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Promoting R&D intentions in primary care organization through strategic communication 通过战略沟通促进基层医疗机构的研发意向
Pub Date : 2020-01-01 DOI: 10.15761/mri.1000171
Helena Morténius
We present a short paper based on a doctoral dissertation [1] and supplementary articles. Despite the long and successful patient care history of primary care in Sweden, a research-oriented attitude has been more or less limited in this context [2,3]. At the same time the patient ́s access to information has been simplified which in turn has contributed to an essential influence on the patients' demand for upto-date healthcare. This situation has increased the demand for staff ́s updated professional scientific knowledge and willingness to change significantly. One way to promote this situation goes through a research and development interest (R&D) in the context, by means of strategic communication, which is a relatively new interdisciplinary field.
我们在博士论文b[1]和补充文章的基础上发表了一篇简短的论文。尽管瑞典的初级保健有着悠久而成功的患者护理历史,但在这种背景下,以研究为导向的态度或多或少受到了限制[2,3]。同时,简化了患者获取信息的途径,这反过来又对患者对最新医疗保健的需求产生了重要影响。这种情况大大增加了对工作人员更新专业科学知识的需求和改变的意愿。促进这种情况的一种方法是通过战略沟通在背景下进行研究和开发兴趣(R&D),这是一个相对较新的跨学科领域。
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引用次数: 0
Virtual education during COVID -19 COVID -19期间的虚拟教育
Pub Date : 2020-01-01 DOI: 10.15761/MRI.1000175
Renu Bhupathy, Fauzia Nausheen
COVID-19, along with the associated mandated stay at home orders and social distancing, has affected all facets of society, including medical education. Although this is an unwelcomed pandemic, medical educators have been afforded a unique opportunity to investigate virtual learning options to deliver their customarily in-person curricula. The following is an insight from clinical educators about the adoption, transition, and challenges of clinical medical education in the virtual space.
COVID-19以及相关的强制性居家令和社交距离,已经影响到社会的各个方面,包括医学教育。虽然这是一场不受欢迎的大流行,但医学教育工作者已经获得了一个独特的机会来调查虚拟学习选项,以提供他们习惯的面对面课程。以下是临床教育工作者对虚拟空间中临床医学教育的采用、转型和挑战的见解。
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引用次数: 2
Some important considerations to support innovation in public health systems 支持公共卫生系统创新的一些重要考虑因素
Pub Date : 2020-01-01 DOI: 10.15761/MRI.1000177
D. Arya
Innovation in healthcare is a much-desired goal, however, unless the culture and environment are right and leaders proactively plan for innovation, not a lot changes. Both scientific and lay literature contains useful commentary on Innovation. It is useful to consider facilitators and barriers for innovation within healthcare systems, especially public health systems. The public healthcare system has some unique characteristics that can sometimes impede innovation. It is important to understand these complexities to be able to implement innovative solutions. Some strategies to implement innovation within the public health system are identified.
医疗保健领域的创新是一个非常理想的目标,然而,除非文化和环境是正确的,领导者主动为创新制定计划,否则不会有很大的变化。科学文献和非专业文献都包含对创新的有益评论。考虑卫生保健系统,特别是公共卫生系统内创新的促进因素和障碍是有益的。公共医疗保健系统有一些独特的特点,有时会阻碍创新。理解这些复杂性对于实现创新的解决方案非常重要。确定了在公共卫生系统内实施创新的一些战略。
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引用次数: 0
Fermentation of hemp seed proteins leads to formation of peptides that share sequence similarity with human vitamin D-binding protein 大麻籽蛋白的发酵导致与人类维生素d结合蛋白序列相似的肽的形成
Pub Date : 2020-01-01 DOI: 10.15761/mri.1000170
M. Ruggiero, S. Pacini
In this article, we describe how fermentation of hemp seed proteins leads to formation of peptides that share sequence similarities with human vitamin D-binding protein. We compared the amino acid sequence of edestin, the major hexameric globular protein from hemp protein isolates, with that of human vitamin D-binding protein, and we found significant functional similarities. Among the different peptides formed during the process of fermentation, we identified the peptide VLANAFQ of edestin as a promising candidate showing a high degree of functional similarity as well a common pattern of hydrophobicity with the TPTELAKLVNKRSE peptide that is the active site of human vitamin D-binding protein as far as it immune-stimulating, anti-proliferative and anti-migration properties are concerned.
在这篇文章中,我们描述了如何发酵大麻籽蛋白导致肽的形成,与人类维生素d结合蛋白共享序列相似性。我们比较了大麻蛋白分离物中主要的六聚体球状蛋白艾德素与人类维生素d结合蛋白的氨基酸序列,发现了显著的功能相似性。在发酵过程中形成的不同多肽中,我们发现edestin的肽VLANAFQ是一个很有希望的候选肽,它与人类维生素d结合蛋白的活性位点TPTELAKLVNKRSE肽具有高度的功能相似性和共同的疏水性模式,就其免疫刺激、抗增殖和抗迁移特性而言。
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引用次数: 0
Role of dietary factors in thyroid disorders: A primary care perspective 饮食因素在甲状腺疾病中的作用:初级保健视角
Pub Date : 2020-01-01 DOI: 10.15761/mri.1000172
Abu Bashar, Nazia Begam
Thyroid disorders are one of the most common endocrine problems seen at primary care. Role of dietary factors in their management and prevention is largely unknown with inadequate scientific evidences. In this review, we examine the scientific evidence of the role of various dietary elements in causation, prevention and management of thyroid disorders. meats. Typical sources in the diet are breads, grains, meat, poultry, fish, and eggs.
甲状腺疾病是初级保健中最常见的内分泌问题之一。饮食因素在其管理和预防中的作用在很大程度上是未知的,科学证据不足。在这篇综述中,我们研究了各种饮食元素在甲状腺疾病的病因、预防和管理中的作用的科学证据。肉类。饮食中典型的来源是面包、谷物、肉、家禽、鱼和蛋。
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引用次数: 1
Quantitative analysis of trace elements in Podocarpus nagi seeds 罗汉果种子中微量元素的定量分析
Pub Date : 2019-01-28 DOI: 10.15761/MRI.1000151
Yang Yang, O. Z. Olatunde, Jianping Yong, Canzhong Lu
Podocarpus nagi is a tree belonging to the family of Podocarpaceae, which has ever been used for treatment of trauma, stop-bleeding, fractures, knife wounds, gunshot wounds, body odor, eye diseases, colds and rheumatoid arthritis in clinic. Some compounds have been isolated and their biological activities were also evaluated. it’s seeds contains much oil and which can be used for food after refining or directly used industrially. In this work, the trace elements in the nuts, nut shell and oil residue were detected by the method of atomic absorption spectrum, which can provide reference for the further study. *Correspondence to: Jianping Yong, Xiamen Institute of Rare-earth Materials, Haixi Institute, Chinese Academy of Sciences, Xiamen, 361021, China, Tel: +86-591-63173162, E-mail: jpyong@fjirsm.ac.cn Canzhong Lu, Xiamen Institute of Rare-earth Materials, Haixi Institute, Chinese Academy of Sciences, Xiamen, 361021, China, Tel: +86-591-83705794, E-mail: czlu@fjirsm.ac.cn
罗汉果是罗汉果科的一种树木,临床上常用于治疗创伤、止血、骨折、刀伤、枪伤、狐臭、眼病、感冒和类风湿性关节炎。已经分离出一些化合物,并对它们的生物学活性进行了评价。它的种子含有大量的油,经过提炼后可以用作食品,也可以直接用于工业。本工作采用原子吸收光谱法对坚果、果壳和油渣中的微量元素进行了检测,为进一步研究提供了参考*通讯:中国科学院海西研究所厦门稀土材料研究所永建平,厦门,361021,电话:+86-591-63173162,电子邮件:jpyong@fjirsm.ac.cn陆灿忠,厦门稀土材料研究所,中国科学院海西研究所,厦门,361021,电话:+86-591-83705794,电子邮件:czlu@fjirsm.ac.cn
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引用次数: 0
Assessment the immune function of aged patients before and after immunotherapy in severe sepsis 评估老年重症脓毒症患者免疫治疗前后的免疫功能
Pub Date : 2019-01-01 DOI: 10.15761/mri.1000157
Hu Cong, Zheng Wei, Wang Wei, C. Lei, Zhong Jiwen, Z. Fan, Z. Ling
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引用次数: 0
Determination the trace elements in Aquilaria sinensis leave By ICP-MS ICP-MS法测定沉香叶中微量元素
Pub Date : 2019-01-01 DOI: 10.15761/mri.1000163
Yang Yang, Olagoke Zacchaeus Olatunde, Jianping Yong, Yuchen Xiao, Canzhong Lu
There are a lot of active components (amino acids, polysaccharides, saponins, alkaloids, flavonoids, organic acids and essential oils) and many trace elements in the leaves of A. sinensis . It has been reported that A. sinensis leaves were used as functional health tea. But till now, there is no report about the determination of the trance elements in the leaves of A. sinensis , we tested the trace elements in the leaves of A. sinensis using ICP-MS, to provide the valuable scientific evidence for the development of drinks .
冬青叶中含有大量的有效成分(氨基酸、多糖、皂苷、生物碱、黄酮类化合物、有机酸和精油)和多种微量元素。有报道称,金针叶被用作功能性保健茶。但到目前为止,尚没有关于白刺叶中微量元素测定的报道,本文采用ICP-MS对白刺叶中微量元素进行了测定,以期为饮料的开发提供有价值的科学依据。
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引用次数: 0
Comparative studies on the roles of calcium ions and gap Junctions in the regulation of secretory and contractile processes: Biochemical and pharmacologic approaches 钙离子和间隙连接在调节分泌和收缩过程中的作用的比较研究:生化和药理学方法
Pub Date : 2019-01-01 DOI: 10.15761/mri.1000153
Viktor I Goudochnikov
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引用次数: 0
An application and importance of production of medical radioisotopes used in cancer therapy and diagnosis 生产用于癌症治疗和诊断的医用放射性同位素的应用和重要性
Pub Date : 2019-01-01 DOI: 10.15761/MRI.1000155
O. Artun
This work points out importance of medical radioisotopes in nuclear medicine based on treatment and diagnosis of cancer. Moreover, possible production methods of medical radioisotopes are evaluated, and an application for the production of two medical radioisotopes through neutron and deuteron induced reaction processes is discussed by comparing with experimental data in the literature. *Correspondence to: Ozan Artun, Department of Physics, Zonguldak Bülent Ecevit University, Turkey, E-mail: ozanartun@beun.edu.tr / ozanartun@yahoo.com Received: March 12, 2019; Accepted: March 25, 2019; Published: March 28, 2019 Introduction Nuclear medicine plays an important role in diagnosis and treatment of cancerous cells using different devices some of which are Single Photon Emission Computed Tomography (SPECT), Positron Emission Tomography (PET), which are used in diagnostic aims [14]. Addition to diagnosis, cancer treatment is also available in nuclear medicine; however, the therapy can be separated two section as internal and external therapy. For instance, Intensity-modulated radiation therapy (IMRT) [5] that is a type of 3-D conformal radiation therapy [6] is an external therapy device. On the other hand, brachytherapy that is fairly important method can be called as internal therapy. In the literature, a lot of devices and methods to use medical radioisotopes in nuclear medicine are available in the literature. Common point of ones is definitely radioisotopes used in diagnosis and treatment of cancer, and these radioisotopes are produced by either nuclear reactors or particle accelerators via neutron reactions like (n,γ) or charged particle induced reaction processes e.g. proton, deuteron and alpha particles. Some of the famous radioisotopes produced in nuclear reactors may give Mo-99, P-32, Cu-64, Y-90 radioisotopes. Furthermore, medical radioisotopes produced by the charged particle induced reactions are commonly used in PET and SPECT. Such a production is carried out particle accelerators with energy ranges 1-50 MeV such as O-15, F-18, Ga-68 etc. But, for production of Ac-225 that is therapeutic purpose particle accelerators with higher energy are necessary [7]. Therefore, the production method of radioisotopes used in nuclear medicine can change kind of nuclei based on their half-lives and type of emission. For an application of the production of medical radioisotopes, we investigated the production of Kr-42 and Mn-51 radioisotopes via deuteron and neutron induced reaction processes. Materials and method The productions of K-42 and Mn-51 radioisotopes used for medical aims were carried out by neutron and deuteron induced reaction in energy region between 1 MeV and 30 MeV incident energy. Therefore, we used 45Sc(n,α)42K and 50Cr(d,n)51Mn reactions where the purities of the target materials are above 99% and each target is uniform [5,7,8]. The cross-section calculations were performed two component exciton models via TALYS 1.9 code [9] and the level
本文从癌症的治疗和诊断出发,指出了医用放射性同位素在核医学中的重要性。此外,对医用放射性同位素的可能生产方法进行了评价,并通过与文献实验数据的比较,讨论了利用中子和氘核诱导反应工艺生产两种医用放射性同位素的应用。*通讯作者:Ozan Artun,土耳其Zonguldak blent Ecevit大学物理系,E-mail: ozanartun@beun.edu.tr / ozanartun@yahoo.com录用日期:2019年3月25日;简介核医学在癌细胞的诊断和治疗中发挥着重要作用,使用不同的设备,其中一些是用于诊断目的的单光子发射计算机断层扫描(SPECT),正电子发射断层扫描(PET)。除了诊断之外,核医学还提供癌症治疗;然而,治疗可分为内外两部分。例如,调强放射治疗(IMRT)[5]是一种三维适形放射治疗[6]是一种外部治疗设备。另一方面,近距离治疗是一种相当重要的方法,可以称为内部治疗。在文献中,有很多在核医学中使用医用放射性同位素的装置和方法。它们的共同点肯定是用于癌症诊断和治疗的放射性同位素,这些放射性同位素由核反应堆或粒子加速器通过中子反应(n,γ)或带电粒子诱导反应过程(如质子,氘核和α粒子)产生。在核反应堆中产生的一些著名的放射性同位素可能产生Mo-99、P-32、Cu-64、Y-90等放射性同位素。此外,由带电粒子诱导反应产生的医用放射性同位素通常用于PET和SPECT。这种生产是在能量范围为1-50 MeV的粒子加速器上进行的,如O-15、F-18、Ga-68等。但是,为了生产用于治疗目的的Ac-225,需要更高能量的粒子加速器。因此,核医学中使用的放射性同位素的生产方法可以根据半衰期和发射类型来改变原子核的种类。为了医用放射性同位素生产的应用,我们研究了通过氘和中子诱导反应过程生产Kr-42和Mn-51放射性同位素。材料和方法在入射能量1 - 30 MeV之间的能量区,用中子和氘核诱导反应制备了医用放射性同位素K-42和Mn-51。因此,我们采用45Sc(n,α)42K和50Cr(d,n)51Mn反应,目标材料的纯度在99%以上,且各目标均匀[5,7,8]。横截面计算采用TALYS 1.9代码[9]进行双组分激子模型计算,能级密度模型选用恒温费米气体模型[1]。每个反应的计算结果与Exfor数据库[10]中的实验数据进行了比较。45Sc(n,α)42K和50Cr(d,n)51Mn反应的计算截面随入射能量的变化如图1和图2所示。在45Sc(n,α)42K反应中,Subasi et al.(1998)、Molla et al.(1998)、Doczi et al.(1998)、Bostan and Qaim(1994)、Grallert et al.(1993)、Belgaid et al.(1992)、Ikeda et al.(1988)、Levkovskii et al.(1969)、Bayhurst and Prestwood(1961)[11-19]测量了大量实验数据,显然计算截面与实验数据基本一致。特别是在中子入射能量14 MeV左右的最大截面值上,实验截面值高达70 MeV。此外,对于50Cr(d,n)51Mn反应,Klein等(2000)[20]报道的实验数据与从阈值到5 MeV的计算截面曲线吻合;但在5 MeV以上,实验数据高于理论截面曲线。另一方面,在5 MeV以内,实验值和理论值是一致的(图2)。结论本工作中,我们计算了中子和氘核诱导反应产生51Mn和42K放射性同位素,并将所得结果与文献数据中的实验数据进行了比较。计算数据与实验数据在确定入射能量的最大截面值上吻合较好。另外,为了产生51Mn放射性同位素,氘诱导反应在文献中没有足够的实验和理论结果。因此,我们可以为51Mn的生产提出新的实验和理论工作。 本文从癌症的治疗和诊断出发,指出了医用放射性同位素在核医学中的重要性。此外,对医用放射性同位素的可能生产方法进行了评价,并通过与文献实验数据的比较,讨论了利用中子和氘核诱导反应工艺生产两种医用放射性同位素的应用。*通讯作者:Ozan Artun,土耳其Zonguldak blent Ecevit大学物理系,E-mail: ozanartun@beun.edu.tr / ozanartun@yahoo.com录用日期:2019年3月25日;简介核医学在癌细胞的诊断和治疗中发挥着重要作用,使用不同的设备,其中一些是用于诊断目的的单光子发射计算机断层扫描(SPECT),正电子发射断层扫描(PET)。除了诊断之外,核医学还提供癌症治疗;然而,治疗可分为内外两部分。例如,调强放射治疗(IMRT)[5]是一种三维适形放射治疗[6]是一种外部治疗设备。另一方面,近距离治疗是一种相当重要的方法,可以称为内部治疗。在文献中,有很多在核医学中使用医用放射性同位素的装置和方法。它们的共同点肯定是用于癌症诊断和治疗的放射性同位素,这些放射性同位素由核反应堆或粒子加速器通过中子反应(n,γ)或带电粒子诱导反应过程(如质子,氘核和α粒子)产生。在核反应堆中产生的一些著名的放射性同位素可能产生Mo-99、P-32、Cu-64、Y-90等放射性同位素。此外,由带电粒子诱导反应产生的医用放射性同位素通常用于PET和SPECT。这种生产是在能量范围为1-50 MeV的粒子加速器上进行的,如O-15、F-18、Ga-68等。但是,为了生产用于治疗目的的Ac-225,需要更高能量的粒子加速器。因此,核医学中使用的放射性同位素的生产方法可以根据半衰期和发射类型来改变原子核的种类。为了医用放射性同位素生产的应用,我们研究了通过氘和中子诱导反应过程生产Kr-42和Mn-51放射性同位素。材料和方法在入射能量1 - 30 MeV之间的能量区,用中子和氘核诱导反应制备了医用放射性同位素K-42和Mn-51。因此,我们采用45Sc(n,α)42K和50Cr(d,n)51Mn反应,目标材料的纯度在99%以上,且各目标均匀[5,7,8]。横截面计算采用TALYS 1.9代码[9]进行双组分激子模型计算,能级密度模型选用恒温费米气体模型[1]。每个反应的计算结果与Exfor数据库[10]中的实验数据进行了比较。45Sc(n,α)42K和50Cr(d,n)51Mn反应的计算截面随入射能量的变化如图1和图2所示。在45Sc(n,α)42K反应中,Subasi et al.(1998)、Molla et al.(1998)、Doczi et al.(1998)、Bostan and Qaim(1994)、Grallert et al.(1993)、Belgaid et al.(1992)、Ikeda et al.(1988)、Levkovskii et al.(1969)、Bayhurst and Prestwood(1961)[11-19]测量了大量实验数据,显然计算截面与实验数据基本一致。特别是在中子入射能量14 MeV左右的最大截面值上,实验截面值高达70 MeV。此外,对于50Cr(d,n)51Mn反应,Klein等(2000)[20]报道的实验数据与从阈值到5 MeV的计算截面曲线吻合;但在5 Me
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Medical research and innovations
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