Pub Date : 2021-09-07DOI: 10.24966/ncp-878x/100085
Hayri Gözlükgiller
In our study, the toxic effects of cigarette smoke exposure on central nervous system and the protective role of Omega 3 and Vitamin D against these toxic effects were investigated at biochemical and histological level.
{"title":"The Protective Effect of Omega 3 and Vitamin D in Preventing Damage Occurring in Central Nervous System of Neonatal Rats Exposed to Cigarette Smoke in Intrauterine Period","authors":"Hayri Gözlükgiller","doi":"10.24966/ncp-878x/100085","DOIUrl":"https://doi.org/10.24966/ncp-878x/100085","url":null,"abstract":"In our study, the toxic effects of cigarette smoke exposure on central nervous system and the protective role of Omega 3 and Vitamin D against these toxic effects were investigated at biochemical and histological level.","PeriodicalId":93307,"journal":{"name":"Journal of clinical pediatrics and neonatology","volume":"110 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75995985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-07DOI: 10.24966/ncp-878x/100086
Renato Barcellos Rédua
To verify the prevalence of Sleep Bruxism (SB) in children in the last 3 decades and to verify the possible association of this condition with type of delivery, breastfeeding period, oral habits and gender
{"title":"Prevalence of Sleep Bruxism in Brazilian children and association with type of delivery, breastfeeding period and oral habits with follow-up in 3 decades","authors":"Renato Barcellos Rédua","doi":"10.24966/ncp-878x/100086","DOIUrl":"https://doi.org/10.24966/ncp-878x/100086","url":null,"abstract":"To verify the prevalence of Sleep Bruxism (SB) in children in the last 3 decades and to verify the possible association of this condition with type of delivery, breastfeeding period, oral habits and gender","PeriodicalId":93307,"journal":{"name":"Journal of clinical pediatrics and neonatology","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87329849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-07DOI: 10.24966/ncp-878x/100080
Bodhrun Naher
Viral hepatitis is a serious health problem globally and in endemic countries like Bangladesh. Viral hepatitis may present as mono-infection or co-infection caused by Hepatitis A Virus (HAV), hepatitis B virus, hepatitis C virus, hepatitis D virus, and Hepatitis E Virus (HEV)
{"title":"Seroprevalence and Co-infection of Hepatitis A and Hepatitis E Viruses in children - A hospital-based study in Bangladesh","authors":"Bodhrun Naher","doi":"10.24966/ncp-878x/100080","DOIUrl":"https://doi.org/10.24966/ncp-878x/100080","url":null,"abstract":"Viral hepatitis is a serious health problem globally and in endemic countries like Bangladesh. Viral hepatitis may present as mono-infection or co-infection caused by Hepatitis A Virus (HAV), hepatitis B virus, hepatitis C virus, hepatitis D virus, and Hepatitis E Virus (HEV)","PeriodicalId":93307,"journal":{"name":"Journal of clinical pediatrics and neonatology","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90305738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-07DOI: 10.24966/ncp-878x/100083
S. Fonseca, Centro Hospitalar Universitário De São João
Abnormal red blood cell indices are frequently missed among newborns that perform blood tests for any clinical reason.
由于任何临床原因进行血液检查的新生儿经常遗漏异常红细胞指数。
{"title":"Valorization of Erythrocyte Indices in the Neonatal Period - A Pilot Study","authors":"S. Fonseca, Centro Hospitalar Universitário De São João","doi":"10.24966/ncp-878x/100083","DOIUrl":"https://doi.org/10.24966/ncp-878x/100083","url":null,"abstract":"Abnormal red blood cell indices are frequently missed among newborns that perform blood tests for any clinical reason.","PeriodicalId":93307,"journal":{"name":"Journal of clinical pediatrics and neonatology","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84456557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-07DOI: 10.24966/ncp-878x/100084
E. Wright
Swallowing and feeding difficulties associated with Neurological Impairment (NI) can impact on children’s ability to meet nutritional requirements orally and so enteral nutrition is often required.
与神经损伤(NI)相关的吞咽和喂养困难会影响儿童口服满足营养需求的能力，因此通常需要肠内营养。
{"title":"Benefits of Using of a Low-Calorie Whey Peptide Enteral Formula in Children with Gastrointestinal Impairment, Complex Condition and Having Lower Energy Needs - A Series of Clinical Case Reports","authors":"E. Wright","doi":"10.24966/ncp-878x/100084","DOIUrl":"https://doi.org/10.24966/ncp-878x/100084","url":null,"abstract":"Swallowing and feeding difficulties associated with Neurological Impairment (NI) can impact on children’s ability to meet nutritional requirements orally and so enteral nutrition is often required.","PeriodicalId":93307,"journal":{"name":"Journal of clinical pediatrics and neonatology","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89965875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-07DOI: 10.24966/ncp-878x/100079
Kathryn Simpson
The nutritional management of the complex needs child with impaired gastrointestinal function can be challenging.
肠胃功能受损的复杂需求儿童的营养管理是具有挑战性的。
{"title":"Nutritional Intervention in Paediatric Gastroesophageal Reflux Disease: Clinical Case Reports","authors":"Kathryn Simpson","doi":"10.24966/ncp-878x/100079","DOIUrl":"https://doi.org/10.24966/ncp-878x/100079","url":null,"abstract":"The nutritional management of the complex needs child with impaired gastrointestinal function can be challenging.","PeriodicalId":93307,"journal":{"name":"Journal of clinical pediatrics and neonatology","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77565322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.46439/pediatrics.1.003
Li Yin, Kai-Fen Chang, Kyle J Nakamura, Louise Kuhn, Grace M Aldrovandi, Maureen M Goodenow
Mother-to-child transmission (MTCT) through breastfeeding remains a major source of pediatric HIV-1 infection worldwide. To characterize plasma HIV-1 subtype C populations from infected mothers during pregnancy that related to subsequent breast milk transmission, an exploratory study was designed to apply next generation sequencing and a custom bioinformatics pipeline for HIV-1 gp41 extending from heptad repeat region 2 (HR2) through the membrane proximal external region (MPER) and the membrane spanning domain (MSD). MPER harbors linear and highly conserved epitopes that repeatedly elicits HIV-1 neutralizing antibodies with exceptional breadth. Viral populations during pregnancy from women who transmitted by breastfeeding, compared to those who did not, displayed greater biodiversity, more frequent amino acid polymorphisms, lower hydropathy index and greater positive charge. Viral characteristics were restricted to MPER, failed to extend into flanking HR2 or MSD regions, and were unrelated to predicted neutralization resistance. Findings provide novel parameters to evaluate an association between maternal MPER variants present during gestation and lactogenesis with subsequent transmission outcomes by breastfeeding.
Importance: HIV-1 transmission through breastfeeding accounts for 39% of MTCT and continues as a major route of pediatric infection in developing countries where access to interventions for interrupting transmission is limited. Identifying women who are likely to transmit HIV-1 during breastfeeding would focus therapies, such as broad neutralizing HIV monoclonal antibodies (bn-HIV-Abs), during the breastfeeding period to reduce MTCT. Findings from our pilot study identify novel characteristics of gestational viral MPER quasispecies related to transmission outcomes and raise the possibility for predicting MTCT by breastfeeding based on identifying mothers with high-risk viral populations.
通过母乳喂养的母婴传播（MTCT）仍然是全球儿童HIV-1感染的主要来源。为了表征妊娠期间感染母亲的血浆HIV-1亚型C人群，其与随后的母乳传播有关，设计了一项探索性研究，以应用HIV-1gp41的下一代测序和定制生物信息学管道，该管道从七肽重复区2（HR2）延伸到膜近端外部区（MPER）和膜跨接结构域（MSD）。MPER含有线性和高度保守的表位，这些表位以非凡的广度反复引发HIV-1中和抗体。与未经母乳喂养的女性相比，通过母乳喂养传播的女性在怀孕期间的病毒种群表现出更大的生物多样性、更频繁的氨基酸多态性、更低的水病指数和更大的正电荷。病毒特征仅限于MPER，未能延伸到HR2或MSD侧翼区域，并且与预测的中和耐药性无关。研究结果提供了新的参数来评估妊娠期出现的母体MPER变异和产乳与随后母乳喂养的传播结果之间的关系。重要性：通过母乳喂养传播的HIV-1占MTCT的39%，并且在发展中国家仍然是儿科感染的主要途径，在这些国家，阻断传播的干预措施有限。识别母乳喂养期间可能传播HIV-1的女性将在母乳喂养期间重点治疗，如广泛中和HIV单克隆抗体（bn HIV Abs），以减少MTCT。我们的初步研究结果确定了妊娠期病毒MPER准种与传播结果相关的新特征，并提高了通过母乳喂养预测MTCT的可能性。
{"title":"Unique genotypic features of HIV-1 C gp41 membrane proximal external region variants during pregnancy relate to mother-to-child transmission via breastfeeding.","authors":"Li Yin, Kai-Fen Chang, Kyle J Nakamura, Louise Kuhn, Grace M Aldrovandi, Maureen M Goodenow","doi":"10.46439/pediatrics.1.003","DOIUrl":"10.46439/pediatrics.1.003","url":null,"abstract":"<p><p>Mother-to-child transmission (MTCT) through breastfeeding remains a major source of pediatric HIV-1 infection worldwide. To characterize plasma HIV-1 subtype C populations from infected mothers during pregnancy that related to subsequent breast milk transmission, an exploratory study was designed to apply next generation sequencing and a custom bioinformatics pipeline for HIV-1 gp41 extending from heptad repeat region 2 (HR2) through the membrane proximal external region (MPER) and the membrane spanning domain (MSD). MPER harbors linear and highly conserved epitopes that repeatedly elicits HIV-1 neutralizing antibodies with exceptional breadth. Viral populations during pregnancy from women who transmitted by breastfeeding, compared to those who did not, displayed greater biodiversity, more frequent amino acid polymorphisms, lower hydropathy index and greater positive charge. Viral characteristics were restricted to MPER, failed to extend into flanking HR2 or MSD regions, and were unrelated to predicted neutralization resistance. Findings provide novel parameters to evaluate an association between maternal MPER variants present during gestation and lactogenesis with subsequent transmission outcomes by breastfeeding.</p><p><strong>Importance: </strong>HIV-1 transmission through breastfeeding accounts for 39% of MTCT and continues as a major route of pediatric infection in developing countries where access to interventions for interrupting transmission is limited. Identifying women who are likely to transmit HIV-1 during breastfeeding would focus therapies, such as broad neutralizing HIV monoclonal antibodies (bn-HIV-Abs), during the breastfeeding period to reduce MTCT. Findings from our pilot study identify novel characteristics of gestational viral MPER quasispecies related to transmission outcomes and raise the possibility for predicting MTCT by breastfeeding based on identifying mothers with high-risk viral populations.</p>","PeriodicalId":93307,"journal":{"name":"Journal of clinical pediatrics and neonatology","volume":"1 1","pages":"9-20"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8454918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39440492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-31DOI: 10.24966/NCP-878X/100063
N. F. Onuegbu
Despite the use of many cultural-handling practices to facilitate neuromotor development in African children, there is no documentation on their purpose and effectiveness.
尽管使用了许多文化处理方法来促进非洲儿童的神经运动发展，但没有关于其目的和有效性的文件。
{"title":"Child Handling Cultural Practices For Neuromotor Development In Infants In A Cohort Of African Population: A Prospective Analytical Study","authors":"N. F. Onuegbu","doi":"10.24966/NCP-878X/100063","DOIUrl":"https://doi.org/10.24966/NCP-878X/100063","url":null,"abstract":"Despite the use of many cultural-handling practices to facilitate neuromotor development in African children, there is no documentation on their purpose and effectiveness.","PeriodicalId":93307,"journal":{"name":"Journal of clinical pediatrics and neonatology","volume":"5 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78862232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-15DOI: 10.24966/ncp-878x/100061
V. Carvalho
DiGeorge syndrome is mainly caused by microdeletion of chromosome 22 (22q11.2) and is characterized by a broad phenotypic spectrum.
DiGeorge综合征主要由22号染色体(22q11.2)微缺失引起，具有广泛的表型谱。
{"title":"DiGeorge Syndrome In A Newborn - A Diagnostic Challenge","authors":"V. Carvalho","doi":"10.24966/ncp-878x/100061","DOIUrl":"https://doi.org/10.24966/ncp-878x/100061","url":null,"abstract":"DiGeorge syndrome is mainly caused by microdeletion of chromosome 22 (22q11.2) and is characterized by a broad phenotypic spectrum.","PeriodicalId":93307,"journal":{"name":"Journal of clinical pediatrics and neonatology","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75395505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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