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A geospatial assessment of industrial releases and pediatric neuroblastic tumours at diagnosis: A retrospective case series. 对工业排放物和小儿神经母细胞瘤诊断的地理空间评估:回顾性病例系列
Pub Date : 2023-01-01 Epub Date: 2024-02-07 DOI: 10.1080/19338244.2023.2291734
Domenica Tambasco, Meredith Franklin, Shelley A Harris, Pauline Tibout, Andrea S Doria

Environmental risk factors associated with malignancy of pediatric neuroblastic tumours are not well-known and few studies have examined the relationship between industrial emissions and neuroblastic tumour diagnosis. A retrospective case series of 310 patients was evaluated at a tertiary hospital in Toronto, Canada between January 2008, and December 2018. Data from the National Pollutant Release Inventory (NPRI) were used to estimate exposure for a dozen chemicals with known or suspected carcinogenicity or embryotoxicity. Comparative analysis and predictive logistic regression models for malignant versus benign neuroblastic tumours included variables for residential proximity, number, and type of industries, mean total emissions within 2 km, and inverse distance weighted (IDW) quantity of chemical-specific industrial emissions estimated within 10 and 50 km of cases. No significant difference was seen between malignant and benign cases with respect to the mean nearest residential distance to industry, the number or type of industry, or the mean total quantity of industrial emissions within a 2 km radius of residential location of cases. However, there were statistically significant differences in the interpolated IDW emissions of dioxins and furans released between 1993 and 2019 within 10 km. Concentrations were significantly higher in malignant neuroblastic tumours at 1.65 grams (g) toxic equivalent (TEQ) (SD 2.01 g TEQ) compared to benign neuroblastic tumours at 1.13 g TEQ (SD 0.84 g TEQ) (p = 0.05). Within 50 km 3 years prior to diagnosis, malignant cases were exposed to higher levels of aluminum, benzene, and nitrogen dioxide (p = 0.02, p = 0.04, and p = 0.02 respectively). Regression analysis of the IDW emissions within a 50 km radius revealed higher odds of exposure to benzene for malignant neuroblastic tumours (OR = 1.03, CI: 1.01-1.05, p = 0.01). These preliminary findings suggest a potential role of industrial emissions in the development of malignant pediatric neuroblastic tumours and underscore the need for further research to investigate these associations.

与小儿神经母细胞瘤恶性相关的环境风险因素并不为人所知,很少有研究对工业排放与神经母细胞瘤诊断之间的关系进行研究。2008年1月至2018年12月期间,加拿大多伦多一家三级医院对310名患者进行了回顾性病例系列评估。研究人员利用国家污染物排放清单(NPRI)中的数据估算了十几种已知或疑似具有致癌性或胚胎毒性的化学品的暴露量。恶性神经母细胞瘤与良性神经母细胞瘤的比较分析和预测性逻辑回归模型包括住宅邻近程度、工业数量和类型、2 千米范围内的平均总排放量以及病例周围 10 千米和 50 千米范围内特定化学物质工业排放量的反距离加权 (IDW) 量等变量。恶性病例与良性病例在居住地与工业的最近平均距离、工业数量或类型、病例居住地半径 2 千米范围内的工业排放平均总量方面没有明显差异。然而,1993年至2019年期间,10千米范围内二恶英和呋喃的内插IDW排放量在统计学上存在显著差异。恶性神经母细胞瘤的浓度为 1.65 克毒性当量(SD 2.01 克毒性当量),明显高于良性神经母细胞瘤的 1.13 克毒性当量(SD 0.84 克毒性当量)(p = 0.05)。在确诊前 3 年的 50 公里范围内,恶性病例暴露于较高水平的铝、苯和二氧化氮(分别为 p = 0.02、p = 0.04 和 p = 0.02)。对半径 50 千米范围内的 IDW 排放进行回归分析后发现,暴露于苯的恶性神经细胞肿瘤的几率更高(OR = 1.03,CI:1.01-1.05,p = 0.01)。这些初步研究结果表明,工业排放物在小儿恶性神经母细胞瘤的发病过程中可能扮演了重要角色,并强调有必要进一步研究这些关联。
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引用次数: 0
Cardiovascular disease risk factors in career firefighters: A 6-year follow-up study. 职业消防员心血管疾病危险因素:一项6年随访研究。
Pub Date : 2023-01-01 Epub Date: 2023-12-07 DOI: 10.1080/19338244.2023.2275155
Thomas Sire, Kamille Roy, Philémon Marcel-Millet, Sébastien Poirier, Philippe Gendron

This study sought to investigate the evolution of cardiovascular disease (CVD) risk factors in career firefighters. A questionnaire was sent to a cohort of 233 Québec career firefighters in 2015 and 2021 to collect demographic and occupational information and the presence of CVD risk factors. Ninety-six (96) firefighters (1 female) responded to the questionnaire in 2015 and 2021. Body weight (2015: 88.3 ± 10.9, 2021: 89.6 ± 10.7 kg, p = 0.01), body mass index (2015: 27.6 ± 3.2, 2021: 28.0 ± 3.0 kg/m2, p = 0.01), number of CVD risk factors (2015: 1.1 ± 1.0, 2021: 1.3 ± 0.9 CVD risk factors, p = 0.05), and proportion of firefighters with at least 1 CVD risk factor (2015: 71, 2021: 82%, p = 0.02) increased. Overall, our results highlight an aggravation of several CVD risk factors in Québec career firefighters over the years.

本研究旨在调查职业消防员心血管疾病(CVD)危险因素的演变。2015年和2021年,向233名魁北克职业消防员发送了一份问卷,以收集人口统计和职业信息以及心血管疾病风险因素的存在。九十六(96)名消防员(1名女性)在2015年和2021年对问卷进行了回复。体重(2015年:88.3 ± 2021年10月10日:89.6 ± 10.7 kg,p = 0.01),体重指数(2015:27.6 ± 2021年3月2日:28.0 ± 3 kg/m2,p = 0.01),心血管疾病危险因素数量(2015年:1.1 ± 2021年1月1日:1.3 ± 0.9 CVD危险因素,p = 0.05),以及至少有1个CVD危险因素的消防员比例(2015:712001:82%,p = 0.02)增加。总的来说,我们的研究结果突出了魁北克职业消防员多年来心血管疾病风险因素的恶化。
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引用次数: 0
Chemical contaminant exposures assessed using silicone wristbands among fuel station attendants, taxi drivers and commercial motorcycle riders in Kampala, Uganda. 在乌干达坎帕拉,使用硅胶腕带评估加油站服务员、出租车司机和商用摩托车骑手的化学污染物暴露情况。
Pub Date : 2023-01-01 Epub Date: 2023-12-07 DOI: 10.1080/19338244.2023.2275144
Edwinah Atusingwize, Diana Rohlman, Peter Hoffman, Solomon Tsebeni Wafula, David Musoke, Esther Buregyeya, Richard K Mugambe, Rawlance Ndejjo, John C Ssempebwa, Kim A Anderson

There are concerns over traffic-related air pollution in Uganda's capital, Kampala. Individuals in the transportation sector are hypothesized to be at greater risk for exposure to volatile organic compounds, given their proximity to vehicle exhaust. Silicone wristbands are a wearable technology that passively sample individuals' chemical exposures. We conducted a pilot cross sectional study to measure personal exposures to volatile organic compounds among 14 transportation workers who wore a wristband for five days. We analyzed for 75 volatile organic compounds; 33 chemicals (35%) were detected and quantified in at least 50% of the samples and 15 (16%) chemicals were detected and quantified across all the samples. Specific chemicals were associated with participants' occupation. The findings can guide future large studies to inform policy and practice to reduce exposure to chemicals in the environment in Kampala.

在乌干达首都坎帕拉,人们对与交通有关的空气污染表示担忧。假设运输部门的个人接触挥发性有机化合物的风险更大,因为他们靠近汽车尾气。硅胶腕带是一种可穿戴技术,可以被动地对个人的化学暴露进行采样。我们进行了一项试点横断面研究,以测量14名佩戴腕带五天的运输工人个人暴露于挥发性有机化合物的情况。我们分析了75种挥发性有机化合物;在至少50%的样品中检测并定量了33种化学物质(35%),在所有样品中检测和定量了15种化学物质。特定化学品与参与者的职业有关。这些发现可以指导未来的大型研究,为减少坎帕拉环境中化学品暴露的政策和实践提供信息。
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引用次数: 0
Noise levels and annoyance among staff in a tertiary care hospital in North India: A cross-sectional study. 印度北部一家三级医院工作人员的噪音水平和烦恼:一项横断面研究。
Pub Date : 2023-01-01 Epub Date: 2024-02-07 DOI: 10.1080/19338244.2023.2286388
Aritrik Das, Jugal Kishore

Hospital noise has remained a low priority problem in India. An area of not less than 100 meters around a hospital is considered a silence zone, with guidelines restricting noise levels at 50dBA during daytime and 40dBA during the night. World Health Organization (WHO) guidelines also stipulate an average of 30dBA and a maximum of 40dbA. Annoyance is a known effect of noise exposure. However, very few studies have attempted to explore the hospital soundscape and the annoyance among staff related to it. Noise data was collected from 30 sites, using a Digital Integrating Sound Level Meter, LutronSL-4035SD (ISO-9001,CE,IEC1010) meeting IEC61672 standards. Stratified random sampling of staff was done on basis of noise exposure. A pre-designed, semi-structured questionnaire collected information on sociodemographic and work profile. Annoyance was defined as a stress reaction to environmental noise and was measured using standardized general purpose noise reaction questionnaire (ISO-TS/15666). Data was analyzed in SPSS. The mean LAeq 24 h across all the sites was 69.5dBA (SD ±5.8dBA) for the weekdays and 66.2dBA (SD ±4.6dBA) for the weekends. Noise levels were higher during the day than during the night, and higher during the weekdays as compared to the weekends. 332(73.8%) study participants were found to be annoyed due to hospital noise. Annoyance among study participants was significantly associated with LAeq 24 h > 80 dBA during the weekdays [aOR = 5.08 (1.17-22.06)] and LAeq 24 h of 65-80 dBA during the weekends [aOR = 2.71 (1.46-5.01)]. Noise levels in the hospital far exceeded WHO and Central Pollution Control Board (CPCB) guidelines recommended for indoor hospital noise, as well as the national guidelines for sensitive zones. Almost three-fourth of the study participants were annoyed due to hospital noise. Significant association was found between annoyance among staff and higher noise levels of their workplace. Similar studies need to be conducted in hospitals across India to generate evidence on the current situtation and identify solutions.

医院噪音在印度仍然是一个不太重要的问题。医院周围不少于100米的区域被认为是安静区,指导方针将噪音水平限制在白天50dBA,晚上40dBA。世界卫生组织(WHO)的指导方针也规定了平均30dBA和最高40dbA。烦恼是暴露在噪音中的一种已知影响。然而,很少有研究试图探讨医院的音景和与之相关的员工的烦恼。使用符合IEC61672标准的数字集成声级计lutreon - 4035sd (ISO-9001,CE,IEC1010)从30个站点收集噪声数据。根据噪声暴露情况对工作人员进行分层随机抽样。预先设计的半结构化问卷收集了社会人口统计和工作概况的信息。烦恼被定义为对环境噪声的应激反应,采用标准化通用噪声反应问卷(ISO-TS/15666)进行测量。数据用SPSS进行分析。24 h平均LAeq在工作日为69.5dBA (SD±5.8dBA),在周末为66.2dBA (SD±4.6dBA)。白天的噪音水平比晚上高,工作日的噪音水平比周末高。332名(73.8%)研究参与者被发现因医院噪音而烦恼。研究参与者的烦恼与工作日LAeq 24小时> 80 dBA [aOR = 5.08(1.17-22.06)]和周末LAeq 24小时> 65-80 dBA [aOR = 2.71(1.46-5.01)]显著相关。医院的噪音水平远远超过世卫组织和中央污染控制委员会建议的医院室内噪音准则,以及敏感地区的国家准则。近四分之三的研究参与者因医院的噪音而感到烦恼。研究发现,员工的烦恼与工作场所的高噪音水平之间存在显著关联。需要在印度各地的医院进行类似的研究,以得出关于目前情况的证据并确定解决办法。
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引用次数: 0
The prevalence of smoking among soldiers of the gendarmerie in a provincial center and affecting factors: A cross-sectional study from Turkey. 省级中心宪兵队士兵吸烟率及其影响因素:一项来自土耳其的横断面研究。
Pub Date : 2023-01-01 Epub Date: 2023-11-02 DOI: 10.1080/19338244.2023.2262923
Murat Melih Erdoğan, Semra Kocataş

Determining the smoking rates and nicotine dependency levels of soldiers can be a guide in smoking cessation interventions and developing a policy for smoking prevention for soldiers serving in military units. The cross-sectional study was conducted with a total of 313 soldiers stationed in gendarmerie units in a city center in the Central Anatolian Region of Turkey. Data were collected between 01.06.2021 and 31.07.2021 by face-to-face interview technique using Personal Information Form and Fagerström Nicotine Addiction Test. It was determined that 54.6% of the participants smoked, 87.1% had low-moderate nicotine addictions, and 94.9% were smokers in their friends' circle. It was revealed that the prevalence of smoking among the participants was high, and the nicotine addiction levels of the participants working in the "Prison" unit were higher.

确定士兵的吸烟率和尼古丁依赖水平可以作为戒烟干预和制定军事部队士兵吸烟预防政策的指南。这项横断面研究是对驻扎在土耳其中部安纳托利亚地区一个市中心的宪兵队的313名士兵进行的。数据是在2021年6月1日至2021年7月31日期间通过面对面访谈技术收集的,使用个人信息表和Fagerström尼古丁成瘾测试。经测定,54.6%的参与者吸烟,87.1%的参与者有中低尼古丁成瘾,94.9%的参与者在朋友圈吸烟。结果显示,参与者的吸烟率很高,在“监狱”单位工作的参与者的尼古丁成瘾水平更高。
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引用次数: 0
Occupational noise exposure, noise annoyance, hearing-related symptoms, and emotional exhaustion - a participatory-based intervention study in preschool and obstetrics care. 职业性噪声暴露、噪声烦恼、听力相关症状和情绪耗竭——学龄前和产科护理参与性干预研究
Pub Date : 2023-01-01 Epub Date: 2023-12-07 DOI: 10.1080/19338244.2023.2283010
Sofie Fredriksson, Huiqi Li, Mia Söderberg, Kristina Gyllensten, Stephen Widén, Kerstin Persson Waye

A participatory-based intervention was performed in Sweden, aimed at improving the sound environment in one preschool (n = 20) and one obstetric ward (n = 50), with two controls each (n = 28, n = 66). Measured sound levels, and surveys of noise annoyance, hearing-related symptoms and emotional exhaustion were collected before, and three and nine months after the interventions, comparing intervention and control groups over time. The results of this first implementation in a limited number of workplaces showed significantly worsening of hyperacusis, sound-induced auditory fatigue, emotional exhaustion and increased sound levels in the preschool, and worsening of noise annoyance in both intervention groups. Increased risk awareness, limited implementation support and lack of psychosocial interventions may explain the worsening in outcomes, as might the worse baseline in the intervention groups. The complexity of the demands in human-service workplaces calls for further intervention studies.

在瑞典进行了一项参与式干预,旨在改善一个学前班(n = 20)和一个产科病房(n = 50)的声音环境,每个病房有两个对照组(n = 28, n = 66)。在干预前、干预后3个月和9个月收集了测量的声音水平、噪音烦恼、听力相关症状和情绪衰竭的调查,并对干预组和对照组进行了长期比较。在有限数量的工作场所首次实施的结果显示,学龄前儿童的听觉亢进、声音引起的听觉疲劳、情绪疲惫和声音水平增加明显恶化,两个干预组的噪音烦恼都在恶化。风险意识增强、实施支持有限和缺乏心理社会干预可能是导致结果恶化的原因,干预组的基线较差也是原因之一。人性化服务工作场所需求的复杂性需要进一步的干预研究。
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引用次数: 0
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Archives of environmental & occupational health
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