LOW PHOSPHOLIPIDASSOCIATED CHOLELITHIASIS (LPAC) SYNDROME. LPAC (low phospholipid-associated cholelithiasis) syndrome is a rare genetic form of intrahepatic cholelithiasis, associated in 30% to 50% of cases with a pathogenic variant of the phospholipid transporter MDR3 (multidrug resistance protein 3). Clinical presentation of LPAC syndrome is similar to that of common cholelithiasis, but young adult onset of symptoms (before the age of 40) and recurrence of biliary symptoms after cholecystectomy are highly suggestive of the syndrome. Ultrasound of the liver is key for diagnosis, showing intrahepatic microlithiasis in the form of ductal comet-tail images or microspots. Ursodeoxycholic acid (UDCA), at a dose of 5 to 15 mg/kg/d, is the reference treatment. Endoscopic treatment of lithiasis of the common main bile duct and/ or the main hepatic ducts is sometimes necessary.
{"title":"[Low phospholipidassociated cholelithiasis syndrome].","authors":"Pierre-Antoine Soret, Olivier Chazouillères, Christophe Corpechot","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>LOW PHOSPHOLIPIDASSOCIATED CHOLELITHIASIS (LPAC) SYNDROME. LPAC (low phospholipid-associated cholelithiasis) syndrome is a rare genetic form of intrahepatic cholelithiasis, associated in 30% to 50% of cases with a pathogenic variant of the phospholipid transporter MDR3 (multidrug resistance protein 3). Clinical presentation of LPAC syndrome is similar to that of common cholelithiasis, but young adult onset of symptoms (before the age of 40) and recurrence of biliary symptoms after cholecystectomy are highly suggestive of the syndrome. Ultrasound of the liver is key for diagnosis, showing intrahepatic microlithiasis in the form of ductal comet-tail images or microspots. Ursodeoxycholic acid (UDCA), at a dose of 5 to 15 mg/kg/d, is the reference treatment. Endoscopic treatment of lithiasis of the common main bile duct and/ or the main hepatic ducts is sometimes necessary.</p>","PeriodicalId":94123,"journal":{"name":"La Revue du praticien","volume":"75 9","pages":"1003-1009"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Caring for carers to better care for patients].","authors":"Sophie De Guibert, Roch Houot","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":94123,"journal":{"name":"La Revue du praticien","volume":"75 9","pages":"938-940"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[NetSarc: a French ambition].","authors":"Jean-Yves Blay","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":94123,"journal":{"name":"La Revue du praticien","volume":"75 9","pages":"931"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Sarcomas and devices for adolescents and young adults].","authors":"Cyril Lervat","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":94123,"journal":{"name":"La Revue du praticien","volume":"75 9","pages":"981-982"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
VIRAL HEPATITIS AND PREGNANCY. The event of pregnancy, the risks of obstetrical complications and vertical transmission will vary according to the type of viral hepatitis. Hepatitis A is transmitted via feacal-oral transmisson, is generally mild, but may increase the risk of obstetric complications. Hepatitis B, the most common, can be transmitted from mother to child, particularly during delivery. Its management includes prenatal screening and antiviral treatment to prevent vertical transmission. Hepatitis C is mainly blood-borne. Hepatitis D superinfects those with HBV, with limited treatment options during pregnancy. Hepatitis E, common in low-income countries, is severe particularly in the third trimester, and may lead to fulminant hepatitis. Mother-to-child transmission is rare for all these viruses, and breastfeeding is generally permitted.
{"title":"[Viral hepatitis and pregnancy].","authors":"Imane Ben M'Barek, Jeanne Sibiude, Élise Bouthry","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>VIRAL HEPATITIS AND PREGNANCY. The event of pregnancy, the risks of obstetrical complications and vertical transmission will vary according to the type of viral hepatitis. Hepatitis A is transmitted via feacal-oral transmisson, is generally mild, but may increase the risk of obstetric complications. Hepatitis B, the most common, can be transmitted from mother to child, particularly during delivery. Its management includes prenatal screening and antiviral treatment to prevent vertical transmission. Hepatitis C is mainly blood-borne. Hepatitis D superinfects those with HBV, with limited treatment options during pregnancy. Hepatitis E, common in low-income countries, is severe particularly in the third trimester, and may lead to fulminant hepatitis. Mother-to-child transmission is rare for all these viruses, and breastfeeding is generally permitted.</p>","PeriodicalId":94123,"journal":{"name":"La Revue du praticien","volume":"75 9","pages":"111-1014"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Contributions of molecular biology to sarcomas].","authors":"Sarah Watson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":94123,"journal":{"name":"La Revue du praticien","volume":"75 9","pages":"963"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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