Journal of medicine and healthcare最新文献_第6页

Properties / Characteristics of Antimicrobial Peptides 抗菌肽的性质/特征

Journal of medicine and healthcare

Pub Date : 2022-02-28 DOI: 10.47363/jmhc/2022(4)183

Cristina Gabriela Varga

Antimicrobial peptides (AMPs) are natural antibiotics, synthesized by ribosomes, with an effect on the natural immunity of animal organisms. AMPs differ in composition [sequence and type of amino acids (AAs)] and structure, which contribute to rapid lysis and have a varied spectrum of antimicrobial activity. AMPs are: peptides (Pps) with alpha-helix structure (i.e., cecropins, magainins, mellitin, etc.); cyclic Pps and ring with several cysteine residues (i.e., defensins, protegrins, etc.); Pps rich in one or another AA (i.e., proline arginine-rich PR39, histidine, glycine, etc.). Most AMPs are characterized by hydrophobic and cationic properties, adopt an amphipathic structure (alpha-helix, spiral beta or alpha-helix / spiral beta), which is essential for antimicrobial activity. AMPs have the potential for therapeutic use in medicine. One of the major concerns of life sciences research is finding new ways to enhance the body’s defense against pathogens. One way is to produce drugs based on AMPs. The AMPs are a class of small Pps that have the ability to destroy pathogens of microbial and viral origin. The mechanisms of action are known only partially and for a small number of AMPs, and the toxic action of AMPs is generally considered to be based on the induction by these molecules in the outer membrane of the pathogen of aqueous pores that facilitate nonspecific ion transfer, which ultimately leads to lysis of the target cell.

抗菌肽(Antimicrobial peptides, AMPs)是由核糖体合成的天然抗生素，对动物机体的天然免疫功能起作用。AMPs在组成[氨基酸序列和类型(AAs)]和结构上不同，这有助于快速裂解并具有不同的抗菌活性谱。amp是:具有α -螺旋结构的肽(Pps)(即cecropins, magainins, mellitin等);环状Pps和带有几个半胱氨酸残基的环(即防御素、蛋白蛋白等);富含一种或另一种AA的Pps(即富含脯氨酸精氨酸的PR39、组氨酸、甘氨酸等)。大多数抗菌肽具有疏水性和阳离子性质，采用两亲性结构(α -螺旋、螺旋β或α -螺旋/螺旋β)，这是抗菌活性所必需的。amp在医学上具有治疗用途的潜力。生命科学研究的主要关注点之一是寻找新的方法来增强人体对病原体的防御能力。一种方法是生产基于amp的药物。amp是一类具有破坏微生物和病毒病原体能力的小pp。目前对少量AMPs的作用机制仅知部分，一般认为AMPs的毒性作用是基于这些分子在病原体的水孔外膜诱导非特异性离子转移，最终导致靶细胞的裂解。

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引用次数: 0

Pharmaceutical Evolution of Cohobation Efficiency in Electrohomoeopath 电同源通路中共沸效率的药物进化

Journal of medicine and healthcare

Pub Date : 2022-02-28 DOI: 10.47363/jmhc/2022(4)177

Surendra Pandey

The beginnings of modern scientific ideas are frequently overlooked in today’s scientific education. We were curious about how early philosophers combined the ancient tradition of alchemy with rational thought and reasoning to lay the groundwork for modern scientific disciplines like chemistry and physics. Alchemy, the forerunner of modern chemistry, inspired the development of several scientific principles and experimental procedures that form the cornerstone of empirical science. It has been postulated that Alchemy had philosophical, astronomical, and religious foundations. It went beyond empirical science to grasp the complexities of nature by merging spirituality with experimental observation. Alchemy was obsessed with creating new materials, such as transforming basic metals into valuable metals like gold. In this article, we are going to discuss a scientific approach for the preparation of Electrohomoeopathy remedies via the Cohobation process with the authentication of modern Alchemy. Here we have also discussed Alchemical Cohobation. This article also included a pre-chemistry alchemy technique of multiple distillations, myths, facts, scientific evidence, and philosophy behind tria-prima, the three alchemy primes, and their importance in creating the Electrohomeopathy plant extracts and their potential effects on the human body

现代科学思想的开端在今天的科学教育中经常被忽视。我们很好奇早期哲学家是如何将古代炼金术传统与理性思维和推理相结合，为化学和物理学等现代科学学科奠定基础的。炼金术是现代化学的先驱，它启发了一些科学原理和实验程序的发展，这些原理和程序构成了实证科学的基石。据推测，炼金术有哲学、天文学和宗教基础。它超越了实证科学，通过将精神与实验观察相结合来把握自然的复杂性。炼金术痴迷于创造新材料，比如将基本金属转化为黄金等贵重金属。在这篇文章中，我们将讨论一种科学的方法，以现代炼金术的认证，通过共沸过程来制备电顺势疗法。在这里，我们还讨论了炼金术共合。这篇文章还包括三个炼金术素数tria prima背后的多重提炼、神话、事实、科学证据和哲学的化学前炼金术技术，以及它们在创造电顺势疗法植物提取物中的重要性及其对人体的潜在影响

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引用次数: 0

Clinical, Biological, Scannographic and Prognosis Characteristics of Severe Covid-19 According To the Extent of Lung Lesions on Chest CT Scan 根据胸部CT扫描肺部病变程度分析重症Covid-19的临床、生物学、影像学及预后特征

Journal of medicine and healthcare

Pub Date : 2022-02-28 DOI: 10.47363/jmhc/2022(4)181

Hervéat Ramanandafy

Introduction: COVID-19 caused by SARSCov-2 could be serious and fatal. The objective was to determine the correlation of clinical, biological, CT and prognosis of severe COVID-19 according to the extent of lung lesions on the chest CT scan. Patients and method: This is a retrospective analytical study carried out in the department of pneumology University Hospital of the Joseph Raseta Befelatanana, Antananarivo, Madagascar for a three-month period from March to May 2021. Results: 78 severe COVID-19 cases met the inclusion criteria, for an incidence of 66.7%. The mean age of our patients was 52.81 ± 16.64 years. Age did not differ for the three CT extension groups (p = 0.60). Male gender, dyspnea, C-Reactive protein elevation correlated with the extent of lung damage (p <0.05). On CT scan, the ground glass image and bilateral involvement were also associated with CT extension of lung lesions (p = 0.03, p = 0.04). The prognosis in terms of mortality was worse in severe COVID-19 patients with disease greater than 26%. The overall death was 6.41%. Conclusion: Factors such as male gender, dyspnea, C-reactive protein, frosted glass and bilateral images of severe COVID-19 patients were correlated with the CT extent of lung lesions. Their understandings would make it possible to predict the unfavorable evolution of these lesions on a CT scan, thus reducing mortality.

简介：由SARSCov-2引起的新冠肺炎可能是严重和致命的。目的是根据胸部CT扫描肺部病变的程度，确定重症新冠肺炎的临床、生物学、CT和预后的相关性。患者和方法：这是一项回顾性分析研究，于2021年3月至5月在马达加斯加塔那那利佛Joseph Raseta Befelatanana大学医院呼吸科进行，为期三个月。结果：78例新冠肺炎重症病例符合入选标准，发病率为66.7%，患者平均年龄为52.81±16.64岁。三个CT扩展组的年龄没有差异（p=0.60）。男性、呼吸困难、C-反应蛋白升高与肺损伤程度相关（p<0.05）。在CT扫描上，磨玻璃图像和双侧受累也与肺部病变的CT扩展相关（p=0.03，p=0.04）。疾病超过26%的重症新冠肺炎患者的死亡率预后较差。结论：男性、呼吸困难、C反应蛋白、磨砂玻璃、新冠肺炎重症患者双侧影像等因素与肺部病变的CT程度相关。他们的理解将有可能在CT扫描上预测这些病变的不利演变，从而降低死亡率。

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引用次数: 0

An Analysis of Peripheral Neuropathy Symptom Characteristics in HIV. HIV周围神经病变症状特征分析。

Journal of medicine and healthcare

Pub Date : 2022-01-01 Epub Date: 2022-01-28 DOI: 10.47363/jmhc/2022(4)179

Joyce K Anastasi, Bernadette Capili, Donald J McMahon

Objectives: A gap remains in understanding the association among the symptoms of distal sensory peripheral neuropathy (DSPN) (pain, aching, burning, pins and needles, numbness), comorbidities, and medication use among persons living with People Living with HIV/AIDS (PLWH) with DSPN. This report describes the symptom characteristics associated with prescribed treatment regimens (HIV and non-HIV medications) and comorbidities from a cohort of PLWH experiencing symptoms of DSPN who reside in New York City.

Methods: Our sample (n=353) included PLWH who were 18 years or older, and with painful lower limb (LL) peripheral neuropathy screened for an ongoing clinical trial to reduce DSPN symptoms using acupuncture/moxibustion. The trial participants completed a screening interview where they reported age, gender, race, ethnicity, HIV status, presence of LL DSPN and DSPN symptoms, current medications, and comorbidities.

Results: Of 465 persons screened, 353 provided information for inclusion in this analysis. Seventy-eight percent rated their LL DSPN in the "severe" or "very severe" discomfort/pain range. Nearly half of those were taking prescribed or over-the-counter medication, such as nonnarcotic analgesics, antidepressants, and anticonvulsants, to manage their DSPN discomfort/pain. Despite the use of OTC and or prescription pain relievers, participants reported insufficient symptom relief.

Discussion: Combination Antiretroviral Therapies (CART) effectively control viral load and maintain healthy T-cell levels in individuals with HIV. It has made HIV a chronic disease for many. However, HIV DPSN remains prevalent and has a negative impact on the lives of PLWH. Our findings highlight that, despite the availability and the use of CART, DSPN remains prevalent and not well managed. A critical need exists for the development of effective interventions to manage DSPN symptoms.

目的:在理解远端感觉周围神经病变(DSPN)症状(疼痛、疼痛、灼烧、针刺、麻木)、共病和HIV/AIDS感染者(PLWH) DSPN患者的药物使用之间的关系方面仍然存在差距。本报告描述了与处方治疗方案(艾滋病毒和非艾滋病毒药物)相关的症状特征和居住在纽约市的患有DSPN症状的PLWH队列的合并症。方法:我们的样本(n=353)包括18岁或以上的PLWH，并且患有下肢疼痛(LL)周围神经病变，正在进行一项正在进行的临床试验，以通过针灸减轻DSPN症状。试验参与者完成了筛查访谈，报告了年龄、性别、种族、民族、艾滋病毒状况、LL - DSPN和DSPN症状的存在、目前的药物治疗和合并症。结果:在筛选的465人中，353人提供了纳入本分析的信息。78%的人认为他们的LL DSPN在“严重”或“非常严重”的不适/疼痛范围内。近一半的人服用处方或非处方药物，如非麻醉性镇痛药、抗抑郁药和抗惊厥药，以控制他们的DSPN不适/疼痛。尽管使用OTC和/或处方止痛药，参与者报告症状缓解不足。讨论:联合抗逆转录病毒治疗(CART)有效控制病毒载量和维持健康的t细胞水平的个体HIV。它使艾滋病毒成为许多人的慢性病。然而，艾滋病毒DPSN仍然普遍存在，并对艾滋病患者的生活产生负面影响。我们的研究结果强调，尽管有CART的可用性和使用，但DSPN仍然普遍存在，而且管理不善。目前迫切需要制定有效的干预措施来管理人口和社会问题的症状。

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引用次数: 1

Prevalence of Infections Bronchities Virus at Four Selected Districts (Damot Gale, Sodozuri, Humbo and Kindokoy) In Southern Nations, Nationalities and Peoples 南方国家、民族和人民四个选定地区（Damot Gale、Sodozuri、Humbo和Kindokoy）的感染性支气管炎病毒流行率

Journal of medicine and healthcare

Pub Date : 2021-12-31 DOI: 10.47363/jmhc/2021(3)175

Abebe Garooma Gichile

Infectious bronchitis is an important virial disease affecting poultry production which causes significant economic losses. A cross-sectional study was carried out from November 2019 to January 2020. To estimating the prevalence of infectious bronchitis and determines the risk factors. A total 420 poultry were by a simple random sampling procedure. Data was analyzed using STATA version 11. Chi square test and logistic regression analysis were used to determine the association between prevalence of infectious bronchitis and potential risk factors. From the total 420 poultry examined for infectious bronchitis were found positive. There was significance difference between the risk factors and bronchitis infections. More infectious bronchitis infected poultry were found in kindokoy 90.4%, odd ratio: 0.3 Confidence Interval :0.1-0.7, p = 0.00 than humbo, sodozuri and damotgale. There was high prevalence of infectious bronchitis in gerater than 6 months than less than 3 months and between 3 and 6-month age of poultry. The presence of infectious bronchitis in poultry production might entail morbidity and mortality. Therefore, further detailed molecular epidemiological studies are warranted. Good hygienic and husbandry practices are essential to limit the spread of infection

传染性支气管炎是影响家禽生产的重要病毒性疾病，造成重大经济损失。一项横断面研究于2019年11月至2020年1月进行。目的:估计传染性支气管炎的患病率，确定其危险因素。采用简单随机抽样方法，共采集家禽420只。使用STATA version 11分析数据。采用卡方检验和logistic回归分析确定传染性支气管炎患病率与潜在危险因素之间的关系。共有420只家禽接受传染性支气管炎检查，结果呈阳性。危险因素与支气管炎感染有显著性差异。kindokoy的传染性支气管炎感染率为90.4%，奇比为0.3，置信区间为0.1 ~ 0.7,p = 0.00，高于humbo、sodozuri和damotgale。6月龄以上、3月龄以下和3 ~ 6月龄家禽传染性支气管炎患病率较高。家禽生产中传染性支气管炎的存在可能导致发病率和死亡率。因此，进一步详细的分子流行病学研究是必要的。良好的卫生和饲养做法对限制感染的传播至关重要

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引用次数: 0

Brain Abscess of Dental Origin: A Case Report and Literature Review 牙源性脑脓肿1例报告及文献复习

Journal of medicine and healthcare

Pub Date : 2021-12-31 DOI: 10.47363/jmhc/2021(3)174

Selmi wissal

Introduction: Brain abscess (BA)of dental origin is a rare but potentially life-threatening complication of odontogenic infection that requires immediate neurosurgical attention. It is defined as an encapsulated collection of pus in various areas of the brain. The infectious process spreads from the dental site and occurs in 2 ways: haematogenous route or by contiguity. Treatment should ideally be based on the etiological factor excision, combined with drainage and adjuvant antibiotic therapy. The aim of this article was to report a case of frontal brain abscess of dental origin and to review the literature. Case report: We present the case of a 36-year-old man diagnosed with a brain abscess located in the frontal lobe and caused by a periodontal lesion of the right upper first molar. The final diagnosis was established due to the availability of computed tomography and magnetic resonance imaging. Drainage of the pus combined with extraction of the tooth and antibiotic therapy was followed by an excellent recovery. Clinical and radiological features, treatment and follow-up data were documented. A review of the literature using the PubMed database was performed Conclusion: Oral infections can lead to life-threatening infections, such as brain abscesses. Early detection of this condition through correct diagnosis is essential to give the patient the best treatment; in addition, improving of the oral environment and treating oral infections is highly recommended to limit this serious condition.

牙源性脑脓肿(BA)是一种罕见但可能危及生命的牙源性感染并发症，需要立即进行神经外科治疗。它被定义为大脑不同区域的脓液的封装集合。感染过程从牙齿部位扩散并以两种方式发生:血液途径或邻近途径。理想的治疗应以病因切除为基础，结合引流和辅助抗生素治疗。本文的目的是报告一例牙源性额脑脓肿，并复习文献。病例报告:我们提出的情况下，36岁的男子诊断为脑脓肿位于额叶和引起的牙周病变的右上第一磨牙。最终诊断是由于计算机断层扫描和磁共振成像的可用性。引流脓液，拔牙和抗生素治疗后恢复良好。记录临床和放射学特征、治疗和随访资料。使用PubMed数据库对文献进行了回顾，结论:口腔感染可导致危及生命的感染，如脑脓肿。通过正确诊断及早发现这种疾病对于给予患者最佳治疗至关重要;此外，强烈建议改善口腔环境和治疗口腔感染，以限制这种严重的情况。

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引用次数: 0

The Effects of Facial Exercise on Mental Health, Facial Expression and EEG in Community-Dwelling Older People 面部锻炼对社区老年人心理健康、面部表情和脑电图的影响

Journal of medicine and healthcare

Pub Date : 2021-12-31 DOI: 10.47363/jmhc/2021(4)168

Rumiko Okamoto, Mieko Tanaka, K. Mizukami

Although it is well documented that exercising is good for the mental health and cognitive function as well as the physical condition in elderly people, exercising is difficult in elderly individuals with a low motor function. To develop an exercise program targeting elderly individuals unsuited for whole-body exercises, we assessed the effects of facial exercises on the mental health and mood in healthy elderly people. Community-dwelling older adults (N = 75, age range = 65-87 yrs) were randomly divided into a facial exercises group and a wait-listed control group. A facial exercises program of 30 min was given twice a week for 12 weeks. This program consisted of rhythmic facial movement, muscle stretching, facial yoga, and Tanden breathing. The GHQ-12 for mental health were administered to both groups before and after the 12-week study period. In addition, facial expression and EEG were measured. Fifty-three participants completed the protocol. In the intervention group, the GHQ-12, facial expression, and α wave in frontal lobe improved post-intervention. These results suggest that facial exercises are effective in improving the mental health, facial expression, α wave in frontal lobe of elderly people, and that exercises may be useful as a therapeutic modality in this population.

尽管有充分的证据表明，锻炼对老年人的心理健康、认知功能以及身体状况都有好处，但运动功能低下的老年人很难锻炼。为了制定一项针对不适合全身锻炼的老年人的锻炼计划，我们评估了面部锻炼对健康老年人心理健康和情绪的影响。居住在社区的老年人（N=75，年龄范围=65-87岁）被随机分为面部锻炼组和等待对照组。一个30分钟的面部锻炼计划每周两次，持续12周。这个项目包括有节奏的面部运动、肌肉拉伸、面部瑜伽和Tanden呼吸。在为期12周的研究期间之前和之后，两组均服用GHQ-12精神健康药物。此外，还测量了面部表情和脑电图。五十三名与会者完成了议定书。在干预组中，GHQ-12、面部表情和额叶α波在干预后有所改善。这些结果表明，面部锻炼对改善老年人的心理健康、面部表情和额叶α波是有效的，并且锻炼可能是该人群的一种有用的治疗方式。

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引用次数: 0

Off-Label Use of Medicines in Children Attending a Secondary Healthcare Facility in Federal Capital Territory 在联邦首都地区二级医疗机构就诊的儿童的超说明书用药情况

Journal of medicine and healthcare

Pub Date : 2021-12-31 DOI: 10.47363/jmhc/2021(3)173

Godspower Onavbavba

Before a new drug is approved for marketing in any country, it must have undergone three phases of clinical trials designed to assess its efficacy and safety when used according to an approved recommendation. After a drug has been tested and approved by the regulatory authorities, the drug is usually given a ‘label’ or ‘license’ which is a report describing the drug intended use and dosage. This study aimed at evaluating the use of medicines outside the terms stated in the label. The study was conducted using a data collection form to obtain information from patients’ case file. Data were analysed using Statistical Package for Social Sciences. The case notes of 449 patients were included in the study. The ages of the patients ranged from 4 days to 16 years. Females constituted 51.7% (232) and males 48.3% (217). A total of 1866 drugs were administered to patients, of which 469 (25.13%) were off-label prescriptions. The highest category of off-label drug was indication (45%). This study has revealed a considerable prevalence of off-label use of medicines, there is however need for proper pharmaceutical care to be emplaced in healthcare facilities so as to minimize off-label drug use and prevent adverse effect of drugs as a result of inappropriate use of medicines.

一种新药在任何国家被批准上市之前，必须经过三个阶段的临床试验，以评估其根据批准的建议使用时的有效性和安全性。在药物经过监管机构的测试和批准后，该药物通常会获得一个“标签”或“许可证”，这是一份描述药物预期用途和剂量的报告。本研究旨在评估药品在标签上所述条款之外的使用情况。本研究采用数据收集表格从患者病例档案中获取信息。使用社会科学统计软件包分析数据。研究纳入了449例患者的病例记录。患者年龄从4天到16岁不等。女性占51.7%(232人)，男性占48.3%(217人)。患者共使用药物1866种，其中超说明书处方469种(25.13%)。超说明书用药类别最高的是适应症(45%)。这项研究揭示了药品超说明书使用的相当普遍，然而，需要在卫生保健设施中提供适当的药学护理，以尽量减少超说明书用药，防止因药物使用不当而产生药物不良反应。

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引用次数: 0

Is Suicidality Increased in Covid-19 Pandemic? A Scoping Review and Quality Assessment Covid-19大流行期间自杀率上升了吗?A范围审查和质量评估

Journal of medicine and healthcare

Pub Date : 2021-12-31 DOI: 10.47363/jmhc/2021(4)170

Kimberly Virginin Cruz Correia da Silva

Background: There are emerging concerns that the COVID-19 pandemic may specifically increase suicide. Methods: Scoping Review in the MEDLINE/PubMed, SCOPUS, Web of Science, PsycINFO, Science Direct databases and in the medRxiv, bioRxiv and PsyArXiv preprint servers, using the descriptors “Covid-19”, “coronavirus infection”, “coronavirus”, “2019-nCoV”, “2019 new coronavirus disease”, “SARS-CoV-2”, “Suicide”, “General Public” and “Mental Health”. Results: A total of 62 studies were included in this review, where 10 studies were reported to have been conducted between March and May 2021; 39 in 2020; 4 in 2019; 3 in 2018; 1 in 2015; 2 in 2014; 2 in 2010 and 1 in 2004, all were conducted via online platforms. Limitations: We have interpreted our study findings in the context of the overall significant risk of exposure to suicide in our study population, while recognizing that individual level data of exposure to COVID-19 is a significant confounding variable. Conclusions: Being one of the first reviews in this context, the findings are anticipated to be helpful to predict the possible solutions for reducing the number of suicides in and facilitate further studies on strategies of how to alleviate such a stressful situation in COVID-19.

背景:人们越来越担心COVID-19大流行可能会特别增加自杀率。方法:在MEDLINE/PubMed、SCOPUS、Web of Science、PsycINFO、Science Direct数据库以及medRxiv、bioRxiv和PsyArXiv预印服务器中使用“Covid-19”、“冠状病毒感染”、“冠状病毒”、“2019- ncov”、“2019新型冠状病毒病”、“SARS-CoV-2”、“自杀”、“一般公众”和“心理健康”等描述词进行范围综述。结果:本综述共纳入62项研究，其中10项研究报告于2021年3月至5月期间进行;2020年39个;2019年4个;2018年3个;2015年1人;2014年2次;2010年2次，2004年1次，均通过网络平台进行。局限性:我们在研究人群总体暴露于自杀的重大风险背景下解释了我们的研究结果，同时认识到暴露于COVID-19的个人水平数据是一个重要的混杂变量。结论:作为这方面的首批综述之一，研究结果有望有助于预测减少2019冠状病毒病中自杀人数的可能解决方案，并促进进一步研究如何缓解这种紧张局面的策略。

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引用次数: 0

Chemical Composition and Antibacterial Activity of Extracts of Cymbopogon Citratus (Lemon Grass) and Phyllantus Amarus (Stone Breaker) Leaves 柠檬草和石竹叶提取物的化学成分及抑菌活性研究

Journal of medicine and healthcare

Pub Date : 2021-12-31 DOI: 10.47363/jmhc/2021(3)176

Akintoyese O Alabi

This study described the chemical composition, antioxidant and antibacterial activities of the ethanol and aqueous extracts of fresh and dried leaves of Phyllantus amarus (PA) (Stone breaker), Cymbopogon citratus (CC) (Lemon grass) and combination of stone breaker and lemon grass (PA/CC and DL/DP) using standard methods. The proximate and mineral results showed that both fresh and dried samples of Phyllantus amarus and Cymbopogon citratus were rich in crude fibre (18.53%, 14.65%), ash (16.27%, 2.29%), potassium (95.56 mg/100g, 54.04 mg/100g), calcium (58.57 mg/100g, 7.05 mg/100g), and sodium (15.23 mg/100g, 9.84 mg/100g) respectively. The ability of the extracts to scavenge 2, 2 diphenyl -2- picryl-hydrazyl (DPPH) radical showed that the fresh PA had the highest scavenging activity of 91.12 mg/g, followed (PA/CC) 90.93 mg/g and dried PA (85.61mg/g). The phytochemical composition of the extracts also revealed that they contain high content of cardiac glycoside (11.62 mg/g - 64.81 mg/g), terpenoid (14.56 mg/g - 69.66 mg/g), phenol (14.73 mg/g - 53.93 mg/g), saponin (22.61 mg/g - 30.47mg/g). Dried lemon and dried Phyllantus amarus (DL/DP) was found to be rich in Vitamin A (22.22 mg/g), while the lowest value of Vitamin E (0.36 mg/g) was obtained from fresh lemon grass (0.36mg/g). Antibacterial assay carried out on the two leaves extracts showed that they produced mild antibacterial activity against some foodborne pathogen (Bacillus cereus, Shigella dysenteriae, Escherichia coli, Salmonella spp, Staphylococcus aureus, Pseudomonas spp). with zones of inhibition of 4.3 mm -9.1mm. Further studies should be carried out to investigate the employment of the leaves in production of functional food

采用标准方法研究了毛茛(Phyllantus amarus, PA)(碎石料)、香茅(Cymbopogon citratus, CC)(柠檬草)鲜叶和干叶乙醇提取物和水提取物的化学成分、抗氧化和抗菌活性，以及碎石料和柠檬草(PA/CC和DL/DP)的组合。近因和矿物分析结果表明，鲜、干叶香和香茅分别富含粗纤维(18.53%、14.65%)、灰分(16.27%、2.29%)、钾(95.56 mg/100g、54.04 mg/100g)、钙(58.57 mg/100g、7.05 mg/100g)和钠(15.23 mg/100g、9.84 mg/100g)。对2,2二苯基-2-苦酰基-肼基(DPPH)自由基的清除能力表明，新鲜PA的清除能力最高，为91.12 mg/g，其次为(PA/CC) 90.93 mg/g，干燥PA为85.61mg/g。提取物的植物化学成分分析表明，其心脏苷(11.62 mg/g ~ 64.81 mg/g)、萜类化合物(14.56 mg/g ~ 69.66 mg/g)、酚(14.73 mg/g ~ 53.93 mg/g)、皂苷(22.61 mg/g ~ 30.47mg/g)含量较高。柠檬干和毛竹干(DL/DP)中维生素A含量最高(22.22 mg/g)，而鲜柠檬草中维生素E含量最低(0.36mg/g)。抑菌试验表明，两种提取物对蜡样芽孢杆菌、痢疾志贺氏菌、大肠杆菌、沙门氏菌、金黄色葡萄球菌、假单胞菌等食源性病原菌均有较强的抑菌活性。抑制区为4.3 mm -9.1mm。应开展进一步的研究，以调查在功能性食品生产中的应用

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引用次数: 2