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Trace element imbalance as a possible factor in long-COVID pathophysiology: Links to disease duration and inflammation. 微量元素失衡是长期covid病理生理的可能因素:与疾病持续时间和炎症有关。
IF 1.8 Pub Date : 2025-10-21 DOI: 10.1016/j.amjms.2025.10.013
Wasim Talib Al Masoodi, Sami Waheed Radhi, Hussein Kadhem Al-Hakeim, Habiba Khdair Abdalsada

Background: Long-COVID is defined by persistent symptoms following an initial COVID-19 infection. The normal immune function depends on a precise balance of trace elements, which can provide fresh insights into prospective therapeutic strategies while maintaining oxidative balance and limiting excessive inflammation. Zinc, copper, cobalt, and manganese deficits or excesses can alter the immune system's normal functions and oxidative stress. The study aims to study the trace element profile for predicting long-COVID.

Methods: The levels of serum copper and zinc were measured spectrophotometrically. In contrast, cobalt and manganese were measured using flameless atomic absorption spectrophotometry in 60 long-COVID patients and compared with the 30 controls who had previous SARS-CoV-2 infection but were free from long-COVID symptoms.

Results: Serum levels of copper, cobalt, manganese, and the copper/zinc ratio were considerably elevated in long-COVID patients compared to the control groups. Nonetheless, there was no significant change in zinc levels relative to the control group. The cobalt concentration increases with the duration of the disease and inflammation. Serum manganese level is significantly and negatively correlated with weight. The duration of disease is inversely linked to serum zinc concentrations. There is a substantial correlation between serum copper levels and the period of recovery from acute SARS-CoV-2 infection.

Conclusions: Long-COVID is associated with alterations in serum trace elements (copper, cobalt, and manganese). The imbalances in the trace elements are associated with inflammation, duration of disease, and age. These imbalances may contribute to prolonged symptoms and greater disease severity, suggesting that trace element monitoring could be beneficial in managing long-COVID.

背景:长covid是指初始COVID-19感染后持续出现症状。正常的免疫功能依赖于微量元素的精确平衡,这可以为未来的治疗策略提供新的见解,同时保持氧化平衡和限制过度炎症。锌、铜、钴和锰缺乏或过量会改变免疫系统的正常功能和氧化应激。本研究旨在研究预测长冠状病毒的微量元素剖面。方法:采用分光光度法测定血清铜、锌含量。相比之下,使用无焰原子吸收分光光度法测量了60名长期covid患者的钴和锰含量,并与之前感染过SARS-CoV-2但没有长期covid症状的30名对照组进行了比较。结果:与对照组相比,长冠患者血清铜、钴、锰水平和铜锌比明显升高。尽管如此,与对照组相比,锌含量没有明显变化。钴浓度随疾病和炎症的持续时间而增加。血清锰水平与体重呈显著负相关。疾病持续时间与血清锌浓度呈负相关。血清铜水平与急性SARS-CoV-2感染恢复期之间存在显著相关性。结论:长covid与血清微量元素(铜、钴和锰)的改变有关。微量元素的失衡与炎症、疾病持续时间和年龄有关。这些不平衡可能导致症状延长和疾病严重程度加重,这表明微量元素监测可能有助于长期控制covid。
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引用次数: 0
Trends in hypertensive renal disease with renal failure-related mortality among gender ethnicity and states in the United States from 1999-2020. 1999-2020年美国性别、种族和各州高血压肾病伴肾衰竭相关死亡率趋势
IF 1.8 Pub Date : 2025-10-10 DOI: 10.1016/j.amjms.2025.10.003
Muhammad Shaheer Bin Faheem, Faiza Ikram, Muhammad Saad Iqbal, Muhammad Owais Mazhar, Hurmat Fatima, Awais Akhtar, Uzair Irfan, Muhammad Omar Ashfaq, Ahmed Faraz, Raheel Ahmed

Background: Hypertensive renal disease impacts approximately 753 million individuals worldwide each year. This study evaluates trends in hypertensive renal disease mortality from 1999 to 2020 in the US, focusing on disparities related to gender, race, and urbanization by examining the Age-Adjusted Mortality Rate (AAMR) to inform targeted intervention and improve outcomes.

Methods: The CDC WONDER database analyzed hypertensive renal disease with renal-failure-related mortality from 1999 to 2020, calculating mortality rates and a 95 % confidence interval to assess national trends.

Results: Throughout the study period, males constantly exhibited a higher Age-Adjusted Mortality Rates (AAMR) for hypertensive renal disease with renal-failure-related mortality 148.92 (95 % CI: 148.37 - 149.48) than females 106.11 (95 % CI: 105.73 - 106.49). African American individuals exhibited the highest overall AAMR at 286.29 (95 % CI: 284.68 - 287.9), starting at 186.23 in 1999 (95 % CI: 179.34 - 193.13) and increasing to 529.72 in 2020 (APC: 5.27; 95 % CI: 520.77 - 538.67). From 1999 to 2020, AAMR rose in metropolitan areas from 197.57 (95 % CI: 187.88-207.26) to 1112.12 (APC: 10.00; 95 % CI: 1093.39-1130.85), and in non-metropolitan areas from 97.35 (95 % CI: 90.63-104.08) to 643.06 (APC: 11.81; 95 % CI: 627.76-658.37).AAMRs varied significantly by state, from 61.23 (95 % CI: 59.29-63.16) in Connecticut to 225.06 (95 % CI: 214.96-235.16) in the District of Columbia.

Conclusions: From 1999 to 2020, the mortality rate from hypertensive-related renal diseases rose uncertainly, with a sharp incline starting from 2013 to a sudden surge in 2020 due to COVID-19-related renal complications. Higher deaths were observed in males, African American ethnicity, and individuals living in non-metropolitan areas. Addressing these problems requires a multifactorial public health approach focusing on early detection, equitable care, and targeted intervention to reduce disease burden.

背景:高血压肾病每年影响全球约7.53亿人。本研究评估了1999年至2020年美国高血压肾病死亡率的趋势,通过检查年龄调整死亡率(AAMR),重点关注与性别、种族和城市化相关的差异,为有针对性的干预和改善结果提供信息。方法:CDC WONDER数据库分析1999年至2020年伴有肾衰竭相关死亡率的高血压肾病,计算死亡率和95%置信区间,以评估全国趋势。结果:在整个研究期间,男性高血压肾病的年龄调整死亡率(AAMR)一直较高,肾功能衰竭相关死亡率为148.92 (95% CI: 148.37 - 149.48),而女性为106.11 (95% CI: 105.73 - 106.49)。非洲裔美国人的总体AAMR最高,为286.29 (95% CI: 284.68 ~ 287.9),从1999年的186.23 (95% CI: 179.34 ~ 193.13)开始,到2020年增加到529.72 (APC: 5.27; 95% CI: 520.77 ~ 538.67)。从1999年到2020年,大城市地区的AAMR从197.57 (95% CI: 187.88 ~ 207.26)上升到1112.12 (APC: 10.00, 95% CI: 1093.39 ~ 1130.85),非大城市地区从97.35 (95% CI: 90.63 ~ 104.08)上升到643.06 (APC: 11.81, 95% CI: 627.76 ~ 658.37)。aamr因州而异,从康涅狄格州的61.23 (95% CI: 59.29-63.16)到哥伦比亚特区的225.06 (95% CI: 214.96-235.16)。结论:1999 - 2020年高血压相关肾脏疾病死亡率呈不确定性上升趋势,2013年开始呈急剧上升趋势,2020年因新冠肺炎相关肾脏并发症出现突然上升。在男性、非裔美国人和居住在非大都市地区的个人中观察到较高的死亡率。解决这些问题需要多因素的公共卫生方法,侧重于早期发现、公平护理和有针对性的干预,以减轻疾病负担。
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引用次数: 0
Targeting the ROS-ferroptosis axis: A clinical perspective on oxidative stress management in systemic lupus erythematosus. 针对ros -铁下垂轴:系统性红斑狼疮氧化应激管理的临床观点。
IF 1.8 Pub Date : 2025-10-03 DOI: 10.1016/j.amjms.2025.10.001
Xiaoyan Xu, Wenfeng Gao, Lei Pang, Yiming Chen, Shuijing Liang, Xiaodong Wang

Systemic lupus erythematosus (SLE) is a classic autoimmune condition marked by inflammation in multiple organs and a malfunctioning immune system. Despite advances in immunosuppressive therapies, patients frequently experience relapses, organ damage, and significant quality-of-life impairment. Recent findings indicate that ferroptosis, a form of regulated cell death dependent on iron, has a substantial impact on the progression of lupus. However, the precise molecular interplay between ROS generation, iron metabolism dysregulation, and immune cell dysfunction in SLE remains incompletely understood. This review analyzes the ROS-ferroptosis axis in SLE, highlighting its role in promoting pathological immune responses and worsening tissue injury. It also discusses targeted therapies like iron chelators and GPX4 agonists, which show promise in preclinical models and early trials, identifies actionable targets, evaluates their translational potential for precision therapies, and bridges preclinical mechanisms with clinical applications to address unmet SLE management needs.

系统性红斑狼疮(SLE)是一种典型的自身免疫性疾病,其特征是多器官炎症和免疫系统功能失调。尽管免疫抑制疗法取得了进展,但患者经常经历复发、器官损伤和显著的生活质量损害。最近的研究结果表明,铁下垂,一种依赖铁的调节细胞死亡形式,对狼疮的进展有重大影响。然而,在SLE中,ROS生成、铁代谢失调和免疫细胞功能障碍之间的确切分子相互作用仍不完全清楚。本文对SLE中的ros -铁下垂轴进行分析,强调其在促进病理性免疫反应和加重组织损伤中的作用。它还讨论了靶向治疗,如铁螯合剂和GPX4激动剂,它们在临床前模型和早期试验中显示出前景,确定了可操作的靶点,评估了它们在精确治疗方面的转化潜力,并将临床前机制与临床应用联系起来,以解决未满足的SLE管理需求。
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引用次数: 0
Relationship between depression and chronic liver disease: Potential role of antidepressants in modulating liver fibrosis. 抑郁症与慢性肝病的关系:抗抑郁药在调节肝纤维化中的潜在作用
IF 1.8 Pub Date : 2025-10-01 DOI: 10.1016/j.amjms.2025.07.018
Ahmad Basil Nasir, Spyridon Zouridis, Patricia Aspichueta, Paul Manka, Wing-Kin Syn

Depression is a frequent comorbidity in chronic liver disease (CLD), including Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), viral hepatitis, autoimmune hepatitis (AIH), primary sclerosing cholangitis (PSC), primary biliary cholangitis (PBC), hemochromatosis, and Wilson's disease. It is associated with worse outcomes, accelerated disease progression, increased hospitalizations, and higher mortality. While antidepressants are commonly prescribed, their effects on liver disease, particularly on liver fibrosis, remain underexplored. This narrative review examines the relationship between depression, CLD, and antidepressants through a literature review of studies published between 2010 and 2024. Some evidence suggests that antidepressants may have antifibrotic properties, as seen in pulmonary fibrosis, but liver-specific data are limited. Understanding their potential role in both mental health and liver disease management could improve patient outcomes. However, significant research gaps remain, and further clinical trials are needed to determine whether antidepressants influence liver fibrosis, disease progression, and overall prognosis in CLD.

抑郁症是慢性肝病(CLD)的常见合并症,包括代谢功能障碍相关脂肪变性肝病(MASLD)、病毒性肝炎、自身免疫性肝炎(AIH)、原发性硬化性胆管炎(PSC)、原发性胆管炎(PBC)、血色素沉着症和Wilson病。它与较差的预后、加速疾病进展、住院率增加和死亡率升高有关。虽然抗抑郁药通常被开处方,但它们对肝脏疾病的影响,特别是对肝纤维化的影响,仍未得到充分研究。本文通过对2010年至2024年间发表的研究文献的回顾,探讨了抑郁症、CLD和抗抑郁药之间的关系。一些证据表明抗抑郁药可能具有抗纤维化特性,如在肺纤维化中所见,但肝脏特异性数据有限。了解它们在精神健康和肝脏疾病管理中的潜在作用可以改善患者的预后。然而,重大的研究空白仍然存在,需要进一步的临床试验来确定抗抑郁药是否影响肝纤维化、疾病进展和CLD的总体预后。
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引用次数: 0
Changes in perceived neighborhood environments by COVID-19: A nationwide Korean survey. 新冠肺炎对邻里环境感知的变化——韩国全国调查。
IF 1.8 Pub Date : 2025-09-16 DOI: 10.1016/j.amjms.2025.09.008
Ki Dong Ko, In Cheol Hwang, Hong Yup Ahn
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引用次数: 0
Vagus nerve stimulation as a novel therapeutic approach for musculoskeletal diseases. 迷走神经刺激作为一种治疗肌肉骨骼疾病的新方法。
IF 1.8 Pub Date : 2025-09-04 DOI: 10.1016/j.amjms.2025.09.005
Shivmurat Yadav, Stavros Stavrakis, Constance R Chu, Mary Beth Humphrey

Vagus nerve stimulation (VNS) has gained significant attention as a therapy for various medical conditions due to its ability to modulate chronic diseases, pain, and inflammation. VNS delivered by an implanted device is FDA approved for severe epilepsy and refractory depression. VNS delivered with implantable devices or transcutaneous methods are now being studied in several musculoskeletal diseases including osteoarthritis, rheumatoid arthritis, systemic lupus erythematosus, and fibromyalgia. VNS activates the neuroimmune axis including the cholinergic anti-inflammatory pathway (CAP), suppressing inflammation and reducing pain. Here, we review the pathophysiology of VNS and the outcomes from clinical trials in musculoskeletal diseases. We address the limitations of these studies, including the inconsistent use of physiological biomarkers, such as heart rate variability, to ensure that VNS is engaging the vagus nerve. More studies are required to reveal the full potential of VNS for pain reduction and disease modification.

迷走神经刺激(VNS)由于其调节慢性疾病、疼痛和炎症的能力,作为一种治疗各种疾病的方法,已经受到了极大的关注。由植入装置提供的VNS是FDA批准用于严重癫痫和难治性抑郁症的。通过植入式装置或经皮方法提供的VNS目前正在研究几种肌肉骨骼疾病,包括骨关节炎、类风湿关节炎、系统性红斑狼疮和纤维肌痛。VNS激活包括胆碱能抗炎通路(CAP)在内的神经免疫轴,抑制炎症,减轻疼痛。在此,我们回顾了VNS在肌肉骨骼疾病中的病理生理学和临床试验的结果。我们解决了这些研究的局限性,包括使用不一致的生理生物标志物,如心率变异性,以确保VNS参与迷走神经。需要更多的研究来揭示VNS在减轻疼痛和改善疾病方面的全部潜力。
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引用次数: 0
CircCOL3A1 ameliorates myocardial ischemia-reperfusion injury by regulating miR-29b-3p/MDM2-mediated apoptosis. CircCOL3A1通过调节miR-29b-3p/ mdm2介导的细胞凋亡改善心肌缺血再灌注损伤。
IF 1.8 Pub Date : 2025-08-28 DOI: 10.1016/j.amjms.2025.08.021
Lihua Sun, Siyan Shi, Weihao Wang, Ying Zhang

Background: Cardiovascular diseases (CVDs) are leading causes of mortality globally, with myocardial ischemia-reperfusion (I/R) injury being a critical challenge in clinical settings. Circular RNAs (circRNAs) have emerged as significant molecular players in various pathophysiological conditions, including myocardial I/R injury.

Objective: This study aimed to investigate the role of circCOL3A1 in myocardial I/R injury and its potential regulatory mechanisms involving miR-29b-3p and MDM2.

Methods: Using a mouse model and H9c2 cardiomyocyte cells, we examined the expression levels of circCOL3A1 under I/R and hypoxia/reoxygenation (H/R) conditions. We utilized RT-qPCR, Western blotting, terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL), and dual-luciferase reporter assays to explore the interaction between circCOL3A1, miR-29b-3p, and MDM2.

Results: CircCOL3A1 was significantly downregulated in both I/R-treated mice and H/R-treated H9c2 cells. Overexpression of circCOL3A1 reduced apoptosis and improved cell viability by modulating the miR-29b-3p/MDM2 axis. These effects were reversed by overexpressing miR-29b-3p or silencing MDM2.

Conclusions: CircCOL3A1 plays a protective role in myocardial I/R injury by acting as a miR-29b-3p sponge, thereby regulating the MDM2-mediated apoptosis pathway. This identifies circCOL3A1 as a potential therapeutic target for treating myocardial I/R injury.

背景:心血管疾病(cvd)是全球死亡的主要原因,心肌缺血再灌注(I/R)损伤是临床环境中的一个关键挑战。环状rna (circRNAs)在包括心肌I/R损伤在内的各种病理生理条件中已成为重要的分子参与者。目的:本研究旨在探讨circol3a1在心肌I/R损伤中的作用及其涉及miR-29b-3p和MDM2的潜在调控机制。方法:采用小鼠模型和H9c2心肌细胞,检测I/R和缺氧/再氧(H/R)条件下circCOL3A1的表达水平。我们利用RT-qPCR、Western blotting、末端脱氧核苷酸转移酶dUTP缺口末端标记(TUNEL)和双荧光素酶报告基因检测来探索circCOL3A1、miR-29b-3p和MDM2之间的相互作用。结果:CircCOL3A1在I/ r处理小鼠和H/ r处理的H9c2细胞中均显著下调。过表达circCOL3A1通过调节miR-29b-3p/MDM2轴减少细胞凋亡,提高细胞活力。这些影响可以通过过表达miR-29b-3p或沉默MDM2来逆转。结论:CircCOL3A1作为miR-29b-3p海绵在心肌I/R损伤中发挥保护作用,从而调控mdm2介导的凋亡通路。这表明circCOL3A1是治疗心肌I/R损伤的潜在治疗靶点。
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引用次数: 0
Place of death from asthma among adults aged 65 and Older, 1999-2023. 1999-2023年65岁及以上成人哮喘死亡地点
IF 1.8 Pub Date : 2025-08-14 DOI: 10.1016/j.amjms.2025.08.011
Guodong Ding, Changgen Li, Angela Vinturache, Yongjun Zhang
{"title":"Place of death from asthma among adults aged 65 and Older, 1999-2023.","authors":"Guodong Ding, Changgen Li, Angela Vinturache, Yongjun Zhang","doi":"10.1016/j.amjms.2025.08.011","DOIUrl":"10.1016/j.amjms.2025.08.011","url":null,"abstract":"","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to "Associations between psoriasis, psoriatic arthritis and gout or hyperuricemia: A systematic review and meta-analysis" [Am J Med Sci. 369 (2025) 671-678]. “银屑病、银屑病关节炎与痛风或高尿酸血症之间的关系:一项系统回顾和荟萃分析”的更正[美国医学杂志]. 369(2025)671-678]。
IF 1.8 Pub Date : 2025-07-21 DOI: 10.1016/j.amjms.2025.07.014
Zixia Liu, Xieli Ma, Tian Chang, Chuanhui Yao, Mengge Song, Shang Biyue, Fuyuan Zhang, Jiameng Liu, Quan Jiang
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引用次数: 0
The closed loop of the circCLIP2/miR-361-3p/STAT2 signaling axis regulates the progression of cervical cancer. circCLIP2/miR-361-3p/STAT2信号轴的闭环调节宫颈癌的进展。
Pub Date : 2024-08-07 DOI: 10.1016/j.amjms.2024.08.002
Qian Zhang, Wang Cai

Background: Circular RNAs (circRNAs) are involved in tumorigenesis and the progression of cancer through various pathways. However, the detailed regulatory mechanisms of circRNAs in cervical cancer are not fully understood. The present study was designed to explore the biological functions and potential mechanisms of circCLIP2 (has_circ_0001717) in cervical cancer.

Methods: The expression profiles of circRNAs in cancerous and adjacent normal tissues of cervical cancer patients were examined using RNA sequencing. Gain- and loss-of-function experiments were carried out to determine the biological functions of circCLIP2 in the proliferation, invasion, migration and apoptosis of cervical cancer cells. qRT-PCR was also used to evaluate the expression of circCLIP2, miR-361-3p and STAT2 in cervical cancer cells. The protein levels of STAT2 were determined by western blotting.

Results: CircCLIP2 was identified as the most down-regulated molecule in the cancerous tissues of cervical cancer patients compared to the adjacent normal tissues. Moreover, the levels of circCLIP2 was decreased in cervical cancer patients with metastasis and advanced tumour stage, and patients with high-circCLIP2-expression exhibited poorer survival rate. In addition, over-expression of circCLIP2 suppressed the proliferation, invasion and migration of cervical cancer cells, whereas cell apoptosis was enhanced. Moreover, down-regulated circCLIP2 functioned as the sponge of miR-361-3p, which reduced the expression of STAT2. Furthermore, knockdown of STAT2 inhibited the expression of circCLIP2 at the transcriptional level.

Conclusion: The circCLIP2/miR-361-3p/STAT2 signalling could mediate the progression of cervical cancer. CircCLIP2 may become a novel target for the diagnosis and treatment of cervical cancer.

背景:环状 RNA(circRNA)通过各种途径参与肿瘤发生和癌症进展。然而,circRNAs 在宫颈癌中的详细调控机制尚未完全明了。本研究旨在探讨 circCLIP2(has_circ_0001717)在宫颈癌中的生物学功能和潜在机制:方法:使用 RNA 测序技术检测了宫颈癌患者癌组织和邻近正常组织中 circRNAs 的表达谱。还采用 qRT-PCR 技术评估 circCLIP2、miR-361-3p 和 STAT2 在宫颈癌细胞中的表达。结果表明:CircCLIP2被鉴定为宫颈癌细胞中最重要的细胞因子:结果:与邻近的正常组织相比,CircCLIP2是宫颈癌患者癌组织中表达下调最多的分子。此外,宫颈癌转移和晚期患者的 circCLIP2 水平降低,高表达的患者生存率较低。此外,circCLIP2 的过度表达抑制了宫颈癌细胞的增殖、侵袭和迁移,同时增强了细胞的凋亡。此外,下调的 circCLIP2 可作为 miR-361-3p 的海绵,减少 STAT2 的表达。此外,STAT2的敲除在转录水平上抑制了circCLIP2的表达:结论:circCLIP2/miR-361-3p/STAT2 信号可介导宫颈癌的进展。CircCLIP2可能成为诊断和治疗宫颈癌的新靶点。
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引用次数: 0
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The American journal of the medical sciences
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