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Prolonged Venous Transit on Perfusion Imaging is Associated with Longer Lengths of Stay in Acute Large Vessel Occlusions. 灌注成像中静脉通过时间延长与急性大血管闭塞症患者住院时间延长有关。
Pub Date : 2024-11-26 DOI: 10.3174/ajnr.A8611
Manisha Koneru, Janet Y Mei, Dhairya A Lakhani, Hamza A Salim, Mona Shahriari, Adam A Dmytriw, Adrien Guenego, Jeremy J Heit, Gregory W Albers, Dylan Wolman, Tobias D Faizy, Benjamin Pulli, Vaibhav Vagal, Aakanksha Sriwastwa, Yasmin Aziz, Risheng Xu, Hanzhang Lu, Victor C Urrutia, Elisabeth B Marsh, Richard Leigh, Mona Bahouth, Rafael H Llinas, Kambiz Nael, ArgyeE Hillis, Vivek S Yedavalli

Background and purpose: Prolonged venous transit (PVT+) is a marker of venous outflow; it is defined as the presence or absence of time-to-maximum ≥10 seconds timing in either the superior sagittal sinus or torcula. This novel perfusion imaging-based metric has been associated with higher odds of mortality and lower odds of functional recovery. This study aims to assess the relationship between PVT on admission perfusion imaging and length of hospital stay in large vessel occlusion strokes successfully reperfused with mechanical thrombectomy.

Materials and methods: Acute ischemic stroke patients with large vessel occlusions in the anterior circulation successfully treated with thrombectomy between 01/2017 and 09/2022 were retrospectively reviewed. The primary outcome was length of stay in the hospital due to the acute stroke event. Univariable and forward stepwise multivariable linear regressions were performed for the primary outcome.

Results: Of 109 patients meeting inclusion, median age was 71 (interquartile range [IQR] 62-80) years. Median hospital length of stay was significantly greater in PVT+ patients (9 [IQR 6-18] days) compared to PVT-patients (6 [IQR 4-12] days, p=0.03). In multivariable regression, PVT+ was significantly associated with length of stay, and PVT+ was associated with approximately two additional days of hospital stay compared to PVT-(p=0.03).

Conclusions: In successfully reperfused large vessel occlusion strokes, PVT+ was associated with an additional two days of hospital stay on average compared to PVT-patients, when adjusting for other clinical covariables. This simple, novel imaging metric is robust in correlating with a range of short and long term clinical outcomes.

Abbreviations: VO = venous outflow; Tmax = time-to-maximum; PVT = prolonged venous transit; AIS-LVO = large vessel occlusion ischemic stroke; SSS = superior sagittal sinus; rCBF = relative cerebral blood flow; IQR = interquartile range; VIF = variance inflation factor.

背景和目的:静脉转运延长(PVT+)是静脉外流的标志物;其定义为上矢状窦或蝶窦存在或不存在时间-最大值≥10 秒计时。这种基于灌注成像的新指标与较高的死亡率和较低的功能恢复几率有关。本研究旨在评估经机械血栓切除术成功再灌注的大血管闭塞性脑卒中患者入院灌注成像中的 PVT 与住院时间之间的关系:对2017年1月1日至2022年9月9日期间成功接受血栓切除术治疗的前循环大血管闭塞性急性缺血性卒中患者进行回顾性研究。主要结果是急性卒中事件导致的住院时间。对主要结果进行了单变量和前向逐步多变量线性回归:109名符合纳入条件的患者中,中位年龄为71岁(四分位距[IQR]62-80)。PVT+患者的中位住院时间(9 [IQR 6-18]天)明显长于PVT患者(6 [IQR 4-12]天,P=0.03)。在多变量回归中,PVT+ 与住院时间显著相关,与 PVT- 相比,PVT+ 患者住院时间大约增加两天(P=0.03):结论:在成功再灌注的大血管闭塞性脑卒中患者中,与 PVT 患者相比,调整其他临床变量后,PVT+ 患者的平均住院时间比 PVT 患者多出两天。这一简单、新颖的成像指标在与一系列短期和长期临床结果的相关性方面非常可靠:缩写:VO = 静脉流出量;Tmax = 最大时间;PVT = 静脉转运时间延长;AIS-LVO = 大血管闭塞性缺血性中风;SSS = 上矢状窦; rCBF = 相对脑血流量;IQR = 四分位数间范围;VIF = 方差膨胀因子。
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引用次数: 0
Long-Term Outcome of Rescue Stenting for Acute Intracranial Atherosclerotic Stenosis Related Large Vessel Occlusion in Anterior Circulation. 对急性颅内动脉粥样硬化性狭窄相关的前循环大血管闭塞进行支架置入术的长期效果。
Pub Date : 2024-11-22 DOI: 10.3174/ajnr.A8598
Hyungjong Park, Byung Moon Kim, Jun-Whee Kim, Jin Woo Kim, Jang-Hyun Baek, Dong Joon Kim, Min Jeoung Kim, Sun Yoon, Chang Ki Jang, Sunghan Kim, JoonNyung Heo, Jung-Keun Lee, In Hwan Lim, Ji Hoe Heo, Hyo Suk Nam, Young Dae Kim

Background and purpose: Rescue stent (RS) is an accepted rescue option after failed mechanical thrombectomy (MT) for acute ischemic stroke due to intracranial atherosclerotic stenosis (ICAS)-related large vessel occlusion (LVO). However, the long-term outcomes (≥ 12 months) of RS have not yet been elucidated.

Materials and methods: We retrospectively analyzed the data of 154 patients with RS for ICAS-related LVO, which were identified from prospectively maintained multicenter database of RS after MT failure, to assess good outcome (mRS 0-2), mortality, stroke recurrence, symptomatic intracranial hemorrhage (SICH) and stent patency.

Results: Among 154 patients, successful recanalization was achieved in 132 (85.7%) after RS. Clinical follow-up was available in 148 patients at 3 months, of whom 126 were followed longer than 12 months. Good outcome was observed in 53.4% (79/148) at 3 months and 53.2% (67/126) at the final assessment among survivors (median [interquartile range (IQR)] months, 33 [13-91]). The overall incidence of mortality was 16.2% (24/148) Mortality occurred in 8.8% (13/148) of patients at 3 months and 8.7% (11/126) thereafter, respectively. Stroke recurrence was 0.7% (1/148) within 3 months and 3.2% (4/126) thereafter. The overall incidence of SICH was 9.5% (14/148). SICH occurred in 8.8% (13/148) within the first 3 months, and in 0.8% (1/126) thereafter. The stented vessel was patent in 81.1% (99/122) at the first follow-up (median [IQR] days, 3 [1-125]) and 96.7% (89/92) at the final follow-up (median [IQR] months, 18 [13-68]).

Conclusions: Patients with RS for ICAS-LVO showed a low stroke recurrence rate in the long term. The long-term patency of rescue stent appears to remain durable, particularly when it remains patent during the initial follow-upABBREVIATIONS: ICAS = intracranial atherosclerotic stenosis; LVO = large vessel occlusion; AIS = acute ischemic stroke; MT = mechanical thrombectomy; RS = rescue stenting; CT = computed tomography; MR = magnetic resonance; MMD = moyamoya disease; Intra-arterial = IA; Intravenous = IV; DAPT = dual antiplatelet therapy.

背景和目的:救治支架(RS)是治疗因颅内动脉粥样硬化性狭窄(ICAS)导致的大血管闭塞(LVO)引起的急性缺血性卒中的机械取栓术(MT)失败后的一种公认的救治方案。然而,RS 的长期疗效(≥ 12 个月)尚未阐明:我们回顾性分析了154例因ICAS相关LVO而接受RS治疗的患者的数据,这些患者是从前瞻性维护的MT失败后RS治疗多中心数据库中找到的,目的是评估良好预后(mRS 0-2)、死亡率、卒中复发、症状性颅内出血(SICH)和支架通畅率:在154名患者中,132人(85.7%)在RS术后成功实现了再通路。对148名患者进行了3个月的临床随访,其中126人的随访时间超过12个月。53.4%的患者(79/148)在3个月时预后良好,53.2%的患者(67/126)在最终评估时预后良好(中位数[四分位距(IQR)]月数,33 [13-91])。总死亡率为 16.2%(24/148),其中 8.8%(13/148)的患者在 3 个月后死亡,8.7%(11/126)的患者在 3 个月后死亡。3个月内中风复发率为0.7%(1/148),3个月后复发率为3.2%(4/126)。SICH的总发生率为9.5%(14/148)。8.8%的患者(13/148)在术后3个月内发生SICH,此后为0.8%(1/126)。在首次随访(中位数[IQR]天数为3[1-125])和最终随访(中位数[IQR]月数为18[13-68])中,支架血管通畅率分别为81.1%(99/122)和96.7%(89/92):结论:接受 RS 治疗的 ICAS-LVO 患者长期卒中复发率较低。结论:接受 RS 治疗的 ICAS-LVO 患者中风的长期复发率较低,救治支架的长期通畅性似乎仍然持久,尤其是在初始随访期间保持通畅的情况下:ICAS=颅内动脉粥样硬化性狭窄;LVO=大血管闭塞;AIS=急性缺血性卒中;MT=机械性血栓切除术;RS=抢救性支架植入术;CT=计算机断层扫描;MR=磁共振;MMD=莫亚莫亚病;动脉内=IA;静脉内=IV;DAPT=双重抗血小板疗法。
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引用次数: 0
Neuroimaging Spectrum of Erdheim-Chester Disease: An Image-based Review. 埃尔德海姆-切斯特病的神经影像谱:基于图像的回顾
Pub Date : 2024-11-22 DOI: 10.3174/ajnr.A8599
Pranjal Rai, Haydern J Swartz, Neetu Soni, John C Benson, Amit Agarwal, Steven A Messina, Paul J Farnsworth, Carrie M Carr, Girish Bathla

Erdheim-Chester Disease (ECD) is a rare, multisystem histiocytic disorder characterized by its variable clinical presentations. Central Nervous System (CNS) involvement is observed in approximately half of ECD patients (up to 76% in some series), and often carries a poorer prognosis. While CNS involvement may remain asymptomatic, others may experience a range of neurological symptoms, including cognitive decline, neuropsychiatric disturbances, motor deficits, cranial or peripheral neuropathies, and endocrine abnormalities.Neuroimaging findings in CNS-ECD are diverse, including neurodegeneration manifesting as cerebral or cerebellar volume loss, solitary or multifocal variably enhancing intraparenchymal lesions along the neuroaxis, meningeal infiltration, involvement of the Hypothalamo-pituitary axis, perivascular sheathing or basal ganglia lesions. Other well documented sites of involvement include the craniofacial region, orbits and spine. Awareness of these findings is relevant, not only because of the non-specific nature of these findings, but also given the high proportion of CNS involvement in ECD as well as the higher mortality associated with CNS involvement.This review provides an in-depth overview of the various manifestations of CNS involvement in ECD and their imaging features, along with a brief overview of the differential considerations which include other histiocytic and non-histiocytic processes.ABBREVIATIONS: ECD=Erdheim-Chester Disease; RDD=Rosai-Dorfman Disease; LCH= Langerhans cell histiocytosis.

埃尔德海姆-切斯特病(Erdheim-Chester Disease,ECD)是一种罕见的多系统组织细胞疾病,临床表现多变。大约一半的 ECD 患者(在某些系列病例中高达 76%)会出现中枢神经系统(CNS)受累,而且往往预后较差。虽然中枢神经系统受累可能没有症状,但其他患者可能会出现一系列神经系统症状,包括认知能力下降、神经精神障碍、运动障碍、颅神经或周围神经病以及内分泌异常。中枢神经系统-ECD的神经影像学检查结果多种多样,包括表现为大脑或小脑体积减小的神经变性、沿神经轴的单发或多灶不同程度增强的实质内病变、脑膜浸润、下丘脑-垂体轴受累、血管周围鞘或基底节病变。其他有据可查的受累部位包括颅面部、眼眶和脊柱。本综述深入概述了 ECD 中枢神经系统受累的各种表现及其影像学特征,并简要介绍了包括其他组织细胞和非组织细胞过程在内的鉴别考虑:ECD=Erdheim-Chester Disease;RDD=Rosai-Dorfman Disease;LCH=朗格汉斯细胞组织细胞增生症。
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引用次数: 0
Safety And Efficacy of the Neuroform Atlas Stent for Treatment of Intracranial Aneurysms: A Systematic Review, Meta-Analysis and Meta-Regression. Neuroform Atlas 支架治疗颅内动脉瘤的安全性和有效性:系统综述、元分析和元回归。
Pub Date : 2024-11-22 DOI: 10.3174/ajnr.A8593
Umar Akram, Shahzaib Ahmed, Zain Ali Nadeem, Mona Shahriari, Hamza Ashraf, Haider Ashfaq, Eeshal Fatima, Muhammad A Raza, Aimen Nadeem, Zuha Majid, Arsalan Nadeem, Tayyab Ahmad, Ammara Akram, Sana Rehman, Abeer Sarwar, Janet Mei, Francis Deng, Licia P Luna, Nathan Hyson, Vivek S Yedavalli

Background: Intracranial aneurysms (IAs) are the major cause of subarachnoid hemorrhage. Stent-assisted coiling, especially with the Neuroform Atlas stent (NAS), has proven more effective than coiling alone for treating these aneurysms.

Purpose: To perform a systematic review and meta-analysis to investigate the efficacy and safety of NAS in treating IAs.

Data sources: A comprehensive literature search was conducted on PubMed, Embase, Cochrane CENTRAL library, and clinicaltrials.gov from inception till June 2024.

Study selection: We included studies on ruptured and unruptured IAs treated with the NAS, covering experimental, observational, and case series across all age groups. The aneurysm occlusion rate was assessed using the Raymond-Roy classification (RROC). The modified Rankin Scale (mRS) and adverse events related to stent use were also recorded.

Data analysis: The statistical analysis was conducted on R version 4.3.2 using the packages "meta" and "metasens". We reported our results as proportions with their corresponding confidence intervals (CIs). Meta-regression, leave-one-out and sensitivity analyses were conducted to confirm the robustness of our results.

Data synthesis: A total of 42 studies including 2434 participants with a mean age of 51 to 73 years were included. Among angiographic outcomes, the final RROC 1/RROC 2 was achieved in 95% of the patients, final RROC 1 in 82%, RROC 2 in 12%, and RROC 3 in 5% of the patients. Additionally, 93% of the patients showed mRS grade 0, 5% showed mRS grade 1, 3% showed mRS grade 2, 2% showed mRS grade 3, 0% showed mRS grade 4, 0% showed mRS grade 5, and 1% showed mRS grade 6. All adverse events had a ≤ 5% rate.

Limitations: Due to limited cause-specific data, we were unable to analyse mortality specific to the stent placement and complications. Despite the large number of studies included, comparative studies were still observed to be scarce.

Conclusions: Although the generalizability of our findings is limited, this study demonstrates that NAS is highly effective for treating IAs, with high occlusion rates and a low incidence of adverse events. The stent's performance, supported by comprehensive analysis, highlights its safety and efficacy in managing both ruptured and unruptured aneurysms.

Abbreviations: NAS = Neuroform Atlas stent; IA = Intracranial aneurysm; SAC = stent-assisted coiling.

背景:颅内动脉瘤(IAs)是蛛网膜下腔出血的主要原因。支架辅助卷曲,尤其是使用 Neuroform Atlas 支架(NAS),已被证明比单独卷曲治疗这些动脉瘤更有效。目的:进行系统回顾和荟萃分析,研究 NAS 治疗 IAs 的有效性和安全性:我们在PubMed、Embase、Cochrane CENTRAL图书馆和clinicaltrials.gov上进行了全面的文献检索:我们纳入了使用NAS治疗破裂和未破裂IAs的研究,涵盖所有年龄段的实验性、观察性和病例系列研究。动脉瘤闭塞率采用雷蒙德-罗伊分类法(Raymond-Roy classification,RROC)进行评估。此外,还记录了改良Rankin量表(mRS)和与支架使用相关的不良事件:统计分析在 R 4.3.2 版本中使用 "meta "和 "metasens "软件包进行。我们以比例及其相应的置信区间(CIs)来报告结果。我们还进行了元回归、撇除和敏感性分析,以确认结果的稳健性:共纳入了 42 项研究,包括 2434 名平均年龄为 51 至 73 岁的参与者。在血管造影结果中,95%的患者达到最终 RROC 1/RROC 2,82%的患者达到最终 RROC 1,12%的患者达到 RROC 2,5%的患者达到 RROC 3。此外,93%的患者mRS分级为0级,5%的患者mRS分级为1级,3%的患者mRS分级为2级,2%的患者mRS分级为3级,0%的患者mRS分级为4级,0%的患者mRS分级为5级,1%的患者mRS分级为6级。所有不良事件的发生率均低于5%:由于特定病因数据有限,我们无法分析与支架置入和并发症相关的死亡率。尽管纳入了大量研究,但对比研究仍然很少:尽管我们的研究结果的推广性有限,但本研究表明,NAS 对治疗内膜异位症非常有效,闭塞率高,不良事件发生率低。该支架的性能得到了全面分析的支持,凸显了其在治疗破裂和未破裂动脉瘤方面的安全性和有效性:缩写:NAS = Neuroform Atlas支架;IA = 颅内动脉瘤;SAC = 支架辅助卷曲。
{"title":"Safety And Efficacy of the Neuroform Atlas Stent for Treatment of Intracranial Aneurysms: A Systematic Review, Meta-Analysis and Meta-Regression.","authors":"Umar Akram, Shahzaib Ahmed, Zain Ali Nadeem, Mona Shahriari, Hamza Ashraf, Haider Ashfaq, Eeshal Fatima, Muhammad A Raza, Aimen Nadeem, Zuha Majid, Arsalan Nadeem, Tayyab Ahmad, Ammara Akram, Sana Rehman, Abeer Sarwar, Janet Mei, Francis Deng, Licia P Luna, Nathan Hyson, Vivek S Yedavalli","doi":"10.3174/ajnr.A8593","DOIUrl":"https://doi.org/10.3174/ajnr.A8593","url":null,"abstract":"<p><strong>Background: </strong>Intracranial aneurysms (IAs) are the major cause of subarachnoid hemorrhage. Stent-assisted coiling, especially with the Neuroform Atlas stent (NAS), has proven more effective than coiling alone for treating these aneurysms.</p><p><strong>Purpose: </strong>To perform a systematic review and meta-analysis to investigate the efficacy and safety of NAS in treating IAs.</p><p><strong>Data sources: </strong>A comprehensive literature search was conducted on PubMed, Embase, Cochrane CENTRAL library, and clinicaltrials.gov from inception till June 2024.</p><p><strong>Study selection: </strong>We included studies on ruptured and unruptured IAs treated with the NAS, covering experimental, observational, and case series across all age groups. The aneurysm occlusion rate was assessed using the Raymond-Roy classification (RROC). The modified Rankin Scale (mRS) and adverse events related to stent use were also recorded.</p><p><strong>Data analysis: </strong>The statistical analysis was conducted on R version 4.3.2 using the packages \"meta\" and \"metasens\". We reported our results as proportions with their corresponding confidence intervals (CIs). Meta-regression, leave-one-out and sensitivity analyses were conducted to confirm the robustness of our results.</p><p><strong>Data synthesis: </strong>A total of 42 studies including 2434 participants with a mean age of 51 to 73 years were included. Among angiographic outcomes, the final RROC 1/RROC 2 was achieved in 95% of the patients, final RROC 1 in 82%, RROC 2 in 12%, and RROC 3 in 5% of the patients. Additionally, 93% of the patients showed mRS grade 0, 5% showed mRS grade 1, 3% showed mRS grade 2, 2% showed mRS grade 3, 0% showed mRS grade 4, 0% showed mRS grade 5, and 1% showed mRS grade 6. All adverse events had a ≤ 5% rate.</p><p><strong>Limitations: </strong>Due to limited cause-specific data, we were unable to analyse mortality specific to the stent placement and complications. Despite the large number of studies included, comparative studies were still observed to be scarce.</p><p><strong>Conclusions: </strong>Although the generalizability of our findings is limited, this study demonstrates that NAS is highly effective for treating IAs, with high occlusion rates and a low incidence of adverse events. The stent's performance, supported by comprehensive analysis, highlights its safety and efficacy in managing both ruptured and unruptured aneurysms.</p><p><strong>Abbreviations: </strong>NAS = Neuroform Atlas stent; IA = Intracranial aneurysm; SAC = stent-assisted coiling.</p>","PeriodicalId":93863,"journal":{"name":"AJNR. American journal of neuroradiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142694080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accuracy of an nnUNet neural network for the automatic segmentation of intracranial aneurysms, their parent vessels and major cerebral arteries from magnetic resonance imaging-Time of flight (MRI-TOF). 从磁共振成像飞行时间(MRI-TOF)自动分割颅内动脉瘤、其母血管和主要脑动脉的 nnUNet 神经网络的准确性。
Pub Date : 2024-11-22 DOI: 10.3174/ajnr.A8607
Elisa Colombo, Mathijs de Boer, Lambertus W Bartels, Luca P Regli, Tristan P C van Doormaal

Background and purpose: To develop a new machine-learning algorithm for fully automatic identification of cerebral arteries and intracranial aneurysms (IAs) based on a manually segmented magnetic resonance imaging with time-of-flight sequences (MRITOF) dataset.

Materials and methods: In this retrospective single-center study, 62 MRI-TOF scans of a total of 73 untreated unruptured IAs were manually color-labelled in 21 classes. A nnUNet architecture was trained on MRI-TOF images. The performance of the automatic segmentation was compared with the manual segmentation using Dice Similarity Coefficient (DSC), Centerline Dice (ClDice) and 95th percentile Hausdorff Distance (HD95). Sensitivity was computed for aneurysm detection.

Results: Across all 21 classes, the median DSC was 0.86 [95CI: 0.81, 0.89], the median ClDice 0.91 [0.85, 0.94] and the median HD95 was 2.9 [1.0, 14.9] mm. Sensitivity of the model for aneurysms detection was 0.8. For this class specifically, a median DSC of 0.88 [0.13, 0.92], median ClDice of 0.89 [0.06, 1.0] and median HD95 of 1.8 [0.58, 81] mm was achieved. The volume of the labelled anatomical structure was the most relevant determinant of accuracy in this model. Median time to predict was 130.6 [60.9, 284.1] seconds.

Conclusions: The nnUNet MRI-TOF based algorithm provided a fast and adequate automatic extraction of unruptured intracranial aneurysms, their parent vessels and the most relevant cerebral arteries. Future steps involve the expansion of the training set with the inclusion of more MRI-TOF studies with and without IAs and its incorporation in 3D imaging viewers and treatment prediction.

Abbreviations: IA = Intracranial Aneurysm; MRI-TOF= Magnetic Resonance Imaging - Time of Flight; DSC = Dice-Sørenson Coefficient; ClDice = Centerline Dice; HD95 = 95th Percentile Hausdorff Distance.

背景和目的:基于人工分割的飞行时间序列磁共振成像(MRITOF)数据集,开发一种新的机器学习算法,用于全自动识别脑动脉和颅内动脉瘤(IAs):在这项回顾性单中心研究中,对总共 73 个未经治疗的未破裂动脉瘤的 62 次 MRI-TOF 扫描进行了 21 类手动彩色标记。在 MRI-TOF 图像上训练了 nnUNet 架构。使用骰子相似系数(DSC)、中心线骰子(ClDice)和第 95 百分位数豪斯多夫距离(HD95)比较了自动分割与人工分割的性能。计算了动脉瘤检测的灵敏度:在所有 21 个等级中,DSC 中位数为 0.86 [95CI:0.81,0.89],ClDice 中位数为 0.91 [0.85,0.94],HD95 中位数为 2.9 [1.0,14.9] mm。该模型对动脉瘤检测的灵敏度为 0.8。该类动脉瘤的 DSC 中位数为 0.88 [0.13, 0.92],ClDice 中位数为 0.89 [0.06, 1.0],HD95 中位数为 1.8 [0.58, 81]毫米。在该模型中,标记解剖结构的体积是决定准确性的最重要因素。中位预测时间为 130.6 [60.9, 284.1] 秒:基于 nnUNet MRI-TOF 的算法可快速、充分地自动提取未破裂的颅内动脉瘤、其母血管和最相关的脑动脉。未来的步骤包括扩大训练集,纳入更多有无颅内动脉瘤的 MRI-TOF 研究,并将其纳入三维成像查看器和治疗预测中:缩写:IA=颅内动脉瘤;MRI-TOF=磁共振成像-飞行时间;DSC=狄斯-索伦森系数;ClDice=中心线狄斯;HD95=第95百分位数豪斯多夫距离。
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引用次数: 0
Hyperperfusion and blood-brain barrier disruption beyond the diffusion-restricted infarct one day after successful mechanical thrombectomy. 成功进行机械性血栓切除术一天后,弥散受限的梗死部位出现高灌注和血脑屏障破坏。
Pub Date : 2024-11-22 DOI: 10.3174/ajnr.A8602
Matthias A Mutke, Arne Potreck, Markus A Möhlenbruch, Sabine Heiland, Sibu Mundiyanapurath, Mirko Pham, Martin Bendszus, Angelika Hoffmann

Background and purpose: Patterns of the cerebral microcirculatory response with changes in the blood brain barrier and perfusion in patients with stroke and a large vessel occlusion are still unclear. We combined dynamic contrast enhancement (DCE) permeability and DSC perfusion MRI to detect such patterns beyond the borders of the diffusion-restricted infarct core after successful recanalization.

Materials and methods: Combined DCE permeability and DSC perfusion MRI were performed prospectively in patients within 24h after successful mechanical recanalization of acute middle cerebral artery occlusion. Perfusion alterations were visually assessed on CBF and CBV maps, blood-brain-barrier disruptions (BBBD) on ktrans-maps and quantitatively evaluated with an ipsi-to contralateral ratio. Additionally, logistic regression analysis was performed for favorable early clinical outcome (NIHSS ≤2 at discharge).

Results: N=38 patients were included in the study. Subtle hyperperfusion beyond the DWI-lesion was present in 13/38 patients (34%) on CBF-maps and elevated CBV in 15/38 patients (39%). In these patients, the ratios between ipsi-and contralateral white matter CBF (p=0.01) and CBV (p<0.01) were elevated compared to patients with normal readings. Subtle, but visually and quantitatively elevated ktrans-values outside the DWI-lesion were observed in 7/38 patients (18%). None of these perfusion alterations were related to clinical outcome.

Conclusions: Combined DCE-permeability and DSC-perfusion imaging is feasible in patients 24 hours after successful thrombectomy and reveals subtle hyperperfusion and BBBD occuring frequently beyond the diffusion restricted infarct core.

Abbreviations: DCE = Dynamic Contrast Enhancement, BBBD = blood brain barrier disruption, MT = Mechanical thrombectomy.

背景和目的:脑卒中和大血管闭塞患者的脑微循环反应模式与血脑屏障和灌注的变化仍不清楚。我们将动态对比增强(DCE)通透性和 DSC 灌注 MRI 结合起来,以检测成功再通畅后弥散受限的梗死核心边界以外的这种模式:对急性大脑中动脉闭塞机械再通成功后24小时内的患者进行前瞻性联合DCE通透性和DSC灌注磁共振成像检查。通过CBF和CBV图直观评估灌注改变,通过ktrans图评估血脑屏障破坏(BBBD),并通过同侧与对侧比值进行定量评估。此外,还对良好的早期临床结果(出院时 NIHSS ≤2)进行了逻辑回归分析:研究共纳入 38 名患者。在 CBF 图上,13/38(34%)名患者出现了 DWI 病灶以外的微小高灌注,15/38(39%)名患者出现了 CBV 升高。在这些患者中,同侧和对侧白质 CBF(p=0.01)和 CBV(p结论:在成功进行血栓切除术 24 小时后的患者中,DCE-渗透性和 DSC-灌注成像相结合是可行的,并能揭示在弥散受限的梗死核心以外经常出现的细微高灌注和 BBBD:缩写:DCE = 动态对比增强;BBBD = 血脑屏障破坏;MT = 机械血栓切除术。
{"title":"Hyperperfusion and blood-brain barrier disruption beyond the diffusion-restricted infarct one day after successful mechanical thrombectomy.","authors":"Matthias A Mutke, Arne Potreck, Markus A Möhlenbruch, Sabine Heiland, Sibu Mundiyanapurath, Mirko Pham, Martin Bendszus, Angelika Hoffmann","doi":"10.3174/ajnr.A8602","DOIUrl":"https://doi.org/10.3174/ajnr.A8602","url":null,"abstract":"<p><strong>Background and purpose: </strong>Patterns of the cerebral microcirculatory response with changes in the blood brain barrier and perfusion in patients with stroke and a large vessel occlusion are still unclear. We combined dynamic contrast enhancement (DCE) permeability and DSC perfusion MRI to detect such patterns beyond the borders of the diffusion-restricted infarct core after successful recanalization.</p><p><strong>Materials and methods: </strong>Combined DCE permeability and DSC perfusion MRI were performed prospectively in patients within 24h after successful mechanical recanalization of acute middle cerebral artery occlusion. Perfusion alterations were visually assessed on CBF and CBV maps, blood-brain-barrier disruptions (BBBD) on ktrans-maps and quantitatively evaluated with an ipsi-to contralateral ratio. Additionally, logistic regression analysis was performed for favorable early clinical outcome (NIHSS ≤2 at discharge).</p><p><strong>Results: </strong>N=38 patients were included in the study. Subtle hyperperfusion beyond the DWI-lesion was present in 13/38 patients (34%) on CBF-maps and elevated CBV in 15/38 patients (39%). In these patients, the ratios between ipsi-and contralateral white matter CBF (p=0.01) and CBV (p<0.01) were elevated compared to patients with normal readings. Subtle, but visually and quantitatively elevated ktrans-values outside the DWI-lesion were observed in 7/38 patients (18%). None of these perfusion alterations were related to clinical outcome.</p><p><strong>Conclusions: </strong>Combined DCE-permeability and DSC-perfusion imaging is feasible in patients 24 hours after successful thrombectomy and reveals subtle hyperperfusion and BBBD occuring frequently beyond the diffusion restricted infarct core.</p><p><strong>Abbreviations: </strong>DCE = Dynamic Contrast Enhancement, BBBD = blood brain barrier disruption, MT = Mechanical thrombectomy.</p>","PeriodicalId":93863,"journal":{"name":"AJNR. American journal of neuroradiology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142694068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Normal Facial Nerve Enhancement on Volumetric Interpolated Breath-hold Examination MRI Sequence. 容积插值屏气检查核磁共振成像序列上的正常面神经增强。
Pub Date : 2024-11-22 DOI: 10.3174/ajnr.A8592
Nanjiba Nawaz, Amit B Desai, Alok A Bhatt

Background and purpose: Enhancement of the facial nerve can be seen on magnetic resonance imaging (MRI) due to its rich arteriovenous plexus. Classically, enhancement of the facial nerve beyond the geniculate ganglion has been described as a normal finding, while enhancement of the canalicular and labyrinthine segments is considered abnormal. We hypothesize facial nerve enhancement of the canalicular and labyrinthine segments is a normal finding on the post-contrast T-weighted, fat-saturated VIBE (volumetric interpolated breath-hold examination) sequence on both 1.5T and 3T scanners.

Materials and methods: Fifty patients without facial nerve symptoms undergoing MRI using the internal auditory canal (IAC) protocol were identified at our institution, 25 cases on a 1.5T scanner and 25 cases on a 3T scanner; a total of 100 facial nerves. Presence or absence of enhancement of the facial nerve segments on the postcontrast T1-weighted, fat-saturated VIBE sequence were independently analyzed by two neuroradiologists.

Results: On 1.5T, out of 50 facial nerves evaluated, percentage of nerves with enhancement at each segment was as follows: 80% canalicular, 92% labyrinthine, 100% tympanic, 100% mastoid, and 80% intraparotid. On 3T, out of 50 facial nerves evaluated, percentage of nerves with enhancement at each segment was as follows: 60% canalicular, 84% labyrinthine, 98% tympanic, 100% mastoid, and 93% intraparotid.

Conclusions: Enhancement of the canalicular and labyrinthine segments of the facial nerve is a normal finding on the postcontrast, T1-weighted fat-saturated VIBE sequence. Careful attention to clinical history and asymmetry should be considered before calling abnormality of the facial nerve.

Abbreviations: IAC, Internal auditory canal; VIBE, Volumetric interpolated breath-hold examination.

背景和目的:由于面神经有丰富的动静脉丛,因此在磁共振成像(MRI)上可以看到面神经增强。传统上,膝状神经节以外的面神经增强被描述为正常现象,而管状神经节和迷走神经节段的增强则被认为是异常的。我们假设,在 1.5T 和 3T 扫描仪上进行对比后 T 加权、脂肪饱和 VIBE(容积插值屏气检查)序列时,管状节段和迷宫段的面神经增强是正常的:在我院确定了 50 名无面神经症状的患者,采用内耳道 (IAC) 方案进行磁共振成像,其中 25 例在 1.5T 扫描仪上进行,25 例在 3T 扫描仪上进行;共计 100 条面神经。由两名神经放射学专家独立分析对比后 T1 加权、脂肪饱和 VIBE 序列上面神经节段有无增强:在 1.5T 上评估的 50 条面神经中,各节段出现强化的神经百分比如下80%为管状神经,92%为迷走神经,100%为鼓膜神经,100%为乳突神经,80%为颈内神经。在 3T 上,在评估的 50 条面神经中,各节段增强的神经百分比如下:管状神经 60%,迷宫神经 84%,乳突内神经 80%:管状神经占 60%,迷走神经占 84%,鼓膜神经占 98%,乳突神经占 100%,颈内神经占 93%:结论:在对比后的 T1 加权脂肪饱和 VIBE 序列中,面神经管状段和迷宫段的增强是正常的。在判定面神经异常之前,应仔细考虑临床病史和非对称性:缩写:IAC,内耳道;VIBE,容积插值屏气检查。
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引用次数: 0
Accuracy of Financial Disclosures by Scientific Presenters/Authors at the ASNR 2024 annual meeting. ASNR 2024 年会科学发言人/作者财务披露的准确性。
Pub Date : 2024-11-22 DOI: 10.3174/ajnr.A8600
Ajay Malhotra, Dheeman Futela, Varun Sheoran, Keervani Kandala, Mihir Khunte, Chris Lee, Seyedmehdi Payabvash, Dheeraj Gandhi

Physician-industry financial relationships can drive research and innovation, improving patient care and outcomes, but potentially raise ethical concerns if not disclosed appropriately. This study shows high rates of non-disclosures by authors/presenters at the ASNR 2024 annual meeting, despite strict requirements. 86.4% of presenters/authors with records in OPD failed to disclose any financial relationship, and 89.9% of total industry payment value was not disclosed. Greater awareness should help improve disclosures and transparency, reducing the risk and perception of bias.ABBREVIATIONS: OPD= open payments database; ASNR= American Society of Neuroradiology.

医生与行业的财务关系可以推动研究和创新,改善患者护理和治疗效果,但如果不适当披露,则可能引发道德问题。本研究显示,尽管有严格的要求,但在 ASNR 2024 年年会上,作者/演讲者未披露财务关系的比例很高。86.4%有OPD记录的演讲者/作者未披露任何财务关系,89.9%的行业付款总值未披露。提高意识应有助于改善披露和透明度,降低偏见的风险和感知:OPD=开放支付数据库;ASNR=美国神经放射学会。
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引用次数: 0
The cortical vein opacification score (COVES) is independently associated with DSA ASITN collateral score. 皮质静脉不透明评分(COVES)与 DSA ASITN 侧支评分独立相关。
Pub Date : 2024-11-22 DOI: 10.3174/ajnr.A8601
Dhairya A Lakhani, Aneri B Balar, Subtain Ali, Musharaf Khan, Hamza Salim, Manisha Koneru, Sijin Wen, Richard Wang, Janet Mei, Argye E Hillis, Jeremy J Heit, Greg W Albers, Adam A Dmytriw, Tobias D Faizy, Max Wintermark, Kambiz Nael, Ansaar T Rai, Vivek S Yedavalli

Background : Pretreatment CTA-based Cortical Vein Opacification Score (COVES) has been shown to predict good functional outcomes at 90 days in patients with acute ischemic stroke secondary to large vessel occlusion (AIS-LVO). This is thought to be related to its ability to measure collateral status (CS). However, its association with the reference standard test, the DSA-based American Society of Interventional and Therapeutic Neuroradiology (ASITN) collateral score, has yet to be established. Therefore, this study assesses the relationship between COVES and ASITN CS.Methods : In this prospectively collected, retrospectively reviewed analysis, patients with anterior circulation LVO from September 1, 2017, to October 1, 2023, were included. The COVES grading, which ranges from 0 to 6, was independently assessed by two board-certified neuroradiologists. The ASITN CS was independently assessed by a board-certified neuroradiologist and the performing neurointerventionalist. Any discrepancies were resolved through consensus review. Spearman's rank correlation, univariable logistic regression, multivariable logistic regression, and receiver operating characteristic curve analysis were performed. A p-value of ≤0.05 was considered significant.Results : In total, 311 consecutive patients (median, IQR=68 years [59-78 years]; 55.9% female) met our inclusion criteria. There was significant positive correlation between COVES and ASITN CS (ρ=0.41,p<0.001), and higher COVES was significantly and independently associated with good ASITN CS (unadjusted-OR=1.74,p<0.001) and adjusted-OR=1.73, p<0.001). ROC analysis showed AUC of 0.71, p<0.001).Conclusion : In conclusion, by demonstrating the independent association of COVES with the reference standard test for collateral status assessment, the ASITN CS, we further validate the role of COVES in estimating collateral status.ABBREVIATIONS: AIS: Acute ischemic stroke; ASITN: American Society of Interventional and Therapeutic Neuroradiology; CS: Collateral status; COVES: Cortical Vein Opacification Score; HIR: Hypoperfusion Intensity Ratio; IVT: Intravenous thrombolysis; LVO: Large vessel occlusion; mRS: modified Rankin score; MT: mechanical thrombectomy; OR: odds ratio; aOR: adjusted odds ratio; ua: unadjusted odds ratio; rCBF: relative cerebral blood flow; Tmax: Time-to-Maximum.

背景:治疗前基于 CTA 的皮质静脉通透性评分(COVES)已被证明可预测继发于大血管闭塞(AIS-LVO)的急性缺血性卒中患者 90 天后的良好功能预后。这被认为与其测量侧支状态(CS)的能力有关。然而,它与参考标准测试--基于 DSA 的美国介入和治疗神经放射学会(ASITN)侧支评分--之间的关系尚未确定。因此,本研究评估了 COVES 与 ASITN CS 之间的关系。方法:在这项前瞻性收集、回顾性分析中,纳入了 2017 年 9 月 1 日至 2023 年 10 月 1 日的前循环 LVO 患者。COVES分级从0到6不等,由两名获得医学会认证的神经放射学专家独立评估。ASITN CS 由一名获得神经放射学医师资格证的医师和执行手术的神经介入医师独立评估。任何差异均通过共识审查解决。进行了斯皮尔曼秩相关分析、单变量逻辑回归分析、多变量逻辑回归分析和接收者操作特征曲线分析。结果:共有 311 名连续患者(中位数,IQR=68 岁 [59-78 岁];55.9% 为女性)符合纳入标准。COVES与ASITN CS之间存在明显的正相关(ρ=0.41,p结论:总之,通过证明COVES与侧支状态评估的参考标准测试--ASITN CS之间的独立关联,我们进一步验证了COVES在估计侧支状态中的作用:AIS:急性缺血性卒中;ASITN:美国介入和治疗神经放射学会;CS:侧支状态;COVES:皮质静脉不透明:HIR:低灌注强度比;IVT:静脉溶栓;LVO:大血管闭塞;mRS:改良 Rankin 评分;MT:机械取栓术;OR:几率比;aOR:调整后几率比;ua:未调整几率比;rCBF:相对脑血流;Tmax:Tmax:最大时间。
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引用次数: 0
[18F]-Fluorodeoxyglucose Uptake as a Marker of Residual Anaplastic and Poorly Differentiated Thyroid Carcinoma Following BRAF-Targeted Therapy. [18F]-氟脱氧葡萄糖摄取作为 BRAF 靶向治疗后残留的无性和分化不良甲状腺癌的标志物
Pub Date : 2024-11-21 DOI: 10.3174/ajnr.A8588
Samir A Dagher, Kim O Learned, Richard Dagher, Jennifer Rui Wang, Xiao Zhao, S Mohsen Hosseini, Anastasios Maniakas, Maria E Cabanillas, Naifa L Busaidy, Ramona Dadu, Priyanka Iyer, Mark E Zafereo, Alexander M Khalaf

Background and purpose: Neoadjuvant BRAF-directed therapy and immunotherapy followed by surgery improves survival in patients with BRAFV600E-mutant anaplastic thyroid carcinoma (ATC), more so in those who have complete ATC pathologic response. This study assesses the ability of FDG-PET to non-invasively detect residual high-risk pathologies including ATC and poorly differentiated thyroid carcinoma (PDTC) in the preoperative setting.

Materials and methods: This retrospective, single-center study included consecutive BRAFV600E-mutant ATC patients treated with at least 30 days of neoadjuvant BRAF-directed therapy and who underwent FDG-PET/CT within 30 days prior to surgery. The highest pathologic grade observed for every head and neck lesion resected was recorded. Each lesion on pre-operative PET/CT was retrospectively characterized. The primary endpoint was to contrast the standardized uptake normalized by lean body mass (SULmax) for lesions with residual high-risk (ATC, PDTC) versus low-risk pathologies (papillary thyroid carcinoma, negative). An optimal SULmax threshold was then identified using a ROC analysis, and the ability of this threshold to non-invasively and preoperatively risk-stratify patients by overall survival was then evaluated with a Kaplan-Meier plot.

Results: 30 patients (mean age 66.5±9.0; 17 males) were included in this study, with 94 surgically sampled lesions. Of these lesions, 57 (60.6%) were low-risk (39 negative, 18 papillary thyroid carcinoma) and 37 (39.4%) were high-risk (29 ATC, 8 PDTC). FDG uptake was higher for high-risk compared to low-risk pathologies: median SULmax 5.01 [IQR 2.81 - 10.95] versus 1.29 [IQR 1.06 - 3.1] (P<.001, Mann-Whitney U test). The sensitivity, specificity, and accuracy for detecting high-risk pathologies at the optimal threshold of SULmax ≥ 2.75 were 0.784 [95% CI 0.628-0.886], 0.702 [95% CI 0.573-0.805], and 0.734 [95% CI 0.637-0.813], respectively. Patients with at least 1 high-risk lesion identified with the aforementioned cut-off had a worse prognosis compared to patients without high-risk lesions in the head and neck: median OS for the former group was 259 days and was not attained for the latter (P=.038, log-rank test).

Conclusions: Preoperative FDG-PET non-invasively identifies lesions with residual high-risk pathologies following neoadjuvant BRAF-directed targeted therapy and immunotherapy for BRAF-mutated ATC. FDG-PET avidity may serve as an early prognostic marker which correlates with residual high-risk pathology in BRAF-mutated ATC following neoadjuvant therapy.

Abbreviations: ATC = anaplastic thyroid carcinoma; IQR = interquartile range; OS = overall survival; PDTC = poorly differentiated thyroid carcinoma; PTC = papillary thyroid carcinoma; ROC = receiver operating characteristic; SUL= standardized uptake value normalized by lean body mass.

背景和目的:BRAFV600E突变型甲状腺癌(ATC)患者接受新辅助BRAF导向治疗和免疫治疗后再进行手术可提高生存率,对那些完全ATC病理反应的患者来说更是如此。本研究评估了FDG-PET在术前非侵入性检测残留高危病变(包括ATC和分化不良甲状腺癌(PDTC))的能力:这项回顾性单中心研究纳入了连续接受至少30天BRAF指导的新辅助治疗的BRAFV600E突变ATC患者,这些患者在术前30天内接受了FDG-PET/CT检查。记录切除的每个头颈部病变的最高病理分级。对术前 PET/CT 上的每个病灶进行回顾性特征描述。主要终点是对比残留高风险病变(ATC、PDTC)与低风险病变(甲状腺乳头状癌、阴性)的标准化摄取归一化(SULmax)。然后使用 ROC 分析确定了最佳 SULmax 阈值,并使用 Kaplan-Meier 图评估了该阈值在无创和术前根据总生存期对患者进行风险分级的能力:本研究共纳入 30 名患者(平均年龄为 66.5±9.0;17 名男性),手术取样病灶 94 个。在这些病灶中,57 例(60.6%)为低风险(39 例阴性,18 例甲状腺乳头状癌),37 例(39.4%)为高风险(29 例 ATC,8 例 PDTC)。与低风险病变相比,高风险病变的 FDG 摄取率更高:中位数 SULmax 为 5.01 [IQR 2.81 - 10.95] 对 1.29 [IQR 1.06 - 3.1](PC结论:术前FDG-PET能无创地识别BRAF突变型ATC新辅助BRAF靶向治疗和免疫治疗后残留高危病变的病灶。FDG-PET 阳性可作为早期预后标志物,与新辅助治疗后 BRAF 突变 ATC 的残留高危病理相关:缩略语:ATC=无性甲状腺癌;IQR=四分位数区间;OS=总生存率;PDTC=分化不良甲状腺癌;PTC=乳头状甲状腺癌;ROC=接收者操作特征;SUL=标准化摄取值,按瘦体重归一化。
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引用次数: 0
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AJNR. American journal of neuroradiology
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