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[Cystic lesions of the pancreas]. [胰腺的囊性病变]。
La Revue du praticien
Pub Date : 2025-10-01
Clémence Descourvières, Vinciane Rebours

CYSTIC LESIONS OF THE PANCREAS. The practice of every gastroenterologist is daily punctuated by the management of patients with pancreatic cystic lesions (PCL). The discovery is usually fortuitous and the lesions in majority are small (less than 10mm). The prevalence of PCL in the general population of adults is very high and probably greater than 40% if we consider lesions of 2 mm. Some PCL are precancerous lesions, (as intraductal papillary mucinous neoplasm [IPMN]) with a real risk of pancreatic adenocarcinoma and others cystic lesions have a risk of metastases such as pseudopapillary and solid tumors or cystic neuroendocrine tumors. The follow-up protocol, recommended by international experts, is highly debated because it is expensive, potentially invasive (in case of repeated use of endoscopic ultrasound) and not perfect. Only a few patients will develop aggressive and potentially invasive lesions. However, the lack of specific diagnostic tools for the grade of dysplasia and the mortality rate of pancreatic cancer leads European experts to recommend regular monitoring.

胰腺的囊性病变每个胃肠病学家的实践是每天被胰腺囊性病变（PCL）患者的管理打断。发现通常是偶然的，大多数病变很小（小于10mm）。PCL在普通成年人中的患病率非常高，如果考虑到2毫米的病变，患病率可能超过40%。一些PCL是癌前病变（如导管内乳头状粘液瘤[IPMN]），具有胰腺腺癌的真正风险，而其他囊性病变有转移的风险，如假乳头状瘤和实体瘤或囊性神经内分泌肿瘤。由国际专家推荐的后续治疗方案存在高度争议，因为它价格昂贵，具有潜在的侵入性（在反复使用内窥镜超声的情况下），而且并不完美。只有少数患者会发展为侵袭性和潜在的侵袭性病变。然而，由于缺乏针对胰腺癌发育不良程度和死亡率的特定诊断工具，欧洲专家建议定期监测。
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引用次数: 0
[Imaging of subarachnoid hemorrhage]. [蛛网膜下腔出血成像]。
La Revue du praticien
Pub Date : 2025-10-01
Finoana Laza Nomenjanahary, Aurélien Mazeraud, Hugo Gortais, Anne-Charlotte De Rycke, Denis Trystram, Christine Rodriguez, Wagih Ben Hassen, Johan Pallud, Olivier Naggara
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引用次数: 0
[Newborn screening for cystic fibrosis]. [新生儿囊性纤维化筛查]。
La Revue du praticien
Pub Date : 2025-10-01
Thao N Guyen, Anne-Sophie Bonnel, Isabelle Sermet-Gaudelus

NEWBORN SCREENING FOR CYSTIC FIBROSIS. Neonatal screening for cystic fibrosis enables pre-symptomatic identification of infants with cystic fibrosis. The challenge for the multidisciplinary team at the cystic fibrosis resource and competence centers is to set up a medical follow-up program to prevent nutritional and respiratory complications. Neonatal screening also identifies a cohort of newborns with suspected cystic fibrosis who do not meet the classic criteria for the disease. These non-conclusive forms do not have a clearly established prognosis or management.

新生儿囊性纤维化筛查。新生儿囊性纤维化筛查能够在症状前识别患有囊性纤维化的婴儿。囊性纤维化资源和能力中心的多学科团队面临的挑战是建立一个医疗随访计划，以预防营养和呼吸并发症。新生儿筛查还确定了一组疑似囊性纤维化但不符合该疾病经典标准的新生儿。这些非结论性形式没有明确的预后或治疗方法。
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引用次数: 0
[Treatment perspectives for patients not eligible for therapies for cystic fibrosis]. [不适合囊性纤维化治疗的患者的治疗前景]。
La Revue du praticien
Pub Date : 2025-10-01
Emmanuelle Bardin, Iwona Pranke, Marie Giorgi, Mairead Kelly-Aubert, Isabelle Sermet-Gaudelus

TREATMENT PERSPECTIVES FOR PATIENTS NOT ELIGIBLE FOR PROTEIN THERAPIES FOR CYSTIC FIBROSIS. The vast majority of patients with cystic fibrosis can benefit from proteic therapy. 10% of patients remain without therapeutic access. RNA editing strategies such as antisense oligonucleotides for specific splice mutations or RNA editing are now in the clinical phase. Gene therapy, DNA editing or readthrough therapies face numerous challenges in terms of vectorization and efficiency. Strong interactions between academic laboratories, harmaceutical industries, associations and health authorities may be unable to consider that in the near future, cystic fibrosis is no longer a f atal disease.

囊性纤维化不适合蛋白治疗的患者的治疗前景。绝大多数囊性纤维化患者可以从蛋白质治疗中获益。10%的患者仍然无法获得治疗。RNA编辑策略，如针对特定剪接突变的反义寡核苷酸或RNA编辑，目前处于临床阶段。基因治疗、DNA编辑或读取疗法在矢量化和效率方面面临着许多挑战。学术实验室、制药行业、协会和卫生当局之间的密切互动可能无法考虑到，在不久的将来，囊性纤维化不再是一种致命的疾病。
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引用次数: 0
[Trends in cancer incidence in France]. [法国癌症发病率趋势]。
La Revue du praticien
Pub Date : 2025-10-01
Hill Catherine
{"title":"[Trends in cancer incidence in France].","authors":"Hill Catherine","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":94123,"journal":{"name":"La Revue du praticien","volume":"75 8","pages":"827-829"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Demons-Meigs syndrome]. (Demons-Meigs综合症)。
La Revue du praticien
Pub Date : 2025-10-01
Aboubakr Benjilany, Khalid Guelzim, Moulay El Mehdi El Hassani, Jaouad Kouach
{"title":"[Demons-Meigs syndrome].","authors":"Aboubakr Benjilany, Khalid Guelzim, Moulay El Mehdi El Hassani, Jaouad Kouach","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":94123,"journal":{"name":"La Revue du praticien","volume":"75 8","pages":"874-875"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cystic fibrosis: 10 key messages]. [囊性纤维化：10个关键信息]。
La Revue du praticien
Pub Date : 2025-10-01
Isabelle Durieu
{"title":"[Cystic fibrosis: 10 key messages].","authors":"Isabelle Durieu","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":94123,"journal":{"name":"La Revue du praticien","volume":"75 8","pages":"870"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Archeology of sleep : sleeping through human evolution]. [睡眠考古学：人类进化中的睡眠]。
La Revue du praticien
Pub Date : 2025-10-01
Philippe Charlier
{"title":"[Archeology of sleep : sleeping through human evolution].","authors":"Philippe Charlier","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":94123,"journal":{"name":"La Revue du praticien","volume":"75 8","pages":"843-844"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Corticosteroid-induced lumbar shingles in a child]. [皮质类固醇诱发的儿童腰椎带状疱疹]。
La Revue du praticien
Pub Date : 2025-10-01
Khadija Kaddar, Ouissal Hormi, Nada Tahri, Nassiba Zerrouki, Nada Zizi
{"title":"[Corticosteroid-induced lumbar shingles in a child].","authors":"Khadija Kaddar, Ouissal Hormi, Nada Tahri, Nassiba Zerrouki, Nada Zizi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":94123,"journal":{"name":"La Revue du praticien","volume":"75 8","pages":"876-877"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Subarachnoid hemorrhage]. 蛛网膜下腔出血。
La Revue du praticien
Pub Date : 2025-10-01
Finoana Laza Nomenjanahary, Aurélien Mazeraud, Hugo Gortais, Anne-Charlotte De Rycke, Denis Trystram, Christine Rodriguez, Wagih Ben Hassen, Johan Pallud, Olivier Naggara
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引用次数: 0
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