Neurologia最新文献_第9页

Endovascular treatment of vertebrobasilar ischaemic stroke in Aragon: clinical and radiological characteristics, management times, and prognosis at 3 months 阿拉贡椎基底动脉缺血性中风的血管内治疗：临床和放射学特征、治疗时间和 3 个月后的预后。

Neurologia

Pub Date : 2025-04-01 DOI: 10.1016/j.nrleng.2025.03.004

I. Saldaña-Inda , H. Tejada-Meza , B. Domínguez-Lagranja , M.R. Barrena-Caballo , A. Sancho-Saldaña , M. Serrano-Ponz , J. Marta-Moreno

Introduction

Posterior circulation stroke accounts for 15% to 20% of ischaemic strokes, but is associated with poor functional and vital prognosis in over 60% of cases. Due to its clinical and radiological peculiarities, diagnosis and management are more complex than in anterior circulation stroke. This study analyses and characterises patients with vertebrobasilar strokes treated with mechanical thrombectomy in our region.

Methods

We conducted a descriptive, retrospective analysis of patients with vertebrobasilar stroke and treated with mechanical thrombectomy at our centre, a reference centre for cerebrovascular emergencies for the region of Aragon. We recorded baseline characteristics, risk factors, signs and symptoms at onset, radiological assessment scale scores, procedure-related variables, management times, and functional prognosis at 3 months.

Results

We selected 37 patients (39.5% women; mean age [standard deviation], 68.34 [14.1] years). Cardioembolic stroke (42.1%) was the most common aetiology, followed by atherothrombosis (28.9%). The top of the basilar artery was the most common site of obstruction (55.3%). The most frequent clinical features were somnolence (76.3%), motor deficits (71.1%), and nausea (55.3%). Successful reperfusion (mTICI ≥ 2b) was achieved in 81.1% of patients. Functional outcome at 90 days was poor (mRS < 3) in 59% of patients.

Conclusions

Posterior circulation stroke is associated with high rates of morbidity and mortality. Its subacute, nonspecific clinical course prolongs management times and hinders early detection. Mechanical thrombectomy is a safe and effective procedure, although further studies are needed to establish the optimal patient profile.

后循环卒中占缺血性卒中的15%-20%，但在60%以上的病例中伴有功能不良和生命预后不良。由于其临床和影像学特点，诊断和治疗比前循环卒中更为复杂。本研究分析了我们地区椎基底动脉卒中机械取栓治疗患者的特点。方法：我们对在我们中心（阿拉贡地区脑血管急诊的参考中心）接受机械取栓治疗的椎基底动脉卒中患者进行了描述性、回顾性分析。我们记录了基线特征、危险因素、发病时的体征和症状、放射学评估量表评分、手术相关变量、治疗时间和3个月时的功能预后。结果：入选37例患者(女性39.5%；平均年龄[标准差]68.34[14.1]岁)。心脏栓塞性中风（42.1%）是最常见的病因，其次是动脉粥样硬化血栓形成（28.9%）。基底动脉顶部是最常见的阻塞部位（55.3%）。最常见的临床特征是嗜睡（76.3%）、运动障碍（71.1%）和恶心（55.3%）。81.1%的患者实现了再灌注成功（mTICI≥2b）。59%的患者90天的功能预后较差（mRS < 3）。结论：后循环卒中与高发病率和死亡率相关。它的亚急性、非特异性临床病程延长了治疗时间，阻碍了早期发现。机械取栓是一种安全有效的方法，但需要进一步的研究来确定最佳的患者概况。

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引用次数: 0

Clinical features of phantom limb pain in patients with lower limb amputation in a Spanish population 西班牙人群下肢截肢患者幻肢痛的临床特征

Neurologia

Pub Date : 2025-04-01 DOI: 10.1016/j.nrleng.2025.03.002

M. Rubiera Valdés , O. Gutiérrez Remis , A. González Jáimez , C. Manzaneque Rodríguez , V. Chiminazzo , G. Morís

Objectives

The aim of this research is to present the clinical characteristics of phantom limb pain (PLP) in patients with amputation.

Methods

A retrospective cross-sectional observational study of patients with lower limb amputation is presented. Patients between 18 and 80 years of age with unilateral or bilateral amputation between the years 2015 and 2019 were included. Demographic data, medical history, data related to the amputation, and related abnormal sensations were collected.

Results

43 patients (34 men) and 53 amputees were studied, with a mean age of 62 years, with a time elapsed since amputation of 28 months. The most frequent cause of amputation was ischemic (70%). Twenty-three (60%) patients had PLP that began 1 month after amputation with a mean intensity of 3.9 on the VAS scale, in 15 patients the PLP was daily, three patients recognised the disappearance of PLP. 91% of the patients presented non-painful sensations in relation to the phantom limb. No differences were found in the development of the PLP between the 1st and 2nd amputation. A significant association was found between the development of PLP and residual limb pain.

Conclusions

PLP is a prevalent pathology among amputee patients, therefore multidisciplinary care with an active neurologic participation is essential. Studies are needed to deepen the knowledge of the factors that favour the development of PLP in order to focus early and targeted therapies to prevent the appearance of PLP.

目的：探讨截肢患者幻肢痛（PLP）的临床特点。方法：对下肢截肢患者进行回顾性横断面观察研究。纳入了2015年至2019年期间18至80岁的单侧或双侧截肢患者。收集患者的人口学资料、病史、截肢相关资料及相关异常感觉。结果：43例患者（男性34例），53例截肢患者，平均年龄62岁，截肢时间28个月。最常见的截肢原因是缺血（70%）。23例（60%）患者在截肢后1个月开始出现PLP， VAS评分平均强度为3.9,15例患者PLP为每日，3例患者PLP消失。91%的患者表现出与幻肢有关的无痛感觉。在第一次和第二次截肢之间，PLP的发展没有差异。PLP的发生与残肢疼痛之间存在显著关联。结论：PLP在截肢患者中是一种普遍的病理，因此多学科治疗和积极的神经系统参与是必不可少的。需要进行研究以加深对有利于PLP发展的因素的了解，以便专注于早期和靶向治疗以防止PLP的出现。

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引用次数: 0

Quality of life and mental health in young strokes 青少年中风患者的生活质量和心理健康

Neurologia

Pub Date : 2025-04-01 DOI: 10.1016/j.nrleng.2025.03.003

D. Alonso Modino , L. Perestelo Pérez , F.M. Rosa González , A. Toledo Chavarri , C. Valcarcel Nazco , F.I. Montón Álvarez

Introduction

Stroke has a significant impact on mental health and health-related quality of life (HRQoL); these aspects have not been sufficiently studied in young stroke.

Objectives

To evaluate HRQoL, mental health, and the relationship between these variables and the incorporation of young adults into working life after stroke.

Material and methods

We conducted a prospective descriptive study of patients with JS between 2016 and 2017, using such questionnaires and scales as EuroQol-5D, the 36-item Short Form Health Survey, National Institutes of Health Stroke Scale (NIHSS), modified Rankin Scale (mRS), 12-item General Health Questionnaire, Hamilton Anxiety and Depression Rating Scales, and BURQOL-meter; tests were administered at 2 interviews, held 6 and 12 months after stroke.

Results

We analysed 41 patients, with a mean age of 41.8 years. At one year, the mean NIHSS score was 0.54 and mRS score was 0–2 in 95.1%. No differences were observed over time in quality of life or mental health scales. Prevalence rates for depression and anxiety at one year were 46.3% and 41.5%, respectively. Male sex and active employment were associated with better HRQoL. A total of 41.5% of patients were in work at one year after the stroke. Statistically significant associations were observed between quality of life, mental health, and incorporation into working life.

Conclusions

Young stroke affects HRQoL, and patients are at high risk of anxiety and depression, underdiagnosed and undertreated disorders that affect quality of life and the return to work, which decreases after stroke in young adults.

卒中对心理健康和健康相关生活质量（HRQoL）有显著影响；这些方面还没有在青少年中风中得到充分的研究。目的：评价脑卒中后年轻人的HRQoL、心理健康状况及其与工作生活的关系。材料与方法：采用EuroQol-5D、36项简明健康调查、美国国立卫生研究院卒中量表（NIHSS）、改良Rankin量表（mRS）、12项一般健康问卷、汉密尔顿焦虑抑郁评定量表、BURQOL-meter等问卷和量表，对2016 - 2017年JS患者进行前瞻性描述性研究；测试在中风后6个月和12个月进行两次访谈。结果：我们分析了41例患者，平均年龄41.8岁。1年时，平均NIHSS评分为0.54，mRS评分为0-2的占95.1%。随着时间的推移，在生活质量或心理健康量表上没有观察到差异。抑郁和焦虑在一年内的患病率分别为46.3%和41.5%。男性性别和积极就业与较好的HRQoL相关。共有41.5%的患者在中风后一年内仍在工作。在统计上观察到生活质量、心理健康和融入工作生活之间的显著关联。结论：青壮年脑卒中影响患者HRQoL，患者存在焦虑、抑郁、诊断和治疗不足等影响生活质量和重返工作岗位的疾病，这些疾病在青壮年脑卒中后减少。

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引用次数: 0

Knowledge about oral preventive treatments in patients with migraine: A nationwide study 关于偏头痛患者口服预防治疗的知识：一项全国性研究。

Neurologia

Pub Date : 2025-04-01 DOI: 10.1016/j.nrleng.2025.03.006

A. López-Bravo , S. Quintas , A. Mínguez-Olaondo , A. Alpuente , C. Nieves-Castellanos , M. Pilar Navarro-Pérez , S. Pérez-Pereda , A. Layos Romero , C. Calle de Miguel , D. García-Azorín , M. Torres-Ferrús , S. Santos-Lasaosa

Background

Patients’ knowledge about their medications is key to guarantee therapeutic compliance in chronic diseases.

Aims of the study

To determine patients’ knowledge of oral preventive treatment (OPT) in migraine.

Methods

This is a cross-sectional study evaluating knowledge of medication with a validated questionnaire that assessed: therapeutic objective, process of use, safety and conservation.

Results

198 patients were included. Mean age was 45.4 ± 11.5 years-old and 92.4% were women. A 61.1% of migraine patients did not know the medication they used, 55.1% showed insufficient knowledge and 6.1% had no knowledge. The most known dimension was conservation (80.3%) and the most unknown dimension of was safety (33.7%). In this regard, 82.3% considered that they should not take precautions when taking the treatment, 80.3% stated that it had no contraindications and 82.8% were unaware of possible interactions with other medications. Worse knowledge about OPT was associated with longer time since migraine onset (p = .049), higher scores on the Hospital Anxiety and Depression Scale (p = .021), less qualified jobs (p = .045), use of monotherapy (p = .001) and longer periods since OPT initiation (p = .013).

Conclusions

The majority of migraine patients did not adequately know their preventive treatment, despite identifying some of the items related to their medication. The present study shows that knowledge of patients about their preventive treatment should be evaluated in clinical practice and could help migraine patients in the correct use of OPT.

背景：患者对药物的了解是保证慢性疾病治疗依从性的关键。研究目的：了解患者对偏头痛口服预防治疗（OPT）的认知。方法：这是一项横断面研究，通过有效的问卷评估药物知识，评估：治疗目的，使用过程，安全性和保存。结果：纳入198例患者。平均年龄45.4±11.5岁，92.4%为女性。61.1%的偏头痛患者不知道自己使用的药物，55.1%的患者不知道自己使用的药物，6.1%的患者不知道自己使用的药物。已知的维度是“保守”（80.3%），未知的维度是“安全”（33.7%）。在这方面，82.3%的人认为不需要采取预防措施，80.3%的人表示没有禁忌症，82.8%的人不知道可能与其他药物相互作用。对OPT的了解越少，偏头痛发作时间越长（p = 0.049），医院焦虑和抑郁量表得分越高（p = 0.021），工作质量越差（p = 0.045），使用单一疗法（p = 0.001）和开始OPT后时间越长（p = 0.013）。结论：大多数偏头痛患者不充分了解他们的预防治疗，尽管确定了一些与他们的药物相关的项目。本研究表明，应在临床实践中评估患者对预防治疗的了解，并有助于偏头痛患者正确使用OPT。

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引用次数: 0

Lingual dystonia: response to botulinum toxin treatment 舌肌张力障碍：对肉毒杆菌毒素治疗的反应

Neurologia

Pub Date : 2025-04-01 DOI: 10.1016/j.nrleng.2025.03.005

A. Fernández Revuelta, E. López Valdés, R. García-Ramos

引用次数: 0

Reliable change indices for 16 neuropsychological tests at six different time points 6个不同时间点16项神经心理测试的可靠变化指标

Neurologia

Pub Date : 2025-04-01 DOI: 10.1016/j.nrleng.2025.03.007

O. Sáez-Atxukarro , J. Peña , R. del Pino , N. Ibarretxe-Bilbao , N. Ojeda

Introduction

Neuropsychological assessment often involves repeated testing in order to assess a cognitive change or conduct a longitudinal follow-up study of a patient. To assess whether the change between assessments is relevant or not, longitudinal reference data are needed. The aim of this study is to provide reference data to enable interpretation of score changes between assessments for 16 commonly used tests, at six different time intervals between successive assessments, using five reliable change indices.

Methods

The study is part of the Normacog project, in which 388 healthy participants recruited in Spain (aged 18–84 years) were assessed on two occasions. A baseline assessment was carried out, and then followed up at 1 month (n = 67), 3 months (n = 64), 6 months (n = 59), 9 months (n = 60), 12 months (n = 68), or 24 months (n = 70). Longitudinal data were analyzed, and reliable change indices were calculated.

Results

A significant improvement was observed between assessment scores for all time points, especially in memory-related variables. Reference data are provided using the following indices: discrepancy scores expressed in percentiles, standard deviation index (SDI), reliable change index (RCI), RCI + practice effect (RCI + PE), and standardized regression-based formulae.

Conclusions

This study provides data to analyze whether or not a cognitive change can be considered reliable. The results support the use of these reliable change indices to avoid biases related to successive assessments. This study will lay the foundations for the implementation of these tools in clinical practice, and will be a reference for the creation of reliable change indices.

神经心理学评估通常包括重复测试，以评估认知变化或对患者进行纵向随访研究。为了评估评估之间的变化是否相关，需要纵向参考数据。本研究的目的是提供参考数据，以解释16个常用测试在连续评估之间的六个不同时间间隔，使用五个可靠的变化指数之间的评分变化。该研究是Normacog项目的一部分，该项目在西班牙招募了388名健康参与者（18-84岁），分两次进行评估。进行基线评估，然后随访1个月（n = 67）、3个月（n = 64）、6个月（n = 59）、9个月（n = 60）、12个月（n = 68）或24个月（n = 70）。对纵向数据进行分析，计算出可靠的变化指数。结果两组在各时间点的评分均有显著改善，尤其是在记忆相关变量方面。参考数据采用以下指标：以百分位数表示的差异评分、标准差指数（SDI）、可靠变化指数（RCI）、RCI +实践效果（RCI + PE）和基于标准化回归的公式。结论本研究为分析认知改变是否可靠提供了数据。结果支持使用这些可靠的变化指数来避免与连续评估相关的偏差。本研究将为这些工具在临床实践中的应用奠定基础，并为建立可靠的变化指标提供参考。

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引用次数: 0

Molecular dynamics of amyloid-β transport in Alzheimer's disease: Exploring therapeutic plasma exchange with albumin replacement – Current insights and future perspectives 阿尔茨海默病中淀粉样蛋白-β转运的分子动力学：探索白蛋白替代治疗性血浆交换-目前的见解和未来的观点

Neurologia

Pub Date : 2025-04-01 DOI: 10.1016/j.nrleng.2025.03.008

R. Mondal , S. Deb , G. Shome , V. Sarkar , D. Lahiri , S.S. Datta , J. Benito-León

Introduction

The complex process of amyloid-β (Aβ) transportation across the blood–brain and blood–cerebrospinal fluid barriers is crucial for preventing Aβ accumulation, which linked to dementia and neurodegeneration. This review explores therapeutic plasma exchange with albumin replacement in Alzheimer's disease, based on the dynamics of amyloid-β between the brain, plasma, and cerebrospinal fluid.

Methodology

A comprehensive literature review was conducted using PubMed/Medline, Cochrane Library, and open databases (bioRxiv, MedRixv, preprint.org) up to April 30, 2023. The first search utilized the following MeSH terms and keywords: ‘Plasma Exchange’, ‘Plasmapheresis’, ‘Therapeutic plasma exchange’, ‘Apheresis’, ‘Aβ’, ‘p-tau’, ‘Total-tau’, ‘Alzheimer's disease’, ‘Cognitive dysfunction’, ‘neurodegenerative diseases’, ‘centrifugation’, ‘membranous’, and ‘filtration’ in the Title/Abstract, yielding 146 results. A second search with the keywords: ‘Albumin’, ‘Aβ’, ‘BBB’, ‘Alzheimer's dementia’, and ‘Nerve degeneration’ resulted in 125 additional articles for analysis. Finally, a third search using keywords: ‘Albumin structural domains’, ‘Albumin-Aβ interactions’, ‘Albumin-endothelial interactions’, and ‘Post-Translational Modification’ produced 193 results for further review.

Results/Discussion

Therapeutic plasma exchange shows potential as a disease-modifying therapy for dementia, specifically for Alzheimer's disease. Additionally, the promising role of albumin supplementation in cognitive improvement has attracted attention. However, clinical evidence supporting therapeutic plasma exchange for dementia remains limited, necessitating further research and development to mitigate potential adverse effects. A deeper understanding of the molecular dynamics of Aβ transportation and the mechanisms of therapeutic plasma exchange is essential. A critical evaluation of existing evidence highlights the importance of balancing potential benefits with associated risks, which will guide the development and application of these treatments in neurodegenerative diseases.

淀粉样蛋白-β (Aβ)通过血脑和血脑脊液屏障运输的复杂过程对于防止与痴呆和神经变性相关的Aβ积累至关重要。本文基于脑、血浆和脑脊液之间淀粉样蛋白-β的动态变化，探讨了治疗性血浆置换与白蛋白替代治疗阿尔茨海默病。方法截至2023年4月30日，使用PubMed/Medline、Cochrane Library和开放数据库（bioRxiv、MedRixv、preprint.org）进行综合文献综述。第一次搜索利用以下MeSH术语和关键词：“血浆置换”、“血浆置换”、“治疗性血浆置换”、“单胞置换”、“Aβ”、“p-tau”、“Total-tau”、“阿尔茨海默病”、“认知功能障碍”、“神经退行性疾病”、“离心”、“膜性”和“过滤”，在标题/摘要中产生146个结果。第二次搜索关键词：“白蛋白”、“Aβ”、“血脑卒中”、“阿尔茨海默氏痴呆症”和“神经变性”，结果是125篇额外的文章用于分析。最后，使用关键词“白蛋白结构域”、“白蛋白- β相互作用”、“白蛋白-内皮相互作用”和“翻译后修饰”进行第三次搜索，产生193个结果供进一步审查。结果/讨论治疗性血浆交换显示出作为痴呆症，特别是阿尔茨海默病的疾病改善疗法的潜力。此外，补充白蛋白在改善认知方面的有希望的作用也引起了人们的注意。然而，支持血浆置换治疗痴呆的临床证据仍然有限，需要进一步研究和开发以减轻潜在的不良影响。更深入地了解Aβ转运的分子动力学和治疗血浆交换的机制是必不可少的。对现有证据的批判性评估强调了平衡潜在益处与相关风险的重要性，这将指导这些治疗在神经退行性疾病中的发展和应用。

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引用次数: 0

Clinical practice guidelines for the diagnosis and management of Charcot-Marie-Tooth disease Charcot-Marie-Tooth 疾病诊断和管理临床实践指南。

Neurologia

Pub Date : 2025-04-01 DOI: 10.1016/j.nrleng.2024.02.008

R. Sivera Mascaró , T. García Sobrino , A. Horga Hernández , A.L. Pelayo Negro , A. Alonso Jiménez , A. Antelo Pose , M.D. Calabria Gallego , C. Casasnovas , C.A. Cemillán Fernández , J. Esteban Pérez , M. Fenollar Cortés , M. Frasquet Carrera , M.P. Gallano Petit , A. Giménez Muñoz , G. Gutiérrez Gutiérrez , A. Gutiérrez Martínez , R. Juntas Morales , N.L. Ciano-Petersen , P.L. Martínez Ulloa , S. Mederer Hengstl , T. Sevilla Mantecón

Introduction

Charcot-Marie-Tooth disease (CMT) is classified according to neurophysiological and histological findings, the inheritance pattern, and the underlying genetic defect. The objective of these guidelines is to offer recommendations for the diagnosis, prognosis, follow-up, and treatment of this disease in Spain.

Material and methods

These consensus guidelines were developed through collaboration by a multidisciplinary panel encompassing a broad group of experts on the subject, including neurologists, paediatric neurologists, geneticists, physiatrists, and orthopaedic surgeons.

Recommendations

The diagnosis of CMT is clinical, with patients usually presenting a common or classical phenotype. Clinical assessment should be followed by an appropriate neurophysiological study; specific recommendations are established for the parameters that should be included. Genetic diagnosis should be approached sequentially; once PMP22 duplication has been ruled out, if appropriate, a next-generation sequencing study should be considered, taking into account the limitations of the available techniques. To date, no pharmacological disease-modifying treatment is available, but symptomatic management, guided by a multidiciplinary team, is important, as is proper rehabilitation and orthopaedic management. The latter should be initiated early to identify and improve the patient’s functional deficits, and should include individualised exercise guidelines, orthotic adaptation, and assessment of conservative surgeries such as tendon transfer. The follow-up of patients with CMT is exclusively clinical, and ancillary testing is not necessary in routine clinical practice.

简介Charcot-Marie-Tooth (CMT) 病是根据神经生理学和组织学检查结果、遗传模式和潜在基因缺陷进行分类的。近年来，随着新一代测序技术的出现，遗传复杂性呈指数级增长，扩大了对疾病路径的了解，并对临床管理产生了影响。本指南旨在为西班牙该疾病的诊断、预后、监测和治疗提供建议：本共识指南由一个多学科小组制定，小组成员包括神经科医生、神经儿科医生、遗传学家、康复师和矫形外科医生等众多专业人士：诊断以临床特征为基础，通常表现为共同的表型。随后应进行适当的神经生理学研究，以便进行正确的分类，并就应包括的参数提出具体建议。基因诊断必须按顺序进行，一旦排除了 PMP22 复制，就应考虑进行下一代测序，同时考虑到现有技术的局限性。迄今为止，还没有药物治疗方法可以改变疾病的进程，但对症治疗以及康复和矫形方面的考虑都很重要。后者应及早开始，以识别并改善患者的功能障碍，包括个体化的锻炼指南、矫形器适应以及对肌腱转位等保守手术的评估。CMT 患者的随访完全是临床随访，在常规临床实践中无需进行辅助检查。

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引用次数: 0

Focusing on post-COVID syndrome fatigue 关注covid后综合症疲劳。

Neurologia

Pub Date : 2025-03-01 DOI: 10.1016/j.nrleng.2025.02.002

M. Gómez-Eguílaz , S. López-Alava , J.L. Ramón-Trapero , F. Castillo-Álvarez , N. Gómez Loizaga , C. García-Penco , N. Boukichou-Abdelkader , L. Pérez-Martínez

Introduction

More than 100 million people worldwide have been infected by SARS-CoV-2 virus, the virus responsible for the acute disease COVID-19. Multiple studies have shown how various symptoms in these patients can persist for several months after resolution of the acute process, a phenomenon known as post-COVID syndrome. Neurological symptoms are varied, but the great majority of patients present fatigue.

Objective

To analyse post-COVID fatigue.

Methods

We present a prospective, single-centre, case-control study comparing patients with fatigue in the context of post-COVID syndrome with patients with history of COVID-19 but without post-COVID fatigue. Data were recorded at baseline (April 2021) and at 6 months. Data were recorded on clinical variables, fatigue questionnaires, sleep disorders, depression, anxiety, cognitive impairment, and quality of life. Basic laboratory analysis was performed with blood samples collected at the 2 visits. In addition, a substudy of proinflammatory (IL-6, IL-1β, TNF-α) and anti-inflammatory (IL-10) cytokines was performed.

Results

Fatigue as measured by the Chalder Fatigue Scale was mixed (physical and psychological) and of moderate intensity. At 6 months, physical fatigue improved, but psychological fatigue did not. Significant differences were found in sleepiness, cognitive impairment, anxiety, and quality of life. Significant alterations were observed in TNF-α levels, but not in the remaining cytokines.

Conclusions

Patients with fatigue presented a poorer quality of life, with an improvement being observed at 6 months, which suggests a course that may be self-limiting; however, this will have to be confirmed with longer studies.

导语：全球有超过1亿人感染了SARS-CoV-2病毒，这种病毒导致了一种名为COVID-19的急性疾病。多项研究表明，这些患者的各种症状在急性过程（称为后covid综合征）消退后可以持续数月。神经科临床表现多样，但常表现为疲劳。目的：分析新冠肺炎后疲劳症状。方法：我们进行了一项单中心、前瞻性、病例对照研究，比较了COVID-19后综合征背景下的疲劳患者与已通过COVID-19但未出现COVID-19后疲劳的患者。基线记录（2021年4月）和6个月时的对照记录。记录临床变量、疲劳问卷、睡眠障碍、抑郁、焦虑、认知障碍和生活质量。收集了2次访问的基本分析。此外，还进行了炎症（IL-6, IL-1β, TNF-α）和抗炎（IL-10）细胞因子的亚研究。结果：Chadler测量的患者疲劳程度为中度和混合强度（生理和心理）。6个月时，身体疲劳有所改善，但心理疲劳没有。在嗜睡、认知衰退、焦虑和生活质量方面发现了显著差异。TNF-α值明显改变，但其余细胞因子无明显变化。结论：疲劳患者的生活质量较差，在6个月时观察到控制的改善，这表明一个过程可能是自限性的，但这还需要更长的研究来证实。

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引用次数: 0

Opsoclonus-myoclonus syndrome and prostate cancer. An entity to be aware of 肌阵挛综合征与前列腺癌。一个值得注意的实体。

Neurologia

Pub Date : 2025-03-01 DOI: 10.1016/j.nrleng.2024.02.004

C. Guijarro-Castro , L. Estallo-Guijarro

引用次数: 0