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Incorporation of Edited MRS into Clinical Practice May Improve Care of Patients with IDH-Mutant Glioma. 在临床实践中采用编辑磁共振成像技术可改善对 IDH 突变胶质瘤患者的治疗。
Pub Date : 2024-10-31 DOI: 10.3174/ajnr.A8413
Lucia Nichelli, Capucine Cadin, Patrizia Lazzari, Bertrand Mathon, Mehdi Touat, Marc Sanson, Franck Bielle, Małgorzata Marjańska, Stéphane Lehéricy, Francesca Branzoli

Background and purpose: Isocitrate dehydrogenase (IDH) mutation and 1p/19q codeletion classify adult-type diffuse gliomas into 3 tumor subtypes with distinct prognoses. We aimed to evaluate the performance of edited MR spectroscopy for glioma subtyping in a clinical setting, via the quantification of D-2-hydroxyglutarate (2HG) and cystathionine. The delay between this noninvasive classification and the integrated histomolecular analysis was also quantified.

Materials and methods: Subjects with presumed low-grade gliomas eligible for surgery (cohort 1) and subjects with IDH-mutant gliomas previously treated and with progressive disease (cohort 2) were prospectively examined with a single-voxel Mescher-Garwood point-resolved spectroscopy sequence at 3T. Spectra were quantified using LCModel. The Cramér-Rao lower bounds threshold was set to 20%. Integrated histomolecular analysis according to the 2021 WHO classification was considered as ground truth.

Results: Thirty-four consecutive subjects were enrolled. Due to poor spectra quality and lack of histologic specimens, data from 26 subjects were analyzed. Twenty-one belonged to cohort 1 (11 women; median age, 42 years); and 5, to cohort 2 (3 women; median age, 48 years). Edited MR spectroscopy showed 100% specificity for detection of IDH-mutation and 91% specificity for the prediction of 1p/19q-codeletion status. Sensitivities for the prediction of IDH and 1p/19q codeletion were 69% and 33%, respectively. The median Cramér-Rao lower bounds values were 16% (13%-28%) for IDH-mutant and 572% (554%-999%) for IDH wild type tumors. The time between MR spectroscopy and surgery was longer for low-grade than for high-grade gliomas (P = .03), yet the time between MR spectroscopy and WHO diagnosis did not differ between grades (P = .07), possibly reflecting molecular analyses-induced delays in high-grade gliomas.

Conclusions: Our results, acquired in a clinic setting, confirmed that edited MR spectroscopy is highly specific for both IDH-mutation and 1p/19q-codeletion predictions and can provide a faster prognosis stratification. In the upcoming IDH-inhibitor treatment era, incorporation of edited MR spectroscopy into clinical workflow is desirable.

背景和目的:异柠檬酸脱氢酶(IDH)突变和1p/19q编码缺失将成人型弥漫性胶质瘤分为三种预后不同的肿瘤亚型。我们的目的是通过对 D-2-羟基戊二酸(2HG)和胱硫醚进行定量,评估编辑磁共振波谱(MRS)在临床环境中对胶质瘤亚型划分的性能。此外,还对这种无创分类与综合组织分子分析之间的延迟进行了量化:对符合手术条件的推测为低级别胶质瘤的受试者(群组 1)和曾接受过治疗且病情进展的 IDH 突变胶质瘤受试者(群组 2)进行了前瞻性检查,在 3 T 下使用单体梅舍尔-加伍德点分辨光谱序列。克拉梅尔-拉奥下限(CRLB)阈值设定为 20%。根据 2021 年世界卫生组织分类进行的综合组织分子分析被视为基本事实:连续 34 名受试者参加了研究。由于光谱质量差和缺乏组织学标本,对 26 名受试者的数据进行了分析。21 人属于第一组(11 名女性;中位年龄:42 岁),5 人属于第二组(3 名女性;中位年龄:48 岁)。编辑的 MRS 对检测 IDH 突变的特异性为 100%,对预测 1p/19q 编码缺失状态的特异性为 91%。预测 IDH 和 1p/19q 编码缺失的灵敏度分别为 62% 和 33%。IDH突变型肿瘤的中位CRLB值为14%(13 - 32),IDH凋亡型肿瘤的中位CRLB值为572%(554 - 999)。低级别胶质瘤的MRS和手术之间的时间长于高级别胶质瘤(p = .03),但MRS和WHO诊断之间的时间在级别之间没有差异(p = .07),这可能反映了分子分析在高级别胶质瘤中引起的延迟:我们在临床环境中获得的结果证实,编辑的MRS对IDH突变和1p/19q编码缺失的预测具有高度特异性,能更快地进行预后分层。在即将到来的IDH抑制剂治疗时代,将编辑的MRS纳入临床工作流程是可取的:缩写:2HG = D-2-羟基戊二酸;Cth = 胱硫醚。CRLB:Cramér-Rao 下限;IDH:异柠檬酸脱氢酶。
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引用次数: 0
Reply. 答复
Pub Date : 2024-10-31 DOI: 10.3174/ajnr.A8538
Tshea Dowers, Paula Alcaide-Leon
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引用次数: 0
Visualization of Intracranial Aneurysms Treated with Woven EndoBridge Devices using Ultrashort TE MR Imaging. 使用超短回波时间磁共振成像(UTE-MRI)观察使用 Woven EndoBridge (WEB) 装置治疗的颅内动脉瘤。
Pub Date : 2024-10-31 DOI: 10.3174/ajnr.A8401
Daniel Toth, Stefan Sommer, Riccardo Ludovichetti, Markus Klarhoefer, Jawid Madjidyar, Patrick Thurner, Marco Piccirelli, Miklos Krepsuka, Tim Finkenstädt, Roman Guggenberger, Sebastian Winklhofer, Zsolt Kulcsar, Tilman Schubert

Background and purpose: Assessing the treatment success of intracranial aneurysms treated with Woven EndoBridge (WEB) devices using MRI is important in follow-up imaging. Depicting both the device configuration as well as reperfusion is challenging due to susceptibility artifacts. We evaluated the usefulness of the contrast-enhanced 3D ultrashort TE (UTE) sequence in this setting.

Materials and methods: In this prospective study, 12 patients (9 women) with 15 treated aneurysms were included. These 12 patients underwent 18 MRI examinations. Follow-up UTE-MRI controls were performed on the same 3T scanner. We compared the visualization of device configuration, artifact-related virtual stenosis of the parent vessel, and the WEB occlusion scale in 3D isotropic UTE-MRI postcontrast with standard TOF-MRA with contrast-enhancement (CE) and without IV contrast as well as DSA. Two interventional neuroradiologists rated the images separately and in consensus.

Results: Visualization of the WEB device position and configuration was rated superior or highly superior using the UTE sequence in 17/18 MRIs compared with TOF-MRA. Artifact-related virtual stenosis of the parent vessel was significantly lower in UTE-MRI compared with TOF and CE-TOF. Reperfusion was visible in 8/18 controls on DSA. TOF was able to grade reperfusion correctly in 16 cases; CE-TOF, in 16 cases; and UTE, in 17 cases.

Conclusions: Contrast-enhanced UTE is a novel MRI sequence that shows benefit compared with the standard sequences in noninvasive and radiation-free follow-up imaging of intracranial aneurysms treated using the WEB device.

背景和目的:使用核磁共振成像评估使用 Woven EndoBridge(WEB)装置治疗颅内动脉瘤的成功率对于后续成像非常重要。由于易感伪影的存在,描绘装置构型和再灌注都具有挑战性。我们评估了对比增强三维-超短回声时间(UTE)序列在这种情况下的实用性:在这项前瞻性研究中,共纳入了 12 名患者(9 名女性),他们患有 15 个经过治疗的动脉瘤。这 12 名患者接受了 18 次磁共振成像检查。在同一台 3-Tesla 扫描仪上进行了后续 UTE-MRI 对照。我们比较了对比后三维各向同性 UTE-MRI 与标准飞行时间(TOF)MR 血管造影术(含(CE)和不含静脉注射造影剂)以及 DSA 对设备配置、与伪影相关的母血管虚拟狭窄和 WEB 闭塞规模的可视化效果。两位介入神经放射学专家分别对图像进行评分,并达成一致意见:结果:与 TOF-MRA 相比,在 17/18 例 MRI 中使用 UTE 序列对 WEB 装置位置和配置的可视化效果被评为较好或非常好。与 TOF 和 CE-TOF 相比,UTE-MRI 与伪影相关的母血管虚拟狭窄率明显较低。在 DSA 中,8/18 例对照组可见再灌注。TOF能对16例再灌注进行正确分级,CE-TOF能对16例再灌注进行正确分级,UTE能对17例再灌注进行正确分级:对比增强 UTE 是一种新型磁共振成像序列,与标准序列相比,它在对使用 WEB 设备治疗的颅内动脉瘤进行无创、无辐射随访成像方面具有优势:缩写:ACoA = 前交通动脉,BA = 基底动脉,CEA = 造影剂增强血管造影,ICA = 颈内动脉,MCA = 大脑中动脉,PCom = 后交通动脉 TOF-CE = 造影剂增强飞行时间血管造影,UTE = 超短回波时间,WEB = 织构内桥。
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引用次数: 0
Light-Chain Deposition Diseases of the CNS: Review of Pathogenesis, Imaging Features, and Radiographic Mimics. 中枢神经系统轻链沉积病:中枢神经系统轻链沉积疾病:发病机制、影像学特征和放射学模拟综述》。
Pub Date : 2024-10-31 DOI: 10.3174/ajnr.A8390
Pranjal Rai, Neetu Soni, Girish Bathla, Karuna Raj, Amit Desai, Vivek Gupta, Amit Agarwal

Light-chain deposition disease (LCDD) is a rare CNS disorder characterized by the extracellular accumulation of monoclonal immunoglobulin light chains in various organs. LCDD typically arises secondary to an underlying plasma cell dyscrasia, such as monoclonal gammopathy of undetermined significance or multiple myeloma. However, rare cases can occur in the absence of a demonstrable plasma cell disorder. The kidneys, liver, lungs, and heart are the most affected organs. Intracerebral LCDD, particularly without an underlying plasma cell neoplasm, represents an exceedingly uncommon entity with limited documented cases in the literature. This review article explores the pathogenesis, histopathologic features, and characteristic neuroimaging findings of intracerebral LCDD. We emphasize the diverse imaging presentations of this disease, which can closely resemble other neurologic pathologies. Recognizing these potential mimics is crucial for avoiding misdiagnosis, especially in the absence of a known underlying plasma cell disorder. This article aims to provide a comprehensive overview from a neuroradiologic perspective, facilitating the recognition and differentiation of this challenging entity.

轻链沉积病(LCDD)是一种罕见的中枢神经系统疾病,其特征是单克隆免疫球蛋白轻链在不同器官的细胞外堆积。LCDD 通常继发于潜在的浆细胞异常,如意义未定的单克隆丙种球蛋白病(MGUS)或多发性骨髓瘤。不过,也有极少数病例可在无明显浆细胞障碍的情况下发生。肾脏、肝脏、肺和心脏是受影响最严重的器官。脑内LCDD,尤其是没有潜在浆细胞肿瘤的脑内LCDD,是一种极为罕见的疾病,文献中记载的病例非常有限。这篇综述文章探讨了脑内 LCDD 的发病机制、组织病理学特征和特征性神经影像学发现。我们强调这种疾病的影像学表现多种多样,可能与其他神经系统病变非常相似。识别这些潜在的模仿者对于避免误诊至关重要,尤其是在没有已知潜在浆细胞疾病的情况下。本文旨在从神经放射学的角度提供一个全面的概述,以便于识别和区分这一具有挑战性的实体:LCDD,轻链沉积症;ALD,淀粉样变性。
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引用次数: 0
Meningioma: Molecular Updates from the 2021 World Health Organization Classification of CNS Tumors and Imaging Correlates. 脑膜瘤:2021 年世界卫生组织中枢神经系统肿瘤分类的分子更新及成像相关性。
Pub Date : 2024-10-31 DOI: 10.3174/ajnr.A8368
Neetu Soni, Manish Ora, Girish Bathla, Denes Szekeres, Amit Desai, Jay J Pillai, Amit Agarwal

Meningiomas, the most common primary intracranial neoplasms, account for more than one-third of primary CNS tumors. While traditionally viewed as benign, meningiomas can be associated with considerable morbidity, and specific meningioma subgroups display more aggressive behavior with higher recurrence rates. The risk stratification for recurrence has been primarily associated with the World Health Organization (WHO) histopathologic grade and extent of resection. However, a growing body of literature has highlighted the value of molecular characteristics in assessing recurrence risk. While maintaining the previous classification system, the 5th edition of the 2021 WHO Classification of Central Nervous System tumors (CNS5) book expands upon the molecular information in meningiomas to help guide management. The WHO CNS5 stratifies meningioma into 3 grades (1-3) based on histopathology criteria and molecular profile. The telomerase reverse transcriptase promoter mutations and cyclin-dependent kinase inhibitor 2A/B (CDKN2A/B) deletions now signify a grade 3 meningioma with increased recurrence risk. Tumor location also correlates with underlying mutations. Cerebral convexity and most spinal meningiomas carry a 22q deletion and/or NF2 mutations, while skull base meningiomas have AKT1, TRAF7, SMO, and/or PIK3CA mutations. MRI is the primary imaging technique for diagnosing and treatment-planning of meningiomas, while DOTATATE PET imaging offers supplementary information beyond anatomic imaging. Herein, we review the evolving molecular landscape of meningiomas, emphasizing imaging/genetic biomarkers and treatment strategies relevant to neuroradiologists.

脑膜瘤是最常见的原发性颅内肿瘤,占原发性中枢神经系统肿瘤的三分之一以上。虽然脑膜瘤传统上被视为良性肿瘤,但其发病率也相当高,而且特定的脑膜瘤亚群表现得更具侵袭性,复发率更高。复发风险分层主要与世界卫生组织(WHO)的组织病理学分级和切除范围有关。然而,越来越多的文献强调了分子特征在评估复发风险中的价值。2021 年第五版世界卫生组织中枢神经系统肿瘤(CNS5)一书在保留以前的分类系统的同时,扩展了脑膜瘤的分子信息,以帮助指导管理。现在,pTERT 突变和 CDKN2A/B 缺失标志着脑膜瘤 3 级,复发风险增加。肿瘤位置也与潜在的突变有关。凸面脑膜瘤和大多数脊髓脑膜瘤带有 22q 缺失和/或 NF2 突变,而颅底脑膜瘤则带有 AKT1、TRAF7、SMO 和/或 PIK3CA 突变。核磁共振成像是脑膜瘤诊断和治疗计划的主要成像方式,而 DOTATATE-PET 成像则提供了解剖成像之外的补充信息。在此,我们回顾了脑膜瘤不断发展的分子状况,强调了与神经放射科医生相关的成像/遗传生物标志物和治疗策略:AKT1=AKT丝氨酸/苏氨酸激酶1;BAP1=BRCA1相关蛋白1;CDK4/6=环素依赖性激酶4和6;KLF4=克鲁珀尔样因子4;NF2=神经纤维瘤病 2 型;PIK3CA=磷脂酰肌醇-4,5-二磷酸 3-激酶催化亚基 alpha;POLR2A=RNA 聚合酶 II 亚基 A;SMO:SMARCB1=SWItch/sucrose non-fermentable related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1; TERT=Telomerase reverse transcriptase; TRAF7=TNF receptor-associated factor 7.
{"title":"Meningioma: Molecular Updates from the 2021 World Health Organization Classification of CNS Tumors and Imaging Correlates.","authors":"Neetu Soni, Manish Ora, Girish Bathla, Denes Szekeres, Amit Desai, Jay J Pillai, Amit Agarwal","doi":"10.3174/ajnr.A8368","DOIUrl":"10.3174/ajnr.A8368","url":null,"abstract":"<p><p>Meningiomas, the most common primary intracranial neoplasms, account for more than one-third of primary CNS tumors. While traditionally viewed as benign, meningiomas can be associated with considerable morbidity, and specific meningioma subgroups display more aggressive behavior with higher recurrence rates. The risk stratification for recurrence has been primarily associated with the World Health Organization (WHO) histopathologic grade and extent of resection. However, a growing body of literature has highlighted the value of molecular characteristics in assessing recurrence risk. While maintaining the previous classification system, the 5th edition of the 2021 WHO Classification of Central Nervous System tumors (CNS5) book expands upon the molecular information in meningiomas to help guide management. The WHO CNS5 stratifies meningioma into 3 grades (1-3) based on histopathology criteria and molecular profile. The telomerase reverse transcriptase promoter mutations and cyclin-dependent kinase inhibitor 2A/B (<i>CDKN2A</i>/<i>B)</i> deletions now signify a grade 3 meningioma with increased recurrence risk. Tumor location also correlates with underlying mutations. Cerebral convexity and most spinal meningiomas carry a 22q deletion and/or NF2 mutations, while skull base meningiomas have <i>AKT1</i>, <i>TRAF7</i>, <i>SMO</i>, and/or <i>PIK3CA</i> mutations. MRI is the primary imaging technique for diagnosing and treatment-planning of meningiomas, while DOTATATE PET imaging offers supplementary information beyond anatomic imaging. Herein, we review the evolving molecular landscape of meningiomas, emphasizing imaging/genetic biomarkers and treatment strategies relevant to neuroradiologists.</p>","PeriodicalId":93863,"journal":{"name":"AJNR. American journal of neuroradiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comprehensive Review of the Utility of Dynamic Contrast-Enhanced MRI for the Diagnosis and Treatment Assessment of Spinal Benign and Malignant Osseous Disease. 动态对比增强磁共振成像在脊柱良性和恶性骨性疾病诊断和治疗评估中的实用性全面回顾。
Pub Date : 2024-10-31 DOI: 10.3174/ajnr.A8398
Atin Saha, Haley Gibbs, Kyung K Peck, Onur Yildirim, Parsa Nilchian, Sasan Karimi, Eric Lis, Vilma Kosović, Andrei I Holodny

Conventional MRI is currently the preferred imaging technique for detection and evaluation of malignant spinal lesions. However, this technique is limited in its ability to assess tumor viability. Unlike conventional MRI, dynamic contrast-enhanced (DCE) MRI provides insight into the physiologic and hemodynamic characteristics of malignant spinal tumors and has been utilized in different types of spinal diseases. DCE has been shown to be especially useful in the cancer setting; specifically, DCE can discriminate between malignant and benign vertebral compression fractures as well as between atypical hemangiomas and metastases. DCE has also been shown to differentiate between different types of metastases. Furthermore, DCE can be useful in the assessment of radiation therapy for spinal metastases, including the prediction of tumor recurrence. This review considers data analysis methods utilized in prior studies of DCE-MRI data acquisition and clinical implications.

传统磁共振成像是目前检测和评估恶性脊柱病变的首选成像技术。然而,这种技术在评估肿瘤存活能力方面存在局限性。与传统磁共振成像不同,动态对比增强(DCE)磁共振成像可深入了解恶性脊柱肿瘤的生理和血流动力学特征,并已用于不同类型的脊柱疾病。DCE 已被证明在癌症环境中特别有用;特别是,DCE 可以区分恶性和良性椎体压缩性骨折,以及非典型血管瘤和转移瘤。DCE 还能区分不同类型的转移瘤。此外,DCE 还可用于评估脊柱转移瘤的放射治疗,包括预测肿瘤复发。这篇综述探讨了以往 DCE-MRI 数据采集研究中使用的数据分析方法和临床意义。
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引用次数: 0
Regarding "Comparative Evaluation of Lower Gadolinium Doses for MR Imaging of Meningiomas: How Low Can We Go?" 关于 "脑膜瘤 MR 成像中较低钆剂量的比较评估:我们能做到多低?
Pub Date : 2024-10-31 DOI: 10.3174/ajnr.A8417
Antonio Navarro-Ballester
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引用次数: 0
Diagnostic performance of fast brain MRI compared to routine clinical MRI in patients with glioma grade 3 and 4 -a pilot study. 快速脑磁共振成像与常规临床磁共振成像在胶质瘤 3 级和 4 级患者中的诊断性能比较 - 一项试点研究。
Pub Date : 2024-10-30 DOI: 10.3174/ajnr.A8558
Francesca De Luca, Annika Suneson, Annika Kits, Emilia Palmér, Stefan Skare, Anna Falk Delgado

Background and purpose: EPIMix is a fast brain MRI technique not previously investigated in patients with glioma grades 3 and 4. This pilot study aimed to investigate the diagnostic performance of EPIMix in the radiological treatment evaluation of adult patients with glioma grades 3 and 4 compared to routine clinical MRI (rcMRI).

Materials and methods: Patients with glioma grades 3 and 4 investigated with rcMRI and EPIMix were retrospectively included in the study. Three readers (R1-3) participated in the radiological assessment applying Response Assessment for Neuro-oncology Criteria (RANO 2.0), of which two (R1-2) independently evaluated EPIMix and later rcMRI by measuring contrast-enhancing and non-contrastenhancing tumor regions at each follow-up. For cases with discrepant evaluations, an unblinded side-by-side (EPIMix and rcMRI) reading was performed together with a third reader (R3). Comparisons between methods (EPIMix vs. rcMRI) were performed using Weighted Cohen's kappa. The sensitivity and specificity to detect tumor progression (PD) on a follow-up scan were calculated for EPIMix compared to rcMRI with receiver operating characteristic (ROC) curves to assess the area under the curve (AUC).

Results: In 35 patients (mean age 53, 31% females), a total of 93 MRIs encompassing 58 follow-up investigations showed PD at blinded reading in 33% of EPIMix (19/58, R1-2), while in 31% (18/58 exams, R1), and 34% (20/58 exams, R2) of rcMRI. An almost perfect agreement for tumor category assessment was found between EPIMix and rcMRI (EPIMixR1 vs. rcMRIR1 ϰ= 0.96; EPIMixR2 vs. rcMRIR2 ϰ= 0.89). The sensitivity for EPIMix to detect PD was 1.00 (0.81-1.00) for R1 and 0.90 (0.68-0.99) for R2, while the specificity was 0.97 (0.86-1.00) for R1-2. The AUC for PD was 0.99 for R1 (EPIMixR1 vs. rcMRIR1) and 0.94 for R2 (EPIMixR2 vs. rcMRIR2), DeLong's test AUCR1 vs. AUCR2 p=0.20 (R1-2).

Conclusions: In this pilot study, EPIMix was used as a fast MRI alternative for treatment evaluation of patients with glioma grades 3 and 4, with high, but slightly lower diagnostic performance than rcMRI.

Abbreviations: CR = complete response; EPIMix = multi-contrast echo-planar imaging-based technique; PD = progressive disease; PR = partial response; RANO = response assessment in neuro-oncology; R1 = reader 1; R2 = reader 2; R3 = reader 3; rcMRI = routine clinical MRI; SD = stable disease.

背景和目的:EPIMix是一种快速脑部磁共振成像技术,以前从未在3级和4级胶质瘤患者中进行过研究。这项试验性研究旨在调查 EPIMix 与常规临床磁共振成像(rcMRI)相比,在对 3 级和 4 级成年胶质瘤患者进行放射治疗评估时的诊断性能:研究回顾性地纳入了使用rcMRI和EPIMix进行检查的3级和4级胶质瘤患者。三名阅读者(R1-3)参与了采用神经肿瘤学反应评估标准(RANO 2.0)进行的放射学评估,其中两名阅读者(R1-2)在每次随访时通过测量对比增强和非对比增强肿瘤区域,独立评估 EPIMix 和后来的 rcMRI。对于评估结果不一致的病例,由第三位阅读者(R3)进行非盲法并排(EPIMix 和 rcMRI)阅读。不同方法(EPIMix 与 rcMRI)之间的比较采用加权科恩卡帕法进行。通过接收器操作特征曲线(ROC)评估曲线下面积(AUC),计算出 EPIMix 与 rcMRI 相比在后续扫描中检测肿瘤进展(PD)的灵敏度和特异性:在35名患者(平均年龄53岁,31%为女性)的58次随访检查共93次磁共振成像中,33%的EPIMix(19次/58次,R1-2)在盲读时显示出PD,而31%的rcMRI(18次/58次,R1)和34%的rcMRI(20次/58次,R2)在盲读时显示出PD。EPIMix和rcMRI对肿瘤类别的评估几乎完全一致(EPIMixR1 vs. rcMRIR1 ϰ=0.96;EPIMixR2 vs. rcMRIR2 ϰ=0.89)。EPIMix 对 R1 检测 PD 的灵敏度为 1.00(0.81-1.00),对 R2 检测 PD 的灵敏度为 0.90(0.68-0.99),而对 R1-2 检测 PD 的特异性为 0.97(0.86-1.00)。R1(EPIMixR1 vs. rcMRIR1)和R2(EPIMixR2 vs. rcMRIR2)的PD AUC分别为0.99和0.94,DeLong检验AUCR1 vs. AUCR2 p=0.20(R1-2):在这项试验研究中,EPIMix可作为胶质瘤3级和4级患者治疗评估的快速磁共振成像替代方法,其诊断性能较高,但略低于rcMRI:缩写:CR = 完全反应;EPIMix = 基于多对比度回声平面成像技术;PD = 进展性疾病;PR = 部分反应;RANO = 神经肿瘤学反应评估;R1 = 阅读器 1;R2 = 阅读器 2;R3 = 阅读器 3;rcMRI = 常规临床 MRI;SD = 稳定性疾病。
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引用次数: 0
Role of Hypoperfusion Intensity Ratio in Vessel Occlusions: A Review on Safety and Clinical Outcomes. 低灌注强度比在血管闭塞中的作用:安全性和临床结果综述。
Pub Date : 2024-10-30 DOI: 10.3174/ajnr.A8557
Sana Rehman, Arsalan Nadeem, Arbab Burhan Uddin Kasi, Ali Husnain, Summaiyya Waseem, Sohail Kumar, Syed Muhammad Owais, Nasreen Banu, Dhairya A Lakhani, Hamza A Salim, Risheng Xu, Vaibhav S Vagal, Yasmin N Aziz, Argye E Hillis, Victor C Urrutia, Rafael H Llinas, Elisabeth B Marsh, Richard Leigh, Hanzhang Lu, Adam A Dmytriw, Adrien Guenego, Gregory W Albers, Jeremy J Heit, Tobias D Faizy, Vivek S Yedavalli

The hypoperfusion intensity ratio (HIR) is a quantitative metric used in vascular occlusion imaging to evaluate the extent of brain tissue at risk due to hypoperfusion. Defined as the ratio of tissue volume with a time-to-maximum (Tmax) of >10 seconds to that of >6 seconds, HIR assists in differentiating between the salvageable penumbra and the irreversibly injured core infarct. This review explores the role of HIR in assessing clinical outcomes and guiding treatment strategies, including mechanical thrombectomy and thrombolytic therapy, for patients with large vessel occlusions (LVOs). Evidence suggests that higher HIR values are associated with worse clinical outcomes, indicating more severe tissue damage and reduced potential for salvage through reperfusion. Additionally, HIR demonstrates predictive accuracy regarding infarct growth, collateral flow, and the risk of reperfusion hemorrhage. It has shown superiority over traditional metrics, such as core infarct volume, in predicting functional outcomes. HIR offers valuable insights for risk stratification and treatment planning in patients with LVOs and distal medium vessel occlusions (DMVOs). Incorporating HIR into clinical practice enhances patient care by improving decision-making processes, promoting timely interventions, and optimizing post-intervention management to minimize complications and improve recovery outcomes.

低灌注强度比(HIR)是血管闭塞成像中的一种定量指标,用于评估因低灌注而面临风险的脑组织的范围。HIR 的定义是最大时间(Tmax)大于 10 秒的组织体积与大于 6 秒的组织体积之比,它有助于区分可挽救的半影和不可逆转的核心梗死。本综述探讨了 HIR 在评估大血管闭塞(LVO)患者的临床预后和指导治疗策略(包括机械性血栓切除术和溶栓疗法)方面的作用。有证据表明,HIR 值越高,临床预后越差,表明组织损伤越严重,通过再灌注挽救的可能性越小。此外,HIR 还能准确预测梗塞生长、侧支血流和再灌注出血的风险。在预测功能预后方面,它比核心梗死体积等传统指标更有优势。HIR 为 LVO 和远端中血管闭塞 (DMVO) 患者的风险分层和治疗计划提供了宝贵的见解。将 HIR 纳入临床实践可改善决策过程、促进及时干预和优化干预后管理,从而最大限度地减少并发症和改善康复效果,从而加强对患者的护理。
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引用次数: 0
Data-Driven Prognostication in Distal Medium Vessel Occlusions Using Explainable Machine Learning. 利用可解释的机器学习对远端中脉闭塞进行数据驱动预诊
Pub Date : 2024-10-28 DOI: 10.3174/ajnr.A8547
Mert Karabacak, Burak Berksu Ozkara, Tobias D Faizy, Trevor Hardigan, Jeremy J Heit, Dhairya A Lakhani, Konstantinos Margetis, J Mocco, Kambiz Nael, Max Wintermark, Vivek S Yedavalli

Background and purpose: Distal medium vessel occlusions (DMVOs) are estimated to cause acute ischemic stroke (AIS) in 25-40% of cases. Prognostic models can inform patient counseling and research by enabling outcome predictions. However, models designed specifically for DMVOs are lacking.

Materials and methods: This retrospective study developed a machine learning model to predict 90-day unfavorable outcome [defined as a modified Rankin Scale (mRS) score of 3-6] in 164 primary DMVO patients. A model developed with the TabPFN algorithm utilized selected clinical, laboratory, imaging, and treatment data with the Least Absolute Shrinkage and Selection Operator feature selection. Performance was evaluated via 5-repeat 5-fold cross-validation. Model discrimination and calibration were evaluated. SHapley Additive Explanations (SHAP) identified influential features. A web application deployed the model for individualized predictions.

Results: The model achieved an area under the receiver operating characteristic curve of 0.815 (95% CI: 0.79-0.841) for predicting unfavorable outcome, demonstrating good discrimination, and a Brier score of 0.19 (95% CI: 0.177-0.202), demonstrating good calibration. SHAP analysis ranked admission National Institutes of Health Stroke Scale (NIHSS) score, premorbid mRS, type of thrombectomy, modified thrombolysis in cerebral infarction score, and history of malignancy as top predictors. The web application enables individualized prognostication.

Conclusions: Our machine learning model demonstrated good discrimination and calibration for predicting 90-day unfavorable outcomes in primary DMVO strokes. This study demonstrates the potential for personalized prognostic counseling and research to support precision medicine in stroke care and recovery.

Abbreviations: DMVO = Distal medium vessel occlusion; AIS = acute ischemic stroke; mRS = modified Rankin Scale; SHAP = SHapley Additive Explanations; NIHSS = National Institutes of Health Stroke Scale; ST = stroke thrombectomy; TRIPOD = Transparent Reporting of Multivariable Prediction Models for Individual Prognosis or Diagnosis; CT = computed tomography; CTP = CT perfusion; MRI = magnetic resonance imaging; CTA = CT angiography; DVT = deep vein thrombosis; PE = pulmonary emboli; TIA = transient ischemic attack; BMI = body mass index; ALP = alkaline phosphatase; ALT = alanine transaminase; AST = aspartate aminotransferase; NCCT-ASPECTS = Alberta Stroke Program Early CT Score; IVT = intravenous thrombolysis; mTICI = modified thrombolysis in cerebral infarction; ER = emergency room; kNN = k-nearest neighbor; LASSO = Least Absolute Shrinkage and Selection Operator; PDPs = partial dependence plots; ROC = receiver operating characteristic; PRC = precision-recall curve; AUROC = area under the ROC curve; AUPRC = area under the PRC; CI = confidence interval.

背景和目的:据估计,25%-40% 的病例由远端中血管闭塞(DMVO)引起急性缺血性卒中(AIS)。预后模型可通过预测结果为患者咨询和研究提供信息。然而,目前还缺乏专门针对 DMVO 设计的模型:这项回顾性研究开发了一种机器学习模型,用于预测 164 例原发性 DMVO 患者的 90 天不良预后(定义为改良 Rankin 量表(mRS)评分 3-6 分)。使用 TabPFN 算法开发的模型利用了选定的临床、实验室、成像和治疗数据,并使用最小绝对收缩和选择操作器进行特征选择。通过 5 次重复 5 倍交叉验证对其性能进行了评估。对模型辨别和校准进行了评估。SHapley Additive Explanations (SHAP) 确定了有影响力的特征。网络应用程序部署了个性化预测模型:结果:该模型预测不利结果的接收者操作特征曲线下面积为 0.815(95% CI:0.79-0.841),显示出良好的辨别能力;Brier 评分为 0.19(95% CI:0.177-0.202),显示出良好的校准能力。SHAP分析将入院时美国国立卫生研究院卒中量表(NIHSS)评分、病前mRS、血栓切除类型、改良脑梗塞溶栓评分和恶性肿瘤病史列为最主要的预测因素。网络应用可实现个性化预后:我们的机器学习模型在预测原发性DMVO脑卒中90天不良预后方面表现出了良好的辨别能力和校准能力。这项研究展示了个性化预后咨询和研究的潜力,以支持中风护理和康复中的精准医疗:缩写:ABC = 定义;XYZ = 定义。DMVO = 远端中血管闭塞;AIS = 急性缺血性卒中;mRS = 改良 Rankin 量表;SHAP = SHapley Additive Explanations;NIHSS = 美国国立卫生研究院卒中量表;ST = 卒中血栓切除术;TRIPOD = Transparent Reporting of Multivariable Prediction Models for Individual Prognosis or Diagnosis;CT = 计算机断层扫描;CTP = CT 灌注;MRI = 磁共振成像;CTA = CT 血管造影;DVT = 深静脉血栓;PE = 肺栓塞;TIA = 短暂性脑缺血发作;BMI = 体重指数;ALP=碱性磷酸酶;ALT=丙氨酸转氨酶;AST=天冬氨酸氨基转移酶;NCCT-ASPECTS=阿尔伯塔省卒中项目早期 CT 评分;IVT=静脉溶栓;mTICI=改良脑梗塞溶栓;ER=急诊室;kNN=k-近邻;LASSO=最小绝对缩减和选择操作器;PDPs=部分依赖图;ROC=接收者操作特征;PRC=精确度-召回曲线;AUROC=ROC曲线下面积;AUPRC=PRC下面积;CI=置信区间。
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AJNR. American journal of neuroradiology
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