Pub Date : 2025-12-04DOI: 10.1016/j.jcct.2025.11.082
Adrian Bednarek, Natan Adamów, Krzysztof Badura, Marta Mazur, Julia Białecka, Magdalena Dobrolińska, Paweł Siuciak, Krzysztof Milewski, Jarosław Drożdż, Miłosz Jaguszewski, Wojciech Wojakowski, Zenon Huczek, Janusz Kochman, Mariusz Tomaniak
{"title":"Accuracy of on-site CT-μFR analyses for evaluation of intermediate coronary stenoses in patients undergoing TAVI.","authors":"Adrian Bednarek, Natan Adamów, Krzysztof Badura, Marta Mazur, Julia Białecka, Magdalena Dobrolińska, Paweł Siuciak, Krzysztof Milewski, Jarosław Drożdż, Miłosz Jaguszewski, Wojciech Wojakowski, Zenon Huczek, Janusz Kochman, Mariusz Tomaniak","doi":"10.1016/j.jcct.2025.11.082","DOIUrl":"https://doi.org/10.1016/j.jcct.2025.11.082","url":null,"abstract":"","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145688904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-26DOI: 10.1016/j.jcct.2025.11.003
Nadia Solomon, Matthew Hoerner, Billy Vermillion, Sun-Joo Jang, Harold Sanchez, Babina Gosangi, Lawrence Staib, Stephanie L Thorn, Chi Liu, Albert J Sinusas
{"title":"Corrigendum to \"Applying dual energy computed tomography to postmortem coronary computed tomographic angiography\" [J Cardiovasc Comput Tomogr (in press)].","authors":"Nadia Solomon, Matthew Hoerner, Billy Vermillion, Sun-Joo Jang, Harold Sanchez, Babina Gosangi, Lawrence Staib, Stephanie L Thorn, Chi Liu, Albert J Sinusas","doi":"10.1016/j.jcct.2025.11.003","DOIUrl":"10.1016/j.jcct.2025.11.003","url":null,"abstract":"","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145644145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-25DOI: 10.1016/j.jcct.2025.11.079
Vinoda Sharma, Ahmed Hassan, Saba Kouser, Leong Lee, Sandeep Basavarajaiah, Sohail Khan, Abdul Mozid, Francis Joshi, Aadil Shaukat, Vivek Kodoth, Andrew Ladwiniec, Jawad Khan
Background: Calcification in a chronic total occlusion (CTO) is better visualised on Computed Tomography Coronary Angiography (CTCA) than invasive angiography.
Objectives: The authors sought to assess the characteristics of calcification of a CTO on CTCA and correlate with CTO percutaneous coronary intervention (PCI) outcome.
Methods: Retrospective analysis of the PCI database was performed (April 2017-April 2024) (clinical trials registration: NCT06414551). Patients who underwent both CTO PCI and CTCA were grouped into successful CTO PCI and any failed attempt of CTO PCI and compared for characteristics of calcification on CTCA: site of calcification, density of calcification in Hounsfield Units (HU) and quantity of calcification in % of cross section of the vessel.
Results: Out of 499 CTO PCIs performed, 82 patients had undergone CTCA. 51/82 (62.2 %) patients had analysable CTCAs. Mean age was 68.5 (±10.9) years and 19.6 % were female. Patients in the failed group were more likely to have calcification in the proximal cap (failed 65.4 % vs. success 24 %, p = 0.003), more dense calcification in the proximal cap (failed: 611.8 (±517) HU vs. success: 177.6 (±356) HU; p = 0.001) and proximal cap calcification quantity ≥50 % (failed: 75 % vs. success 16.7 %, p = 0.03). Proximal cap calcification ≥50 % was an independent predictor of CTO PCI failure (OR, 3.21, 95 % CI 1.29 to 7.98, p = 0.012).
Conclusions: Proximal cap calcification density and quantity on CTCA was associated with CTO PCI failure. Assessment of the proximal cap calcification may help with procedure planning in CTO PCI. Larger, prospective multicentre studies are required to corroborate these findings.
{"title":"Assessment of calcium characteristics in chronic total occlusion using computed tomography coronary angiogram and implications for percutaneous coronary intervention.","authors":"Vinoda Sharma, Ahmed Hassan, Saba Kouser, Leong Lee, Sandeep Basavarajaiah, Sohail Khan, Abdul Mozid, Francis Joshi, Aadil Shaukat, Vivek Kodoth, Andrew Ladwiniec, Jawad Khan","doi":"10.1016/j.jcct.2025.11.079","DOIUrl":"https://doi.org/10.1016/j.jcct.2025.11.079","url":null,"abstract":"<p><strong>Background: </strong>Calcification in a chronic total occlusion (CTO) is better visualised on Computed Tomography Coronary Angiography (CTCA) than invasive angiography.</p><p><strong>Objectives: </strong>The authors sought to assess the characteristics of calcification of a CTO on CTCA and correlate with CTO percutaneous coronary intervention (PCI) outcome.</p><p><strong>Methods: </strong>Retrospective analysis of the PCI database was performed (April 2017-April 2024) (clinical trials registration: NCT06414551). Patients who underwent both CTO PCI and CTCA were grouped into successful CTO PCI and any failed attempt of CTO PCI and compared for characteristics of calcification on CTCA: site of calcification, density of calcification in Hounsfield Units (HU) and quantity of calcification in % of cross section of the vessel.</p><p><strong>Results: </strong>Out of 499 CTO PCIs performed, 82 patients had undergone CTCA. 51/82 (62.2 %) patients had analysable CTCAs. Mean age was 68.5 (±10.9) years and 19.6 % were female. Patients in the failed group were more likely to have calcification in the proximal cap (failed 65.4 % vs. success 24 %, p = 0.003), more dense calcification in the proximal cap (failed: 611.8 (±517) HU vs. success: 177.6 (±356) HU; p = 0.001) and proximal cap calcification quantity ≥50 % (failed: 75 % vs. success 16.7 %, p = 0.03). Proximal cap calcification ≥50 % was an independent predictor of CTO PCI failure (OR, 3.21, 95 % CI 1.29 to 7.98, p = 0.012).</p><p><strong>Conclusions: </strong>Proximal cap calcification density and quantity on CTCA was associated with CTO PCI failure. Assessment of the proximal cap calcification may help with procedure planning in CTO PCI. Larger, prospective multicentre studies are required to corroborate these findings.</p>","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145644105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-08DOI: 10.1016/j.jcct.2025.10.019
Gianluca Di Pietro, Riccardo Improta, Alessandro Napoli, Achille Gaspardone, Fabrizio Tomai, Gennaro Sardella, Marco Francone, Nicola Galea, Massimo Mancone
{"title":"A \"CCTA guided-ICA\" approach in patients with a previous history of CABG: An exploratory metanalysis.","authors":"Gianluca Di Pietro, Riccardo Improta, Alessandro Napoli, Achille Gaspardone, Fabrizio Tomai, Gennaro Sardella, Marco Francone, Nicola Galea, Massimo Mancone","doi":"10.1016/j.jcct.2025.10.019","DOIUrl":"https://doi.org/10.1016/j.jcct.2025.10.019","url":null,"abstract":"","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145484526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-30DOI: 10.1016/j.jcct.2025.10.006
John D Wagner, Marissa E Adamson, Hunter C Wilson, Sassan Hashemi, Joshua M Rosenblum, Ritu Sachdeva
{"title":"Preoperative imaging accuracy and resource utilization in sinus venosus atrial septal defects.","authors":"John D Wagner, Marissa E Adamson, Hunter C Wilson, Sassan Hashemi, Joshua M Rosenblum, Ritu Sachdeva","doi":"10.1016/j.jcct.2025.10.006","DOIUrl":"https://doi.org/10.1016/j.jcct.2025.10.006","url":null,"abstract":"","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145423742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-23DOI: 10.1016/j.jcct.2025.10.012
Kyung An Kim, Hae-Ok Jung, Mi-Jeong Kim, So-Young Lee, Dong-Hyeon Lee, Donghee Han, Hyuk-Jae Chang, Su-Yeon Choi, Jidong Sung, Eun Ju Chun
Background: Higher serum phosphate levels are associated with cardiovascular diseases, including coronary artery calcification (CAC). However, there exists limited evidence supporting a causal relationship between phosphate levels and CAC progression.
Methods: Using the KOrea Initiatives on Coronary Artery Calcification (KOICA) registry, we assessed CAC using the CAC score assessed by cardiac computed tomography (CT) in participants with normal serum phosphate (2.5-4.5 mg/dL) and calcium levels and without renal dysfunction (estimated glomerular filtration rate ≥60 mL/min/1.73 m2). The effect of serum phosphate and calcium levels on the prevalence and severity of CAC at baseline and the longitudinal progression of CAC were analyzed using multivariable regression models.
Results: A total of 12,251 individuals and 31,251 CT scans were selected for analysis, with a median follow-up duration of 3.5 (interquartile range 2.1-5.1) years. In the baseline cross-sectional analysis, serum phosphate levels were associated with higher CAC prevalence (OR per 1 mg/dL increase, 1.09, 95 % CI 1.06-1.11, p < 0.001) and CAC severity (β-coefficient per 1 mg/dL increase, 0.35, 95 % CI 0.25, 0.45, p < 0.001). In longitudinal analysis, serum phosphate levels also showed a significant association with higher probability of CAC progression (HR per 1 mg/dL increase, 1.19, 95 % CI, 1.06, 1.32; p < 0.001) and faster CAC score progression (β coefficient per 1 mg/dL, 2.54 × 10-2; 95 % CI, 1.43 × 10-2-3.67 × 10-2; p < 0.001).
Conclusion: Higher serum phosphate levels, even within the normal range, are associated with faster CAC progression. Further studies are needed to demonstrate the possibility of slowing CAC development through the regulation of calcium-phosphate metabolism.
背景：较高的血清磷酸盐水平与心血管疾病有关，包括冠状动脉钙化（CAC）。然而，支持磷酸盐水平与CAC进展之间因果关系的证据有限。方法：使用韩国冠状动脉钙化计划（KOICA）注册表，我们对血清磷酸盐（2.5-4.5 mg/dL）和钙水平正常且无肾功能障碍（估计肾小球滤过率≥60 mL/min/1.73 m2）的参与者使用心脏计算机断层扫描（CT）评估的CAC评分来评估CAC。采用多变量回归模型分析血清磷酸盐和钙水平对基线时CAC患病率和严重程度以及CAC纵向进展的影响。结果：共有12251名患者和31251个CT扫描被选择用于分析，中位随访时间为3.5年（四分位数间距为2.1-5.1）。在基线横断面分析中，血清磷酸盐水平与较高的CAC患病率（每增加1 mg/dL的OR， 1.09, 95% CI 1.06-1.11, p < 0.001）和CAC严重程度（每增加1 mg/dL的β系数，0.35,95% CI 0.25, 0.45, p < 0.001）相关。在纵向分析中，血清磷酸盐水平也显示与更高的CAC进展概率（每1 mg/dL增加的HR， 1.19, 95% CI, 1.06, 1.32, p < 0.001）和更快的CAC评分进展（每1 mg/dL β系数，2.54 × 10-2, 95% CI, 1.43 × 10-2-3.67 × 10-2, p < 0.001）显著相关。结论：较高的血清磷酸盐水平，即使在正常范围内，也与CAC的快速进展有关。需要进一步的研究来证明通过调节磷酸钙代谢来减缓CAC发展的可能性。
{"title":"The role of serum phosphate and calcium levels in coronary artery calcification progression: A multicenter, longitudinal cohort study.","authors":"Kyung An Kim, Hae-Ok Jung, Mi-Jeong Kim, So-Young Lee, Dong-Hyeon Lee, Donghee Han, Hyuk-Jae Chang, Su-Yeon Choi, Jidong Sung, Eun Ju Chun","doi":"10.1016/j.jcct.2025.10.012","DOIUrl":"https://doi.org/10.1016/j.jcct.2025.10.012","url":null,"abstract":"<p><strong>Background: </strong>Higher serum phosphate levels are associated with cardiovascular diseases, including coronary artery calcification (CAC). However, there exists limited evidence supporting a causal relationship between phosphate levels and CAC progression.</p><p><strong>Methods: </strong>Using the KOrea Initiatives on Coronary Artery Calcification (KOICA) registry, we assessed CAC using the CAC score assessed by cardiac computed tomography (CT) in participants with normal serum phosphate (2.5-4.5 mg/dL) and calcium levels and without renal dysfunction (estimated glomerular filtration rate ≥60 mL/min/1.73 m<sup>2</sup>). The effect of serum phosphate and calcium levels on the prevalence and severity of CAC at baseline and the longitudinal progression of CAC were analyzed using multivariable regression models.</p><p><strong>Results: </strong>A total of 12,251 individuals and 31,251 CT scans were selected for analysis, with a median follow-up duration of 3.5 (interquartile range 2.1-5.1) years. In the baseline cross-sectional analysis, serum phosphate levels were associated with higher CAC prevalence (OR per 1 mg/dL increase, 1.09, 95 % CI 1.06-1.11, p < 0.001) and CAC severity (β-coefficient per 1 mg/dL increase, 0.35, 95 % CI 0.25, 0.45, p < 0.001). In longitudinal analysis, serum phosphate levels also showed a significant association with higher probability of CAC progression (HR per 1 mg/dL increase, 1.19, 95 % CI, 1.06, 1.32; p < 0.001) and faster CAC score progression (β coefficient per 1 mg/dL, 2.54 × 10<sup>-2</sup>; 95 % CI, 1.43 × 10<sup>-2</sup>-3.67 × 10<sup>-2</sup>; p < 0.001).</p><p><strong>Conclusion: </strong>Higher serum phosphate levels, even within the normal range, are associated with faster CAC progression. Further studies are needed to demonstrate the possibility of slowing CAC development through the regulation of calcium-phosphate metabolism.</p>","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145369241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-14DOI: 10.1016/j.jcct.2025.10.002
Akash Sivananthan, Thamil Kumaran S M, Ibrahim Halil Tanboga, Amear Mohammed, Anantharaman Ramasamy, Andreas S Kalogeropoulos, Mick Ozkor, Gonul Zeren, Nathan A L Yap, Xingwei He, Patrick Serruys, James C Moon, Anthony Mathur, Alexander Broersen, Pieter Kitslaar, Xiaotong Zhang, Johan H C Reiber, Jouke Dijkstra, Francesca Pugliese, Andreas Baumbach, Ryo Torii, Christos V Bourantas
{"title":"Deep-learning analysis of computed tomography coronary angiography data enables more accurate computation of the shear stress distribution than conventional analysis by experts: A head-to-head comparison with near-infrared spectroscopy-intravascular ultrasound-based modelling.","authors":"Akash Sivananthan, Thamil Kumaran S M, Ibrahim Halil Tanboga, Amear Mohammed, Anantharaman Ramasamy, Andreas S Kalogeropoulos, Mick Ozkor, Gonul Zeren, Nathan A L Yap, Xingwei He, Patrick Serruys, James C Moon, Anthony Mathur, Alexander Broersen, Pieter Kitslaar, Xiaotong Zhang, Johan H C Reiber, Jouke Dijkstra, Francesca Pugliese, Andreas Baumbach, Ryo Torii, Christos V Bourantas","doi":"10.1016/j.jcct.2025.10.002","DOIUrl":"https://doi.org/10.1016/j.jcct.2025.10.002","url":null,"abstract":"","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145305181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Response to Letter - referencing JCCT-D-25-426 ''Integrating radiomics into coronary computed tomography angiography: Enhancing prognostic value after percutaneous coronary intervention'' by Macit Kalçık et al.","authors":"Yunosuke Matsuura, Soichi Komaki, Yoshikazu Uchiyama, Koichi Kaikita","doi":"10.1016/j.jcct.2025.09.015","DOIUrl":"https://doi.org/10.1016/j.jcct.2025.09.015","url":null,"abstract":"","PeriodicalId":94071,"journal":{"name":"Journal of cardiovascular computed tomography","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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