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An oncogenic enhancer encodes selective selenium dependency in AML. 一种致癌增强子编码AML中的选择性硒依赖性。
Cell stem cell
Pub Date : 2022-04-01 DOI: 10.1016/j.stem.2022.03.006
Kenneth Eagle, Yajian Jiang, Xiangguo Shi, Minhua Li, N. Obholzer, T. Hu, Monika W Perez, Jošt Vrabič Koren, A. Kitano, Joanna S. Yi, Charles Y. Lin, Daisuke Nakada
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引用次数: 1
c-Maf: The magic wand that turns on LSEC fate. c-Maf：开启LSEC命运的魔杖。
Cell stem cell
Pub Date : 2022-04-01 DOI: 10.1016/j.stem.2022.03.011
Anna R. Smith, V. Gouon-Evans
{"title":"c-Maf: The magic wand that turns on LSEC fate.","authors":"Anna R. Smith, V. Gouon-Evans","doi":"10.1016/j.stem.2022.03.011","DOIUrl":"https://doi.org/10.1016/j.stem.2022.03.011","url":null,"abstract":"","PeriodicalId":93928,"journal":{"name":"Cell stem cell","volume":"78 ","pages":"491-493"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41273883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Successful organoid-mediated generation of iPSC-derived CAR-T cells. 类器官介导的ipsc衍生CAR-T细胞的成功生成。
Cell stem cell
Pub Date : 2022-04-01 DOI: 10.1016/j.stem.2022.03.005
S. Kaneko
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引用次数: 10
8C-like cells capture the human zygotic genome activation program in vitro. 8c样细胞在体外捕获人类合子基因组激活程序
Cell stem cell
Pub Date : 2022-03-03 Epub Date: 2022-02-24 DOI: 10.1016/j.stem.2022.01.014
Jasmin Taubenschmid-Stowers, Maria Rostovskaya, Fátima Santos, Sebastian Ljung, Ricard Argelaguet, Felix Krueger, Jennifer Nichols, Wolf Reik

The activation of the embryonic genome marks the first major wave of transcription in the developing organism. Zygotic genome activation (ZGA) in mouse 2-cell embryos and 8-cell embryos in humans is crucial for development. Here, we report the discovery of human 8-cell-like cells (8CLCs) among naive embryonic stem cells, which transcriptionally resemble the 8-cell human embryo. They express ZGA markers, including ZSCAN4 and LEUTX, and transposable elements, such as HERVL and MLT2A1. 8CLCs show reduced SOX2 levels and can be identified using TPRX1 and H3.Y marker proteins in vitro. Overexpression of the transcription factor DUX4 and spliceosome inhibition increase human ZGA-like transcription. Excitingly, the 8CLC markers TPRX1 and H3.Y are also expressed in ZGA-stage 8-cell human embryos and may thus be relevant in vivo. 8CLCs provide a unique opportunity to characterize human ZGA-like transcription and might provide critical insights into early events in embryogenesis in humans.

胚胎基因组的激活标志着发育中生物体的第一波主要转录。小鼠2细胞胚胎和人类8细胞胚胎的子代基因组激活（ZGA）对发育至关重要。在这里，我们报告了在天真胚胎干细胞中发现的人类8细胞样细胞（8CLCs），它们在转录上类似于人类的8细胞胚胎。它们表达ZGA标记，包括ZSCAN4和LEUTX，以及转座元件，如HERVL和MLT2A1。8CLCs 的 SOX2 水平降低，可通过体外 TPRX1 和 H3.Y 标记蛋白进行识别。转录因子 DUX4 的过表达和剪接体抑制会增加人类 ZGA 样转录。令人兴奋的是，8CLC 标记蛋白 TPRX1 和 H3.Y 也在 ZGA 阶段的 8 细胞人类胚胎中表达，因此可能与体内相关。8CLC 为描述人类 ZGA 样转录提供了一个独特的机会，并可能为人类胚胎发生的早期事件提供重要的见解。
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引用次数: 0
Human biliary epithelial cells for regenerative medicine. 用于再生医学的人胆道上皮细胞。
Cell stem cell
Pub Date : 2022-03-01 DOI: 10.1016/j.stem.2022.02.001
Saloni Sinha, R. Schwartz
{"title":"Human biliary epithelial cells for regenerative medicine.","authors":"Saloni Sinha, R. Schwartz","doi":"10.1016/j.stem.2022.02.001","DOIUrl":"https://doi.org/10.1016/j.stem.2022.02.001","url":null,"abstract":"","PeriodicalId":93928,"journal":{"name":"Cell stem cell","volume":"29 3 1","pages":"345-347"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41449483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SEPHguarding acute myeloid leukemia. SEPH预防急性粒细胞白血病。
Cell stem cell
Pub Date : 2022-03-01 DOI: 10.1016/j.stem.2022.02.007
M. Gupta, B. Will
{"title":"SEPHguarding acute myeloid leukemia.","authors":"M. Gupta, B. Will","doi":"10.1016/j.stem.2022.02.007","DOIUrl":"https://doi.org/10.1016/j.stem.2022.02.007","url":null,"abstract":"","PeriodicalId":93928,"journal":{"name":"Cell stem cell","volume":"29 3 1","pages":"350-352"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45373373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Cone photoreceptors in human stem cell-derived retinal organoids demonstrate intrinsic light responses that mimic those of primate fovea. 人类干细胞衍生视网膜类器官的视锥光感受器表现出模仿灵长类动物中央凹的内在光反应。
Cell stem cell
Pub Date : 2022-03-01 DOI: 10.1016/j.stem.2022.02.003
Aindrila Saha, E. Capowski, Maria A Fernandez Zepeda, Emma C Nelson, D. Gamm, Raunak Sinha
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引用次数: 5
Video, ergo sum: The search for response to natural light. 视频，ergo sum:寻找对自然光的反应。
Cell stem cell
Pub Date : 2022-03-01 DOI: 10.1016/j.stem.2022.02.005
Juan M. Angueyra, Wei Li
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引用次数: 1
Human 8-cell-like cells discovered. 发现人类8细胞样细胞。
Cell stem cell
Pub Date : 2022-03-01 DOI: 10.1016/j.stem.2022.01.015
Bradley P. Balaton, V. Pasque
{"title":"Human 8-cell-like cells discovered.","authors":"Bradley P. Balaton, V. Pasque","doi":"10.1016/j.stem.2022.01.015","DOIUrl":"https://doi.org/10.1016/j.stem.2022.01.015","url":null,"abstract":"","PeriodicalId":93928,"journal":{"name":"Cell stem cell","volume":"29 3 1","pages":"347-348"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43165390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
T cell immunotherapy for cardiac fibrosis: mRNA starts the CAR. T细胞免疫治疗心脏纤维化：信使核糖核酸启动CAR。
Cell stem cell
Pub Date : 2022-03-01 DOI: 10.1016/j.stem.2022.02.002
Ronald J. Vagnozzi, T. McKinsey
{"title":"T cell immunotherapy for cardiac fibrosis: mRNA starts the CAR.","authors":"Ronald J. Vagnozzi, T. McKinsey","doi":"10.1016/j.stem.2022.02.002","DOIUrl":"https://doi.org/10.1016/j.stem.2022.02.002","url":null,"abstract":"","PeriodicalId":93928,"journal":{"name":"Cell stem cell","volume":"29 3 1","pages":"352-354"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42958307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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