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The High Importance Role of Epidemiology in Health Management 流行病学在卫生管理中的重要作用
Pub Date : 2021-09-07 DOI: 10.26420/austinjpublichealthepidemiol.2021.1107
M. K, Ahmadzadeh J
Epidemiology is a scientific discipline, sometimes called “the basic science of public health”. According to what it has done in the last 200 years, epidemiology is the science and practice. One of the areas that are less addressed in the literature is the important role of epidemiology in health management. The authors believed that one of the areas that epidemiologists can work is management debate.
流行病学是一门科学学科,有时被称为“公共卫生基础科学”。根据它在过去200年里所做的事情,流行病学是一门科学和实践。文献中较少提及的一个领域是流行病学在健康管理中的重要作用。作者认为流行病学家可以工作的领域之一是管理辩论。
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引用次数: 0
Occurrence of Acute Respiratory Tract Infections among Children Under Five Years Attending Kinango Sub-County Hospital, Kenya 肯尼亚基南戈县附属医院五岁以下儿童急性呼吸道感染的发生率
Pub Date : 2021-07-23 DOI: 10.26420/austinjpublichealthepidemiol.2021.1105
B. Muriithi, Simon Karanja, M. Karama, C. Okoyo, M. Ndemwa, Y. Ichinose, S. Kaneko
Objective: To examine occurrence of Acute Respiratory tract Infections (ARIs) and determine factors associated with ARIs among children under five years attending Kinango Sub-County Hospital. Methods: A cross-sectional survey was conducted among mother-child aged between 0-59 month’s pairs attending outpatient care. Participants were recruited using systematic sampling method. Data was collected using an interviewer-administered structured questionnaire. Descriptive statistics were used to summarize child, parental and environmental characteristics. Factors associated with ARIs were established using binary logistic regression analysis. Odds Ratio (OR), at 95% Confidence Interval (CI) and p <0.05 significant level was used to describe an association between covariates and the outcome variable. Independent factors associated with occurrence of ARIS were determined by stepwise logistic regression. Results: 385 children participated in this study. 228 children (59.2%) presented with ARIs, of which 90.8% were due to acute upper respiratory tract infections. 9.2% of the cases were due to pneumonia. Female gender aOR 3.39 [1.21-9.46], stunting aOR 3.62 [1.04-12.61], high parity aOR 11.45 [2.38-55.09], low maternal education aOR 3.54 [1.10-11.32] and recent hospitalization aOR 8.19 [1.75-38.43] increased the odds of occurrence of an ARI while normal birth weight aOR0.06 [0.01-0.62] was protective of ARIs. Conclusion: A high prevalence of ARIs among children aged below five years was observed in this study, associated with gender, stunting, parity, maternal education, birth weight and recurring hospitalization. Improvements in literacy levels, child nutrition and maternal and child health at large could help to reduce morbidity due to ARIs in this population.
目的:在基南戈县附属医院就诊的五岁以下儿童中,调查急性呼吸道感染(ARIs)的发生情况,并确定与ARIs相关的因素。方法:对门诊就诊的0-59个月的母子进行横断面调查。参与者采用系统抽样方法招募。使用访谈者管理的结构化问卷收集数据。描述性统计用于总结儿童、父母和环境特征。采用二元逻辑回归分析确定ARIs的相关因素。在95%置信区间(CI)和p<0.05显著水平下,使用比值比(OR)来描述协变量和结果变量之间的关联。通过逐步逻辑回归确定与ARIS发生相关的独立因素。结果:385名儿童参与了这项研究。228名儿童(59.2%)出现ARIs,其中90.8%是由于急性上呼吸道感染。9.2%的病例是由肺炎引起的。女性aOR 3.39[1.21-9.46]、发育迟缓aOR 3.62[1.04-12.61]、产次高aOR 11.45[2.38-55.09]、母亲受教育程度低aOR 3.54[1.10-11.32]和近期住院aOR 8.19[1.75-38.43]增加了ARI发生的几率,而正常出生体重aOR 0.06[0.0.01-0.62]对ARI具有保护作用。结论:本研究观察到五岁以下儿童ARIs的高患病率,这与性别、发育迟缓、分娩、母亲教育、出生体重和反复住院有关。提高识字水平、儿童营养和妇幼健康水平有助于降低该人群中ARIs的发病率。
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引用次数: 0
Household Air Pollution Risk on Respiratory Health among Women: A Case Study of Indian District after Clean Fuel Programme 家庭空气污染对女性呼吸系统健康的风险:清洁燃料计划后印度地区的案例研究
Pub Date : 2021-06-30 DOI: 10.26420/austinjpublichealthepidemiol.2021.1104
Bhole V
Objectives: Some of the highest exposures to air pollutants in developing countries occur inside homes where biomass fuels are used for daily cooking. Inhalation of these pollutants may cause deleterious effects on health. Study Design: A total of 450 non-smoking, non-pregnant women aged 15 years and above exposed to domestic smoke from cooking fuels from an early age, working in poorly ventilated kitchen were selected and on investigation presented various health problems. Method: Symptoms were enquired by means of using standard questionnaire adopted from that of the American Thoracic Society (ATS, 1995). Lung function was assessed by the measurement of Forced Vital Capacity (FVC), (FEV1), i.e. volume of air (in liter) that is forcefully exhaled in one second. Using ratio of FEV1 to FVC (FEVI/FVC), expressed as percentage. Results: FVC less than 80% of the predicted was considered as abnormal pulmonary function. Symptoms like chest pain, breathlessness, eye irritation, and blackout were found to be significantly higher in biomass users (P <0.05). Moreover, an increasing trend in the prevalence of symptoms/morbid conditions was observed with increase in exposure. Conclusion Thus women exposed to biomass fuels smoke suffer more from health problems and are at greater risk of respiratory illnesses when compared with other fuel users.
目标:在发展中国家,一些接触空气污染物最多的情况发生在使用生物质燃料进行日常烹饪的家庭内部。吸入这些污染物可能对健康造成有害影响。研究设计:总共选择了450名15岁及以上的不吸烟、未怀孕的妇女,她们从小就暴露于烹饪燃料产生的家庭烟雾中,在通风不良的厨房工作,并在调查中提出了各种健康问题。方法:采用美国胸科协会(ATS, 1995)标准问卷进行症状调查。肺功能通过测量用力肺活量(FVC) (FEV1)来评估,即一秒钟内用力呼出的空气量(单位为升)。使用FEV1与FVC之比(FEVI/FVC),以百分数表示。结果:FVC低于预测值的80%为肺功能异常。胸痛、呼吸困难、眼睛刺激和昏厥等症状在生物质使用者中明显更高(P <0.05)。此外,随着接触的增加,观察到症状/病态状况的流行率呈上升趋势。因此,与其他燃料使用者相比,暴露于生物质燃料烟雾的妇女遭受更多的健康问题和更大的呼吸系统疾病风险。
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引用次数: 0
Electromagnetic Radiations on the Functional Potential of Spermatozoa 精子功能电位的电磁辐射
Pub Date : 2021-06-16 DOI: 10.26420/austinjpublichealthepidemiol.2021.1103
P. Dhasarathan, E. Mg, Athinarayanan Aj, A. Ranjitsingh
The growing exposure to digital communication system and tools leads to radiation toxicity to the users. Unaware of the safety measures even a kid at the age of one starts operating digital gadgets emitting Radio frequencyelectromagnetic radiations. Radiations from mobile phones laptops, note pad, Wi-Fi or other devices are reported to be harmful beyond the permissible limit. So there is a growing concern for the overall health, reproductive, and hormonal functions. Experimental studies were conducted by using a Wi-Fi network active laptop and live spermatozoa. The exposure of sperms to the source of EMF showed that the activity of the live sperms got reduced and mortality was observed depending on the exposure duration and the distance from EMF sources. After 5h of exposure to RF-EMF source the semen quality changed when compared with control. The vitality of sperm in the control was 95±1.0 after 2 hr and it was reduced to 60±1.5 percent at a distance of 1cm and 55±2.2 percent at a distance of 10 cm. After 5 hour exposure, the vitality was reduced to 63±1.86 at 1 cm distance and 70±1.42 at 10 cm distance. The reduction in vitality of sperm after exposure to RF-EMF source for 2 hour was 35% at 1cm and 40% at 10cm distance.
数字通信系统和工具的日益暴露导致了对用户的辐射毒性。在不知道安全措施的情况下,即使是一岁的孩子也开始操作发射射频电磁辐射的数字设备。据报道,来自手机、笔记本电脑、记事本、Wi-Fi或其他设备的辐射有害程度超过了允许的限度。因此,人们越来越关注整体健康、生殖和激素功能。实验研究是通过使用Wi-Fi网络活动笔记本电脑和活精子进行的。精子暴露于EMF源表明,活精子的活性降低,死亡率取决于暴露时间和与EMF源的距离。与对照组相比,RF-EMF源暴露5小时后精液质量发生变化。对照组的精子活力在2小时后为95±1.0,在1厘米处降至60±1.5%,在10厘米处降至55±2.2%。暴露5小时后,在1 cm处降至63±1.86,在10 cm处降至70±1.42。暴露于RF-EMF源2小时后,精子活力在1cm处下降35%,在10cm处下降40%。
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引用次数: 0
A Qualitative Research of Perception Investigations in Caregivers Under the COVID-19 Pandemic 新冠肺炎疫情下护理人员感知调查的定性研究
Pub Date : 2021-06-14 DOI: 10.26420/austinjpublichealthepidemiol.2021.1101
G. X, Bidulescu A
We enthusiastically read the article entitled “The experiences of health-care providers during the COVID-19 crisis in China: a qualitative study” by Liu and colleagues [1]. Although this study highlights the support needed to protect the physical and mental wellness of caregivers in the COVID-19 pandemic, the potential limitations that existed in its qualitative research methods may undermine the accuracy of data collection indicated by our previous work [2,3]. First, the information gleaned from the participants could have been more productive if the authors used focus group as it leverages the power of the group dynamics to encourage back and forth conversation leading to fully exploring and expanding participant’s true feelings, thoughts, and experiences toward the COVID-19 compared to the in-depth interviews [4]. Even though some researchers claim that in-depth interviews (e.g., phone interview) are better to investigate a sensitive subject like the COVID-19 crisis that participants may feel uncomfortable to share their thoughts in front of a group of people, the recent study confirms that 1) sensitive and intimate disclosures are more likely to occur in the focus group; 2) some certain sensitive themes only happen in the focus group; and 3) neither sensitive themes emerged exclusively nor frequently in indepth interviews compared to focus group [5]. Second, ensuring the homogeneity of interest is way more critical than the general heterogeneity like the demographics of the recruited participants [6,7]. Specifically, the desirable combination of interest consensus and common ground with diverse experience is important to generate rich information. However, the perceptions of the COVID-19 pandemic may be different between physicians and nurses based on the duty of these two different professional roles. This is because nurses are more likely to interact with COVID-19 patients directly and more frequently than physicians. Therefore, according to the primary research interest that investigates the experiences of fighting the COVID-19 pandemic, the participants should have been limited to nurses as the frontline caregivers to maintain the homogeneity of interest. Third, considering that all participants were recruited from one local hospital, convenient sampling appears better than snowball sampling as the authors can recruit participants based on their availability and accessibility [8]. This is because scheduling participants at a time when they have more energy may yield richer information data than reaching out to them through phone interviews. These suggested changes in data collection and participant enrollment should be implemented in future qualitative research for the investigation of global pandemic crisis to reach more convincing conclusions.
我们热情地阅读了刘及其同事的题为《新冠肺炎危机期间中国医疗保健提供者的经验:定性研究》的文章[1]。尽管这项研究强调了在新冠肺炎大流行中保护护理人员身心健康所需的支持,但其定性研究方法中存在的潜在局限性可能会破坏我们先前工作所表明的数据收集的准确性[2,3]。首先,如果作者使用焦点小组,从参与者那里收集的信息可能会更有成效,因为与深入访谈相比,焦点小组利用小组动态的力量鼓励来回对话,从而充分探索和扩大参与者对新冠肺炎的真实感受、想法和体验[4]。尽管一些研究人员声称,深入访谈(如电话访谈)更适合调查新冠肺炎危机等敏感主题,参与者在一群人面前分享自己的想法可能会感到不舒服,但最近的研究证实,1)敏感和亲密的披露更可能发生在焦点群体中;2) 某些敏感主题只发生在焦点小组中;3)与焦点小组相比,在深度访谈中既没有专门出现敏感主题,也没有频繁出现敏感主题[5]。其次,确保兴趣的同质性比招募参与者的人口统计等一般异质性更重要[6,7]。具体而言,利益共识和具有不同经验的共同点的理想结合对于生成丰富的信息很重要。然而,基于这两种不同专业角色的职责,医生和护士对新冠肺炎大流行的看法可能有所不同。这是因为护士比医生更有可能直接、更频繁地与新冠肺炎患者互动。因此,根据调查抗击新冠肺炎大流行经验的主要研究兴趣,参与者应仅限于作为一线护理人员的护士,以保持兴趣的同质性。第三,考虑到所有参与者都是从一家当地医院招募的,方便的抽样似乎比滚雪球抽样要好,因为作者可以根据参与者的可用性和可及性招募他们[8]。这是因为,与通过电话采访联系参与者相比,在参与者更有精力的时候安排他们可能会产生更丰富的信息数据。这些建议在数据收集和参与者登记方面的变化应在未来的定性研究中实施,以调查全球大流行危机,从而得出更具说服力的结论。
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引用次数: 0
COVID-19 and Cannabidiol: Results from a Rapid Review COVID-19和大麻二酚:快速回顾的结果
Pub Date : 2021-06-02 DOI: 10.26420/austinjpublichealthepidemiol.2021.1100
M. Holst, D. Nowak, E. Hoch
Background: SARS-CoV2 has caused over 57 million infections and over 1.3 million deaths within 11 months globally (WHO). Internationally, there is an emerging debate about potential benefits of Cannabidiol (CBD) as treatment of COVID-19. Objective: To assess the beneficial and adverse effects of CBD in the treatment of inflammation from the literature. Methods: We systematically searched Cochrane rCOVID-19 study register, CENTRAL (PubMed, Embase, CINAHL, ClinicalTrials.gov and the WHO’s International Clinical Trials Registry Platform) for studies testing CBD as inflammation intervention. All types of studies and populations were considered. All pre-clinical, clinical, and pharmacological outcomes were of interest. Results: Of 18 papers found, 9 were included: Five in vivo animal studies, 3 in vitro studies on human tissues and 1 ongoing randomized clinical trial. Outcomes in 4 in vivo animal studies and 3 human tissue studies were immune response markers, which decreased. In 1 in vivo study the outcome of monocytes was enhanced. One human study is ongoing. There was no information on adverse effects or drug-interaction. Conclusion: There is not enough evidence to support or refute CBD as a repurpose drug to treat inflammation and other symptoms of COVID-19. Clinical trials are needed to test its efficacy and adverse effects.
背景:SARS-CoV2在11个月内已在全球造成5700多万例感染和130多万例死亡(世卫组织)。在国际上,关于大麻二酚(CBD)治疗COVID-19的潜在益处的争论正在兴起。目的:从文献中评价CBD治疗炎症的利弊。方法:我们系统地检索了Cochrane rCOVID-19研究注册中心(PubMed, Embase, CINAHL, ClinicalTrials.gov和WHO的国际临床试验注册平台),以检测CBD作为炎症干预的研究。考虑了所有类型的研究和人群。所有临床前、临床和药理学结果都令人感兴趣。结果:在发现的18篇论文中,纳入了9篇:5篇动物体内研究,3篇人体组织体外研究,1篇正在进行的随机临床试验。4项动物体内研究和3项人体组织研究结果为免疫应答标记物,免疫应答标记物降低。在一项体内研究中,单核细胞的结果得到了增强。一项人体研究正在进行中。没有关于副作用或药物相互作用的信息。结论:没有足够的证据支持或反驳CBD作为治疗COVID-19炎症和其他症状的再用途药物。需要临床试验来检验其疗效和不良反应。
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引用次数: 0
Exercise Habits of Armenians Before and After the Emergence of the COVID-19 Pandemic 亚美尼亚人在COVID-19大流行出现前后的运动习惯
Pub Date : 2021-06-02 DOI: 10.26420/austinjpublichealthepidemiol.2021.1099
S. Dzhugarian, G. Charchoghlyan, Shubrook Jh, Ontario Canada Crossroads North Medical Clinic
The COVID-19 pandemic brought about a variety of changes in people’s lifestyles, including their exercise habits. This study examined changes in exercise habits in individuals of Armenian descent, before and after the emergence of COVID-19, to determine whether significant changes had occurred. Convenience sampling was used by distributing the study throughout Armenian organizations, culturally-relevant social media pages, websites, and email lists. Subjects were required to be at least 18 years of age and of Armenian descent. Survey data was collected between June and August of 2020 from 502 subjects on exercise history, health history, and anthropometry. Disease scores were assigned based on health status. Subjects with higher disease scores were 2.5 and 3.1 times more likely to not exercise prior to and after the pandemic, respectively, compared to subjects with lower disease scores (p<0.001). However, there was no significant difference in change in exercise frequency after the emergence of the pandemic. Additionally, subjects who only exercised in the gym prior to COVID-19 were more likely to decrease their exercise frequency compared to subjects who did not exercise at the gym or did not solely exercise at the gym (p<0.001). Clinicians should place greater emphasis on encouraging Armenian patients with high disease scores to exercise. Armenian patients should also be encouraged to diversify their exercise spaces beyond the gym in order to reduce the risk of decreasing exercise frequency in the event of gym closures due to unforeseen circumstances.
新冠肺炎疫情给人们的生活方式带来了各种各样的变化,包括他们的运动习惯。本研究调查了亚美尼亚后裔在COVID-19出现之前和之后运动习惯的变化,以确定是否发生了重大变化。通过在亚美尼亚组织、与文化相关的社交媒体页面、网站和电子邮件列表中分发研究,使用了方便抽样。调查对象必须年满18岁,是亚美尼亚后裔。调查数据是在2020年6月至8月期间从502名受试者中收集的,包括运动史、健康史和人体测量学。疾病评分是根据健康状况分配的。与疾病得分较低的受试者相比,疾病得分较高的受试者在大流行之前和之后不锻炼的可能性分别高出2.5倍和3.1倍(p<0.001)。然而,在大流行出现后,运动频率的变化没有显着差异。此外,与未在健身房锻炼或仅在健身房锻炼的受试者相比,在COVID-19之前仅在健身房锻炼的受试者更有可能减少锻炼频率(p<0.001)。临床医生应更加重视鼓励疾病得分高的亚美尼亚患者进行锻炼。还应鼓励亚美尼亚病人在健身房以外的地方进行多样化的锻炼,以便在健身房因不可预见的情况而关闭的情况下减少锻炼频率的风险。
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引用次数: 0
Assessing Awareness, Attitude, Knowledge of Evidence-Based Medicine (EBM) Among the Ambulatory Care Physicians and Its Reflection on Their Prescriptions Pattern, 3 Centers at Al-Kharj Hospitals, Saudi Arabia 沙特阿拉伯Al-Kharj医院3个中心门诊医师循证医学意识、态度、知识评估及其对处方模式的反思
Pub Date : 2021-05-27 DOI: 10.26420/austinpublichealth.2021.1014
Almaki Th
Background: Evidence-Based Medicine (EBM) can be defined as “the integration of best research evidence with clinical expertise and patients’ values”. It is the best evidence in making decisions about the care of individual patients. The growing awareness of the limitations of traditional information on clinical decisions led to a shift in medical practice from unsystematic observations from clinical experience, towards evidence-based medicine. The principles of evidence-based medicine have become core concepts of undergraduate, postgraduate, continuing medical education, courses, and workshops offered to health professionals. Irrational prescription being a global problem leading to ineffective or unsafe treatment and that sometimes resulting from the lack of using the EBM. Objective: To assess awareness, attitude, knowledge of EBM among the ambulatory care physicians and its effect in their prescriptions pattern. Methods: A cross-sectional questionnaire study was done to assess the knowledge, attitudes, and practices regarding evidence-based medicine among ambulatory care physicians in 3 hospitals in the Al-Kharj region. In addition, a random sample of ambulatory care prescriptions were collected, then the World Health Organization (WHO) prescription indicators were used to evaluate the physicians prescribing behavior. The prescriptions were collected from the pharmacy department after obtaining approval from the hospital director for each hospital. Result: There was a positive attitude among the ambulatory physicians toward EBM (84%), but there were limit to the basic EBM knowledge (<50 %). Average number of medication encounter was out of the WHO standard value (>1.8%). The Barriers that faced the physicians were included Lack of time (47.7%) and no ready access to EBM (43.1%). The percentage of medications prescribe by generic name was varied between the hospitals, AKFAH (100%), AKMICH (90%) and PSABH (74.05%). Conclusion: In general, there was a positive attitude among the ambulatory physicians toward EBM. The frequent barriers that face the physician to apply EBM included lack of time, no ready access to EBM, and lack of reliable evidence. The attitude and knowledge have a proportion relation to WHO prescribing indicators. It was observed the hospital implement an electronic system were more compliant with prescribing with the generic name.
背景:循证医学(EBM)可以定义为“将最佳研究证据与临床专业知识和患者价值观相结合”。这是决定如何照顾个别病人的最佳证据。人们越来越意识到传统临床决策信息的局限性,导致医疗实践从临床经验的非系统观察转向循证医学。循证医学的原则已经成为本科、研究生、继续医学教育、课程和卫生专业人员研讨会的核心概念。不合理的处方是一个全球性问题,导致无效或不安全的治疗,有时是由于缺乏使用循证医学。目的:了解门诊医师对循证医学的认知、态度、知识及其对处方模式的影响。方法:采用横断面问卷调查法,对Al-Kharj地区3家医院门诊医师的循证医学知识、态度和实践情况进行调查。随机抽取门诊处方,采用世界卫生组织(WHO)处方指标评价门诊医师的处方行为。处方由各医院院长批准后,由药房采集。结果:门诊医师对循证医学持积极态度(84%),但对循证医学基本知识的了解有限(1.8%)。医生面临的障碍包括缺乏时间(47.7%)和没有现成的EBM(43.1%)。各医院、AKFAH(100%)、AKMICH(90%)和PSABH(74.05%)使用通用名开具处方的比例存在差异。结论:门诊医师总体上对循证医学持积极态度。医生在应用循证医学时面临的常见障碍包括缺乏时间、没有现成的循证医学途径以及缺乏可靠的证据。态度和知识与世卫组织处方指标成比例关系。观察发现,实施电子系统的医院更符合使用通用名称的处方。
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引用次数: 0
The Role of the Polish Interdepartmental Commission for the Maximum Admissible Concentrations and Intensities for Agents Harmful to Health in the Working Environment in the Development of Safe Working Conditions 波兰工作环境中有害健康物质最大容许浓度和浓度跨部门委员会在发展安全工作条件方面的作用
Pub Date : 2021-05-20 DOI: 10.26420/austinjpublichealthepidemiol.2021.1098
J. Skowroń, L. Zapór, K. Miranowicz-Dzierżawska
The article discusses the principles of determining the maximum admissible concentration and intensity values for harmful agents present at workplaces as the basic criteria for ensuring safe and hygienic working conditions in Poland and in the European Union. The role of the Interdepartmental Commission for the Maximum Admissible Concentrations and Intensities of Agents Harmful to Health in the Working Environment is presented in this process. The attention was drawn to the relationship between the occupational health and safety legislation and the EC regulations on chemicals, which together provide both employers and the Member States with the necessary data and instruments to work safely with chemicals and to be able to take appropriate actions and risk management measures.
本文讨论了确定工作场所有害物质的最大容许浓度和强度值的原则,这些原则是确保波兰和欧盟安全卫生工作条件的基本标准。在这一过程中介绍了工作环境中有害健康因素的最大容许浓度和强度跨部门委员会的作用。有人提请注意职业健康和安全立法与欧盟委员会化学品条例之间的关系,这两项条例共同为雇主和成员国提供了必要的数据和工具,使其能够安全地使用化学品,并能够采取适当的行动和风险管理措施。
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引用次数: 0
Independent Effects of Metabolic Syndrome and Air Pollution (PM2.5) on Atherosclerosis in Modernizing China 代谢综合征和空气污染(PM2.5)对中国动脉粥样硬化的独立影响
Pub Date : 2021-05-20 DOI: 10.26420/austinjpublichealthepidemiol.2021.1097
Kamsang Woo, Timothy Kcy, P. Chook, Y. J. Hu, Y. H. Yin, Changqing Lin, Lau Kha, Lee Pwa, Celermajer Ds
Background: Air Pollution (AP) and metabolic syndrome (MS) are important global health hazards of the 21st century, in mainland China in particular, and AP has been associated with increased prevalence of cardiovascular diseases, and stroke. Methods: To evaluate the impact of metabolic syndrome on AP-related atherogenesis, 1557 Han Chinese adults (mean age 47.2±11.8 years, male 47%) in Hong Kong, Macau, Pun Yu, Yu County (Shanxi coalmine) and 3-Gorges (Yangtze River) were studied. Cardiovascular risk profiles and metabolic syndrome (IDF criteria) were evaluated. PM2.5 (satellite sensor modeling), and atherosclerotic surrogates, brachial reactivity (FMD) and carotid Intima-media thickness (IMT) (ultrasound), were measured. Results: The yearly PM2.5 concentration ranged from 34.0μg/m³ in Hong Kong to 93.8μg/m³ in 3-Gorges Territories. MS was diagnosed in 340 subjects (21.8%). Smoking status, gender and PM2.5 were similar in the MS cohort versus those without MS. Blood pressures (SBP and DBP), waist circumference, triglycerides and glucose were higher, but high-density lipidcholesterol was lower in the MS cohort, compared to the other subjects. Brachial FMD was significantly lower and carotid IMT significantly higher (0.70±0.13 mm, 95% CI 0.68-0.71 mm vs. 0.63mm±0.14mm, 95% CI 0.62-0.64 mm) in the MS cohort than those without (P<0.0001). On multivariate regression, PM2.5 was not related to MS development, but was significantly related to carotid IMT in both no MS (beta=0.234, P<0.0001) and MS cohorts (beta=0.245, p<0.0001), independent of age, SBP, and waist circumference. There was no direct interaction between PM2.5 and MS. Conclusions: Both AP and MS have independent impacts on atherogenic processes in China, with significant implications for atherosclerosis prevention.
背景:空气污染(AP)和代谢综合征(MS)是21世纪全球重要的健康危害,尤其是在中国大陆,AP与心血管疾病和中风的发病率增加有关。方法:对香港、澳门、番禺、蔚县(山西煤矿)和三峡(长江)1557名汉族成年人(平均年龄47.2±11.8岁,男性47%)进行代谢综合征对AP相关动脉粥样硬化形成的影响研究。评估心血管风险状况和代谢综合征(IDF标准)。测量PM2.5(卫星传感器建模)和动脉粥样硬化替代物、臂反应性(FMD)和颈动脉内膜中膜厚度(IMT)(超声)。结果:香港PM2.5年浓度为34.0μg/m³,三峡地区为93.8μg/m²。340名受试者(21.8%)被诊断为多发性硬化症。与其他受试者相比,多发性痴呆症队列中的吸烟状况、性别和PM2.5与无多发性病变队列相似。血压(SBP和DBP)、腰围、甘油三酯和葡萄糖较高,但高密度脂胆固醇较低。在多发性硬化症队列中,臂FMD显著降低,颈动脉IMT显著升高(0.70±0.13 mm,95%CI 0.68-0.71 mm vs.0.63mm±0.14 mm,95%CI 0.62-0.64 mm)。在多变量回归中,PM2.5与多发性痴呆症的发展无关,但在无多发性病变(β=0.234,P<0.0001)和多发性增生症队列(β=0.245,P<0.0001,与年龄、收缩压和腰围无关。PM2.5和MS之间没有直接的相互作用。结论:AP和MS对中国的动脉粥样硬化过程都有独立的影响,对动脉粥样硬化的预防具有重要意义。
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引用次数: 1
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Austin journal of public health and epidemiology
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