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Journal of the College of Physicians and Surgeons--Pakistan : JCPSP最新文献

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Tofersen for Amyotrophic Lateral Sclerosis: A Step Forward or Another False Hope?
Pub Date : 2025-02-01 DOI: 10.29271/jcpsp.2025.02.259
Araj Naveed, Waqas Ahmed Usmani, Mansi Prakashchandra Vandara, Vikash Kumar Karmani

Null.

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引用次数: 0
Association of HLA-B51/5 in Patients of Behcet's Disease Referred to a Tertiary Care Hospital in Pakistan.
Pub Date : 2025-02-01 DOI: 10.29271/jcpsp.2025.02.247
Mustajab Alam, Usama Bin Khalid, Dawood Ahmad, Muhammad Omair Riaz, Muhammad Hussain, Muhammad Zain Arshad

Objective: To determine the association of HLA-B51/5 in patients of Behcet's disease (BD) in local symptomatic patients.

Study design:  A cross-sectional study. Place and Duration of the Study: Department of Immunology, Armed Forces Institute of Pathology, Rawalpindi, Pakistan, from August 2020 to July 2023.

Methodology: Blood samples of 100 study participants, including 50 symptomatic patients of BD and 50 disease-free individuals (healthy controls), were taken. DNA was extracted and amplified using sequence-specific primers. Electrophoresis was conducted on 2% agarose gel to separate the DNA. The presence of HLA-B51/5 alleles was determined by analysing the unique band patterns visible on the gel under the ultraviolet light. Descriptive statistics were shown as mean ± SD. Chi-square test was employed to find any significant association between HLA-B51/5 and the disease group and its severity sub-groups. A p-value of less than 0.05 was deemed significant.

Results: The majority of participants, 73 (73%), were females and 27 (27%) were males, with a mean age of 26.84 ± 5.31 years. HLA-B51/5 was positive in 33 of the BD patients (66.0%, <0.001) and 4 of the healthy controls (8.0%). There was no significant difference in HLA-B51 among mild, moderate, and severe BD sub-groups.

Conclusion: HLA-B51/5 is strongly associated with BD in local population and serves as a useful tool for diagnosis of BD. However, it is not associated with the disease severity.

Key words: Agarose gel, Behcet's disease, Electrophoresis, HLA-B51/5 allele, ICBD criteria.

{"title":"Association of HLA-B51/5 in Patients of Behcet's Disease Referred to a Tertiary Care Hospital in Pakistan.","authors":"Mustajab Alam, Usama Bin Khalid, Dawood Ahmad, Muhammad Omair Riaz, Muhammad Hussain, Muhammad Zain Arshad","doi":"10.29271/jcpsp.2025.02.247","DOIUrl":"https://doi.org/10.29271/jcpsp.2025.02.247","url":null,"abstract":"<p><strong>Objective: </strong>To determine the association of HLA-B51/5 in patients of Behcet's disease (BD) in local symptomatic patients.</p><p><strong>Study design: </strong> A cross-sectional study. Place and Duration of the Study: Department of Immunology, Armed Forces Institute of Pathology, Rawalpindi, Pakistan, from August 2020 to July 2023.</p><p><strong>Methodology: </strong>Blood samples of 100 study participants, including 50 symptomatic patients of BD and 50 disease-free individuals (healthy controls), were taken. DNA was extracted and amplified using sequence-specific primers. Electrophoresis was conducted on 2% agarose gel to separate the DNA. The presence of HLA-B51/5 alleles was determined by analysing the unique band patterns visible on the gel under the ultraviolet light. Descriptive statistics were shown as mean ± SD. Chi-square test was employed to find any significant association between HLA-B51/5 and the disease group and its severity sub-groups. A p-value of less than 0.05 was deemed significant.</p><p><strong>Results: </strong>The majority of participants, 73 (73%), were females and 27 (27%) were males, with a mean age of 26.84 ± 5.31 years. HLA-B51/5 was positive in 33 of the BD patients (66.0%, <0.001) and 4 of the healthy controls (8.0%). There was no significant difference in HLA-B51 among mild, moderate, and severe BD sub-groups.</p><p><strong>Conclusion: </strong>HLA-B51/5 is strongly associated with BD in local population and serves as a useful tool for diagnosis of BD. However, it is not associated with the disease severity.</p><p><strong>Key words: </strong>Agarose gel, Behcet's disease, Electrophoresis, HLA-B51/5 allele, ICBD criteria.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 2","pages":"247-250"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143401106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Efficacy of Ganglioside Combined with Methylprednisolone in the Treatment of Spinal Cord Injury and Its Effect on Inflammatory Response and Oxidative Stress Factors.
Pub Date : 2025-02-01 DOI: 10.29271/jcpsp.2025.02.238
Dongliang Ren, Hui Li, Xiangdong Liu, Meihua Wang

Objective: To determine the clinical efficacy of monosialotetrahexosylganglioside (GM1) combined with methylprednisolone in the treatment of spinal cord injury (SCI).

Study design: An observational study. Place and Duration of the Study: Department of Orthopaedics, Baoding No.1 Central Hospital, Baoding, Hebei, China, from January 2018 to June 2021.

Methodology: A total of 80 patients with SCI were divided into control and observation groups according to treatment methods, the control group receiving methylprednisolone treatment and the observation group receiving methylprednisolone combined with GM1. The effective rate of treatment, time of normal muscle strength recovery, walk on the ground, and hospital stay were compared. The changes in the American Spinal Injury Association (ASIA) score, activity of daily living (ADL), serum inflammatory factors, oxidative stress factor levels, and adverse reactions were recorded.

Results: The effective rate of clinical efficacy of the observation group was 92.50%, surpassing the control group's which was 75.00% (χ2 = 4.501, p = 0.034). The observation group had a shorter recovery time for muscle strength, walking time, and hospital stay compared to the control group (p <0.05). After treatment, the ADL scores of both groups were higher than before treatment, and the degree of increase in the observation group was higher than the control group (p <0.05). The levels of serum tumour necrosis factor-α (TNF-α) and interleukin-8 (IL-8) for all patients were significantly reduced, with the observation group showing a more significant decrease (p <0.05). There was a notable increase in glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) levels in both groups, while the levels of malondialdehyde (MDA) decreased significantly. GSH-Px, SOD, and MDA levels were significantly greater in the observation group (p <0.05).

Conclusion: The combination of methylprednisolone and MG1 treatment of SCI can significantly reduce the inflammatory response and improve clinical efficacy.

Key words: Spinal cord injury, Ganglioside, Methylprednisolone, Inflammatory indicators, Oxidative stress.

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引用次数: 0
Clinical Utility of Serum Dehydroepiandrosterone Sulfate (DHEA-S) and Serum Anti-Mullerian Hormone (AMH) Levels in Infertile Females.
Pub Date : 2025-02-01 DOI: 10.29271/jcpsp.2025.02.157
Rimsha Sehar, Muhammad Younas, Zujaja Hina Haroon, Muhammad Anwar, Muhammad Usman Munir

Objective: To determine the correlation of serum dehydroepiandrosterone sulphate and anti-mullerian hormone levels with infertility in females.

Study design: Cross-sectional study. Place and Duration of the Study: Department of Chemical Pathology, the Armed Forces Institute of Pathology, Rawalpindi, Pakistan, from July 2022 to August 2023.

Methodology: About 110 infertile females with infertility were enrolled in this study. Serum thyroid-stimulating hormone, luteinising hormone, testosterone, follicle-stimulating hormone (FSH), estradiol, serum Anti-Mullerian Hormone (AMH), and Dehydroepiandrosterone Sulphate (DHEA-S) were measured at 3rd menstruation day. Females with primary ovarian insufficiency, using androgen supplementation, and on hormonal therapy were excluded.

Results: Among the participants, 63.6% had primary infertility and 36.4% had secondary infertility. Both primary and secondary infertility had a positive correlation with serum AMH and DHEA-S levels (r = 0.685; p <0.001) and (r = 0.807; p <0.001), respectively. After ultrasound, 54 (49.1%) females were normal, 12 (10.9%) had PCOS, 12 (10.9%) had fibroids, 8 (7.3%) had fallopian tube defects, 10 (9.1%) had endometriosis, and 14 (12.7%) had low antral follicular count. The correlation between serum AMH and DHEA-S with different subgroups is as follows: Normal females (r = 0.731; p <0.001), PCOs (r = -0.232; p = 0.468), fibroids (r = 0.941, p <0.001), fallopian tube defects (r =-0.800; p = 0.017), endometriosis (r = -0.684, p = 0.013), and low antral follicular count (r = 0.643, p = 0.0130).

Conclusion: This study demonstrated a positive correlation between serum AMH and DHEA-S levels in infertile females.

Key words: Infertile women, Ovarian reserve, Anti-Mullerian Hormone, Dehydroepiandrosterone sulphate.

{"title":"Clinical Utility of Serum Dehydroepiandrosterone Sulfate (DHEA-S) and Serum Anti-Mullerian Hormone (AMH) Levels in Infertile Females.","authors":"Rimsha Sehar, Muhammad Younas, Zujaja Hina Haroon, Muhammad Anwar, Muhammad Usman Munir","doi":"10.29271/jcpsp.2025.02.157","DOIUrl":"https://doi.org/10.29271/jcpsp.2025.02.157","url":null,"abstract":"<p><strong>Objective: </strong>To determine the correlation of serum dehydroepiandrosterone sulphate and anti-mullerian hormone levels with infertility in females.</p><p><strong>Study design: </strong>Cross-sectional study. Place and Duration of the Study: Department of Chemical Pathology, the Armed Forces Institute of Pathology, Rawalpindi, Pakistan, from July 2022 to August 2023.</p><p><strong>Methodology: </strong>About 110 infertile females with infertility were enrolled in this study. Serum thyroid-stimulating hormone, luteinising hormone, testosterone, follicle-stimulating hormone (FSH), estradiol, serum Anti-Mullerian Hormone (AMH), and Dehydroepiandrosterone Sulphate (DHEA-S) were measured at 3rd menstruation day. Females with primary ovarian insufficiency, using androgen supplementation, and on hormonal therapy were excluded.</p><p><strong>Results: </strong>Among the participants, 63.6% had primary infertility and 36.4% had secondary infertility. Both primary and secondary infertility had a positive correlation with serum AMH and DHEA-S levels (r = 0.685; p <0.001) and (r = 0.807; p <0.001), respectively. After ultrasound, 54 (49.1%) females were normal, 12 (10.9%) had PCOS, 12 (10.9%) had fibroids, 8 (7.3%) had fallopian tube defects, 10 (9.1%) had endometriosis, and 14 (12.7%) had low antral follicular count. The correlation between serum AMH and DHEA-S with different subgroups is as follows: Normal females (r = 0.731; p <0.001), PCOs (r = -0.232; p = 0.468), fibroids (r = 0.941, p <0.001), fallopian tube defects (r =-0.800; p = 0.017), endometriosis (r = -0.684, p = 0.013), and low antral follicular count (r = 0.643, p = 0.0130).</p><p><strong>Conclusion: </strong>This study demonstrated a positive correlation between serum AMH and DHEA-S levels in infertile females.</p><p><strong>Key words: </strong>Infertile women, Ovarian reserve, Anti-Mullerian Hormone, Dehydroepiandrosterone sulphate.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 2","pages":"157-161"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143401111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring Metabolomic Drivers of Colorectal and Gastric Cancer: A Mendelian Randomisation Study.
Pub Date : 2025-02-01 DOI: 10.29271/jcpsp.2025.02.203
Yiming Wang, Mi Jian, Jinchen Hu

Objective: To evaluate the causal relationship between 1,400 metabolites and colorectal and gastric cancer.

Study design: Mendelian randomisation study. Place and Duration of the Study: The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China, from July to August 2024.

Methodology: Metabolite genome-wide association study (GWAS) data and genetic data from the Canadian Longitudinal Study on Aging (CLSA) as well as the expensive FinnGen project, respectively, were sourced. Suitable instrumental variables were chosen based on their association with metabolites at a genome-wide significance level, thus ensuring a high degree of reliability in the causal inferences drawn. Inverse variance weighting (IVW) was used for initial analysis. Sensitivity analyses were conducted using MR Egger regression and weighted median methods to validate findings and assess potential pleiotropy or bias.

Results: Metabolites were included in the study of 8,299 individuals. Gastric cancer included 1,307 cases and 287,137 controls; while colorectal cancer included 6,509 cases and 287,137 controls. The research identified sixty-nine metabolites associated with varying degrees of risk enhancement or mitigation. For gastric cancer, a more focused discovery highlighted two metabolites with significant causal links-associated with increased risk as well as a protective effect. Sensitivity analyses confirmed the validity of these findings.

Conclusion: By elucidating specific metabolites that exert direct causal effects on colorectal and gastric cancer risk, the study marked a significant advancement in the understanding of the metabolic pathways involved in cancer development.

Key words: Mendelian randomisation, Colorectal cancer, Gastric cancer, Metabolites, Genetic variants, Genome-wide association studies, Causal inference.

{"title":"Exploring Metabolomic Drivers of Colorectal and Gastric Cancer: A Mendelian Randomisation Study.","authors":"Yiming Wang, Mi Jian, Jinchen Hu","doi":"10.29271/jcpsp.2025.02.203","DOIUrl":"https://doi.org/10.29271/jcpsp.2025.02.203","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the causal relationship between 1,400 metabolites and colorectal and gastric cancer.</p><p><strong>Study design: </strong>Mendelian randomisation study. Place and Duration of the Study: The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China, from July to August 2024.</p><p><strong>Methodology: </strong>Metabolite genome-wide association study (GWAS) data and genetic data from the Canadian Longitudinal Study on Aging (CLSA) as well as the expensive FinnGen project, respectively, were sourced. Suitable instrumental variables were chosen based on their association with metabolites at a genome-wide significance level, thus ensuring a high degree of reliability in the causal inferences drawn. Inverse variance weighting (IVW) was used for initial analysis. Sensitivity analyses were conducted using MR Egger regression and weighted median methods to validate findings and assess potential pleiotropy or bias.</p><p><strong>Results: </strong>Metabolites were included in the study of 8,299 individuals. Gastric cancer included 1,307 cases and 287,137 controls; while colorectal cancer included 6,509 cases and 287,137 controls. The research identified sixty-nine metabolites associated with varying degrees of risk enhancement or mitigation. For gastric cancer, a more focused discovery highlighted two metabolites with significant causal links-associated with increased risk as well as a protective effect. Sensitivity analyses confirmed the validity of these findings.</p><p><strong>Conclusion: </strong>By elucidating specific metabolites that exert direct causal effects on colorectal and gastric cancer risk, the study marked a significant advancement in the understanding of the metabolic pathways involved in cancer development.</p><p><strong>Key words: </strong>Mendelian randomisation, Colorectal cancer, Gastric cancer, Metabolites, Genetic variants, Genome-wide association studies, Causal inference.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 2","pages":"203-208"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143401121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inverted Total Shoulder Arthroplasty for Traumatic Shoulder Arthritis.
Pub Date : 2025-02-01 DOI: 10.29271/jcpsp.2025.02.263
Lin Zeng, Maimaitiyimin Mir Adili, Kan Jiang, Rongxin Sun

Null.

{"title":"Inverted Total Shoulder Arthroplasty for Traumatic Shoulder Arthritis.","authors":"Lin Zeng, Maimaitiyimin Mir Adili, Kan Jiang, Rongxin Sun","doi":"10.29271/jcpsp.2025.02.263","DOIUrl":"https://doi.org/10.29271/jcpsp.2025.02.263","url":null,"abstract":"<p><p>Null.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 2","pages":"263-264"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143401124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Karachi Faces Chikungunya Surge: Urgent Action Needed to Tackle Growing Health Crisis.
Pub Date : 2025-02-01 DOI: 10.29271/jcpsp.2025.02.258
Syed Ammar Salman, Rabiya Mahir, Javeria Hameed

Null.

{"title":"Karachi Faces Chikungunya Surge: Urgent Action Needed to Tackle Growing Health Crisis.","authors":"Syed Ammar Salman, Rabiya Mahir, Javeria Hameed","doi":"10.29271/jcpsp.2025.02.258","DOIUrl":"https://doi.org/10.29271/jcpsp.2025.02.258","url":null,"abstract":"<p><p>Null.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 2","pages":"258"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143401130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pain Management in a Tertiary Care Setup: Assessing Patient Satisfaction and Pain Relief.
Pub Date : 2025-02-01 DOI: 10.29271/jcpsp.2025.02.251
Muhammad Rashid Iqbal, Aijaz Ali, Mudassar Iqbal, Syed Majid Waseem, Moazam Ali Br, Muhammad Tahseen Talib

The aim of this study was to assess patient satisfaction and pain relief before and after interventions for chronic pain in a tertiary care pain clinic. It was a cross-sectional study, carried out in the Anaesthesia, Pain, and Intensive Care Department of the Combined Military Hospital, Rawalpindi, Pakistan, from January to July 2021. The patients were included in the study after obtaining an Ethical Committee Certificate and informed consents from the patients. The pain scores and patient satisfaction were measured before the procedure and after the procedure and comparisons were drawn with the help of Chi-square analysis with significance at less than 0.05. The mean visual analogue score recorded in the patients before the procedure was 8.9 ± 0.846. The mean visual analogue score (VAS) recorded after the procedure was 1.56 ± 1.328 at 10 minutes, 1.77 ± 1.535 at day three, and 3.13 ± 1.522 at three months with p-value of 0.28, 0.20, and 0.007, respectively. The patient satisfaction was 84.19 ± 13.89% at 10 minutes post-procedure, 83.08 ± 14.82% after three days, and 70.79 ± 44.5% after three months. Pain interventions provided reliable and satisfactory analgesia to patients with chronic pain who were refractory to pharmacological treatment. Moreover, chronic pain was prevalent in all adult age groups and pain interventions were effective in all age groups alike. Key Words: Intervention, Pain, Patient satisfaction, Visual analogue scale.

{"title":"Pain Management in a Tertiary Care Setup: Assessing Patient Satisfaction and Pain Relief.","authors":"Muhammad Rashid Iqbal, Aijaz Ali, Mudassar Iqbal, Syed Majid Waseem, Moazam Ali Br, Muhammad Tahseen Talib","doi":"10.29271/jcpsp.2025.02.251","DOIUrl":"https://doi.org/10.29271/jcpsp.2025.02.251","url":null,"abstract":"<p><p>The aim of this study was to assess patient satisfaction and pain relief before and after interventions for chronic pain in a tertiary care pain clinic. It was a cross-sectional study, carried out in the Anaesthesia, Pain, and Intensive Care Department of the Combined Military Hospital, Rawalpindi, Pakistan, from January to July 2021. The patients were included in the study after obtaining an Ethical Committee Certificate and informed consents from the patients. The pain scores and patient satisfaction were measured before the procedure and after the procedure and comparisons were drawn with the help of Chi-square analysis with significance at less than 0.05. The mean visual analogue score recorded in the patients before the procedure was 8.9 ± 0.846. The mean visual analogue score (VAS) recorded after the procedure was 1.56 ± 1.328 at 10 minutes, 1.77 ± 1.535 at day three, and 3.13 ± 1.522 at three months with p-value of 0.28, 0.20, and 0.007, respectively. The patient satisfaction was 84.19 ± 13.89% at 10 minutes post-procedure, 83.08 ± 14.82% after three days, and 70.79 ± 44.5% after three months. Pain interventions provided reliable and satisfactory analgesia to patients with chronic pain who were refractory to pharmacological treatment. Moreover, chronic pain was prevalent in all adult age groups and pain interventions were effective in all age groups alike. Key Words: Intervention, Pain, Patient satisfaction, Visual analogue scale.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 2","pages":"251-253"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rare Epithelioid Sarcoma of the Scalp Involving the Left Parietal Bone.
Pub Date : 2025-02-01 DOI: 10.29271/jcpsp.2025.02.261
Pengjuan Zhao, Wendong Xie, Guangsu Zhang, Chao Zhang

Null.

{"title":"Rare Epithelioid Sarcoma of the Scalp Involving the Left Parietal Bone.","authors":"Pengjuan Zhao, Wendong Xie, Guangsu Zhang, Chao Zhang","doi":"10.29271/jcpsp.2025.02.261","DOIUrl":"https://doi.org/10.29271/jcpsp.2025.02.261","url":null,"abstract":"<p><p>Null.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 2","pages":"261"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Open or Laparoscopic Hernia Repair? A Comparative Prospective Study in the Turkish Population.
Pub Date : 2025-02-01 DOI: 10.29271/jcpsp.2025.02.152
Mehmet Alperen Avci, Can Akgun, Suleyman Polat, Ahmet Burak Ciftci, Omer Faruk Buk, Emin Daldal

Objective: To investigate the impact of open (Lichtenstein) and laparoscopic techniques (transabdominal preperitoneal procedure (TAPP), and total extraperitoneal procedure (TEP)) for inguinal hernia repair, on quality of life within a heterogeneous patient population, and to compare the findings with the Turkish normative values.

Study design: An experimental study. Place and Duration of the Study: Department of General Surgery, Samsun University Training and Research Hospital, Samsun, Turkiye, from January to July 2023.

Methodology: Open and laparoscopic inguinal hernia repair techniques were prospectively compared using data from 128 patients, the SF-36 quality of life questionnaire. A comparison of the SF-36 questionnaire data was made with the normative physical and mental function values representative of the Turkish population.

Results: A total of 64 patients underwent open surgery, while another 64 received laparoscopic surgery through randomisation. No statistically significant differences were observed between the two groups regarding age, gender, complications, chronic pain, or quality of life. Compared to the normative values of the Turkish population, the laparoscopic technique demonstrated significantly better outcomes in women for physical functions (p <0.001) whereas the open technique showed significantly better results in men regarding role limitation due to emotional problems (p = 0.049).

Conclusion: For inguinal hernia repair in the Turkish population, the open technique may be recommended for male patients, while the laparoscopic technique may be more suitable for female patients. However, surgical expertise and the patients' clinical condition should also be taken into account when determining the appropriate surgical approach.

Key words: Lichtenstein, Transabdominal preperitoneal procedure, Total extraperitoneal procedure, Inguinal hernia, Quality of life, Short form 36.

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Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
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