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Change in subjective well-being and the associated costs of a woman-targeted presbyopia correction programme among older craftswomen in Zanzibar: a cost-outcome and scenario analysis.
IF 4.1 2区 医学 Q1 OPHTHALMOLOGY Pub Date : 2025-01-29 DOI: 10.1136/bjo-2024-325887
Ving Fai Chan,Omar Juma Othman,Ai Chee Yong,Christine Graham,Carlos Price-Sanchez,Bhagyalaxmi Shivalingam Pillai,Eleanor Holland,Emma McConnell,Jamison Jones,Adrianna Farmer,Michelle Fernandes Martins,Kajal Shah,Damaris Mulewa,Ronnie Graham,Eden Mashayo,Fatma Omar
BACKGROUNDA pilot eyecare programme aimed to address the urgent eye health needs of older Zanzibari craftswomen. We investigated the impact of correcting presbyopia on their subjective well-being (SWB) 6 months post-correction and assessed the cost-effectiveness of a women-targeted presbyopia correction programme.METHODSThis study involved Zanzibari craftswomen aged 40 and older with presenting and corrected distance visual acuity better than 6/12 in both eyes and were presbyopic. Using a before-after method, we assessed SWB on a 10-point scale before and after providing free spectacles. Mean SWB scores and differences pre-correction and post-correction were calculated. Programme costs were analysed to determine the cost per SWB score gained and the monthly cost for each SWB score improvement. Additionally, scenario analysis estimated costs for 12 approaches.RESULTSOf 282 craftswomen, 209 met the eligibility criteria. SWB scores significantly increased from 3.34 to 8.14 post correction (p<0.001). Screening costs totalled US$12 885.84, with an average cost of US$45.69 per craftswoman screened and US$61.66 per presbyopia identification. The total programme cost was US$14,574.69. One hundred fifty-four craftswomen experienced increased SWB, with a total of 747 score gains. Achieving one SWB score improvement cost an average of US$19.50, with a monthly average cost of US$3.40 per improvement. Utilising woman screeners, organised transport and ready-made spectacles appeared to be the most cost-effective approach.CONCLUSIONCorrecting presbyopia through a targeted eyecare programme significantly enhanced SWB among craftswomen. While the programme seems cost-effective, further research is warranted to explore long-term economic benefits and definitively assess cost-effectiveness in larger studies.
{"title":"Change in subjective well-being and the associated costs of a woman-targeted presbyopia correction programme among older craftswomen in Zanzibar: a cost-outcome and scenario analysis.","authors":"Ving Fai Chan,Omar Juma Othman,Ai Chee Yong,Christine Graham,Carlos Price-Sanchez,Bhagyalaxmi Shivalingam Pillai,Eleanor Holland,Emma McConnell,Jamison Jones,Adrianna Farmer,Michelle Fernandes Martins,Kajal Shah,Damaris Mulewa,Ronnie Graham,Eden Mashayo,Fatma Omar","doi":"10.1136/bjo-2024-325887","DOIUrl":"https://doi.org/10.1136/bjo-2024-325887","url":null,"abstract":"BACKGROUNDA pilot eyecare programme aimed to address the urgent eye health needs of older Zanzibari craftswomen. We investigated the impact of correcting presbyopia on their subjective well-being (SWB) 6 months post-correction and assessed the cost-effectiveness of a women-targeted presbyopia correction programme.METHODSThis study involved Zanzibari craftswomen aged 40 and older with presenting and corrected distance visual acuity better than 6/12 in both eyes and were presbyopic. Using a before-after method, we assessed SWB on a 10-point scale before and after providing free spectacles. Mean SWB scores and differences pre-correction and post-correction were calculated. Programme costs were analysed to determine the cost per SWB score gained and the monthly cost for each SWB score improvement. Additionally, scenario analysis estimated costs for 12 approaches.RESULTSOf 282 craftswomen, 209 met the eligibility criteria. SWB scores significantly increased from 3.34 to 8.14 post correction (p<0.001). Screening costs totalled US$12 885.84, with an average cost of US$45.69 per craftswoman screened and US$61.66 per presbyopia identification. The total programme cost was US$14,574.69. One hundred fifty-four craftswomen experienced increased SWB, with a total of 747 score gains. Achieving one SWB score improvement cost an average of US$19.50, with a monthly average cost of US$3.40 per improvement. Utilising woman screeners, organised transport and ready-made spectacles appeared to be the most cost-effective approach.CONCLUSIONCorrecting presbyopia through a targeted eyecare programme significantly enhanced SWB among craftswomen. While the programme seems cost-effective, further research is warranted to explore long-term economic benefits and definitively assess cost-effectiveness in larger studies.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"13 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term visual outcomes and side effects of ruthenium plaque brachytherapy in 310 eyes with small choroidal melanoma.
IF 3.7 2区 医学 Q1 OPHTHALMOLOGY Pub Date : 2025-01-29 DOI: 10.1136/bjo-2023-324686
Beatrice Gallo, Rohan Hussain, Ranaa Al-Jamal, Hagar Khalid, Ian Stoker, Gordon Hay, Amit K Arora, Mandeep S Sagoo

Background/aims: To report the long-term visual outcomes and side effects in patients with small choroidal melanoma (CM) undergoing ruthenium-106 (Ru-106) plaque brachytherapy.

Methods: Retrospective, interventional, consecutive series of small CM ≤2.5 mm in height and ≤16 mm in largest basal diameter treated with Ru-106 plaque with a median radiation dose of 100 Gy prescribed to tumour apical height.

Results: 310 patients (160 men) with a mean (SD) age of 58.4±14.1 years met the study inclusion criteria. The median follow-up was 57.5 (range 3.4-170.5) months. The mean tumour baseline thickness was 1.9±0.4 (range 0.4-2.5) mm. The mean baseline logarithm of the minimum angle of resolution (logMAR) of best corrected visual acuity (BCVA) was 0.21±0.4 (Snellen equivalent 6/9; range -0.1 to 1.5). Mean final BCVA was ≤0.3 logMAR (Snellen equivalent 6/12) in 161 patients (54.2%), better than 1.0 logMAR (Snellen equivalent 6/60) and <0.3 logMAR in 59 patients (19.9%), and ≥1.0 logMAR in 77 patients (25.9%). Kaplan-Meier estimates of poor final VA (≥1.0 logMAR) were 13.2% at 5 years and 54.5% at 10 years. Early and late complications developed in 20.6% and 42.6% of cases, respectively. Radiation maculopathy was the most frequent late side effect (29% of patients) with Kaplan-Meier rates of 18.2%, 31.7% and 42.1% at 3, 5 and 10 years, respectively. Older age, lipofuscin, proximity to fovea, final tumour elevation and radiation maculopathy predicted visual loss ≥5 Snellen lines.

Conclusion: Despite early and late complications in 20.6% and 42.6% of cases, Ru-106 brachytherapy for small CM allows retention of BCVA ≤0.3 logMAR in half of the eyes.

{"title":"Long-term visual outcomes and side effects of ruthenium plaque brachytherapy in 310 eyes with small choroidal melanoma.","authors":"Beatrice Gallo, Rohan Hussain, Ranaa Al-Jamal, Hagar Khalid, Ian Stoker, Gordon Hay, Amit K Arora, Mandeep S Sagoo","doi":"10.1136/bjo-2023-324686","DOIUrl":"https://doi.org/10.1136/bjo-2023-324686","url":null,"abstract":"<p><strong>Background/aims: </strong>To report the long-term visual outcomes and side effects in patients with small choroidal melanoma (CM) undergoing ruthenium-106 (Ru-106) plaque brachytherapy.</p><p><strong>Methods: </strong>Retrospective, interventional, consecutive series of small CM ≤2.5 mm in height and ≤16 mm in largest basal diameter treated with Ru-106 plaque with a median radiation dose of 100 Gy prescribed to tumour apical height.</p><p><strong>Results: </strong>310 patients (160 men) with a mean (SD) age of 58.4±14.1 years met the study inclusion criteria. The median follow-up was 57.5 (range 3.4-170.5) months. The mean tumour baseline thickness was 1.9±0.4 (range 0.4-2.5) mm. The mean baseline logarithm of the minimum angle of resolution (logMAR) of best corrected visual acuity (BCVA) was 0.21±0.4 (Snellen equivalent 6/9; range -0.1 to 1.5). Mean final BCVA was ≤0.3 logMAR (Snellen equivalent 6/12) in 161 patients (54.2%), better than 1.0 logMAR (Snellen equivalent 6/60) and <0.3 logMAR in 59 patients (19.9%), and ≥1.0 logMAR in 77 patients (25.9%). Kaplan-Meier estimates of poor final VA (≥1.0 logMAR) were 13.2% at 5 years and 54.5% at 10 years. Early and late complications developed in 20.6% and 42.6% of cases, respectively. Radiation maculopathy was the most frequent late side effect (29% of patients) with Kaplan-Meier rates of 18.2%, 31.7% and 42.1% at 3, 5 and 10 years, respectively. Older age, lipofuscin, proximity to fovea, final tumour elevation and radiation maculopathy predicted visual loss ≥5 Snellen lines.</p><p><strong>Conclusion: </strong>Despite early and late complications in 20.6% and 42.6% of cases, Ru-106 brachytherapy for small CM allows retention of BCVA ≤0.3 logMAR in half of the eyes.</p>","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insights from 1096 clinical cases: pioneering a universal grading system for vernal keratoconjunctivitis management.
IF 4.1 2区 医学 Q1 OPHTHALMOLOGY Pub Date : 2025-01-29 DOI: 10.1136/bjo-2024-325762
Ambika Chandrasekar,Shweta Agarwal,Gaurav Chauhan,Bhaskar Srinivasan,Varsha Bhambani Chavda,Geetha Iyer
AIMTo analyse the clinical and demographic profiles of patients with vernal keratoconjunctivitis (VKC) and propose a grading for VKC based on corneal status and symptom periodicity rather than disease activity.METHODSRetrospective observational study from January 2015 to January 2020 in India. VKC grading was based on past/present clinical signs and frequency of symptoms rather than disease activity. The electronic medical records were screened and details of VKC patients diagnosed by cornea specialists were recorded and analysed.RESULTS1096 VKC patients with a mean age of onset of 7.05±5.3 with 8.39% having adult onset were analysed. Symptoms included; itching (50.55%) and decreased vision (15.44%). Mixed VKC (52.04%) was the most common presentation with 49.1% having active disease. Complications included; keratoconus (18.43%), steroid-induced cataract (11.41%), glaucoma (10.95%) and limbal stem cell deficiency (5.29%). Dual-acting antiallergics (69.39%) were most commonly used, followed by topical immunomodulators.The patients were graded as, grade I: mild-presence of mild and seasonal symptoms and/or signs. Grade II: moderate-presence of persistent symptoms/and/or signs without corneal involvement. Grade III: severe-chronic persistent symptoms/and/or intermittent signs with corneal involvement or asymptomatic to mild symptoms with corneal pathognomonic signs. Grade IV: very severe-chronic persistent symptoms and/or corneal pathognomonic signs or active involvement/complication or asymptomatic with complications.CONCLUSIONVKC is a chronic disease that often causes visual complications. The new grading system based on the cornea status and symptom periodicity rather than disease activity might help plan the management better.
{"title":"Insights from 1096 clinical cases: pioneering a universal grading system for vernal keratoconjunctivitis management.","authors":"Ambika Chandrasekar,Shweta Agarwal,Gaurav Chauhan,Bhaskar Srinivasan,Varsha Bhambani Chavda,Geetha Iyer","doi":"10.1136/bjo-2024-325762","DOIUrl":"https://doi.org/10.1136/bjo-2024-325762","url":null,"abstract":"AIMTo analyse the clinical and demographic profiles of patients with vernal keratoconjunctivitis (VKC) and propose a grading for VKC based on corneal status and symptom periodicity rather than disease activity.METHODSRetrospective observational study from January 2015 to January 2020 in India. VKC grading was based on past/present clinical signs and frequency of symptoms rather than disease activity. The electronic medical records were screened and details of VKC patients diagnosed by cornea specialists were recorded and analysed.RESULTS1096 VKC patients with a mean age of onset of 7.05±5.3 with 8.39% having adult onset were analysed. Symptoms included; itching (50.55%) and decreased vision (15.44%). Mixed VKC (52.04%) was the most common presentation with 49.1% having active disease. Complications included; keratoconus (18.43%), steroid-induced cataract (11.41%), glaucoma (10.95%) and limbal stem cell deficiency (5.29%). Dual-acting antiallergics (69.39%) were most commonly used, followed by topical immunomodulators.The patients were graded as, grade I: mild-presence of mild and seasonal symptoms and/or signs. Grade II: moderate-presence of persistent symptoms/and/or signs without corneal involvement. Grade III: severe-chronic persistent symptoms/and/or intermittent signs with corneal involvement or asymptomatic to mild symptoms with corneal pathognomonic signs. Grade IV: very severe-chronic persistent symptoms and/or corneal pathognomonic signs or active involvement/complication or asymptomatic with complications.CONCLUSIONVKC is a chronic disease that often causes visual complications. The new grading system based on the cornea status and symptom periodicity rather than disease activity might help plan the management better.","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":"53 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterisation of delayed severity flares in patients with HLA-B27-associated anterior uveitis. HLA-B27相关性前葡萄膜炎患者迟发性严重复发的特征。
IF 3.7 2区 医学 Q1 OPHTHALMOLOGY Pub Date : 2025-01-28 DOI: 10.1136/bjo-2024-325364
Andrew M Philip, Fatima Babiker, Carla C Fernandez-Santos, Max N Chikovsky, Andrew H Dolinko, Koosha Ramezani, Sydney Look-Why, Ambika Manhapra, Maria L Ruggeri, Peter Y Chang, Stephen Foster, Stephen D Anesi

Background/aims: To explore and characterise the clinical phenotype of acute anterior uveitis flares with delayed severity in patients with human leucocyte antigen B27 (HLA-B27)-associated anterior uveitis.

Methods: Retrospective chart review of patients with HLA-B27-associated anterior uveitis. Demographic and clinical data were recorded, as well as the clinical characteristics of acute anterior uveitis flares. A flare was considered to have delayed severity if any of the following criteria were met within 3-21 days of symptomatic onset: a two-step increase in anterior chamber inflammation on consecutive exams; a new development of hypopyon or fibrinoid aqueous reaction on consecutive examinations or a significant worsening of symptoms.

Results: A total of 371 patient charts were identified, of which 137 were included. 321 acute anterior uveitis flares were documented, with 36 (11.2%) meeting the criteria for a delayed severity flare. The average time from symptomatic onset was 10.2 days, and patients presented with an average anterior chamber cell grade of 3.5 in delayed severity flares compared with 1.6 in non-delayed severity flares. No significant difference in frequency of delayed severity presentation was noted based on the presence or absence of systemically associated rheumatological disease, papillitis on initial presentation and retinal vasculitis on initial presentation. The frequency of topical steroid therapy after symptomatic onset was not significantly different between the two flare phenotypes.

Conclusions: Our study presents the novel characterisation of a delayed severity phenotype of HLA-B27-associated acute anterior uveitis flares.

背景/目的探讨人类白细胞抗原B27(HLA-B27)相关性前葡萄膜炎患者急性前葡萄膜炎复发的临床表型及严重程度延迟的特征:方法:对HLA-B27相关前葡萄膜炎患者进行回顾性病历审查。记录人口统计学和临床数据,以及急性前葡萄膜炎发作的临床特征。如果在症状出现后3-21天内符合以下任何一项标准,则认为病情恶化延迟:连续检查时前房炎症增加两级;连续检查时出现新的视网膜下或纤维性水肿反应;或症状明显恶化:共发现371份病历,其中137份被纳入。记录了321例急性前葡萄膜炎复发,其中36例(11.2%)符合延迟严重性复发的标准。从症状出现到复发的平均时间为 10.2 天,延迟严重性复发患者的前房细胞平均等级为 3.5 级,而非延迟严重性复发患者的前房细胞平均等级为 1.6 级。根据患者是否患有系统性风湿病、初次发病时是否患有乳头状瘤炎以及初次发病时是否患有视网膜血管炎,延迟严重程度发作的频率没有明显差异。两种发作表型的患者在症状发作后接受局部类固醇治疗的频率没有显著差异:我们的研究揭示了 HLA-B27 相关急性前葡萄膜炎发作的延迟严重性表型的新特征。
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引用次数: 0
Expert CONsensus on Visual Evaluation in Retinal disease manaGEment: the CONVERGE study. 视网膜疾病管理中的视觉评估专家共识:CONVERGE 研究。
IF 3.7 2区 医学 Q1 OPHTHALMOLOGY Pub Date : 2025-01-28 DOI: 10.1136/bjo-2024-325310
Roger S Anderson, Mark Roark, Rose Gilbert, Dayyanah Sumodhee

Background/aims: Recent decades have seen significant advances in both structural and functional testing of retinal disease. However, the current clinical value of specific testing modalities, as well as future trends, need to be clearly identified in order to highlight areas for further development in routine care and clinical trials.

Methods: We designed a modified two-round Delphi study to obtain the opinion of a multidisciplinary group of 33 international experts involved in the field of retinal disease management/research to determine the level of agreement and consensus regarding the value and performance of specific structural and functional testing methods for retinal disease. On a Likert scale, a median of 1-2 indicated disagreement with the statement, and 5-6 indicated agreement with the statement. An IQR of ≤2 indicated consensus in the responses. Several questions also allowed comments on responses.

Results: There was overall agreement that structural testing currently predominates for detection and monitoring. There was moderate agreement that functional testing remains important and will continue to do so in the future because it provides complementary information. Certain respondents considered that properly designed and applied psychophysical tests are as reliable and repeatable as structural observations and that functional changes are the most important in the long run. Respondents considered future care and research to require a combination of structural and functional testing with strong consensus that the relative importance will depend on disease type and stage.

Conclusion: The study obtained important insights from a group of international experts regarding current and future needs in the management of retinal disease using a mix of quantitative and qualitative approaches. Responses provide a rich range of opinions that will be of interest to researchers seeking to design tests for future patient care and clinical trials.

背景/目的:近几十年来,视网膜疾病的结构和功能检测都取得了重大进展。然而,特定检测方式目前的临床价值以及未来的发展趋势需要明确确定,以便突出在常规护理和临床试验中进一步发展的领域:我们设计了一项经过修改的两轮德尔菲研究,以征求由 33 位视网膜疾病管理/研究领域的国际专家组成的多学科小组的意见,从而确定各方对视网膜疾病的特定结构和功能检测方法的价值和性能的一致意见和共识程度。采用李克特量表,中位数为 1-2 表示不同意该声明,5-6 表示同意该声明。IQR≤2表示答案一致。有几个问题还允许对回答进行评论:结果:总体上一致认为,目前结构性检测主要用于检测和监测。答复者基本同意功能测试仍然重要,并将在未来继续如此,因为它能提供补充信息。一些受访者认为,心理物理测试设计和应用得当,与结构观察一样可靠和可重复,从长远看,功能变化是最重要的。受访者认为,未来的护理和研究需要将结构和功能测试结合起来,并一致认为其相对重要性将取决于疾病的类型和阶段:这项研究采用定量和定性相结合的方法,从一组国际专家那里获得了关于视网膜疾病管理的当前和未来需求的重要见解。专家们的回答提供了丰富的意见,研究人员在设计用于未来患者护理和临床试验的检测项目时将会对这些意见感兴趣。
{"title":"Expert CONsensus on Visual Evaluation in Retinal disease manaGEment: the CONVERGE study.","authors":"Roger S Anderson, Mark Roark, Rose Gilbert, Dayyanah Sumodhee","doi":"10.1136/bjo-2024-325310","DOIUrl":"10.1136/bjo-2024-325310","url":null,"abstract":"<p><strong>Background/aims: </strong>Recent decades have seen significant advances in both structural and functional testing of retinal disease. However, the current clinical value of specific testing modalities, as well as future trends, need to be clearly identified in order to highlight areas for further development in routine care and clinical trials.</p><p><strong>Methods: </strong>We designed a modified two-round Delphi study to obtain the opinion of a multidisciplinary group of 33 international experts involved in the field of retinal disease management/research to determine the level of agreement and consensus regarding the value and performance of specific structural and functional testing methods for retinal disease. On a Likert scale, a median of 1-2 indicated disagreement with the statement, and 5-6 indicated agreement with the statement. An IQR of ≤2 indicated consensus in the responses. Several questions also allowed comments on responses.</p><p><strong>Results: </strong>There was overall agreement that structural testing currently predominates for detection and monitoring. There was moderate agreement that functional testing remains important and will continue to do so in the future because it provides complementary information. Certain respondents considered that properly designed and applied psychophysical tests are as reliable and repeatable as structural observations and that functional changes are the most important in the long run. Respondents considered future care and research to require a combination of structural and functional testing with strong consensus that the relative importance will depend on disease type and stage.</p><p><strong>Conclusion: </strong>The study obtained important insights from a group of international experts regarding current and future needs in the management of retinal disease using a mix of quantitative and qualitative approaches. Responses provide a rich range of opinions that will be of interest to researchers seeking to design tests for future patient care and clinical trials.</p>","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":" ","pages":"228-236"},"PeriodicalIF":3.7,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141859073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sympathetic ophthalmia: epidemiology and cohort-based assessment of clinical outcomes. 交感神经性眼炎:流行病学和基于队列的临床结果评估。
IF 3.7 2区 医学 Q1 OPHTHALMOLOGY Pub Date : 2025-01-28 DOI: 10.1136/bjo-2024-325267
Tim J Patterson, Weidong Gu, David Eliason, William Rojas-Carabali, Bernett Lee, Padmamalini Mahendradas, Jyotrimay Biswas, Parthopratim Dutta Majumder, Manisha Agarwal, Carlos Pavesio, Vishali Gupta, Rupesh Agrawal, Richard James Blanch

Background: The purpose of this study was to report the incidence, time after inciting event, aetiology and risk after specific intraocular procedures and the visual outcomes associated with sympathetic ophthalmia (SO) occurrence.

Methods: This study reports data from multiple retrospective cohorts: retrospective population-based data were extracted from the TRICARE service network (between 2017 and 2021) and retrospective case-based data from the Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) database (cohorts from the UK, South India and North India).

Results: There were 159 patients with SO identified. The length of time from sensitising event to SO occurrence was a median of 151 days (range: 6-9100 days).In the TRICARE database, 2 patients developed SO after open globe trauma and primary repair (of 615 eyes, rate 0.33%; 95% CI 1.26% to 1.30%). None developed SO after vitrectomy (total of 23 903 events; 95% CI 0% to 0.012%). The combined North Indian and UK cohorts reported 78.6% (81 patients) after trauma, 18.45% (19 patients) after elective surgery.Visual outcomes were reported in the OASIS database for 98.01% of patients (155 of 157 patients). The median presenting and final best corrected visual acuity (BCVA) for the inciting eye were no perception of light, the median presenting and final BCVA for the sympathising eye were 0.65 and 0.3 logMAR, respectively.

Conclusion: This study identified 159 cases of SO. With poor visual outcomes in the inciting eye, early diagnosis and management are crucial for optimising visual outcomes in the sympathising eye.

背景:本研究旨在报告特定眼内手术后的发病率、诱发事件后的时间、病因和风险,以及与交感神经性眼炎(SO)发生相关的视觉结果:本研究报告了多个回顾性队列的数据:从TRICARE服务网络(2017年至2021年)中提取了基于人群的回顾性数据,从眼部自身免疫系统炎症感染研究(OASIS)数据库(英国、南印度和北印度队列)中提取了基于病例的回顾性数据:结果:共发现 159 名 SO 患者。在 TRICARE 数据库中,有 2 名患者在开球创伤和初级修复后出现 SO(615 只眼睛中,发病率为 0.33%;95% CI 为 1.26% 至 1.30%)。玻璃体切除术后无一例发生 SO(共 23 903 例;95% CI 0% 至 0.012%)。据北印度和英国的联合队列报告,78.6%的患者(81例)在外伤后发生SO,18.45%的患者(19例)在择期手术后发生SO。OASIS数据库报告了98.01%的患者(157例患者中的155例)的视觉结果。诱发眼的初次和最终最佳矫正视力(BCVA)中位数均为无光感,同情眼的初次和最终BCVA中位数分别为0.65和0.3 logMAR:本研究发现了 159 例 SO。由于诱发眼的视觉效果不佳,早期诊断和治疗对于优化交感眼的视觉效果至关重要。
{"title":"Sympathetic ophthalmia: epidemiology and cohort-based assessment of clinical outcomes.","authors":"Tim J Patterson, Weidong Gu, David Eliason, William Rojas-Carabali, Bernett Lee, Padmamalini Mahendradas, Jyotrimay Biswas, Parthopratim Dutta Majumder, Manisha Agarwal, Carlos Pavesio, Vishali Gupta, Rupesh Agrawal, Richard James Blanch","doi":"10.1136/bjo-2024-325267","DOIUrl":"10.1136/bjo-2024-325267","url":null,"abstract":"<p><strong>Background: </strong>The purpose of this study was to report the incidence, time after inciting event, aetiology and risk after specific intraocular procedures and the visual outcomes associated with sympathetic ophthalmia (SO) occurrence.</p><p><strong>Methods: </strong>This study reports data from multiple retrospective cohorts: retrospective population-based data were extracted from the TRICARE service network (between 2017 and 2021) and retrospective case-based data from the Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) database (cohorts from the UK, South India and North India).</p><p><strong>Results: </strong>There were 159 patients with SO identified. The length of time from sensitising event to SO occurrence was a median of 151 days (range: 6-9100 days).In the TRICARE database, 2 patients developed SO after open globe trauma and primary repair (of 615 eyes, rate 0.33%; 95% CI 1.26% to 1.30%). None developed SO after vitrectomy (total of 23 903 events; 95% CI 0% to 0.012%). The combined North Indian and UK cohorts reported 78.6% (81 patients) after trauma, 18.45% (19 patients) after elective surgery.Visual outcomes were reported in the OASIS database for 98.01% of patients (155 of 157 patients). The median presenting and final best corrected visual acuity (BCVA) for the inciting eye were no perception of light, the median presenting and final BCVA for the sympathising eye were 0.65 and 0.3 logMAR, respectively.</p><p><strong>Conclusion: </strong>This study identified 159 cases of SO. With poor visual outcomes in the inciting eye, early diagnosis and management are crucial for optimising visual outcomes in the sympathising eye.</p>","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":" ","pages":"223-227"},"PeriodicalIF":3.7,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between long-term statin use and cataract surgery: a nationwide study on 505 105 cataract surgery patients. 长期服用他汀类药物与白内障手术之间的关系:一项针对 505 105 名白内障手术患者的全国性研究。
IF 3.7 2区 医学 Q1 OPHTHALMOLOGY Pub Date : 2025-01-28 DOI: 10.1136/bjo-2022-322409
Andrim Halili, Saranda Haxha, Bochra Zareini, Casper Lund-Andersen, Kathrine Kold Sørensen, Christian Torp-Pedersen, Talip E Eroglu, Casper Niels Bang

Aims: To assess the association between statin use and cataract surgery according to different statin treatment durations in patients with different cardiovascular risk profiles.

Methods and results: We performed a nested case-control study using Danish registries, covering the period from 1 January 1996 to 31 December 2020. We defined cases as surgically treated cataract patients, matched in a 1:1 ratio by sex and age with controls not undergoing cataract surgery. The exposure of interest was statin use in different durations (1, 5 and 10 years) compared with never use of statins. Conditional logistic regression provided adjusted HRs and corresponding 95% CIs in subgroups defined by established atherosclerotic cardiovascular disease, diabetes, hypertension and individuals without these comorbidities. We identified 505 150 cataract surgery cases and found no increased HR of cataract surgery with statin treatment at any duration in any of the subgroups with established atherosclerotic cardiovascular disease, diabetes or hypertension.

Conclusion: Our findings do not support a possible association between long-term statin use and cataract in patients with established atherosclerotic cardiovascular disease, diabetes or hypertension. Although we found an association between statin use and cataract in individuals without these comorbidities, increasing durations of statin use did not yield higher cataract surgery rates.

目的:根据他汀类药物治疗的不同持续时间,评估不同心血管风险状况的患者使用他汀类药物与白内障手术之间的关联:我们利用丹麦登记资料开展了一项巢式病例对照研究,研究时间跨度为 1996 年 1 月 1 日至 2020 年 12 月 31 日。我们将病例定义为接受过手术治疗的白内障患者,按性别和年龄与未接受白内障手术的对照组以 1:1 的比例进行配对。与从未使用过他汀类药物相比,不同持续时间(1 年、5 年和 10 年)的他汀类药物使用才是我们关注的暴露因素。条件逻辑回归提供了根据已确诊的动脉粥样硬化性心血管疾病、糖尿病、高血压和无这些合并症的个体所定义的亚组的调整 HRs 和相应的 95% CI。我们确定了 505 150 例白内障手术病例,发现在任何时间段内,他汀类药物治疗都不会增加已患动脉粥样硬化性心血管疾病、糖尿病或高血压的亚组的白内障手术HR:我们的研究结果不支持长期服用他汀类药物与已确诊的动脉粥样硬化性心血管疾病、糖尿病或高血压患者的白内障之间可能存在的关联。尽管我们发现他汀类药物的使用与没有这些合并症的白内障患者之间存在关联,但他汀类药物使用时间的延长并不会导致白内障手术率的升高。
{"title":"Association between long-term statin use and cataract surgery: a nationwide study on 505 105 cataract surgery patients.","authors":"Andrim Halili, Saranda Haxha, Bochra Zareini, Casper Lund-Andersen, Kathrine Kold Sørensen, Christian Torp-Pedersen, Talip E Eroglu, Casper Niels Bang","doi":"10.1136/bjo-2022-322409","DOIUrl":"10.1136/bjo-2022-322409","url":null,"abstract":"<p><strong>Aims: </strong>To assess the association between statin use and cataract surgery according to different statin treatment durations in patients with different cardiovascular risk profiles.</p><p><strong>Methods and results: </strong>We performed a nested case-control study using Danish registries, covering the period from 1 January 1996 to 31 December 2020. We defined cases as surgically treated cataract patients, matched in a 1:1 ratio by sex and age with controls not undergoing cataract surgery. The exposure of interest was statin use in different durations (1, 5 and 10 years) compared with never use of statins. Conditional logistic regression provided adjusted HRs and corresponding 95% CIs in subgroups defined by established atherosclerotic cardiovascular disease, diabetes, hypertension and individuals without these comorbidities. We identified 505 150 cataract surgery cases and found no increased HR of cataract surgery with statin treatment at any duration in any of the subgroups with established atherosclerotic cardiovascular disease, diabetes or hypertension.</p><p><strong>Conclusion: </strong>Our findings do not support a possible association between long-term statin use and cataract in patients with established atherosclerotic cardiovascular disease, diabetes or hypertension. Although we found an association between statin use and cataract in individuals without these comorbidities, increasing durations of statin use did not yield higher cataract surgery rates.</p>","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":" ","pages":"192-198"},"PeriodicalIF":3.7,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141757236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Choroidal involvement in acute retinal necrosis: case series and review of the literature. 急性视网膜坏死的脉络膜受累:病例系列和文献综述。
IF 3.7 2区 医学 Q1 OPHTHALMOLOGY Pub Date : 2025-01-28 DOI: 10.1136/bjo-2024-325724
Anamika Patel, Avinash Pathengay, Carlos Pavesio, Ilaria Testi

Purpose: To show the role of multimodal imaging in identifying choroidal involvement in acute retinal necrosis (ARN).

Methods: Retrospective case series of ARN patients. Clinical data, including medical history, clinical features and multimodal imaging findings, were collected.

Results: Three patients were included. Imaging modalities, such as indocyanine green angiography and optical coherence tomography, were critical in showing choroidal involvement in ARN.

Conclusion: Choroidal involvement may occur in ARN along with the well-known retinal features.

目的:显示多模态成像在识别急性视网膜坏死(ARN)脉络膜受累方面的作用:方法:急性视网膜坏死患者的回顾性病例系列。收集临床数据,包括病史、临床特征和多模态成像结果:结果:共纳入三名患者。吲哚菁绿血管造影术和光学相干断层扫描等成像模式对显示 ARN 患者脉络膜受累至关重要:结论:脉络膜受累可能与众所周知的视网膜特征同时出现在 ARN 中。
{"title":"Choroidal involvement in acute retinal necrosis: case series and review of the literature.","authors":"Anamika Patel, Avinash Pathengay, Carlos Pavesio, Ilaria Testi","doi":"10.1136/bjo-2024-325724","DOIUrl":"10.1136/bjo-2024-325724","url":null,"abstract":"<p><strong>Purpose: </strong>To show the role of multimodal imaging in identifying choroidal involvement in acute retinal necrosis (ARN).</p><p><strong>Methods: </strong>Retrospective case series of ARN patients. Clinical data, including medical history, clinical features and multimodal imaging findings, were collected.</p><p><strong>Results: </strong>Three patients were included. Imaging modalities, such as indocyanine green angiography and optical coherence tomography, were critical in showing choroidal involvement in ARN.</p><p><strong>Conclusion: </strong>Choroidal involvement may occur in ARN along with the well-known retinal features.</p>","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":" ","pages":"203-208"},"PeriodicalIF":3.7,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141854895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predicting visual outcomes in keratoprosthesis surgery with critical flicker fusion frequency, B-scan, visual electrophysiology and endoscopy. 利用临界闪烁融合频率、B-扫描、视觉电生理学和内窥镜检查预测角膜移植手术的视觉效果。
IF 3.7 2区 医学 Q1 OPHTHALMOLOGY Pub Date : 2025-01-28 DOI: 10.1136/bjo-2024-325719
Guangcan Xu, Haolan Qi, Qianwei He, Mingxiong Chen, Junxia Fu, Qun Wang, Biyue Chen, Qing Hua Yang, Yifei Huang, Shihui Wei, Liqiang Wang

Purpose: This study evaluates the predictive power of the critical flicker fusion frequency (CFF) test for visual outcomes in keratoprosthesis (KPro) candidates, comparing its accuracy with B-scan ultrasound, flash visual evoked potentials (fVEP) and endoscopy.

Methods: The study included 42 patients (42 eyes) scheduled for KPro surgery with a median follow-up period of 6 months. The receiver operating characteristic curve identified the cut-off threshold for CFF in the model development study (17 eyes). All patients in the comparison study (25 eyes) underwent preoperative assessments including trichromatic CFF (red, green and yellow), B-scan ultrasound, fVEP and perioperative endoscopy. Results were classified as either favourable or unfavourable predictors of visual outcomes based on predefined criteria. Sensitivity and specificity of each assessment were calculated based on postoperative best-corrected visual acuity (BCVA)≥20/200. The Bland-Altman test assessed the consistency between CFF-predicted BCVA and actual BCVA.

Results: Among the trichromatic CFF tests, the yellow-CFF (yCFF) exhibited the highest area under the curve value of 0.97 and a cut-off threshold at 10 Hz for predicting postoperative BCVA≥20/200 (p<0.05). yCFF achieved 90% sensitivity and 80% specificity in predicting satisfactory postoperative outcomes. Endoscopy had 80% sensitivity and 80% specificity, B-scan showed 70% sensitivity and 60% specificity, and fVEP had 75% sensitivity and 40% specificity. yCFF showed a mean bias of 0.091 logarithm of the minimum angle of resolution (logMAR) in postoperative prediction.

Conclusions: The CFF test provides robust visual function evaluation in KPro candidates. It demonstrates superior predictive accuracy for visual prognosis compared with routine ophthalmologic examinations, such as B-scan ultrasonography, fVEP and endoscopy.

目的:本研究评估了临界闪烁融合频率(CFF)测试对角膜前列腺成形术(KPro)候选者视觉结果的预测能力,并将其准确性与B扫描超声波、闪光视觉诱发电位(fVEP)和内窥镜检查进行了比较:研究包括 42 名计划接受 KPro 手术的患者(42 只眼),中位随访时间为 6 个月。在模型开发研究(17 眼)中,接收器操作特征曲线确定了 CFF 的临界值。对比研究中的所有患者(25 眼)都接受了术前评估,包括三基色 CFF(红、绿、黄)、B 扫描超声波、fVEP 和围手术期内窥镜检查。根据预先确定的标准,评估结果被归类为对视觉结果有利或不利的预测因素。根据术后最佳矫正视力(BCVA)≥20/200计算每项评估的敏感性和特异性。Bland-Altman检验评估了CFF预测的BCVA与实际BCVA之间的一致性:结果:在三基色 CFF 测试中,黄色 CFF(yCFF)的曲线下面积值最高,为 0.97,预测术后 BCVA≥20/200 的临界值为 10 Hz(p 结论:CFF 测试提供了可靠的视觉功能:CFF 测试为 KPro 候选者提供了可靠的视觉功能评估。与 B-scan 超声波检查、fVEP 和内窥镜检查等常规眼科检查相比,它对视觉预后的预测准确性更高。
{"title":"Predicting visual outcomes in keratoprosthesis surgery with critical flicker fusion frequency, B-scan, visual electrophysiology and endoscopy.","authors":"Guangcan Xu, Haolan Qi, Qianwei He, Mingxiong Chen, Junxia Fu, Qun Wang, Biyue Chen, Qing Hua Yang, Yifei Huang, Shihui Wei, Liqiang Wang","doi":"10.1136/bjo-2024-325719","DOIUrl":"10.1136/bjo-2024-325719","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluates the predictive power of the critical flicker fusion frequency (CFF) test for visual outcomes in keratoprosthesis (KPro) candidates, comparing its accuracy with B-scan ultrasound, flash visual evoked potentials (fVEP) and endoscopy.</p><p><strong>Methods: </strong>The study included 42 patients (42 eyes) scheduled for KPro surgery with a median follow-up period of 6 months. The receiver operating characteristic curve identified the cut-off threshold for CFF in the model development study (17 eyes). All patients in the comparison study (25 eyes) underwent preoperative assessments including trichromatic CFF (red, green and yellow), B-scan ultrasound, fVEP and perioperative endoscopy. Results were classified as either favourable or unfavourable predictors of visual outcomes based on predefined criteria. Sensitivity and specificity of each assessment were calculated based on postoperative best-corrected visual acuity (BCVA)≥20/200. The Bland-Altman test assessed the consistency between CFF-predicted BCVA and actual BCVA.</p><p><strong>Results: </strong>Among the trichromatic CFF tests, the yellow-CFF (yCFF) exhibited the highest area under the curve value of 0.97 and a cut-off threshold at 10 Hz for predicting postoperative BCVA≥20/200 (p<0.05). yCFF achieved 90% sensitivity and 80% specificity in predicting satisfactory postoperative outcomes. Endoscopy had 80% sensitivity and 80% specificity, B-scan showed 70% sensitivity and 60% specificity, and fVEP had 75% sensitivity and 40% specificity. yCFF showed a mean bias of 0.091 logarithm of the minimum angle of resolution (logMAR) in postoperative prediction.</p><p><strong>Conclusions: </strong>The CFF test provides robust visual function evaluation in KPro candidates. It demonstrates superior predictive accuracy for visual prognosis compared with routine ophthalmologic examinations, such as B-scan ultrasonography, fVEP and endoscopy.</p>","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":" ","pages":"177-184"},"PeriodicalIF":3.7,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141995394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterising the refractive error in paediatric patients with congenital stationary night blindness: a multicentre study. 先天性静止性夜盲症儿科患者屈光不正的特征:一项多中心研究。
IF 3.7 2区 医学 Q1 OPHTHALMOLOGY Pub Date : 2025-01-28 DOI: 10.1136/bjo-2023-323747
Austin D Igelman, Elizabeth White, Alaa Tayyib, Lesley Everett, Ajoy Vincent, Elise Heon, Christina Zeitz, Michel Michaelides, Omar A Mahroo, Mohamed Katta, Andrew Webster, Markus Preising, Birgit Lorenz, Samer Khateb, Eyal Banin, Dror Sharon, Shahar Luski, Filip Van Den Broeck, Bart Peter Leroy, Elfride De Baere, Sophie Walraedt, Katarina Stingl, Laura Kuehlewein, Susanne Kohl, Milda Reith, Anne Fulton, Aparna Raghuram, Isabelle Meunier, Hélène Dollfus, Tomas S Aleman, Emma C Bedoukian, Erin C O'Neil, Emily Krauss, Andrea Vincent, Charlotte Jordan, Alessandro Iannaccone, Parveen Sen, Srilekha Sundaramurthy, Soumittra Nagasamy, Irina Balikova, Ingele Casteels, Shyamanga Borooah, Shaden Yassin, Aaron Nagiel, Hillary Schwartz, Xavier Zanlonghi, Irene Gottlob, Rebecca J McLean, Francis L Munier, Andrew Stephenson, Robert Sisk, Robert Koenekoop, Lorri B Wilson, Douglas Fredrick, Dongseok Choi, Paul Yang, Mark Edward Pennesi

Background/aaims: Congenital stationary night blindness (CSNB) is an inherited retinal disease that is often associated with high myopia and can be caused by pathological variants in multiple genes, most commonly CACNA1F, NYX and TRPM1. High myopia is associated with retinal degeneration and increased risk for retinal detachment. Slowing the progression of myopia in patients with CSNB would likely be beneficial in reducing risk, but before interventions can be considered, it is important to understand the natural history of myopic progression.

Methods: This multicentre, retrospective study explored CSNB caused by variants in CACNA1F, NYX or TRPM1 in patients who had at least 6 measurements of their spherical equivalent of refraction (SER) before the age of 18. A mixed-effect model was used to predict progression of SER overtime and differences between genotypes were evaluated.

Results: 78 individuals were included in this study. All genotypes showed a significant myopic predicted SER at birth (-3.076D, -5.511D and -5.386D) for CACNA1F, NYX and TRPM1 respectively. Additionally, significant progression of myopia per year (-0.254D, -0.257D and -0.326D) was observed for all three genotypes CACNA1F, NYX and TRPM1, respectively.

Conclusions: Patients with CSNB tend to be myopic from an early age and progress to become more myopic with age. Patients may benefit from long-term myopia slowing treatment in the future and further studies are indicated. Additionally, CSNB should be considered in the differential diagnosis for early-onset myopia.

背景/目的:先天性静止性夜盲(CSNB)是一种遗传性视网膜疾病,通常与高度近视有关,可由多个基因(最常见的是 CACNA1F、NYX 和 TRPM1)的病理变异引起。高度近视与视网膜变性和视网膜脱离风险增加有关。减缓 CSNB 患者的近视进展可能有利于降低风险,但在考虑干预措施之前,了解近视进展的自然史非常重要:这项多中心回顾性研究探讨了由 CACNA1F、NYX 或 TRPM1 变异引起的 CSNB,研究对象是 18 岁前至少测量过 6 次球面等效屈光度(SER)的患者。研究采用混合效应模型预测 SER 随时间推移的进展情况,并评估不同基因型之间的差异:本研究共纳入 78 人。所有基因型的 CACNA1F、NYX 和 TRPM1 在出生时的预测 SER 都显示出明显的近视(分别为-3.076D、-5.511D 和-5.386D)。此外,在所有三种基因型 CACNA1F、NYX 和 TRPM1 中,每年都观察到近视度数明显加深(-0.254D、-0.257D 和 -0.326D):结论:CSNB 患者往往自幼近视,并随着年龄的增长近视度数加深。结论:CSNB 患者从幼年开始就有近视倾向,并随着年龄的增长近视度数加深。此外,在早期近视的鉴别诊断中应考虑 CSNB。
{"title":"Characterising the refractive error in paediatric patients with congenital stationary night blindness: a multicentre study.","authors":"Austin D Igelman, Elizabeth White, Alaa Tayyib, Lesley Everett, Ajoy Vincent, Elise Heon, Christina Zeitz, Michel Michaelides, Omar A Mahroo, Mohamed Katta, Andrew Webster, Markus Preising, Birgit Lorenz, Samer Khateb, Eyal Banin, Dror Sharon, Shahar Luski, Filip Van Den Broeck, Bart Peter Leroy, Elfride De Baere, Sophie Walraedt, Katarina Stingl, Laura Kuehlewein, Susanne Kohl, Milda Reith, Anne Fulton, Aparna Raghuram, Isabelle Meunier, Hélène Dollfus, Tomas S Aleman, Emma C Bedoukian, Erin C O'Neil, Emily Krauss, Andrea Vincent, Charlotte Jordan, Alessandro Iannaccone, Parveen Sen, Srilekha Sundaramurthy, Soumittra Nagasamy, Irina Balikova, Ingele Casteels, Shyamanga Borooah, Shaden Yassin, Aaron Nagiel, Hillary Schwartz, Xavier Zanlonghi, Irene Gottlob, Rebecca J McLean, Francis L Munier, Andrew Stephenson, Robert Sisk, Robert Koenekoop, Lorri B Wilson, Douglas Fredrick, Dongseok Choi, Paul Yang, Mark Edward Pennesi","doi":"10.1136/bjo-2023-323747","DOIUrl":"10.1136/bjo-2023-323747","url":null,"abstract":"<p><strong>Background/aaims: </strong>Congenital stationary night blindness (CSNB) is an inherited retinal disease that is often associated with high myopia and can be caused by pathological variants in multiple genes, most commonly <i>CACNA1F</i>, <i>NYX</i> and <i>TRPM1</i>. High myopia is associated with retinal degeneration and increased risk for retinal detachment. Slowing the progression of myopia in patients with CSNB would likely be beneficial in reducing risk, but before interventions can be considered, it is important to understand the natural history of myopic progression.</p><p><strong>Methods: </strong>This multicentre, retrospective study explored CSNB caused by variants in <i>CACNA1F</i>, <i>NYX</i> or <i>TRPM1</i> in patients who had at least 6 measurements of their spherical equivalent of refraction (SER) before the age of 18. A mixed-effect model was used to predict progression of SER overtime and differences between genotypes were evaluated.</p><p><strong>Results: </strong>78 individuals were included in this study. All genotypes showed a significant myopic predicted SER at birth (-3.076D, -5.511D and -5.386D) for <i>CACNA1F</i>, <i>NYX</i> and <i>TRPM1</i> respectively. Additionally, significant progression of myopia per year (-0.254D, -0.257D and -0.326D) was observed for all three genotypes <i>CACNA1F</i>, <i>NYX</i> and <i>TRPM1</i>, respectively.</p><p><strong>Conclusions: </strong>Patients with CSNB tend to be myopic from an early age and progress to become more myopic with age. Patients may benefit from long-term myopia slowing treatment in the future and further studies are indicated. Additionally, CSNB should be considered in the differential diagnosis for early-onset myopia.</p>","PeriodicalId":9313,"journal":{"name":"British Journal of Ophthalmology","volume":" ","pages":"286-292"},"PeriodicalIF":3.7,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11774682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141854894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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British Journal of Ophthalmology
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