Pub Date : 2019-01-01DOI: 10.22259/2639-3581.0201001
S. Asadi
HCAA syndrome is a genetic disorder that can lead to gradual loss of intellectual function (mental decline), stroke, and other neurological problems in the middle of adulthood. The mutation in the APP gene, located in the long arm of chromosome 21 as 21q21.3, is the most common genetic cause of HCAA syndrome.
{"title":"The Role of Genetics Mutations in Genes APP, CST3, ITM2B in Inducate Hereditary Cerebral Amyloid Angiopathy Syndrome","authors":"S. Asadi","doi":"10.22259/2639-3581.0201001","DOIUrl":"https://doi.org/10.22259/2639-3581.0201001","url":null,"abstract":"HCAA syndrome is a genetic disorder that can lead to gradual loss of intellectual function (mental decline), stroke, and other neurological problems in the middle of adulthood. The mutation in the APP gene, located in the long arm of chromosome 21 as 21q21.3, is the most common genetic cause of HCAA syndrome.","PeriodicalId":93414,"journal":{"name":"Archives of hematology and blood diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68287557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.22259/2639-3581.0101004
P. Arpan, Cope Jessica, Harris Neil, Zumberg Marc
Dabigatran is a direct oral anticoagulant (DOAC) FDA approved for nonvalvular atrial fibrillation and venous thromboembolism. Benefits of dabigatran when compared to warfarin sodium include a shorter half-life and lack of need for routine monitoring. Recently idarucizumab was FDA approved for dabigatran reversal in the setting of life-threatening bleeding. Idarucizumab binds dabigatran neutralizing its activity. There is limited data regarding efficacy of redosing of idarucizumab as well as clearance of dabigatran in the setting of anuric renal failure. We present a case of a patient on chronic dabigatran for atrial fibrillation who was admitted for septic shock and developed gastrointestinal bleeding, anuric renal failure requiring dialysis for several days; despite two doses of idarucizumab and hemodialysis, the thrombin time remained elevated. Subsequently dabigatran levels returned and confirmed delayed clearance despite these interventions.
{"title":"An Experience with Reversal of Dabigatran with Two Doses of Idarucizumab, Hemodialysis, and Time in the Setting of Anuric Renal Failure and Major Gastrointestinal Bleeding","authors":"P. Arpan, Cope Jessica, Harris Neil, Zumberg Marc","doi":"10.22259/2639-3581.0101004","DOIUrl":"https://doi.org/10.22259/2639-3581.0101004","url":null,"abstract":"Dabigatran is a direct oral anticoagulant (DOAC) FDA approved for nonvalvular atrial fibrillation and venous thromboembolism. Benefits of dabigatran when compared to warfarin sodium include a shorter half-life and lack of need for routine monitoring. Recently idarucizumab was FDA approved for dabigatran reversal in the setting of life-threatening bleeding. Idarucizumab binds dabigatran neutralizing its activity. There is limited data regarding efficacy of redosing of idarucizumab as well as clearance of dabigatran in the setting of anuric renal failure. We present a case of a patient on chronic dabigatran for atrial fibrillation who was admitted for septic shock and developed gastrointestinal bleeding, anuric renal failure requiring dialysis for several days; despite two doses of idarucizumab and hemodialysis, the thrombin time remained elevated. Subsequently dabigatran levels returned and confirmed delayed clearance despite these interventions.","PeriodicalId":93414,"journal":{"name":"Archives of hematology and blood diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68287282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.22259/2639-3581.0101003
Y. Shimazu, M. Toyofuku, M. Masuda, Maiko Inada, M. Nohgawa
{"title":"Heparin-Induced Thrombocytopenia after Severe Injury in an Aged Woman: Using Clinical Scoring System","authors":"Y. Shimazu, M. Toyofuku, M. Masuda, Maiko Inada, M. Nohgawa","doi":"10.22259/2639-3581.0101003","DOIUrl":"https://doi.org/10.22259/2639-3581.0101003","url":null,"abstract":"","PeriodicalId":93414,"journal":{"name":"Archives of hematology and blood diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68287274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.22259/2639-3581.0102002
P. Trivedi, Dharmesh M. Patel, Priya K. Varma, Dhara C. Ladani, Darshita H. Patel, M. Kazi, P. Patel
{"title":"Assessment of Prognostic Significance of Monosomy 7 in Myeloid Malignancies Sole or with Recurrent Chromosomal Abnormalities: An Indian Experience","authors":"P. Trivedi, Dharmesh M. Patel, Priya K. Varma, Dhara C. Ladani, Darshita H. Patel, M. Kazi, P. Patel","doi":"10.22259/2639-3581.0102002","DOIUrl":"https://doi.org/10.22259/2639-3581.0102002","url":null,"abstract":"","PeriodicalId":93414,"journal":{"name":"Archives of hematology and blood diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68287433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.22259/2639-3581.0101006
Onwurah Ow, Okoye Je, Ikegbue Hc, Nwagu Cl, Onyemelue Om, Apakama Ai, Alozie Iu
{"title":"Prevalance of Blood Sugar among Patients Attending Eye Clinic in Guinness Eye Hospital Onitsha -2010 to 2017","authors":"Onwurah Ow, Okoye Je, Ikegbue Hc, Nwagu Cl, Onyemelue Om, Apakama Ai, Alozie Iu","doi":"10.22259/2639-3581.0101006","DOIUrl":"https://doi.org/10.22259/2639-3581.0101006","url":null,"abstract":"","PeriodicalId":93414,"journal":{"name":"Archives of hematology and blood diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68287304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.22259/2639-3581.0102003
Ogbonna Collins Nwabuko, E. Igbigbi, Oseikhuemen Adeboye Ejele
{"title":"Promoting Public Health Campaign on Awareness and Screening for Multiple Myeloma in Nigeria","authors":"Ogbonna Collins Nwabuko, E. Igbigbi, Oseikhuemen Adeboye Ejele","doi":"10.22259/2639-3581.0102003","DOIUrl":"https://doi.org/10.22259/2639-3581.0102003","url":null,"abstract":"","PeriodicalId":93414,"journal":{"name":"Archives of hematology and blood diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68287492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.22259/2639-3581.0102005
K. Cheng
{"title":"A Model of Primary and Secondary Preventions of Lymphedema of Superficial Lymphatic System Using Warm Running Water and Massage","authors":"K. Cheng","doi":"10.22259/2639-3581.0102005","DOIUrl":"https://doi.org/10.22259/2639-3581.0102005","url":null,"abstract":"","PeriodicalId":93414,"journal":{"name":"Archives of hematology and blood diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68287542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.22259/2639-3581.0102001
Pham Thi Viet Huong, Trinh Hong Son
Background: Myeloidsarcoma (MS) is a tumor composed of granulocytic precursor cells occurring in an extramedullary location.MS are rare neoplasms whose knowledge is largely based on case reports. MS is often initially misdiagnosed, the most common alternative diagnoses being lymphoma, undifferentiated cancer, malignant melanoma, extramedullary hematopoiesis and inflammation. Immunohistochemistry and immunophenotying are crucial for the accurate diagnosis of MS. Aim: The aim of this study is to introduce a boy with a very rare clinical case of MS in the diagnosis of myelodysplastic syndrome. Case report: A 9-year-old boy with extramedullary MS has been treated in Pediatric Oncology Department, K hospital from May, 2016 to August, 2016. Method: Retrospectively describe a clinical case. Result: The patient is described smilar to some other cases in literature. He was treated with an Acute Myeloicytic Leukemia conventional chemotherapeutic protocol and discharged. Conclusion: The case is rare in clinical practice. The exact diagnosis was made by immunohistochemistry and immunophenotying. Treatment with systemic chemotherapy was associated with his primary favorable survival outcome.
{"title":"Extramedullary Myeloidsarcoma in Children Presenting with Pancreatic Tumor","authors":"Pham Thi Viet Huong, Trinh Hong Son","doi":"10.22259/2639-3581.0102001","DOIUrl":"https://doi.org/10.22259/2639-3581.0102001","url":null,"abstract":"Background: Myeloidsarcoma (MS) is a tumor composed of granulocytic precursor cells occurring in an extramedullary location.MS are rare neoplasms whose knowledge is largely based on case reports. MS is often initially misdiagnosed, the most common alternative diagnoses being lymphoma, undifferentiated cancer, malignant melanoma, extramedullary hematopoiesis and inflammation. Immunohistochemistry and immunophenotying are crucial for the accurate diagnosis of MS. Aim: The aim of this study is to introduce a boy with a very rare clinical case of MS in the diagnosis of myelodysplastic syndrome. Case report: A 9-year-old boy with extramedullary MS has been treated in Pediatric Oncology Department, K hospital from May, 2016 to August, 2016. Method: Retrospectively describe a clinical case. Result: The patient is described smilar to some other cases in literature. He was treated with an Acute Myeloicytic Leukemia conventional chemotherapeutic protocol and discharged. Conclusion: The case is rare in clinical practice. The exact diagnosis was made by immunohistochemistry and immunophenotying. Treatment with systemic chemotherapy was associated with his primary favorable survival outcome.","PeriodicalId":93414,"journal":{"name":"Archives of hematology and blood diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68287353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.22259/2639-3581.0101001
Í. M. Santos-Pirath, Chandra Chiappin Cardoso, Camila Matiollo, M. Auat, F. Maraslis, S. Maluf, Maria Cláudia Santos da Silva
{"title":"Agressive Acute Myeloid Leukemia with inv(3)(q21q26.2): A Case Report","authors":"Í. M. Santos-Pirath, Chandra Chiappin Cardoso, Camila Matiollo, M. Auat, F. Maraslis, S. Maluf, Maria Cláudia Santos da Silva","doi":"10.22259/2639-3581.0101001","DOIUrl":"https://doi.org/10.22259/2639-3581.0101001","url":null,"abstract":"","PeriodicalId":93414,"journal":{"name":"Archives of hematology and blood diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68287226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.22259/2639-3581.0102004
W. Insiripong, S. Insiripong
{"title":"Primary Pulmonary Lymphoma Presenting as the Lung Abscess: A Case Report","authors":"W. Insiripong, S. Insiripong","doi":"10.22259/2639-3581.0102004","DOIUrl":"https://doi.org/10.22259/2639-3581.0102004","url":null,"abstract":"","PeriodicalId":93414,"journal":{"name":"Archives of hematology and blood diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68287507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：