Praveen Kumar Moturi, Venkata Krishna Gollapalli, Sri Sabya Karanam
Objective: Local-anaesthetic (LA)-induced myotoxicity in the use of peripheral nerve blocks has emerged as a topic of interest recently. Very few studies on human subjects have been done in this field, though the technique of nerve blocks is being widely practiced both for anaesthesia and analgesia. Studies have shown that bupivacaine induces reproducible skeletal muscle degeneration. The present study is thus aimed at comparing the myotoxicity induced by bupivacaine and ropivacaine in interfascial plane blocks.Material and Methods: The study was a randomized comparative study done at a tertiary care hospital. The subjects were randomly assigned into 3 groups of 50 patients each:- Group B, with patients in whom bupivacaine was used; Group R, comprised of patients in which ropivacaine was used, Group N, who received no fascial plane block during their procedures. An erector spinae block (ESP block) was performed for patients undergoing unilateral lung decortication or lobectomy. Creatine phosphokinase (CPK) levels at 6 and 24 hours after completion of surgery were taken in all 3 groups and compared with baseline values using Repeated Measures Analysis of Variance.Results: Baseline serum CPK levels were similar in all 3 study groups. Significant increases in serum CPK levels were noticed in group B compared to group R at 6 hours and 24 hours, with no increase in group N.Conclusion: The study showed that serum CPK, a marker of skeletal muscle injury and local-anaesthetic-induced myotoxicity, significantly rose at 24 hours after an ESP block and this increase was considerably higher in group B (bupivacaine) compared to group R (ropivacaine), indicating significantly higher myotoxicity with bupivacaine.
{"title":"Local-Anaesthetic-Induced Myotoxicity in Interfascial Plane Blocks: A Comparative Study between Bupivacaine and Ropivacaine","authors":"Praveen Kumar Moturi, Venkata Krishna Gollapalli, Sri Sabya Karanam","doi":"10.31584/jhsmr.2023992","DOIUrl":"https://doi.org/10.31584/jhsmr.2023992","url":null,"abstract":"Objective: Local-anaesthetic (LA)-induced myotoxicity in the use of peripheral nerve blocks has emerged as a topic of interest recently. Very few studies on human subjects have been done in this field, though the technique of nerve blocks is being widely practiced both for anaesthesia and analgesia. Studies have shown that bupivacaine induces reproducible skeletal muscle degeneration. The present study is thus aimed at comparing the myotoxicity induced by bupivacaine and ropivacaine in interfascial plane blocks.Material and Methods: The study was a randomized comparative study done at a tertiary care hospital. The subjects were randomly assigned into 3 groups of 50 patients each:- Group B, with patients in whom bupivacaine was used; Group R, comprised of patients in which ropivacaine was used, Group N, who received no fascial plane block during their procedures. An erector spinae block (ESP block) was performed for patients undergoing unilateral lung decortication or lobectomy. Creatine phosphokinase (CPK) levels at 6 and 24 hours after completion of surgery were taken in all 3 groups and compared with baseline values using Repeated Measures Analysis of Variance.Results: Baseline serum CPK levels were similar in all 3 study groups. Significant increases in serum CPK levels were noticed in group B compared to group R at 6 hours and 24 hours, with no increase in group N.Conclusion: The study showed that serum CPK, a marker of skeletal muscle injury and local-anaesthetic-induced myotoxicity, significantly rose at 24 hours after an ESP block and this increase was considerably higher in group B (bupivacaine) compared to group R (ropivacaine), indicating significantly higher myotoxicity with bupivacaine.","PeriodicalId":93205,"journal":{"name":"Journal of Health Science and Medical Research (JHSMR)","volume":"140 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135536681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: This study aimed to assess the respiratory muscle strength in stable chronic obstructive pulmonary disease (COPD) patients, via measuring maximal respiratory mouth pressures [maximal inspiratory pressure (PImax) and maximal expiratory pressure (PEmax)] to determine its association with disease severity and quality of life.Material and Methods: The study was a cross-sectional comparative study. A hundred and forty subjects (70 COPD patients and 70 controls) were recruited. Measurements of PImax, PEmax and spirometry were then performed. The health-related quality of life, severity of obstruction and dyspnea in the COPD patients were assessed using the COPD Assessment Test (CAT), post-bronchodilator Forced Expiratory Volume in 1 second (FEV 1) and the modified Medical Research Council (mMRC) dyspnea scale, respectively. Data was analyzed using Statistical Package for the Social Science (SPSS) version 25.0 (SPSS IL USA.).Results: The mean (±S.D.) PImax and PEmax of the COPD patients (31.78±14.40 cmH2O and 54.80±18.89 cmH2O, respectively) were significantly lower (p<0.001) than the controls (80.40±7.50 cmH2O and 95.44±12.52 cmH2O, respectively). Both the PImax and PEmax correlated positively with the FEV1 of the COPD patients (r=0.658 and 0.534, respectively, p<0.001). The PImax and PEmax decreased as the mMRC dyspnea grade worsened (p<0.001). There was a negative correlation between PImax; PEmax and the CAT score of the COPD patients (r=-0.704 and–0.583, respectively, p<0.001).Conclusion: There was significant respiratory muscle weakness in the COPD patients compared with the controls. The respiratory muscle weakness worsened as the airflow obstruction and dyspnea worsened. Respiratory muscle weakness may also add to the negative impact COPD has on the health status of COPD patients.
{"title":"Maximal Respiratory Mouth Pressures Assessment in Stable Chronic Obstructive Pulmonary Disease Patients in a Tertiary Hospital in Southwest Nigeria","authors":"Oluwafunmilayo Oguntoye, Gregory Erhabor, Olufemi Adewole, Olayemi Awopeju, Bolanle Adefuye, Eruke Egbagbe, Temitope Kolawole, Oluwatosin Oguntoye, Abidemi Fasae, Paul Olowoyo, Azeez Ibrahim, Adenike Arawomo, Oluwatosin Jeeged, Olumuyiwa Ariyo","doi":"10.31584/jhsmr.2023993","DOIUrl":"https://doi.org/10.31584/jhsmr.2023993","url":null,"abstract":"Objective: This study aimed to assess the respiratory muscle strength in stable chronic obstructive pulmonary disease (COPD) patients, via measuring maximal respiratory mouth pressures [maximal inspiratory pressure (PImax) and maximal expiratory pressure (PEmax)] to determine its association with disease severity and quality of life.Material and Methods: The study was a cross-sectional comparative study. A hundred and forty subjects (70 COPD patients and 70 controls) were recruited. Measurements of PImax, PEmax and spirometry were then performed. The health-related quality of life, severity of obstruction and dyspnea in the COPD patients were assessed using the COPD Assessment Test (CAT), post-bronchodilator Forced Expiratory Volume in 1 second (FEV 1) and the modified Medical Research Council (mMRC) dyspnea scale, respectively. Data was analyzed using Statistical Package for the Social Science (SPSS) version 25.0 (SPSS IL USA.).Results: The mean (±S.D.) PImax and PEmax of the COPD patients (31.78±14.40 cmH2O and 54.80±18.89 cmH2O, respectively) were significantly lower (p<0.001) than the controls (80.40±7.50 cmH2O and 95.44±12.52 cmH2O, respectively). Both the PImax and PEmax correlated positively with the FEV1 of the COPD patients (r=0.658 and 0.534, respectively, p<0.001). The PImax and PEmax decreased as the mMRC dyspnea grade worsened (p<0.001). There was a negative correlation between PImax; PEmax and the CAT score of the COPD patients (r=-0.704 and–0.583, respectively, p<0.001).Conclusion: There was significant respiratory muscle weakness in the COPD patients compared with the controls. The respiratory muscle weakness worsened as the airflow obstruction and dyspnea worsened. Respiratory muscle weakness may also add to the negative impact COPD has on the health status of COPD patients.","PeriodicalId":93205,"journal":{"name":"Journal of Health Science and Medical Research (JHSMR)","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135536825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The purpose of this study was to investigate adverse events related to kratom cessation and the utilization of prescribed medications during hospitalization.Material and Methods: This retrospective study was conducted in Thanyarak Songkhla Hospital, Thailand. The study included patients aged 15 years and above who had a history of kratom consumption prior to hospitalization. Adverse events after kratom discontinuation during the patient’s hospital admission were documented. The prescribed drug regimens during hospitalization were recorded.Results: During the 4-year study period, 81 patients were enrolled. Fifty-four patients (67%) developed adverse events. The majority of enrolled patients were males between the ages of 15 and 34 years. The popular 4x100 kratom cocktail was commonly consumed prior to admission. Musculoskeletal pain (28%) and psychological disorders such as insomnia, agitation, and anxiety were observed as major adverse events. Patients with adverse events received more medications than those without adverse events (p-value=0.02). Typical antipsychotics were commonly prescribed for patients with adverse events related to kratom discontinuation (p-value<0.01).Conclusion: In hospitalized patients who had consumed kratom previously, 67% experienced adverse events. The most common adverse events were musculoskeletal pain and psychological disorders. In patients with adverse events, antipsychotics were commonly prescribed. A history of kratom consumption should be asked during hospitalization for all admitted patients to assess the possibility of an adverse event and provide appropriate management.
{"title":"Adverse Events Related to Kratom Discontinuation and the Utilization of Prescribed Medications During Hospitalization: A 4-year Retrospective Study in Thanyarak Songkhla Hospital, Thailand","authors":"Sirima Sitaruno, Juraithip Wungsintaweekul, Tanatape Wanishayakorn, Tharin Kanjanasintou, Nattrawee Srisai, Chanocknun Kongruen, Chawisa Chaimongkon, Saodaro Sodadis, Thanurat Putthachat","doi":"10.31584/jhsmr.2023991","DOIUrl":"https://doi.org/10.31584/jhsmr.2023991","url":null,"abstract":"Objective: The purpose of this study was to investigate adverse events related to kratom cessation and the utilization of prescribed medications during hospitalization.Material and Methods: This retrospective study was conducted in Thanyarak Songkhla Hospital, Thailand. The study included patients aged 15 years and above who had a history of kratom consumption prior to hospitalization. Adverse events after kratom discontinuation during the patient’s hospital admission were documented. The prescribed drug regimens during hospitalization were recorded.Results: During the 4-year study period, 81 patients were enrolled. Fifty-four patients (67%) developed adverse events. The majority of enrolled patients were males between the ages of 15 and 34 years. The popular 4x100 kratom cocktail was commonly consumed prior to admission. Musculoskeletal pain (28%) and psychological disorders such as insomnia, agitation, and anxiety were observed as major adverse events. Patients with adverse events received more medications than those without adverse events (p-value=0.02). Typical antipsychotics were commonly prescribed for patients with adverse events related to kratom discontinuation (p-value<0.01).Conclusion: In hospitalized patients who had consumed kratom previously, 67% experienced adverse events. The most common adverse events were musculoskeletal pain and psychological disorders. In patients with adverse events, antipsychotics were commonly prescribed. A history of kratom consumption should be asked during hospitalization for all admitted patients to assess the possibility of an adverse event and provide appropriate management.","PeriodicalId":93205,"journal":{"name":"Journal of Health Science and Medical Research (JHSMR)","volume":"80 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136155248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The characteristics of adipose-derived stem cells (ADSC), isolated from buccal fat pads when cultured in media supplemented, with either autologous human serum (AHS group) or fetal bovine serum (FBS group) were compared.Material and Methods: Buccal fat tissue was harvested from six patients, who had undergone surgical removal of their maxillary third molars or underwent orthognathic surgeries. ADSC were isolated from the tissue, via an enzymatic digestion method and cultured in the media of the AHS and FBS groups (n=6/group). Colony forming units-fibroblast (CFU-F), immune-phenotyping markers, growth and multi-differentiation of the cells from both groups were compared.Results:The number of CFU-F and the cell growth of the AHS group were significantly greater than those of the FBS group (p-value<0.05). The expressions of the mesenchymal and hematopoietic stem cell markers of both groups were not statistically different. The cells of both groups had the potential for adipogenesis, chondrogenesis and osteogenesis when cultured in inductive conditions.Conclusion: The immunophenotype and multi-differentiation of ADSC, which were cultured in AHS- and FBS- media, were not different. However, the AHS medium could support the capacity for forming colonies and growth of the cells better than the FBS medium.
{"title":"Characteristics of Buccal Fat Adipose-Derived Stem Cells Cultured in Autologous Human Serum- and Fetal Bovine Serum-Supplemented Media: A Comparative Study","authors":"Lalita Charoenmuang, Nuttawut Thuaksuban, Woraporn Supphaprasitt, Narit Leepong, Danaiya Supakanjanakanti, Surapong Vongvatcharanon","doi":"10.31584/jhsmr.2023988","DOIUrl":"https://doi.org/10.31584/jhsmr.2023988","url":null,"abstract":"Objective: The characteristics of adipose-derived stem cells (ADSC), isolated from buccal fat pads when cultured in media supplemented, with either autologous human serum (AHS group) or fetal bovine serum (FBS group) were compared.Material and Methods: Buccal fat tissue was harvested from six patients, who had undergone surgical removal of their maxillary third molars or underwent orthognathic surgeries. ADSC were isolated from the tissue, via an enzymatic digestion method and cultured in the media of the AHS and FBS groups (n=6/group). Colony forming units-fibroblast (CFU-F), immune-phenotyping markers, growth and multi-differentiation of the cells from both groups were compared.Results:The number of CFU-F and the cell growth of the AHS group were significantly greater than those of the FBS group (p-value<0.05). The expressions of the mesenchymal and hematopoietic stem cell markers of both groups were not statistically different. The cells of both groups had the potential for adipogenesis, chondrogenesis and osteogenesis when cultured in inductive conditions.Conclusion: The immunophenotype and multi-differentiation of ADSC, which were cultured in AHS- and FBS- media, were not different. However, the AHS medium could support the capacity for forming colonies and growth of the cells better than the FBS medium.","PeriodicalId":93205,"journal":{"name":"Journal of Health Science and Medical Research (JHSMR)","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135110023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reviewer Acknowledgement, 2023","authors":"Surasak Sangkhathat","doi":"10.31584/jhsmr.2023990","DOIUrl":"https://doi.org/10.31584/jhsmr.2023990","url":null,"abstract":"-","PeriodicalId":93205,"journal":{"name":"Journal of Health Science and Medical Research (JHSMR)","volume":"121 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135203343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Adlay has been reported to prevent osteoporosis, and promote osteoblast cell proliferation and in vitro calcification. However, it has never been used on modified titanium (Ti) surfaces. Hence, the aim of this study was to ameliorate Ti surfaces, by coating with adlay seed extract via the polyelectrolyte multilayer (PEM) film technique. Material and Methods: Adlay seed extract solution containing 150, 300, 600, or 1500 μg/ml concentrations was coated on Ti discs using a layer-by-layer technique to fabricate PEM films (Ti_Adlay surface). The surface characterizations; including atomic force microscope analysis, contact angle analysis and energy dispersive X-ray analysis were evaluated. The osteoblast cell proliferation on its modified surface was also examined. Results: Adlay seed extract could increase surface irregularity, roughness, hydrophilicity and carbon composition of Ti surface in all Ti_Adlay groups. At 24, 48 and 72 hours of incubation, the osteoblast cells morphology was similar in all groups. At 24 hours, the viable cell numbers on all Ti_Adlay groups were statistically lower than the uncoated Ti group, while no significant difference was found after 48 and 72 hours of incubation. Conclusion: Adlay PEM coating on Ti surface could improve the surface properties of Ti in terms of surface roughness, hydrophilicity and surface chemistry. Even though Ti-Adlay surfaces showed no toxic effect on MC3T3-E1, it was unlikely
{"title":"Adlay Polyelectrolyte Multilayer Films Coated on Titanium: Surface Characteristics and MC3T3-E1 Cell Morphology and Proliferation","authors":"Atthasit Boonbanyen, Onauma Angwaravong, Kavita Kanjanamekanant, Thidarat Angwarawong","doi":"10.31584/jhsmr.2023987","DOIUrl":"https://doi.org/10.31584/jhsmr.2023987","url":null,"abstract":"Objective: Adlay has been reported to prevent osteoporosis, and promote osteoblast cell proliferation and in vitro calcification. However, it has never been used on modified titanium (Ti) surfaces. Hence, the aim of this study was to ameliorate Ti surfaces, by coating with adlay seed extract via the polyelectrolyte multilayer (PEM) film technique. Material and Methods: Adlay seed extract solution containing 150, 300, 600, or 1500 μg/ml concentrations was coated on Ti discs using a layer-by-layer technique to fabricate PEM films (Ti_Adlay surface). The surface characterizations; including atomic force microscope analysis, contact angle analysis and energy dispersive X-ray analysis were evaluated. The osteoblast cell proliferation on its modified surface was also examined. Results: Adlay seed extract could increase surface irregularity, roughness, hydrophilicity and carbon composition of Ti surface in all Ti_Adlay groups. At 24, 48 and 72 hours of incubation, the osteoblast cells morphology was similar in all groups. At 24 hours, the viable cell numbers on all Ti_Adlay groups were statistically lower than the uncoated Ti group, while no significant difference was found after 48 and 72 hours of incubation. Conclusion: Adlay PEM coating on Ti surface could improve the surface properties of Ti in terms of surface roughness, hydrophilicity and surface chemistry. Even though Ti-Adlay surfaces showed no toxic effect on MC3T3-E1, it was unlikely","PeriodicalId":93205,"journal":{"name":"Journal of Health Science and Medical Research (JHSMR)","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135436995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: A phenylbutenoid extract (PE) was obtained from Zingiber cassumunar rhizomes. Phenylbutenoids; namely DMPBD, compound D, and compound D acetate, have been identified as major anti-inflammatory and analgesic constituents. This present study aimed to formulate a gel containing PE that could be used as an alternative ultrasound gel for acute or chronic inflammatory treatment. Material and Methods: Gel formulations containing 0.5, 1, and 2% w/w PE were prepared using Carbopol 934 and hydroxyethylcellulose (HEC 4,000) as gelling agents. The contents of phenylbutenoids were quantified by a high-performance liquid chromatography (HPLC). PE gels were studied on physicochemical properties and accelerated stability tests. The PE gels, F2 and F5, were used to evaluate the release of phenylbutenoids using a modified Franz diffusion cell. In the skin permeation study, the 2% PE gels were applied either with or without a 0.8 W/cm2 intensity ultrasound for 2, 5, and 10 min. Results: Based on physicochemical properties and accelerated stability tests, F2 and F5 formulations showed good stability. The release kinetics of 0.5% and 1% and 2% w/w PE of both formulations were best fit to Higuchi’s model and zero-order model, respectively. In the skin permeation study, PE gel combined with ultrasound application for 2 min exhibited higher phenylbutenoids in the skin and also a shorter lag time than PE gel application alone. Conclusion: The gel containing 2% w/w phenylbutenoid extract was suggested as an alternative ultrasound gel containing an anti-inflammatory agent for the treatment of musculoskeletal disorders in phonophoresis.
{"title":"Formulation of Gel Containing Phenylbutenoid Extract for Pain Relief","authors":"Thidaporn Gundom, Thanaporn Amnuaikit, Pharkphoom Panichayupakaranant","doi":"10.31584/jhsmr.2023986","DOIUrl":"https://doi.org/10.31584/jhsmr.2023986","url":null,"abstract":"Objective: A phenylbutenoid extract (PE) was obtained from Zingiber cassumunar rhizomes. Phenylbutenoids; namely DMPBD, compound D, and compound D acetate, have been identified as major anti-inflammatory and analgesic constituents. This present study aimed to formulate a gel containing PE that could be used as an alternative ultrasound gel for acute or chronic inflammatory treatment. Material and Methods: Gel formulations containing 0.5, 1, and 2% w/w PE were prepared using Carbopol 934 and hydroxyethylcellulose (HEC 4,000) as gelling agents. The contents of phenylbutenoids were quantified by a high-performance liquid chromatography (HPLC). PE gels were studied on physicochemical properties and accelerated stability tests. The PE gels, F2 and F5, were used to evaluate the release of phenylbutenoids using a modified Franz diffusion cell. In the skin permeation study, the 2% PE gels were applied either with or without a 0.8 W/cm2 intensity ultrasound for 2, 5, and 10 min. Results: Based on physicochemical properties and accelerated stability tests, F2 and F5 formulations showed good stability. The release kinetics of 0.5% and 1% and 2% w/w PE of both formulations were best fit to Higuchi’s model and zero-order model, respectively. In the skin permeation study, PE gel combined with ultrasound application for 2 min exhibited higher phenylbutenoids in the skin and also a shorter lag time than PE gel application alone. Conclusion: The gel containing 2% w/w phenylbutenoid extract was suggested as an alternative ultrasound gel containing an anti-inflammatory agent for the treatment of musculoskeletal disorders in phonophoresis.","PeriodicalId":93205,"journal":{"name":"Journal of Health Science and Medical Research (JHSMR)","volume":"145 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134912656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To adapt cross-culturally and examine the reliability and validity of the Thai version of MOXFQ (Thai-MOXFQ) among individuals with chronic foot pain. Material and Methods: The Thai-MOXFQ was successfully adapted cross-culturally from the original version with minor changes according to the International Society for Pharmacoeconomics and Outcomes Research (ISPOR) guidelines. Its reliability and construct validity were then investigated in individuals with chronic foot pain. The test-retest reliability was evaluated among 30 participants by calculating the intraclass correlation coefficient (ICC 3,1). Meanwhile, the internal consistency of the Thai-MOXFQ was studied in 100 participants by computing Cronbach’s alpha. Additionally, the construct validity was analyzed via Spearman’s rank correlation analysis to determine the relationship between the Thai-MOXFQ, Foot and Ankle Ability Measure (FAAM), 36-item Short-Form Health Survey (SF-36), and Visual Analogue Scale (VAS). Results: The Thai-MOXFQ demonstrated a good level of test-retest reliability (ICC of 0.763 to 0.885) and an acceptable level of internal consistency (Cronbach’s alpha of 0.738 to 0.871) when used in individuals with chronic foot pain. Moreover, the Thai-MOXFQ was shown to have moderate to strong relationships with FAAM, SF-36, and VAS (p-value<0.05, Spearman rank correlation coefficients of 0.543 to 0.711). Furthermore, the results of the construct validity of the Thai version were in line with the original English and other translated versions. Conclusion: The Thai-MOXFQ is a reliable and valid, foot-specific, patient-reported outcome measurement (PROM) for assessing outcomes in individuals with chronic foot pain.
{"title":"Cross-Cultural Adaptation, Reliability, and Validity Tests of the Thai Version of the Manchester-Oxford Foot Questionnaire in Individuals with Chronic Foot Pain","authors":"Poramut Kul-eung, Praneet Pensri","doi":"10.31584/jhsmr.2023972","DOIUrl":"https://doi.org/10.31584/jhsmr.2023972","url":null,"abstract":"Objective: To adapt cross-culturally and examine the reliability and validity of the Thai version of MOXFQ (Thai-MOXFQ) among individuals with chronic foot pain. Material and Methods: The Thai-MOXFQ was successfully adapted cross-culturally from the original version with minor changes according to the International Society for Pharmacoeconomics and Outcomes Research (ISPOR) guidelines. Its reliability and construct validity were then investigated in individuals with chronic foot pain. The test-retest reliability was evaluated among 30 participants by calculating the intraclass correlation coefficient (ICC 3,1). Meanwhile, the internal consistency of the Thai-MOXFQ was studied in 100 participants by computing Cronbach’s alpha. Additionally, the construct validity was analyzed via Spearman’s rank correlation analysis to determine the relationship between the Thai-MOXFQ, Foot and Ankle Ability Measure (FAAM), 36-item Short-Form Health Survey (SF-36), and Visual Analogue Scale (VAS). Results: The Thai-MOXFQ demonstrated a good level of test-retest reliability (ICC of 0.763 to 0.885) and an acceptable level of internal consistency (Cronbach’s alpha of 0.738 to 0.871) when used in individuals with chronic foot pain. Moreover, the Thai-MOXFQ was shown to have moderate to strong relationships with FAAM, SF-36, and VAS (p-value<0.05, Spearman rank correlation coefficients of 0.543 to 0.711). Furthermore, the results of the construct validity of the Thai version were in line with the original English and other translated versions. Conclusion: The Thai-MOXFQ is a reliable and valid, foot-specific, patient-reported outcome measurement (PROM) for assessing outcomes in individuals with chronic foot pain.","PeriodicalId":93205,"journal":{"name":"Journal of Health Science and Medical Research (JHSMR)","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136327658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jaray Tongtoyai, Nongkran Tatakham, Thitima Cherdtrakulkiat, Pachara Sirivongrangson, Andrew Hickey
Although Neisseria meningitidis (N. meningitidis) urogenital infections have been reported widely, meningococcal urethritis has not been reported previously in Thailand. A 42-year-old Thai male presented at a sexual health clinic with dysuria and urethral discharge following oral and insertive anal intercourse. N. meningitidis, serogroup C was cultured from a urethral discharge specimen and the patient was treated successfully with standard treatment for gonococcal urethritis. This case reflects a growing trend of reports describing meningococcal urethritis, likely resulting from sexual contact.
{"title":"<i>Neisseria Meningitidis</i> Urethritis in a Thai Male.","authors":"Jaray Tongtoyai, Nongkran Tatakham, Thitima Cherdtrakulkiat, Pachara Sirivongrangson, Andrew Hickey","doi":"10.31584/jhsmr.2020773","DOIUrl":"https://doi.org/10.31584/jhsmr.2020773","url":null,"abstract":"<p><p>Although <i>Neisseria meningitidis</i> (<i>N. meningitidis</i>) urogenital infections have been reported widely, meningococcal urethritis has not been reported previously in Thailand. A 42-year-old Thai male presented at a sexual health clinic with dysuria and urethral discharge following oral and insertive anal intercourse. <i>N. meningitidis</i>, serogroup C was cultured from a urethral discharge specimen and the patient was treated successfully with standard treatment for gonococcal urethritis. This case reflects a growing trend of reports describing meningococcal urethritis, likely resulting from sexual contact.</p>","PeriodicalId":93205,"journal":{"name":"Journal of Health Science and Medical Research (JHSMR)","volume":"39 3","pages":"251-255"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064693/pdf/nihms-1675100.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38908309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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