Pub Date : 2025-01-01Epub Date: 2025-06-23DOI: 10.1080/19338244.2025.2522780
Vivien How, Siti Nurfahirah Muhamad, Rozaini Abdullah, Ho Yu Bin, Maisarah Nasution Waras
This study assessed the correlation between pesticide exposure and metabolic health among 48 nursery operators from conventional and organic farms in Peninsular Malaysia. Statistical analyses included independent t-tests and Mann-Whitney U-tests to compare group differences between conventional and organic operators, while multiple linear regression models were used to examine the correlation between pesticide exposure and health risk indicators. The results revealed that conventional nursery operators showed higher levels of metabolic health indicators, coupled with impaired liver and kidney function compared to organic operators. Significantly lower blood cholinesterase levels were observed among conventional operators, indicating a higher risk of neurotoxicity. The study highlights the substantial health hazards that nursery operators face due to pesticide exposure, especially in conventional farming. It supports the implementation of stronger protective measures, frequent health monitoring, and a transition to safer and more sustainable nursery practices.
{"title":"Evaluation of pesticide health risks and its associated metabolic health Status among nursery operators in Peninsular Malaysia.","authors":"Vivien How, Siti Nurfahirah Muhamad, Rozaini Abdullah, Ho Yu Bin, Maisarah Nasution Waras","doi":"10.1080/19338244.2025.2522780","DOIUrl":"10.1080/19338244.2025.2522780","url":null,"abstract":"<p><p>This study assessed the correlation between pesticide exposure and metabolic health among 48 nursery operators from conventional and organic farms in Peninsular Malaysia. Statistical analyses included independent t-tests and Mann-Whitney U-tests to compare group differences between conventional and organic operators, while multiple linear regression models were used to examine the correlation between pesticide exposure and health risk indicators. The results revealed that conventional nursery operators showed higher levels of metabolic health indicators, coupled with impaired liver and kidney function compared to organic operators. Significantly lower blood cholinesterase levels were observed among conventional operators, indicating a higher risk of neurotoxicity. The study highlights the substantial health hazards that nursery operators face due to pesticide exposure, especially in conventional farming. It supports the implementation of stronger protective measures, frequent health monitoring, and a transition to safer and more sustainable nursery practices.</p>","PeriodicalId":93879,"journal":{"name":"Archives of environmental & occupational health","volume":" ","pages":"175-186"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01Epub Date: 2025-08-09DOI: 10.1080/19338244.2025.2545773
Asuman Aslan Kara, Gülden Sarı, Adem Koyuncu, Cebrail Şimşek
The aim of our study is to highlight the inadequacy of focusing solely on occupational exposure in the diagnosis of lung diseases in coal miners. Other factors, especially environmental exposures, should also be considered. A 74-year-old patient with a 20-year history of coal mining and a complaint of coughing was referred with a preliminary diagnosis of coal worker's pneumoconiosis due to abnormal findings on HRCT. Upon detailed questioning, it was learned that the patient had been keeping pet birds for 15 years. Physical examination, laboratory results, and pulmonary function tests were normal. A biopsy was performed due to the detection of an interstitial pattern in the lung imaging, and the diagnosis of fibrotic hypersensitivity pneumonia was made. Although coal worker's pneumoconiosis was initially considered due to the patient's history of long-term coal mining, careful evaluation of all exposures may enable early diagnosis and treatment of accompanying or underlying diseases.
{"title":"Environmental fibrotic hypersensitivity pneumonitis: A case report in a coal mine worker.","authors":"Asuman Aslan Kara, Gülden Sarı, Adem Koyuncu, Cebrail Şimşek","doi":"10.1080/19338244.2025.2545773","DOIUrl":"10.1080/19338244.2025.2545773","url":null,"abstract":"<p><p>The aim of our study is to highlight the inadequacy of focusing solely on occupational exposure in the diagnosis of lung diseases in coal miners. Other factors, especially environmental exposures, should also be considered. A 74-year-old patient with a 20-year history of coal mining and a complaint of coughing was referred with a preliminary diagnosis of coal worker's pneumoconiosis due to abnormal findings on HRCT. Upon detailed questioning, it was learned that the patient had been keeping pet birds for 15 years. Physical examination, laboratory results, and pulmonary function tests were normal. A biopsy was performed due to the detection of an interstitial pattern in the lung imaging, and the diagnosis of fibrotic hypersensitivity pneumonia was made. Although coal worker's pneumoconiosis was initially considered due to the patient's history of long-term coal mining, careful evaluation of all exposures may enable early diagnosis and treatment of accompanying or underlying diseases.</p>","PeriodicalId":93879,"journal":{"name":"Archives of environmental & occupational health","volume":" ","pages":"249-252"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144805464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01Epub Date: 2025-05-14DOI: 10.1080/19338244.2025.2503917
Ogugua I Nedozi, Temitope O Sogbanmu, Muhammed M Abdulrazaq, Ahmed K Oloyo
Industrial printing inks are major sources of occupational exposure to volatile organic compounds (VOCs) with potential adverse effects. The behavioral, neurological, oxidative, hepatic, and kidney function effects of simulated occupational exposure to VOCs emitted from an industrial printing ink were investigated in laboratory mice, Mus musculus for 4 weeks. Average TVOCs value of 0.5 mg/m3 measured at 10 printing presses was the exposure level utilized in this study. There were significant duration-dependent and sex-disaggregated differences in the behavioral responses; acetylcholinesterase (neurological biomarker) and MDA (lipid peroxidation biomarker) activities significantly increased while SOD and CAT (antioxidants) activities significantly decreased in the brain; ALT, AST, and ALP (liver) as well as bilirubin, urea, and creatinine (kidney) were significantly elevated in exposed mice correlating with histopathologies compared to control. The results showed that long term inhalation of VOCs emitted from industrial printing inks may pose multiple sub-lethal effects in occupationally exposed persons, especially females.
{"title":"Simulated occupational exposure to volatile organic compounds from industrial printing ink alter behavioral, neurological, oxidative, hepatic, and kidney indices in mice.","authors":"Ogugua I Nedozi, Temitope O Sogbanmu, Muhammed M Abdulrazaq, Ahmed K Oloyo","doi":"10.1080/19338244.2025.2503917","DOIUrl":"10.1080/19338244.2025.2503917","url":null,"abstract":"<p><p>Industrial printing inks are major sources of occupational exposure to volatile organic compounds (VOCs) with potential adverse effects. The behavioral, neurological, oxidative, hepatic, and kidney function effects of simulated occupational exposure to VOCs emitted from an industrial printing ink were investigated in laboratory mice, Mus musculus for 4 weeks. Average TVOCs value of 0.5 mg/m3 measured at 10 printing presses was the exposure level utilized in this study. There were significant duration-dependent and sex-disaggregated differences in the behavioral responses; acetylcholinesterase (neurological biomarker) and MDA (lipid peroxidation biomarker) activities significantly increased while SOD and CAT (antioxidants) activities significantly decreased in the brain; ALT, AST, and ALP (liver) as well as bilirubin, urea, and creatinine (kidney) were significantly elevated in exposed mice correlating with histopathologies compared to control. The results showed that long term inhalation of VOCs emitted from industrial printing inks may pose multiple sub-lethal effects in occupationally exposed persons, especially females.</p>","PeriodicalId":93879,"journal":{"name":"Archives of environmental & occupational health","volume":" ","pages":"87-100"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01Epub Date: 2025-06-17DOI: 10.1080/19338244.2025.2519184
Matt C Howard, Brittany Siefert
Background: We assess whether the amount of experienced burnout and its relation to suicidal ideation differs between medical professionals and non-medical professionals.
Methods: In December 2023, we performed searches in EBSCO, PubMed, Google Scholar, and ProQuest. We used a random effects samples-size weighted approach for our meta-analysis of 92 sources.
Results: Our meta-regressions did not identify a statistically significant difference between medical professionals and non-medical professionals in their mean levels of the burnout dimensions (all p > .05). Our meta-regressions did not identify a significant difference in the relation of burnout and suicidal ideation between medical professionals and non-medical professionals (β = -0.06, S.E. = .05, 95%C.I. [-0.15, .03], p = .21, k = 53, n = 68,454), and similar results were found for all burnout dimensions (all p > .05).
Discussion: Our results suggest that burnout is no more important for medical professionals than non-medical professionals.
背景:我们评估医疗专业人员和非医疗专业人员经历过的倦怠程度及其与自杀意念的关系是否存在差异。方法:我们于2023年12月在EBSCO、PubMed、谷歌Scholar和ProQuest中进行了检索。我们使用随机效应样本大小加权方法对92个来源进行meta分析。结果:我们的meta回归没有发现医疗专业人员和非医疗专业人员在职业倦怠维度的平均水平上有统计学上的显著差异(均p < 0.05)。我们的meta回归并未发现医务人员和非医务人员在职业倦怠和自杀意念的关系上存在显著差异(β = -0.06, S.E. = 0.05, 95% ci)。[-0.15, .03], p = .21, k = 53, n = 68,454),所有倦怠维度的结果都相似(p均为0.05)。讨论:我们的研究结果表明,职业倦怠对医疗专业人员来说并不比非医疗专业人员更重要。
{"title":"A meta-analysis of burnout and suicidal ideation among medical professionals: Insights on occupational vulnerabilities.","authors":"Matt C Howard, Brittany Siefert","doi":"10.1080/19338244.2025.2519184","DOIUrl":"10.1080/19338244.2025.2519184","url":null,"abstract":"<p><strong>Background: </strong>We assess whether the amount of experienced burnout and its relation to suicidal ideation differs between medical professionals and non-medical professionals.</p><p><strong>Methods: </strong>In December 2023, we performed searches in EBSCO, PubMed, Google Scholar, and ProQuest. We used a random effects samples-size weighted approach for our meta-analysis of 92 sources.</p><p><strong>Results: </strong>Our meta-regressions did not identify a statistically significant difference between medical professionals and non-medical professionals in their mean levels of the burnout dimensions (all <i>p</i> > .05). Our meta-regressions did not identify a significant difference in the relation of burnout and suicidal ideation between medical professionals and non-medical professionals (<i>β</i> = -0.06, <i>S.E.</i> = .05, <i>95%C.I.</i> [-0.15, .03], <i>p</i> = .21, <i>k</i> = 53, <i>n</i> = 68,454), and similar results were found for all burnout dimensions (all <i>p</i> > .05).</p><p><strong>Discussion: </strong>Our results suggest that burnout is no more important for medical professionals than non-medical professionals.</p>","PeriodicalId":93879,"journal":{"name":"Archives of environmental & occupational health","volume":" ","pages":"151-163"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01Epub Date: 2025-10-15DOI: 10.1080/19338244.2025.2574985
Didem Şahin, Gökçe Gültekin, Busemnaz Avşar Aksu, Yeter Saçlı
This study evaluated peripheral hearing and noise sensitivity among motorcycle couriers in Istanbul. Participants comprised 31 couriers (29 males, 2 females; age: 28.51 ± 6.23) and 30 controls (27 males, 3 females; age: 27.03 ± 4.20). Assessment included Weinstein's Noise Sensitivity Scale, tympanometry, pure tone audiometry, and otoacoustic emissions. Couriers demonstrated significantly elevated hearing thresholds in the right ear at 500 Hz (p = 0.017), 1,000 Hz (p < 0.001), 2,000 Hz (p = 0.004), 4,000 Hz (p = 0.001), 6,000 Hz (p = 0.002), and 8,000 Hz (p < 0.001), and in the left ear at 4,000 Hz (p = 0.010) and 8,000 Hz (p = 0.039). Noise sensitivity scores were significantly higher (p = 0.031). Motorcycle couriers represent an occupational group vulnerable to hearing loss and heightened noise sensitivity. Protective measures should encompass environmental noise mitigation, speed limit regulation, and helmet redesign incorporating ear protection to promote hearing conservation and improve overall well-being.
This study aimed to determine the hopelessness and well-being levels of woman academics during the COVID-19 pandemic. This cross-sectional and analytical study was conducted online between February and May 2022 at the end of the fourth wave of the COVID-19 pandemic. The study was conducted with 341 woman academics from state and foundation universities in Türkiye. The mean score from the Beck Hopelessness Scale was 6.02 ± 4.84, and the mean score from the Flourishing Scale (FS) was 43.50 ± 7.24. There was a significant negative correlation between flourishing scores and low, mild, moderate, and high hopelessness scores (p = .038, p < .001, p = .001, p = .034, respectively); as participants' level of hopelessness increases, their FS scores decrease significantly (r: -.689, p < .001). Revealing the effects of changes in the routine and academic activities of woman academics on hopelessness and well-being during the COVID-19 pandemic process has the potential to reduce possible risks that may develop in pandemics, and contribute to reducing the hopelessness levels and increasing well-being of woman academics.
本研究旨在确定女性学者在COVID-19大流行期间的绝望和幸福水平。这项横断面分析研究是在2022年2月至5月第四波COVID-19大流行结束时在线进行的。这项研究是对来自日本国立大学和基础大学的341名女学者进行的。贝克绝望量表的平均得分为6.02±4.84,繁荣量表(FS)的平均得分为43.50±7.24。繁荣得分与低、轻、中、高绝望得分呈显著负相关(p =。038, p p =。001, p =。分别为034);随着参与者绝望程度的增加,他们的FS得分显著下降(r: -)。689页
{"title":"COVID-19 with woman academicians' perspective in Türkiye: Hopelessness and well-being.","authors":"Didem Kıratlı, Meltem Uğurlu, Tülay Yavan, Eda Şahin","doi":"10.1080/19338244.2025.2455103","DOIUrl":"10.1080/19338244.2025.2455103","url":null,"abstract":"<p><p>This study aimed to determine the hopelessness and well-being levels of woman academics during the COVID-19 pandemic. This cross-sectional and analytical study was conducted online between February and May 2022 at the end of the fourth wave of the COVID-19 pandemic. The study was conducted with 341 woman academics from state and foundation universities in Türkiye. The mean score from the Beck Hopelessness Scale was 6.02 ± 4.84, and the mean score from the Flourishing Scale (FS) was 43.50 ± 7.24. There was a significant negative correlation between flourishing scores and low, mild, moderate, and high hopelessness scores (<i>p</i> = .038, <i>p</i> < .001, <i>p</i> = .001, <i>p</i> = .034, respectively); as participants' level of hopelessness increases, their FS scores decrease significantly (<i>r</i>: -.689, <i>p</i> < .001). Revealing the effects of changes in the routine and academic activities of woman academics on hopelessness and well-being during the COVID-19 pandemic process has the potential to reduce possible risks that may develop in pandemics, and contribute to reducing the hopelessness levels and increasing well-being of woman academics.</p>","PeriodicalId":93879,"journal":{"name":"Archives of environmental & occupational health","volume":" ","pages":"7-15"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01Epub Date: 2024-01-24DOI: 10.1080/19338244.2024.2305803
Özge Gedik Toker, Elif Kuru
Exposure to loud noise or chemical agents may cause hearing disorders such as tinnitus and recruitment, known as an increase in the perception of loudness in addition to hearing loss. Our study aims to evaluate the hearing abilities of hairdressers exposed to noise and chemical agents in the working environment. The study included one hundred hairdressers and one hundred participants who do not work as hairdressers or are nonworkers. The participants' demographic characteristics, working conditions, and auditory complaints were questioned, and each participant completed the Speech, Spatial, and Qualities of Hearing Scale (SSQ). A statistically significant difference was found between the two groups in speech perception, spatial perception, hearing quality, and general SSQ scores. Hairdressers' SSQ scores were significantly lower in all sub-dimensions and general scale scores (p < 0.001). The auditory complaints of the hairdressers and the low SSQ scores indicate that exposure to noise and chemical agents affects the hairdressers' hearing system.
{"title":"The effect of occupational exposure to noise and chemical agents on hearing abilities.","authors":"Özge Gedik Toker, Elif Kuru","doi":"10.1080/19338244.2024.2305803","DOIUrl":"10.1080/19338244.2024.2305803","url":null,"abstract":"<p><p>Exposure to loud noise or chemical agents may cause hearing disorders such as tinnitus and recruitment, known as an increase in the perception of loudness in addition to hearing loss. Our study aims to evaluate the hearing abilities of hairdressers exposed to noise and chemical agents in the working environment. The study included one hundred hairdressers and one hundred participants who do not work as hairdressers or are nonworkers. The participants' demographic characteristics, working conditions, and auditory complaints were questioned, and each participant completed the Speech, Spatial, and Qualities of Hearing Scale (SSQ). A statistically significant difference was found between the two groups in speech perception, spatial perception, hearing quality, and general SSQ scores. Hairdressers' SSQ scores were significantly lower in all sub-dimensions and general scale scores (<i>p</i> < 0.001). The auditory complaints of the hairdressers and the low SSQ scores indicate that exposure to noise and chemical agents affects the hairdressers' hearing system.</p>","PeriodicalId":93879,"journal":{"name":"Archives of environmental & occupational health","volume":" ","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139543591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01Epub Date: 2024-12-23DOI: 10.1080/19338244.2024.2442335
Yu Wang, Jingxuan Yang, Xialian Hu, Jingyi Shi, Jiaxin Deng
Lung cancer is the dominant cause of worldwide cancer mortality. The relationship between pesticide exposure and lung cancer risk has shown mixed results epidemiologically. We hypothesized this discrepancy could arise from the varying effects of different pesticides and conducted this meta-analysis by using three pesticide classification schemes to examine the implications of diverse pesticide exposure types on lung cancer risk. We collected 23 studies to assess the risk of lung cancer with pesticide exposure in the Agricultural Health Study cohort (AHS), and our analysis indicated a surplus incidence of lung cancer associated with organochlorine pesticides (OR = 1.35, 95% CI = 1.04-1.74). However, no significant association was found between exposure to a general set of 33 pesticides and lung cancer risk (OR = 1.04, 95% CI = 0.96-1.13). We anticipate these findings will influence future pesticide application, promoting improved occupational health.
肺癌是全球癌症死亡的主要原因。农药接触与肺癌风险之间的关系在流行病学上显示出复杂的结果。我们假设这种差异可能是由不同农药的不同影响引起的,并通过使用三种农药分类方案进行了荟萃分析,以检验不同农药暴露类型对肺癌风险的影响。我们在农业健康研究队列(AHS)中收集了23项研究来评估农药暴露导致肺癌的风险,我们的分析表明,与有机氯农药相关的肺癌发病率过剩(OR = 1.35, 95% CI = 1.04-1.74)。然而,没有发现暴露于33种农药与肺癌风险之间存在显著关联(OR = 1.04, 95% CI = 0.96-1.13)。我们预计这些发现将影响未来的农药应用,促进改善职业健康。
{"title":"Different types of pesticide exposure and lung cancer incidence in the Agricultural Health Study cohort: A systematic review and meta-analysis.","authors":"Yu Wang, Jingxuan Yang, Xialian Hu, Jingyi Shi, Jiaxin Deng","doi":"10.1080/19338244.2024.2442335","DOIUrl":"10.1080/19338244.2024.2442335","url":null,"abstract":"<p><p>Lung cancer is the dominant cause of worldwide cancer mortality. The relationship between pesticide exposure and lung cancer risk has shown mixed results epidemiologically. We hypothesized this discrepancy could arise from the varying effects of different pesticides and conducted this meta-analysis by using three pesticide classification schemes to examine the implications of diverse pesticide exposure types on lung cancer risk. We collected 23 studies to assess the risk of lung cancer with pesticide exposure in the Agricultural Health Study cohort (AHS), and our analysis indicated a surplus incidence of lung cancer associated with organochlorine pesticides (OR = 1.35, 95% CI = 1.04-1.74). However, no significant association was found between exposure to a general set of 33 pesticides and lung cancer risk (OR = 1.04, 95% CI = 0.96-1.13). We anticipate these findings will influence future pesticide application, promoting improved occupational health.</p>","PeriodicalId":93879,"journal":{"name":"Archives of environmental & occupational health","volume":" ","pages":"263-272"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01Epub Date: 2024-03-04DOI: 10.1080/19338244.2024.2320634
Defne Kalaycı, Mehmet Maruf Aydın, Levent Özdemir
Neurofibromatosis (NF) is a neurocutaneous syndrome characterized by the development of central or peripheral nervous system tumors. The most common form, known as NF1 or Von Recklinghausen's disease, presents with distinct clinical features, including cutaneous and ocular manifestations, along with various other organ and systemic symptoms. While the lung findings associated with neurofibromatosis lack specificity, they can include parenchymal cysts and bullae formation, primarily in the upper-apical regions. Additionally, progressive fibrotic changes, such as ground-glass areas, consolidations, and paving stone patterns, may manifest in the basal parts of the lungs. In this case report, a case of NF1 diagnosed in adulthood and accompanying pneumoconiosis was discussed as a coincidence.
神经纤维瘤病(NF)是一种以中枢或周围神经系统肿瘤为特征的神经皮肤综合征。最常见的形式被称为 NF1 或 Von Recklinghausen 病,具有明显的临床特征,包括皮肤和眼部表现,以及各种其他器官和全身症状。虽然与神经纤维瘤病相关的肺部检查结果缺乏特异性,但可包括肺实质囊肿和鼓泡形成,主要发生在上心尖区。此外,肺基底部位可能会出现进行性纤维化改变,如磨玻璃区、合并症和铺路石形态。在本病例报告中,我们讨论了一例成年后被诊断为 NF1 并伴有尘肺病的病例,认为这是一个巧合。
{"title":"Neurofibromatosis type 1 and pneumoconiosis: A case report on a coincidence.","authors":"Defne Kalaycı, Mehmet Maruf Aydın, Levent Özdemir","doi":"10.1080/19338244.2024.2320634","DOIUrl":"10.1080/19338244.2024.2320634","url":null,"abstract":"<p><p>Neurofibromatosis (NF) is a neurocutaneous syndrome characterized by the development of central or peripheral nervous system tumors. The most common form, known as NF1 or Von Recklinghausen's disease, presents with distinct clinical features, including cutaneous and ocular manifestations, along with various other organ and systemic symptoms. While the lung findings associated with neurofibromatosis lack specificity, they can include parenchymal cysts and bullae formation, primarily in the upper-apical regions. Additionally, progressive fibrotic changes, such as ground-glass areas, consolidations, and paving stone patterns, may manifest in the basal parts of the lungs. In this case report, a case of NF1 diagnosed in adulthood and accompanying pneumoconiosis was discussed as a coincidence.</p>","PeriodicalId":93879,"journal":{"name":"Archives of environmental & occupational health","volume":" ","pages":"107-111"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140029777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01Epub Date: 2024-08-22DOI: 10.1080/19338244.2024.2394418
Asghar Ghahri, Mojdeh Saboji, Hosna Hatami, Amir Ranjbar, Ahmad Salimi, Enayatollah Seydi
Petrol vapors as important occupational and environmental pollutants can cause oxidative stress and may play a role in the development of neurodegenerative diseases along with the risk factors involved. This research is designed as a preliminary study to evaluate the protective effects of apigenin (APG) on oxidative stress caused by petrol vapors inhalation in rats. A total of 24 male Wistar rats were randomly divided into four groups inside the inhalation chamber. Body weight changes and oxidative stress markers were investigated. The average body weight of the group exposed to petrol vapors was significantly lower compared to the other groups. The level of reactive oxygen species (ROS), content of oxidized-glutathione (GSSG), and Malondialdehyde were found to be higher in the petrol-inhaled group, while the content of reduced-glutathione (GSH) was lower compared to the other groups. APG administration did result in any significant improvement in these toxicities induced by petrol vapor. APG administration may ameliorate the petrol-induced oxidative stress. In chronic exposures, in addition to personal protection and engineering control, the use of compounds of natural origin may help in reducing the side effects (such as CNS) caused by exposure to petrol vapors.
汽油蒸汽作为重要的职业和环境污染物,可导致氧化应激,并可能在神经退行性疾病的发展过程中发挥作用,同时还可能涉及相关的风险因素。本研究旨在初步评估芹菜素(APG)对大鼠吸入汽油蒸汽引起的氧化应激的保护作用。研究人员将 24 只雄性 Wistar 大鼠随机分为四组,分别置于吸入室中。对体重变化和氧化应激指标进行了调查。与其他组相比,暴露于汽油蒸汽组的平均体重明显较低。研究发现,与其他组相比,汽油吸入组的活性氧(ROS)水平、氧化谷胱甘肽(GSSG)含量和丙二醛含量较高,而还原谷胱甘肽(GSH)含量较低。施用氮化钾可明显改善汽油蒸汽引起的这些毒性。施用 APG 可改善汽油诱发的氧化应激。在长期接触汽油蒸汽的情况下,除了个人防护和工程控制外,使用天然化合物可能有助于减少因接触汽油蒸汽而产生的副作用(如中枢神经系统)。
{"title":"Apigenin ameliorates petrol vapors-induced oxidative stress as occupational and environmental pollutants in rats: An in vivo study.","authors":"Asghar Ghahri, Mojdeh Saboji, Hosna Hatami, Amir Ranjbar, Ahmad Salimi, Enayatollah Seydi","doi":"10.1080/19338244.2024.2394418","DOIUrl":"10.1080/19338244.2024.2394418","url":null,"abstract":"<p><p>Petrol vapors as important occupational and environmental pollutants can cause oxidative stress and may play a role in the development of neurodegenerative diseases along with the risk factors involved. This research is designed as a preliminary study to evaluate the protective effects of apigenin (APG) on oxidative stress caused by petrol vapors inhalation in rats. A total of 24 male Wistar rats were randomly divided into four groups inside the inhalation chamber. Body weight changes and oxidative stress markers were investigated. The average body weight of the group exposed to petrol vapors was significantly lower compared to the other groups. The level of reactive oxygen species (ROS), content of oxidized-glutathione (GSSG), and Malondialdehyde were found to be higher in the petrol-inhaled group, while the content of reduced-glutathione (GSH) was lower compared to the other groups. APG administration did result in any significant improvement in these toxicities induced by petrol vapor. APG administration may ameliorate the petrol-induced oxidative stress. In chronic exposures, in addition to personal protection and engineering control, the use of compounds of natural origin may help in reducing the side effects (such as CNS) caused by exposure to petrol vapors.</p>","PeriodicalId":93879,"journal":{"name":"Archives of environmental & occupational health","volume":" ","pages":"143-151"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142019867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}