Neurologia最新文献

{"title":"Status of neurosonology in Spain. A study from the Spanish Society of Neurosonology (SONES)","authors":"J. Rodríguez-Pardo ,&nbsp;J. Carneado-Ruiz ,&nbsp;M. Martínez-Martínez ,&nbsp;J.M. Moltó-Jordá ,&nbsp;P. Irimia ,&nbsp;J. Serena-Leal ,&nbsp;Ó. Ayo-Martín ,&nbsp;P. Martínez-Sánchez ,&nbsp;J. Pagola ,&nbsp;J. Fernández-Domínguez ,&nbsp;on behalf of the Spanish Society of Neurosonology (SONES)","doi":"10.1016/j.nrleng.2025.06.003","DOIUrl":"10.1016/j.nrleng.2025.06.003","url":null,"abstract":"<div><h3>Introduction</h3><div>Neurosonology is the field of study of the ultrasound techniques applied to neurological diseases. The Spanish Society of Neurosonology (SONES) was funded in 1997 to promote training and education in these techniques, especially focused on the study of cerebrovascular diseases. After 25 years, the increased use of other advanced neurovascular imaging techniques and the emergence of novel applications of ultrasound in other fields of neurology, have modified the classic role of neurosonology. From the SONES we aimed to evaluate the current status of neurosonology in Spain.</div></div><div><h3>Methods</h3><div>Cross-sectional survey of neurologists and neurology residents working in Spain regarding training, education, and local daily practice, including a strengths, weaknesses, opportunities and threats (SWOT) analysis.</div></div><div><h3>Results</h3><div>One-hundred seventy-eight neurologists and thirty-four neurology residents participated in the survey. A wide experience in vascular neurosonology (90% of respondents’ Neurology departments) and limited experience in brain parenchyma sonography (34%), cardiac echoscopy (25%), ultrasound-guided techniques (24%), and nerve ultrasound (14%) was reported. Fifty-three percent of the participants reported to have a full-time neurosonology lab in their department and only 14% reported to have neurologists dedicated exclusively to neurosonology. Most participants (54%) reported to lack continuous learning opportunities, and 97% to need training in one or more neurosonology techniques. Main SWOT were respectively requiring expertise, shortage of time, versatility and comprehensive management of the neurological patient.</div></div><div><h3>Conclusion</h3><div>Vascular neurosonology is widely instituted in Spain, but the implementation of full-time neurosonology labs and training in non-vascular neurosonology techniques is yet scarce.</div></div>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"40 6","pages":"Pages 548-557"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the diagnostic utility of the electroencephalogram in pediatric emergencies","authors":"M.J. Abenza Abildúa ,&nbsp;T. Olmedo Menchen ,&nbsp;A. Pérez Villena ,&nbsp;S. Ruhland Paulete ,&nbsp;F.J. Navacerrada Barrero ,&nbsp;J. de Ojeda Ruíz de Luna ,&nbsp;C. Algarra Lucas ,&nbsp;G. Cordero Martín ,&nbsp;S. Martínez Ubierna ,&nbsp;C. Jimeno Montero ,&nbsp;I.J. Navarro López ,&nbsp;E. Suárez Gisbert ,&nbsp;Á. Gómez de la Riva ,&nbsp;C. Pérez López ,&nbsp;M.L. Herreros Fernández","doi":"10.1016/j.nrleng.2024.08.001","DOIUrl":"10.1016/j.nrleng.2024.08.001","url":null,"abstract":"<div><h3>Introduction</h3><div>We analyze the diagnostic utility of urgent EEG (electroencephalogram) performed in children under 16 years of age in our center.</div></div><div><h3>Material and methods</h3><div>Descriptive, retrospective, observational study of consecutive patients from 0 to 16 years of age, who underwent an urgent EEG for any reason, from January to December 2022.</div></div><div><h3>Results</h3><div>Of the 388 patients, 70 were children: 37 (52.85%) women, and 33 (47.14%) men. Average age: 6.27 ± 4.809. Of the 70 patients, 6 (8.57%) had previous epilepsy. Reasons for consultation: 17 febrile seizures, 10 first focal seizures, 10 first TCG seizures, 6 paroxysmal episodes, 6 absences, 3 myoclonus of extremities, 3 syncope, 2 SE, 2 visual alterations, 2 low level of consciousness, 2 cyanosis, 2 suspected meningitis or encephalitis, 1 choking, 1 atypical headache, 1 chorea, 1 presyncope, 1 language delay. Of the 70 patients, 47 had a normal EEG (67.14%). Of the 47 patients with a normal EEG, 10 were diagnosed with epilepsy, and 3 of them began receiving antiepileptic treatment upon discharge. None of the patients with suspected syncope or paroxysmal disorder (17 patients, 24.28%) had EEG abnormalities. Of the 17 patients with atypical febrile seizures, 3 had EEG abnormalities.</div></div><div><h3>Conclusions</h3><div>A third of the EEG records performed in the Emergency Department showed alterations, probably due to the time taken. Almost half of the patients with suspected epilepsy or EE showed EEG abnormalities, which confirmed the diagnosis in these cases and encouraged the clinician to start drug treatment. No case with a high suspicion of epilepsy was dismissed due to the normality of the EEG recording in our series. No patient diagnosed with syncope or paroxysmal disorder had EEG abnormalities. Nearly a quarter of patients with atypical febrile seizures showed EEG abnormalities. We barely register cases of status epilepticus, probably due to the degree of complexity of our center.</div></div>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"40 6","pages":"Pages 499-506"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and outcoMes of MInor stroke and high-risk traNsient ischEmic attack in NordicTus. IMMINENT study","authors":"M.E. Ramos-Araque ,&nbsp;M. Castellanos ,&nbsp;L. Naya Rios ,&nbsp;E. López-Cancio ,&nbsp;J. Molina Gil ,&nbsp;J. Marta-Moreno ,&nbsp;H. Tejada-Meza ,&nbsp;M. Temprano Fernández ,&nbsp;C. Antón González ,&nbsp;D. Vidal de Francisco ,&nbsp;J. Tejada-García ,&nbsp;J.L. Maciñeiras Montero ,&nbsp;P. Vicente Alba ,&nbsp;J.M. García-Sánchez ,&nbsp;B. Aguilera Irazabal ,&nbsp;M. Martínez-Zabaleta ,&nbsp;I.N. Diez ,&nbsp;A. Pinedo Brochado ,&nbsp;I. Azkune Calle ,&nbsp;M.M. Freijo ,&nbsp;J.F. Arenillas","doi":"10.1016/j.nrleng.2025.06.010","DOIUrl":"10.1016/j.nrleng.2025.06.010","url":null,"abstract":"<div><h3>Background</h3><div>Our primary aim was to investigate the incidence of non-cardioembolic minor acute ischemic stroke (AIS) and high-risk transient ischemic attack (TIA) and to identify predictors of stroke recurrence/death and severe bleeding. We also evaluated the rates of TIA, major vascular events, therapeutic management and predictors of poor functional outcome at 3 months in these patients.</div></div><div><h3>Methods</h3><div>We retrospectively reviewed data from all stroke patients evaluated at the emergency department of 19 hospitals belonging to the NORDICTUS stroke network between July and December 2019. Consecutive patients with non-cardioembolic minor AIS (NIHSS ≤5) and high-risk TIA (ABCD2 ≥6 or ipsilateral stenosis ≥50%) were included. We recorded clinical, neuroimaging and therapeutic variables. Follow-up was performed at 30 and 90 days. Functional prognosis was assessed with the modified Rankin scale score (mRS).</div></div><div><h3>Results</h3><div>Of 8275 patients, 1679 (20%) fulfilled IMMINENT criteria (1524 AIS/155 TIA), resulting in a global incidence of 48/100,000 inhabitants per-year. Recurrent stroke/death occurred in 73 (4.3%) patients. Extracranial ipsilateral stenosis (&gt;50%): HR 1.999 (95% CI: 1.115–3.585, <em>p</em> <!-->=<!--> <!-->0.020) and lack of hyperacute cerebral arterial assessment: HR 1.631 (95% CI: 1.009–2.636, <em>p</em> <!-->=<!--> <!-->0.046) were associated with recurrent stroke/death at 90 days. Intracranial stenosis was associated with poor prognosis (<em>p</em> <!-->=<!--> <!-->0.044). Reperfusion therapy was given to 147 (9%) and urgent double antiplatelet therapy (DAPT) to 320 (21%) patients.</div></div><div><h3>Conclusion</h3><div>Twenty percent of our stroke patients presented as non-cardioembolic high-risk TIA or minor AIS. Extracranial ipsilateral stenosis and lack of hyperacute cerebral arterial assessment were predictors of stroke recurrence/death; intracranial stenosis was associated with poor outcome. Despite current recommendations there was a low penetrance of DAPT.</div></div>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"40 6","pages":"Pages 489-498"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144766413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple sclerosis mortality trends in Spain from 1981 to 2020","authors":"L. Cayuela ,&nbsp;A. de Albóniga-Chindurza ,&nbsp;S. Gómez Enjuto ,&nbsp;J. Lapeña-Motilva ,&nbsp;S. Sainz de la Maza ,&nbsp;A. González García ,&nbsp;A. Cayuela","doi":"10.1016/j.nrleng.2025.06.006","DOIUrl":"10.1016/j.nrleng.2025.06.006","url":null,"abstract":"<div><h3>Objective</h3><div>Assess time trends in mortality from multiple sclerosis (MS) in the Spanish population (1981–2020), considering the influence of independent effects of gender, age, period, and birth cohort.</div></div><div><h3>Methods</h3><div>MS deaths and populations needed for calculations were obtained from the National Institute of Statistics. Age-standardised mortality rates (ASMR) and trend analysis were performed using joinpoint regression software. Age-period-cohort (APC) analysis was performed using the web-based statistical tool of the US National Cancer Institute to explore the underlying reason for the MS mortality.</div></div><div><h3>Results</h3><div>ASMR increased significantly in both women and men (1.7% and 1.2% respectively). The joinpoint analysis detected no trend change for women, but for men it detects a first period where rates remain stable (1981–2000; annual percentage change: −0.7%, not significant) followed by a period of significant increase (2000–2020; 2.6%, <em>P</em> <!-->&lt;<!--> <!-->0.05). For period effects, a steady increase was observed among women since the early 1990s and among men since the late 1990s. A birth cohort-related increase in mortality was detected: women born from 1916 onwards see their risk of MS mortality increase until it peaks in 1956, after which it decreases. A similar pattern is observed in men, albeit with a decade delay (from 1926 to 1966).</div></div><div><h3>Conclusion</h3><div>ASMR shows a steady increase in both sexes over the last decades, although it has been more intense in men. The decreasing birth cohort pattern for MS mortality in men born since the mid-1960s and women born since the mid-1950s is similar to APC analyses in other countries.</div></div>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"40 6","pages":"Pages 558-566"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complex regional pain syndrome and palmar fibromatosis secondary to treatment with primidone","authors":"C. Utrilla-Pérez,&nbsp;M.C. Mateos-De Pablo,&nbsp;C. Guijarro-Castro","doi":"10.1016/j.nrleng.2025.06.004","DOIUrl":"10.1016/j.nrleng.2025.06.004","url":null,"abstract":"","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"40 6","pages":"Pages 608-609"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological quality of systematic reviews on treatments for Parkinson's disease: A cross-sectional study","authors":"Y. Zhang ,&nbsp;Y. Lin ,&nbsp;C.C.W. Zhong ,&nbsp;F.F. Ho ,&nbsp;I.X.Y. Wu ,&nbsp;C. Mao ,&nbsp;X. Yang ,&nbsp;V.C.H. Chung","doi":"10.1016/j.nrleng.2025.06.008","DOIUrl":"10.1016/j.nrleng.2025.06.008","url":null,"abstract":"<div><h3>Background</h3><div>Systematic reviews (SR) of high methodological quality can provide the best evidence for clinical practice. However, the methodological quality of SRs on Parkinson's disease treatments has not been evaluated comprehensively. The study aims to assess the methodological quality of a representative sample of SRs on Parkinson's disease treatments.</div></div><div><h3>Methods</h3><div>Four databases were searched to obtain potentially eligible SRs published between January 2016 and December 2021. A pre-designed questionnaire was used to extract the bibliographical characteristics of the included SRs. The AMSTAR-2 (Assessing the Methodological Quality of Systematic Reviews) tool was used to assess the methodological quality of SRs. Factors associated with methodological quality were assessed using multivariate regression analyses.</div></div><div><h3>Results</h3><div>A total of 119 eligible SRs were included and appraised. Only one SR (0.8%) was of high overall methodological quality. Four (3.4%) and 7 (5.9%) SRs were of moderate and low overall methodological quality, respectively. Among the appraised SRs, only 3 (2.5%) applied a comprehensive literature search strategy, 11 (9.2%) provided a list of excluded studies with justifications for exclusion, and 4 (3.4%) reported the sources of funding among the original studies included in the SR. Cochrane SRs and SRs published in journals with higher impact factors had relatively higher overall methodological quality.</div></div><div><h3>Conclusions</h3><div>This study demonstrated that SRs on Parkinson's disease treatments are of low methodological quality. To enhance the quality and hence the trustworthiness of SRs, the protocols of future reviews should be designed and registered a priori, and researchers should conduct a comprehensive literature search, provide a list of excluded studies with justifications for exclusion, and report sources of funding for the included original studies.</div></div>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"40 6","pages":"Pages 507-517"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between encephalopathy and clinical outcomes of COVID-19: Findings from the Philippine CORONA Study","authors":"V.M.M. Anlacan ,&nbsp;F.G.C. Gabriel ,&nbsp;R.D.G. Jamora ,&nbsp;E.Q. Villanueva III ,&nbsp;M.C.C. Sy ,&nbsp;M.H.L. Lee Yu ,&nbsp;A.I. Espiritu","doi":"10.1016/j.nrleng.2025.06.009","DOIUrl":"10.1016/j.nrleng.2025.06.009","url":null,"abstract":"<div><h3>Introduction</h3><div>This study aimed to determine whether encephalopathy is associated with such COVID-19 outcomes as disease severity, mortality, respiratory failure, intensive care unit (ICU) admission, duration of ventilator dependence, and length of ICU and hospital stay.</div></div><div><h3>Methods</h3><div>We performed a subgroup analysis comparing outcomes in patients with and without encephalopathy, based on data from a nationwide retrospective cohort study among adult patients hospitalized with COVID-19 at 37 hospital sites in the Philippines. The patient outcomes included for analysis were disease severity, mortality, respiratory failure, ICU admission, duration of ventilator dependence, and length of ICU and hospital stay.</div></div><div><h3>Results</h3><div>Of a total of 10<!--> <!-->881 COVID-19 admissions, 622 patients had encephalopathy. The adjusted hazard ratios (aHR) for mortality among mild and severe cases were 9.26 and 1.63 times greater (<em>P</em> <!-->&lt;<!--> <!-->.001), respectively, in the encephalopathy group compared to the no-encephalopathy group. Encephalopathy was associated with increased risk of severe COVID-19 (adjusted odds ratio [aOR]: 7.95; <em>P</em> <!-->&lt;<!--> <!-->.001), respiratory failure (aHR: 5.40; <em>P</em> <!-->&lt;<!--> <!-->.001), longer hospital stays (aOR: 1.36; <em>P</em> <!-->&lt;<!--> <!-->.001), and admission to the ICU (aOR: 4.26; <em>P</em> <!-->&lt;<!--> <!-->.001). We found no sufficient evidence that encephalopathy was associated with length of ICU stay (aOR: 1.11; <em>P</em> <!-->=<!--> <!-->.522) or duration of ventilator dependence (aOR: 0.88; <em>P</em> <!-->=<!--> <!-->.428).</div></div><div><h3>Conclusions</h3><div>Encephalopathy was associated with COVID-19 severity, mortality, respiratory failure, ICU admission, and longer hospital stays.</div></div>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"40 6","pages":"Pages 567-576"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consensus document on neurosonological techniques in headaches","authors":"J. Rodríguez Vico ,&nbsp;J. Fernández Domínguez ,&nbsp;F.J. Julián Villaverde ,&nbsp;N. González García ,&nbsp;C. García-Cabo Fernández ,&nbsp;A. Jaimes Sanchez ,&nbsp;Ó. Ayo Martín ,&nbsp;J.A. Membrilla López ,&nbsp;R.G. Martínez Martín ,&nbsp;J. García Ull ,&nbsp;P. Martínez Sánchez ,&nbsp;L. Dorado Bouix ,&nbsp;R. Belvis Nieto ,&nbsp;P. Irimia","doi":"10.1016/j.nrleng.2025.06.005","DOIUrl":"10.1016/j.nrleng.2025.06.005","url":null,"abstract":"<div><h3>Introduction</h3><div>Neurosonology is a medical discipline that utilizes ultrasound techniques to study the nervous system, with its applications progressively increasing. The indications and methodology for applying these techniques in patients with headaches are not well defined, thus there is a need for a consensus guideline, based on expert opinion, to standardize their application in clinical practice.</div></div><div><h3>Development</h3><div>Experts in headaches and neurosonology, appointed by the headache study group of the Spanish Society of Neurology and the Spanish Society of Neurosonology, identified primary and secondary headaches where neurosonology has the greatest clinical application. A qualitative systematic review of the literature was conducted, based on available scientific evidence.</div></div><div><h3>Conclusions</h3><div>Cervical color duplex is considered a screening technique in patients with a high clinical suspicion of arterial dissection and may also be indicated for follow-up. Transcranial Doppler is a useful technique for evaluating the presence of vasospasm based on changes in mean flow velocity, and resistance and pulsatility indexes. Identification of the \"halo sign\" is highly specific for temporal arteritis. Measurement of the optic nerve sheath allows evaluation of the presence of intracranial hypertension. Finally, neurosonology may assist in occipital infiltration procedures or lumbar puncture and enables identification of changes in structures involved in the pathophysiology of migraine such as the periaqueductal gray matter and the raphe nuclei.</div></div>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"40 6","pages":"Pages 599-607"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The economic burden of migraine: a nationwide cost-of-illness approach from the year 2020 European Health Survey in Spain","authors":"J. Fernández-Ferro ,&nbsp;C. Ordás-Bandera ,&nbsp;J. Rejas-Gutiérrez ,&nbsp;B. Ferro-Rey ,&nbsp;S. Gómez-Lus ,&nbsp;J.M. Láinez Andrés","doi":"10.1016/j.nrleng.2025.06.002","DOIUrl":"10.1016/j.nrleng.2025.06.002","url":null,"abstract":"<div><h3>Background</h3><div>Migraine is a chronic highly disabling disease that manifests itself with recurrent episodes of headache. The objective of the study was to ascertain the cost-of-illness (COI) of migraine from the perspective of Society in Spain and to characterize its excess cost.</div></div><div><h3>Methods</h3><div>The nationwide year-2020 European-Health-Survey-in-Spain was used; 1442 persons with migraine (77.3% women, 52.5 years) and 4288 without migraine (76.7% women, 52.8 years) were abstracted by propensity score optimal matching. COI accounted healthcare resources utilization (HRU) and non-HRU (productivity loss). Costs were expressed as Per-Patient-Per-Year (PPPY) in Euros year 2020, and the excess cost was computed as the difference between persons with and without migraine.</div></div><div><h3>Results</h3><div>The PPPY cost was more than double in persons with migraine; euro5862 vs euro2981; excess cost of euro2881euro (95% CI: 2410-3353, <em>P</em> &lt; 0.001), mainly attributable to labour productivity loss; euro1928 (1532-2325, <em>P</em> &lt; 0.001) annually (66.9% of total excess cost). This excess labour cost is explained by the greater number of additional days of absenteeism, 22.35 (16.12; 28.57), and presenteeism, 31.39 (27.36; 35.41) in persons with migraine, <em>P</em> &lt; 0.001 in both cases. National Health System (NHS)-funded healthcare PPPY cost represented the 29.0% of total excess cost; euro836 (618-1055), this because higher utilization of all-type medical visits.</div></div><div><h3>Conclusion</h3><div>In Spain, persons with migraine showed a meaningful excess cost compared with persons without migraine, particularly due to labour cost component, although the economic cost to the NHS was also considerable. Given the high prevalence of migraine, its overall attributable economic impact for Spain might range between 10 394 and 14 cost 230 million Euros in year 2020.</div></div>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"40 6","pages":"Pages 533-547"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute inflammatory demyelinating polyneuropathy shortly after administration of intravitreal ranibizumab: A clinical and electrophysiological annotation","authors":"J. Berciano ,&nbsp;A. García","doi":"10.1016/j.nrleng.2025.06.007","DOIUrl":"10.1016/j.nrleng.2025.06.007","url":null,"abstract":"","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"40 6","pages":"Pages 610-611"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144766911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}