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Workplace noise exposure: Effects on cognition and psychological well-being linked to serum glycogen synthase kinase-3 beta (GSK-3ß) levels. 工作场所噪音暴露:与血清糖原合成酶激酶-3 β (GSK-3ß)水平相关的认知和心理健康的影响
IF 0.9 Pub Date : 2025-01-01 Epub Date: 2025-09-24 DOI: 10.1080/19338244.2025.2564689
Mona Abdallah Ramadan, Ghada Hatem, Reham Abdelmaksoud, Marwa Mohammed Fouad

Noise is an inevitable part of life, particularly in the workplace. Our goal was to determine psychological and cognitive morbidities associated with occupational noise exposure and their relation to serum GSK 3β. We recruited 80 male workers in a cross-sectional design ; 40 were the exposed group, and 40 were the control. Arabic version of the depression, anxiety, and stress scale (DASS 21), Montreal Cognitive Examination Basic (MoCA B) test, and serum GSK 3β were done for the studied groups. Noise-exposed workers were subjected to noise levels ranging from 80 to 86 dB. 37.5% of the exposed group showed statistically significant mild cognitive impairment compared to 15% of the controls. A statistically significant negative correlation existed between MoCA scores and noise exposure duration among the exposed. Serum GSK 3β levels were significantly higher among the exposed group compared to the control group . Additionally, workers with more severe psychological distress and cognitive deterioration also had higher levels of GSK 3β. Occupational noise exposure could negatively affect the cognitive and psychological health .

噪音是生活中不可避免的一部分,尤其是在工作场所。我们的目的是确定与职业性噪声暴露相关的心理和认知疾病及其与血清GSK 3β的关系。我们在横断面设计中招募了80名男性员工;暴露组40人,对照组40人。对实验组进行阿拉伯版抑郁、焦虑和压力量表(DASS 21)、蒙特利尔认知检查基础(MoCA B)测试和血清GSK 3β。受噪音影响的工人所受噪音水平介乎80至86分贝。与15%的对照组相比,37.5%的暴露组出现了统计上显著的轻度认知障碍。暴露者的MoCA评分与噪声暴露时间呈显著负相关。暴露组血清GSK 3β水平明显高于对照组。此外,更严重的心理困扰和认知能力下降的工人也有更高的GSK 3β水平。职业性噪声暴露会对认知和心理健康产生负面影响。
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引用次数: 0
Effect of initiation and cessation of night shift work on health: A retrospective longitudinal study. 夜班工作开始和结束对健康的影响:一项回顾性纵向研究。
IF 0.9 Pub Date : 2025-01-01 Epub Date: 2025-11-09 DOI: 10.1080/19338244.2025.2585263
Seunghyeon Shin

This study aimed to evaluate the changes of health outcomes in individuals who started and those who ceased working the night shift. Linear mixed models were used to determine whether the initiation and cessation groups differed from the control group in terms of annual changes in health outcomes. When comparing the control and initiation groups, The Center of Epidemiological Studies Depression Scale showed significant increase compared to the control group, while the metabolic equivalent task scores showed significant decrease compared to the control group. The body mass index (BMI), total cholesterol, low-density lipoprotein cholesterol, and triglyceride levels showed significant increase compared to the control group, while the high-density lipoprotein cholesterol level showed significant decrease compared to the control group. This study identified depressive mood changes and decreased physical activity as the first manifestations of night shift work. An increase in BMI and worsening of lipid profiles were observed in the cessation group, relative to the control group.

本研究旨在评估开始和停止夜班工作的个体的健康结果的变化。使用线性混合模型来确定开始和停止组在健康结果的年度变化方面是否与对照组不同。与对照组和起始组比较,流行病学研究中心抑郁量表较对照组显著升高,代谢等效任务得分较对照组显著降低。与对照组相比,体重指数(BMI)、总胆固醇、低密度脂蛋白胆固醇、甘油三酯水平显著升高,高密度脂蛋白胆固醇水平显著降低。这项研究确定了抑郁情绪变化和体力活动减少是夜班工作的首要表现。与对照组相比,在戒烟组中观察到BMI的增加和脂质谱的恶化。
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引用次数: 0
Biomonitoring cytogenetic and oxidative-stress related damage in gas station attendants: Buccal micronucleus cytome assay and serum 8-OHdG levels. 生物监测加油站服务员的细胞遗传学和氧化应激相关损伤:口腔微核细胞组测定和血清8-OHdG水平。
IF 0.9 Pub Date : 2025-01-01 Epub Date: 2025-06-17 DOI: 10.1080/19338244.2025.2520850
Aylin Elkama, Nazlican İlik, Kerem Şentürk, Bensu Karahalil

This study assessed the genotoxicity and oxidative DNA damage associated with occupational exposure among gas station attendants. We performed buccal micronucleus cytome analysis and measured serum 8-OHdG levels in 32 pumpers and 32 control subjects. Cytotoxicity biomarkers were higher in the exposed group. No significant effect of smoking on cytogenetic parameters was found. In contrast, a higher frequency of genotoxicity and cytotoxicity biomarkers was observed in pumpers with more than 10 years of employment. Serum 8-OHdG levels were higher in pumpers. While the duration of working increased the serum 8-OHdG levels, smoking had no significant effect. Our findings reveal that gas station attendants are continuously exposed to benzene-induced toxicity at the cellular level. Workers may be at risk of developing cancer in the future, so they should be carefully monitored for the long-term effects.

本研究评估了与加油站服务员职业暴露有关的遗传毒性和氧化性DNA损伤。我们对32名抽血者和32名对照组进行了口腔微核细胞组分析,并测量了血清8-OHdG水平。暴露组细胞毒性生物标志物较高。吸烟对细胞遗传学参数无显著影响。相比之下,在工作超过10年的泵工中观察到更高频率的遗传毒性和细胞毒性生物标志物。泵血组血清8-OHdG水平较高。虽然工作时间增加了血清8-OHdG水平,但吸烟没有显著影响。我们的研究结果表明,加油站服务员在细胞水平上持续暴露于苯引起的毒性。工人将来可能有患癌症的风险,所以他们应该仔细监测其长期影响。
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引用次数: 0
Knowledge levels of final year medical students before and after occupational health and occupational diseases training sessions: An interventional study. 医学生职业健康与职业病培训前后知识水平的介入性研究
IF 0.9 Pub Date : 2025-01-01 Epub Date: 2025-09-15 DOI: 10.1080/19338244.2025.2560917
Elif Reyhan Sahin, Aysen Surmen, Mahmut Saadi Yardim

Many occupational diseases can be prevented or at least mitigated, highlighting the importance of including occupational health education in medical curricula. We aimed to evaluate the knowledge levels of sixth-year students before and after occupational health courses, assess the effectiveness of teaching sessions, and identify necessary improvements in the presentations as part of our self-criticism. Pre- and post-training tests covering key aspects of occupational safety and health and occupational diseases, along with questions regarding students' opinions about the courses, were administered using the Kahoot application. Of 207 students, 191 (92.2%) participated in the study over six months within one academic year. An increase was observed in the number of students who answered all questions correctly after lectures. Additionally, 72.2% found the lecture duration sufficient, while 83.3% reported increased awareness. The study pinpointed the topics where mistakes were most frequent and highlighted these more effectively in future presentations.

许多职业病是可以预防或至少减轻的,这突出了将职业健康教育纳入医学课程的重要性。我们的目的是评估六年级学生在职业健康课程前后的知识水平,评估教学课程的有效性,并确定在演讲中需要改进的地方,作为我们自我批评的一部分。培训前和培训后的测试涵盖了职业安全、健康和职业病的关键方面,以及关于学生对课程的意见的问题,都是使用Kahoot应用程序进行的。在207名学生中,有191名(92.2%)在一学年中参加了为期6个月的研究。讲座结束后,正确回答所有问题的学生人数有所增加。此外,72.2%的人认为讲座时间足够,而83.3%的人表示提高了意识。该研究指出了最容易出错的主题,并在未来的演讲中更有效地强调了这些主题。
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引用次数: 0
Heavy metals levels in pre-diagnostic serum of nonsmokers with cancer of the lung, bladder and prostate, and paired individuals. 非吸烟者肺癌、膀胱癌、前列腺癌及配对者诊断前血清重金属水平。
IF 0.9 Pub Date : 2025-01-01 Epub Date: 2025-10-13 DOI: 10.1080/19338244.2025.2573958
Saverio Caini, Claudia Cosma, Maria Cristina Aprea, Calogero Saieva, Manila Raffaelli, Cinzia Trane, Ida Lureti, Nora de Bonfioli Cavalcabo', Benedetta Bendinelli, Luigi Facchini, Melania Assedi, Giovanna Masala

Chronic exposure to heavy metals has been linked to lung, bladder, and prostate cancer risk, yet the evidence for nonsmoking, non-occupationally exposed individuals remains inconclusive. We conducted a preliminary investigation within the EPIC (European Prospective Investigation into Cancer and nutrition) Florence cohort to compare pre-diagnostic serum levels of Cd, Co, Cr, Mn, Pb, and Tl, among subjects who developed lung, bladder, or prostate cancer during follow-up, and among matched non-cancer controls. For each cancer type, we included 50 cases paired with 50 same-age and -sex non-cancer subjects selected among never and long former smokers. Serum heavy metals levels were quantified using inductively coupled plasma mass spectrometry. Median concentrations did not significantly differ between cancer cases and matched controls for any heavy metal. This exploratory, population-based investigation does not support a role of heavy metals in the etiology of lung, bladder, and prostate cancer among nonsmokers.

长期接触重金属与肺癌、膀胱癌和前列腺癌风险有关,但对于不吸烟、非职业接触者的证据仍不确定。我们在EPIC(欧洲癌症和营养前瞻性调查)Florence队列中进行了初步调查,比较在随访期间发生肺癌、膀胱癌或前列腺癌的受试者和匹配的非癌症对照中诊断前血清中Cd、Co、Cr、Mn、Pb和Tl的水平。对于每种癌症类型,我们包括50个病例和50个年龄和性别相同的非癌症受试者,这些受试者从从不吸烟者和长期吸烟者中选择。采用电感耦合等离子体质谱法测定血清重金属水平。任何重金属的中位浓度在癌症病例和匹配对照之间没有显著差异。这项探索性的、基于人群的调查不支持重金属在非吸烟者肺癌、膀胱癌和前列腺癌的病因学中的作用。
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引用次数: 0
Low-dose ionizing radiation and cancer risk, thyroid alteration in health professionals: A retrospective cohort study. 低剂量电离辐射与癌症风险、健康专业人员甲状腺改变:一项回顾性队列研究。
IF 0.9 Pub Date : 2025-01-01 Epub Date: 2025-07-21 DOI: 10.1080/19338244.2025.2533774
Giuseppe La Torre, Andrea Bongiovanni, David Shaholli, Maria Vittoria Manai, Andrea De Giorgi, Danilo Iera, Leonardo Romano, Giuseppe Adamo, Michele Paolucci, Marco Carnì, Sabina Sernia, Simone De Sio

The aim of this study was assessing the impact of Ionizing radiation (IR) exposure on thyroid function and cancer risk over an 11-year follow-up period among healthcare workers. A retrospective cohort of 585 hospital workers in Rome was carried out. Workers were categorized based on IR exposure levels in the period 2010 - 2020. Survival analysis was conducted to assess the development of thyroid abnormalities and tumors. Exposed workers exhibited a higher risk of developing thyroid alterations, notably hypothyroidism and goiter (HR = 1.69, 95% CI 1.17- 2.43), and a reduced likelihood of developing cancer (HR = 0.24, 95% CI 0.09-0.64). Gender and age were significant risk factors for thyroid alterations, with females and older individuals exhibiting higher susceptibility. This study suggests an increased thyroid issues but reduced cancer rates among exposed to low-dose IR compared to unexposed peers, underscoring the need for further research to enhance occupational health.

本研究的目的是评估电离辐射(IR)暴露对医护人员甲状腺功能和癌症风险的影响,随访11年。对罗马585名医院工作人员进行了回顾性队列研究。工作人员根据2010年至2020年期间的红外暴露水平进行分类。通过生存分析来评估甲状腺异常和肿瘤的发展。暴露的工人患甲状腺病变的风险更高,特别是甲状腺功能减退和甲状腺肿(HR = 1.69, 95% CI 1.17- 2.43),患癌症的可能性降低(HR = 0.24, 95% CI 0.09-0.64)。性别和年龄是甲状腺病变的重要危险因素,女性和老年人表现出更高的易感性。这项研究表明,与未暴露的同龄人相比,暴露于低剂量红外辐射的人甲状腺问题增加,但癌症发病率降低,强调需要进一步研究以加强职业健康。
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引用次数: 0
Assessment of inflammatory status in long-term night shift workers using the CRP-albumin ratio and neutrophil-lymphocyte ratio. 利用crp -白蛋白比率和中性粒细胞-淋巴细胞比率评估长期夜班工人的炎症状态。
Pub Date : 2025-01-01 Epub Date: 2025-03-11 DOI: 10.1080/19338244.2025.2473879
Yusuf Samir Hasanlı

Long-term night shift (NS) work is known to affect the body's circadian rhythm, leading to chronic low-level inflammation. We aimed to evaluate this information for the first time through CRP-Albumin Ratio [CAR] and Neutrophil-Lymphocyte Ratio [NLR] levels. Design is descriptive, cross-sectional. After exclusion criteria, a total of 84 males were included in the study, 38 of whom had been working at NS for at least three months and 46 who had been working on the day shift. Both NLR and CAR levels were significantly higher in NS workers compared to day shift workers (2.19 [%95 CI 1.99-2.39]; 1.84 [%95 CI 1.65-2.03] p = 0.012 and 0.44 [%95 CI 0.32-0.56]; 0.24 [%95 CI 0.18-0.29] p = 0.002, respectively). This supports the idea that chronic low inflammation may occur as a result of disruption of the circadian rhythm.

众所周知,长期夜班工作会影响身体的昼夜节律,导致慢性低水平炎症。我们的目的是首次通过crp -白蛋白比(CAR)和中性粒细胞-淋巴细胞比(NLR)水平来评估这一信息。设计是描述性的、横断面的。排除标准后,共有84名男性被纳入研究,其中38人在NS工作至少三个月,46人在白班工作。NS工人的NLR和CAR水平均显著高于白班工人(2.19 [%95 CI 1.99-2.39];1.84 [% 95 CI 1.65 - -2.03) p = 0.012和0.44 (% 95 CI 0.32 - -0.56);0.24 [% 95 CI 0.18 - -0.29), p = 0.002)。这支持了一种观点,即慢性低炎症可能是昼夜节律中断的结果。
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引用次数: 0
Racial/ethnic disparities in the association of environmental exposure to phthalates and bisphenols mixtures with diabetes mellitus: NHANES 2013-2016. 邻苯二甲酸酯和双酚类混合物环境暴露与糖尿病之间的种族/民族差异:NHANES 2013-2016。
IF 0.9 Pub Date : 2025-01-01 Epub Date: 2025-03-18 DOI: 10.1080/19338244.2025.2480113
Jesús Gibran Hernández-Pérez, Abraham Valenzuela-Sánchez, David S López, Luisa Torres-Sánchez

We evaluated the association between urinary concentrations of phthalates/bisphenols mixtures and diabetes mellitus (DM) and poorly controlled DM, stratified by sex, and race/ethnicity in 2718 adults from the 2013 to 2016 National Health and Nutrition Examination Survey. DM was self-reported or defined by glucose tests/hypoglycemic use. Poorly controlled DM was defined by HbA1c ≥ 8%. Principal component analyses allowed to identify three mixtures: (1) DEHP (di(2-ethylhexyl) phthalate metabolites), (2) LMW/BPs (bisphenol A, F, S, and low molecular weight phthalates), and (3) high molecular weight phthalates. Group weighted quantile sum regression showed that the DEHP mixture was associated with lower DM prevalence in women and "other races" participants. Conversely, the LMW/BPs mixture was associated with higher DM odds, mainly among Mexican Americans. Race/ethnicity seems to determine the association between the different exposure mixtures and DM prevalence and poorly controlled DM.

我们评估了2013年至2016年全国健康与营养调查中2718名成年人尿液中邻苯二甲酸酯/双酚混合物浓度与糖尿病(DM)和控制不佳的DM之间的关系,并按性别、种族/民族进行了分层。糖尿病是自我报告或通过葡萄糖试验/降糖使用来定义的。控制不良的糖尿病以HbA1c≥8%定义。主成分分析允许识别三种混合物:(1)DEHP(二(2-乙基己基)邻苯二甲酸酯代谢物),(2)LMW/BPs(双酚A, F, S和低分子量邻苯二甲酸酯),(3)高分子量邻苯二甲酸酯。分组加权分位数和回归显示,DEHP混合物与女性和“其他种族”参与者中较低的糖尿病患病率相关。相反,LMW/ bp混合与较高的糖尿病几率相关,主要发生在墨西哥裔美国人中。种族/民族似乎决定了不同暴露混合物与糖尿病患病率和糖尿病控制不良之间的关系。
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引用次数: 0
Climate induced heat stress and its psychological effects among South Indian workers. 气候引起的热应激及其对南印度工人的心理影响。
IF 0.9 Pub Date : 2025-01-01 Epub Date: 2025-08-17 DOI: 10.1080/19338244.2025.2545778
Gayathri Kg, Vijayalakshmi P, Krishnan S, Rekha S, Vidhya Venugopal

Objective: Rising temperatures and extreme weather pose a significant public health threat. Workers in low- and middle-income countries are particularly vulnerable to heat stress, which can lead to psychological repercussions, including climate anxiety. This study investigated the psychological impacts of heat stress and coping strategies among workers in relation to climate anxiety.

Method: A cross-sectional survey of 800 indoor and outdoor workers was conducted in 2024. Environmental heat stress was measured using a wet bulb globe temperature (WBGT) monitor, defining heat stress as exceeding task-specific threshold limits. Heat strain indicators (HSIs) such as core body temperature (CBT) and urine specific gravity (USG) were assessed alongside perceived heat stress and psychological impacts using a validated HOTHAPS questionnaire.

Results: The WBGT exceeded recommended limits for 62% of workers (30.3 ± 5.0 °C). Among heat-exposed workers, 80% reported heat-related health symptoms, with a significant rise in HSIs, including CBT (AOR = 1.9; 95% CI: 1.4-2.7). Psychological symptoms were prevalent in 94% of exposed workers, with heightened risks of climate anxiety (AOR = 2.8), stress (AOR = 2.7), and mental fatigue (AOR = 3.7). Women and summer months showed greater vulnerability.

Conclusion: Heat stress significantly affects psychological well-being among South Indian workers. Protective workplace policies are crucial to mitigating climate-induced psychological impacts.

目标:气温上升和极端天气对公众健康构成重大威胁。低收入和中等收入国家的工人特别容易受到热应激的影响,这可能导致包括气候焦虑在内的心理影响。本研究探讨了热应激对工人气候焦虑的心理影响及应对策略。方法:于2024年对800名室内和室外工作人员进行横断面调查。使用湿球温度(WBGT)监测器测量环境热应力,将热应力定义为超过特定任务阈值限制。热应变指标(hsi),如核心体温(CBT)和尿液比重(USG),与感知热应激和心理影响一起使用经过验证的HOTHAPS问卷进行评估。结果:62%的工人WBGT超过推荐限值(30.3±5.0°C)。在热暴露工人中,80%报告了与热有关的健康症状,hsi显著上升,包括CBT (AOR = 1.9;95% ci: 1.4-2.7)。94%的暴露工人普遍存在心理症状,气候焦虑(AOR = 2.8)、压力(AOR = 2.7)和精神疲劳(AOR = 3.7)的风险较高。女性和夏季表现出更大的脆弱性。结论:热应激显著影响南印度工人的心理健康。保护性工作场所政策对于减轻气候引起的心理影响至关重要。
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引用次数: 0
Lifetime occupation assignment and hypertension analysis in a survivor cohort of older adults. 老年人幸存者队列的终身职业分配与高血压分析。
IF 0.9 Pub Date : 2025-01-01 Epub Date: 2025-11-22 DOI: 10.1080/19338244.2025.2591429
Kathlyn J Ronaldson, Win Wah, Cammie Tran, Alice J Owen, Robyn L Woods, Enayet K Chowdhury, John J McNeil, Karen Walker-Bone

Standard codes were assigned to each of up to 3 jobs reported by 12,498 healthy Australian participants of the ASPREE Longitudinal Study of Older Persons (ALSOP) aged ≥ 70 years. Ten job categories for men (n=5444; 92.5%) and 13 for women (n=6370; 90.8%) were generated by grouping like jobs. Inter-group distinctiveness was demonstrated by education, socio-economic status, and lifestyle factors for men and women for the occupational groups. Among men, the highest odds of age-adjusted hypertension were in general managers (1.40; 95% CI 1.08, 1.81) and tradespersons (1.29; 1.05, 1.58), with associations attenuated after controlling for lifestyle factors. Among women, the highest odds of hypertension were in nurses (1.40; 95% CI 1.05, 1.87) and clerks/secretaries (1.28; 1.01, 1.62) in multivariate analysis. This analysis indicates that those who are healthy at ≥ 70 years with a healthy lifestyle may suffer minimal detriment in regard to hypertension status from lifetime occupation.

在ASPREE老年人纵向研究(ALSOP)中,年龄≥70岁的12,498名健康的澳大利亚参与者报告了多达3种工作,每个工作都分配了标准代码。男性的10个工作类别(n=5444, 92.5%)和女性的13个工作类别(n=6370, 90.8%)是通过类似的工作分组产生的。在职业群体中,男性和女性的教育、社会经济地位和生活方式因素显示出群体间的独特性。在男性中,总经理(1.40;95% CI 1.08, 1.81)和商人(1.29;1.05,1.58)患年龄调整高血压的几率最高,在控制了生活方式因素后相关性减弱。多因素分析显示,女性中患高血压的几率最高的是护士(1.40;95% CI 1.05, 1.87)和文员/秘书(1.28;1.01,1.62)。这一分析表明,那些年龄≥70岁且生活方式健康的人,其终生职业对高血压的危害可能最小。
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引用次数: 0
期刊
Archives of environmental & occupational health
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