Sulfur dioxide (SO2) and its derivatives (SO32- and HSO3-), are important active sulfur species that play significant roles in physiological processes. Fluorescence probe imaging technology, due to its high temporal and spatial resolution, real-time non-invasive and non-destructive detection, has emerged as a valuable tool for studying SO2 in biological systems. In this study, we presented a colorimetric fluorescent probe for the detection of HSO3-. The structure of probe TPN-BP consists of a triphenylamine group and a benzopyrylium group that are connected by a vinyl double bond. The benzopyrylium group in probe TPN-BP, which carries a positive charge, serves two important functions: enhancing water solubility, allowing for its effective use in fully aqueous environments, and acting as a fluorescence quencher for the triphenylamine group. Upon interaction with HSO3-, probe TPN-BP exhibited significantly increase in fluorescence at 480 nm, causing the solution to change from blue to colorless. Spectral experiments showed that probe TPN-BP showed quick response time (10 s), high sensitivity (12.7 nM), and excellent selectivity towards HSO3-. It is worth noting that probe TPN-BP has been successfully used for fluorescence imaging and detection of HSO3- in plants and zebrafish. The results of this study indicated that probe TPN-BP can be used as a promising tool for the research and monitoring of SO2 in living organisms.
{"title":"A novel colorimetric fluorescent probe for sensing bisulfite detection in plant and zebrafish.","authors":"Qianqian Zhang, Xiaohong Tang, Yanjin Wang, Ajuan Song, Xiaopeng Yang, Dan Yin, Zezhi Zhang","doi":"10.1016/j.saa.2023.123559","DOIUrl":"10.1016/j.saa.2023.123559","url":null,"abstract":"<p><p>Sulfur dioxide (SO<sub>2</sub>) and its derivatives (SO<sub>3</sub><sup>2-</sup> and HSO<sub>3</sub><sup>-</sup>), are important active sulfur species that play significant roles in physiological processes. Fluorescence probe imaging technology, due to its high temporal and spatial resolution, real-time non-invasive and non-destructive detection, has emerged as a valuable tool for studying SO<sub>2</sub> in biological systems. In this study, we presented a colorimetric fluorescent probe for the detection of HSO<sub>3</sub><sup>-</sup>. The structure of probe TPN-BP consists of a triphenylamine group and a benzopyrylium group that are connected by a vinyl double bond. The benzopyrylium group in probe TPN-BP, which carries a positive charge, serves two important functions: enhancing water solubility, allowing for its effective use in fully aqueous environments, and acting as a fluorescence quencher for the triphenylamine group. Upon interaction with HSO<sub>3</sub><sup>-</sup>, probe TPN-BP exhibited significantly increase in fluorescence at 480 nm, causing the solution to change from blue to colorless. Spectral experiments showed that probe TPN-BP showed quick response time (10 s), high sensitivity (12.7 nM), and excellent selectivity towards HSO<sub>3</sub><sup>-</sup>. It is worth noting that probe TPN-BP has been successfully used for fluorescence imaging and detection of HSO<sub>3</sub><sup>-</sup> in plants and zebrafish. The results of this study indicated that probe TPN-BP can be used as a promising tool for the research and monitoring of SO<sub>2</sub> in living organisms.</p>","PeriodicalId":94213,"journal":{"name":"Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49695602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The optical excitation effects offer an opportunity to gain insights into the structure and the function of K+ channel, contributing to the prediction of possible targets for drug design and precision therapy. Although there has been increasing research attention on the modulation of ion permeation in K+ channel by terahertz electromagnetic (THz-EM) stimuli, little exploration has been conducted regarding the dependence of ion permeation on frequencies. By using two-dimensional (2D) infrared excitation spectrum calculation for the K+ channel, we have discovered that the frequency of 53.60 THz serves as an optimal excitation modulation mode. This mode leads to an almost twofold enhancement in the rate of K+ ion permeation and a tenfold increase in selectivity efficiency. These improvements can be attributed to the coupling mode matching of the excited properties of CO groups in the K+ channel. Our findings propose a promising application of terahertz technology to improve the performance of ion channels, nanomembrane sieves, nanodevices, as well as neural therapy.
{"title":"Enhancement of K<sup>+</sup> channel permeation by selective terahertz excitation.","authors":"Kaijie Wu, Yong He, Kun Chen, Mengda Cui, Zhikai Yang, Yifang Yuan, Yuchen Tian, Wenyu Peng","doi":"10.1016/j.saa.2023.123538","DOIUrl":"10.1016/j.saa.2023.123538","url":null,"abstract":"<p><p>The optical excitation effects offer an opportunity to gain insights into the structure and the function of K<sup>+</sup> channel, contributing to the prediction of possible targets for drug design and precision therapy. Although there has been increasing research attention on the modulation of ion permeation in K+ channel by terahertz electromagnetic (THz-EM) stimuli, little exploration has been conducted regarding the dependence of ion permeation on frequencies. By using two-dimensional (2D) infrared excitation spectrum calculation for the K<sup>+</sup> channel, we have discovered that the frequency of 53.60 THz serves as an optimal excitation modulation mode. This mode leads to an almost twofold enhancement in the rate of K<sup>+</sup> ion permeation and a tenfold increase in selectivity efficiency. These improvements can be attributed to the coupling mode matching of the excited properties of CO groups in the K<sup>+</sup> channel. Our findings propose a promising application of terahertz technology to improve the performance of ion channels, nanomembrane sieves, nanodevices, as well as neural therapy.</p>","PeriodicalId":94213,"journal":{"name":"Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49695606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-15Epub Date: 2023-10-19DOI: 10.1016/j.saa.2023.123565
Tiantian Wan, Zulei Zhang, Hailong Wang, Yiwen Yang, Hongmei Wang, Jian Zhang, Yanbo Zeng, Lei Li
Ascorbic acid (AA) plays an important role in many life processes. The chronic nutritional deficiency of AA will lead to the symptoms of scurvy. Therefore, the sensitive quantitative detection of AA is most important in the pharmaceutical analysis, food industry and diagnostic application. In this study, a dual-functional magnetic metal-organic frameworks (Fe3O4@SiO2@UiO-PBA) nanoparticles was synthesized by modifying phenylboronic acid to the surface of magnetic UiO-66-NH2 via postsynthetic modification for selectively and sensitively florescent detection of AA. Due to the abundant amino groups and grafted phenylboronic acid, the proposed nanoparticles have the dual properties of hydrophilicity and boronate affinity. Under optimum conditions, the obtained Fe3O4@SiO2@UiO-PBA nanoparticles can detect AA within 30 s, and has a good linear relationship with the concentration of AA in the range of 5.0-60 μM with a detection limit of 2.5 μM (S/N = 3). In addition, the prepared Fe3O4@SiO2@UiO-PBA nanoparticles showed excellent selectivity and great potential application in the highly efficient determination of trace AA in vitamin C tablets. These results indicated that a convenient method was proposed to develop fluorescent probes for rapid and sensitive detection of trace AA in real samples.
{"title":"Highly efficient determination of trace ascorbic acid in vitamin C tablets by boronate affinity-modified magnetic metal-organic frameworks.","authors":"Tiantian Wan, Zulei Zhang, Hailong Wang, Yiwen Yang, Hongmei Wang, Jian Zhang, Yanbo Zeng, Lei Li","doi":"10.1016/j.saa.2023.123565","DOIUrl":"10.1016/j.saa.2023.123565","url":null,"abstract":"<p><p>Ascorbic acid (AA) plays an important role in many life processes. The chronic nutritional deficiency of AA will lead to the symptoms of scurvy. Therefore, the sensitive quantitative detection of AA is most important in the pharmaceutical analysis, food industry and diagnostic application. In this study, a dual-functional magnetic metal-organic frameworks (Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>@UiO-PBA) nanoparticles was synthesized by modifying phenylboronic acid to the surface of magnetic UiO-66-NH<sub>2</sub> via postsynthetic modification for selectively and sensitively florescent detection of AA. Due to the abundant amino groups and grafted phenylboronic acid, the proposed nanoparticles have the dual properties of hydrophilicity and boronate affinity. Under optimum conditions, the obtained Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>@UiO-PBA nanoparticles can detect AA within 30 s, and has a good linear relationship with the concentration of AA in the range of 5.0-60 μM with a detection limit of 2.5 μM (S/N = 3). In addition, the prepared Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>@UiO-PBA nanoparticles showed excellent selectivity and great potential application in the highly efficient determination of trace AA in vitamin C tablets. These results indicated that a convenient method was proposed to develop fluorescent probes for rapid and sensitive detection of trace AA in real samples.</p>","PeriodicalId":94213,"journal":{"name":"Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49695608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Two novel click derived sensory systems for different derivatives connected via a triazole linkage have been developed as a component of a chemosensor with sensitive towards Fe3+ ions. The 1-octyl-4-carboxyl-1,2,3-triazole (TR1) system demonstrated sensitivity to calcium ion. The 1,3-bis(4-hydroxycarbamoyl-1,2,3-triazol-1-yl)xylylene (TR2) system was shown to possess a preferential detection capability as a colorimetric probe for Fe3+ ions by exhibiting an obvious pH-dependent color change from colorless to pink. Complexation of the ligands with Fe3+ ions was studied. The 1:1 stoichiometry and bonding sites of TR1-Fe3+, and TR2-Fe3+ complexes were elucidated by analyzing the Job plot. The association constants of 5.35 × 105 M1 for TR1- Fe3+ and 3.58 × 104 M1 for TR2-Fe3+ and detection limits 1.68 × 10-8 and 2.52 × 10-7 were determined from standard deviation and linear fittings.
{"title":"New substituted 1,2,3-triazoles for ratiometric recognition to Fe<sup>3+</sup> ions.","authors":"Natalia Selivanova, Marina Shulaeva, Vyacheslav Semenov, Yuriy Galyametdinov","doi":"10.1016/j.saa.2023.123558","DOIUrl":"10.1016/j.saa.2023.123558","url":null,"abstract":"<p><p>Two novel click derived sensory systems for different derivatives connected via a triazole linkage have been developed as a component of a chemosensor with sensitive towards Fe<sup>3+</sup> ions. The 1-octyl-4-carboxyl-1,2,3-triazole (TR1) system demonstrated sensitivity to calcium ion. The 1,3-bis(4-hydroxycarbamoyl-1,2,3-triazol-1-yl)xylylene (TR2) system was shown to possess a preferential detection capability as a colorimetric probe for Fe<sup>3+</sup> ions by exhibiting an obvious pH-dependent color change from colorless to pink. Complexation of the ligands with Fe<sup>3+</sup> ions was studied. The 1:1 stoichiometry and bonding sites of TR1<sub>-</sub>Fe<sup>3+</sup>, and TR2<sub>-</sub>Fe<sup>3+</sup> complexes were elucidated by analyzing the Job plot. The association constants of 5.35 × 10<sup>5</sup> M<sup>1</sup> for TR1<sub>-</sub> Fe<sup>3+</sup> and 3.58 × 10<sup>4</sup> M<sup>1</sup> for TR2<sub>-</sub>Fe<sup>3+</sup> and detection limits 1.68 × 10<sup>-8</sup> and 2.52 × 10<sup>-7</sup> were determined from standard deviation and linear fittings.</p>","PeriodicalId":94213,"journal":{"name":"Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49695609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-15Epub Date: 2023-10-18DOI: 10.1016/j.saa.2023.123555
Seonmin Park, So Yeon Bong, Shilpa Sharma, Narinder Singh, Yea-In Park, Junsoo Park, Doo Ok Jang
A benzimidazole-based probe, BIPMA (2-(1H-benzo[d]imidazol-2-yl)-N-(pyridin-2-ylmethyl)aniline), was designed and synthesized to detect Cu2+ ions. BIPMA exhibited a fluorescent "turn-on" mechanism when bound to Cu2+ ions in an acetonitrile/water mixture (5:5, v/v, HEPES 10 mM, pH 7.4) owing to the synergistic effect of the chelation-enhanced fluorescence and internal charge-transfer mechanisms. Moreover, the BIPMA probe effectively detected nanomolar-range concentrations (0-400 nM) of Cu2+ ions in an aqueous system with a detection limit of 4.80 nM; this value is significantly lower than that set by the U.S. Environmental Protection Agency (≈20 μM). Additionally, BIPMA showed an ultrafast response to Cu2+ ions, with a maximum intensity achieved 25 s after adding Cu2+. Furthermore, BIPMA detected Cu2+ ions in solutions with a pH range of 5-11, without being influenced by pH, underscoring its applicability under various physiological conditions. Density functional theory studies revealed that internal charge transfer was responsible for emission. Finally, BIPMA effectively detected Cu2+ ions in real water samples and living cells.
{"title":"Simple turn-on fluorescent chemosensor for ultrafast and highly selective trace-level detection of Cu<sup>2+</sup> ions in aqueous solutions.","authors":"Seonmin Park, So Yeon Bong, Shilpa Sharma, Narinder Singh, Yea-In Park, Junsoo Park, Doo Ok Jang","doi":"10.1016/j.saa.2023.123555","DOIUrl":"10.1016/j.saa.2023.123555","url":null,"abstract":"<p><p>A benzimidazole-based probe, BIPMA (2-(1H-benzo[d]imidazol-2-yl)-N-(pyridin-2-ylmethyl)aniline), was designed and synthesized to detect Cu<sup>2+</sup> ions. BIPMA exhibited a fluorescent \"turn-on\" mechanism when bound to Cu<sup>2+</sup> ions in an acetonitrile/water mixture (5:5, v/v, HEPES 10 mM, pH 7.4) owing to the synergistic effect of the chelation-enhanced fluorescence and internal charge-transfer mechanisms. Moreover, the BIPMA probe effectively detected nanomolar-range concentrations (0-400 nM) of Cu<sup>2+</sup> ions in an aqueous system with a detection limit of 4.80 nM; this value is significantly lower than that set by the U.S. Environmental Protection Agency (≈20 μM). Additionally, BIPMA showed an ultrafast response to Cu<sup>2+</sup> ions, with a maximum intensity achieved 25 s after adding Cu<sup>2+</sup>. Furthermore, BIPMA detected Cu<sup>2+</sup> ions in solutions with a pH range of 5-11, without being influenced by pH, underscoring its applicability under various physiological conditions. Density functional theory studies revealed that internal charge transfer was responsible for emission. Finally, BIPMA effectively detected Cu<sup>2+</sup> ions in real water samples and living cells.</p>","PeriodicalId":94213,"journal":{"name":"Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49695612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-15Epub Date: 2023-10-17DOI: 10.1016/j.saa.2023.123556
Amira H Kamal, Sherin F Hammad, Mohamed M Salim, Mahmoud M Elkhodary, Aya A Marie
Four spectrophotometric approaches had been established and optimized for the simultaneous estimation of two anti-diabetic drugs; linagliptin (LIN) and empagliflozin (EMP) in their bulk and tablet dosage form. LIN concentration could be first determined from the zero order spectra at its λmax (293 nm) without interference from EMP as at this wavelength EMP showed zero absorbance. The LIN and EMP zero order absorption spectra displayed considerable overlap which hindered the direct determination of EMP. Thus, four indirect spectrophotometric approaches were established and optimized for the determination and quantification of EMP concentrations in presence of LIN. Method (I) was ratio difference method (RD) which depended on the determination of difference amplitudes in the ratio spectra (ΔP) at 236 nm and 227 nm; ΔP(236-227) was directly proportional to EMP concentration. Method (II) was ratio derivative method (1DD) based on the measuring of the amplitude of first derivative of ratio spectra at 243 nm which was directly proportional to EMP concentration. For determination of EMP concentration using both method (I) and (II); LIN 7 µg/mL was used as the divisor. Method (III) was area under curve method (AUC) which depended on the measurement of area confined between 220 and 230 nm and 273-290 nm. Method (IV) was dual wavelength method (DWL) which based on measurement of absorbance difference (ΔA) in zero order spectra between 239.8 and 282.6 nm which was directly proportional to EMP concentration. The four developed methods were optimized and entirely validated regarding to ICH guidelines. The proposed spectrophotometric approaches were used for the quantification of LIN and EMP simultaneously in their tablet dosage form. F-test and t-test were applied for statistical comparison between the results obtained by the proposed approaches and that obtained by the reported method. There was no significant difference concerning to precision and accuracy.
{"title":"Simultaneous estimation of two anti-diabetic drugs; Linagliptin and empagliflozin in their tablet by chemometric spectrophotometry.","authors":"Amira H Kamal, Sherin F Hammad, Mohamed M Salim, Mahmoud M Elkhodary, Aya A Marie","doi":"10.1016/j.saa.2023.123556","DOIUrl":"10.1016/j.saa.2023.123556","url":null,"abstract":"<p><p>Four spectrophotometric approaches had been established and optimized for the simultaneous estimation of two anti-diabetic drugs; linagliptin (LIN) and empagliflozin (EMP) in their bulk and tablet dosage form. LIN concentration could be first determined from the zero order spectra at its λ<sub>max</sub> (293 nm) without interference from EMP as at this wavelength EMP showed zero absorbance. The LIN and EMP zero order absorption spectra displayed considerable overlap which hindered the direct determination of EMP. Thus, four indirect spectrophotometric approaches were established and optimized for the determination and quantification of EMP concentrations in presence of LIN. Method (I) was ratio difference method (RD) which depended on the determination of difference amplitudes in the ratio spectra (ΔP) at 236 nm and 227 nm; ΔP<sub>(236-227)</sub> was directly proportional to EMP concentration. Method (II) was ratio derivative method (<sup>1</sup>DD) based on the measuring of the amplitude of first derivative of ratio spectra at 243 nm which was directly proportional to EMP concentration. For determination of EMP concentration using both method (I) and (II); LIN 7 µg/mL was used as the divisor. Method (III) was area under curve method (AUC) which depended on the measurement of area confined between 220 and 230 nm and 273-290 nm. Method (IV) was dual wavelength method (DWL) which based on measurement of absorbance difference (ΔA) in zero order spectra between 239.8 and 282.6 nm which was directly proportional to EMP concentration. The four developed methods were optimized and entirely validated regarding to ICH guidelines. The proposed spectrophotometric approaches were used for the quantification of LIN and EMP simultaneously in their tablet dosage form. F-test and t-test were applied for statistical comparison between the results obtained by the proposed approaches and that obtained by the reported method. There was no significant difference concerning to precision and accuracy.</p>","PeriodicalId":94213,"journal":{"name":"Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49695613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-15Epub Date: 2023-10-05DOI: 10.1016/j.saa.2023.123485
Chiara Sepali, Piero Lafiosca, Sara Gómez, Tommaso Giovannini, Chiara Cappelli
Raman and Raman Optical Activity (ROA) signals are amply affected by solvent effects, especially in the presence of strongly solute-solvent interactions such as Hydrogen Bonding (HB). In this work, we extend the fully atomistic polarizable Quantum Mechanics/Molecular Mechanics approach, based on the Fluctuating Charges and Fluctuating Dipoles force field to the calculation of Raman and ROA spectra. Such an approach is able to accurately describe specific HB interactions, by also accounting for anisotropic contributions due to the inclusion of fluctuating dipoles. To highlight the potentiality of the novel approach, Raman and ROA spectra of L-Serine and L-Cysteine dissolved in aqueous solution are computed and compared both with alternative theoretical approaches and experimental measurements.
{"title":"Effective fully polarizable QM/MM approaches to compute Raman and Raman Optical Activity spectra in aqueous solution.","authors":"Chiara Sepali, Piero Lafiosca, Sara Gómez, Tommaso Giovannini, Chiara Cappelli","doi":"10.1016/j.saa.2023.123485","DOIUrl":"10.1016/j.saa.2023.123485","url":null,"abstract":"<p><p>Raman and Raman Optical Activity (ROA) signals are amply affected by solvent effects, especially in the presence of strongly solute-solvent interactions such as Hydrogen Bonding (HB). In this work, we extend the fully atomistic polarizable Quantum Mechanics/Molecular Mechanics approach, based on the Fluctuating Charges and Fluctuating Dipoles force field to the calculation of Raman and ROA spectra. Such an approach is able to accurately describe specific HB interactions, by also accounting for anisotropic contributions due to the inclusion of fluctuating dipoles. To highlight the potentiality of the novel approach, Raman and ROA spectra of L-Serine and L-Cysteine dissolved in aqueous solution are computed and compared both with alternative theoretical approaches and experimental measurements.</p>","PeriodicalId":94213,"journal":{"name":"Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41224438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-15Epub Date: 2023-10-13DOI: 10.1016/j.saa.2023.123525
Yu Chai, Xiao-Ping Zheng, Ya-Peng Du, Yu Zhou, Yan-Zhen Zheng
Understanding the structural properties of ionic liquids (ILs) in azeotrope mixtures is crucial for designing and synthesizing IL entrainers tailored for extractive distillation. While extensive research has been conducted to comprehend the molecular properties of IL systems, much of this work has been limited to IL-cosolvent binary mixtures and fails to fully capture the essence of breaking azeotropy. In this study, we utilized Fourier-transform infrared spectroscopy (FTIR) and density functional theory (DFT) calculations to study the microstructure of the IL-azeotropic system. Leveraging the high resolution of excess spectroscopy and employing the methanol hydroxyl group as an effective probe, our research focused on the IL-acetonitrile-methanol mixtures. This approach enabled us to pinpoint species transformations during the mixing process, revealing the nature of phase equilibrium changes within the azeotrope. Consequently, our findings offer valuable insights into the microstructures of multicomponent solutions.
{"title":"A combination of FTIR and DFT to study the microstructure properties of ionic liquid-acetonitrile-methanol systems.","authors":"Yu Chai, Xiao-Ping Zheng, Ya-Peng Du, Yu Zhou, Yan-Zhen Zheng","doi":"10.1016/j.saa.2023.123525","DOIUrl":"10.1016/j.saa.2023.123525","url":null,"abstract":"<p><p>Understanding the structural properties of ionic liquids (ILs) in azeotrope mixtures is crucial for designing and synthesizing IL entrainers tailored for extractive distillation. While extensive research has been conducted to comprehend the molecular properties of IL systems, much of this work has been limited to IL-cosolvent binary mixtures and fails to fully capture the essence of breaking azeotropy. In this study, we utilized Fourier-transform infrared spectroscopy (FTIR) and density functional theory (DFT) calculations to study the microstructure of the IL-azeotropic system. Leveraging the high resolution of excess spectroscopy and employing the methanol hydroxyl group as an effective probe, our research focused on the IL-acetonitrile-methanol mixtures. This approach enabled us to pinpoint species transformations during the mixing process, revealing the nature of phase equilibrium changes within the azeotrope. Consequently, our findings offer valuable insights into the microstructures of multicomponent solutions.</p>","PeriodicalId":94213,"journal":{"name":"Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49686848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-15Epub Date: 2023-10-16DOI: 10.1016/j.saa.2023.123504
Chunyan Li, Lei Liu, Daohan Zhang
In this study, N-doped fluorescent carbon dots with aggregation enhanced emission (N-CDs) were synthesized by a simple and rapid microwave-assisted method using o-phenylenediamine (OPD) and urea as raw materials and water as solvent. The fluorescence quantum yield of N-CDs was 20.64 %. N-CDs can be applied as invisible inks for message encryption. Furthermore, the fluorescence intensity of N-CDs can be quenched by Fe3+ and enhanced by tetracycline (TC). Therefore, two fluorescent probes were simultaneously designed in this study. Namely, "turn-off" fluorescence probe for Fe3+ and "turn-on" fluorescence probe for TC. The linear detection range of Fe3+ is from 1 to 70 μM, and detection limit is 0.1011 μM; the linear detection range of TC is from 0.1 to 10 μM, and the detection limit can be as low as 0.0555 μM. In this paper, the mutual interference between Fe3+ and TC was investigated for the first time. The detection of Fe3+ and TC was made more accurate by optimizing pH conditions and adding masking agent.
{"title":"Aggregation enhanced emissive orange carbon dots for information encryption and detection of Fe<sup>3+</sup> and tetracycline.","authors":"Chunyan Li, Lei Liu, Daohan Zhang","doi":"10.1016/j.saa.2023.123504","DOIUrl":"10.1016/j.saa.2023.123504","url":null,"abstract":"<p><p>In this study, N-doped fluorescent carbon dots with aggregation enhanced emission (N-CDs) were synthesized by a simple and rapid microwave-assisted method using o-phenylenediamine (OPD) and urea as raw materials and water as solvent. The fluorescence quantum yield of N-CDs was 20.64 %. N-CDs can be applied as invisible inks for message encryption. Furthermore, the fluorescence intensity of N-CDs can be quenched by Fe<sup>3+</sup> and enhanced by tetracycline (TC). Therefore, two fluorescent probes were simultaneously designed in this study. Namely, \"turn-off\" fluorescence probe for Fe<sup>3+</sup> and \"turn-on\" fluorescence probe for TC. The linear detection range of Fe<sup>3+</sup> is from 1 to 70 μM, and detection limit is 0.1011 μM; the linear detection range of TC is from 0.1 to 10 μM, and the detection limit can be as low as 0.0555 μM. In this paper, the mutual interference between Fe<sup>3+</sup> and TC was investigated for the first time. The detection of Fe<sup>3+</sup> and TC was made more accurate by optimizing pH conditions and adding masking agent.</p>","PeriodicalId":94213,"journal":{"name":"Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49695603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-05Epub Date: 2023-09-09DOI: 10.1016/j.saa.2023.123382
Shiwen Li, Tian Li, Yaoyi Cai, Zekai Yao, Miaolei He
Rice flour is a raw material for various foods and is used as a substitute for wheat flour. However, some merchants adulterate rice flour with the illegal additive Rongalite to extend the shelf life and earn illegal profits. Rongalite is highly carcinogenic, and ingestion of more than 10 g can even cause death. high-performance liquid chromatography (HPLC) and mass spectrometry (MS) are currently the main methods for detecting food adulteration, however, the existing methods have many limitations, complex operation, expensive instrumentation, etc. Raman spectroscopy has the advantages of convenience and non-destructive samples, but Raman spectroscopy can be affected by interference such as fluorescence background that affects detection, in addition to the problem of difficult quantitative analysis due to nonlinear bias. In this article, we used the preprocessing method of Savitzky-Golay smoothing filtering and VTPspline to improve the quality of the spectra and proposed the SARNet, which combines autoencoder and residual network to achieve the quantitative analysis of Rongalite content in rice flour. The new model combines a linear model with a nonlinear model, which can solve the nonlinear problem effectively. Experiments showed that the new SARNet model achieved state-of-the-art results, achieving the best R2 of 0.9703 and RMSEP of 0.0075. The lowest Rongalite concentration detected by the portable Raman spectrometer was 0.49%. In summary, the proposed method using portable Raman spectroscopy combined with machine learning has low detection bias and high accuracy, which can realize quantitative analyses of adulterated Rongalite in rice flour quickly. The method provides an accurate and nondestructive analytical tool in the field of food detection.
{"title":"Rapid quantitative analysis of Rongalite adulteration in rice flour using autoencoder and residual-based model associated with portable Raman spectroscopy.","authors":"Shiwen Li, Tian Li, Yaoyi Cai, Zekai Yao, Miaolei He","doi":"10.1016/j.saa.2023.123382","DOIUrl":"10.1016/j.saa.2023.123382","url":null,"abstract":"<p><p>Rice flour is a raw material for various foods and is used as a substitute for wheat flour. However, some merchants adulterate rice flour with the illegal additive Rongalite to extend the shelf life and earn illegal profits. Rongalite is highly carcinogenic, and ingestion of more than 10 g can even cause death. high-performance liquid chromatography (HPLC) and mass spectrometry (MS) are currently the main methods for detecting food adulteration, however, the existing methods have many limitations, complex operation, expensive instrumentation, etc. Raman spectroscopy has the advantages of convenience and non-destructive samples, but Raman spectroscopy can be affected by interference such as fluorescence background that affects detection, in addition to the problem of difficult quantitative analysis due to nonlinear bias. In this article, we used the preprocessing method of Savitzky-Golay smoothing filtering and VTPspline to improve the quality of the spectra and proposed the SARNet, which combines autoencoder and residual network to achieve the quantitative analysis of Rongalite content in rice flour. The new model combines a linear model with a nonlinear model, which can solve the nonlinear problem effectively. Experiments showed that the new SARNet model achieved state-of-the-art results, achieving the best R<sup>2</sup> of 0.9703 and RMSEP of 0.0075. The lowest Rongalite concentration detected by the portable Raman spectrometer was 0.49%. In summary, the proposed method using portable Raman spectroscopy combined with machine learning has low detection bias and high accuracy, which can realize quantitative analyses of adulterated Rongalite in rice flour quickly. The method provides an accurate and nondestructive analytical tool in the field of food detection.</p>","PeriodicalId":94213,"journal":{"name":"Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41151673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}