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“Impact on Family Planning Services in Primary Healthcare Facilities in Rural Sindh – Secondary Data Analysis of Pre- and on-going COVID-19 Crisis Period” “对信德省农村初级医疗机构计划生育服务的影响——新冠肺炎危机前和持续期间的二次数据分析”
Pub Date : 2021-12-31 DOI: 10.47363/jmhc/2021(4)169
Nelofer Baig, Altaf H Nizamani
The current COVID-19 pandemic has devastated the improvements in family planning services during the past years. This study assessed the impact of the global pandemic that compromised the provision of family planning services in primary healthcare facilities in Sindh – Pakistan. A retrospective data from District Health Information System (DHIS) before Covid-19 (January – February 2020) and during Covid-19 (March – June 2020) was extracted on the provision of family planning services in primary healthcare facilities in Sindh. The study was conducted to understand the impact of service provision through time-series trend analysis by comparing two health facilities i.e., BHUs and BHU plus facilities on monthly average visits (Jan-Feb average) and differences in percentage change over time on the uptake of short and long-acting family planning methods. The findings suggested that due to lockdown and restrictive mobility, the family planning services have fallen drastically in terms of clients visit the health facility from the onset of the COVID-19 outbreak in the month of March 2020 and remain stagnant till June 2020 as compare to before COVID-19 period. The overall analysis revealed the largest decay in the uptake of family planning methods specifically, pills with 31% and 26% during April 2020 in BHU and BHU plus facilities. On the contrary, uptake of Implants showed 25% and 23% decline in the month of June and May in BHU and BHU plus facilities respectively, compared to the average percentage of the pre-COVID Period. The COVID-19 pandemic has adversely affected the provision of family planning services and steeply decreased the uptake of Pills and Implants in primary healthcare facilities in Sindh. On the contrary, the disruption and decrease in services have provided an opportunity to undertake further research exploration to develop future strategies and policies to combat health challenging situations in such pandemics.
当前的新冠肺炎疫情摧毁了过去几年计划生育服务的改善。这项研究评估了全球疫情对巴基斯坦信德省初级医疗机构计划生育服务提供的影响。从新冠肺炎之前(2020年1月至2月)和新冠肺炎期间(2020年3月至6月)的地区卫生信息系统(DHIS)中提取了信德省初级医疗机构计划生育服务提供的回顾性数据。这项研究是为了通过时间序列趋势分析来了解服务提供的影响,通过比较两个卫生设施,即BHU和BHU+设施对月平均就诊次数(1月至2月平均值)的影响,以及随时间变化的百分比对短期和长期计划生育方法使用的差异。调查结果表明,由于封锁和流动性限制,自2020年3月新冠肺炎疫情爆发以来,计划生育服务的客户访问医疗机构的人数大幅下降,与新冠肺炎之前相比,计划生育一直停滞到2020年6月。总体分析显示,计划生育方法的使用量下降幅度最大,特别是2020年4月,在BHU和BHU+设施中,药丸的使用率分别为31%和26%。相反,与新冠疫情前的平均百分比相比,6月和5月,BHU和BHU+设施的植入物使用量分别下降了25%和23%。新冠肺炎大流行对计划生育服务的提供产生了不利影响,并急剧减少了信德省初级医疗机构对药丸和植入物的使用。相反,服务的中断和减少提供了一个机会,可以进行进一步的研究探索,以制定未来的战略和政策,应对此类流行病中具有挑战性的健康状况。
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引用次数: 0
Efficacy of Syrian Propolis Against Several Bacterial Strains 叙利亚蜂胶对几种菌株的药效研究
Pub Date : 2020-12-31 DOI: 10.47363/JMHC/2020(2)137
Rim M. Harfouch, Rawan Fead, Lubana Hammoud
Propolis is a natural material that can be found in bee honey. It has many medical uses due to its antibacterial activity. In this study we aimed to estimate the antibacterial efficacy of three propolis extracts using three different solvents (Ethanol, Methanol and Ethyl Acetate). We experienced the three extracts on four different strains of bacteria (Klebsiella pneumonia, Ecoli, Pseudomonas aruginosa & Staphylococcus aureus). The results indicated that all the studied propolis extractions do not have any efficacy on Klebsiella neither on Ecoli. The methanolic extract has the greatest effect on Staphylococcus aureus as well as on Pseudomonas aruginosa in contrast of ethanolic and ethyle acetatic extracts which has no efficacy on any of the studied bacterial strains.
蜂胶是一种天然材料,可以在蜂蜜中找到。由于其抗菌活性,它有许多医学用途。在本研究中,我们旨在评估三种蜂胶提取物使用三种不同溶剂(乙醇、甲醇和乙酸乙酯)的抗菌效果。我们对四种不同菌株(肺炎克雷伯菌、大肠杆菌、铜绿假单胞菌和金黄色葡萄球菌)进行了三次提取。结果表明,所有研究的蜂胶提取物对克雷伯菌和大肠杆菌都没有任何疗效。甲醇提取物对金黄色葡萄球菌和铜绿假单胞菌的影响最大,而乙醇和乙酸乙酯提取物对任何研究菌株都没有效果。
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引用次数: 0
Primary Aldosteronism due to a Sub Centimeter Unilateral Adrenal Adenoma 亚厘米级单侧肾上腺腺瘤所致原发性醛固酮增多症
Pub Date : 2020-12-31 DOI: 10.47363/JMHC/2020(2)135
A. Manov, Academic Hospitalist, Tcu Endocrinologist, Amanpreet Kaur
We have described a 44-year old man with past medical history of resistant hypertension on 4-antihypertensive medications including diuretic. He has not been investigated for secondary causes of hypertension despite having elevated blood pressure for 10-years and low normal Potassium level. We started the work up for secondary causes of his HTN and proved by assessing the aldosterone. To plasma renin activity ratio of more than 20 with elevate aldosterone in the blood, sodium load suppression test the existence of primary hyperaldosteronism. The cause as per the CT and MRI of the abdomen and following adrenalvein sampling was found to be right adrenal gland hypersecreting adenoma. We referred the patient for surgery and started treating the patient with mineralocorticoid antagonist with improvement of the blood pressure. Current recommendation about screening and diagnosing primary hyperaldosteronism were discussed as well as the deleterious effect of HTN due to hyperaldosteronism.
我们描述了一名44岁的男性,既往有顽固性高血压病史,服用包括利尿剂在内的4种抗高血压药物。尽管他有10年的高血压和低正常钾水平,但他没有被调查高血压的继发性原因。我们开始研究他HTN的继发性原因,并通过评估醛固酮来证实。血浆肾素活性比大于20伴血中醛固酮升高,钠负荷抑制试验提示原发性高醛固酮血症的存在。经腹部CT及MRI检查及肾上腺静脉取样后发现病因为右肾上腺高分泌性腺瘤。我们转介病人进行手术,并开始用矿皮质激素拮抗剂治疗病人,血压有所改善。讨论了目前关于原发性高醛固酮增多症筛查和诊断的建议,以及高醛固酮增多症引起的HTN的有害作用。
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引用次数: 0
Early Detection Of Epilepsy Based On Synchronization Degree 基于同步度的癫痫早期检测
Pub Date : 2020-12-31 DOI: 10.47363/JMHC/2020(2)133
Y. N. Baakek, S. Debbal
In this work, the synchronization degree is calculated using bi-spectral analysis in order to distinguish between three sets of electroencephalogram signals: normal, pre-ictal, and epileptic seizure cases. The obtained results are compared to six parameters which also extracted from the same analysis; such as the entropies, the mean of bi-spectral amplitude, and weighted center of the bi-spectrum. The obtained results using the proposed algorithm are very satisfactory compared to the other parameters, and show that th
在这项工作中,同步度计算使用双谱分析,以区分三组脑电图信号:正常,孕前和癫痫发作的情况下。将所得结果与从同一分析中提取的6个参数进行了比较;如熵、双谱振幅的均值、双谱的加权中心等。与其他参数相比,该算法得到了令人满意的结果
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引用次数: 0
Huge B-Cell Lymphoma of the Maxillary Sinus: Case Report and Review of the Litterature 上颌窦巨大B细胞淋巴瘤1例报告及文献复习
Pub Date : 2020-12-31 DOI: 10.47363/JMHC/2020(2)139
H. Ngham, Lyoubi Hicham
Primary non-Hodgkin’s lymphoma (NHL) of Paranasal sinus is a rare entity with special characteristics; their locations in the air spaces of the face coming in second row. The prognosis depends on tumor stage and extension into the paranasal sinuses We related the case of a primitive NHL located in the maxillary sinus in a patient of 50 years, invading the entire homolateral nasal cavity. The histopathologic interpretation was B cell lymphoma; the patient received 5 adjuvant chemotherapy treatments according to the CHOP protocol, followed by locoregional external radiotherapy and the evolution was favorable after eighteen months follow-up
原发性副鼻窦非霍奇金淋巴瘤(NHL)是一种罕见的具有特殊特征的实体瘤;它们在第二排的面部的空气空间中的位置。预后取决于肿瘤的分期和向副鼻窦的延伸。我们报道了一例50岁患者的上颌窦原始NHL侵犯整个同侧鼻腔的病例。组织病理学诊断为B细胞淋巴瘤;根据CHOP方案,患者接受了5次辅助化疗,随后进行了局部区域外放疗,随访18个月后进展良好
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引用次数: 0
Coronavirus Disease Pandemic: A Public Health Perspective 冠状病毒病大流行:公共卫生视角
Pub Date : 2020-12-31 DOI: 10.47363/JMHC/2020(2)130
G. Rao
The new novel coronavirus was discovered by a Scottish virologist in London in 1964. As is usual with new discoveries, it seems the article she wrote about this discovery, was rejected by a peer reviewed journal. Dr Almeida wrote to the prestigious journal Nature (Nature 220, 1968), outlining her findings and proposed the name “coronavirus” for the new family of viruses. The name referred to the “crown like” appearance, she first observed on these viruses by electron microscopy. While SARS CoV-2 infection seems to be in control in China (less than 100,000 for a population of over billion), where it originated, the epidemic has moved briskly to the rest of the world. What seemed to be impossible to achieve, - imposing and enforcing strict quarantine of people, -is now a reality in majority of the countries. Success of preventive efforts is related, to how best the key principles of prevention strategies are followed; testing for infection, contact tracing, social distancing, wearing masks, and containment of the infected individuals. In December of 2019, several people in Wuhan, China, developed pneumonia and respiratory failure, like what happened during SARS epidemic of 2003. This virus is easily transmissible by symptomatic as well as asymptomatic individuals. As early as January 2020, SARS CoV-2 virus was found to spread during workshops, company meetings. Hospitals seem to provide a favorable environment for the propagation of coronavirus disease(Covid-19). Long-term care facilities are high-risk settings for infections of respiratory diseases. In the long-term care facilities, majority of the senior citizens, seem to have pre-existing conditions, such as hypertension, obesity, type-2 diabetes or cardiovascular diseases, which puts them at high-risk associated with Covid-19 severity. Several mass gatherings have been associated with explosive outbreaks of Covid-19, including political rallies, protests, sports and entertainment events. The possible role of children in transmission of the coronavirus is still not clear. Several individuals who had recovered from the COVID-19 have tested positive again at a later date, suggesting that the infection has been reactivated. These observations raise question about immunity in covid-19 patients for future infections, as well as the ‘herd immunity’ that we all are hoping for. In the absence of an evidence-based cure, the only choice we have of preventing infection is social distancing, wearing masks where needed, hand washing, contact tracing, and containment. SARS CoV-2 virus spreads through a receptor called angiotensin(ACE 2), which is expressed on many cells including the nasopharyngeal epithelial cells, by attaching to these receptors via its spike like external projections.In view of this observation, there is considerable interest in interventions, that may prevent these interactions including vaccines. The mRNA-1273 Group members have published their preliminary report in NEJM (July 14, 2020)
1964年,一位苏格兰病毒学家在伦敦发现了这种新型冠状病毒。就像通常的新发现一样,她写的关于这一发现的文章似乎被同行评议的期刊拒绝了。阿尔梅达博士写信给著名的《自然》杂志(Nature 220, 1968),概述了她的发现,并建议将这种新病毒命名为“冠状病毒”。这个名字指的是“冠状”的外观,她首先通过电子显微镜观察到这些病毒。虽然SARS - CoV-2感染在其发源地中国(人口超过10亿,但不到10万人)似乎得到了控制,但这一流行病已迅速蔓延到世界其他地区。实施和执行严格的人员隔离,这似乎是不可能实现的,现在在大多数国家已经成为现实。预防工作的成功与如何最好地遵循预防战略的关键原则有关;检测感染、追踪接触者、保持社交距离、戴口罩和隔离感染者。2019年12月,中国武汉的几个人出现了肺炎和呼吸衰竭,就像2003年SARS流行期间发生的那样。这种病毒很容易在有症状和无症状的个体之间传播。早在2020年1月,SARS - CoV-2病毒就被发现在车间、公司会议期间传播。医院似乎为冠状病毒病(Covid-19)的传播提供了有利的环境。长期护理设施是呼吸道疾病感染的高风险场所。在长期护理设施中,大多数老年人似乎已经患有高血压、肥胖、2型糖尿病或心血管疾病等疾病,这使他们处于与Covid-19严重程度相关的高风险状态。包括政治集会、抗议、体育和娱乐活动在内的几次大规模集会与2019冠状病毒病的爆炸性爆发有关。儿童在冠状病毒传播中的可能作用尚不清楚。几名从COVID-19中康复的人在晚些时候再次检测呈阳性,这表明感染已经重新激活。这些观察结果引发了对covid-19患者对未来感染的免疫力以及我们都希望的“群体免疫”的质疑。在缺乏循证治疗的情况下,我们预防感染的唯一选择是保持社交距离、必要时戴口罩、洗手、接触者追踪和控制。SARS CoV-2病毒通过一种叫做血管紧张素(ACE 2)的受体传播,这种受体在包括鼻咽上皮细胞在内的许多细胞上表达,通过其刺突状的外部突起附着在这些受体上。鉴于这一观察结果,人们对包括疫苗在内的可能防止这些相互作用的干预措施非常感兴趣。mRNA-1273小组成员在NEJM(2020年7月14日)上发表了他们的初步报告,成功完成了45名健康成年人的1期研究,他们接受了两种含有稳定灌注SARS CoV-2刺突蛋白的疫苗。疫苗似乎在所有参与者中诱导了SARS - CoV-2免疫反应。这些初步发现支持并鼓励开发这种新型疫苗,以及干扰宿主受体和病毒相互作用的药物
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引用次数: 0
Brine-Shrimp Lethality Bioassay of different extracts of the medicinal plant matricaria (chamomilla) flowers 药用植物洋甘菊花不同提取物的盐水对虾致死性生物测定
Pub Date : 2020-11-13 DOI: 10.21203/rs.3.rs-106834/v1
Amal Ali, S. Ali, Suad Abd Elgadir Abdo EL-Rhman, M. Mohamed, T. Khider
The present study aimed to throw some light on phytochemical constituents of Matricaria (cammomile) flowers. The grinded flowers were extracted successively by petroleum ether (40-60°C), chloroform, 95% ethanol, and ethyl acetate; using soxhlet apparatus respectively. The extracts were concentrated under vacuum (rotatory evaporator).Phytochemical screening of matricaria flowers, were performed using standard methods, showed the presence of alkaloids, flavonoids, terpenoids, saponins, and anthraquinone. The 95% ethanolic crude extract was subjected to column chromatography and nine fractions were collected. Fractions 1-6 have the same Rf value, (using thin layer pre-coated silica gel (0.25cm). were combined and subjected to spectroscopic analysis; infrared spectra showed absorption at 1860, 1637 and 805 cm’ indicating the presence of c=o, c=c, and c-o groups respectively. Ultra violet absorption at 250-283nm assign for the presence of flavonoids, (lit. 250-280). Finally GC/MS spectra performed the presence flavonoids.Crude extracts (ethanol, methanol, petroleum ether, and chloroform) were investigated for antimicrobial activities against four strains of bacteria (Staphylococcus aureus, Escherichia coli, Bacillus sub tills, Pseudomonas aeruginosa, and two fungi: Asperigillus niger, and Candida albican) with disc diffusion method, the diameter of growth inhibition zone ranged 15-22mm.The distilled essential oil (hydro distillation) of matricaria flowers was subjected to GC/MS, a Number of aliphatic compounds were detected e.g. 2, 3 heptadione and 3-hexa none, 2, 5 dimethyl.
本研究旨在为了解Matricaria(cammomile)花的植物化学成分提供一些依据。研磨后的花依次用石油醚(40-60°C)、氯仿、95%乙醇和乙酸乙酯提取;分别使用soxhlet装置。提取液在真空(旋转蒸发器)下浓缩。采用标准方法对基质花进行植物化学筛选,结果表明基质花中存在生物碱、黄酮、萜类、皂苷和蒽醌。对95%乙醇粗提取物进行柱色谱,并收集9个级分。级分1-6具有相同的Rf值(使用薄层预涂硅胶(0.25cm)),合并并进行光谱分析;红外光谱在1860、1637和805厘米处显示吸收,分别表明存在c=o、c=c和c-o基团。250-283nm处的紫外线吸收表明存在黄酮类化合物(插图250-280)。最后用GC/MS对黄酮类化合物的存在进行了分析。采用圆盘扩散法研究了粗提取物(乙醇、甲醇、石油醚和氯仿)对四种细菌(金黄色葡萄球菌、大肠杆菌、枯草芽孢杆菌、铜绿假单胞菌和两种真菌:黑曲霉和白色念珠菌)的抗菌活性,生长抑制区的直径在15-22mm之间。对基质花的蒸馏精油(加氢蒸馏)进行GC/MS,检测到一些脂肪族化合物,如2,3-庚二酮和3-己酮,2,5-二甲基。
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引用次数: 1
Computer Tomographic study of Anatomic Variations of Paranasal Sinuses in Libyan Population and their Clinical Correlation 利比亚人群鼻窦解剖变异及其临床相关性的计算机断层扫描研究
Pub Date : 2020-09-30 DOI: 10.47363/jmhc/2021(3)167
Hawa M R Hawla
Introduction: In the era of Functional Endoscopic Sinus Surgery, precise knowledge of paranasal sinus anatomy and variations are essential for the surgeon. The multi-slice computed tomography is the imaging modality of choice provides accurate evictions of the anatomy, the anatomical variants and the extent of the disease in paranasal sinuses, such a method allowing their accurate identification with high anatomical details. Some of these variants may predispose to sinus diseases or become of high risk for injuries and complication during surgical procedure, therefore, the study of anatomic variants of paranasal sinuses is important in the preoperative endoscopic surgery. Objectives: The purpose of this study is to assess the frequency of anatomic variants and their clinical importance. Materials and methods: This retrospective study was conducted at the Department of Radiology, Benghazi Medical Center, Benghazi, Libya. Data comprised the paranasal sinus computed images of 112 patients (46 males and 66 females) analyzed for the presence of anatomic variants and associated sinus pathology. Results: Our results showed that the most common anatomical variants was deviated nasal septum (60.7%) with slight higher incidence on left side, followed by concha bullosa (22.3%), other variants found were absent frontal sinus (18.8%), Nasal spur (14.3%) , Agger nasi cell (16.1%), Haller cell (5.4%), Onodi cell (2.7%), accessory ostia of maxillary sinuses (10.7%), accessory middle nasal concha (1.8%), paradoxical middle turbinate (1.8%), nasal septum pneumatization (5.4%), Crista galli pneumatization (2.7%), pneumatization of hard palate (1.8%) and pneumatization of clinoid process (6.3%). (53.6%) patients suffered from sinusitis, the results showed that the most common sinus involved was maxillary sinus. Conclusion: Anatomical variations of PNS are quite common. Analysis of every paranasal CT scan obtained for sinusitis for the presence of different anatomic variants is of questionable value unless endoscopic surgery is planned to reduce the risk of intraoperative complications.
引言:在功能性鼻窦手术时代,对鼻窦解剖和变异的精确了解对外科医生来说至关重要。多层计算机断层扫描是一种选择的成像模式,它可以准确地显示鼻窦的解剖结构、解剖变异和疾病程度,这种方法可以准确识别鼻窦的高度解剖细节。其中一些变异可能易患鼻窦疾病,或在手术过程中成为损伤和并发症的高风险,因此,研究鼻窦的解剖变异在术前内镜手术中很重要。目的:本研究的目的是评估解剖变异的频率及其临床重要性。材料和方法:这项回顾性研究在利比亚班加西班加西医疗中心放射科进行。数据包括112名患者(46名男性和66名女性)的鼻窦计算机图像,分析解剖变异和相关鼻窦病理的存在。结果:我们的研究结果显示,最常见的解剖变异是鼻中隔偏曲(60.7%),左侧发病率略高,其次是大疱性鼻甲(22.3%),其他变异有额窦缺失(18.8%)、鼻突(14.3%)、Agger nasi细胞(16.1%)、Haller细胞(5.4%)、Onodi细胞(2.7%)、上颌窦副口(10.7%),副中鼻甲(1.8%)、矛盾中鼻甲、鼻中隔气化(5.4%)、鸡鼻中隔气化、硬腭气化(1.8%)和床突气化(6.3%)。结论:PNS的解剖学变异非常常见。除非计划进行内窥镜手术以降低术中并发症的风险,否则分析鼻窦炎的每一次鼻旁CT扫描是否存在不同的解剖变异具有值得怀疑的价值。
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引用次数: 0
The Teaching of Medical Law as an integral part of Good Pharmacy Practice 医学法学教学是良好药学实践的重要组成部分
Pub Date : 2020-09-30 DOI: 10.47363/jmhc/2021(3)160
George Gregory Buttigieg
Those aspects of medical law pertaining to medical malpractice are not particularly popular with either teaching staff or under/post-graduate students. The situation changes when an individual is facing Court allegations. This article puts forward the concept, as applied to Pharmacy, that Good Practice demands an integral basic assimilation of the teachings of medical law as a concrete way to enhance positive teaching. Furthermore, both the morality and the legality of practice are becoming more or more an indispensable and often compulsory necessity of knowledge for many specialties of healthcare practice. Although the author is a professor of OBGYN, he also teaches medico-legal studies in a leading university department of pharmacy in Rome. His argument is that this must become the rule and not be the exception.
与医疗事故有关的医疗法律的这些方面并不是特别受教学人员或本科生/研究生的欢迎。当个人面临法庭指控时,情况就不同了。本文提出了“良好实践”的概念,并将其应用于药学教学中,即对医学法学教学进行整体的基本同化,作为加强积极教学的具体途径。此外,道德和合法性的做法越来越成为一个不可或缺的,往往是强制性的保健实践的许多专业知识的必要性。虽然作者是妇产科教授,但他也在罗马一所一流大学的药学系教授医学法律研究。他的观点是,这必须成为惯例,而不是例外。
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引用次数: 0
Incidence of Dengue Infection among Febrile Patients in Port Sudan 苏丹港发热病人中登革热感染的发病率
Pub Date : 2020-09-30 DOI: 10.47363/jmhc/2021(3)166
AreegSalih Abdel Aziz Ahmed, Tahani Bashir Mohammeddeen Ahmed
Objective: Aiming to detect dengue virus antibodies in clinically suspicious patients’ serum, contributing to clinical and laboratory advancements in dengue infection management, exploring the association between a clinico-laboratory makeup and Dengue fever, and enhancing the capacity to anticipate, diagnose, and respond to dengue infection. Methods: At Port Sudan 2015, a descriptive cross-sectional hospital-based study was implemented. Six tertiary care hospitals in Port Sudan were included in the report. Patients who attended assigned hospitals with a suspected dengue infection were investigated. Individuals who are at least 9 months old, residency in study area for at least 7 days, pyrexia with unspecified cause for 2-7 days, thrombocytopenia in malaria negative blood film, as well as ages of 9 months and older considerably involved. Gender, age, residency, and clinical symptoms were used as independent variables while dengue patients posing as the dependent variable. Sample size approximation was created based on previous African community studies. To target respondents, a randomized cluster model was used. Information was gathered through direct interview, as well as questionnaire after signed a consent form. 5ml of venous blood withdraw by a professional nurse from each respondent, then examined for hematological indicators of dengue fever using Sysmex XP-300 Automated Hematology Analyzerand dengue specific IgM antibodies using Panbio® Dengue IgM Capture ELISA. Entering data and analysis of the volunteers’ characteristics, the Statistical Package for Social Sciences program (SPSS Inc., Chicago, IL, USA) version 20 was used. Incredibly simple descriptive statistics were used to analyze the laboratory results of the Dengue indicators as well as risk factors. Results: The study involved 83 cases out of 110 that were tested by ELISA at different hospitals in Port Sudan and determined to be diagnosed with the dengue virus.The incidence rate among febrile patients was 75% (68 cases), with DF documented in 80 cases (96%) and DHF in three scenarios (4%). higher prevalence within the (21-30) age category 50/110. (45%).High occurrence rate during July (63 cases) (57%). Fever was the most noticeable clinical feature 79/83(95%, more evident hematological indicators included thrombocytopenia and leucopenia (88%) 97 out of 110 (71%) 78/110 in each event. Most of study subjects were unaware regarding risk factors with exception of transmission mode. Conclusions: Study reported high incidence among suspected febrile participants. Most of patients presented as DF, with greater occurrence among reproductive age group and during July.Thrombocytopenia and leucopenia were more prominent clinical manifestations.With the exception of the mode of transmission, the majority of study respondents were unaware of the risk factors.
目的:旨在检测临床可疑患者血清中的登革热病毒抗体,为登革热感染管理的临床和实验室进展做出贡献,探索临床实验室构成与登革热之间的关系,提高预测、诊断和应对登革热感染的能力。方法:2015年在苏丹港进行了一项描述性的横断面医院研究。报告中包括苏丹港的六家三级护理医院。对在指定医院就诊的疑似登革热感染患者进行了调查。至少9个月大、在研究区居住至少7天、不明原因发热2-7天、疟疾阴性血片中的血小板减少症,以及9个月及以上的患者。性别、年龄、居住地和临床症状被用作自变量,登革热患者被用作因变量。样本量近似值是根据以前的非洲社区研究得出的。为了针对受访者,使用了随机聚类模型。通过直接访谈和签署同意书后的问卷调查收集信息。由一名专业护士从每位受访者中抽取5ml静脉血,然后使用Sysmex XP-300自动血液学分析仪检查登革热的血液学指标,并使用Panbio®登革热IgM捕获ELISA检查登革热特异性IgM抗体。输入数据并分析志愿者的特征,使用社会科学统计包程序(SPSS股份有限公司,芝加哥,伊利诺伊州,美国)第20版。令人难以置信的简单描述性统计被用于分析登革热指标的实验室结果以及风险因素。结果:这项研究涉及110例病例中的83例,这些病例在苏丹港的不同医院进行了ELISA检测,并被诊断为登革热病毒。发热患者的发病率为75%(68例),DF记录为80例(96%),DHF记录为3种情况(4%)。(21-30)年龄组50/110人群中患病率较高。7月发病率高(63例)(57%)。发热是最明显的临床特征79/83(95%),更明显的血液学指标包括血小板减少症和白细胞减少症(88%),110例中有97例(71%)78/110例。除传播方式外,大多数受试者对风险因素一无所知。结论:研究报告了疑似发热参与者的高发病率。大多数患者表现为DF,生殖年龄组和7月发生率更高。血小板减少和白细胞减少是更突出的临床表现。除了传播方式外,大多数研究对象都不知道风险因素。
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