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A novel colorimetric fluorescent probe for sensing bisulfite detection in plant and zebrafish. 一种用于检测植物和斑马鱼中亚硫酸氢盐的新型比色荧光探针。
Pub Date : 2024-01-15 Epub Date: 2023-10-18 DOI: 10.1016/j.saa.2023.123559
Qianqian Zhang, Xiaohong Tang, Yanjin Wang, Ajuan Song, Xiaopeng Yang, Dan Yin, Zezhi Zhang

Sulfur dioxide (SO2) and its derivatives (SO32- and HSO3-), are important active sulfur species that play significant roles in physiological processes. Fluorescence probe imaging technology, due to its high temporal and spatial resolution, real-time non-invasive and non-destructive detection, has emerged as a valuable tool for studying SO2 in biological systems. In this study, we presented a colorimetric fluorescent probe for the detection of HSO3-. The structure of probe TPN-BP consists of a triphenylamine group and a benzopyrylium group that are connected by a vinyl double bond. The benzopyrylium group in probe TPN-BP, which carries a positive charge, serves two important functions: enhancing water solubility, allowing for its effective use in fully aqueous environments, and acting as a fluorescence quencher for the triphenylamine group. Upon interaction with HSO3-, probe TPN-BP exhibited significantly increase in fluorescence at 480 nm, causing the solution to change from blue to colorless. Spectral experiments showed that probe TPN-BP showed quick response time (10 s), high sensitivity (12.7 nM), and excellent selectivity towards HSO3-. It is worth noting that probe TPN-BP has been successfully used for fluorescence imaging and detection of HSO3- in plants and zebrafish. The results of this study indicated that probe TPN-BP can be used as a promising tool for the research and monitoring of SO2 in living organisms.

二氧化硫(SO2)及其衍生物(SO32-和HSO3-)是重要的活性硫物种,在生理过程中发挥着重要作用。荧光探针成像技术由于其高时间和空间分辨率、实时无创和无损检测,已成为研究生物系统中SO2的一种有价值的工具。在本研究中,我们提出了一种用于检测HSO3-的比色荧光探针。探针TPN-BP的结构由三苯胺基和苯并吡喃基组成,它们通过乙烯基双键连接。探针TPN-BP中携带正电荷的苯并吡喃基团具有两个重要功能:提高水溶性,使其能够在全水环境中有效使用,以及作为三苯胺基团的荧光猝灭剂。在与HSO3-相互作用时,探针TPN-BP在480nm处表现出显著的荧光增加,导致溶液从蓝色变为无色。光谱实验表明,探针TPN-BP表现出快速响应时间(10s)、高灵敏度(12.7nM)和对HSO3-的优异选择性。值得注意的是,探针TPN-BP已成功用于植物和斑马鱼中HSO3-的荧光成像和检测。本研究结果表明,TPN-BP探针可作为一种很有前途的研究和监测活体中SO2的工具。
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引用次数: 0
Enhancement of K+ channel permeation by selective terahertz excitation. 通过选择性太赫兹激发增强K+通道渗透。
Pub Date : 2024-01-15 Epub Date: 2023-10-15 DOI: 10.1016/j.saa.2023.123538
Kaijie Wu, Yong He, Kun Chen, Mengda Cui, Zhikai Yang, Yifang Yuan, Yuchen Tian, Wenyu Peng

The optical excitation effects offer an opportunity to gain insights into the structure and the function of K+ channel, contributing to the prediction of possible targets for drug design and precision therapy. Although there has been increasing research attention on the modulation of ion permeation in K+ channel by terahertz electromagnetic (THz-EM) stimuli, little exploration has been conducted regarding the dependence of ion permeation on frequencies. By using two-dimensional (2D) infrared excitation spectrum calculation for the K+ channel, we have discovered that the frequency of 53.60 THz serves as an optimal excitation modulation mode. This mode leads to an almost twofold enhancement in the rate of K+ ion permeation and a tenfold increase in selectivity efficiency. These improvements can be attributed to the coupling mode matching of the excited properties of CO groups in the K+ channel. Our findings propose a promising application of terahertz technology to improve the performance of ion channels, nanomembrane sieves, nanodevices, as well as neural therapy.

光激发效应为深入了解K+通道的结构和功能提供了机会,有助于预测药物设计和精确治疗的可能靶点。尽管人们越来越关注太赫兹电磁(THz-EM)刺激对K+通道中离子渗透的调制,但很少对离子渗透对频率的依赖性进行探索。通过对K+通道的二维(2D)红外激发光谱计算,我们发现53.60THz的频率是最佳的激发调制模式。这种模式导致K+离子渗透速率几乎提高了两倍,选择性效率提高了十倍。这些改进可归因于K+通道中CO基团激发性质的耦合模式匹配。我们的发现提出了太赫兹技术在改善离子通道、纳米膜筛、纳米器件以及神经治疗方面的应用前景。
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引用次数: 0
Highly efficient determination of trace ascorbic acid in vitamin C tablets by boronate affinity-modified magnetic metal-organic frameworks. 硼酸根亲和修饰磁性金属有机骨架高效测定维生素C片中微量抗坏血酸。
Pub Date : 2024-01-15 Epub Date: 2023-10-19 DOI: 10.1016/j.saa.2023.123565
Tiantian Wan, Zulei Zhang, Hailong Wang, Yiwen Yang, Hongmei Wang, Jian Zhang, Yanbo Zeng, Lei Li

Ascorbic acid (AA) plays an important role in many life processes. The chronic nutritional deficiency of AA will lead to the symptoms of scurvy. Therefore, the sensitive quantitative detection of AA is most important in the pharmaceutical analysis, food industry and diagnostic application. In this study, a dual-functional magnetic metal-organic frameworks (Fe3O4@SiO2@UiO-PBA) nanoparticles was synthesized by modifying phenylboronic acid to the surface of magnetic UiO-66-NH2 via postsynthetic modification for selectively and sensitively florescent detection of AA. Due to the abundant amino groups and grafted phenylboronic acid, the proposed nanoparticles have the dual properties of hydrophilicity and boronate affinity. Under optimum conditions, the obtained Fe3O4@SiO2@UiO-PBA nanoparticles can detect AA within 30 s, and has a good linear relationship with the concentration of AA in the range of 5.0-60 μM with a detection limit of 2.5 μM (S/N = 3). In addition, the prepared Fe3O4@SiO2@UiO-PBA nanoparticles showed excellent selectivity and great potential application in the highly efficient determination of trace AA in vitamin C tablets. These results indicated that a convenient method was proposed to develop fluorescent probes for rapid and sensitive detection of trace AA in real samples.

抗坏血酸(AA)在许多生命过程中起着重要作用。AA的长期营养缺乏会导致坏血病的症状。因此,AA的灵敏定量检测在药物分析、食品工业和诊断应用中是最重要的。在本研究中,一种双功能磁性金属有机框架(Fe3O4@SiO2@通过对磁性UiO-66-NH2表面修饰苯基硼酸,合成了具有选择性和灵敏荧光检测AA的UiO-PBA)纳米粒子。在最佳条件下Fe3O4@SiO2@UiO PBA纳米粒子可在30s内检测AA,在5.0-60μM范围内与AA浓度呈良好的线性关系,检测限为2.5μM(s/N=3)。此外Fe3O4@SiO2@UiO-PBA纳米粒子在高效测定维生素C片中微量AA方面具有良好的选择性和应用潜力。这些结果表明,为开发荧光探针快速灵敏地检测真实样品中的痕量AA提供了一种方便的方法。
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引用次数: 0
New substituted 1,2,3-triazoles for ratiometric recognition to Fe3+ ions. 新型取代的1,2,3-三唑对Fe3+离子的比率识别。
Pub Date : 2024-01-15 Epub Date: 2023-10-18 DOI: 10.1016/j.saa.2023.123558
Natalia Selivanova, Marina Shulaeva, Vyacheslav Semenov, Yuriy Galyametdinov

Two novel click derived sensory systems for different derivatives connected via a triazole linkage have been developed as a component of a chemosensor with sensitive towards Fe3+ ions. The 1-octyl-4-carboxyl-1,2,3-triazole (TR1) system demonstrated sensitivity to calcium ion. The 1,3-bis(4-hydroxycarbamoyl-1,2,3-triazol-1-yl)xylylene (TR2) system was shown to possess a preferential detection capability as a colorimetric probe for Fe3+ ions by exhibiting an obvious pH-dependent color change from colorless to pink. Complexation of the ligands with Fe3+ ions was studied. The 1:1 stoichiometry and bonding sites of TR1-Fe3+, and TR2-Fe3+ complexes were elucidated by analyzing the Job plot. The association constants of 5.35 × 105 M1 for TR1- Fe3+ and 3.58 × 104 M1 for TR2-Fe3+ and detection limits 1.68 × 10-8 and 2.52 × 10-7 were determined from standard deviation and linear fittings.

已经开发了两种用于不同衍生物的新型点击衍生传感系统,它们通过三唑键连接,作为对Fe3+离子敏感的化学传感器的组件。1-辛基-4-羧基-1,2,3-三唑(TR1)体系对钙离子具有敏感性。1,3-双(4-羟基氨基甲酰基-1,2,3-三唑-1-基)亚二甲苯(TR2)体系表现出从无色到粉红色的明显的pH依赖性颜色变化,显示出作为Fe3+离子的比色探针的优先检测能力。研究了配体与Fe3+离子的络合反应。通过分析Job图,阐明了TR1-Fe3+和TR2-Fe3+配合物的1:1化学计量和结合位点。用标准偏差和线性拟合方法测定了TR1-Fe3+的缔合常数5.35×105M1和TR2-Fe3+的3.58×104M1,检出限1.68×10-8和2.52×10-7。
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引用次数: 0
Simple turn-on fluorescent chemosensor for ultrafast and highly selective trace-level detection of Cu2+ ions in aqueous solutions. 简单的开启荧光化学传感器,用于水溶液中Cu2+离子的超快速和高选择性痕量检测。
Pub Date : 2024-01-15 Epub Date: 2023-10-18 DOI: 10.1016/j.saa.2023.123555
Seonmin Park, So Yeon Bong, Shilpa Sharma, Narinder Singh, Yea-In Park, Junsoo Park, Doo Ok Jang

A benzimidazole-based probe, BIPMA (2-(1H-benzo[d]imidazol-2-yl)-N-(pyridin-2-ylmethyl)aniline), was designed and synthesized to detect Cu2+ ions. BIPMA exhibited a fluorescent "turn-on" mechanism when bound to Cu2+ ions in an acetonitrile/water mixture (5:5, v/v, HEPES 10 mM, pH 7.4) owing to the synergistic effect of the chelation-enhanced fluorescence and internal charge-transfer mechanisms. Moreover, the BIPMA probe effectively detected nanomolar-range concentrations (0-400 nM) of Cu2+ ions in an aqueous system with a detection limit of 4.80 nM; this value is significantly lower than that set by the U.S. Environmental Protection Agency (≈20 μM). Additionally, BIPMA showed an ultrafast response to Cu2+ ions, with a maximum intensity achieved 25 s after adding Cu2+. Furthermore, BIPMA detected Cu2+ ions in solutions with a pH range of 5-11, without being influenced by pH, underscoring its applicability under various physiological conditions. Density functional theory studies revealed that internal charge transfer was responsible for emission. Finally, BIPMA effectively detected Cu2+ ions in real water samples and living cells.

设计并合成了一种基于苯并咪唑的探针BIPMA(2-(1H-苯并[d]咪唑-2-基)-N-(吡啶-2-基甲基)苯胺)来检测Cu2+离子。当在乙腈/水混合物(5:5,v/v,HEPES 10mM,pH 7.4)中与Cu2+离子结合时,由于螯合增强的荧光和内部电荷转移机制的协同作用,BIPMA表现出荧光“开启”机制。此外,BIPMA探针有效地检测到水性系统中Cu2+离子的纳摩尔范围浓度(0-400nM),检测极限为4.80nM;这个数值明显低于美国环境保护局设定的数值(≈20μM)。此外,BIPMA对Cu2+离子表现出超快的响应,在添加Cu2+后25秒达到最大强度。此外,BIPMA在pH范围为5-11的溶液中检测到Cu2+离子,不受pH的影响,强调了其在各种生理条件下的适用性。密度泛函理论研究表明,内部电荷转移是发射的原因。最后,BIPMA有效地检测了真实水样和活细胞中的Cu2+离子。
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引用次数: 0
Simultaneous estimation of two anti-diabetic drugs; Linagliptin and empagliflozin in their tablet by chemometric spectrophotometry. 两种抗糖尿病药物的同时评价;化学计量分光光度法测定利那列汀和恩帕列嗪片剂中利那列肽和恩帕列嗪的含量。
Pub Date : 2024-01-15 Epub Date: 2023-10-17 DOI: 10.1016/j.saa.2023.123556
Amira H Kamal, Sherin F Hammad, Mohamed M Salim, Mahmoud M Elkhodary, Aya A Marie

Four spectrophotometric approaches had been established and optimized for the simultaneous estimation of two anti-diabetic drugs; linagliptin (LIN) and empagliflozin (EMP) in their bulk and tablet dosage form. LIN concentration could be first determined from the zero order spectra at its λmax (293 nm) without interference from EMP as at this wavelength EMP showed zero absorbance. The LIN and EMP zero order absorption spectra displayed considerable overlap which hindered the direct determination of EMP. Thus, four indirect spectrophotometric approaches were established and optimized for the determination and quantification of EMP concentrations in presence of LIN. Method (I) was ratio difference method (RD) which depended on the determination of difference amplitudes in the ratio spectra (ΔP) at 236 nm and 227 nm; ΔP(236-227) was directly proportional to EMP concentration. Method (II) was ratio derivative method (1DD) based on the measuring of the amplitude of first derivative of ratio spectra at 243 nm which was directly proportional to EMP concentration. For determination of EMP concentration using both method (I) and (II); LIN 7 µg/mL was used as the divisor. Method (III) was area under curve method (AUC) which depended on the measurement of area confined between 220 and 230 nm and 273-290 nm. Method (IV) was dual wavelength method (DWL) which based on measurement of absorbance difference (ΔA) in zero order spectra between 239.8 and 282.6 nm which was directly proportional to EMP concentration. The four developed methods were optimized and entirely validated regarding to ICH guidelines. The proposed spectrophotometric approaches were used for the quantification of LIN and EMP simultaneously in their tablet dosage form. F-test and t-test were applied for statistical comparison between the results obtained by the proposed approaches and that obtained by the reported method. There was no significant difference concerning to precision and accuracy.

建立并优化了四种分光光度法同时测定两种抗糖尿病药物;利格列汀(LIN)和恩帕列嗪(EMP)的散装和片剂剂型。在没有EMP干扰的情况下,可以首先从λmax(293nm)的零阶光谱中测定LIN浓度,因为在该波长下,EMP显示出零吸光度。LIN和EMP的零级吸收光谱显示出相当大的重叠,这阻碍了EMP的直接测定。因此,建立并优化了四种间接分光光度法来测定和定量在LIN存在下的EMP浓度。方法(I)为比值差法(RD),该方法依赖于测定236 nm和227 nm处比值光谱(ΔP)的差幅;ΔP(236-227)与EMP浓度成正比。方法(II)是基于在243nm处测量与EMP浓度成正比的比率光谱的一阶导数幅度的比率导数方法(1DD)。用于使用方法(I)和(II)测定EMP浓度;LIN 7µg/mL用作除数。方法(III)是曲线下面积法(AUC),其取决于限制在220和230nm以及273-290nm之间的面积的测量。方法(IV)是双波长法(DWL),其基于在239.8和282.6nm之间的零阶光谱中的吸光度差(ΔA)的测量,该吸光度差与EMP浓度成正比。根据ICH指南,对四种开发的方法进行了优化和完全验证。将所提出的分光光度法同时用于片剂中LIN和EMP的定量。使用F检验和t检验对所提出的方法和所报道的方法获得的结果进行统计比较。在精确度和准确性方面没有显著差异。
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引用次数: 0
Effective fully polarizable QM/MM approaches to compute Raman and Raman Optical Activity spectra in aqueous solution. 计算水溶液中拉曼和拉曼光学活性光谱的有效全极化QM/MM方法。
Pub Date : 2024-01-15 Epub Date: 2023-10-05 DOI: 10.1016/j.saa.2023.123485
Chiara Sepali, Piero Lafiosca, Sara Gómez, Tommaso Giovannini, Chiara Cappelli

Raman and Raman Optical Activity (ROA) signals are amply affected by solvent effects, especially in the presence of strongly solute-solvent interactions such as Hydrogen Bonding (HB). In this work, we extend the fully atomistic polarizable Quantum Mechanics/Molecular Mechanics approach, based on the Fluctuating Charges and Fluctuating Dipoles force field to the calculation of Raman and ROA spectra. Such an approach is able to accurately describe specific HB interactions, by also accounting for anisotropic contributions due to the inclusion of fluctuating dipoles. To highlight the potentiality of the novel approach, Raman and ROA spectra of L-Serine and L-Cysteine dissolved in aqueous solution are computed and compared both with alternative theoretical approaches and experimental measurements.

拉曼和拉曼光学活性(ROA)信号充分受到溶剂效应的影响,特别是在存在强溶质-溶剂相互作用(如氢键(HB))的情况下。在这项工作中,我们将基于波动电荷和波动偶极子力场的全原子极化量子力学/分子力学方法扩展到拉曼光谱和ROA光谱的计算中。这种方法能够准确地描述特定的HB相互作用,同时也考虑到由于包含波动偶极子而产生的各向异性贡献。为了突出新方法的潜力,计算了溶解在水溶液中的L-丝氨酸和L-半胱氨酸的拉曼光谱和ROA光谱,并与其他理论方法和实验测量结果进行了比较。
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引用次数: 0
A combination of FTIR and DFT to study the microstructure properties of ionic liquid-acetonitrile-methanol systems. FTIR和DFT相结合研究了离子液体乙腈-甲醇体系的微观结构特性。
Pub Date : 2024-01-15 Epub Date: 2023-10-13 DOI: 10.1016/j.saa.2023.123525
Yu Chai, Xiao-Ping Zheng, Ya-Peng Du, Yu Zhou, Yan-Zhen Zheng

Understanding the structural properties of ionic liquids (ILs) in azeotrope mixtures is crucial for designing and synthesizing IL entrainers tailored for extractive distillation. While extensive research has been conducted to comprehend the molecular properties of IL systems, much of this work has been limited to IL-cosolvent binary mixtures and fails to fully capture the essence of breaking azeotropy. In this study, we utilized Fourier-transform infrared spectroscopy (FTIR) and density functional theory (DFT) calculations to study the microstructure of the IL-azeotropic system. Leveraging the high resolution of excess spectroscopy and employing the methanol hydroxyl group as an effective probe, our research focused on the IL-acetonitrile-methanol mixtures. This approach enabled us to pinpoint species transformations during the mixing process, revealing the nature of phase equilibrium changes within the azeotrope. Consequently, our findings offer valuable insights into the microstructures of multicomponent solutions.

了解共沸混合物中离子液体的结构性质对于设计和合成适用于萃取蒸馏的离子液体夹带剂至关重要。虽然已经进行了广泛的研究来理解IL系统的分子性质,但这项工作大多局限于IL共溶剂二元混合物,未能完全捕捉到打破共沸的本质。在本研究中,我们利用傅里叶变换红外光谱(FTIR)和密度泛函理论(DFT)计算来研究IL共沸体系的微观结构。利用过量光谱的高分辨率,并使用甲醇羟基作为有效的探针,我们的研究重点是IL-乙腈-甲醇混合物。这种方法使我们能够精确定位混合过程中的物种转变,揭示共沸物内相平衡变化的性质。因此,我们的发现为多组分溶液的微观结构提供了有价值的见解。
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引用次数: 0
Aggregation enhanced emissive orange carbon dots for information encryption and detection of Fe3+ and tetracycline. 聚集增强发射橙色碳点,用于信息加密和检测Fe3+和四环素。
Pub Date : 2024-01-15 Epub Date: 2023-10-16 DOI: 10.1016/j.saa.2023.123504
Chunyan Li, Lei Liu, Daohan Zhang

In this study, N-doped fluorescent carbon dots with aggregation enhanced emission (N-CDs) were synthesized by a simple and rapid microwave-assisted method using o-phenylenediamine (OPD) and urea as raw materials and water as solvent. The fluorescence quantum yield of N-CDs was 20.64 %. N-CDs can be applied as invisible inks for message encryption. Furthermore, the fluorescence intensity of N-CDs can be quenched by Fe3+ and enhanced by tetracycline (TC). Therefore, two fluorescent probes were simultaneously designed in this study. Namely, "turn-off" fluorescence probe for Fe3+ and "turn-on" fluorescence probe for TC. The linear detection range of Fe3+ is from 1 to 70 μM, and detection limit is 0.1011 μM; the linear detection range of TC is from 0.1 to 10 μM, and the detection limit can be as low as 0.0555 μM. In this paper, the mutual interference between Fe3+ and TC was investigated for the first time. The detection of Fe3+ and TC was made more accurate by optimizing pH conditions and adding masking agent.

本研究以邻苯二胺(OPD)和尿素为原料,以水为溶剂,采用简单快速的微波辅助方法合成了具有聚集增强发射的N掺杂荧光碳点(N-CDs)。N-CDs的荧光量子产率为20.64%。N-CDs可以作为不可见墨水用于消息加密。此外,Fe3+可以猝灭N-CDs的荧光强度,四环素(TC)可以增强其荧光强度。因此,本研究同时设计了两种荧光探针。即Fe3+“关”荧光探针,TC“开”荧光探针。Fe3+的线性检测范围为1~70μM,检测限为0.1011μM;TC的线性检测范围为0.1-10μM,检测限可低至0.0555μM。本文首次研究了Fe3+与TC之间的相互干扰。通过优化pH条件和添加掩蔽剂,使Fe3+和TC的检测更加准确。
{"title":"Aggregation enhanced emissive orange carbon dots for information encryption and detection of Fe<sup>3+</sup> and tetracycline.","authors":"Chunyan Li,&nbsp;Lei Liu,&nbsp;Daohan Zhang","doi":"10.1016/j.saa.2023.123504","DOIUrl":"10.1016/j.saa.2023.123504","url":null,"abstract":"<p><p>In this study, N-doped fluorescent carbon dots with aggregation enhanced emission (N-CDs) were synthesized by a simple and rapid microwave-assisted method using o-phenylenediamine (OPD) and urea as raw materials and water as solvent. The fluorescence quantum yield of N-CDs was 20.64 %. N-CDs can be applied as invisible inks for message encryption. Furthermore, the fluorescence intensity of N-CDs can be quenched by Fe<sup>3+</sup> and enhanced by tetracycline (TC). Therefore, two fluorescent probes were simultaneously designed in this study. Namely, \"turn-off\" fluorescence probe for Fe<sup>3+</sup> and \"turn-on\" fluorescence probe for TC. The linear detection range of Fe<sup>3+</sup> is from 1 to 70 μM, and detection limit is 0.1011 μM; the linear detection range of TC is from 0.1 to 10 μM, and the detection limit can be as low as 0.0555 μM. In this paper, the mutual interference between Fe<sup>3+</sup> and TC was investigated for the first time. The detection of Fe<sup>3+</sup> and TC was made more accurate by optimizing pH conditions and adding masking agent.</p>","PeriodicalId":94213,"journal":{"name":"Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49695603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Rapid quantitative analysis of Rongalite adulteration in rice flour using autoencoder and residual-based model associated with portable Raman spectroscopy. 使用自动编码器和基于残差的便携式拉曼光谱模型快速定量分析米粉中的荣阿利特掺假。
Pub Date : 2024-01-05 Epub Date: 2023-09-09 DOI: 10.1016/j.saa.2023.123382
Shiwen Li, Tian Li, Yaoyi Cai, Zekai Yao, Miaolei He

Rice flour is a raw material for various foods and is used as a substitute for wheat flour. However, some merchants adulterate rice flour with the illegal additive Rongalite to extend the shelf life and earn illegal profits. Rongalite is highly carcinogenic, and ingestion of more than 10 g can even cause death. high-performance liquid chromatography (HPLC) and mass spectrometry (MS) are currently the main methods for detecting food adulteration, however, the existing methods have many limitations, complex operation, expensive instrumentation, etc. Raman spectroscopy has the advantages of convenience and non-destructive samples, but Raman spectroscopy can be affected by interference such as fluorescence background that affects detection, in addition to the problem of difficult quantitative analysis due to nonlinear bias. In this article, we used the preprocessing method of Savitzky-Golay smoothing filtering and VTPspline to improve the quality of the spectra and proposed the SARNet, which combines autoencoder and residual network to achieve the quantitative analysis of Rongalite content in rice flour. The new model combines a linear model with a nonlinear model, which can solve the nonlinear problem effectively. Experiments showed that the new SARNet model achieved state-of-the-art results, achieving the best R2 of 0.9703 and RMSEP of 0.0075. The lowest Rongalite concentration detected by the portable Raman spectrometer was 0.49%. In summary, the proposed method using portable Raman spectroscopy combined with machine learning has low detection bias and high accuracy, which can realize quantitative analyses of adulterated Rongalite in rice flour quickly. The method provides an accurate and nondestructive analytical tool in the field of food detection.

米粉是各种食品的原料,是小麦粉的替代品。然而,一些商家在米粉中掺入非法添加剂荣阿利特,以延长保质期,赚取非法利润。容阿利特具有高度致癌性,摄入超过10克甚至会导致死亡。高效液相色谱法(HPLC)和质谱法(MS)是目前检测食品掺假的主要方法,但现有方法局限性大、操作复杂、仪器昂贵等。拉曼光谱法具有样品方便、无损等优点,但是拉曼光谱除了由于非线性偏置而难以进行定量分析的问题之外还可能受到诸如影响检测的荧光背景的干扰的影响。本文采用Savitzky Golay平滑滤波和VTPspline的预处理方法来提高光谱的质量,并提出了将自动编码器和残差网络相结合的SARNet,实现了米粉中容阿利特含量的定量分析。该模型将线性模型与非线性模型相结合,能够有效地解决非线性问题。实验表明,新的SARNet模型取得了最先进的结果,获得了0.9703的最佳R2和0.0075的RMSEP。便携式拉曼光谱仪检测到的最低容阿利特浓度为0.49%。总之,所提出的便携式拉曼光谱与机器学习相结合的方法检测偏差低,精度高,可以快速实现米粉中掺伪容阿利特的定量分析。该方法为食品检测领域提供了一种准确、无损的分析工具。
{"title":"Rapid quantitative analysis of Rongalite adulteration in rice flour using autoencoder and residual-based model associated with portable Raman spectroscopy.","authors":"Shiwen Li,&nbsp;Tian Li,&nbsp;Yaoyi Cai,&nbsp;Zekai Yao,&nbsp;Miaolei He","doi":"10.1016/j.saa.2023.123382","DOIUrl":"10.1016/j.saa.2023.123382","url":null,"abstract":"<p><p>Rice flour is a raw material for various foods and is used as a substitute for wheat flour. However, some merchants adulterate rice flour with the illegal additive Rongalite to extend the shelf life and earn illegal profits. Rongalite is highly carcinogenic, and ingestion of more than 10 g can even cause death. high-performance liquid chromatography (HPLC) and mass spectrometry (MS) are currently the main methods for detecting food adulteration, however, the existing methods have many limitations, complex operation, expensive instrumentation, etc. Raman spectroscopy has the advantages of convenience and non-destructive samples, but Raman spectroscopy can be affected by interference such as fluorescence background that affects detection, in addition to the problem of difficult quantitative analysis due to nonlinear bias. In this article, we used the preprocessing method of Savitzky-Golay smoothing filtering and VTPspline to improve the quality of the spectra and proposed the SARNet, which combines autoencoder and residual network to achieve the quantitative analysis of Rongalite content in rice flour. The new model combines a linear model with a nonlinear model, which can solve the nonlinear problem effectively. Experiments showed that the new SARNet model achieved state-of-the-art results, achieving the best R<sup>2</sup> of 0.9703 and RMSEP of 0.0075. The lowest Rongalite concentration detected by the portable Raman spectrometer was 0.49%. In summary, the proposed method using portable Raman spectroscopy combined with machine learning has low detection bias and high accuracy, which can realize quantitative analyses of adulterated Rongalite in rice flour quickly. The method provides an accurate and nondestructive analytical tool in the field of food detection.</p>","PeriodicalId":94213,"journal":{"name":"Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41151673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
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