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FORMULATION AND EVALUATION OF LEVOCETIRIZINE TOPICAL GEL 左西替利嗪外用凝胶的制备及评价
Pub Date : 2022-01-01 DOI: 10.21276/bpr.2022.12.2
C. P.
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引用次数: 0
INVESTIGATING SYNERGISTIC ACTIVITY OF METHANOLIC EXTRACT OF CURCUMA LONGA AND MORINGA OLIFERA FOR IN VITRO ANTIOXIDANT AND ANTIBACTERIAL ACTIVITIES 探讨姜黄和辣木甲醇提取物对体外抗氧化和抗菌活性的协同作用
Pub Date : 2022-01-01 DOI: 10.21276/bpr.2022.12.3
T. S, Omini M, B. A, B. P., L. K, P. S.
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引用次数: 1
ORAL ANTIVIRAL MEDICINES FOR COVID-19 口服COVID-19抗病毒药物
Pub Date : 2022-01-01 DOI: 10.21276/bpr.2022.12.1
Colon Kr, Dahiya S
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引用次数: 0
MAGNETIC NANOLIPOSOMES: A REVIEW ON PREPARATION AND CHARACTERIZATION METHODS 磁性纳米脂质体的制备及表征方法综述
Pub Date : 2021-01-01 DOI: 10.21276/bpr.2021.11.3
P. Selvamani, Venkata Krishnan Par, Rosi Rajamanickam, S. Latha
Magnetic nanoliposomes are versatile nanocarriers for targeted drug delivery. These liposomes can enhance the efficacy of bioactive compounds by improving pharmacokinetic parameters. Chemical ingredients of magnetic nanoliposomes include ferrofluid, cholesterol and phospholipid molecules. The preparation of magnetic nanoliposomes involves two steps viz. synthesis of magnetic nanoparticles and then combination with prepared nanoliposomes. The magnetic nanoliposomes are synthesized by various chemical methods including co-precipitation, thermal decomposition, microemulsion and hydrothermal synthesis. The nanoliposomes are prepared by sonication, extrusion, micro-fluidization techniques. Characterization studies included size, nanoparticle tracking analysis, flow cytometry, size exclusion chromatography, DSC, encapsulation efficiency. This study provides an overview of the preparation and characterization techniques of magnetic nanoliposomes.
磁性纳米脂质体是靶向药物递送的多功能纳米载体。这些脂质体可以通过改善药动学参数来提高生物活性化合物的功效。磁性纳米脂质体的化学成分包括铁磁流体、胆固醇和磷脂分子。磁性纳米脂质体的制备分为两个步骤,即磁性纳米颗粒的合成以及与制备好的纳米脂质体的结合。采用共沉淀法、热分解法、微乳液法和水热法合成磁性纳米脂质体。采用超声、挤压、微流化等技术制备纳米脂质体。表征研究包括粒径、纳米颗粒跟踪分析、流式细胞术、粒径排除色谱、DSC、包封效率。本文综述了磁性纳米脂质体的制备和表征技术。
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引用次数: 0
ROLE OF PI3K/AKT PATHWAY IN PROTECTION OF ISONIAZID/RIFAMPICIN-INDUCED HEPATOTOXICITY: A PHARMACOLOGICAL APPROACH pi3k / akt通路在异烟肼/利福平诱导的肝毒性保护中的作用:药理学方法
Pub Date : 2021-01-01 DOI: 10.21276/bpr.2021.11.1
G. Gupta, Anurag Mishra, Sachchidanand Pathak, S. Singh, Himmat Singh, R. Dahiya
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引用次数: 0
ANTIBACTERIAL ACTIVITY STUDIES ON PAPAYA LEAVES AND ORANGE PEELS AGAINST COMMON BACTERIAL SPECIES 木瓜叶和橘子皮对常见细菌的抑菌活性研究
Pub Date : 2021-01-01 DOI: 10.21276/bpr.2021.11.2
Ramona Alfred Vas, P. Patil, S. Pandey
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引用次数: 0
BIOAVAILABILITY ENHANCEMENT AND LIPID NANOCARRIER BASED DELIVERY OF PEPTIDES AND PROTEINS 生物利用度增强和基于脂质纳米载体的多肽和蛋白质递送
Pub Date : 2020-01-01 DOI: 10.21276/bpr.2020.10.3
S. Dahiya, R. Dahiya
Peptides and proteins are vital biomacromolecules that perform several bodily functions in various physiological and biological processes. Being biocompatible and biodegradable, these macromolecules are considered promising platforms for delivery of drugs and genes. However, peptides and proteins suffer from major limitations including enzymatic degradation, short circulation half-lives, and poor membrane permeability that leads to poor bioavailability, challenging their effective delivery. This article briefly discusses the inherent challenges in peptide and protein delivery along with strategies for bioavailability enhancement and lipid nanocarriers as prospective systems for peptide and protein drug delivery.
多肽和蛋白质是重要的生物大分子,在各种生理和生物过程中发挥多种身体功能。由于具有生物相容性和可生物降解性,这些大分子被认为是递送药物和基因的有前途的平台。然而,多肽和蛋白质受到酶降解、循环半衰期短和膜渗透性差等主要限制,导致生物利用度差,挑战了它们的有效递送。本文简要讨论了肽和蛋白质递送的内在挑战,以及生物利用度增强策略和脂质纳米载体作为肽和蛋白质药物递送的前瞻性系统。
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引用次数: 0
DEVELOPMENT AND VALIDATION OF NEW RP-HPLC METHOD FOR QUANTITATIVE ESTIMATION OF GUAIFENESIN IN TABLET DOSAGE FORM 新的反相高效液相色谱法测定片剂型中愈创甘油醚的含量
Pub Date : 2019-01-01 DOI: 10.21276/bpr.2019.9.4
Punagoti Ra, Getaw Ns, R. Mourya
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引用次数: 2
INCIDENCE AND ANTIBIOTIC SENSITIVITY PATTERNS OF HAEMOLYTIC STRAINS OF STAPHYLOCOCCUS AUREUS ISOLATED FROM THE ENVIRONMENTS OF PAEDIATRIC WARDS OF SELECTED HOSPITALS IN OSOGBO, OSUN STATE, NIGERIA 从尼日利亚奥索博、奥孙州选定医院儿科病房环境中分离出的金黄色葡萄球菌溶血性菌株的发病率和抗生素敏感性模式
Pub Date : 2019-01-01 DOI: 10.21276/bpr.2019.9.3
Alalade Ob, Adeosun Ij, Ajayeoba Ta
{"title":"INCIDENCE AND ANTIBIOTIC SENSITIVITY PATTERNS OF HAEMOLYTIC STRAINS OF STAPHYLOCOCCUS AUREUS ISOLATED FROM THE ENVIRONMENTS OF PAEDIATRIC WARDS OF SELECTED HOSPITALS IN OSOGBO, OSUN STATE, NIGERIA","authors":"Alalade Ob, Adeosun Ij, Ajayeoba Ta","doi":"10.21276/bpr.2019.9.3","DOIUrl":"https://doi.org/10.21276/bpr.2019.9.3","url":null,"abstract":"","PeriodicalId":9368,"journal":{"name":"Bulletin of Pharmaceutical Research Institute","volume":"164 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77482187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ISOLATION OF BETA-ASARONE AND FORSKOLIN AND THEIR IN VIVO ACTIVITY AGAINST STRESS -细辛酮和福斯克林的分离及其体内抗应激活性
Pub Date : 2019-01-01 DOI: 10.21276/bpr.2019.9.2
Tiwari N
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引用次数: 0
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Bulletin of Pharmaceutical Research Institute
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