International journal of oncology research最新文献_第3页

Feasibility and value of salivary cortisol sampling to reflect distress in head and neck cancer patients undergoing chemoradiation: A proof-of-concept study. 唾液皮质醇取样反映头颈癌放化疗患者痛苦的可行性和价值:一项概念验证研究

International journal of oncology research

Pub Date : 2022-01-01 Epub Date: 2022-09-12 DOI: 10.23937/2643-4563/1710043

Karishma Chhabria, Mark Bonnen, Joshua Asper, Giselle D Carnaby

Background: Head and neck cancer (HNC) patients undergoing chemo/radiation commonly experience severe and persistent distress associated with treatment related fear and physical side effects such as xerostomia, dysphagia, and dryness of mouth. Cortisol, a stress sensitive hormone, can be easily measured in saliva to reflect biobehavioral responses to such stressors. Unfortunately, it has not been used in this population due to concerns associated with chemoradiation (C/RT) related xerostomia.

Methods: In a proof-of-concept study, we explored the feasibility of collecting salivary cortisol as a marker of fear and distress in HNC patients. Ten HNC subjects undergoing C/RT provided saliva samples for 3 consecutive days across three timepoints (pre-treatment, 3-weeks and 1-month post-treatment) and completed concurrent depression, anxiety and swallowing related fear measures.

Results: Salivary cortisol collection adherence was between 80-60%. It was not impacted by xerostomia. Diurnal cortisol pattern demonstrated dysregulation at pretreatment in 62%, and flattened aberrant slopes continued at 3-weeks and beyond in 50% of subjects.

Conclusions: Our study supports the feasibility and utility of salivary cortisol measurement in HNC patients across the treatment trajectory. Diurnal cortisol measures may be a valuable tool to detect and monitor treatment distress during C/RT in this population.

背景:接受化疗/放疗的头颈癌(HNC)患者通常会经历与治疗相关的恐惧和身体副作用(如口干、吞咽困难和口干)相关的严重和持续的痛苦。皮质醇是一种压力敏感激素，可以很容易地在唾液中测量，以反映对这种压力源的生物行为反应。不幸的是，由于担心与放化疗(C/RT)相关的口干症，它尚未在这一人群中使用。方法:在一项概念验证研究中，我们探讨了收集唾液皮质醇作为HNC患者恐惧和痛苦标志物的可行性。10名接受C/RT治疗的HNC受试者在治疗前、治疗后3周和治疗后1个月三个时间点连续3天提供唾液样本，并同时完成抑郁、焦虑和吞咽相关恐惧测量。结果:唾液皮质醇采集依从性在80-60%之间。它没有受到口干症的影响。62%的受试者在预处理时表现出皮质醇的昼夜模式失调，50%的受试者在3周或更长时间内持续出现平坦的异常斜坡。结论:我们的研究支持了HNC患者在整个治疗过程中唾液皮质醇测量的可行性和实用性。在这一人群中，每日皮质醇测量可能是检测和监测C/RT期间治疗窘迫的有价值的工具。

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引用次数: 0

Nivolumab Induced Acute Pancreatitis and Hyperbilirubinemia 尼沃单抗诱导的急性胰腺炎和高胆红素血症

International journal of oncology research

Pub Date : 2021-12-31 DOI: 10.23937/2643-4563/1710032

Bhatia Unnati, Bajaj Suryansh, Gandhi Darshan, Bajaj Divyansh

Immune checkpoint inhibitors (ICIs) are a novel treatment modality that is quickly becoming the standard of care for the management of a multitude of neoplasms. While immunomodulation is a promising approach, it also carries a risk of immune-related adverse effects (irAEs). Nivolumab is an FDA-approved anti-programmed death-1 (anti-PD-1) checkpoint inhibitor. Nivolumab-induced, immune-related pancreatitis, and hyperbilirubinemia are rare but clinically significant examples of irAEs. Early recognition and prompt management of these conditions are critically important to ensure a better prognosis and prevention of subsequent complications. We report a of

免疫检查点抑制剂(ICIs)是一种新的治疗方式，正迅速成为多种肿瘤治疗的标准治疗方法。虽然免疫调节是一种很有前途的方法，但它也存在免疫相关不良反应(irAEs)的风险。Nivolumab是fda批准的抗程序性死亡-1 (anti-PD-1)检查点抑制剂。尼沃鲁单抗引起的免疫相关性胰腺炎和高胆红素血症是罕见但具有临床意义的irae病例。早期识别和及时处理这些疾病对于确保更好的预后和预防随后的并发症至关重要。我们报告了

引用次数: 0

On the Impact of Premature Termination of Chemotherapy on Relapse of Breast Cancer 过早终止化疗对乳腺癌复发的影响

International journal of oncology research

Pub Date : 2021-03-15 DOI: 10.23937/2643-4563/1710028

Männle Heidrun, M. Karsten, M. Felix, Siebers Jan Willem

Background: Some breast cancer patients receive a recommendation for adjuvant chemotherapy if necessary. In some cases, patients refuse this recommendation. In other cases, they start with chemotherapy, but then discontinue it. The question raised here are the effects of patients’ rejection or premature termination of recommended chemotherapies. Methods: 1916 patients, who received a recommendation for chemotherapy, were analyzed between 1997 and 2017. The analyses included descriptive analyses and Kaplan-Meier survival analyses. Results: A percentage of the patients stopped prematurely (8.4%) or totally refused adjuvant chemotherapy (7.2%). They differed from those who completed the recommended chemotherapy with respect to age (F = 82.483; p < 0.001; ONEWAY-ANOVA), HER2-status (chi2 = 8.290; df = 2; p = 0.016), nodal status (chi2 = 12.785; df = 6; p = 0.047) and type of surgery (breast conserving vs. mastectomy) (chi2 = 6.267; df = 2; p = 0.044). The Kaplan Meier disease-free survival analyses showed significant differences between these groups (Log RankDFS = 21.012; df = 2; p < 0.001). A significant influence on the overall survival was found in the subgroup of hormone-receptor-positive/HER2-negative patients (Log RankHR positive = 4.728; df = 1; p = 0.030). Conclusions: Disease-free and disease-specific overall survival rates worsened in the subgroup of patients with hormone receptor positive/HER2 negative tumors if chemotherapy was stopped prematurely. It seems important to assess the patients’ reasons for discontinuing, to emphasize the importance of chemotherapy and to explicitly encourage patients in this group to see it through to the very end.

背景：一些癌症患者在必要时接受辅助化疗的建议。在某些情况下，患者会拒绝这一建议。在其他情况下，他们从化疗开始，但随后停止。这里提出的问题是患者排斥反应或提前终止推荐的化疗的影响。方法：对1997年至2017年间接受化疗建议的1916名患者进行分析。分析包括描述性分析和Kaplan-Meier生存分析。结果：有一定比例的患者过早停止（8.4%）或完全拒绝辅助化疗（7.2%）。他们与完成推荐化疗的患者在年龄（F=82.483；p<0.001；单因素方差分析）、HER2状态（chi2=8.290；df=2；p=0.016）、，淋巴结状况（chi2=12.785；df=6；p=0.047）和手术类型（保乳与乳房切除术）（chi2=6.267；df=2；p=0.044）。Kaplan-Meier无病生存率分析显示，这些组之间存在显著差异（Log-RankDFS=21.012；df=2，p<0.001）。激素受体阳性/HER2阴性亚组对总生存率有显著影响患者（Log-RankHR阳性=4.728；df=1；p=0.030）。结论：如果过早停止化疗，激素受体阳性/HER2阴性肿瘤患者亚组的无疾病和疾病特异性总生存率会恶化。评估患者停止化疗的原因，强调化疗的重要性，并明确鼓励这一群体的患者坚持到底，这似乎很重要。

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引用次数: 3

Is there an Association between Vaginal Cancer and Genital Prolapse? A Data-Analysis and Review of Literature 阴道癌症和生殖器脱垂之间有联系吗？数据分析与文献综述

International journal of oncology research

Pub Date : 2021-03-13 DOI: 10.23937/2643-4563/1710027

Männle Heidrun, Osorio Birthe, M. Felix, M. Karsten

Purpose: Primary vaginal cancer represents a rare disease. The main risk factor for vaginal carcinoma is a persistent human papillomavirus (HPV) infection. However, chronic mechanic irritation of the vagina, have long been suspected to contribute to the development of vaginal cancer. This study examined to assess possible associations between genital prolapse and the incidence of vaginal cancer. Methods: We conducted a systematic literature search regarding the association between vaginal cancer and genital prolapse, supplemented with our own data set of the Centre for Gynaecological Oncology of the Ortenau Clinic Offenburg. Results: Our case analysis of prolapse-associated vaginal carcinomas corresponds to a large extent with the total collective of vaginal carcinomas. The most frequent histological subtype was squamous cell carcinoma in 90%. The median age of patients with genital prolapse-associated vaginal carcinomas was 75 years (72.9 ± 12.1 years). However prolapse associated vaginal cancers had FIGO stage IV more often than cases of vaginal cancer in general. FIGO stage I was reported as most frequent (39%). FIGO stage IV was the second most frequent stage in prolapse associated cases (25%). Furthermore, the Kaplan-Meier curves are significantly different from unselected vaginal cancer cases. In the prolapse associated cases FIGO stages I and II have a far better disease-free survival; in contrast, the prognosis in the advanced stages is much worse. Conclusion: In addition to the HPV infection, patients with genital prolapsed and those with ongoing systemic corticosteroid therapy or other immunocompromising medications, should be perceived as risk groups and regularly examined.

目的:原发性阴道癌是一种罕见的疾病。阴道癌的主要危险因素是持续的人乳头瘤病毒(HPV)感染。然而，长期以来，阴道的慢性机械性刺激一直被怀疑有助于阴道癌的发展。本研究旨在评估生殖器脱垂与阴道癌发病率之间可能存在的联系。方法:我们对阴道癌与生殖脱垂之间的关系进行了系统的文献检索，并辅以我们自己的奥芬堡Ortenau诊所妇科肿瘤中心的数据集。结果:我们对脱垂相关性阴道癌的病例分析在很大程度上符合阴道癌的总体情况。最常见的组织学亚型为鳞状细胞癌(90%)。脱垂相关阴道癌患者的中位年龄为75岁(72.9±12.1岁)。然而，脱垂相关的阴道癌比一般的阴道癌更常处于FIGO IV期。FIGO I期最常见(39%)。FIGO IV期是脱垂相关病例中第二常见的阶段(25%)。此外，Kaplan-Meier曲线与未选择的阴道癌病例有显著不同。在与脱垂相关的病例中，FIGO I期和II期有更好的无病生存率;相比之下，晚期的预后就差得多。结论:除了HPV感染外，生殖器脱垂患者和正在进行全身皮质类固醇治疗或其他免疫损害药物治疗的患者应被视为危险群体并定期检查。

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引用次数: 0

Destructive Mono-Arthritis Caused by Mycobacterium bovis during Treatment with Pembrolizumab in a Patient Previously Treated with BCG Instillations for Bladder Cancer: A Case Report 一例先前接受BCG灌注治疗膀胱癌症的患者在接受Pembrolizumab治疗期间由牛分枝杆菌引起的破坏性单关节炎：病例报告

International journal of oncology research

Pub Date : 2021-02-10 DOI: 10.23937/2643-4563/1710026

E. Cynthia, Huijts Susanne M, Lubbe Peter AHM van der, Robbrecht Debbie G.J.

Immune checkpoint inhibitor (ICI) treatment is an integral part of second line treatment of patients with urothelial carcinoma (UC) as well as in first line in cisplatin-ineligible patients with PD-L1 positive tumours. A substantial proportion of patients with bladder cancer have been treated with intravesical Mycobacterium bovis BCG in the past. Although it is rare, disseminated infections with Mycobacterium bovis have been described, but not in association with ICI treatment. We herein report a case of destructive monoarthritis caused by Mycobacterium bovis in a patient previously treated with intravesical BCG and a recent initiation of the ICI pembrolizumab in first line for metastatic UC. A culture of synovial fluid from the involved wrist was positive for Mycobacterium bovis. Based on whole genome sequencing based-subtyping, the identified Mycobacterium was shown to be related with the previous BCG instillations. Because of severe complaints and progressive destruction of the patients’ wrist, it was decided to interrupt the pembrolizumab. At that moment, following the seventh cycle of pembrolizumab, evaluation showed a partial disease response. Following systemic treatment with triple combination therapy (Isoniazid, Rifampicin, Ethambutol) and surgery, the complaints of the wrist gradually improved. This is the first report describing a disseminated Mycobacterium bovis infection in a patient treated with an ICI and previous BCG instillations for bladder cancer. This is of relevance, because an increasing number of bladder cancer patients, previously treated with BCG instillations, will be treated with an ICI in advanced disease setting.

免疫检查点抑制剂（ICI）治疗是尿路上皮癌（UC）患者二线治疗以及PD-L1阳性肿瘤顺铂不合格患者一线治疗的组成部分。相当一部分癌症患者过去曾接受过膀胱内牛分枝杆菌BCG治疗。虽然牛分枝杆菌的播散性感染很罕见，但与ICI治疗无关。我们在此报告了一例由牛分枝杆菌引起的破坏性单关节炎患者，该患者先前接受过膀胱内BCG治疗，最近开始在转移性UC的一线使用ICI pembrolizumab。来自受累手腕的滑膜液培养物对牛分枝杆菌呈阳性。基于全基因组测序的分型，鉴定出的分枝杆菌与以前的BCG滴注有关。由于严重的主诉和患者手腕的逐渐损伤，决定中断pembrolizumab治疗。在那一刻，pembrolizumab第七个周期后，评估显示部分疾病反应。经过三重联合治疗（异烟肼、利福平、乙胺丁醇）和手术的全身治疗，手腕的主诉逐渐改善。这是第一份报告，描述了一名接受ICI和先前BCG膀胱癌症滴注治疗的患者的牛分枝杆菌感染。这是相关的，因为越来越多的癌症患者，以前接受过BCG滴注治疗，将在晚期疾病环境中接受ICI治疗。

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引用次数: 0

Breast Metastases from Ovarian Primary: A Rare Entity and Review of Literature 卵巢原发乳腺癌转移:罕见病例及文献回顾

International journal of oncology research

Pub Date : 2021-01-01 DOI: 10.23937/2643-4563/1710030

S. Suresh, Sanjay Bhalgat Bhushan, K. Pravin, Kamal Kishore Lakhera Kamal Kishore Lakhera, Swain Phanindra Kumar, Sharma Raj Govind

Citation: Singh S, Sanjay BB, Kumar P, Lakhera KK, Swain PK, et al. (2021) Breast Metastases from Ovarian Primary: A Rare Entity and Review of Literature. Int J Oncol Res 4:030. doi.org/10.23937/26434563/1710030 Accepted: July 22, 2021: Published: July 24, 2021 Copyright: © 2021 Singh S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

引用本文:Singh S, Sanjay BB, Kumar P, Lakhera KK, Swain PK，等。(2021)卵巢原发乳腺癌转移:一个罕见的实体和文献综述。《国际肿瘤学杂志》4:30。doi.org/10.23937/26434563/1710030接收日期:2021年7月22日发布日期:2021年7月24日版权所有:©2021 Singh S, et al.。这是一篇根据知识共享署名许可协议发布的开放获取文章，该协议允许在任何媒体上不受限制地使用、分发和复制，前提是要注明原作者和来源。

引用次数: 0

Incidentally Found Thyroid Metastases in Head and Neck Squamous Cell Carcinoma - How to Manage It? 头颈部鳞状细胞癌偶然发现甲状腺转移-如何处理?

International journal of oncology research

Pub Date : 2021-01-01 DOI: 10.23937/2643-4563/1710031

R. Gama, P. Oliveira, M. Teixeira, F. Castro, A. Conde

Objectives: The authors aim to review the available literature regarding incidentally found thyroid carcinoma during lymph node dissection for primary head and neck squamous cell carcinoma (SCC), in order to potentially support clinical decision about management of this unexpected entity. Methods: 2 clinical cases are described and a systematic review of the relevant literature on the subject is performed based on Pubmed® database. Results: We reviewed a total of 102 cases. The primary SCCs sites were larynx, oral cavity, and pharynx. Thyroidectomy was performed in 79 cases and thyroid carcinoma was found on histology in 40 cases, mainly papillary subtype. Conclusion: The scenario of thyroid carcinoma incidentally found in head and neck SCC is very unusual. The decision between surgical and conservative management should be made on an individualized basis, considering the biological properties of the thyroid neoplasm itself and, mainly, the prognosis of the primary head and neck disease.

目的:作者旨在回顾有关原发性头颈部鳞状细胞癌(SCC)淋巴结清扫时偶然发现甲状腺癌的现有文献，以潜在地支持对这种意想不到的实体的管理的临床决策。方法:对2例临床病例进行描述，并基于Pubmed®数据库对相关文献进行系统回顾。结果:我们共回顾了102例。SCCs主要发生在喉部、口腔和咽部。甲状腺切除术79例，组织学检查发现甲状腺癌40例，以乳头状亚型为主。结论:头颈部鳞状细胞癌中偶然发现甲状腺癌的情况很少见。选择手术治疗还是保守治疗应根据个体化情况，考虑甲状腺肿瘤本身的生物学特性，主要是考虑原发性头颈部疾病的预后。

引用次数: 0

Hepatosplenic Gamma Delta T-cell Lymphoma Presenting as Progressive Hepatosplenomegaly Highlighted during Pregnancy 妊娠期肝脾γ δ t细胞淋巴瘤表现为进行性肝脾肿大

International journal of oncology research

Pub Date : 2020-06-19 DOI: 10.23937/2643-4563/1710024

A. Hussam, Petkar Mahir, Z. Abdulaziz, A. Mohammed, A. Mohammad, Ahmad Rita, Eldean Mouhammad Sharaf

Hepatosplenic T-cell lymphoma (HSGDTL) is a rare variant of T-cell lymphoma with few reported cases in literature. It usually presents with hepatosplenomegaly and constitutional symptoms, primarily in young to middle aged patients. The prognosis is generally poor, with maximum reported survival periods of 2-3 years. There is a link to immunode-ficiency and some biological treatments. Liver biopsy with flow cytometry is required to confirm the diagnosis. We report a case of gamma delta ( γδ ) HSTCL in a 37-year-old female presenting as progressive hepatosplenomegaly with cytopenia during pregnancy. The patient underwent chemotherapy, splenectomy and bone marrow transplant and is in remission 10 months after the diagnosis. As far as we are aware, this is the first case of γδ HSGDTL reported in the Middle East and the second documented case of HSGDTL that highlighted during pregnancy.

肝脾t细胞淋巴瘤(HSGDTL)是一种罕见的t细胞淋巴瘤，文献报道病例很少。它通常表现为肝脾肿大和体质症状，主要见于中青年患者。预后一般较差，据报道最长生存期为2-3年。这与免疫缺陷和一些生物治疗有关。需要肝活检和流式细胞术来确认诊断。我们报告一个37岁女性的γδ (γδ) HSTCL病例，在怀孕期间表现为进行性肝脾肿大伴细胞减少。患者接受了化疗、脾切除和骨髓移植，确诊10个月后病情缓解。据我们所知，这是中东地区报道的第一例γδ HSGDTL病例，也是第二例记录的妊娠期HSGDTL病例。

引用次数: 0

Supporting the Supporters: What are the Unmet Needs and Quality of Life of Caregivers of Cancer Patients in Singapore? 支持支持者：新加坡癌症患者护理人员的未满足需求和生活质量是什么？

International journal of oncology research

Pub Date : 2020-05-22 DOI: 10.23937/2643-4563/1710023

Chua Gek Phin, Ng Quan Sing, T. H. Khoon, O. W. Sze

Background: Caregivers of cancer patients may assume diverse responsibilities during the patient’s cancer trajectory, providing physical assistance, emotional and financial support. These responsibilities can be highly demanding, emotionally stressful and financially draining and can impact on the caregivers’ quality of life (QOL). This study aims to determine the unmet needs of caregivers of cancer patients in Singapore and establish if the unmet needs are associated with their QOL in order to guide practice. Methods: A cross-sectional survey was conducted with 986 caregivers of cancer patients. Determinants of caregivers’ unmet needs and QOL were assessed by the Support Person Unmet Needs Survey (SPUNS-SF) and the Singapore version of the Caregiver Quality of Life Index-Cancer (CQOLC-S25). Results: The mean overall score of unmet needs was 20.98 ± 20.1. The top 3 items with the highest mean score of unmet needs were all from the “Future” domain viz. “dealing with worry about cancer getting worse” (1.50 ± 1.4), “dealing with not knowing what lies in the future” (1.43 ± 1.3) and “dealing with worry about cancer coming back” (1.20 ± 1.3). Caregivers who were younger, the primary caregivers, caregivers who provided financial assistance to the patients they cared for, caregivers whose health status were made worse by caregiving activities, caregivers who were taking care of female patients, lung cancer patients and patients on palliative care had significantly higher mean overall score of unmet needs. The mean overall QOL score was 71.34 ± 17.5. The overall QOL scores were negatively correlated with the overall scores of unmet needs. There were significant negative correlation between QOL and all domains of unmet needs. Conclusion: Our results demonstrate that caregivers of cancer have many unmet needs and these unmet needs have a significant negative effect on their QOL. Thus, addressing their unmet needs is critical to enhance their coping skills and ultimately their QOL.

背景：癌症患者的护理人员可能在患者癌症发展过程中承担不同的责任，提供身体帮助、情感和经济支持。这些责任可能要求很高，情绪紧张，经济枯竭，并可能影响照顾者的生活质量。本研究旨在确定新加坡癌症患者护理人员的未满足需求，并确定未满足需求是否与他们的生活质量相关，以指导实践。方法：对986名癌症患者的护理人员进行横断面调查。护理人员未满足的需求和生活质量的决定因素通过支持人员未满足需求调查（SPUN-SF）和新加坡版护理人员生活质量指数-癌症（CQOLC-S25）进行评估。结果：未满足需求的平均总分为20.98±20.1。未满足需求平均得分最高的前三项均来自“未来”领域，即“应对对癌症恶化的担忧”（1.50±1.4）、“应对不知道未来会发生什么”（1.43±1.3）和“应对对癌症卷土重来的担忧”，为其护理的患者提供经济援助的护理人员、因护理活动而使健康状况恶化的护理人员，照顾女性患者的护理人员以及癌症患者和接受姑息治疗的患者的未满足需求的平均总分显著更高。平均总生活质量评分为71.34±17.5。生活质量总分与未满足需求总分呈负相关。生活质量与未满足需求的所有领域之间存在显著的负相关。结论：我们的研究结果表明，癌症护理人员有许多未满足的需求，这些未满足的需要对他们的生活质量有显著的负面影响。因此，解决他们未满足的需求对于提高他们的应对技能并最终提高他们的生活质量至关重要。

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引用次数: 0

Concerns and Quality of Life of Cancer Survivors across the Survivorship Trajectory 癌症幸存者对生存轨迹的关注与生活质量

International journal of oncology research

Pub Date : 2020-04-25 DOI: 10.23937/2643-4563/1710021

Chua Gek Phin, Ng Quan Sing, T. H. Khoon, O. W. Sze

Background The aim of this study is to determine the main concerns of survivors at various stages of the cancer survivorship of the cancer survivorship trajectory and to assess whether these concerns have any effect on their quality of life (QOL). The overall goal was to use the insights from the study to guide practice on patient care. Methods A cross-sectional survey of 1107 cancer survivors diagnosed with colorectal, breast, lung, gynaecological, prostate or liver cancers from a cancer centre in Singapore. Eligible patients self-completed a questionnaire adapted from the Mayo Clinic Cancer Centre’s Cancer Survivors Survey of Needs. Results The top 5 concerns among all survivors were cancer treatment and recurrence risk (51%), followed by long-term treatment effects (49%), fear of recurrence (47%), financial concerns (37%) and fatigue (37%). Cancer treatment and recurrence risk, long-term treatment effects and fear of recurrence were amongst the top concerns across the survivorship trajectory. Mean QOL was 7.3 on a scale of 0 – 10. Completed treatment patients had higher QOL score than the newly diagnosed and on treatment patients and the patients dealing with recurrence or second cancer patients. Predictors for QOL included the economic status and housing type of patients and whether patients were concerned with pain and fatigue Conclusion This study confirms that cancer survivors in Singapore face multiple challenges and had various concerns at various stages of cancer survivorship, some of which negatively affect their QOL It is critical to design patient care delivery that appropriately address the various concerns of cancer survivors in order for them to cope and improve their QOL.

背景本研究的目的是确定癌症幸存者在癌症生存轨迹的不同阶段的主要关注点，并评估这些关注点是否对他们的生活质量（QOL）有任何影响。总体目标是利用研究的见解来指导患者护理实践。方法对来自新加坡癌症中心的1107名被诊断为结直肠癌、乳腺癌、肺癌、妇科癌、前列腺癌或肝癌的癌症幸存者进行横断面调查。符合条件的患者自我填写了一份问卷，该问卷改编自癌症梅奥诊所中心的癌症幸存者需求调查。结果所有幸存者最关心的5个问题是癌症治疗和复发风险（51%），其次是长期治疗效果（49%）、对复发的恐惧（47%）、经济问题（37%）和疲劳（37%）。癌症治疗和复发风险、长期治疗效果和对复发的恐惧是整个生存轨迹中最令人担忧的问题。平均生活质量为7.3，评分范围为0-10。完成治疗的患者的生活质量得分高于新诊断和治疗中的患者以及复发或继发癌症患者。生活质量的预测因素包括患者的经济状况和住房类型以及患者是否关心疼痛和疲劳，其中一些会对他们的生活质量产生负面影响设计适当解决癌症幸存者各种问题的患者护理服务至关重要，以便他们应对并改善生活质量。

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引用次数: 1