一次,克莱顿·克里斯滕森(Clayton Christensen)被问及创办一家新的牙科种植公司的前景,当时全球已经有数百家种植公司。“如果你要继续,”他建议说,“你必须问一个问题:你要做的工作是什么?”有趣的是,要做的工作仍然是牙科行业从一开始就在努力解决的问题:抑制或阻止口腔内种植体钛表面微生物生物膜的发展。口腔的独特之处在于,内源性的细菌、细菌、细菌、细菌、细菌、细菌、细菌、细菌等都进化出了一种高度稳定的、自我调节的、通常是共生的齿状生态位环境,这种环境被称为生物膜,补充了它们的浮游生长策略。生物膜是由聚集的微生物细胞组成的微群落,定植在与液体和空气接触的固体口腔表面。这种独特的生物膜策略对来自吞咽、咀嚼和唾液流动的自然力量的抵抗力要好几个数量级,否则这些力量很容易从口腔中清除非粘附性病原体。生物膜基质由混合的核酸、多糖、蛋白质和脂质组成的水性网络,所有这些都是微生物来源。相互作用的细胞外聚合物(EPS)非共价结合成一个强大的基质,以嵌入和保护生物膜内聚集的细菌和真菌细胞。微生物与微生物、微生物与eps、微生物与液体/空气以及微生物与基质的相互作用都决定了生物膜的形成、性质和行为。多微生物生物膜是最常见的,代表了不同的、空间聚集的生物的复杂动态群落。生物膜的一个特征是它的物理屏障功能,提供微生物保护,特别是在较深层。生物膜的保护是多种多样的,包括微生物对吞噬细胞吞噬和生物膜提取的物理抗性,以及通过限制生物膜渗透来减少对抗菌剂的暴露。此外,EPS内的微生物密度有利于质粒交换,促进抗性基因和毒力因子的转移。其他遗传编程和调控也发生在生物膜内,使病原体群体经历衰老,以避免对代谢靶向抗菌素的易感性。休眠细胞或持久细胞在暴露后重新唤醒以发挥毒性。此外,如果生物膜在机械上或药理学上受到破坏,它们会在几小时内迅速在口腔内重新形成。因此,生物膜很难从口腔生态位中消除。重要的是,共生和益生菌内源性口腔生物膜是口腔健康的重要组成部分,因此不应受到干扰。机会性、致病性口腔生物膜是口腔疾病和生态位妥协的来源。尽管对口腔健康和死亡的贡献各不相同,但所有生物膜在结构和生物学上都是口腔环境不可或缺的一部分。因此,有效缓解和选择性中和致病性口腔生物膜,同时保护和促进共生宿主有益的口腔生物膜是需要做的工作。恢复和维持益生菌平衡,促进健康的生物膜作为防御病原生物膜是一个重要的目标。在一定程度上,自然牙植入牙槽骨并植入支持的软组织附着物,可以自我清洁,并且当牙齿和颌骨结构对齐时,可以促进生物膜的静止平衡。但这种情况可能会变得不平衡
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引用次数: 0
Solitary mucosal neuroma of the gingiva without multiple endocrine neoplasia type 2B: a rare case report and literature review 无2B型多发性内分泌肿瘤的牙龈孤立性粘膜神经瘤:一例罕见病例报告和文献复习
Pub Date : 2021-01-01 DOI: 10.21037/fomm-20-80
C. Qiu, Lizhen Wang, Huiwen Chen, Zhongchen Song
Mucosal neuroma (MN) is a benign neural tumor of peripheral nerves histologically characterized by irregular tortuous bundles of nerve cells with prominent perineurium that lie scattered throughout the submucosa. The tumor is usually associated with the multiple endocrine neoplasia type 2B (MEN 2B) but rarely occurs without the other components of MEN 2B. A 29-year-old woman presented to our outpatient department with an upper anterior teeth gingiva painless mass for 2-year. Intraoral examination revealed a small, tough, basal wide, well-defined mass in the labial gingival papilla between maxillary central incisor. Excisional biopsy showed that it was characterized by nerve bundles in various sizes surrounded by normal connective tissue in the submucosa under HE staining; Immunohistochemically, the mass showed strongly positive staining of S-100 protein, NSE, NF and weakly positive of EMA. The Laboratory examination and ultrasonography showed no signs of MEN 2B. In the first and second 6 months of follow-up, there was no evidence of recurrence and other components of MEN 2B. The patient was asymptomatic and she is still being followed up every 6 months. Based on these features, the lesion was finally diagnosed as a solitary gingival MN. In summary, this study showed a rare solitary MN in the gingiva papilla without MEN 2B that has not been reported yet. The histopathological evaluation can be helpful in the differential diagnosis of MN. It is hoped that a greater understanding of solitary MN without MEN 2B in the oral cavity will avoid potential misdiagnosis, and contribute to determining the correct management, which appears to be complete surgical excision with close follow-up for recurrence and other components of MEN 2B surveillance.
粘膜神经瘤(MN)是周围神经的一种良性神经肿瘤,组织学特征为不规则扭曲的神经细胞束,神经周围膜突出,分散分布在粘膜下层。该肿瘤通常与多发性内分泌瘤2B型(MEN 2B)相关,但很少发生无MEN 2B其他成分的肿瘤。一名29岁女性,因上前牙牙龈无痛性肿块就诊2年。口腔内检查发现在上颌中切牙之间的唇龈乳头上有一个小的、坚韧的、基部宽的、界限清楚的肿块。切除活检示HE染色粘膜下层可见大小不等的神经束,周围为正常结缔组织;免疫组化结果显示S-100蛋白、NSE、NF呈强阳性,EMA呈弱阳性。实验室检查和超声检查未见MEN 2B征象。在第一个和第二个6个月的随访中,没有复发和其他MEN 2B成分的证据。患者无症状,仍在每6个月随访一次。基于这些特征,最终诊断为单纯性牙龈MN。综上所述,本研究发现一罕见的龈乳头单发MN,未见MEN 2B的报道。组织病理学评价有助于MN的鉴别诊断。我们希望通过对口腔内无MEN 2B的孤立性MN的更深入的了解,避免潜在的误诊,并有助于确定正确的治疗方法,即完全手术切除,密切随访复发和其他MEN 2B监测组成部分。
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引用次数: 0
The implant-abutment connection and its impact on prevention of peri-implant diseases and crestal bone stability—an academic and clinical evaluation of the literature 种植体-基台连接及其对预防种植体周围疾病和牙冠骨稳定性的影响-对文献的学术和临床评价
Pub Date : 2021-01-01 DOI: 10.21037/fomm-21-73
G. Romanos
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引用次数: 0
Narrative review: craniofacial bone regeneration—where are we now? 叙述性回顾:颅面骨再生-我们现在在哪里?
Pub Date : 2021-01-01 DOI: 10.21037/fomm-21-9
Hadi Khazaal, J. Helman
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引用次数: 2
期刊
Frontiers of oral and maxillofacial medicine
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