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Quackery in Health is Still Around: Pseudoscientific Healing Practices Across the Globe. 江湖骗术在健康仍然存在:伪科学治疗实践在全球。
Pub Date : 2025-01-01 DOI: 10.29271/jcpsp.2025.01.83
Ghulam Yaseen Veesar, Ather Akhlaq, Ahson Qavi Siddiqi, Abdul Ghafoor Shoro

Fraudulent medical practices remain prevalent globally, fueled by digital platforms spreading false claims. This study analysed 3,327 published studies and 400 grey literature sources, selecting 38 studies and 19 excerpts for detailed examination. It identified 126 distinct quackery techniques and products used throughout history. Traditional methods are considered legitimate in Asian and African regions and dismissed as quackery in the West. In Western countries, quacks often use electricity, mechanical instruments, and gadgets for treatment. Historically, faith-based treatments are practised globally. However, these were limited to Asia and Africa. The rise of the internet has enabled quacks to exploit digital platforms to deceive and attract victims. These findings highlight the persistence of quackery and underscore the need for targeted strategies to combat these deceptive practices globally. Key Words: Charlatan, Illegal treatment, Medical fraud, Quackery.

在数字平台传播虚假声明的推动下,欺诈性医疗行为在全球仍然普遍存在。本研究分析了3327篇已发表的研究和400篇灰色文献来源,选取了38篇研究和19篇摘要进行了详细的考察。它确定了历史上使用的126种不同的骗术和产品。传统的方法在亚洲和非洲地区被认为是合法的,在西方被认为是骗人的。在西方国家,庸医经常使用电、机械器械和小工具进行治疗。从历史上看,基于信仰的治疗在全球范围内实行。然而,这些仅限于亚洲和非洲。互联网的兴起使得庸医们能够利用数字平台来欺骗和吸引受害者。这些发现强调了江湖骗术的持续存在,并强调了在全球范围内采取有针对性的策略来打击这些欺骗行为的必要性。关键词:江湖骗子;非法治疗;医疗欺诈;
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引用次数: 0
Treating Hidden Left Supraspinatus Calcific Tendinitis with Conventional Surgery. 常规手术治疗隐蔽性左冈上肌钙化肌腱炎。
Pub Date : 2025-01-01 DOI: 10.29271/jcpsp.2025.01.137
Guifu Ma, Wendong Xie, Ruixiong Nan, Xiufen Si

Null.

Null。
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引用次数: 0
Albumin Levels as Prognostic Markers in ICU Mortality. 白蛋白水平作为ICU死亡率的预后指标。
Pub Date : 2025-01-01 DOI: 10.29271/jcpsp.2025.01.30
Yakup Ozgungor, Hicret Yeniay, Kazim Rollas

Objective: To evaluate the association of serum albumin levels with short-term mortality in ICU patients, including ICU and 28-day mortality.

Study design: Observational study. Place and Duration of the Study: Intensive Care Unit, Izmir Tepecik Training and Research Hospital, Izmir, Turkiye, from January to July 2023.

Methodology: The study included 60 patients aged above 18 years who had stayed in the ICU for at least two days. Exclusion criteria were massive transfusion within the last 48 hours, septic shock with fluid resuscitation, liver failure at admission, end-stage renal disease, proteinuria, and BMI <18.5. The primary outcome included ICU mortality and 28-day mortality. Normality was assessed using the Shapiro-Wilk's test. A comparison between the quantitative data of the two studied groups was made with the independent samples t-test for normal distribution and for skewed data using the Mann-Whitney U test. A p-value of <0.05 was considered statistically significant.

Results: There was a significant association of both APACHE-II scores with ICU and 28-day mortality besides age and serum albumin level. In the binary logistic regression analysis, a statistically significant correlation was found between the albumin level at 48-hour and 28-day mortality (p <0.001).

Conclusion: Serum albumin levels at 48 hours post-admission were independent predictors of 28-day mortality.

Key words: Albumin, Critical care, Mortality.

目的:评价血清白蛋白水平与ICU患者短期死亡率(包括ICU和28天死亡率)的关系。研究设计:观察性研究。研究地点和时间:2023年1月至7月,土耳其伊兹密尔伊兹密尔Tepecik培训和研究医院重症监护室。方法:本研究纳入60例年龄在18岁以上且在ICU住院至少2天的患者。排除标准为48小时内大量输血、脓毒性休克合并液体复苏、入院时肝功能衰竭、终末期肾病、蛋白尿和BMI。结果:除了年龄和血清白蛋白水平外,APACHE-II评分与ICU和28天死亡率均有显著相关性。在二元logistic回归分析中,48小时白蛋白水平与28天死亡率之间存在统计学显著相关(p结论:入院后48小时血清白蛋白水平是28天死亡率的独立预测因子。关键词:白蛋白,重症监护,死亡率。
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引用次数: 0
The Role of 418 Gut Microbiota in Small Cell Lung Cancer Progression: A Mendelian Randomisation Study. 418肠道微生物群在小细胞肺癌进展中的作用:孟德尔随机研究
Pub Date : 2025-01-01 DOI: 10.29271/jcpsp.2025.01.60
Rui Gong, Haiyang Li

Objective: To investigate the causal influence of gut microbiota on small cell lung cancer (SCLC) progression using Mendelian randomisation (MR), providing insights into the gut-lung axis in lung cancer pathology.

Study design: Analytical study. Place and Duration of the Study: Department of Radiotherapy, Binhai County People's Hospital, Yancheng, Jiangsu, China, and Department of Paediatrics, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China, from January to May 2024.

Methodology: The study used 18,340 single nucleotide polymorphisms (SNPs) as instrumental variables to analyse 418 gut microbiota varieties. The inverse variance weighted (IVW) and MR Egger's methods were applied to explore causal relationships. Sensitivity analyses, including leave-one-out tests and Cochrane's Q tests, ensured robust results. A uni-directional Mendelian randomisation (MR) analysis was conducted using summary statistics from genome-wide association studies (GWAS) provided by the MiBio-Gen and Finn-Gen consortia.

Results: MR identified several bacterial taxonomic groups significantly associated with SCLC risk. Protective factors included Bacteroidetes (p = 0.0154), Eubacterium ruminantium group (p = 0.0241), Barnesiella (p = 0.0015), Clostridia (p = 0.0242), Christensenellaceae (p = 0.0314), Ruminococcaceae UCG-003 (p = 0.0381), and an unknown genus in the Ruminococcaceae family (p = 0.0458). Conversely, the risk factors linked to increased SCLC risk included Firmicutes (p = 0.0456), Pasteurellaceae (p = 0.0177), Eubacterium oxidoreducens group (p = 0.0188), Pasteurellales (p = 0.0177), and Alcaligenaceae (p = 0.0423).

Conclusion: The study suggests a protective role of specific gut microbiota against SCLC and identifies others that may increase the risk. The absence of heterogeneity and pleiotropy supports the causal associations, underscoring the significance of the gut-lung axis in SCLC and the utility of MR in cancer epidemiology.

Key words: Small cell lung cancer, Gut microbiota, Mendelian randomisation, Causal inference, Cancer epidemiology.

目的:利用孟德尔随机化(MR)研究肠道微生物群对小细胞肺癌(SCLC)进展的因果影响,为肺癌病理中的肠-肺轴提供见解。研究设计:分析性研究。研究地点和时间:中国江苏省盐城市滨海县人民医院放疗科和宁夏医科大学银川市总医院儿科,中国宁夏,2024年1月- 5月。方法:该研究使用18340个单核苷酸多态性(snp)作为工具变量,分析了418个肠道微生物群品种。采用逆方差加权(IVW)和MR Egger的方法来探索因果关系。敏感性分析,包括遗漏测试和Cochrane’s Q测试,确保了可靠的结果。使用由MiBio-Gen和fin - gen联盟提供的全基因组关联研究(GWAS)的汇总统计数据进行单向孟德尔随机化(MR)分析。结果:MR鉴定出几个与SCLC风险显著相关的细菌分类群。保护因子包括拟杆菌门(p = 0.0154)、反刍真杆菌群(p = 0.0241)、巴氏杆菌(p = 0.0015)、梭状芽孢杆菌(p = 0.0242)、Christensenellaceae (p = 0.0314)、Ruminococcaceae UCG-003 (p = 0.0381)和Ruminococcaceae科一个未知属(p = 0.0458)。相反,与SCLC风险增加相关的危险因素包括厚壁菌门(p = 0.0456)、巴氏杆菌科(p = 0.0177)、氧化还原真杆菌组(p = 0.0188)、巴氏杆菌(p = 0.0177)和Alcaligenaceae (p = 0.0423)。结论:该研究提示了特定肠道微生物群对SCLC的保护作用,并确定了其他可能增加风险的微生物群。异质性和多效性的缺失支持了因果关系,强调了SCLC中肠-肺轴的重要性以及MR在癌症流行病学中的应用。关键词:小细胞肺癌,肠道菌群,孟德尔随机化,因果推断,癌症流行病学
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引用次数: 0
Chicago Sky Blue Stain, Calcofluor White Stain, and Potassium Hydroxide Mount for Diagnosis of Dermatomycosis.
Pub Date : 2025-01-01 DOI: 10.29271/jcpsp.2025.01.44
Aleena Khalid, Maria Mushtaq Gill, Mahvish Aftab Khan, Sakeenah Hussain Naqvi, Muhammad Roshan, Anam Imtiaz

Objective: To evaluate Chicago Sky Blue (CSB) stain, Calcofluor white (CW) stain, and Potassium Hydroxide (KOH) mount for rapid diagnosis of dermatomycosis, using fungal culture as the gold standard.

Study design: Cross-sectional analytical study. Place and Duration of the Study: This study was conducted in the Department of Microbiology, Armed Forces Institute of Pathology / National University of Medical Sciences, Rawalpindi, Pakistan, from July 2023 to February 2024.

Methodology: Clinical specimens were collected from patients suspected of having dermatomycosis, including skin scrapings, hair, and nails. Each sample was divided into two parts. The first part underwent three microscopic techniques, namely 10% KOH mount, CSB stain, and CW stain. The presence and absence of hyphae were noted by each of the techniques. Second part was inoculated onto Sabouraud Dextrose agar (SDA) with and without antibiotics, along with Dermatophyte test medium (DTM). Culture plates were incubated at 30o C for four weeks. True-positive, true-negative, and diagnostic accuracy of the microscopy methods were calculated against fungal culture.

Results: Out of 121 patients, the majority were females constituting 65.3% (n = 79) while males were 34.7% (n = 42). The average age of participants was 32.98 ± 16 years. Diagnostic accuracy was 82.6% for CSB, 87.6% for CW stain, and 76.8% for 10% KOH mount.

Conclusion: CW stain proved to be superior to 10% KOH mount and CSB stain for rapid dermatomycosis diagnosis, with enhanced sensitivity and diagnostic accuracy. Both CW and CSB stains are recommended for laboratory use to improve reporting accuracy as compared to the conventional 10% KOH mount technique.

Key words: Calcofluor white, Chicago sky blue, Dermatomycosis, Fungal culture, Fungal hyphae.

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引用次数: 0
The Role of Preoperative Inflammatory Markers in Cervical Cerclage Success. 术前炎症标志物在宫颈环扎术成功中的作用。
Pub Date : 2025-01-01 DOI: 10.29271/jcpsp.2025.01.55
Gulten Ozgen, Levent Ozgen, Burcu Dincgez, Berin Ozyamaci

Objective: To compare the inflammatory markers between therapeutic and emergency cerclage and assess the predictive role of inflammatory markers for the latency period.

Study design: Descriptive study. Place and Duration of the Study: Department of Obstetrics and Gynaecology, Bursa Yuksek Ihtisas Training and Research Hospital, Turkiye, from January 2016 to September 2022.

Methodology: The therapeutic cerclage group (n = 64) included patients with a history of cervical insufficiency, normal prenatal screening test results, and who underwent cerclage based on history indications. The emergency cerclage group (n = 14) included patients with painless cervical dilation in the second trimester or a history of preterm and a short cervix on ultrasonography. Exclusion criteria composed of multiple pregnancies, active uterine contractions, vaginal bleeding, chorioamnionitis, membrane rupture, foetal anomalies, history of conization or abdominal cerclage, and having inflammatory diseases. Sociodemographic features, perinatal outcomes, and inflammatory markers such as neutrophil-to-lymphocyte ratio, C-reactive protein, and systemic immune-inflammation index were compared. Systemic immune-inflammation index was calculated by formulating the multiplication value of the neutrophil and platelet count divided by the lymphocyte count.

Results: The latency period was shorter (5.5 (0-29) vs. 20 (1-31) weeks, p <0.001) in the emergency cerclage group. Neutrophil-to- lymphocyte ratio and systemic immune-inflammation index, which are representatives of increased inflammatory state, were significantly higher in the emergency cerclage group (p = 0.007 for both). Systemic immune-inflammation index was correlated with cerclage to delivery interval for all patients (r = -0.307, p = 0.006). Also, it predicted neonatal mortality with a cut-off value of 1078.08, 90% sensitivity and 70.59% specificity (AUC = 0.776, p <0.001) and low Apgar scores with 57.1% sensitivity and 74% specificity (AUC = 0.641, p = 0.038).

Conclusion: Systemic immune-inflammation index, correlated with cerclage to delivery interval, could be a marker for predicting neonatal mortality and morbidity in cerclage patients.

Key words: Cervical cerclage, Inflammatory markers, Perinatal outcomes, Systemic immune-inflammation index.

目的:比较治疗性和急诊性环扎术的炎症标志物,评价炎症标志物对潜伏期的预测作用。研究设计:描述性研究。研究地点和时间:2016年1月至2022年9月,土耳其Bursa Yuksek Ihtisas培训和研究医院妇产科。方法:治疗性环扎术组(n = 64)包括宫颈功能不全病史、产前筛查结果正常、根据病史指征行环扎术的患者。急诊环切组(n = 14)包括妊娠中期无痛宫颈扩张或有早产史且超声检查宫颈短的患者。排除标准包括多胎妊娠、子宫活跃收缩、阴道出血、绒毛膜羊膜炎、膜破裂、胎儿异常、锥形或腹部环扎史、有炎症性疾病。比较社会人口学特征、围产期结局和炎症标志物,如中性粒细胞与淋巴细胞比率、c反应蛋白和全身免疫炎症指数。系统免疫炎症指数由中性粒细胞和血小板计数的倍增值除以淋巴细胞计数计算。结果:潜伏期短(5.5 (0-29)vs. 20(1-31)周。p结论:全身免疫炎症指数与环扎术至分娩间隔相关,可作为预测环扎术患者新生儿死亡率和发病率的指标。关键词:宫颈环扎,炎症标志物,围产期结局,全身免疫炎症指数。
{"title":"The Role of Preoperative Inflammatory Markers in Cervical Cerclage Success.","authors":"Gulten Ozgen, Levent Ozgen, Burcu Dincgez, Berin Ozyamaci","doi":"10.29271/jcpsp.2025.01.55","DOIUrl":"https://doi.org/10.29271/jcpsp.2025.01.55","url":null,"abstract":"<p><strong>Objective: </strong>To compare the inflammatory markers between therapeutic and emergency cerclage and assess the predictive role of inflammatory markers for the latency period.</p><p><strong>Study design: </strong>Descriptive study. Place and Duration of the Study: Department of Obstetrics and Gynaecology, Bursa Yuksek Ihtisas Training and Research Hospital, Turkiye, from January 2016 to September 2022.</p><p><strong>Methodology: </strong>The therapeutic cerclage group (n = 64) included patients with a history of cervical insufficiency, normal prenatal screening test results, and who underwent cerclage based on history indications. The emergency cerclage group (n = 14) included patients with painless cervical dilation in the second trimester or a history of preterm and a short cervix on ultrasonography. Exclusion criteria composed of multiple pregnancies, active uterine contractions, vaginal bleeding, chorioamnionitis, membrane rupture, foetal anomalies, history of conization or abdominal cerclage, and having inflammatory diseases. Sociodemographic features, perinatal outcomes, and inflammatory markers such as neutrophil-to-lymphocyte ratio, C-reactive protein, and systemic immune-inflammation index were compared. Systemic immune-inflammation index was calculated by formulating the multiplication value of the neutrophil and platelet count divided by the lymphocyte count.</p><p><strong>Results: </strong>The latency period was shorter (5.5 (0-29) vs. 20 (1-31) weeks, p <0.001) in the emergency cerclage group. Neutrophil-to- lymphocyte ratio and systemic immune-inflammation index, which are representatives of increased inflammatory state, were significantly higher in the emergency cerclage group (p = 0.007 for both). Systemic immune-inflammation index was correlated with cerclage to delivery interval for all patients (r = -0.307, p = 0.006). Also, it predicted neonatal mortality with a cut-off value of 1078.08, 90% sensitivity and 70.59% specificity (AUC = 0.776, p <0.001) and low Apgar scores with 57.1% sensitivity and 74% specificity (AUC = 0.641, p = 0.038).</p><p><strong>Conclusion: </strong>Systemic immune-inflammation index, correlated with cerclage to delivery interval, could be a marker for predicting neonatal mortality and morbidity in cerclage patients.</p><p><strong>Key words: </strong>Cervical cerclage, Inflammatory markers, Perinatal outcomes, Systemic immune-inflammation index.</p>","PeriodicalId":94116,"journal":{"name":"Journal of the College of Physicians and Surgeons--Pakistan : JCPSP","volume":"35 1","pages":"55-59"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reversion of Supra-Ventricular Tachycardia Through High Positive End-Expiratory Pressure During Mechanical Ventilation in Critically Ill Patients. 危重病人机械通气时高呼气末正压对室上性心动过速的逆转作用。
Pub Date : 2025-01-01 DOI: 10.29271/jcpsp.2025.01.125
Hongbo Wu, Shouyin Jiang, Shanxiang Xu, Xiao Lu

The Valsalva manoeuvre is widely recognised for its effectiveness in reverting supra-ventricular tachycardia (SVT) in patients with good coordination. However, this is not applicable in sedated ventilated patients and there is a dearth of literature regarding the application of Valsalva in unconscious patients on mechanical ventilation. The authors, for the first time, present a novel non-pharmacological method to treat SVT in critically ill patients on mechanical ventilation, employing the high positive end-expiratory pressure (PEEP) technique. This method successfully reverted SVT in two patients. While the exact mechanism remains unconfirmed, it is believed to be similar to that of the Valsalva manoeuvre. Further research is needed to validate this technique and determine the optimal ventilator settings, including the PEEP threshold, for such cases. Key Words: Valsalva manoeuvre, Supraventricular tachycardia, Positive end-expiratory pressure, Mechanical ventilation.

Valsalva在恢复室性心动过速(SVT)方面的有效性被广泛认可。然而,这并不适用于镇静通气患者,并且缺乏关于Valsalva在无意识患者机械通气中的应用的文献。作者首次提出了一种新的非药物方法来治疗机械通气危重患者的SVT,采用高呼气末正压(PEEP)技术。该方法成功地恢复了2例患者的SVT。虽然确切的机制尚未得到证实,但据信它与瓦尔萨尔瓦演习类似。需要进一步的研究来验证该技术,并确定此类病例的最佳呼吸机设置,包括PEEP阈值。关键词:Valsalva手法,室上性心动过速,呼气末正压,机械通气。
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引用次数: 0
Clinical Outcomes of Definitive Radiotherapy Delivered by Helical Tomotherapy. 螺旋断层放射治疗的临床疗效。
Pub Date : 2025-01-01 DOI: 10.29271/jcpsp.2025.01.66
Fatima Shaukat, Yumna Ahmed, Rabia Tahseen, Tariq Mahmood

Objective: To assess the disease response and patient survival outcomes for cancer patients treated with helical tomotherapy.

Study design: Descriptive study. Place and Duration of the Study: The Tomotherapy Unit of Jinnah Postgraduate Medical Centre, Karachi, Pakistan, from October 2020 to August 2023.

Methodology: A retrospective analysis was conducted on the data of patients who underwent definitive radiation at Tomotherapy Centre. The evaluation of disease response utilised CT scans performed three months after completing radiotherapy, following RECIST criteria. Survival and disease-free status were determined through telephonic interviews with the patients.

Results: A total of 654 patients received treatment on Tomotherapy, of which, 143 underwent definitive Radiotherapy. The average age was 51 ± 16.8 years, with 85 (59.4%) males. The predominant area subjected to definitive radiation was the head and neck, accounting for 65 cases (45.5%), trailed by the gastrointestinal tract and pelvis with 52 (36.4%) and 26 (18.2%) cases, respectively. Response assessment revealed a complete response in 73 (52.14%) patients, partial response in 47 (33.5%), stable disease in 11 (7.85%), and progressive disease in 9 (6.4%). Currently, 108 (77%) patients are alive. Twenty-eight (20%) patients experienced local or distant disease development. Among them, 6 (4.3%) patients had local recurrence, and 22 (15.7%) developed metastatic disease.

Conclusion: Helical tomotherapy offers promising disease control and survival outcomes, making it a viable treatment modality for cancer patients in a lower middle-income country. These findings highlight the importance of careful patient selection and optimising resource utilisation for curative treatments to enhance cancer care in Pakistan.

Key words: Radiotherapy, Tomotherapy, Radiotherapy technique, Multidisciplinary treatment, Peer-review practice.

目的:评价螺旋断层治疗对肿瘤患者的疗效和生存预后。研究设计:描述性研究。研究地点和时间:2020年10月至2023年8月,在巴基斯坦卡拉奇真纳研究生医学中心断层治疗部。方法:回顾性分析在断层治疗中心接受最终放射治疗的患者资料。根据RECIST标准,在放疗完成三个月后,利用CT扫描评估疾病反应。通过电话访谈确定患者的生存和无病状态。结果:654例患者接受了ct治疗,其中143例患者接受了最终放疗。平均年龄51±16.8岁,男性85例(59.4%)。明确放疗部位以头颈部为主,占65例(45.5%),其次为胃肠道和骨盆,分别为52例(36.4%)和26例(18.2%)。反应评估显示73例(52.14%)患者完全缓解,47例(33.5%)患者部分缓解,11例(7.85%)患者病情稳定,9例(6.4%)患者病情进展。目前,108例(77%)患者存活。28例(20%)患者出现局部或远处病变。其中局部复发6例(4.3%),转移性疾病22例(15.7%)。结论:螺旋断层治疗提供了有希望的疾病控制和生存结果,使其成为中低收入国家癌症患者的可行治疗方式。这些发现强调了仔细选择患者和优化治愈性治疗资源利用的重要性,以加强巴基斯坦的癌症护理。关键词:放疗,断层治疗,放疗技术,多学科治疗,同行评议实践
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引用次数: 0
Serum Thyroglobulin as a Marker for Differential Diagnosis of Hyperthyroidism. 血清甲状腺球蛋白作为甲状腺机能亢进的鉴别诊断指标。
Pub Date : 2025-01-01 DOI: 10.29271/jcpsp.2025.01.39
Fatimah Javaid Qureshi, Muhammad Anwar, Muhammad Qaiser Alam Khan, Muhammad Younas, Zaigham Salim Dar, Sajida Shaheen

Objective: To evaluate the role of serum thyroglobulin (TG) as a biochemical marker for differential diagnosis of common aetiologies of hyperthyroidism.

Study design: Comparative cross-sectional study. Place and Duration of the Study: Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology (AFIP), Rawalpindi, Pakistan, from October 2023 to March 2024.

Methodology: One hundred and forty-eight patients with clinical or biochemical hyperthyroidism were enrolled in the study. Samples were taken for serum thyroglobulin and evaluated for different causes of hyperthyroidism as demonstrated on the thyroid scan. Serum TG levels were measured using a chemiluminescence immunoassay and levels >42 ng/ml were considered elevated. Relationship between TG levels and different causes of hyperthyroidism was determined via independent samples non-parametric Kruskal-Wallis test.

Results: The study found that 76.3% (n = 113) of patients had raised TG levels, with significant differences in median TG levels observed among the different hyperthyroidism aetiologies. Thyroiditis exhibited the highest median TG levels (202.5 ng/ml), followed by toxic adenoma (139 ng/ml) and toxic multinodular goitre (102 ng/ml), while Graves' disease had the lowest levels (34 ng/ml). Sensitivity of thyroglobulin to detect thyroid disease was 76% while specificity came out to be 100%. Positive predictive value (PPV) was 100% while negative predictive value (NPV) was 20.45%.

Conclusion: Serum TG levels vary markedly among different aetiologies of hyperthyroidism with the highest levels in thyroiditis and the lowest in Graves' disease.

Key words: Thyroglobulin, Hyperthyroidism, Graves' disease, Thyroiditis.

目的:探讨血清甲状腺球蛋白(TG)作为生化指标在甲状腺机能亢进常见病因鉴别诊断中的作用。研究设计:比较横断面研究。研究地点和时间:2023年10月至2024年3月,巴基斯坦拉瓦尔品第武装部队病理研究所(AFIP)化学病理和内分泌学系。方法:148例临床或生化甲状腺功能亢进患者被纳入研究。样品被采取血清甲状腺球蛋白和评估不同原因的甲状腺机能亢进显示在甲状腺扫描。采用化学发光免疫分析法测定血清TG水平,认为> ~ 42 ng/ml水平升高。通过独立样本非参数Kruskal-Wallis检验确定TG水平与甲亢不同病因的关系。结果:研究发现76.3% (n = 113)的患者TG水平升高,不同甲状腺功能亢进病因中位TG水平差异显著。甲状腺炎中位TG水平最高(202.5 ng/ml),其次是中毒性腺瘤(139 ng/ml)和中毒性多结节甲状腺(102 ng/ml), Graves病中位TG水平最低(34 ng/ml)。甲状腺球蛋白检测甲状腺疾病的敏感性为76%,特异性为100%。阳性预测值为100%,阴性预测值为20.45%。结论:不同病因甲亢患者血清TG水平差异显著,甲状腺炎患者血清TG水平最高,Graves病患者血清TG水平最低。关键词:甲状腺球蛋白,甲亢,格雷夫斯病,甲状腺炎
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引用次数: 0
Sweet Syndrome: A Retrospective Analysis of 21 Patients. 甜综合征21例回顾性分析。
Pub Date : 2025-01-01 DOI: 10.29271/jcpsp.2025.01.128
Yun Wang, Quansheng Lu, Pengfei Pan, Ran Fu, Guan Jiang

Sweet syndrome, also known as acute febrile neutrophilic dermatosis, is a rare condition characterised by fever, leucocytosis, and painful skin lesions. This retrospective study analysed 21 patients with Sweet syndrome treated at the Affiliated Hospital of Xuzhou Medical University from January 2015 to June 2022. The study aimed to investigate the aetiology, clinicopathological features, and treatment outcomes. The majority of patients were female, with a median age of 54 years. Upper respiratory tract infection was identified as a common predisposing factor. Histopathological examination revealed neutrophilic infiltration without leucocytoclastic vasculitis. Treatment with glucocorticoids and glycyrrhizin was effective in managing the condition. Key Words: Sweet syndrome, Clinical analysis, Treatment, Glucocorticoids.

Sweet综合征,也被称为急性发热性中性粒细胞皮肤病,是一种罕见的疾病,其特征是发热、白细胞增多和皮肤病变疼痛。本回顾性研究分析了2015年1月至2022年6月在徐州医科大学附属医院治疗的21例Sweet综合征患者。本研究旨在探讨该病的病因、临床病理特征和治疗效果。患者以女性为主,中位年龄54岁。上呼吸道感染被认为是常见的易感因素。组织病理学检查显示中性粒细胞浸润,无白细胞破溃性血管炎。糖皮质激素和甘草酸治疗对控制病情有效。关键词:甜证,临床分析,治疗,糖皮质激素
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引用次数: 0
期刊
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
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