Pub Date : 2026-01-09eCollection Date: 2026-01-01DOI: 10.1093/haschl/qxag002
Jenny S Guadamuz, Stacy Chen, Arturo Vargas Bustamante
Introduction: California's 4.8 million noncitizen adults, half of whom are undocumented, endure substantial exclusions from health care. To address this gap, California policymakers expanded full-scope, state-funded Medicaid without discriminating by immigration status, first extending coverage to undocumented young adults (18-25 years) in 2020 and then to older adults (≥50 years) in 2022.
Methods: Using the American Community Survey (2017-2023), we assessed whether California's Medicaid expansion for young and older undocumented adults was associated with changes in insurance coverage by comparing pre- and post-expansion differences between citizens and noncitizens (difference-in-differences).
Results: Compared to citizens, the expansion was not associated with increased health insurance or Medicaid enrollment among young noncitizens. However, among older adults, the expansion was associated with a modest 1.3% increase in overall insurance coverage for noncitizens, including a 2.4% increase in Medicaid. Following these expansions, noncitizens remain significantly less likely to have insurance: 28% of young noncitizens and 16% of older noncitizens lack coverage, compared to 8% and 3% for young and older citizens, respectively.
Conclusion: Given these persistent inequities-where noncitizens across nearly all sociodemographic factors are less likely to be insured-preserving and strengthening the existing pathways to insurance coverage for noncitizens, including undocumented immigrants, remains critical.
{"title":"Medicaid expansion for undocumented adults and its association with health insurance coverage among noncitizens in California, 2017-2023.","authors":"Jenny S Guadamuz, Stacy Chen, Arturo Vargas Bustamante","doi":"10.1093/haschl/qxag002","DOIUrl":"10.1093/haschl/qxag002","url":null,"abstract":"<p><strong>Introduction: </strong>California's 4.8 million noncitizen adults, half of whom are undocumented, endure substantial exclusions from health care. To address this gap, California policymakers expanded full-scope, state-funded Medicaid without discriminating by immigration status, first extending coverage to undocumented young adults (18-25 years) in 2020 and then to older adults (≥50 years) in 2022.</p><p><strong>Methods: </strong>Using the American Community Survey (2017-2023), we assessed whether California's Medicaid expansion for young and older undocumented adults was associated with changes in insurance coverage by comparing pre- and post-expansion differences between citizens and noncitizens (difference-in-differences).</p><p><strong>Results: </strong>Compared to citizens, the expansion was not associated with increased health insurance or Medicaid enrollment among young noncitizens. However, among older adults, the expansion was associated with a modest 1.3% increase in overall insurance coverage for noncitizens, including a 2.4% increase in Medicaid. Following these expansions, noncitizens remain significantly less likely to have insurance: 28% of young noncitizens and 16% of older noncitizens lack coverage, compared to 8% and 3% for young and older citizens, respectively.</p><p><strong>Conclusion: </strong>Given these persistent inequities-where noncitizens across nearly all sociodemographic factors are less likely to be insured-preserving and strengthening the existing pathways to insurance coverage for noncitizens, including undocumented immigrants, remains critical.</p>","PeriodicalId":94025,"journal":{"name":"Health affairs scholar","volume":"4 1","pages":"qxag002"},"PeriodicalIF":2.7,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12849358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146088392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-08eCollection Date: 2026-01-01DOI: 10.1093/haschl/qxaf253
John M Westfall, Linda Zittleman, Camille Hochheimer, David Wolff, Doug Fernald, Ben Sofie, Cory Lutgen, L Miriam Dickinson, Donald E Nease, The Homer Patient And Clinician Advisory Council
Context: Changes in regulations related to medication for opioid use disorder (MOUD) have expanded access to MOUD in primary care. However, there has been concern that primary care practices are unwilling or unable to treat patients with OUD.
Objective: To describe the practices and patients enrolled in the Patient-Centered Outcomes Research Institute (PCORI)-funded HOMER (Comparing Home, Office, and Telehealth Induction for Medication Enhanced Recovery) research study who delivered MOUD as part of routine primary care practice.
Results: A total of 79 practices from 25 states expressed interest in participation. Sixty-two practices signed up for HOMER. Practices were typical of US primary care, accepting a variety of payers, including commercial insurance, Medicaid, Medicare, and uninsured patients, and caring for patients of across a spectrum of adult ages, races and ethnicity, education, and income. The majority had health insurance (82%). Most patients reported using prescription opioids (59%), while 41% reported other opioid use. Greater than 40% of participating patients reported no prior medication treatment for OUD.
Conclusion: The finding that nearly half of patients had no prior treatment supports the importance of primary care as a crucial component of MOUD. Practices in HOMER were similar to practices across the country. Patients enrolled were typical of family practice patients. Policies that support primary care MOUD may improve access to patients.
{"title":"Primary care provides medication for opioid use disorder: findings from the HOMER study.","authors":"John M Westfall, Linda Zittleman, Camille Hochheimer, David Wolff, Doug Fernald, Ben Sofie, Cory Lutgen, L Miriam Dickinson, Donald E Nease, The Homer Patient And Clinician Advisory Council","doi":"10.1093/haschl/qxaf253","DOIUrl":"https://doi.org/10.1093/haschl/qxaf253","url":null,"abstract":"<p><strong>Context: </strong>Changes in regulations related to medication for opioid use disorder (MOUD) have expanded access to MOUD in primary care. However, there has been concern that primary care practices are unwilling or unable to treat patients with OUD.</p><p><strong>Objective: </strong>To describe the practices and patients enrolled in the Patient-Centered Outcomes Research Institute (PCORI)-funded HOMER (Comparing Home, Office, and Telehealth Induction for Medication Enhanced Recovery) research study who delivered MOUD as part of routine primary care practice.</p><p><strong>Results: </strong>A total of 79 practices from 25 states expressed interest in participation. Sixty-two practices signed up for HOMER. Practices were typical of US primary care, accepting a variety of payers, including commercial insurance, Medicaid, Medicare, and uninsured patients, and caring for patients of across a spectrum of adult ages, races and ethnicity, education, and income. The majority had health insurance (82%). Most patients reported using prescription opioids (59%), while 41% reported other opioid use. Greater than 40% of participating patients reported no prior medication treatment for OUD.</p><p><strong>Conclusion: </strong>The finding that nearly half of patients had no prior treatment supports the importance of primary care as a crucial component of MOUD. Practices in HOMER were similar to practices across the country. Patients enrolled were typical of family practice patients. Policies that support primary care MOUD may improve access to patients.</p>","PeriodicalId":94025,"journal":{"name":"Health affairs scholar","volume":"4 1","pages":"qxaf253"},"PeriodicalIF":2.7,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12835562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146095212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-30eCollection Date: 2026-01-01DOI: 10.1093/haschl/qxaf249
Nicole Kravitz-Wirtz, Julia J Lund, Amanda J Aubel, Aaron B Shev, Garen J Wintemute
Introduction: Firearm-related injuries cause far-reaching harm, yet information about the value the public assigns to the benefits of prevention is limited.
Methods: We surveyed California adults from the Ipsos KnowledgePanel (N = 2870) about their willingness to pay (WTP), in taxes or donations, to prevent firearm homicides, firearm suicides, and deaths from mass shootings. WTP was calculated using a double-bounded dichotomous choice contingent valuation model with a log-logistic error distribution.
Results: The mean WTP estimate for a program preventing 1 in 10 deaths ranged from $85.16 annually in donations to prevent firearm suicides to $145.63 in additional taxes to prevent deaths from mass shootings. In general, firearm owners were willing to pay less than non-owners; however, Black firearm owners reported the largest WTP, among subgroups and overall. Most respondents were willing to pay the sum-total of their bids to prevent all 3 types of firearm injury; of those, maximum WTP, on average, was $508.08 annually in donations or $534.82 in additional taxes. This implies a statewide total of up to $6.9 billion in perceived benefit.
Conclusion: As resources for prevention, intervention, and supportive services are threatened or terminated, these findings underscore the substantial public demand for investments in firearm injury reduction efforts.
{"title":"Preventing firearm-related deaths and the public good: a contingent valuation study in California.","authors":"Nicole Kravitz-Wirtz, Julia J Lund, Amanda J Aubel, Aaron B Shev, Garen J Wintemute","doi":"10.1093/haschl/qxaf249","DOIUrl":"10.1093/haschl/qxaf249","url":null,"abstract":"<p><strong>Introduction: </strong>Firearm-related injuries cause far-reaching harm, yet information about the value the public assigns to the benefits of prevention is limited.</p><p><strong>Methods: </strong>We surveyed California adults from the Ipsos KnowledgePanel (<i>N</i> = 2870) about their willingness to pay (WTP), in taxes or donations, to prevent firearm homicides, firearm suicides, and deaths from mass shootings. WTP was calculated using a double-bounded dichotomous choice contingent valuation model with a log-logistic error distribution.</p><p><strong>Results: </strong>The mean WTP estimate for a program preventing 1 in 10 deaths ranged from $85.16 annually in donations to prevent firearm suicides to $145.63 in additional taxes to prevent deaths from mass shootings. In general, firearm owners were willing to pay less than non-owners; however, Black firearm owners reported the largest WTP, among subgroups and overall. Most respondents were willing to pay the sum-total of their bids to prevent all 3 types of firearm injury; of those, maximum WTP, on average, was $508.08 annually in donations or $534.82 in additional taxes. This implies a statewide total of up to $6.9 billion in perceived benefit.</p><p><strong>Conclusion: </strong>As resources for prevention, intervention, and supportive services are threatened or terminated, these findings underscore the substantial public demand for investments in firearm injury reduction efforts.</p>","PeriodicalId":94025,"journal":{"name":"Health affairs scholar","volume":"4 1","pages":"qxaf249"},"PeriodicalIF":2.7,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12796804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145971741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-30eCollection Date: 2026-01-01DOI: 10.1093/haschl/qxaf251
Elena Andreyeva, Eleena Koep, Protima Advani, Glenn Melnick
{"title":"Decomposition of trauma care prices between 2019 and 2022 in the US commercially insured population.","authors":"Elena Andreyeva, Eleena Koep, Protima Advani, Glenn Melnick","doi":"10.1093/haschl/qxaf251","DOIUrl":"10.1093/haschl/qxaf251","url":null,"abstract":"","PeriodicalId":94025,"journal":{"name":"Health affairs scholar","volume":"4 1","pages":"qxaf251"},"PeriodicalIF":2.7,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12798801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145971737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-30eCollection Date: 2026-01-01DOI: 10.1093/haschl/qxaf254
Neeraj G Patel, Reshma Ramachandran, Joseph S Ross
The federal government and several states have implemented measures to restrict, ban, and increase transparency of promotional payments from pharmaceutical companies to clinicians who prescribe medications. In 2018, New Jersey adopted a novel rule that included a $10 000 restriction on aggregate annual prescriber compensation for promotional speaking, advisory board participation, and consulting arrangements. In this study, we estimated changes associated with the restriction by comparing payments made to physicians in New Jersey to those in a comparator state, Pennsylvania, where no such rule exists. We found that the New Jersey restriction was associated with no significant difference in the proportion of physicians receiving aggregate honoraria and consulting payments above $10 000 annually as compared to physicians in Pennsylvania. Further research is needed to better understand the effect of state policies restricting pharmaceutical industry payments to prescribers.
{"title":"Changes in pharmaceutical industry payments to physicians after New Jersey's 2018 restriction.","authors":"Neeraj G Patel, Reshma Ramachandran, Joseph S Ross","doi":"10.1093/haschl/qxaf254","DOIUrl":"10.1093/haschl/qxaf254","url":null,"abstract":"<p><p>The federal government and several states have implemented measures to restrict, ban, and increase transparency of promotional payments from pharmaceutical companies to clinicians who prescribe medications. In 2018, New Jersey adopted a novel rule that included a $10 000 restriction on aggregate annual prescriber compensation for promotional speaking, advisory board participation, and consulting arrangements. In this study, we estimated changes associated with the restriction by comparing payments made to physicians in New Jersey to those in a comparator state, Pennsylvania, where no such rule exists. We found that the New Jersey restriction was associated with no significant difference in the proportion of physicians receiving aggregate honoraria and consulting payments above $10 000 annually as compared to physicians in Pennsylvania. Further research is needed to better understand the effect of state policies restricting pharmaceutical industry payments to prescribers.</p>","PeriodicalId":94025,"journal":{"name":"Health affairs scholar","volume":"4 1","pages":"qxaf254"},"PeriodicalIF":2.7,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12798812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145971728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-24eCollection Date: 2026-01-01DOI: 10.1093/haschl/qxaf246
Katherine E M Miller, Jennifer L Wolff, Brian C Castrucci, Sandro Galea, Catherine K Ettman
Introduction: Record numbers of Americans are living with serious illness and disability. Increasingly, older adults and persons with disability will be responsible for managing and financing their care needs into older age, putting more onus on individuals and their families to arrange care. Understanding the current and expected caregiving landscape can inform efforts to prepare for future population needs.
Methods: We used nationally representative survey data collected in Spring 2025 (N = 2020) to estimate the prevalence of past, current, and expected future caregiving and examine the association of sociodemographic characteristics and caregiving responsibilities using logistic regression.
Results: We found that one in four U.S. adults reported caregiving within the last year, and most (60%) expected future caregiving responsibilities, corresponding to over 155 million adults. After adjusting for socioeconomic characteristics, the strongest positive predictors of expected caregiving were prior or current caregiving experiences. We found no significant difference in anticipated future caregiving across political ideology.
Conclusion: Our findings collectively underscore the universality of caregiving, and, within the context of scarce long-term care insurance uptake and declining funding for Medicaid, amplify the importance of scaling policies that support current and future family caregivers who provide the bulk of long-term care in the United States.
{"title":"A nation of caregivers: past, present, and future expectations of caregiving.","authors":"Katherine E M Miller, Jennifer L Wolff, Brian C Castrucci, Sandro Galea, Catherine K Ettman","doi":"10.1093/haschl/qxaf246","DOIUrl":"10.1093/haschl/qxaf246","url":null,"abstract":"<p><strong>Introduction: </strong>Record numbers of Americans are living with serious illness and disability. Increasingly, older adults and persons with disability will be responsible for managing and financing their care needs into older age, putting more onus on individuals and their families to arrange care. Understanding the current and expected caregiving landscape can inform efforts to prepare for future population needs.</p><p><strong>Methods: </strong>We used nationally representative survey data collected in Spring 2025 (<i>N</i> = 2020) to estimate the prevalence of past, current, and expected future caregiving and examine the association of sociodemographic characteristics and caregiving responsibilities using logistic regression.</p><p><strong>Results: </strong>We found that one in four U.S. adults reported caregiving within the last year, and most (60%) expected future caregiving responsibilities, corresponding to over 155 million adults. After adjusting for socioeconomic characteristics, the strongest positive predictors of expected caregiving were prior or current caregiving experiences. We found no significant difference in anticipated future caregiving across political ideology.</p><p><strong>Conclusion: </strong>Our findings collectively underscore the universality of caregiving, and, within the context of scarce long-term care insurance uptake and declining funding for Medicaid, amplify the importance of scaling policies that support current and future family caregivers who provide the bulk of long-term care in the United States.</p>","PeriodicalId":94025,"journal":{"name":"Health affairs scholar","volume":"4 1","pages":"qxaf246"},"PeriodicalIF":2.7,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12778324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-24eCollection Date: 2026-01-01DOI: 10.1093/haschl/qxaf248
Hannah T Neprash, John F Mulcahy
{"title":"The cost of indirect billing for traditional Medicare beneficiaries.","authors":"Hannah T Neprash, John F Mulcahy","doi":"10.1093/haschl/qxaf248","DOIUrl":"10.1093/haschl/qxaf248","url":null,"abstract":"","PeriodicalId":94025,"journal":{"name":"Health affairs scholar","volume":"4 1","pages":"qxaf248"},"PeriodicalIF":2.7,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12778422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-23eCollection Date: 2025-12-01DOI: 10.1093/haschl/qxaf233
Xianqun Luan, Brian T Fisher, Susan E Coffin, David Rubin, Meredith Matone, Jing Huang
Introduction: K-12 schools are not only educational settings but also hubs of social interaction, making them potential drivers of disease transmission within households and communities. While many existing studies have assessed school masking in relation to in-school transmission, the broader community impact of mandatory school masking policies on SARS-CoV-2 infection rates remains poorly understood.
Methods: We conducted a retrospective quasi-experimental study using the synthetic control method to evaluate the association between masking policies and community infection rates during the fall 2021 US school reopening period, when most schools returned to in-person learning but masking policies varied substantially. Analyses accounted for community characteristics prior to reopening and baseline infection rates.
Results: Counties with mandatory school masking experienced significantly lower SARS-CoV-2 infection rates than those without mandates. In the first 9 weeks after reopening, mandatory masking was associated with 820 fewer cases per 100 000 people (95% CI: 444-1185), corresponding to a relative cumulative reduction of 9.4% (95% CI: 7.3%-11.8%). The strength of this association varied by baseline infection rates, population density, and mobility patterns.
Conclusion: Mandatory school masking policies were linked to meaningful reductions in community SARS-CoV-2 transmission and underscore their value as a public health intervention during pandemic surges.
{"title":"School masking and COVID-19 community transmission: a synthetic control study.","authors":"Xianqun Luan, Brian T Fisher, Susan E Coffin, David Rubin, Meredith Matone, Jing Huang","doi":"10.1093/haschl/qxaf233","DOIUrl":"10.1093/haschl/qxaf233","url":null,"abstract":"<p><strong>Introduction: </strong>K-12 schools are not only educational settings but also hubs of social interaction, making them potential drivers of disease transmission within households and communities. While many existing studies have assessed school masking in relation to in-school transmission, the broader community impact of mandatory school masking policies on SARS-CoV-2 infection rates remains poorly understood.</p><p><strong>Methods: </strong>We conducted a retrospective quasi-experimental study using the synthetic control method to evaluate the association between masking policies and community infection rates during the fall 2021 US school reopening period, when most schools returned to in-person learning but masking policies varied substantially. Analyses accounted for community characteristics prior to reopening and baseline infection rates.</p><p><strong>Results: </strong>Counties with mandatory school masking experienced significantly lower SARS-CoV-2 infection rates than those without mandates. In the first 9 weeks after reopening, mandatory masking was associated with 820 fewer cases per 100 000 people (95% CI: 444-1185), corresponding to a relative cumulative reduction of 9.4% (95% CI: 7.3%-11.8%). The strength of this association varied by baseline infection rates, population density, and mobility patterns.</p><p><strong>Conclusion: </strong>Mandatory school masking policies were linked to meaningful reductions in community SARS-CoV-2 transmission and underscore their value as a public health intervention during pandemic surges.</p>","PeriodicalId":94025,"journal":{"name":"Health affairs scholar","volume":"3 12","pages":"qxaf233"},"PeriodicalIF":2.7,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12723219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145828878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-23eCollection Date: 2026-02-01DOI: 10.1093/haschl/qxaf247
Mariana P Socal, Yunxiang Sun, Jeromie Ballreich, Joy Acha, Mohammad Ali Yazdi, Tinglong Dai, Maqbool Dada
Introduction: The impact of tariffs on prescription drug prices has been poorly understood.
Methods: Using US importation data 2019-2024, this study modeled the potential impact of tariffs on the prices of generic drugs manufactured in the United States with imported active pharmaceutical ingredients (APIs).
Results: Under baseline assumptions a 100% worldwide tariff would result in average price increase of 30% (additional $21.15 per prescription) and a blended tariff based on rates proposed by the Federal Administration would result in an average price increase of 10% (additional $6.22 per prescription) for domestically produced generics using imported APIs. Estimates varied across drugs reflecting different API importation patterns. Assumptions on the tariff rate, the contribution of the API cost to the final drug price, and on the supply chain's ability to absorb the added tariff contributed markedly to determining the final price. The study findings do not generalize to US-made generics using US-made APIs but could be relevant to US-made branded drugs using imported APIs.
Conclusion: Tariffs could raise costs for US drug manufacturers using imported APIs, potentially limiting affordability and manufacturers' competitiveness in United States and global markets. Policies to incentivize "made-in-America" prescription drugs should incentivize domestic API production or reconsider API tariffs.
{"title":"Potential impact of tariffs on active pharmaceutical ingredients on the price of US-made generic drugs.","authors":"Mariana P Socal, Yunxiang Sun, Jeromie Ballreich, Joy Acha, Mohammad Ali Yazdi, Tinglong Dai, Maqbool Dada","doi":"10.1093/haschl/qxaf247","DOIUrl":"10.1093/haschl/qxaf247","url":null,"abstract":"<p><strong>Introduction: </strong>The impact of tariffs on prescription drug prices has been poorly understood.</p><p><strong>Methods: </strong>Using US importation data 2019-2024, this study modeled the potential impact of tariffs on the prices of generic drugs manufactured in the United States with imported active pharmaceutical ingredients (APIs).</p><p><strong>Results: </strong>Under baseline assumptions a 100% worldwide tariff would result in average price increase of 30% (additional $21.15 per prescription) and a blended tariff based on rates proposed by the Federal Administration would result in an average price increase of 10% (additional $6.22 per prescription) for domestically produced generics using imported APIs. Estimates varied across drugs reflecting different API importation patterns. Assumptions on the tariff rate, the contribution of the API cost to the final drug price, and on the supply chain's ability to absorb the added tariff contributed markedly to determining the final price. The study findings do not generalize to US-made generics using US-made APIs but could be relevant to US-made branded drugs using imported APIs.</p><p><strong>Conclusion: </strong>Tariffs could raise costs for US drug manufacturers using imported APIs, potentially limiting affordability and manufacturers' competitiveness in United States and global markets. Policies to incentivize \"made-in-America\" prescription drugs should incentivize domestic API production or reconsider API tariffs.</p>","PeriodicalId":94025,"journal":{"name":"Health affairs scholar","volume":"4 2","pages":"qxaf247"},"PeriodicalIF":2.7,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12868979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-23eCollection Date: 2026-01-01DOI: 10.1093/haschl/qxaf243
Carolyn Sun, Shakib Hossain, Shannon L Harris
The proliferation of Artificial Intelligence (AI) technologies, fueled by advancements in computational power and generative models, is rapidly reshaping healthcare delivery and research. However, the absence of a standardized definition of AI impedes regulatory development, confounds public discourse, and hinders clinical adoption. This study provides clarity for AI developers and users in terminology surrounding the topic, which will ultimately assist in mitigating risks to patients and the public. Utilizing a multiphase Delphi method involving international informatics experts, we synthesized existing definitions and facilitated consensus on an operational definition of AI tailored to healthcare contexts. Our findings aim to establish a foundational framework to guide ethical governance, promote funding alignment, and optimize AI integration in clinical settings.
{"title":"Toward an operational definition of Artificial Intelligence for health care informatics: a Delphi survey.","authors":"Carolyn Sun, Shakib Hossain, Shannon L Harris","doi":"10.1093/haschl/qxaf243","DOIUrl":"10.1093/haschl/qxaf243","url":null,"abstract":"<p><p>The proliferation of Artificial Intelligence (AI) technologies, fueled by advancements in computational power and generative models, is rapidly reshaping healthcare delivery and research. However, the absence of a standardized definition of AI impedes regulatory development, confounds public discourse, and hinders clinical adoption. This study provides clarity for AI developers and users in terminology surrounding the topic, which will ultimately assist in mitigating risks to patients and the public. Utilizing a multiphase Delphi method involving international informatics experts, we synthesized existing definitions and facilitated consensus on an operational definition of AI tailored to healthcare contexts. Our findings aim to establish a foundational framework to guide ethical governance, promote funding alignment, and optimize AI integration in clinical settings.</p>","PeriodicalId":94025,"journal":{"name":"Health affairs scholar","volume":"4 1","pages":"qxaf243"},"PeriodicalIF":2.7,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12778320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}