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Cardiac migration of an implanted hepatic fiducial marker used for stereotactic body radiation therapy - A case report. 用于立体定向体放射治疗的植入式肝脏靶标的心脏移位--病例报告。
Pub Date : 2024-07-01 Epub Date: 2024-01-22 DOI: 10.4103/jcrt.jcrt_2654_22
Youstina Soliman, Febin Antony, Mark Vivian, Sankar Venkatraman, Maged Nashed

Abstract: Stereotactic body radiation therapy (SBRT) has been increasingly used to treat liver malignancies because large doses of radiation can be delivered precisely to the target with a rapid dose falloff. Real-time tracking of implanted fiducial markers (FMs), combined with respiratory gating, further improves the accuracy of treatment delivery and reduces the dose to critical structures. There have been reports of migration of the FMs after implantation for SBRT. Calypso beacons, which use the electromagnetic wave reflections for the image guidance, have recently been used for image-guided liver SBRT. In the literature, there are no reports on the migration of Calypso beacons to the heart after implantation in the liver. In this report, we detail the first case of such migration. Respiratory-gated SBRT guided by the Calypso system was planned for our patient, who developed liver metastases in segments 6 and 5/4B shortly after the completion of radical chemoradiotherapy for anal squamous cell carcinoma. One of the three Calypso beacons inserted in the liver under computed tomography (CT) guidance was found to have migrated to the right ventricle, as seen in CT simulation images. SBRT was delivered with respiratory gating using the remaining two beacons. A fluoroscopic imaging performed during treatment confirmed the migrated marker to the right ventricle. Patient denied any cardiac symptoms and SBRT were delivered uneventfully. Ten months later, the patient died of disease progression.

摘要:立体定向体放射治疗(SBRT)可将大剂量放射线精确送达靶点,且剂量衰减迅速,因此越来越多地用于治疗肝脏恶性肿瘤。植入靶标(FMs)的实时跟踪与呼吸门控相结合,进一步提高了治疗的准确性,并降低了关键结构的剂量。曾有报道称,SBRT 植入靶标后会发生迁移。利用电磁波反射进行图像引导的Calypso信标最近被用于图像引导下的肝脏SBRT。在文献中,还没有关于 Calypso 信号信标植入肝脏后迁移到心脏的报道。在本报告中,我们详细介绍了首例此类迁移病例。我们的患者在完成肛门鳞状细胞癌根治性化疗后不久,出现了肝脏第6和第5/4B节段的转移。在计算机断层扫描(CT)引导下插入肝脏的三个 Calypso 信标中,有一个被发现已移至右心室,这在 CT 模拟图像中可以看到。使用其余两个信标在呼吸门控下进行了 SBRT 治疗。在治疗过程中进行的透视成像证实了标记已移至右心室。患者否认有任何心脏症状,SBRT 顺利进行。十个月后,患者死于疾病进展。
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引用次数: 0
Pattern of care and clinical outcome of patients with carcinoma endometrium and the impact of central histopathological review on management: A tertiary cancer centre experience. 子宫内膜癌患者的护理模式和临床结果以及中央组织病理学审查对管理的影响:三级癌症中心的经验。
Pub Date : 2024-07-01 Epub Date: 2024-09-19 DOI: 10.4103/jcrt.jcrt_1207_23
Rakhi Verma, Ajeet K Gandhi, Madhup Rastogi, Vachaspati K Mishra, Vikas Sharma, Akash Agarwal, Saumya Shukla, Rohini Khurana, Rahat Hadi, Anoop K Srivastava, Nuzhat Husain

Purpose/objective: Endometrial carcinoma (EC) is the third most common gynecological malignancy in India. Recent PORTEC-3 analysis emphasized the role of central histopathological review. We aimed to retrospectively analyze the demographic and histopathological characteristics of EC patients treated at our institute and assess the impact of the central histopathological review on management and also analyze clinical outcomes in this cohort of patients.

Materials and methods: Data of 75 EC patients treated at our center between 2013 and 2022 were retrieved from our departmental archives. Patients were analyzed for demographic details, histopathological findings, details of surgery and histopathology (HPE), results of a review of HPE, adjuvant treatment details, and clinical outcomes. All patients with HPE outside of our institute were reviewed at our center prior to initiation of treatment. In cases of discordance, patients were discussed in the multidisciplinary tumor board for the final treatment decisions. Patients were staged as per International Federation of Gynaecology and Obstetrics 2018.

Result: The median age was 57 years (range: 37-74 years). Twenty-seven patients with HPE reported from the outside center were reviewed at our institute and changes were observed in 26 patients (96.3%). HPE review changes were observed in terms of histological grade, histological type, myometrial invasion, and lymph node involvement in five (18.5%), three (11.1%), seven (25.9%), and three (42.8%), respectively. HPE review leads to changes in the management of 19/26 patients. Stage distribution was I: II: III in 48 (64%): 9 (13.3%): 18 (24%) patients, respectively. The median external beam radiotherapy dose was 50 Gray (range: 45-50.4 Gray at 1.8-2 Gray per fraction). The median brachytherapy dose for patients treated with brachytherapy alone was 7 Gray each for three sessions and in combination with EBRT was 6 Gray each in two sessions. At a median follow-up of 51 months (range: 6-116 months), seven (9.3%) patients developed distant metastasis, two (2.7%) patients had local plus distant metastasis, and two (2.7%) patients had local recurrence. The overall survival and disease-free survival rates at 3 years were 93.5% and 86.7%, respectively.

Conclusion: EC patients treated at our center have excellent local control rates with a combination of external beam radiotherapy and brachytherapy. The central histopathological review may result in changes impacting patient management and should be routinely done prior to initiation of treatment in EC.

目的/目标:子宫内膜癌(EC)是印度第三大最常见的妇科恶性肿瘤。最近的 PORTEC-3 分析强调了中央组织病理学审查的作用。我们旨在回顾性分析在我院接受治疗的子宫内膜癌患者的人口统计学和组织病理学特征,评估中央组织病理学审查对管理的影响,并分析该组患者的临床结果:从科室档案中检索了2013年至2022年间在本中心接受治疗的75例EC患者的数据。对患者的人口统计学细节、组织病理学结果、手术和组织病理学(HPE)细节、HPE复查结果、辅助治疗细节和临床结果进行了分析。所有在我院以外接受 HPE 治疗的患者在开始治疗前都在我院接受了复查。如果出现意见分歧,患者将在多学科肿瘤委员会进行讨论,以做出最终治疗决定。患者按照国际妇产科联盟2018年的标准进行分期:中位年龄为57岁(范围:37-74岁)。外院报告的 27 例 HPE 患者在本院进行了复查,观察到 26 例患者(96.3%)发生了变化。在组织学分级、组织学类型、子宫肌层浸润和淋巴结受累方面,分别有 5 例(18.5%)、3 例(11.1%)、7 例(25.9%)和 3 例(42.8%)患者的 HPE 复查结果发生了变化。HPE 复查导致 19/26 例患者的治疗方法发生改变。分期分布为 I:II:III:48 例(64%):9 (13.3%):18(24%)例患者的分期分布为 I:II:III。外照射放疗的中位剂量为50格雷(范围:45-50.4格雷,每分1.8-2格雷)。单纯近距离放射治疗患者的中位近距离放射治疗剂量为每次7格雷,共治疗三次;与EBRT联合治疗患者的中位近距离放射治疗剂量为每次6格雷,共治疗两次。在中位 51 个月(6-116 个月)的随访中,7 例(9.3%)患者出现远处转移,2 例(2.7%)患者出现局部加远处转移,2 例(2.7%)患者出现局部复发。3年的总生存率和无病生存率分别为93.5%和86.7%:结论:在本中心接受外照射放疗和近距离放疗联合治疗的EC患者的局部控制率非常高。中央组织病理学审查可能会导致影响患者管理的变化,因此应在开始治疗前对EC患者进行常规审查。
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引用次数: 0
Can physical parameters from radiation simulation scan with deep inspiratory breath hold predict magnitude of heart dose reduction? 深吸气屏气的辐射模拟扫描物理参数能否预测心脏剂量减少的幅度?
Pub Date : 2024-07-01 Epub Date: 2024-01-22 DOI: 10.4103/jcrt.jcrt_2668_22
Venkatesan Kannan, Sudesh Deshpande, Vivek Anand, Suresh Naidu, Kamalnayan Chauhan, Nazneen Chougle, Ritika Harjani Hinduja

Introduction: Deep inspiratory breath hold is one of the techniques for reducing the heart doses for left breast cancers. This study was conducted to confirm use of physical parameters from DIBH simulation CT scan like DIBH amplitude alongside several novel parameters to predict the heart dose reduction.

Materials and methods: Segmentation and planning of radiation to the left breast on the free breathing (FB) and DIBH simulation scan was performed for 50 left-sided breast cancer patients treated with DIBH technique. Physical parameters, namely DIBH amplitude, anterior sternal displacement, diaphragmatic excursion, ratio of lung volume (cc) in DIBH scan to lung volume in FB scan (cc), and delta heart volume in field (DHVIF), were extracted and were compared with magnitude of heart dose reduction (mean heart dose, V30Gy, and D5%).

Results: Forty-eight (96%) patients achieved reduction in the mean heart dose with DIBH technique, while all patients had reduction in V30Gy. The median reduction was 41%, 89.7%, and 63% in the mean dose, V30Gy, and D5%, respectively. While DIBH did not correlate with heart dose reduction, ratio of lung volumes and DHVIF showed a strong positive correlation with heart dose reduction (P < 0.05). Sternal displacement correlated weakly with heart dose reduction but strongly with DHVIF, demonstrating to be an indirect predictor.

Conclusions: Physical parameters like anterior sternal displacement, ratio of lung volumes of DIBH to FB, and possibly diaphragmatic movement can predict the dose reduction before the dose calculations by the physicist. These parameters can be used to construct a model to predict heart dose reduction.

简介深吸气屏气是减少左乳腺癌心脏剂量的技术之一。这项研究旨在确认深吸气憋气模拟 CT 扫描的物理参数(如深吸气憋气振幅)与几个新参数的结合使用,以预测心脏剂量的减少:对 50 名采用 DIBH 技术治疗的左侧乳腺癌患者进行了自由呼吸(FB)和 DIBH 模拟扫描,并对左侧乳房的放射线进行了分割和规划。提取了物理参数,即 DIBH 振幅、胸骨前位移、膈肌偏移、DIBH 扫描肺容积(cc)与 FB 扫描肺容积(cc)之比和心场内三角洲容积(DHVIF),并与心脏剂量减少幅度(平均心脏剂量、V30Gy 和 D5%)进行了比较:结果:48 名患者(96%)通过 DIBH 技术减少了平均心脏剂量,所有患者的 V30Gy 均有减少。平均剂量、V30Gy 和 D5% 的中位降低率分别为 41%、89.7% 和 63%。虽然 DIBH 与心脏剂量减少无关,但肺容积比和 DHVIF 与心脏剂量减少呈强正相关(P < 0.05)。胸骨移位与心脏剂量减少的相关性较弱,但与 DHVIF 的相关性较强,这表明胸骨移位是一个间接的预测指标:结论:物理参数,如胸骨前位移、DIBH与FB的肺容积之比,以及可能的膈肌运动,可以在物理学家计算剂量之前预测剂量减少。这些参数可用于构建预测心脏剂量减少的模型。
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引用次数: 0
Correlation of new two-dimensional geometrical parameters to lung and heart dose-volume parameters in breast cancer radiation therapy. 乳腺癌放射治疗中新的二维几何参数与肺和心脏剂量-体积参数的相关性。
Pub Date : 2024-07-01 Epub Date: 2024-09-19 DOI: 10.4103/jcrt.jcrt_2351_23
Maryam Bahador, Simin Soltaninejad, Mosayyeb Mobasheri

Objective: To develop new two-dimensional geometric parameters for pulmonary and cardiac dose estimation in left-sided breast cancer radiation therapy without dose-volume histogram (DVH).

Methods: On the CT image of 90 patients with left breast cancer, treatment planning was performed using two opposed tangent fields with/without supraclavicular. The field-in-field technique and 6MV photons were used. From DVH dosimetric parameters of mean dose, Vx (x (Gy) =5, 10, 15, 20, 30, 40, 50) were calculated, and from heart and lung outlines on the beam's eye view, new geometric parameters of percent of lung area in tangent and supraclavicular fields (%area of the lung in the tangent (ALT), %ALS) and percent of heart in tangent field (%area of the heart in the tangent (AHT)) were measured. Correlation, regression, and diagnostic performance by receiver operating characteristic curve (ROC) were investigated for statistical analysis.

Results: The Pearson coefficient between %ALT and Vx (x = 10, 15, 20, 30, 40) show strong correlation in patient treatment with only opposed tangents (>0.85) and weaker in treatment by opposed tangents with supraclavicular (0.56-0.88), the %ALS indicate weak correlation (<0.5) and %AHT show strong correlation (0.93-0.98). The regression analysis shows a positive relation between %ALT and mean dose (R2 = 0.8), V20Gy (R2 = 0.9) in the lung (tangent treatment), and between %AHT and mean dose (R2 = 0.9), V20Gy (R2 = 1.0) in the heart. The ROC analysis shows by %ALT <20.3 for treatment by just opposed fields, %ALT <22.1% for treatment tangents with supra, and %AHT <11.6%, practical lung and heart dose constraints are addressed.

Conclusion: The proposed geometric parameters could replace previous one-dimensional maximum and central distances for predicting doses to lung and heart.

Advances in knowledge: This study presents simple geometric parameters that could estimate pulmonary and cardiac dose in left breast cancer treatment from a 2D radiograph.

目的在没有剂量-体积直方图(DVH)的情况下,为左侧乳腺癌放射治疗中的肺和心脏剂量估算开发新的二维几何参数:在 90 名左侧乳腺癌患者的 CT 图像上,使用有/无锁骨上切线的两个相对切线场进行治疗规划。采用场中场技术和 6MV 光子。根据 DVH 计算出平均剂量的剂量学参数 Vx(x(Gy)=5、10、15、20、30、40、50),并根据束眼视图上的心肺轮廓,测量出切线场和锁骨上场中肺面积百分比(切线场中肺面积百分比(ALT)、ALS)和切线场中心脏面积百分比(切线场中心脏面积百分比(AHT))的新几何参数。对相关性、回归性和接收者操作特征曲线(ROC)的诊断性能进行了统计分析:结果:ALT%和 Vx(x = 10、15、20、30、40)之间的皮尔逊系数显示,在仅使用对置切线的患者治疗中相关性较强(>0.85),而在使用锁骨上对置切线的患者治疗中相关性较弱(0.56-0.88),ALS%显示相关性较弱:所提出的几何参数可取代以前的一维最大距离和中心距离,用于预测肺部和心脏的剂量:本研究提出了简单的几何参数,可通过二维X光片估算左侧乳腺癌治疗中的肺部和心脏剂量。
{"title":"Correlation of new two-dimensional geometrical parameters to lung and heart dose-volume parameters in breast cancer radiation therapy.","authors":"Maryam Bahador, Simin Soltaninejad, Mosayyeb Mobasheri","doi":"10.4103/jcrt.jcrt_2351_23","DOIUrl":"10.4103/jcrt.jcrt_2351_23","url":null,"abstract":"<p><strong>Objective: </strong>To develop new two-dimensional geometric parameters for pulmonary and cardiac dose estimation in left-sided breast cancer radiation therapy without dose-volume histogram (DVH).</p><p><strong>Methods: </strong>On the CT image of 90 patients with left breast cancer, treatment planning was performed using two opposed tangent fields with/without supraclavicular. The field-in-field technique and 6MV photons were used. From DVH dosimetric parameters of mean dose, Vx (x (Gy) =5, 10, 15, 20, 30, 40, 50) were calculated, and from heart and lung outlines on the beam's eye view, new geometric parameters of percent of lung area in tangent and supraclavicular fields (%area of the lung in the tangent (ALT), %ALS) and percent of heart in tangent field (%area of the heart in the tangent (AHT)) were measured. Correlation, regression, and diagnostic performance by receiver operating characteristic curve (ROC) were investigated for statistical analysis.</p><p><strong>Results: </strong>The Pearson coefficient between %ALT and Vx (x = 10, 15, 20, 30, 40) show strong correlation in patient treatment with only opposed tangents (>0.85) and weaker in treatment by opposed tangents with supraclavicular (0.56-0.88), the %ALS indicate weak correlation (<0.5) and %AHT show strong correlation (0.93-0.98). The regression analysis shows a positive relation between %ALT and mean dose (R2 = 0.8), V20Gy (R2 = 0.9) in the lung (tangent treatment), and between %AHT and mean dose (R2 = 0.9), V20Gy (R2 = 1.0) in the heart. The ROC analysis shows by %ALT <20.3 for treatment by just opposed fields, %ALT <22.1% for treatment tangents with supra, and %AHT <11.6%, practical lung and heart dose constraints are addressed.</p><p><strong>Conclusion: </strong>The proposed geometric parameters could replace previous one-dimensional maximum and central distances for predicting doses to lung and heart.</p><p><strong>Advances in knowledge: </strong>This study presents simple geometric parameters that could estimate pulmonary and cardiac dose in left breast cancer treatment from a 2D radiograph.</p>","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"20 5","pages":"1570-1577"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute gastroenteritis caused by Vibrio cholerae O1 Ogawa serotype in gastric cancer patient in Eastern India: Case report and review of literature. 印度东部胃癌患者由霍乱弧菌 O1 Ogawa 血清型引起的急性肠胃炎:病例报告和文献综述。
Pub Date : 2024-07-01 Epub Date: 2023-05-03 DOI: 10.4103/jcrt.jcrt_1539_22
Vijeta Bajpai, Gopal Nath, Anwita Mishra, Amit Kumar

Abstract: Acute gastroenteritis is the most common clinical manifestation of Vibrio cholerae infection. Cases of non-O1 V. cholerae infections in cancer patients have been previously reported in the literature. To our best knowledge, this is a unique case of V. cholerae classical biotype, serovar Ogawa infection in a young female patient with gastric malignancy.

摘要:急性肠胃炎是霍乱弧菌感染最常见的临床表现。以前曾有文献报道过癌症患者感染非 O1 型霍乱弧菌的病例。据我们所知,这是一例年轻女性胃部恶性肿瘤患者感染经典生物型小川血清霍乱弧菌的独特病例。
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引用次数: 0
Drug-induced acute febrile neutrophilic dermatosis (Sweet syndrome): A case report presented at Delhi State Cancer Institute. 药物诱发的急性发热性嗜中性皮肤病(斯威特综合征):德里国立癌症研究所的病例报告。
Pub Date : 2024-07-01 Epub Date: 2023-05-03 DOI: 10.4103/jcrt.jcrt_274_22
Afsana Shah, Santhosh Meedimale, Dinesh Kumar, Pooja Sharma, Pragya Shukla

Abstract: Sweet syndrome is a rare, etiologically unknown dermatosis that can be idiopathic or associated with certain clinical conditions. Among these conditions are infections, autoimmune diseases, inflammatory bowel diseases, vaccinations, the use of medications, and neoplasias. Hematological neoplasias, particularly acute myeloid leukemia, are the most commonly described; however, the condition may also be related to solid tumors, being those of the genitourinary tract the most associated with the syndrome. Drug-induced Sweet syndrome has also been reported; however, it is rarely seen. We report a case of 59 years old male patient with a diagnosis of carcinoma urinary bladder, who developed skin eruption after infusion of the first cycle of chemotherapy (gemcitabine and cisplatin) and resolved after treatment with steroids. The diagnosis of Sweet syndrome was confirmed only after skin biopsy, cultures and laboratory investigations. Malignancy as the cause of skin eruptions was eliminated by the fact that it occurred only after infusion of chemotherapy and the tumor was still there in the bladder, and skin eruptions did not occur after stopping steroids.

摘要:斯威特综合征是一种罕见的、病因不明的皮肤病,可能是特发性的,也可能与某些临床症状有关。这些病症包括感染、自身免疫性疾病、炎症性肠病、疫苗接种、使用药物和肿瘤。血液肿瘤,尤其是急性髓性白血病,是最常见的病因;不过,该病症也可能与实体瘤有关,其中泌尿生殖道肿瘤与该综合征的关系最为密切。药物诱发斯威特综合征也有报道,但很少见。我们报告了一例 59 岁的男性患者,诊断为膀胱癌,在输注第一周期化疗(吉西他滨和顺铂)后出现皮肤糜烂,经类固醇治疗后缓解。经过皮肤活检、培养和实验室检查,才确诊为斯威特综合征。恶性肿瘤是导致皮肤糜烂的原因,这一点已经被排除,因为皮肤糜烂只发生在输注化疗之后,而且膀胱中的肿瘤仍然存在,停用类固醇后也没有出现皮肤糜烂。
{"title":"Drug-induced acute febrile neutrophilic dermatosis (Sweet syndrome): A case report presented at Delhi State Cancer Institute.","authors":"Afsana Shah, Santhosh Meedimale, Dinesh Kumar, Pooja Sharma, Pragya Shukla","doi":"10.4103/jcrt.jcrt_274_22","DOIUrl":"10.4103/jcrt.jcrt_274_22","url":null,"abstract":"<p><strong>Abstract: </strong>Sweet syndrome is a rare, etiologically unknown dermatosis that can be idiopathic or associated with certain clinical conditions. Among these conditions are infections, autoimmune diseases, inflammatory bowel diseases, vaccinations, the use of medications, and neoplasias. Hematological neoplasias, particularly acute myeloid leukemia, are the most commonly described; however, the condition may also be related to solid tumors, being those of the genitourinary tract the most associated with the syndrome. Drug-induced Sweet syndrome has also been reported; however, it is rarely seen. We report a case of 59 years old male patient with a diagnosis of carcinoma urinary bladder, who developed skin eruption after infusion of the first cycle of chemotherapy (gemcitabine and cisplatin) and resolved after treatment with steroids. The diagnosis of Sweet syndrome was confirmed only after skin biopsy, cultures and laboratory investigations. Malignancy as the cause of skin eruptions was eliminated by the fact that it occurred only after infusion of chemotherapy and the tumor was still there in the bladder, and skin eruptions did not occur after stopping steroids.</p>","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"20 5","pages":"1605-1607"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pediatric hepatocellular carcinoma in a 14-year-old boy: A rare case report. 一名 14 岁男孩的小儿肝细胞癌:罕见病例报告。
Pub Date : 2024-07-01 Epub Date: 2024-09-19 DOI: 10.4103/jcrt.jcrt_1769_22
Jyoti Rajpoot, Manjula Jain, Mukta Pujani, Charu Agarwal, Ruchira Wadhwa, Monica Sarohi

Abstract: Hepatocellular carcinoma (HCC) is much rarer in children and adolescents in comparison to adults with an incidence of 0.7/1,000,000 per year. Hepatitis B virus, a known carcinogen increases the chances of HCC at a young age. Very few case reports of HCC developing in HBV-positive male children have been published.We present a case of a 14-year-old Hepatitis B-positive boy who presented with abdominal distension and jaundice. Contrast enhanced computerized tomography (CECT) whole abdomen suggested a diagnosis of multinodular HCC with no evidence of metastasis on FDG PET-CECT. Histopathology with immunohistochemistry confirmed the diagnosis of moderately differentiated HCC.Clinical presentation of HCC in children is similar to adults. Viral hepatitis, metabolic disorders, and male gender increase the risk of HCC. In our case, boy never had any prior history of jaundice, abdominal pain/distension, or any other illness suggestive of liver dysfunction. When the boy was found to be HBV positive, his mother was also screened and turned out to be Hepatitis B virus positive. Histopathology along with a panel of immunohistochemical markers clinched the final diagnosis.

摘要:与成年人相比,儿童和青少年的肝细胞癌(HCC)发病率要低得多,每年仅为 0.7/1,000,000 例。乙型肝炎病毒是一种已知的致癌物质,会增加幼年患上 HCC 的几率。我们报告了一例 14 岁乙肝阳性男孩的病例,他出现腹胀和黄疸。全腹部对比增强计算机断层扫描(CECT)提示诊断为多结节性肝癌,但 FDG PET-CECT 未显示转移迹象。免疫组化组织病理学确诊为中度分化型 HCC。病毒性肝炎、代谢紊乱和男性都会增加罹患 HCC 的风险。在我们的病例中,男孩之前从未有过黄疸、腹痛/腹胀或其他任何提示肝功能异常的病史。当发现男孩的 HBV 阳性时,他的母亲也接受了筛查,结果也是乙肝病毒阳性。组织病理学检查和免疫组化标记物检查确定了最终诊断。
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引用次数: 0
Polymorphous adenocarcinoma of the buccal space-Rare, reported case from our institute. 颊间隙多形性腺癌--本研究所报告的罕见病例。
Pub Date : 2024-07-01 Epub Date: 2023-05-03 DOI: 10.4103/jcrt.jcrt_466_22
Manjinder Singh Sidhu, Sumit Gupta, Shubhada Kane, Davinder Paul

Abstract: Polymorphous adenocarcinoma (PAC) of head and neck tumors is a rare salivary gland neoplasm of indolent course. We reported a 63-year-old female who presented as an asymptomatic mass in buccal space. The patient, after metastatic workup, underwent complete excision of the lesion with a negative margin. Postoperative histopathology and immunohistochemistry (IHC) were suggestive of PAC. Presently patient is on follow-up as per a multidisciplinary team decision. To conclude, PAC diagnosis is challenging due to morphological diversity, which necessities IHC. In addition, presently treatment of choice as per the literature review is complete excision.

摘要:头颈部肿瘤多形性腺癌(PAC)是一种罕见的唾液腺肿瘤,病程不长。我们报告了一名 63 岁女性患者的病例,她在口腔出现无症状肿块。经过转移检查后,患者接受了边缘阴性的病灶全切术。术后组织病理学和免疫组化(IHC)结果均提示为 PAC。根据多学科小组的决定,患者目前仍在接受随访。总之,由于形态的多样性,PAC 的诊断具有挑战性,因此需要进行免疫组化检查。此外,根据文献综述,目前的首选治疗方法是完全切除。
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引用次数: 0
Clinicopathological profile and survival analysis of esophageal carcinoma: A retrospective study in a tertiary care hospital in Northeast India. 食管癌的临床病理概况和存活率分析:印度东北部一家三级医院的回顾性研究。
Pub Date : 2024-07-01 Epub Date: 2023-12-15 DOI: 10.4103/jcrt.jcrt_7_23
Kishalay Baidya, Yumkhaibam Sobita Devi, Hari K Rai, Ningthoujam D Devi, Neeta Sinam, Gowtham L T Kilari

Background: Esophageal cancer (EC) is an extremely aggressive tumor with one of the highest geographic, ethnic, and gender variations. Various factors including tobacco consumption, unhealthy diet, and socioeconomic status have been implicated in the etiology of EC. Despite the advent of modern treatments, the prognosis of EC is dismal. This study has been undertaken to review the clinical and pathologic profiles, treatment approach, and survival pattern in patients with EC in a tertiary care hospital in northeast India.

Materials and methods: A retrospective descriptive study was done with 179 EC patients presented to our department between January 2013 and December 2020. Statistical analysis was done by using IBM Statistical Package for the Social Sciences version 21. P- value <0.05 was considered significant.

Results: The majority of the patients presented in the sixth decade of life from rural areas with male to female ratio of 3.7:1. Dysphagia was the most common presenting feature. High incidence of tobacco and alcohol use was found. Mid-esophagus is the most common site and squamous cell carcinoma is the most common type. Fifty-two (29.1%) and 71 (39.6%) patients presented in stages III and IV, respectively. Twenty-four (13.4%) patients presented with metastatic disease, the lung being the most common site. Patients were treated with surgery, chemotherapy, radiotherapy, or combination of any of these. Overall median survival for the EC patients was 6 months. Patients treated with concurrent chemoradiation had better survival.

Conclusion: EC is a serious malignancy with a dismal prognosis due to the advanced stage at presentation. Larger clinical trials using new therapeutic strategies are the need of the hour.

背景:食管癌(EC)是一种侵袭性极强的肿瘤,是地域、种族和性别差异最大的肿瘤之一。包括吸烟、不健康饮食和社会经济地位在内的各种因素都与食管癌的病因有关。尽管出现了现代治疗方法,但乳腺癌的预后仍然不容乐观。本研究旨在回顾性分析印度东北部一家三甲医院心肌梗死患者的临床和病理特征、治疗方法和生存模式:本研究对 2013 年 1 月至 2020 年 12 月期间在我科就诊的 179 名心肌梗死患者进行了回顾性描述性研究。使用 IBM 社会科学统计软件包第 21 版进行统计分析。P 值 结果:大多数患者来自农村地区,年龄在 60 岁左右,男女比例为 3.7:1。吞咽困难是最常见的发病特征。吸烟和饮酒的发病率很高。食道中段是最常见的部位,鳞状细胞癌是最常见的类型。分别有 52 名(29.1%)和 71 名(39.6%)患者处于 III 期和 IV 期。24例(13.4%)患者出现转移性疾病,肺部是最常见的部位。患者接受了手术、化疗、放疗或上述疗法的综合治疗。EC患者的总生存期中位数为6个月。同时接受化疗和放疗的患者生存率更高:结论:癌胚抗原是一种严重的恶性肿瘤,由于发病时已是晚期,预后很差。采用新的治疗策略进行更大规模的临床试验是当务之急。
{"title":"Clinicopathological profile and survival analysis of esophageal carcinoma: A retrospective study in a tertiary care hospital in Northeast India.","authors":"Kishalay Baidya, Yumkhaibam Sobita Devi, Hari K Rai, Ningthoujam D Devi, Neeta Sinam, Gowtham L T Kilari","doi":"10.4103/jcrt.jcrt_7_23","DOIUrl":"10.4103/jcrt.jcrt_7_23","url":null,"abstract":"<p><strong>Background: </strong>Esophageal cancer (EC) is an extremely aggressive tumor with one of the highest geographic, ethnic, and gender variations. Various factors including tobacco consumption, unhealthy diet, and socioeconomic status have been implicated in the etiology of EC. Despite the advent of modern treatments, the prognosis of EC is dismal. This study has been undertaken to review the clinical and pathologic profiles, treatment approach, and survival pattern in patients with EC in a tertiary care hospital in northeast India.</p><p><strong>Materials and methods: </strong>A retrospective descriptive study was done with 179 EC patients presented to our department between January 2013 and December 2020. Statistical analysis was done by using IBM Statistical Package for the Social Sciences version 21. P- value <0.05 was considered significant.</p><p><strong>Results: </strong>The majority of the patients presented in the sixth decade of life from rural areas with male to female ratio of 3.7:1. Dysphagia was the most common presenting feature. High incidence of tobacco and alcohol use was found. Mid-esophagus is the most common site and squamous cell carcinoma is the most common type. Fifty-two (29.1%) and 71 (39.6%) patients presented in stages III and IV, respectively. Twenty-four (13.4%) patients presented with metastatic disease, the lung being the most common site. Patients were treated with surgery, chemotherapy, radiotherapy, or combination of any of these. Overall median survival for the EC patients was 6 months. Patients treated with concurrent chemoradiation had better survival.</p><p><strong>Conclusion: </strong>EC is a serious malignancy with a dismal prognosis due to the advanced stage at presentation. Larger clinical trials using new therapeutic strategies are the need of the hour.</p>","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":" ","pages":"1406-1411"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138815369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The spectrum of late radiation sequelae in head and neck cancer. 头颈癌晚期放射后遗症的范围。
Pub Date : 2024-07-01 Epub Date: 2024-09-19 DOI: 10.4103/jcrt.jcrt_1453_23
Bhanu Vashistha, Preety Negi, Pamela A Kingsley

Introduction: Concurrent Chemoradiation is the standard of care in the treatment of unresectable locally advanced head and neck cancer. Some of the acute side effects seen after or alongside the head and neck radiotherapy include dermatitis, mucositis, xerostomia, dysphagia and swallowing dysfunction. Evolving data demonstrate that acute toxicities may persist long-term and develop into late effects. In addition, late effects may manifest months or years after completion of therapy, persisting for years or even lifelong, far longer than previously believed. When severe, late effects may profoundly affect function and quality of life. The present study was conducted to analyze the spectrum of late radiation toxicities in head and neck cancer patients treated with radical external beam radiation therapy and to determine its prevalence and severity.

Materials and methods: This prospective observational study was conducted in the Department of Radiotherapy, Christian Medical College and Hospital, Ludhiana. In all patients with a histopathological diagnosis of head and neck carcinoma who have received radical radiation therapy alone or definitive chemoradiation as part of cancer-directed therapy.

Results: Salivary gland toxicity was the most common toxicity encountered in head and neck cancer survivors resulting in dysphagia followed by dental caries, subcutaneous late effects and dysphagia. As expected, the spectrum of side effects correlated with the primary site, stage of disease and ECOG performance status.

Conclusion: Technological advancement in radiation planning and equipment has resulted in a reduction in the most feared side effects of radiation which has led to improvement in the quality of life of the survivors. As no technology can entirely protect normal tissues from irradiation, utmost care should be taken to minimize the radiation dose received by normal tissues by following preventive and supportive measures.

简介同期化疗是治疗无法切除的局部晚期头颈癌的标准疗法。头颈部放疗后或同时出现的一些急性副作用包括皮炎、粘膜炎、口腔干燥症、吞咽困难和吞咽功能障碍。不断发展的数据表明,急性毒性可能会长期存在,并发展成为晚期效应。此外,晚期效应可能在治疗结束后数月或数年才出现,持续数年甚至终生,远比以前认为的时间要长。严重时,晚期效应可能会严重影响患者的功能和生活质量。本研究旨在分析接受根治性外照射治疗的头颈部癌症患者的晚期放射毒性反应谱,并确定其发生率和严重程度:这项前瞻性观察研究在卢迪亚纳基督教医学院和医院放疗科进行。所有组织病理学诊断为头颈部癌的患者都接受了单纯根治性放疗或作为癌症导向疗法一部分的确定性化疗:结果:唾液腺毒性是头颈癌幸存者最常见的毒性反应,会导致吞咽困难,其次是龋齿、皮下晚期反应和吞咽困难。正如预期的那样,副作用的范围与原发部位、疾病分期和 ECOG 表现状态相关:结论:放射计划和设备技术的进步减少了人们最担心的放射副作用,从而提高了幸存者的生活质量。由于任何技术都无法完全保护正常组织免受照射,因此应采取预防和支持措施,最大限度地减少正常组织接受的辐射剂量。
{"title":"The spectrum of late radiation sequelae in head and neck cancer.","authors":"Bhanu Vashistha, Preety Negi, Pamela A Kingsley","doi":"10.4103/jcrt.jcrt_1453_23","DOIUrl":"10.4103/jcrt.jcrt_1453_23","url":null,"abstract":"<p><strong>Introduction: </strong>Concurrent Chemoradiation is the standard of care in the treatment of unresectable locally advanced head and neck cancer. Some of the acute side effects seen after or alongside the head and neck radiotherapy include dermatitis, mucositis, xerostomia, dysphagia and swallowing dysfunction. Evolving data demonstrate that acute toxicities may persist long-term and develop into late effects. In addition, late effects may manifest months or years after completion of therapy, persisting for years or even lifelong, far longer than previously believed. When severe, late effects may profoundly affect function and quality of life. The present study was conducted to analyze the spectrum of late radiation toxicities in head and neck cancer patients treated with radical external beam radiation therapy and to determine its prevalence and severity.</p><p><strong>Materials and methods: </strong>This prospective observational study was conducted in the Department of Radiotherapy, Christian Medical College and Hospital, Ludhiana. In all patients with a histopathological diagnosis of head and neck carcinoma who have received radical radiation therapy alone or definitive chemoradiation as part of cancer-directed therapy.</p><p><strong>Results: </strong>Salivary gland toxicity was the most common toxicity encountered in head and neck cancer survivors resulting in dysphagia followed by dental caries, subcutaneous late effects and dysphagia. As expected, the spectrum of side effects correlated with the primary site, stage of disease and ECOG performance status.</p><p><strong>Conclusion: </strong>Technological advancement in radiation planning and equipment has resulted in a reduction in the most feared side effects of radiation which has led to improvement in the quality of life of the survivors. As no technology can entirely protect normal tissues from irradiation, utmost care should be taken to minimize the radiation dose received by normal tissues by following preventive and supportive measures.</p>","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"20 5","pages":"1578-1583"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Journal of cancer research and therapeutics
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