We present a short paper based on a doctoral dissertation [1] and supplementary articles. Despite the long and successful patient care history of primary care in Sweden, a research-oriented attitude has been more or less limited in this context [2,3]. At the same time the patient ́s access to information has been simplified which in turn has contributed to an essential influence on the patients' demand for upto-date healthcare. This situation has increased the demand for staff ́s updated professional scientific knowledge and willingness to change significantly. One way to promote this situation goes through a research and development interest (R&D) in the context, by means of strategic communication, which is a relatively new interdisciplinary field.
{"title":"Promoting R&D intentions in primary care organization through strategic communication","authors":"Helena Morténius","doi":"10.15761/mri.1000171","DOIUrl":"https://doi.org/10.15761/mri.1000171","url":null,"abstract":"We present a short paper based on a doctoral dissertation [1] and supplementary articles. Despite the long and successful patient care history of primary care in Sweden, a research-oriented attitude has been more or less limited in this context [2,3]. At the same time the patient ́s access to information has been simplified which in turn has contributed to an essential influence on the patients' demand for upto-date healthcare. This situation has increased the demand for staff ́s updated professional scientific knowledge and willingness to change significantly. One way to promote this situation goes through a research and development interest (R&D) in the context, by means of strategic communication, which is a relatively new interdisciplinary field.","PeriodicalId":93126,"journal":{"name":"Medical research and innovations","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67500496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
COVID-19, along with the associated mandated stay at home orders and social distancing, has affected all facets of society, including medical education. Although this is an unwelcomed pandemic, medical educators have been afforded a unique opportunity to investigate virtual learning options to deliver their customarily in-person curricula. The following is an insight from clinical educators about the adoption, transition, and challenges of clinical medical education in the virtual space.
{"title":"Virtual education during COVID -19","authors":"Renu Bhupathy, Fauzia Nausheen","doi":"10.15761/MRI.1000175","DOIUrl":"https://doi.org/10.15761/MRI.1000175","url":null,"abstract":"COVID-19, along with the associated mandated stay at home orders and social distancing, has affected all facets of society, including medical education. Although this is an unwelcomed pandemic, medical educators have been afforded a unique opportunity to investigate virtual learning options to deliver their customarily in-person curricula. The following is an insight from clinical educators about the adoption, transition, and challenges of clinical medical education in the virtual space.","PeriodicalId":93126,"journal":{"name":"Medical research and innovations","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67500107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Innovation in healthcare is a much-desired goal, however, unless the culture and environment are right and leaders proactively plan for innovation, not a lot changes. Both scientific and lay literature contains useful commentary on Innovation. It is useful to consider facilitators and barriers for innovation within healthcare systems, especially public health systems. The public healthcare system has some unique characteristics that can sometimes impede innovation. It is important to understand these complexities to be able to implement innovative solutions. Some strategies to implement innovation within the public health system are identified.
{"title":"Some important considerations to support innovation in public health systems","authors":"D. Arya","doi":"10.15761/MRI.1000177","DOIUrl":"https://doi.org/10.15761/MRI.1000177","url":null,"abstract":"Innovation in healthcare is a much-desired goal, however, unless the culture and environment are right and leaders proactively plan for innovation, not a lot changes. Both scientific and lay literature contains useful commentary on Innovation. It is useful to consider facilitators and barriers for innovation within healthcare systems, especially public health systems. The public healthcare system has some unique characteristics that can sometimes impede innovation. It is important to understand these complexities to be able to implement innovative solutions. Some strategies to implement innovation within the public health system are identified.","PeriodicalId":93126,"journal":{"name":"Medical research and innovations","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67500187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this article, we describe how fermentation of hemp seed proteins leads to formation of peptides that share sequence similarities with human vitamin D-binding protein. We compared the amino acid sequence of edestin, the major hexameric globular protein from hemp protein isolates, with that of human vitamin D-binding protein, and we found significant functional similarities. Among the different peptides formed during the process of fermentation, we identified the peptide VLANAFQ of edestin as a promising candidate showing a high degree of functional similarity as well a common pattern of hydrophobicity with the TPTELAKLVNKRSE peptide that is the active site of human vitamin D-binding protein as far as it immune-stimulating, anti-proliferative and anti-migration properties are concerned.
{"title":"Fermentation of hemp seed proteins leads to formation of peptides that share sequence similarity with human vitamin D-binding protein","authors":"M. Ruggiero, S. Pacini","doi":"10.15761/mri.1000170","DOIUrl":"https://doi.org/10.15761/mri.1000170","url":null,"abstract":"In this article, we describe how fermentation of hemp seed proteins leads to formation of peptides that share sequence similarities with human vitamin D-binding protein. We compared the amino acid sequence of edestin, the major hexameric globular protein from hemp protein isolates, with that of human vitamin D-binding protein, and we found significant functional similarities. Among the different peptides formed during the process of fermentation, we identified the peptide VLANAFQ of edestin as a promising candidate showing a high degree of functional similarity as well a common pattern of hydrophobicity with the TPTELAKLVNKRSE peptide that is the active site of human vitamin D-binding protein as far as it immune-stimulating, anti-proliferative and anti-migration properties are concerned.","PeriodicalId":93126,"journal":{"name":"Medical research and innovations","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67500485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thyroid disorders are one of the most common endocrine problems seen at primary care. Role of dietary factors in their management and prevention is largely unknown with inadequate scientific evidences. In this review, we examine the scientific evidence of the role of various dietary elements in causation, prevention and management of thyroid disorders. meats. Typical sources in the diet are breads, grains, meat, poultry, fish, and eggs.
{"title":"Role of dietary factors in thyroid disorders: A primary care perspective","authors":"Abu Bashar, Nazia Begam","doi":"10.15761/mri.1000172","DOIUrl":"https://doi.org/10.15761/mri.1000172","url":null,"abstract":"Thyroid disorders are one of the most common endocrine problems seen at primary care. Role of dietary factors in their management and prevention is largely unknown with inadequate scientific evidences. In this review, we examine the scientific evidence of the role of various dietary elements in causation, prevention and management of thyroid disorders. meats. Typical sources in the diet are breads, grains, meat, poultry, fish, and eggs.","PeriodicalId":93126,"journal":{"name":"Medical research and innovations","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67500506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yang Yang, O. Z. Olatunde, Jianping Yong, Canzhong Lu
Podocarpus nagi is a tree belonging to the family of Podocarpaceae, which has ever been used for treatment of trauma, stop-bleeding, fractures, knife wounds, gunshot wounds, body odor, eye diseases, colds and rheumatoid arthritis in clinic. Some compounds have been isolated and their biological activities were also evaluated. it’s seeds contains much oil and which can be used for food after refining or directly used industrially. In this work, the trace elements in the nuts, nut shell and oil residue were detected by the method of atomic absorption spectrum, which can provide reference for the further study. *Correspondence to: Jianping Yong, Xiamen Institute of Rare-earth Materials, Haixi Institute, Chinese Academy of Sciences, Xiamen, 361021, China, Tel: +86-591-63173162, E-mail: jpyong@fjirsm.ac.cn Canzhong Lu, Xiamen Institute of Rare-earth Materials, Haixi Institute, Chinese Academy of Sciences, Xiamen, 361021, China, Tel: +86-591-83705794, E-mail: czlu@fjirsm.ac.cn
{"title":"Quantitative analysis of trace elements in Podocarpus nagi seeds","authors":"Yang Yang, O. Z. Olatunde, Jianping Yong, Canzhong Lu","doi":"10.15761/MRI.1000151","DOIUrl":"https://doi.org/10.15761/MRI.1000151","url":null,"abstract":"Podocarpus nagi is a tree belonging to the family of Podocarpaceae, which has ever been used for treatment of trauma, stop-bleeding, fractures, knife wounds, gunshot wounds, body odor, eye diseases, colds and rheumatoid arthritis in clinic. Some compounds have been isolated and their biological activities were also evaluated. it’s seeds contains much oil and which can be used for food after refining or directly used industrially. In this work, the trace elements in the nuts, nut shell and oil residue were detected by the method of atomic absorption spectrum, which can provide reference for the further study. *Correspondence to: Jianping Yong, Xiamen Institute of Rare-earth Materials, Haixi Institute, Chinese Academy of Sciences, Xiamen, 361021, China, Tel: +86-591-63173162, E-mail: jpyong@fjirsm.ac.cn Canzhong Lu, Xiamen Institute of Rare-earth Materials, Haixi Institute, Chinese Academy of Sciences, Xiamen, 361021, China, Tel: +86-591-83705794, E-mail: czlu@fjirsm.ac.cn","PeriodicalId":93126,"journal":{"name":"Medical research and innovations","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44921201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hu Cong, Zheng Wei, Wang Wei, C. Lei, Zhong Jiwen, Z. Fan, Z. Ling
{"title":"Assessment the immune function of aged patients before and after immunotherapy in severe sepsis","authors":"Hu Cong, Zheng Wei, Wang Wei, C. Lei, Zhong Jiwen, Z. Fan, Z. Ling","doi":"10.15761/mri.1000157","DOIUrl":"https://doi.org/10.15761/mri.1000157","url":null,"abstract":"","PeriodicalId":93126,"journal":{"name":"Medical research and innovations","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67499654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yang Yang, Olagoke Zacchaeus Olatunde, Jianping Yong, Yuchen Xiao, Canzhong Lu
There are a lot of active components (amino acids, polysaccharides, saponins, alkaloids, flavonoids, organic acids and essential oils) and many trace elements in the leaves of A. sinensis . It has been reported that A. sinensis leaves were used as functional health tea. But till now, there is no report about the determination of the trance elements in the leaves of A. sinensis , we tested the trace elements in the leaves of A. sinensis using ICP-MS, to provide the valuable scientific evidence for the development of drinks .
{"title":"Determination the trace elements in Aquilaria sinensis leave By ICP-MS","authors":"Yang Yang, Olagoke Zacchaeus Olatunde, Jianping Yong, Yuchen Xiao, Canzhong Lu","doi":"10.15761/mri.1000163","DOIUrl":"https://doi.org/10.15761/mri.1000163","url":null,"abstract":"There are a lot of active components (amino acids, polysaccharides, saponins, alkaloids, flavonoids, organic acids and essential oils) and many trace elements in the leaves of A. sinensis . It has been reported that A. sinensis leaves were used as functional health tea. But till now, there is no report about the determination of the trance elements in the leaves of A. sinensis , we tested the trace elements in the leaves of A. sinensis using ICP-MS, to provide the valuable scientific evidence for the development of drinks .","PeriodicalId":93126,"journal":{"name":"Medical research and innovations","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67499913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparative studies on the roles of calcium ions and gap Junctions in the regulation of secretory and contractile processes: Biochemical and pharmacologic approaches","authors":"Viktor I Goudochnikov","doi":"10.15761/mri.1000153","DOIUrl":"https://doi.org/10.15761/mri.1000153","url":null,"abstract":"","PeriodicalId":93126,"journal":{"name":"Medical research and innovations","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67499568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This work points out importance of medical radioisotopes in nuclear medicine based on treatment and diagnosis of cancer. Moreover, possible production methods of medical radioisotopes are evaluated, and an application for the production of two medical radioisotopes through neutron and deuteron induced reaction processes is discussed by comparing with experimental data in the literature. *Correspondence to: Ozan Artun, Department of Physics, Zonguldak Bülent Ecevit University, Turkey, E-mail: ozanartun@beun.edu.tr / ozanartun@yahoo.com Received: March 12, 2019; Accepted: March 25, 2019; Published: March 28, 2019 Introduction Nuclear medicine plays an important role in diagnosis and treatment of cancerous cells using different devices some of which are Single Photon Emission Computed Tomography (SPECT), Positron Emission Tomography (PET), which are used in diagnostic aims [14]. Addition to diagnosis, cancer treatment is also available in nuclear medicine; however, the therapy can be separated two section as internal and external therapy. For instance, Intensity-modulated radiation therapy (IMRT) [5] that is a type of 3-D conformal radiation therapy [6] is an external therapy device. On the other hand, brachytherapy that is fairly important method can be called as internal therapy. In the literature, a lot of devices and methods to use medical radioisotopes in nuclear medicine are available in the literature. Common point of ones is definitely radioisotopes used in diagnosis and treatment of cancer, and these radioisotopes are produced by either nuclear reactors or particle accelerators via neutron reactions like (n,γ) or charged particle induced reaction processes e.g. proton, deuteron and alpha particles. Some of the famous radioisotopes produced in nuclear reactors may give Mo-99, P-32, Cu-64, Y-90 radioisotopes. Furthermore, medical radioisotopes produced by the charged particle induced reactions are commonly used in PET and SPECT. Such a production is carried out particle accelerators with energy ranges 1-50 MeV such as O-15, F-18, Ga-68 etc. But, for production of Ac-225 that is therapeutic purpose particle accelerators with higher energy are necessary [7]. Therefore, the production method of radioisotopes used in nuclear medicine can change kind of nuclei based on their half-lives and type of emission. For an application of the production of medical radioisotopes, we investigated the production of Kr-42 and Mn-51 radioisotopes via deuteron and neutron induced reaction processes. Materials and method The productions of K-42 and Mn-51 radioisotopes used for medical aims were carried out by neutron and deuteron induced reaction in energy region between 1 MeV and 30 MeV incident energy. Therefore, we used 45Sc(n,α)42K and 50Cr(d,n)51Mn reactions where the purities of the target materials are above 99% and each target is uniform [5,7,8]. The cross-section calculations were performed two component exciton models via TALYS 1.9 code [9] and the level
本文从癌症的治疗和诊断出发,指出了医用放射性同位素在核医学中的重要性。此外,对医用放射性同位素的可能生产方法进行了评价,并通过与文献实验数据的比较,讨论了利用中子和氘核诱导反应工艺生产两种医用放射性同位素的应用。*通讯作者:Ozan Artun,土耳其Zonguldak blent Ecevit大学物理系,E-mail: ozanartun@beun.edu.tr / ozanartun@yahoo.com录用日期:2019年3月25日;简介核医学在癌细胞的诊断和治疗中发挥着重要作用,使用不同的设备,其中一些是用于诊断目的的单光子发射计算机断层扫描(SPECT),正电子发射断层扫描(PET)。除了诊断之外,核医学还提供癌症治疗;然而,治疗可分为内外两部分。例如,调强放射治疗(IMRT)[5]是一种三维适形放射治疗[6]是一种外部治疗设备。另一方面,近距离治疗是一种相当重要的方法,可以称为内部治疗。在文献中,有很多在核医学中使用医用放射性同位素的装置和方法。它们的共同点肯定是用于癌症诊断和治疗的放射性同位素,这些放射性同位素由核反应堆或粒子加速器通过中子反应(n,γ)或带电粒子诱导反应过程(如质子,氘核和α粒子)产生。在核反应堆中产生的一些著名的放射性同位素可能产生Mo-99、P-32、Cu-64、Y-90等放射性同位素。此外,由带电粒子诱导反应产生的医用放射性同位素通常用于PET和SPECT。这种生产是在能量范围为1-50 MeV的粒子加速器上进行的,如O-15、F-18、Ga-68等。但是,为了生产用于治疗目的的Ac-225,需要更高能量的粒子加速器。因此,核医学中使用的放射性同位素的生产方法可以根据半衰期和发射类型来改变原子核的种类。为了医用放射性同位素生产的应用,我们研究了通过氘和中子诱导反应过程生产Kr-42和Mn-51放射性同位素。材料和方法在入射能量1 - 30 MeV之间的能量区,用中子和氘核诱导反应制备了医用放射性同位素K-42和Mn-51。因此,我们采用45Sc(n,α)42K和50Cr(d,n)51Mn反应,目标材料的纯度在99%以上,且各目标均匀[5,7,8]。横截面计算采用TALYS 1.9代码[9]进行双组分激子模型计算,能级密度模型选用恒温费米气体模型[1]。每个反应的计算结果与Exfor数据库[10]中的实验数据进行了比较。45Sc(n,α)42K和50Cr(d,n)51Mn反应的计算截面随入射能量的变化如图1和图2所示。在45Sc(n,α)42K反应中,Subasi et al.(1998)、Molla et al.(1998)、Doczi et al.(1998)、Bostan and Qaim(1994)、Grallert et al.(1993)、Belgaid et al.(1992)、Ikeda et al.(1988)、Levkovskii et al.(1969)、Bayhurst and Prestwood(1961)[11-19]测量了大量实验数据,显然计算截面与实验数据基本一致。特别是在中子入射能量14 MeV左右的最大截面值上,实验截面值高达70 MeV。此外,对于50Cr(d,n)51Mn反应,Klein等(2000)[20]报道的实验数据与从阈值到5 MeV的计算截面曲线吻合;但在5 MeV以上,实验数据高于理论截面曲线。另一方面,在5 MeV以内,实验值和理论值是一致的(图2)。结论本工作中,我们计算了中子和氘核诱导反应产生51Mn和42K放射性同位素,并将所得结果与文献数据中的实验数据进行了比较。计算数据与实验数据在确定入射能量的最大截面值上吻合较好。另外,为了产生51Mn放射性同位素,氘诱导反应在文献中没有足够的实验和理论结果。因此,我们可以为51Mn的生产提出新的实验和理论工作。 本文从癌症的治疗和诊断出发,指出了医用放射性同位素在核医学中的重要性。此外,对医用放射性同位素的可能生产方法进行了评价,并通过与文献实验数据的比较,讨论了利用中子和氘核诱导反应工艺生产两种医用放射性同位素的应用。*通讯作者:Ozan Artun,土耳其Zonguldak blent Ecevit大学物理系,E-mail: ozanartun@beun.edu.tr / ozanartun@yahoo.com录用日期:2019年3月25日;简介核医学在癌细胞的诊断和治疗中发挥着重要作用,使用不同的设备,其中一些是用于诊断目的的单光子发射计算机断层扫描(SPECT),正电子发射断层扫描(PET)。除了诊断之外,核医学还提供癌症治疗;然而,治疗可分为内外两部分。例如,调强放射治疗(IMRT)[5]是一种三维适形放射治疗[6]是一种外部治疗设备。另一方面,近距离治疗是一种相当重要的方法,可以称为内部治疗。在文献中,有很多在核医学中使用医用放射性同位素的装置和方法。它们的共同点肯定是用于癌症诊断和治疗的放射性同位素,这些放射性同位素由核反应堆或粒子加速器通过中子反应(n,γ)或带电粒子诱导反应过程(如质子,氘核和α粒子)产生。在核反应堆中产生的一些著名的放射性同位素可能产生Mo-99、P-32、Cu-64、Y-90等放射性同位素。此外,由带电粒子诱导反应产生的医用放射性同位素通常用于PET和SPECT。这种生产是在能量范围为1-50 MeV的粒子加速器上进行的,如O-15、F-18、Ga-68等。但是,为了生产用于治疗目的的Ac-225,需要更高能量的粒子加速器。因此,核医学中使用的放射性同位素的生产方法可以根据半衰期和发射类型来改变原子核的种类。为了医用放射性同位素生产的应用,我们研究了通过氘和中子诱导反应过程生产Kr-42和Mn-51放射性同位素。材料和方法在入射能量1 - 30 MeV之间的能量区,用中子和氘核诱导反应制备了医用放射性同位素K-42和Mn-51。因此,我们采用45Sc(n,α)42K和50Cr(d,n)51Mn反应,目标材料的纯度在99%以上,且各目标均匀[5,7,8]。横截面计算采用TALYS 1.9代码[9]进行双组分激子模型计算,能级密度模型选用恒温费米气体模型[1]。每个反应的计算结果与Exfor数据库[10]中的实验数据进行了比较。45Sc(n,α)42K和50Cr(d,n)51Mn反应的计算截面随入射能量的变化如图1和图2所示。在45Sc(n,α)42K反应中,Subasi et al.(1998)、Molla et al.(1998)、Doczi et al.(1998)、Bostan and Qaim(1994)、Grallert et al.(1993)、Belgaid et al.(1992)、Ikeda et al.(1988)、Levkovskii et al.(1969)、Bayhurst and Prestwood(1961)[11-19]测量了大量实验数据,显然计算截面与实验数据基本一致。特别是在中子入射能量14 MeV左右的最大截面值上,实验截面值高达70 MeV。此外,对于50Cr(d,n)51Mn反应,Klein等(2000)[20]报道的实验数据与从阈值到5 MeV的计算截面曲线吻合;但在5 Me
{"title":"An application and importance of production of medical radioisotopes used in cancer therapy and diagnosis","authors":"O. Artun","doi":"10.15761/MRI.1000155","DOIUrl":"https://doi.org/10.15761/MRI.1000155","url":null,"abstract":"This work points out importance of medical radioisotopes in nuclear medicine based on treatment and diagnosis of cancer. Moreover, possible production methods of medical radioisotopes are evaluated, and an application for the production of two medical radioisotopes through neutron and deuteron induced reaction processes is discussed by comparing with experimental data in the literature. *Correspondence to: Ozan Artun, Department of Physics, Zonguldak Bülent Ecevit University, Turkey, E-mail: ozanartun@beun.edu.tr / ozanartun@yahoo.com Received: March 12, 2019; Accepted: March 25, 2019; Published: March 28, 2019 Introduction Nuclear medicine plays an important role in diagnosis and treatment of cancerous cells using different devices some of which are Single Photon Emission Computed Tomography (SPECT), Positron Emission Tomography (PET), which are used in diagnostic aims [14]. Addition to diagnosis, cancer treatment is also available in nuclear medicine; however, the therapy can be separated two section as internal and external therapy. For instance, Intensity-modulated radiation therapy (IMRT) [5] that is a type of 3-D conformal radiation therapy [6] is an external therapy device. On the other hand, brachytherapy that is fairly important method can be called as internal therapy. In the literature, a lot of devices and methods to use medical radioisotopes in nuclear medicine are available in the literature. Common point of ones is definitely radioisotopes used in diagnosis and treatment of cancer, and these radioisotopes are produced by either nuclear reactors or particle accelerators via neutron reactions like (n,γ) or charged particle induced reaction processes e.g. proton, deuteron and alpha particles. Some of the famous radioisotopes produced in nuclear reactors may give Mo-99, P-32, Cu-64, Y-90 radioisotopes. Furthermore, medical radioisotopes produced by the charged particle induced reactions are commonly used in PET and SPECT. Such a production is carried out particle accelerators with energy ranges 1-50 MeV such as O-15, F-18, Ga-68 etc. But, for production of Ac-225 that is therapeutic purpose particle accelerators with higher energy are necessary [7]. Therefore, the production method of radioisotopes used in nuclear medicine can change kind of nuclei based on their half-lives and type of emission. For an application of the production of medical radioisotopes, we investigated the production of Kr-42 and Mn-51 radioisotopes via deuteron and neutron induced reaction processes. Materials and method The productions of K-42 and Mn-51 radioisotopes used for medical aims were carried out by neutron and deuteron induced reaction in energy region between 1 MeV and 30 MeV incident energy. Therefore, we used 45Sc(n,α)42K and 50Cr(d,n)51Mn reactions where the purities of the target materials are above 99% and each target is uniform [5,7,8]. The cross-section calculations were performed two component exciton models via TALYS 1.9 code [9] and the level","PeriodicalId":93126,"journal":{"name":"Medical research and innovations","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67499618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}