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Cell stem cell最新文献

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The Seed Tends to the Soil: Hair Follicle Stem Cells Remodel Their Lymphatic Niche. 种子走向土壤:毛囊干细胞重塑其淋巴生态位。
Cell stem cell
Pub Date : 2019-12-05 DOI: 10.1016/j.stem.2019.11.009
Denise L. Gay, Mayumi Ito
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引用次数: 1
Heterogeneity within Stratified Epithelial Stem Cell Populations Maintains the Oral Mucosa in Response to Physiological Stress. 分层上皮干细胞群体内的异质性维持口腔粘膜对生理应激的反应。
Cell stem cell
Pub Date : 2019-12-05 DOI: 10.1016/j.stem.2019.11.005
K. Byrd, N. Piehl, Jeet H. Patel, W. J. Huh, I. Sequeira, K. Lough, B. L. Wagner, P. Marangoni, F. Watt, O. Klein, R. Coffey, S. Williams
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引用次数: 34
A 3D Tissue-wide Digital Imaging Pipeline for Quantitation of Secreted Molecules Shows Absence of CXCL12 Gradients in Bone Marrow. 用于定量分泌分子的3D全组织数字成像管道显示骨髓中缺乏CXCL12梯度。
Cell stem cell
Pub Date : 2019-12-05 DOI: 10.1016/j.stem.2019.10.003
L. Kunz, T. Schroeder
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引用次数: 21
Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy. 儿童髓母细胞瘤人源化干细胞模型揭示促进恶性肿瘤的Oct4/mTOR轴
Cell stem cell
Pub Date : 2019-12-05 Epub Date: 2019-11-27 DOI: 10.1016/j.stem.2019.10.005
Matko Čančer, Sonja Hutter, Karl O Holmberg, Gabriela Rosén, Anders Sundström, Jignesh Tailor, Tobias Bergström, Alexandra Garancher, Magnus Essand, Robert J Wechsler-Reya, Anna Falk, Holger Weishaupt, Fredrik J Swartling

Medulloblastoma (MB), the most frequent malignant childhood brain tumor, can arise from cellular malfunctions during hindbrain development. Here we generate humanized models for Sonic Hedgehog (SHH)-subgroup MB via MYCN overexpression in primary human hindbrain-derived neuroepithelial stem (hbNES) cells or iPSC-derived NES cells, which display a range of aggressive phenotypes upon xenografting. iPSC-derived NES tumors develop quickly with leptomeningeal dissemination, whereas hbNES-derived cells exhibit delayed tumor formation with less dissemination. Methylation and expression profiling show that tumors from both origins recapitulate hallmarks of infant SHH MB and reveal that mTOR activation, as a result of increased Oct4, promotes aggressiveness of human SHH tumors. Targeting mTOR decreases cell viability and prolongs survival, showing the utility of these varied models for dissecting mechanisms mediating tumor aggression and demonstrating the value of humanized models for a better understanding of pediatric cancers.

髓母细胞瘤（MB）是最常见的儿童恶性脑肿瘤，可由后脑发育过程中的细胞功能障碍引起。在这里，我们通过MYCN在人后脑来源的神经上皮干细胞（hbNES）细胞或ipsc来源的NES细胞中过表达，建立了Sonic Hedgehog （SHH）亚群MB的人源化模型，这些细胞在异种移植后显示出一系列侵袭性表型。ipsc来源的NES肿瘤发展迅速，伴有轻脑膜播散，而hbnes来源的细胞表现为肿瘤形成延迟，播散较少。甲基化和表达谱显示，两种来源的肿瘤重现了婴儿SHH MB的特征，并揭示了Oct4增加导致mTOR激活，促进了人类SHH肿瘤的侵袭性。靶向mTOR降低细胞活力并延长生存期，显示了这些不同模型在解剖介导肿瘤侵袭机制方面的效用，并证明了人源化模型对更好地了解儿科癌症的价值。
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引用次数: 0
Mutualism in the Marrow. 骨髓中的互惠主义。
Cell stem cell
Pub Date : 2019-12-05 DOI: 10.1016/j.stem.2019.11.007
J. Chute, C. Termini
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引用次数: 0
PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism. PRDM16通过控制区域特异性代谢维持肠上皮稳态。
Cell stem cell
Pub Date : 2019-12-01 DOI: 10.1016/j.stem.2019.08.017
Rachel R. Stine, Alexander Sakers, T. TeSlaa, Megan Kissig, Zachary E. Stine, Chan Wook Kwon, Lan Cheng, Hee-Woong Lim, K. Kaestner, J. Rabinowitz, P. Seale
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引用次数: 49
Identification of Functionally Distinct Mx1+αSMA+ Periosteal Skeletal Stem Cells. 功能不同的Mx1+αSMA+骨膜骨干细胞的鉴定。
Cell stem cell
Pub Date : 2019-12-01 DOI: 10.1016/j.stem.2019.11.003
Laura C. Ortinau, Hamilton Wang, Kevin Lei, Lorenzo Deveza, Youngjae Jeong, Y. Hara, I. Grafe, S. Rosenfeld, Dongjun Lee, Brendan H. Lee, D. Scadden, D. Park
{"title":"Identification of Functionally Distinct Mx1+αSMA+ Periosteal Skeletal Stem Cells.","authors":"Laura C. Ortinau, Hamilton Wang, Kevin Lei, Lorenzo Deveza, Youngjae Jeong, Y. Hara, I. Grafe, S. Rosenfeld, Dongjun Lee, Brendan H. Lee, D. Scadden, D. Park","doi":"10.1016/j.stem.2019.11.003","DOIUrl":"https://doi.org/10.1016/j.stem.2019.11.003","url":null,"abstract":"","PeriodicalId":93928,"journal":{"name":"Cell stem cell","volume":"25 6 1","pages":"784-796.e5"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.stem.2019.11.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46516413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 110
Hic1 Defines Quiescent Mesenchymal Progenitor Subpopulations with Distinct Functions and Fates in Skeletal Muscle Regeneration. Hic1定义了骨骼肌再生中具有不同功能和命运的静止间充质祖细胞亚群。
Cell stem cell
Pub Date : 2019-12-01 DOI: 10.1016/j.stem.2019.11.004
R. W. Scott, Martin Arostegui, R. Schweitzer, F. Rossi, T. Underhill
{"title":"Hic1 Defines Quiescent Mesenchymal Progenitor Subpopulations with Distinct Functions and Fates in Skeletal Muscle Regeneration.","authors":"R. W. Scott, Martin Arostegui, R. Schweitzer, F. Rossi, T. Underhill","doi":"10.1016/j.stem.2019.11.004","DOIUrl":"https://doi.org/10.1016/j.stem.2019.11.004","url":null,"abstract":"","PeriodicalId":93928,"journal":{"name":"Cell stem cell","volume":"25 6 1","pages":"797-813.e9"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.stem.2019.11.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47447319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 108
Apelin+ Endothelial Niche Cells Control Hematopoiesis and Mediate Vascular Regeneration after Myeloablative Injury Apelin+内皮小生境细胞控制造血和介导清髓损伤后血管再生
Cell stem cell
Pub Date : 2019-11-20 DOI: 10.1016/j.stem.2019.10.006
Qi Chen, Yang Liu, H. Jeong, M. Stehling, Van Vuong Dinh, Bin Zhou, R. Adams
{"title":"Apelin+ Endothelial Niche Cells Control Hematopoiesis and Mediate Vascular Regeneration after Myeloablative Injury","authors":"Qi Chen, Yang Liu, H. Jeong, M. Stehling, Van Vuong Dinh, Bin Zhou, R. Adams","doi":"10.1016/j.stem.2019.10.006","DOIUrl":"https://doi.org/10.1016/j.stem.2019.10.006","url":null,"abstract":"","PeriodicalId":93928,"journal":{"name":"Cell stem cell","volume":"25 1","pages":"768 - 783.e6"},"PeriodicalIF":0.0,"publicationDate":"2019-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.stem.2019.10.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42025546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 82
Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer. 患者来源的类器官预测局部晚期癌症的化学放射反应。
Cell stem cell
Pub Date : 2019-11-19 DOI: 10.1016/j.stem.2019.10.010
Ye Yao, Xiaoya Xu, Li-feng Yang, Ji Zhu, J. Wan, L. Shen, F. Xia, G. Fu, Yun Deng, M. Pan, Q. Guo, Xiaoxue Gao, Yuanchuang Li, X. Rao, Yi Zhou, L. Liang, Yaqi Wang, Jing Zhang, Hui Zhang, G. Li, Lixing Zhang, J. Peng, S. Cai, Chen Hu, Jianjun Gao, H. Clevers, Zhen Zhang, Guoqiang Hua
{"title":"Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer.","authors":"Ye Yao, Xiaoya Xu, Li-feng Yang, Ji Zhu, J. Wan, L. Shen, F. Xia, G. Fu, Yun Deng, M. Pan, Q. Guo, Xiaoxue Gao, Yuanchuang Li, X. Rao, Yi Zhou, L. Liang, Yaqi Wang, Jing Zhang, Hui Zhang, G. Li, Lixing Zhang, J. Peng, S. Cai, Chen Hu, Jianjun Gao, H. Clevers, Zhen Zhang, Guoqiang Hua","doi":"10.1016/j.stem.2019.10.010","DOIUrl":"https://doi.org/10.1016/j.stem.2019.10.010","url":null,"abstract":"","PeriodicalId":93928,"journal":{"name":"Cell stem cell","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.stem.2019.10.010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47859261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 335
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