首页 > 最新文献

The American journal of the medical sciences最新文献

英文 中文
Place of death from asthma among adults aged 65 and Older, 1999-2023. 1999-2023年65岁及以上成人哮喘死亡地点
IF 1.8
The American journal of the medical sciences
Pub Date : 2025-08-14 DOI: 10.1016/j.amjms.2025.08.011
Guodong Ding, Changgen Li, Angela Vinturache, Yongjun Zhang
{"title":"Place of death from asthma among adults aged 65 and Older, 1999-2023.","authors":"Guodong Ding, Changgen Li, Angela Vinturache, Yongjun Zhang","doi":"10.1016/j.amjms.2025.08.011","DOIUrl":"10.1016/j.amjms.2025.08.011","url":null,"abstract":"","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to "Associations between psoriasis, psoriatic arthritis and gout or hyperuricemia: A systematic review and meta-analysis" [Am J Med Sci. 369 (2025) 671-678]. “银屑病、银屑病关节炎与痛风或高尿酸血症之间的关系：一项系统回顾和荟萃分析”的更正[美国医学杂志]. 369(2025)671-678]。
IF 1.8
The American journal of the medical sciences
Pub Date : 2025-07-21 DOI: 10.1016/j.amjms.2025.07.014
Zixia Liu, Xieli Ma, Tian Chang, Chuanhui Yao, Mengge Song, Shang Biyue, Fuyuan Zhang, Jiameng Liu, Quan Jiang
{"title":"Corrigendum to \"Associations between psoriasis, psoriatic arthritis and gout or hyperuricemia: A systematic review and meta-analysis\" [Am J Med Sci. 369 (2025) 671-678].","authors":"Zixia Liu, Xieli Ma, Tian Chang, Chuanhui Yao, Mengge Song, Shang Biyue, Fuyuan Zhang, Jiameng Liu, Quan Jiang","doi":"10.1016/j.amjms.2025.07.014","DOIUrl":"10.1016/j.amjms.2025.07.014","url":null,"abstract":"","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The closed loop of the circCLIP2/miR-361-3p/STAT2 signaling axis regulates the progression of cervical cancer. circCLIP2/miR-361-3p/STAT2信号轴的闭环调节宫颈癌的进展。
The American journal of the medical sciences
Pub Date : 2024-08-07 DOI: 10.1016/j.amjms.2024.08.002
Qian Zhang, Wang Cai

Background: Circular RNAs (circRNAs) are involved in tumorigenesis and the progression of cancer through various pathways. However, the detailed regulatory mechanisms of circRNAs in cervical cancer are not fully understood. The present study was designed to explore the biological functions and potential mechanisms of circCLIP2 (has_circ_0001717) in cervical cancer.

Methods: The expression profiles of circRNAs in cancerous and adjacent normal tissues of cervical cancer patients were examined using RNA sequencing. Gain- and loss-of-function experiments were carried out to determine the biological functions of circCLIP2 in the proliferation, invasion, migration and apoptosis of cervical cancer cells. qRT-PCR was also used to evaluate the expression of circCLIP2, miR-361-3p and STAT2 in cervical cancer cells. The protein levels of STAT2 were determined by western blotting.

Results: CircCLIP2 was identified as the most down-regulated molecule in the cancerous tissues of cervical cancer patients compared to the adjacent normal tissues. Moreover, the levels of circCLIP2 was decreased in cervical cancer patients with metastasis and advanced tumour stage, and patients with high-circCLIP2-expression exhibited poorer survival rate. In addition, over-expression of circCLIP2 suppressed the proliferation, invasion and migration of cervical cancer cells, whereas cell apoptosis was enhanced. Moreover, down-regulated circCLIP2 functioned as the sponge of miR-361-3p, which reduced the expression of STAT2. Furthermore, knockdown of STAT2 inhibited the expression of circCLIP2 at the transcriptional level.

Conclusion: The circCLIP2/miR-361-3p/STAT2 signalling could mediate the progression of cervical cancer. CircCLIP2 may become a novel target for the diagnosis and treatment of cervical cancer.

背景：环状 RNA（circRNA）通过各种途径参与肿瘤发生和癌症进展。然而，circRNAs 在宫颈癌中的详细调控机制尚未完全明了。本研究旨在探讨 circCLIP2（has_circ_0001717）在宫颈癌中的生物学功能和潜在机制：方法：使用 RNA 测序技术检测了宫颈癌患者癌组织和邻近正常组织中 circRNAs 的表达谱。还采用 qRT-PCR 技术评估 circCLIP2、miR-361-3p 和 STAT2 在宫颈癌细胞中的表达。结果表明：CircCLIP2被鉴定为宫颈癌细胞中最重要的细胞因子：结果：与邻近的正常组织相比，CircCLIP2是宫颈癌患者癌组织中表达下调最多的分子。此外，宫颈癌转移和晚期患者的 circCLIP2 水平降低，高表达的患者生存率较低。此外，circCLIP2 的过度表达抑制了宫颈癌细胞的增殖、侵袭和迁移，同时增强了细胞的凋亡。此外，下调的 circCLIP2 可作为 miR-361-3p 的海绵，减少 STAT2 的表达。此外，STAT2的敲除在转录水平上抑制了circCLIP2的表达：结论：circCLIP2/miR-361-3p/STAT2 信号可介导宫颈癌的进展。CircCLIP2可能成为诊断和治疗宫颈癌的新靶点。
{"title":"The closed loop of the circCLIP2/miR-361-3p/STAT2 signaling axis regulates the progression of cervical cancer.","authors":"Qian Zhang, Wang Cai","doi":"10.1016/j.amjms.2024.08.002","DOIUrl":"https://doi.org/10.1016/j.amjms.2024.08.002","url":null,"abstract":"<p><strong>Background: </strong>Circular RNAs (circRNAs) are involved in tumorigenesis and the progression of cancer through various pathways. However, the detailed regulatory mechanisms of circRNAs in cervical cancer are not fully understood. The present study was designed to explore the biological functions and potential mechanisms of circCLIP2 (has_circ_0001717) in cervical cancer.</p><p><strong>Methods: </strong>The expression profiles of circRNAs in cancerous and adjacent normal tissues of cervical cancer patients were examined using RNA sequencing. Gain- and loss-of-function experiments were carried out to determine the biological functions of circCLIP2 in the proliferation, invasion, migration and apoptosis of cervical cancer cells. qRT-PCR was also used to evaluate the expression of circCLIP2, miR-361-3p and STAT2 in cervical cancer cells. The protein levels of STAT2 were determined by western blotting.</p><p><strong>Results: </strong>CircCLIP2 was identified as the most down-regulated molecule in the cancerous tissues of cervical cancer patients compared to the adjacent normal tissues. Moreover, the levels of circCLIP2 was decreased in cervical cancer patients with metastasis and advanced tumour stage, and patients with high-circCLIP2-expression exhibited poorer survival rate. In addition, over-expression of circCLIP2 suppressed the proliferation, invasion and migration of cervical cancer cells, whereas cell apoptosis was enhanced. Moreover, down-regulated circCLIP2 functioned as the sponge of miR-361-3p, which reduced the expression of STAT2. Furthermore, knockdown of STAT2 inhibited the expression of circCLIP2 at the transcriptional level.</p><p><strong>Conclusion: </strong>The circCLIP2/miR-361-3p/STAT2 signalling could mediate the progression of cervical cancer. CircCLIP2 may become a novel target for the diagnosis and treatment of cervical cancer.</p>","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association Between Neck Circumference and Bone Mineral Loss: A Cross-sectional Study in Sichuan Province in China. 颈围与骨矿物质流失的关系：一项在中国四川省进行的横断面研究。
The American journal of the medical sciences
Pub Date : 2024-05-01 DOI: 10.1016/j.amjms.2024.05.004
Qing Wen, Xiaoran Zhang, Yunjiao Yang, Huizhen Chen, Xuke Han, Qiu Chen
{"title":"Association Between Neck Circumference and Bone Mineral Loss: A Cross-sectional Study in Sichuan Province in China.","authors":"Qing Wen, Xiaoran Zhang, Yunjiao Yang, Huizhen Chen, Xuke Han, Qiu Chen","doi":"10.1016/j.amjms.2024.05.004","DOIUrl":"https://doi.org/10.1016/j.amjms.2024.05.004","url":null,"abstract":"","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":"28 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141023966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing AI-driven tools as a method for cardiopulmonary resuscitation for non-healthcare workers 评估将人工智能驱动工具作为非医护人员心肺复苏方法的情况
The American journal of the medical sciences
Pub Date : 2024-02-08 DOI: 10.1016/s0002-9629(24)00610-4
M Al Akeel, SN Notta, L AlHuneafat, A Hashem, M Jbara
{"title":"Assessing AI-driven tools as a method for cardiopulmonary resuscitation for non-healthcare workers","authors":"M Al Akeel, SN Notta, L AlHuneafat, A Hashem, M Jbara","doi":"10.1016/s0002-9629(24)00610-4","DOIUrl":"https://doi.org/10.1016/s0002-9629(24)00610-4","url":null,"abstract":"","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139921352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An unsual case of a positive lupus anticoagulant loculated pericardial and pleural effusion 狼疮抗凝剂阳性定位心包和胸腔积液的罕见病例
The American journal of the medical sciences
Pub Date : 2024-02-08 DOI: 10.1016/s0002-9629(24)00205-2
S Ali, H Assi, O Aboudawoud, S Chaudhry, C Vu, S Prakash, M Hassan, S Nadella, MA Cazares Parson, M Rondla, JJ Bies, M Porres-Aguilar
{"title":"An unsual case of a positive lupus anticoagulant loculated pericardial and pleural effusion","authors":"S Ali, H Assi, O Aboudawoud, S Chaudhry, C Vu, S Prakash, M Hassan, S Nadella, MA Cazares Parson, M Rondla, JJ Bies, M Porres-Aguilar","doi":"10.1016/s0002-9629(24)00205-2","DOIUrl":"https://doi.org/10.1016/s0002-9629(24)00205-2","url":null,"abstract":"","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139921423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Left Ventricular Assist Device (LVAD) implantations in children in the United States; a 5 year analysis from the National Inpatient Sample 美国儿童左心室辅助装置（LVAD）植入情况；全国住院病人抽样五年分析
The American journal of the medical sciences
Pub Date : 2024-02-01 DOI: 10.1016/s0002-9629(24)00209-x
M. Almasri, A. F. I. Masri, R. Dachepally
{"title":"Left Ventricular Assist Device (LVAD) implantations in children in the United States; a 5 year analysis from the National Inpatient Sample","authors":"M. Almasri, A. F. I. Masri, R. Dachepally","doi":"10.1016/s0002-9629(24)00209-x","DOIUrl":"https://doi.org/10.1016/s0002-9629(24)00209-x","url":null,"abstract":"","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":"11 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139873637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimizing Hepatitis B screening strategies in the pediatric population: addressing non-responders and waning antibody levels 优化儿科人群的乙肝筛查策略：解决无应答者和抗体水平下降问题
The American journal of the medical sciences
Pub Date : 2024-02-01 DOI: 10.1016/s0002-9629(24)00590-1
C. Yost, FJ Whitaker, D. Mills, K. Duvall
{"title":"Optimizing Hepatitis B screening strategies in the pediatric population: addressing non-responders and waning antibody levels","authors":"C. Yost, FJ Whitaker, D. Mills, K. Duvall","doi":"10.1016/s0002-9629(24)00590-1","DOIUrl":"https://doi.org/10.1016/s0002-9629(24)00590-1","url":null,"abstract":"","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":"13 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139873729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of race on renal recovery in patients with new diagnosis of multiple myeloma and acute kidney injury requiring dialysis 种族对新诊断为多发性骨髓瘤且急性肾损伤需要透析的患者肾功能恢复的影响
The American journal of the medical sciences
Pub Date : 2024-02-01 DOI: 10.1016/s0002-9629(24)00685-2
S. Kanduri, D. Patel, K. Kovvuru, J. Velez
{"title":"Impact of race on renal recovery in patients with new diagnosis of multiple myeloma and acute kidney injury requiring dialysis","authors":"S. Kanduri, D. Patel, K. Kovvuru, J. Velez","doi":"10.1016/s0002-9629(24)00685-2","DOIUrl":"https://doi.org/10.1016/s0002-9629(24)00685-2","url":null,"abstract":"","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":"187 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139877593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hypertensive medication use in patients with hypertrophic cardiomyopathy 肥厚型心肌病患者的降压药物使用情况
The American journal of the medical sciences
Pub Date : 2024-02-01 DOI: 10.1016/s0002-9629(24)00604-9
HP Mace, N. Foxworth, A. Rizwan, A. Hamid, WF Campbell, MR McMullan, M. Hall
{"title":"Hypertensive medication use in patients with hypertrophic cardiomyopathy","authors":"HP Mace, N. Foxworth, A. Rizwan, A. Hamid, WF Campbell, MR McMullan, M. Hall","doi":"10.1016/s0002-9629(24)00604-9","DOIUrl":"https://doi.org/10.1016/s0002-9629(24)00604-9","url":null,"abstract":"","PeriodicalId":94223,"journal":{"name":"The American journal of the medical sciences","volume":"8 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139878556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
类型
全部 化学•材料 生命科学 医学 物理 工程技术 环境•农林 材料科学 地球科学 法学 管理学 化学 环境科学与生态学 计算机科学 教育学 经济学 农林科学 人文科学 生物学 数学 物理与天体物理 心理学 综合性期刊 其他 工业工程 理学 历史学 农学 文学 信息工程
数据库
全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley
期刊
The American journal of the medical sciences
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
﹀
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们：info@booksci.cn
Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1