Pub Date : 2023-10-20DOI: 10.29011/2577-1515.100237
Septic thrombophlebitis is a condition characterized by venous thrombosis, inflammation, and bacteremia or fungemia [1]. Several distinct clinical conditions have been identified, depending on the vessel involved. Septic phlebitis of the deep venous system is a rare, but life-threatening emergency that may fail to respond to even the most aggressive therapy. Renal vein septic thrombophlebitis is a very rare disease and carries a high mortality rate. Here we report a case admitted as community acquired pneumonia and found to have picture of septic emboli in the lungs and imaging showed acute pyelonephritis and renal vein thrombosis in which she responded to treatment and recovered fully with antibiotics and anticoagulation.
{"title":"A Case of Septic Renal Vein Thrombophlebitis Secondary to Pyelonephritis Responded to Medical Treatment","authors":"","doi":"10.29011/2577-1515.100237","DOIUrl":"https://doi.org/10.29011/2577-1515.100237","url":null,"abstract":"Septic thrombophlebitis is a condition characterized by venous thrombosis, inflammation, and bacteremia or fungemia [1]. Several distinct clinical conditions have been identified, depending on the vessel involved. Septic phlebitis of the deep venous system is a rare, but life-threatening emergency that may fail to respond to even the most aggressive therapy. Renal vein septic thrombophlebitis is a very rare disease and carries a high mortality rate. Here we report a case admitted as community acquired pneumonia and found to have picture of septic emboli in the lungs and imaging showed acute pyelonephritis and renal vein thrombosis in which she responded to treatment and recovered fully with antibiotics and anticoagulation.","PeriodicalId":93299,"journal":{"name":"Infectious diseases diagnosis & treatment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135665348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-28DOI: 10.29011/2577-1515.100235
Background: Urinary tract Infection (UTI) is a significant global health burden, with high morbidity and mortality especially in developing nations. This study assessed the changing pattern of anti-microbial resistance (AMR) in UTI in secondary care centres of central India. Methodology: This was a prospective observational study conducted in 10 secondary care centres in smaller cities of Central India in the state of Madhya Pradesh. Result: Among the 8856 number of symptomatic urinary tract infections whose urine was sent for microbiological culture and sensitivity, 2409 (27.2%) showed significant pathological growth out of which 92.1% (2221/2409) showed bacterial growth and 7.8% (188/2409) showed fungal growth. Gram-negative bacteria accounted for 85.0% (1890/2221) and Gram-positive bacteria for 14.9% (331/2221). E. coli was the most prevalent Gram-negative isolate (57.4%), followed by K. pneumoniae (21.3%), Pseudomonas aeruginosa (12.1%). Third generation cephalosporin resistance was observed in 76.2% in E. coli and 71.6% in K. pneumonia . Carbapenem resistance was highest in P. aeruginosa (61.8%) followed by Acinetobacter spp (52.2%), Enterobacter spp. (50%) , K. pneumoniae (35.4%) and E. coli (22.6%). Colistin resistance was observed in Enterobacter spp. (15.0%) followed by Acinetobacter spp (9.1%), K. pneumoniae (7.6%), E. Coli (6.9%) and P. aeruginosa (4.9%). Among the gram-positive isolates, 47.5% of Staphylococcus aureus were Methicillin resistant and 3.7% were resistance to vancomycin. Among the Enterococcus spp. 14.1% were resistance to vancomycin. Conclusion: It is of great concern, that 20% of Escherichia coli and Klebsiella pneumonia islates are resistant to carbpenems in community settings at smaller cities in India. Though negligible, UTI caused by VRSA and VRE cannot be neglected. There is definitely a rise the occurrence of UTI caused by Candida .
{"title":"Antimicrobial Resistance Trends in Urinary Tract Infection at Secondary Care Centres in Central India: Carbepenem Resistance Crossing 20% in Community","authors":"","doi":"10.29011/2577-1515.100235","DOIUrl":"https://doi.org/10.29011/2577-1515.100235","url":null,"abstract":"Background: Urinary tract Infection (UTI) is a significant global health burden, with high morbidity and mortality especially in developing nations. This study assessed the changing pattern of anti-microbial resistance (AMR) in UTI in secondary care centres of central India. Methodology: This was a prospective observational study conducted in 10 secondary care centres in smaller cities of Central India in the state of Madhya Pradesh. Result: Among the 8856 number of symptomatic urinary tract infections whose urine was sent for microbiological culture and sensitivity, 2409 (27.2%) showed significant pathological growth out of which 92.1% (2221/2409) showed bacterial growth and 7.8% (188/2409) showed fungal growth. Gram-negative bacteria accounted for 85.0% (1890/2221) and Gram-positive bacteria for 14.9% (331/2221). E. coli was the most prevalent Gram-negative isolate (57.4%), followed by K. pneumoniae (21.3%), Pseudomonas aeruginosa (12.1%). Third generation cephalosporin resistance was observed in 76.2% in E. coli and 71.6% in K. pneumonia . Carbapenem resistance was highest in P. aeruginosa (61.8%) followed by Acinetobacter spp (52.2%), Enterobacter spp. (50%) , K. pneumoniae (35.4%) and E. coli (22.6%). Colistin resistance was observed in Enterobacter spp. (15.0%) followed by Acinetobacter spp (9.1%), K. pneumoniae (7.6%), E. Coli (6.9%) and P. aeruginosa (4.9%). Among the gram-positive isolates, 47.5% of Staphylococcus aureus were Methicillin resistant and 3.7% were resistance to vancomycin. Among the Enterococcus spp. 14.1% were resistance to vancomycin. Conclusion: It is of great concern, that 20% of Escherichia coli and Klebsiella pneumonia islates are resistant to carbpenems in community settings at smaller cities in India. Though negligible, UTI caused by VRSA and VRE cannot be neglected. There is definitely a rise the occurrence of UTI caused by Candida .","PeriodicalId":93299,"journal":{"name":"Infectious diseases diagnosis & treatment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135470282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-26DOI: 10.29011/2577-1515.100234
Introduction: Antimicrobial resistance (AMR) is a global health crisis. Urinary tract Infection (UTI) are one of the most commonly encountered infections and its management is becoming increasingly difficult in view of AMR. The present study was conducted to determine the epidemiology of causative agents and their susceptibility antibiogram. Methods: The study was a prospective longitudinal study of UTI patients from 2020 to 2021 at AIIMS Bhopal, India. Patients presenting to outpatient department (OPD) or hospitalized to low priority area (LPA) like general ward or high priority area (HPA) like Intensive Care Unit (ICU) or High Dependency Unit (HDU) with symptoms of UTI and whose urine sample was sent for microbiological culture sensitivity test were included in the study. Urine samples were collected and processed in the department of microbiology using standard protocols. Antimicrobial susceptibility test was carried out using the Kirby-Bauer disc diffusion method as per the Clinical Laboratory Standards Institute (CLSI) guidelines on Muller Hinton agar. Samples growing more than two organisms were discarded as contaminant. Urine samples were collected and analyzed using standard protocols. Results: Out of 14526 patients of symptomatic UTI cases (58.0% from OPD, 35.9% from LPA and 6.0% from HPA), whose urine sample was sent for microbiological culture sensitivity test, 2222 (15.2%) showed positive growth. Among the 2222 number of positive growth, 1510 (67.9%) were community acquired, 186 (8.3%) was Health care Associated UTI and 526 (23.6%) cases could not be differentiated into either group. Among 1510 community acquired UTI cases, Gram Negative Bacilli (GNB) were identified in 88.7%, Gram Positive Cocci (GPC) in 10.1% and Candida in 1.0% cases. Among 1510 community acquired UTI cases, E. coli were identified in 58.9%, K. pneumonia in 15.4%, Enterococcus in 8.5% and P. aeruginosa in 4.2% cases. Among the E. coli isolates 3rd generation cephalosporin resistance was identified in 84% in OPD vs. 92% in LPA vs. 100% in HPA, fluroquinolone resisatnce was in 82% in OPD vs. 94% in LPA vs. 1000% in HPA, piperacillin resistance in 38% in OPD vs. 63% in LPA vs. 67% in HPA, carbapenem resistance in 13% in OPD vs. 40% in LPA vs. 47% in HPA. Among the K. pneumoniae isolates 3rd generation cephalosporin resistance was identified in 78% in OPD vs. 91% in LPA vs. 100% in HPA, fluroquinolone resisatnce was in 64% in OPD vs. 86% in LPA vs. 80% in HPA, piperacillin resistance in 53% in OPD vs. 75% in LPA vs. 56% in HPA, carbapenem resistance in 14% in OPD vs. 67% in LPA vs. 55% in HPA. Among the Enterococcus isolates, vancomycin resistance was observed in 21% in OPD Vs. 24% in hospitalized cases. Conclusion: E. coli and K. pneumoniae together accounted for about two third microbiologically confirmed cases. Carbapenem resistance of about 10% in OPD cases and 50% in hospitalized patients seems alarming. Customized Anti microbial stewardship program (AMSP) at each
{"title":"Changing Patterns of Antimicrobial Susceptibility of Uro-pathogens in Community-acquired Urinary Tract Infections in Central India: Two Year Prospective Surveillance Report","authors":"","doi":"10.29011/2577-1515.100234","DOIUrl":"https://doi.org/10.29011/2577-1515.100234","url":null,"abstract":"Introduction: Antimicrobial resistance (AMR) is a global health crisis. Urinary tract Infection (UTI) are one of the most commonly encountered infections and its management is becoming increasingly difficult in view of AMR. The present study was conducted to determine the epidemiology of causative agents and their susceptibility antibiogram. Methods: The study was a prospective longitudinal study of UTI patients from 2020 to 2021 at AIIMS Bhopal, India. Patients presenting to outpatient department (OPD) or hospitalized to low priority area (LPA) like general ward or high priority area (HPA) like Intensive Care Unit (ICU) or High Dependency Unit (HDU) with symptoms of UTI and whose urine sample was sent for microbiological culture sensitivity test were included in the study. Urine samples were collected and processed in the department of microbiology using standard protocols. Antimicrobial susceptibility test was carried out using the Kirby-Bauer disc diffusion method as per the Clinical Laboratory Standards Institute (CLSI) guidelines on Muller Hinton agar. Samples growing more than two organisms were discarded as contaminant. Urine samples were collected and analyzed using standard protocols. Results: Out of 14526 patients of symptomatic UTI cases (58.0% from OPD, 35.9% from LPA and 6.0% from HPA), whose urine sample was sent for microbiological culture sensitivity test, 2222 (15.2%) showed positive growth. Among the 2222 number of positive growth, 1510 (67.9%) were community acquired, 186 (8.3%) was Health care Associated UTI and 526 (23.6%) cases could not be differentiated into either group. Among 1510 community acquired UTI cases, Gram Negative Bacilli (GNB) were identified in 88.7%, Gram Positive Cocci (GPC) in 10.1% and Candida in 1.0% cases. Among 1510 community acquired UTI cases, E. coli were identified in 58.9%, K. pneumonia in 15.4%, Enterococcus in 8.5% and P. aeruginosa in 4.2% cases. Among the E. coli isolates 3rd generation cephalosporin resistance was identified in 84% in OPD vs. 92% in LPA vs. 100% in HPA, fluroquinolone resisatnce was in 82% in OPD vs. 94% in LPA vs. 1000% in HPA, piperacillin resistance in 38% in OPD vs. 63% in LPA vs. 67% in HPA, carbapenem resistance in 13% in OPD vs. 40% in LPA vs. 47% in HPA. Among the K. pneumoniae isolates 3rd generation cephalosporin resistance was identified in 78% in OPD vs. 91% in LPA vs. 100% in HPA, fluroquinolone resisatnce was in 64% in OPD vs. 86% in LPA vs. 80% in HPA, piperacillin resistance in 53% in OPD vs. 75% in LPA vs. 56% in HPA, carbapenem resistance in 14% in OPD vs. 67% in LPA vs. 55% in HPA. Among the Enterococcus isolates, vancomycin resistance was observed in 21% in OPD Vs. 24% in hospitalized cases. Conclusion: E. coli and K. pneumoniae together accounted for about two third microbiologically confirmed cases. Carbapenem resistance of about 10% in OPD cases and 50% in hospitalized patients seems alarming. Customized Anti microbial stewardship program (AMSP) at each","PeriodicalId":93299,"journal":{"name":"Infectious diseases diagnosis & treatment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135720152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-22DOI: 10.29011/2577-1515.100233
Molecular Characterisation of
{"title":"Molecular Characterisation of Cladophialophora species Isolated from Brain Abscess in a Renal Transplant Recipient","authors":"","doi":"10.29011/2577-1515.100233","DOIUrl":"https://doi.org/10.29011/2577-1515.100233","url":null,"abstract":"Molecular Characterisation of","PeriodicalId":93299,"journal":{"name":"Infectious diseases diagnosis & treatment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136099077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-18DOI: 10.29011/2577-1515.100231
Background: The aim of this study was to estimate the diagnostic precision of the rapid COVID-19 antigen test DyonCovid-Ag compared to the gold standard method Reverse Transcription quantitative Polymerase Chain Reaction (RT-qPCR) for the diagnosis of SARS-CoV-2 infection. Methods: This prospective cohort study examined samples from non-hospitalized adults and children with possible SARS-CoV-2 infection from 01/2021–12/2021. The samples were double tested using the rapid SARS-CoV-2 antigen test DyonCovid-Ag and an RT-qPCR for SARS-CoV-2. Demographic data and clinical symptoms were also collected. Results: A total of 782 individuals with median age 36.6 years (IQR: 28-48) were included in this study. The positivity for SARS-CoV-2 was 128/782 (16.4%) with RT-qPCR and 123/782 (15.7%) with RAT. The concordance of positive samples between two methods was high (123/128, 96.1%), with only five false negative but no false positive results. The sensitivity and specificity of the RAT were estimated at 96.1% (95%CI: 91.1-98.7%) and 100% (95%CI: 99.4-100.0%), respectively. Accuracy was estimated at 99.4% (95%CI: 98.5-99.8%). Conclusion: DyonCovid-Ag RAT was highly sensitive and specific and could facilitate timely diagnosis in point-of-care settings.
{"title":"Comparative Performance of a Rapid SARSCoV-2 Antigen Test with RT-PCR for the Diagnosis of COVID-19","authors":"","doi":"10.29011/2577-1515.100231","DOIUrl":"https://doi.org/10.29011/2577-1515.100231","url":null,"abstract":"Background: The aim of this study was to estimate the diagnostic precision of the rapid COVID-19 antigen test DyonCovid-Ag compared to the gold standard method Reverse Transcription quantitative Polymerase Chain Reaction (RT-qPCR) for the diagnosis of SARS-CoV-2 infection. Methods: This prospective cohort study examined samples from non-hospitalized adults and children with possible SARS-CoV-2 infection from 01/2021–12/2021. The samples were double tested using the rapid SARS-CoV-2 antigen test DyonCovid-Ag and an RT-qPCR for SARS-CoV-2. Demographic data and clinical symptoms were also collected. Results: A total of 782 individuals with median age 36.6 years (IQR: 28-48) were included in this study. The positivity for SARS-CoV-2 was 128/782 (16.4%) with RT-qPCR and 123/782 (15.7%) with RAT. The concordance of positive samples between two methods was high (123/128, 96.1%), with only five false negative but no false positive results. The sensitivity and specificity of the RAT were estimated at 96.1% (95%CI: 91.1-98.7%) and 100% (95%CI: 99.4-100.0%), respectively. Accuracy was estimated at 99.4% (95%CI: 98.5-99.8%). Conclusion: DyonCovid-Ag RAT was highly sensitive and specific and could facilitate timely diagnosis in point-of-care settings.","PeriodicalId":93299,"journal":{"name":"Infectious diseases diagnosis & treatment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135208992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-18DOI: 10.29011/2577-1515.100232
Background: Community acquired pneumonia (CAP) is a significant global health burden, with high morbidity and mortality especially in developing nations. This study assessed the changing pattern of anti microbial resistance (AMR) in CAP in secondary care centres of central India. Methodology: This was a prospective observational study conducted in 10 secondary care centres in smaller cities of Central India in the state of Madhya Pradesh. Result: Among the 1315 respiratory samples analysed, 49.5% (651/1315 samples) showed significant pathological growth out of which 47.6% (626 /1315) showed bacterial growth and 1.9% (25/1315) showed fungal growth. Gram-negative bacteria accounted for 94.2% (590/626 samples) and Gram-positive bacteria for 5.7% (36/626 samples). Klebsiella pneumoniae was the most prevalent Gram-negative isolate (45%), followed by Pseudomonas aeruginosa (24.2%) and Acinetobacter spp (15.42%). Third generation cephalosporin resistance was observed in 84.6% in E. coli and 81.1% in K. pneumoniae . Carbapenem resistance was highest in Acinetobacter spp (79.1%) followed by E. Coli (45.6%), K. pneumoniae (37.2%) and P. aeruginosa (35.7%). Colistin resistance was observed in less than 10% of all gram negative isolates with the highest being in P. aeruginosa (9.8%), K. pneumoniae (7.9%), Acinetobacter spp (6.6%) and E. Coli (2.9%). Among the gram-positive isolates, 51.7% of Staphylococcus aureus were MRSA and 9.70% were resistance to vancomycin. Conclusion: AMR is no more restricted to tertiary care centres in bigger cities of India. The menace of AMR is too critical to be ignored in primary and secondary care settings. This study highlights the importance of adopting a community level ‘One-Health’ multidisciplinary approach in human-animal health and soil-environment.
{"title":"Antimicrobial Resistance Trends in Community Acquired Pneumonia at Secondary care Centres in Central India: Time to Develop Community Antimicrobial Stewardship Program","authors":"","doi":"10.29011/2577-1515.100232","DOIUrl":"https://doi.org/10.29011/2577-1515.100232","url":null,"abstract":"Background: Community acquired pneumonia (CAP) is a significant global health burden, with high morbidity and mortality especially in developing nations. This study assessed the changing pattern of anti microbial resistance (AMR) in CAP in secondary care centres of central India. Methodology: This was a prospective observational study conducted in 10 secondary care centres in smaller cities of Central India in the state of Madhya Pradesh. Result: Among the 1315 respiratory samples analysed, 49.5% (651/1315 samples) showed significant pathological growth out of which 47.6% (626 /1315) showed bacterial growth and 1.9% (25/1315) showed fungal growth. Gram-negative bacteria accounted for 94.2% (590/626 samples) and Gram-positive bacteria for 5.7% (36/626 samples). Klebsiella pneumoniae was the most prevalent Gram-negative isolate (45%), followed by Pseudomonas aeruginosa (24.2%) and Acinetobacter spp (15.42%). Third generation cephalosporin resistance was observed in 84.6% in E. coli and 81.1% in K. pneumoniae . Carbapenem resistance was highest in Acinetobacter spp (79.1%) followed by E. Coli (45.6%), K. pneumoniae (37.2%) and P. aeruginosa (35.7%). Colistin resistance was observed in less than 10% of all gram negative isolates with the highest being in P. aeruginosa (9.8%), K. pneumoniae (7.9%), Acinetobacter spp (6.6%) and E. Coli (2.9%). Among the gram-positive isolates, 51.7% of Staphylococcus aureus were MRSA and 9.70% were resistance to vancomycin. Conclusion: AMR is no more restricted to tertiary care centres in bigger cities of India. The menace of AMR is too critical to be ignored in primary and secondary care settings. This study highlights the importance of adopting a community level ‘One-Health’ multidisciplinary approach in human-animal health and soil-environment.","PeriodicalId":93299,"journal":{"name":"Infectious diseases diagnosis & treatment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135255755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.29011/2577-1515.100210
{"title":"Correlation of Clinical Findings with Innate Immunity Against SARS-CoV-2 and Nucleic Acid Expression of SARS-CoV-2 Among Patients in Mongolia","authors":"","doi":"10.29011/2577-1515.100210","DOIUrl":"https://doi.org/10.29011/2577-1515.100210","url":null,"abstract":"","PeriodicalId":93299,"journal":{"name":"Infectious diseases diagnosis & treatment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135897703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-13DOI: 10.29011/2577-1515.100207
{"title":"Modeling COVID-19 in Different Countries as Sequences of SI Waves","authors":"","doi":"10.29011/2577-1515.100207","DOIUrl":"https://doi.org/10.29011/2577-1515.100207","url":null,"abstract":"","PeriodicalId":93299,"journal":{"name":"Infectious diseases diagnosis & treatment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135957280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-10DOI: 10.29011/2577-1515.100183
{"title":"Strategies and Control the Seasonal Influenza","authors":"","doi":"10.29011/2577-1515.100183","DOIUrl":"https://doi.org/10.29011/2577-1515.100183","url":null,"abstract":"","PeriodicalId":93299,"journal":{"name":"Infectious diseases diagnosis & treatment","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46058710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-16DOI: 10.29011/2577-1515.100182
Robert Thomas, J. Aldous, R. Forsyth, A. Chater, Madeleine Williams
Background: Gut microfloral dysbiosis is known to affect the majority individuals suffering with a Covid-19 infection. This study evaluated whether a specific lactobacillus and inulin blend, which aimed to improve gut health, could reduce the severity of early and chronic Covid-19 symptoms. Methods: From May 2020 to May 2021, we evaluated 126 participants with Covid-19, with an average duration of symptoms of 108 days, who were given 30 days of this pre and probiotic capsule within the ongoing UK national Phyto-v study. Symptoms were recorded using the validated Cough Symptom Score, the Subjective Well-Being questionnaire and the Chandler fatigue questionnaire. The group was analysed as a whole and then subdivided into 40 (32%) in an early phase of infection (average symptoms 10 days before baseline) and the 86 (68%) in a chronic phase (average symptoms 120 days before trial baseline). Results: Cough, fatigue and subjective well-being scores significantly improved over the 30 days in both the early and chronic phase cohorts. Participants who were more likely to have gut dysbiosis at trial entry, such as sedentary, hospitalised, older males with GI symptoms, had a statistically significantly better response to the probiotics. Gut symptoms improved in 25 of 31 (82%) who reported them at baseline. Two (1.5%) patients reported mild increased bloating and diarrhoea. Discussion: Following this nutritional intervention, participants had a significant improvement in GI and non-GI symptoms resulting in a meaningful improvement in overall well-being. Although some participants with early disease would have improved spontaneously, such a rapid improvement in the majority who had been experiencing symptoms for over 6 months, was clinically relevant and welcomed, especially among those more likely to have pre-existing gut dysbiosis. Going forward, our research group are now evaluating whether intake of this blend now known as yourgutplus+, could also enhance antibody titres levels post Covid vaccination. Infectious Diseases Diagnosis & Treatment Thomas R, et al. Infect Dis Diag Treat 5: 182. https://www.doi.org/ 10.29011/25771515.100182 https://www.gavinpublishers.com/ Citation: Thomas R, Aldous J, Forsyth R, Chater A, Williams M (2021) The Influence of a blend of Probiotic Lactobacillus and Prebiotic Inulin on the Duration and Severity of Symptoms among Individuals with Covid-19. Infect Dis Diag Treat 5: 182. DOI: 10.29011/2577-1515.100182 2 Volume 5; Issue 01 Infect Dis Diag Treat, an open access journal ISSN: 2577-1515
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