Pub Date : 2021-04-07DOI: 10.4236/OJBD.2021.112004
Chaibou-Yacouba Maimouna, Hamidou Soumana-Diaouga, Amadou Djibrilla-Almoustapha, Moctar Abdoulaye-Maliki, Mansour Sidi-Mahamane, Madeleine Garba-Rah, I. Nafiou, M. Nayama
Pregnancy in a sickle cell patient is a source of maternal and perinatal morbidities. Thromboembolic diseases of which Deep Vein Thrombosis (DVT) is one of the complications. The frequency of the latter is poorly assessed. Very few studies have been done on this topic. We report a case of DVT in a 35-year-old patient with sickle cell SS pregnant with 27SA diagnosed and cared for at the Maternity Issaka Gazobi (MIG) in Niamey. The management was based on low molecular weight heparin combined with preventive measures against sickle cell anemia and a planned cesarean section which led to a favorable maternal and perinatal prognosis.
{"title":"Deep Vein Thrombosis Complicating SS Sickle Cell anemia in Pregnancy: About a Case Diagnosed at the Issaka Gazobi Maternity","authors":"Chaibou-Yacouba Maimouna, Hamidou Soumana-Diaouga, Amadou Djibrilla-Almoustapha, Moctar Abdoulaye-Maliki, Mansour Sidi-Mahamane, Madeleine Garba-Rah, I. Nafiou, M. Nayama","doi":"10.4236/OJBD.2021.112004","DOIUrl":"https://doi.org/10.4236/OJBD.2021.112004","url":null,"abstract":"Pregnancy in a sickle cell patient is a source of maternal and perinatal morbidities. Thromboembolic diseases of which Deep Vein Thrombosis (DVT) is one of the complications. The frequency of the latter is poorly assessed. Very few studies have been done on this topic. We report a case of DVT in a 35-year-old patient with sickle cell SS pregnant with 27SA diagnosed and cared for at the Maternity Issaka Gazobi (MIG) in Niamey. The management was based on low molecular weight heparin combined with preventive measures against sickle cell anemia and a planned cesarean section which led to a favorable maternal and perinatal prognosis.","PeriodicalId":93480,"journal":{"name":"Open journal of blood diseases","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45951253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-07DOI: 10.4236/ojbd.2021.112007
E. P. L. Nanitelamio, S. O. Mokono, C. J. Mbani, Olivia Firmine Galiba Atipo-Tsiba, F. R. Niama, E. Mokondjimobé, D. Moukassa, A. Abena, A. Dokekias
Introduction: Sickle cell disease is a public health problem in the Republic of Congo where the prevalence of sickle cell trait is estimated at 1.25%. The objective of this study is to describe the variations of hematological and biochemical parameters of hemolysis in sickle cell patients in critical and inter-critical periods. Methods: This is a descriptive cross-sectional study including sickle cell patients followed regularly at the National Reference Center for Sickle Cell Disease (CNRDr) from November 2019 to March 2020. A sample of 167 patients (sickle cell subjects in crisis and in steady state as well as control subjects) was randomly selected during the study period. The blood count was performed using a Sysmex-XN 350 automated system and the biochemical parameters were determined using the Cobas e 311 automated system. Statistical analysis was performed with SPSS version 22 software. Results: The study showed that the mean cholesterol level in controls was 4.16 ± 0.77 ul compared with 9.64 ± 4.34 ul in sickle cell crisis subjects. Hb and HCT levels were significantly higher in controls compared with sickle cell subjects in crisis. During crisis, total bilirubin, direct bilirubin, triglycerides, LDH, AST, and CRP were significantly elevated. Hematological parameters such as Hb and HCT were elevated in controls, while the mean WBC value and RET were higher in sickle cell patients in steady state. The mean values of the biochemical parameters were higher in sickle cell patients in steady state. Conclusion: Evaluation of the influence of sickle cell trait on biochemical and hematological parameters showed significant differences between sickle cell and control subjects.
镰状细胞病是刚果共和国的一个公共卫生问题，那里镰状细胞特征的患病率估计为1.25%。本研究的目的是描述镰状细胞患者在临界期和临界间期溶血的血液学和生化参数的变化。方法:这是一项描述性横断面研究，包括镰状细胞患者，于2019年11月至2020年3月在国家镰状细胞病参考中心(CNRDr)定期随访。在研究期间随机抽取167例患者(危重、稳定和对照)。采用Sysmex-XN 350自动化系统进行血液计数，采用Cobas e 311自动化系统测定生化参数。采用SPSS 22软件进行统计分析。结果:研究表明，对照组的平均胆固醇水平为4.16±0.77 ul，而镰状细胞危像组的平均胆固醇水平为9.64±4.34 ul。与危重期镰状细胞患者相比，对照组Hb和HCT水平明显较高。危重期总胆红素、直接胆红素、甘油三酯、LDH、AST、CRP显著升高。血液学参数如Hb和HCT在对照组升高，而平均WBC值和RET在稳定状态下镰状细胞患者较高。稳定状态下镰状细胞患者的生化指标平均值较高。结论:镰状细胞性状对生化和血液学指标的影响评价在镰状细胞与对照组之间存在显著差异。
{"title":"Hematological and Biochemical Profile of Sickle Cell Patients in Critical and Inter-Critical Periods in Brazzaville, Republic of Congo","authors":"E. P. L. Nanitelamio, S. O. Mokono, C. J. Mbani, Olivia Firmine Galiba Atipo-Tsiba, F. R. Niama, E. Mokondjimobé, D. Moukassa, A. Abena, A. Dokekias","doi":"10.4236/ojbd.2021.112007","DOIUrl":"https://doi.org/10.4236/ojbd.2021.112007","url":null,"abstract":"Introduction: Sickle cell disease is a public health problem in \u0000the Republic of Congo where the prevalence of sickle cell trait is estimated at \u00001.25%. The objective of this study is to describe the variations of \u0000hematological and biochemical parameters of hemolysis in sickle cell patients \u0000in critical and inter-critical periods. Methods: This is a descriptive \u0000cross-sectional study including sickle cell patients followed regularly at the \u0000National Reference Center for Sickle Cell Disease (CNRDr) from November 2019 to \u0000March 2020. A sample of 167 patients (sickle cell subjects in crisis and in \u0000steady state as well as control subjects) was randomly selected during the \u0000study period. The blood count was performed using a Sysmex-XN 350 automated \u0000system and the biochemical parameters were determined using the Cobas e 311 \u0000automated system. Statistical analysis was performed with SPSS version 22 \u0000software. Results: The study showed that the mean cholesterol level in \u0000controls was 4.16 ± 0.77 ul compared with 9.64 ± 4.34 ul in sickle cell crisis \u0000subjects. Hb and HCT levels were significantly higher in controls compared with \u0000sickle cell subjects in crisis. During crisis, total bilirubin, direct \u0000bilirubin, triglycerides, LDH, AST, and CRP were significantly elevated. \u0000Hematological parameters such as Hb and HCT were elevated in controls, while \u0000the mean WBC value and RET were higher in sickle cell patients in steady state. \u0000The mean values of the biochemical parameters were higher in sickle cell \u0000patients in steady state. Conclusion: Evaluation of the influence of \u0000sickle cell trait on biochemical and hematological parameters showed \u0000significant differences between sickle cell and control subjects.","PeriodicalId":93480,"journal":{"name":"Open journal of blood diseases","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47856834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To explore the therapeutic effect of autologous blood reinfusion combined with controlled hypotension in surgical spinal fixation during the outbreak of COVID-19. Methods: 30 patients with spinal internal fixation autologous blood transfusion combined with controlled hypotension were selected as the subjects during the epidemic period from December 2019 to June 2020 in our hospital and during the operation, on the basis of routine blood pressure reduction, the American Haemonetice Corporation autologous blood continuous reinfusion system was used to infuse the blood recovered during the operation to the patient through filtration and other procedures. Results: 30 patients had no complications such as fever and hemolysis; And after the operation, the tube was dialed according to the drainage volume, the cervical thoracic and lumbar brace was customized, and the patient walked on the ground for one week; After no abnormalities, the patient was discharged. Intraoperative comparison of white blood cells (WBC), red blood cells (RBC), red blood cell pressure (HCT), hemoglobin (HGB), and coagulation time (PT) of patients with autologous blood before and after transfusion showed statistically significant differences before and after surgery (P < 0.001). Conclusion: During the new coronavirus pneumonia epidemic, the internal fixation of spinal surgery used a recovery machine to collect intraoperative blood for reinfusion. Intraoperative antihypertensive drugs were used to control blood pressure within a certain safe range. The postoperative clinical observation effect was significant and safe; especially at present the clinical significance during the epidemic was significant.
{"title":"Observation on the Efficacy of Autologous Blood Transfusion Combined with Controlled Hypotension in Patients with Spinal Internal Fixation during the Outbreak of New Coronavirus Pneumonia in Western Guangxi (in Guixi)","authors":"Chengkua Huang, Guosheng Su, Zhao Yong, Chunxia Lu, Shengxiong Nong, X. Huang","doi":"10.4236/OJBD.2021.111003","DOIUrl":"https://doi.org/10.4236/OJBD.2021.111003","url":null,"abstract":"Objective: To explore the therapeutic effect of autologous blood reinfusion combined with controlled hypotension in surgical spinal fixation during the outbreak of COVID-19. Methods: 30 patients with spinal internal fixation autologous blood transfusion combined with controlled hypotension were selected as the subjects during the epidemic period from December 2019 to June 2020 in our hospital and during the operation, on the basis of routine blood pressure reduction, the American Haemonetice Corporation autologous blood continuous reinfusion system was used to infuse the blood recovered during the operation to the patient through filtration and other procedures. Results: 30 patients had no complications such as fever and hemolysis; And after the operation, the tube was dialed according to the drainage volume, the cervical thoracic and lumbar brace was customized, and the patient walked on the ground for one week; After no abnormalities, the patient was discharged. Intraoperative comparison of white blood cells (WBC), red blood cells (RBC), red blood cell pressure (HCT), hemoglobin (HGB), and coagulation time (PT) of patients with autologous blood before and after transfusion showed statistically significant differences before and after surgery (P < 0.001). Conclusion: During the new coronavirus pneumonia epidemic, the internal fixation of spinal surgery used a recovery machine to collect intraoperative blood for reinfusion. Intraoperative antihypertensive drugs were used to control blood pressure within a certain safe range. The postoperative clinical observation effect was significant and safe; especially at present the clinical significance during the epidemic was significant.","PeriodicalId":93480,"journal":{"name":"Open journal of blood diseases","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46825552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-20DOI: 10.4236/OJBD.2021.111001
Amadou Djibrilla-Almoustapha, M. Maman-Brah, Moustapha Elhadji-Chefou, M. R. Badé, Amal Al-Azhari, Youssoufa Seydou-Moussa, M. Sani, M. Daou, S. Brah, B. Malam-Abdou
Von Willebrand’s disease was first described in 1926 by Erik Von Willebrand. It is a genetic, constitutional defect of hemostasis that is different from hemophilia. It is classified among the rare diseases whose clinical manifestations are dominated by a hemorrhagic profile, which varies from patient to patient. It is an easily diagnosed disease based on a quantitative and qualitative bioassay of VWF. Treatment is multidisciplinary and is based on well-structured prevention. We report the first case of von Willebrand disease in Niger, diagnosed in the Hematology Department of Niamey’s National Hospital.
{"title":"First Case of Von Willebrand Disease in Niger","authors":"Amadou Djibrilla-Almoustapha, M. Maman-Brah, Moustapha Elhadji-Chefou, M. R. Badé, Amal Al-Azhari, Youssoufa Seydou-Moussa, M. Sani, M. Daou, S. Brah, B. Malam-Abdou","doi":"10.4236/OJBD.2021.111001","DOIUrl":"https://doi.org/10.4236/OJBD.2021.111001","url":null,"abstract":"Von Willebrand’s disease was first described in 1926 by Erik Von Willebrand. It is a genetic, constitutional defect of hemostasis that is different from hemophilia. It is classified among the rare diseases whose clinical manifestations are dominated by a hemorrhagic profile, which varies from patient to patient. It is an easily diagnosed disease based on a quantitative and qualitative bioassay of VWF. Treatment is multidisciplinary and is based on well-structured prevention. We report the first case of von Willebrand disease in Niger, diagnosed in the Hematology Department of Niamey’s National Hospital.","PeriodicalId":93480,"journal":{"name":"Open journal of blood diseases","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49608921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.4236/ojbd.2021.114014
Laure Flora Josiane Kibangou, R. Moyen, Nanikaly Moyen, I. Kocko, L. Ngolet, Ettienne Nguimbi, A. Dokekias
In order to evaluate the seroprevalence of major viral markers, a descriptive study was carried out in homozygous sickle cell transfusion patients at the University Hospital of Brazzaville. The profiles were determined in 51 patients, 32 of whom were male and 19 female, with an age range of 17 to 51 years, admitted to the clinical hematology department of the University Hospital and to the National Reference Center for Sickle Cell Disease. The tests were performed on pre- and post-transfusion blood samples. The following reagents were used: GeenscreenTMultraHIVAg-Ab, MonolisaAg-HBs plus, Monoli-saHCV Ag-Ab Ultrade Bio-Radot for the detection of HIV, HBV and HCV by fourth generation ELISA tests (serological tests). The results showed that the indications for blood transfusion were: acute crises of anemia due to malaria and in some cases of Vaso-Occlusive Crises (VOC) resistance to analgesic treatment. The prevalence rates of the markers before the new transfusion were respectively: HIV: 0%, HBV: 1.96%, HCV: 3.92%. After transfusion, the final seroprevalence rates of the markers are: HIV: 0%, HBV: 5.88%, HCV: 3.92%. The seroconversion rate for HBV was 3.92%. One case of HBV + HCV co-infection (1.96%). Conclusion: Transfusion safety is achieved through good transfusion practices and the qualification of blood donations. Homozygous sickle cell disease, characterized by frequent anemia attacks, requires a guar-antee of efficient transfusion practices in order to limit microbial risks.
{"title":"Prevalence of Virological Markers HIV, HBV and HCV in Homozygous Sickle Cell Patients at Brazzaville University Hospital","authors":"Laure Flora Josiane Kibangou, R. Moyen, Nanikaly Moyen, I. Kocko, L. Ngolet, Ettienne Nguimbi, A. Dokekias","doi":"10.4236/ojbd.2021.114014","DOIUrl":"https://doi.org/10.4236/ojbd.2021.114014","url":null,"abstract":"In order to evaluate the seroprevalence of major viral markers, a descriptive study was carried out in homozygous sickle cell transfusion patients at the University Hospital of Brazzaville. The profiles were determined in 51 patients, 32 of whom were male and 19 female, with an age range of 17 to 51 years, admitted to the clinical hematology department of the University Hospital and to the National Reference Center for Sickle Cell Disease. The tests were performed on pre- and post-transfusion blood samples. The following reagents were used: GeenscreenTMultraHIVAg-Ab, MonolisaAg-HBs plus, Monoli-saHCV Ag-Ab Ultrade Bio-Radot for the detection of HIV, HBV and HCV by fourth generation ELISA tests (serological tests). The results showed that the indications for blood transfusion were: acute crises of anemia due to malaria and in some cases of Vaso-Occlusive Crises (VOC) resistance to analgesic treatment. The prevalence rates of the markers before the new transfusion were respectively: HIV: 0%, HBV: 1.96%, HCV: 3.92%. After transfusion, the final seroprevalence rates of the markers are: HIV: 0%, HBV: 5.88%, HCV: 3.92%. The seroconversion rate for HBV was 3.92%. One case of HBV + HCV co-infection (1.96%). Conclusion: Transfusion safety is achieved through good transfusion practices and the qualification of blood donations. Homozygous sickle cell disease, characterized by frequent anemia attacks, requires a guar-antee of efficient transfusion practices in order to limit microbial risks.","PeriodicalId":93480,"journal":{"name":"Open journal of blood diseases","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70613533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.4236/ojbd.2021.114013
E. Niang, M. Bamba, K. Mamadou, F. Seynabou, Seck Moussa, M. Ababacar, Bousso Elimane, Sarr Khadim, Faye Atoumane, Ndiaye Fatou Samba Diago, N. Moustapha, Diop Saliou
Pub Date : 2021-01-01DOI: 10.4236/ojbd.2021.113009
A. Diallo, S. A. Touré, M. Seck, Mouhamed Keita, E. S. Bousso, B. Faye, S. Diop
{"title":"Acute Panmyelosis with Myelofibrosis: A Rare Subtype of Acute Myeloid Leukemia","authors":"A. Diallo, S. A. Touré, M. Seck, Mouhamed Keita, E. S. Bousso, B. Faye, S. Diop","doi":"10.4236/ojbd.2021.113009","DOIUrl":"https://doi.org/10.4236/ojbd.2021.113009","url":null,"abstract":"","PeriodicalId":93480,"journal":{"name":"Open journal of blood diseases","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70613593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.4236/ojbd.2021.114010
H. H. Mahmoud, Nawal Mahrous Nasef, Dalia Mahmoud Eldewi, Rasha Kamel Fathy Galal
{"title":"Role of Complement Regulatory Proteins (CD55, CD59, and CD35) on Red Blood Cells of β-Thalassaemia Patients","authors":"H. H. Mahmoud, Nawal Mahrous Nasef, Dalia Mahmoud Eldewi, Rasha Kamel Fathy Galal","doi":"10.4236/ojbd.2021.114010","DOIUrl":"https://doi.org/10.4236/ojbd.2021.114010","url":null,"abstract":"","PeriodicalId":93480,"journal":{"name":"Open journal of blood diseases","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70613471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-30DOI: 10.4236/ojbd.2020.104012
N. Kurmanaliev, Baktygul Aisarieva, Iskenderbek Abdiraiimov, Zhainagul Abdirasulova, Zhypargul D. Abdullaeva, M. Karataev, Nurzhigit Kurmanbaev, M. Khan
Objectives: This article is aiming to give an essential informative principle about the development of blood donation activities in Kyrgyzstan. Background: The sequence of blood donation procedure steps before donation, during donation, and after donation was shown and discussed. Methods/Materials: Rhesus factor determination in donors was achieved by “COLICO” method which is based on the use of monoclonal antibodies solution. Results: According to the blood donation activity of donors in Osh, Kyrgyzstan for the 2018 year, it was found that gratuitous donors who donated blood in 6 months were 269, in 9 months were 366, and in 1 year were 499 people. Relative donors who donated blood in 6 months were 3480, in 9 months were 5100, and in 1 year were 6701 people. Active donors donated blood in 6 months were 12, in 9 months were 14 and in 1 year were 17 people. Conclusion: No agglutination was observed in any of the plates for the first blood group; agglutination was observed with anti-A monoclonal antibody solution for the second blood group; agglutination was observed with anti-B monoclonal antibody solution for the third blood group; agglutination was observed with both of anti-A and anti-B monoclonal antibody solutions for the fourth blood group.
{"title":"Development of Blood Donation Activities in Kyrgyzstan and General Implications for Blood Donation","authors":"N. Kurmanaliev, Baktygul Aisarieva, Iskenderbek Abdiraiimov, Zhainagul Abdirasulova, Zhypargul D. Abdullaeva, M. Karataev, Nurzhigit Kurmanbaev, M. Khan","doi":"10.4236/ojbd.2020.104012","DOIUrl":"https://doi.org/10.4236/ojbd.2020.104012","url":null,"abstract":"Objectives: This article is aiming to give an essential informative principle about \u0000the development of blood donation activities in Kyrgyzstan. Background: The \u0000sequence of blood donation procedure steps before donation, during donation, \u0000and after donation was shown and discussed. Methods/Materials: Rhesus factor \u0000determination in donors was achieved by “COLICO” method which is based on the use of \u0000monoclonal antibodies solution. Results: According to the blood \u0000donation activity of donors in Osh, Kyrgyzstan for the 2018 year, it was found \u0000that gratuitous donors who donated blood in 6 months were 269, in 9 months were \u0000366, and in 1 year were 499 people. Relative donors who donated blood in 6 \u0000months were 3480, in 9 months were 5100, and in 1 year were 6701 people. Active \u0000donors donated blood in 6 months were 12, in 9 months were 14 and in 1 year \u0000were 17 people. Conclusion: No agglutination was observed in any of the \u0000plates for the first blood group; agglutination was observed with anti-A \u0000monoclonal antibody solution for the second blood group; agglutination was \u0000observed with anti-B monoclonal antibody solution for the third blood group; \u0000agglutination was observed with both of anti-A and anti-B monoclonal antibody \u0000solutions for the fourth blood group.","PeriodicalId":93480,"journal":{"name":"Open journal of blood diseases","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42702232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-30DOI: 10.4236/ojbd.2020.104015
Yiming Zhao, Rui Zhang, Ling Ge, W. Qian, Fengbo Jin, Ming-zhen Yang
Objective: To detect the positive rate of MyD88 l265p mutation in DLBCL patients, and analyze the correlation between MYD88 L265p mutation and DLBCL prognosis. Methods: In this study, 40 formalin fixed paraffin embedded tissue samples were collected from the pathology department of the Fourth Affiliated Hospital and the First Affiliated Hospital of Anhui Medical University from January 2017 to December 2019. The relationship between MYD88 L265p gene mutation and clinicopathological parameters of DLBCL, such as age, gender, Ann Arbor stage, site, B symptom, NCCN-IPI and IPI score, ECOG PS score, serum ferritin, β2-microglobulin and LDH levels were analyzed. Results: The positive rate of MYD88 L265p was 20% (8/40), 25.0% (6/24) in non GCB and 12.5% (2/16) in GCB. There were no significant differences in age, gender, location, extranodal invasion site, β2-microglobulin, serum ferritin and LDH between wild-type and mutant type of MYD88 gene, but had statistical significance with Han’s classification. MYD88 L265p gene mutation was associated with Ann Arbor stage, NCCN-IPI score and IPI score. Conclusion: MYD88 L265P mutation is closely related to the occurrence, development and prognosis of DLBCL. It is an adverse prognostic factor of DLBCL and may be used for the prognosis evaluation of DLBCL.
{"title":"Expression and Prognosis of MYD88 L265p Mutation in Diffuse Large B-Cell Lymphoma","authors":"Yiming Zhao, Rui Zhang, Ling Ge, W. Qian, Fengbo Jin, Ming-zhen Yang","doi":"10.4236/ojbd.2020.104015","DOIUrl":"https://doi.org/10.4236/ojbd.2020.104015","url":null,"abstract":"Objective: To detect the positive rate of MyD88 l265p mutation in DLBCL patients, and analyze the correlation between MYD88 L265p mutation and DLBCL prognosis. Methods: In this study, 40 formalin fixed paraffin embedded tissue samples were collected from the pathology department of the Fourth Affiliated Hospital and the First Affiliated Hospital of Anhui Medical University from January 2017 to December 2019. The relationship between MYD88 L265p gene mutation and clinicopathological parameters of DLBCL, such as age, gender, Ann Arbor stage, site, B symptom, NCCN-IPI and IPI score, ECOG PS score, serum ferritin, β2-microglobulin and LDH levels were analyzed. Results: The positive rate of MYD88 L265p was 20% (8/40), 25.0% (6/24) in non GCB and 12.5% (2/16) in GCB. There were no significant differences in age, gender, location, extranodal invasion site, β2-microglobulin, serum ferritin and LDH between wild-type and mutant type of MYD88 gene, but had statistical significance with Han’s classification. MYD88 L265p gene mutation was associated with Ann Arbor stage, NCCN-IPI score and IPI score. Conclusion: MYD88 L265P mutation is closely related to the occurrence, development and prognosis of DLBCL. It is an adverse prognostic factor of DLBCL and may be used for the prognosis evaluation of DLBCL.","PeriodicalId":93480,"journal":{"name":"Open journal of blood diseases","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46743035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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