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Chemical and pharmacological characterization of triptans 曲坦类药物的化学和药理特性
Pub Date : 2019-07-01 DOI: 10.2478/orvtudert-2019-0007
Kelemen Hajnal, Filep Bíborka-Erzsébet, P. Attila
Abstract Triptans are specific drugs for migraine attack, their use leads to selective vasoconstriction, while the inflammatory condition that usually occurs during migraine is reduced. The structurally indolamine derivatives are selective agonists of the serotonin 1B/1D receptor. This review presents the history, representatives, production, and physico-chemical properties of triptans, but also discusses their pharmacological properties and mechanism of action.
曲坦类药物是治疗偏头痛的特异性药物,其使用可导致选择性血管收缩,同时减少偏头痛期间通常发生的炎症状况。结构上吲哚胺衍生物是5 -羟色胺1B/1D受体的选择性激动剂。本文综述了曲坦类药物的历史、代表、生产和理化性质,并对其药理特性和作用机制进行了讨论。
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引用次数: 0
Aluminium contamination of several types of tea 几种茶叶的铝污染
Pub Date : 2019-07-01 DOI: 10.2478/orvtudert-2019-0003
Fogarasi Erzsébet, Fülöp Ibolya, B. Zsuzsa, Márton Kincső, Croitoru Mircea Dumitru
Abstract Introduction: Camellia sinensis, a widely used plant, optimally grows in a low pH soil that in most cases contains high amounts of aluminum. Objectives: The aluminum content of the tea obtained from Camellia sinensis and other plants was compared. The influence of pH on the aluminum content of the tea was also measured. Materials and methods: The aluminum content of 48 samples was measured using a colorimetric method. The method is based on the ability of aluminum to form a stable complex with xylenol orange at low pH; this complex has an absorption maximum of 555 nm. Results: The method was validated for tea obtained with water and for tea obtained with water containing citric acid. The method proved linear over the rage of 0.7 – 7 ug/ml, coefficient of variation ranged between 2.6 – 7.68% (was dependent on the pH of the solution used to obtain the tea), accuracy was suitable for quantitative measurement (92.39-102.92%) and the complex proved to be stable for at least 1 hour. The following concentrations were measured: green tea (1.59 - 7.70 µg/ml), black tea (1.39 - 5.60 µg/ml), fruit tea (1.01 - 5.63 µg/ml) and herbal tea (1.03 - 5.24 µg/ml). Conclusion: The method proved useful and easily applicable for screening aluminum content of plants used for tea brewing. Camellia sinensis both green and black types had significantly higher aluminum contents than other type of teas. Adding citric acid, as would result from use of lemon juice, significantly increased the aluminum extraction from the plants used for tea brewing.
摘要简介:山茶是一种应用广泛的植物,适宜生长在含铝量高的低pH土壤中。目的:比较山茶与其他植物茶中铝的含量。测定了pH值对茶叶铝含量的影响。材料与方法:采用比色法测定了48份样品的铝含量。该方法是基于铝在低pH下与二甲酚橙形成稳定配合物的能力;该配合物的最大吸收波长为555nm。结果:该方法适用于水泡茶和含柠檬酸水泡茶。结果表明,该方法在0.7 ~ 7 ug/ml范围内呈线性,变异系数在2.6 ~ 7.68%之间(取决于制茶液的pH值),准确度为92.39 ~ 102.92%,配合物稳定时间至少为1小时。测量了以下浓度:绿茶(1.59 - 7.70µg/ml),红茶(1.39 - 5.60µg/ml),果茶(1.01 - 5.63µg/ml)和凉茶(1.03 - 5.24µg/ml)。结论:该方法简便易行,可用于泡茶用植物铝含量的筛选。绿茶和黑茶的铝含量均显著高于其他茶种。加入柠檬酸,由于柠檬汁的使用,显著增加了从用于泡茶的植物中提取的铝。
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引用次数: 0
Occurrence of internal diseases in the premotor phase of Parkinson’s disease by analyzing a large database covering a whole population 通过分析覆盖整个人群的大型数据库,研究帕金森病运动前期内部疾病的发生
Pub Date : 2019-07-01 DOI: 10.2478/orvtudert-2019-0009
Szatmári Szabolcs, A. András, Oberfrank Ferenc, B. Dániel
Abstract The premotor phase of Parkinson’s disease (PD) precedes the appearance of motor symptoms by years. Many non-motor diseases have been associated with an increased risk of developing PD, but results of these studies are conflicting. The aim of this study was to investigate the occurrence of certain internal diseases (metabolic, circulatory, gastrointestinal) based on diagnosis codes, before the diagnosis of PD. There were 5209 patients included in the study who received diagnosis of PD at least in 2 years and we analyzed data retrospectively between 2004 and 2016. Out of metabolic diseases dyslipidemia (41%) and diabetes mellitus (32%), out of circulatory diseases hypertension (89%) and ischemic heart disease (51%) and out of gastrointestinal diseases gastroesophageal reflux disease (51%) and gallstones (25%) were the first two most common disorders in the examined PD patients. This is the first study in Hungary which analyzed PD in a large database in the context of internal diseases, and raised the possibility of a link between dyslipidemias, diabetes mellitus, hypertension, ischemic heart disease, gastooesophagial reflux, gallstones and PD.
帕金森病(PD)的运动前期比运动症状的出现早几年。许多非运动疾病与帕金森病的风险增加有关,但这些研究的结果是相互矛盾的。本研究的目的是根据诊断代码调查PD诊断前某些内部疾病(代谢、循环、胃肠)的发生情况。研究中有5209名至少在2年内被诊断为PD的患者,我们回顾性分析了2004年至2016年的数据。在代谢疾病中,血脂异常(41%)和糖尿病(32%),在循环系统疾病中,高血压(89%)和缺血性心脏病(51%),在胃肠道疾病中,胃食管反流病(51%)和胆结石(25%)是PD患者最常见的前两种疾病。这是匈牙利第一个在内部疾病背景下分析PD的大型数据库的研究,并提出了血脂异常、糖尿病、高血压、缺血性心脏病、胃食管反流、胆结石和PD之间联系的可能性。
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引用次数: 0
An event that impacted the Transylvanian pharmacist education 100 years ago 100年前影响特兰西瓦尼亚药剂师教育的事件
Pub Date : 2019-07-01 DOI: 10.2478/orvtudert-2019-0005
Péter H. Mária
Abstract In Kolozsvár, on 17th of September 1872, a Hungarian royal university was founded with 4 faculties 1- Law and Political Sciences, 2. Medical, 3. Arts (liberal), Language and History of Science, 4. Mathemathics and Natural History faculties. In 1881 the University picked up the Ferencz József University of Science name. There was no independent Medicine trainingfacultyt at this time yet. Pharmacists were taught in the Medical and Natural History faculties. In December 1918, during the first world war, Kolozsvár was moved under Romanian rule. On the 9th of May in 1919 the Romanian authorities called the acadamic senate (school staff) to do loyalty oath for the Romanian king.This was refused by the university teachers. After this event, teachers were moved out from this building along with the entire equipement of the University, and the place was occupied by the Romanian university. As, by this, theHungarian language acadamic education became impossible the first stage of the life of(Hungarian King) Ferencz József University of Sciense ended. First, the major part of theprofessors and students emigrated to Budapest while later on in 1921 the University wastemporarily established in Szeged. The University in Szeged took not onlythe legal continuity of the institute through its name but its professors also maintained and cherished all the traditions of the institute through many long coming years. Starting from 1921/1922 many student with transilvanian origin obtained pharmacist’s degree here many of whom later returned and worked in their native country.
在Kolozsvár, 1872年9月17日,一所匈牙利皇家大学成立,有四个学院1-法律和政治科学,2。医疗、3。文科(文科),语言和科学史,4。数学和自然历史系。1881年,大学更名为费伦茨József科学大学。当时还没有独立的医学培训机构。药剂师在医学和自然史学院任教。1918年12月,在第一次世界大战期间,Kolozsvár被转移到罗马尼亚统治之下。1919年5月9日,罗马尼亚当局召集学术参议院(学校教职员工)为罗马尼亚国王宣誓效忠。这遭到了大学老师们的拒绝。在这次事件之后,教师和大学的所有设备都被搬出了这座建筑,这个地方被罗马尼亚大学占用。因此,匈牙利语学术教育变得不可能,(匈牙利国王)费伦茨József科学大学生命的第一阶段结束了。首先,大部分教授和学生移民到布达佩斯,后来在1921年,大学暂时建立在塞格德。塞格德大学不仅通过其名称保留了该研究所的法律连续性,而且其教授也在未来的许多年里保持并珍视该研究所的所有传统。从1921/1922年开始,许多来自特兰西瓦尼亚的学生在这里获得了药剂师学位,其中许多人后来返回并在他们的祖国工作。
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引用次数: 0
Determination of corticosterone from rat hair samples by HPLC-MS method HPLC-MS法测定大鼠毛发样品中皮质酮的含量
Pub Date : 2019-07-01 DOI: 10.2478/orvtudert-2019-0008
Ferencz Elek, Boda Ferenc, Gáll Zsolt, Kolcsár Melinda, Donáth-Nagy Gabriella, Vancea Szende
Abstract Corticosterone is an adrenocortical steroid hormone with glucocorticoid and mineralocorticoid effects. Based on previous studies, the plasma level of corticosterone correlates with the stress exposure of rodents. Because the half-life of corticosterone in blood is short, its plasma concentration can be used as an acute stress marker. But hair is accumulating the systemic and locally produced corticosterone, therefore it can be used to study chronic stress. However, the accurate quantification of corticosterone is an analytical challenge owing to the very low amount of hormone found in a complicated biological matrix. The high performance liquid chromatography coupled with mass spectrometry (HPLC-MS) can provide the required selectivity and sensitivity for this purpose. Currently published methods for corticosterone quantification involve complicated sample preparation and long run time. Accordingly, the aims of the study were to simplify the extraction method of the corticosterone from rat hair samples and to develop an optimized HPLC-MS method for the accurate quantification. The rat hair samples were washed with methanol, dried and cut, then extracted with methanol at room temperature for 24 hours. The lipids were precipitated with formic acid aqueous solution and eliminated by centrifugation. The corticosterone was separated from other compounds with reverse phase chromatography using acetonitrile and 0,1% aqueous solution of formic acid as mobile phase. The detection was performed in positive SIM mode measuring the 347 m/z molecular ion. A six point calibration was performed in the range of 0,5-20 ng/ml, the accuracy was tested with quality control samples at two different concentration level. The total run time is only 4,2 minutes and the lower limit of quantification (LLOQ) is 0,5 ng/ml, with 10 pg absolute sensitivity. By determining the quantity of the hormone for a well-defined hair region, based on the speed of hair growth, we can characterize the retrospective stress exposure of the animals in different conditions.
皮质酮是一种具有糖皮质激素和矿皮质激素作用的肾上腺皮质类固醇激素。根据以往的研究,血浆皮质酮水平与啮齿动物的应激暴露有关。由于皮质酮在血液中的半衰期短,其血浆浓度可作为急性应激标志物。但是头发会积累全身和局部产生的皮质酮,因此它可以用来研究慢性压力。然而,皮质酮的准确定量是一项分析挑战,因为在复杂的生物基质中发现的激素量非常低。高效液相色谱-质谱联用技术(HPLC-MS)可提供所需的选择性和灵敏度。目前公布的皮质酮定量方法涉及复杂的样品制备和较长的运行时间。因此,本研究的目的是简化大鼠毛发样品中皮质酮的提取方法,并建立一种优化的高效液相色谱-质谱法以准确定量。将大鼠毛发样品用甲醇洗涤、干燥、切割,然后在室温下用甲醇提取24小时。脂质用甲酸水溶液沉淀,离心除去。以乙腈和0.1%甲酸水溶液为流动相,采用反相色谱法分离皮质酮和其他化合物。在正SIM模式下进行检测,测量347 m/z分子离子。在0.5 ~ 20 ng/ml范围内进行了6点校准,并以两种不同浓度水平的质控样品进行了准确度测试。总运行时间仅为4.2 min,定量下限(LLOQ)为0.5 ng/ml,绝对灵敏度为10 pg。根据毛发生长的速度,在一个明确的毛发区域确定激素的数量,我们可以描述动物在不同条件下的回顾性应激暴露。
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引用次数: 1
Presence and upregulation of Transient Receptor Potential Vanilloid 1 (TRPV1) and Ankyrin 1 (TRPA1) in translational rat endometriosis model 翻译大鼠子宫内膜异位症模型中瞬时受体电位香草样蛋白1 (TRPV1)和锚蛋白1 (TRPA1)的存在和上调
Pub Date : 2019-07-01 DOI: 10.2478/orvtudert-2019-0011
Pohóczky Krisztina, Bohonyi Noémi, M. Péter, Kajtár Béla, H. Zsuzsanna
Abstract The Transient Receptor Potential Vanilloid 1 (TRPV1) and Ankyrin 1 (TRPA1) are non-selective cation channels predominantly localized on capsaicin-sensitive sensory neurons; however both receptors have been described in non-neuronal tissues. It has been published that both receptors upregulated in peritoneal endometriosis in humans. Our research group demonstrated that TRPA1 and TRPV1 expression is elevated in human deep infiltrating endometriosis (DIE) lesions and the receptors have an estrogen-dependent expression pattern in rat endometrium. Here, we investigated the expression changes of TRPA1/V1 and the role of the capsaicin-sensitive sensory-nerve endings in a rat model of peritoneal endometriosis. Peritoneal endometriosis was surgically induced in 8-week-old female rats (n=7-7) for 2-weeks (acute condition) and 8-weeks (chronic condition). TRPA1/V1 mRNAs were quantified with quantitative polymerase chain reaction (qPCR). The expression levels were compared with the results obtained earlier from human DIE samples. The blockade of the TRPA1/V1 expressing capsaicin-sensitive nerve endings was induced with resiniferatoxin (RTX), followed by the measurement of the weight and size of the endometriosis lesions. We detected TRPV1 and TRPA1 mRNA in normal rat endometrium, their expression was not altered in sham-operated animals. In chronic, but not in acute endometriosis the expression was significantly elevated in the lesions, which results are consistent with our previous findings in human DIE. The elimination of capsaicin-sensitive nerve endings decreased the weight of the endometriosis lesions while the size of the ectopic tissue was not altered. Taken together, our results obtained from the rat endometriosis model are consistent with the previous human results, therefore this model is considered to have translational significance and it is suitable for functional analysis of the ion channels. The local, non-neuronal TRPA1 and TRPV1 might play a role in inflammation and sensory neuronal activation in endometriosis related pain, which is mediated by a broad range of pro-inflammatory molecules.
瞬时受体电位香草蛋白1 (TRPV1)和锚蛋白1 (TRPA1)是主要定位于辣椒素敏感感觉神经元上的非选择性阳离子通道;然而,这两种受体都在非神经元组织中被描述过。已经发表的研究表明,这两种受体在人类腹膜子宫内膜异位症中上调。本课课组发现TRPA1和TRPV1在人深部浸润性子宫内膜异位症(DIE)病变中表达升高,在大鼠子宫内膜中具有雌激素依赖性表达模式。本研究探讨了TRPA1/V1在大鼠腹膜子宫内膜异位症模型中的表达变化及辣椒素敏感感觉神经末梢的作用。手术诱导8周龄雌性大鼠(n=7-7)腹膜子宫内膜异位症2周(急性)和8周(慢性)。采用定量聚合酶链反应(qPCR)对TRPA1/V1 mrna进行定量分析。将表达水平与早期从人类DIE样品中获得的结果进行比较。用树脂干扰素(RTX)阻断表达辣椒素敏感神经末梢的TRPA1/V1,然后测量子宫内膜异位症病变的重量和大小。我们检测了正常大鼠子宫内膜中TRPV1和TRPA1 mRNA的表达,假手术动物中TRPV1和TRPA1 mRNA的表达没有改变。在慢性而非急性子宫内膜异位症中,病变中的表达显著升高,这一结果与我们之前在人类DIE中的发现一致。消除辣椒素敏感神经末梢减少了子宫内膜异位症病变的重量,而异位组织的大小没有改变。综上所述,我们从大鼠子宫内膜异位症模型中得到的结果与之前的人类结果一致,因此认为该模型具有翻译意义,适合于离子通道的功能分析。局部非神经元TRPA1和TRPV1可能在子宫内膜异位症相关疼痛的炎症和感觉神经元激活中发挥作用,这是由广泛的促炎分子介导的。
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引用次数: 0
The Antidepressants and the Metabolic Syndrome 抗抑郁药和代谢综合征
Pub Date : 2018-12-01 DOI: 10.2478/orvtudert-2018-0009
Kolcsár Melinda, Gáll Zsolt, Bába László-István, K. Zoltán
Abstract The relationship between antidepressants (AD) and metabolic syndrome (MS) can be approached from many perspectives. We can start from the mutuality of depression and MS: depression often causes MS and vice versa; however, the two diseases aggravate each other. Altered glucocorticoid secretion - among others - may be a common etiological factor for depression and MS. Enhanced glucocorticoid production leads both to sleep disorders and insulin resistance, and several antidepressants cause obesity and insulin resistance. In addition, sympathetic nervous system activity increases in depression, together with the elevated production of counter-insulin hormones such as catecholamines (adrenaline) and glucocorticoids. From the components of MS, body weight changes can be most easily followed by the patient. The obesogenic mechanisms of AD drugs are different. The H1-receptor blocking agents have the most important weight gaining effect, followed by the 5-HT2c-receptor blocking and/or down-regulating ADs. The fattening effect of mirtazapine, paroxetine, and tricyclic antidepressants are based on such central mechanisms. Blocking of alpha1-receptors contributes to the obesogenic effects of certain drugs by inducing sedation: this has been confirmed in case of imipramine, amitriptyline, and doxepin. Fluoxetine behaves differently depending on the dose and duration of treatment: while at the usual doses it induces weight loss at the beginning of therapy, its initial anorexigenic effects reverses during prolonged use; while its activation effect at high doses is favorable in bulimia. The selective noradrenaline reuptake inhibitor reboxetine reduces appetite, similarly to bupropion, which inhibits dopamine reuptake as well. We highlight the effect of fluoxetine on direct adipogenicity, mentioning its preadipocyte-adipocyte transformation-reducing and adipocyte proliferation-inhibiting activity, as well as its ability to enhance fat cell autophagy.
抗抑郁药(AD)与代谢综合征(MS)的关系可以从多个角度探讨。我们可以从抑郁症和多发性硬化症的相互关系入手:抑郁症往往导致多发性硬化症,反之亦然;然而,这两种疾病相互加剧。糖皮质激素分泌的改变可能是抑郁症和多发性硬化症的常见病因之一。糖皮质激素分泌的增加会导致睡眠障碍和胰岛素抵抗,而一些抗抑郁药物会导致肥胖和胰岛素抵抗。此外,抑郁症患者交感神经系统活动增加,同时抗胰岛素激素如儿茶酚胺(肾上腺素)和糖皮质激素的分泌增加。从MS的组成来看,体重的变化最容易被患者跟踪。AD药物致肥机制不同。h1受体阻滞剂具有最重要的增重作用,其次是5- ht2c受体阻滞剂和/或下调ad。米氮平、帕罗西汀和三环抗抑郁药的增肥作用就是基于这样的中心机制。α - 1受体的阻断通过诱导镇静有助于某些药物的致肥作用:这已在丙咪嗪、阿米替林和多塞平的情况下得到证实。氟西汀的作用因剂量和治疗持续时间的不同而不同:在常规剂量下,氟西汀在治疗开始时引起体重减轻,但在长期使用期间,其最初的厌氧作用会逆转;而在高剂量时,其活化作用对暴食症有利。选择性去甲肾上腺素再摄取抑制剂瑞波西汀可以减少食欲,类似于抑制多巴胺再摄取的安非他酮。我们强调了氟西汀对直接脂肪生成的影响,提到了它的前脂肪细胞-脂肪细胞转化减少和脂肪细胞增殖抑制活性,以及它增强脂肪细胞自噬的能力。
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引用次数: 0
Liquid chromatographic enantioseparation of thalidomide and its derivatives on cyclodextrin-bonded stationary phases 沙利度胺及其衍生物环糊精键合固定相的液相色谱对映分离
Pub Date : 2018-12-01 DOI: 10.2478/orvtudert-2018-0014
S. István, Foroughbakhshfasaei Mohammadhassan, D. Máté, Noszál Béla, Tóth Gergő
Abstract The chiral separation of three racemic immunomodulatory drugs, thalidomide, pomalidomide and lenalidomide was studied, using three cyclodextrin bonded stationary phases (β-, hydroxypropyl-β- and carboxymethyl-β-CD) in reversed-phase and polar organic mode. In polar organic mode, using acetonitrile and methanol, no chiral separation was observed. In reversed-phase mode pomalidomide showed chiral interactions with all selectors, while lenalidomide showed no chiral interactions with any of the cyclodextrins employed. Thalidomide showed chiral interactions with β-and carboxymethyl-β-CD, only. Based on these observations it can be concluded that the oxo group at position two is necessary for chiral recognition, while the aromatic primary amine group enhances it. Orthogonal experimental design was used to investigate the effect of the eluent composition, flow rate, and the column temperature on chiral separation. Concentration of the organic modifier was the most important factor among the investigated three variables showing high impact on the chiral separations. In the case of thalidomide optimized parameters (β-cyclodextrin-based stationary phase, 0.1% acetic acid/acetonitrile 95/5 (v/v), 5 °C column temperature, 0.6 ml/min flow rate) resulted in a resolution of 1.68 ± 0.02 between enantiomers. For pomalidomide, this value was 2.70 ± 0.02, under the circumstances as follows: β-cyclodextrin-based stationary phase, 0.1% acetic acid/acetonitrile 90/10 (v/v), 15 °C column temperature and 0.8 mL/min flow rate. Utilizing the experimental conditions employed on an LC-MS/MS system, concentrations as low as 2 ng/mL could be determined from mouse plasma for both substances. Elution sequences were determined with enantiopure standards and in both cases the R-enantiomers eluted first. The methods developed are suitable for the chiral separation of the abovementioned compounds and are sound starting points for bioanalytical method development.
摘要采用三种环糊精键合固定相(β-、羟丙基-β-和羧甲基-β- cd),以反相极性有机方式研究了沙利度胺、泊马度胺和来那度胺三种外消旋免疫调节药物的手性分离。在极性有机模式下,使用乙腈和甲醇,未观察到手性分离。在反相模式下,来那度胺与所有选择物均表现出手性相互作用,而来那度胺与所有环糊精均无手性相互作用。沙利度胺仅与β和羧甲基β- cd表现出手性相互作用。基于这些观察,可以得出结论,2位的氧基是手性识别所必需的,而芳香伯胺基则增强了手性识别。采用正交实验设计考察了洗脱液组成、流速和柱温对手性分离的影响。有机改性剂的浓度是影响手性分离的最重要因素。在沙利度胺的情况下,优化参数(β-环糊精为基础的固定相,0.1%醋酸/乙腈95/5 (v/v), 5°C柱温,0.6 ml/min流速)对映体之间的分辨率为1.68±0.02。在以β-环糊精为基础的固定相,0.1%醋酸/乙腈90/10 (v/v), 15℃柱温,0.8 mL/min流速的条件下,泊马度胺的该值为2.70±0.02。利用LC-MS/MS系统的实验条件,可以在小鼠血浆中检测到低至2 ng/mL的两种物质。洗脱序列用对映体标准确定,在两种情况下r -对映体首先被洗脱。所开发的方法适用于上述化合物的手性分离,是生物分析方法发展的良好起点。
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引用次数: 0
In memory of Fodor József 为了纪念福多József
Pub Date : 2018-12-01 DOI: 10.2478/orvtudert-2018-0007
Abram Zoltán
Abstract Fodor József (1843–1901) is the founder of Hungarian hygiene who established the second hygiene department and hygiene institute in the world; he was a member of the Hungarian Academy of Sciences. He lived in the era of great microbiological discoveries, and his rich and multidisciplinary work has opened up new directions and approaches in science. For a short period of time he was professor at the newly established university from Cluj (Kolozsvár), later he had important contributions to the Hungarian public health act of 1876. His entire professional career represents a very special model by the messages left behind. He was proposed for Nobel Prize in medical (biological) sciences, but he suddenly died on 20 March 1901.
福多József(1843-1901)是匈牙利卫生学的奠基人,建立了世界上第二个卫生系和卫生所;他是匈牙利科学院的成员。他生活在微生物学大发现的时代,他丰富的多学科工作为科学开辟了新的方向和方法。他曾在克鲁日新成立的大学(Kolozsvár)短暂担任教授,后来他对1876年匈牙利公共卫生法作出了重要贡献。他的整个职业生涯所留下的信息代表了一个非常特殊的模式。他曾被提名诺贝尔医学(生物)科学奖,但他于1901年3月20日突然去世。
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引用次数: 0
The Appointment as Professor of Zsigmond Purjesz and his Decorations. A Centennial Commemoration 被任命为Zsigmond Purjesz教授和他的勋章。百年纪念
Pub Date : 2018-12-01 DOI: 10.2478/orvtudert-2018-0012
G. György
Abstract Zsigmond Purjesz (1846–1918) was born at Szentes (Hungary), and he became MD at Budapest in 1870. In 1880 he applied for and won by competition the professor’s chair of Internal Medicine at Cluj/Kolozsvár University. He taught there for three decades, and founded a medical school. In 1911 he retired and moved to Budapest. According to his wish, he was buried at Kolozsvár. The first part of our study presents the preliminaries of Purjesz’s appointment to Kolozsvár, based on the documents of the Kolozsvár Medical Faculty kept in the State Archives at Marosvásárhely/Târgu Mureş. Endre Takács from Budapest and Ignác Büchler from Kolozsvár were the other two applicants. A board of three university professors proposed Purjesz on the first, Takács on the second and Büchler on the third place to be appointed as professor. On ministerial proposal the king decided to appoint Purjesz on the 2nd of May, 1880. In the second part of the study we take into account the recognitions and decorations Purjesz got. In 1893 for his activity during the cholera epidemic he was awarded with the Iron-Crown Order, 3rd class. In 1901 he got the title of Court councilor, which implied the form of address “Right Honorable”. In 1906 at the 25th anniversary of his professorship his students and colleagues compiled a memorial volume dedicated to him. In 1910 the Royal City of Kolozsvár declared him Honorary Citizen. Following his retirement his bust made by György Vastagh was unveiled at the courtyard of the hospital. In 1911, the king recognizing his healing and teaching activity raised him to the rank of Hungarian nobility.
Zsigmond Purjesz(1846-1918)出生于匈牙利Szentes, 1870年在布达佩斯成为医学博士。1880年,他申请并通过竞争赢得了克鲁日Kolozsvár大学内科教授的职位。他在那里教了30年书,还创办了一所医学院。1911年,他退休并移居布达佩斯。按照他的遗愿,他被安葬在Kolozsvár。我们研究的第一部分根据保存在Marosvásárhely/ t rgu mureek国家档案馆的Kolozsvár医学院的文件,介绍了Purjesz被任命为Kolozsvár的初步情况。来自布达佩斯的Endre Takács和来自Kolozsvár的Ignác bchler是另外两名申请人。由3名大学教授组成的委员会将普耶兹(1号)、Takács(2号)、布尔切勒(3号)分别推荐为教授。1880年5月2日,根据大臣们的提议,国王决定任命普热什。在研究的第二部分,我们考虑到Purjesz得到的认可和装饰。1893年,由于他在霍乱流行期间的表现,他被授予三级铁冠勋章。1901年,他获得了法院顾问的头衔,这意味着称呼的形式是“尊敬的”。1906年,在他担任教授25周年之际,他的学生和同事为他编写了一本纪念册。1910年,Kolozsvár皇家城市宣布他为荣誉市民。他退休后,György Vastagh为他制作的半身像在医院的院子里揭幕。1911年,国王认可他的治疗和教学活动,将他提升为匈牙利贵族。
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