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Decision Tree for Reconstructive Treatment of Peri-implantitis Defects. 种植体周围炎缺陷修复治疗决策树
Pub Date : 2025-07-11 DOI: 10.11607/prd.7205
Istvan A Urban, Zhaozhao Chen, Hom-Lay Wang

Peri-implantitis is a common complication among patients receiving implant-supported restorative therapy, and it often requires surgical intervention for effective treatment. Understanding the specific configuration of the peri-implant bony defect and adjacent bone peaks is crucial for tailoring treatment strategies and improving outcomes. A decision tree for reconstructive peri-implantitis therapy has been developed based on the new classification of defect configurations (Classes I to V), guiding clinicians in selecting treatment options, including biomaterials, techniques, and healing approaches. Furthermore, clinicians are encouraged to consider various factors such as local predisposing factors (including soft tissue characteristics, prosthetic design, and implant position in a 3D perspective), clinical factors (surgeon skill and experience), and patient-related factors (such as local and systemic health, preferences, and cost) when evaluating reconstructive therapy options.

种植体周围炎是接受种植体支持修复治疗的患者中常见的并发症,通常需要手术干预才能有效治疗。了解种植体周围骨缺损和邻近骨峰的具体结构对于制定治疗策略和提高疗效至关重要。根据新的缺损结构分类(I 级至 V 级),我们开发了种植体周围炎修复治疗决策树,指导临床医生选择治疗方案,包括生物材料、技术和愈合方法。此外,还鼓励临床医生在评估重建治疗方案时考虑各种因素,如局部易感因素(如软组织特征、修复体设计和三维视角下的种植体位置)、临床因素(外科医生的技术和经验)以及患者相关因素(如局部和全身健康状况、偏好和费用)。
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引用次数: 0
Polynucleotides and Hyaluronic Acid Mixture with Volume Stable Collagen Matrix for Coverage of Multiple Gingival Recession: A Case Series. 多核苷酸和透明质酸混合物与体积稳定的胶原基质覆盖多重牙龈退缩:一个病例系列。
Pub Date : 2025-07-11 DOI: 10.11607/prd.7687
Daniele Cardaropoli, Alessandro Roffredo, Lorenzo Tamagnone, Lorena Gaveglio, Mauricio Araujo

Multiple adjacent gingival recessions are a challenge to the practitioner. Although the gold standard is still the bilaminar technique, where a coronally advanced flap (CAF) is associated with autogenous connective tissue graft (CTG), the morbidity of the procedure may lead clinicians to look for CTG substitutes. In this study, a prospective case series, 16 patients presenting multiple adjacent gingival recession were treated using CAF plus a volume stable collagen matrix (VXCM) soaked with a gel made of polynucleotides and hyaluronic acid (PNHA). Clinical measurements (probing depth, recession, attachment level, keratinised mucosa) were performed at baseline (T0), six months (T1) and twelve months (T2) post-operatively. Change in gingival thickness (dGT) was also measured using intraolar scans at T0 and T2, together with secondary variables, such as wound healing indices, patient-reported outcomes (pain, esthetics), and adverse events. Statistical analysis has been performed, setting significance with p<0.05. At one year evaluation, mean recession depth decreased of 2.42 ± 0.45, the percentage of root coverage was 96.02 + 0.09% (80.59% complete root coverage) , while gingival thickness dGT increased by 1.14 ± 0.34 mm, indicating that VXCM and PN-HA plus CAF are a suitable option for the treatment of multiple adjacent gingival recessions.

多个相邻的牙龈衰退是一个挑战,从业者。尽管双层技术仍然是金标准,其中冠状晚期皮瓣(CAF)与自体结缔组织移植(CTG)相关,但该手术的发病率可能导致临床医生寻找CTG替代品。在本研究中,一个前瞻性的病例系列,16例患者出现多邻近牙龈萎缩,使用CAF加体积稳定的胶原基质(VXCM)浸泡的凝胶由多核苷酸和透明质酸(PNHA)。在术后基线(T0)、6个月(T1)和12个月(T2)进行临床测量(探探深度、退行、附着水平、角化粘膜)。在T0和T2时,还使用牙内扫描测量牙龈厚度(dGT)的变化,以及次要变量,如伤口愈合指数、患者报告的结果(疼痛、美学)和不良事件。进行了统计学分析,以p
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引用次数: 0
Miller's Classification of Marginal Tissue Recession: 40 Years of a Game Changer. 米勒的边缘组织衰退分类:改变游戏规则的40年。
Pub Date : 2025-07-11 DOI: 10.11607/prd.2025.4.e
Leandro Chambrone, Gustavo Avila-Ortiz
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引用次数: 0
Surgical Strategies for Implantation in Cases of Large Incisive Foramen: A Pilot Case Series Study. 大切口孔植入的手术策略:一项试点病例系列研究。
Pub Date : 2025-07-11 DOI: 10.11607/prd.7376
José Carlos Martins da Rosa, Ariádene Cristina Pértile de Oliveira Rosa, Istvan Urban

This case series was aimed primarily at evaluating the outcomes of a reconstructive technique employing autogenous bone grafting using maxillary tuberosity (MT) donor sites for the management of extraction sockets adjacent to large incisive foramena (IFs) in the anterior maxillary region, with the purpose of addressing challenges associated with implant placement. In this series of four cases, we applied a reconstructive technique utilizing autogenous bone grafting using MT donor sites. Patients underwent a postoperative maintenance program, clinical examinations, and completion of a questionnaire to assess changes in the neurosensory function of the nasopalatine nerve. Study outcomes included the extent of bone reconstruction, postoperative neurosensory function of the nasopalatine nerve, and overall patient satisfaction. Cases were followed for a mean of 23.5±0.5 months. The technique consistently resulted in predictable bone reconstruction, either with delayed or immediate implantation and provisionalization. IF enucleation and reconstruction of the damaged extraction sockets resulted in no abnormal postoperative pain or paresthesia, and yielded high patient satisfaction. The use of autogenous bone grafts from the MT provides an optimal and simple solution for the management of extraction sockets adjacent to large IFs. Our findings illustrate the potential efficacy of this technique in complex scenarios associated with high esthetic implications, which should be further evaluated in future clinical trials.

本病例系列的主要目的是评估利用上颌结节(MT)供体部位自体骨移植重建技术的结果,以解决上颌前区大切口孔(IFs)附近拔牙窝的问题,并解决与种植体放置相关的挑战。在这四个病例中,我们采用了自体骨移植的重建技术。患者接受术后维持计划、临床检查,并完成一份评估鼻腭神经神经感觉功能变化的问卷。研究结果包括骨重建的程度、术后鼻腭神经的神经感觉功能和患者的总体满意度。平均随访23.5±0.5个月。该技术始终导致可预测的骨重建,无论是延迟或立即植入和预备。中脑摘除并重建受损的拔牙窝,术后无异常疼痛或感觉异常,患者满意度高。使用MT的自体骨移植物为管理大型if附近的拔牙槽提供了一个最佳和简单的解决方案。我们的研究结果说明了这种技术在与高审美影响相关的复杂情况下的潜在功效,这应该在未来的临床试验中进一步评估。
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引用次数: 0
Intentional Replantation in Combination with Fibroblast Growth Factor-2 Application and Orthodontic Tooth Extrusion for Periodontal Regeneration in the Treatment of Severe Endodontic-Periodontal Lesions. 应用成纤维细胞生长因子-2 和正畸牙拔出治疗严重牙髓牙周病变中的牙周再生时的意向性种植。
Pub Date : 2025-07-11 DOI: 10.11607/prd.6996
Noboru Katayama, Daisuke Ueno, Chihiro Masaki, Tomohiro Ishikawa

Endodontic-periodontal lesions are characterized by the involvement of the pulp and periodontal disease in the same tooth. Despite successful root canal treatment, if the majority of bone support has been lost from periodontitis, the tooth may have a poor prognosis. In severe endodonticperiodontal lesions, the periodontal tissue regenerates poorly because of the significant loss of the periodontal ligament and cementum, poor tooth stability, and bone defect morphology that is unfavorable for bone regeneration. To overcome these difficult situations, osteotomy of the replantation bed and tooth replantation with horizontal rotation and deep placement may be performed. In the presented case, in order to improve periodontal regeneration, fibroblast growth factor-2 (FGF2) was applied to the artificially made periodontal defect. In addition, orthodontic extrusion of the deeply replaced tooth was performed for potential coronal migration of the periodontal tissue. This case presents a unique multidisciplinary method of treating severe endodontic-periodontal lesions using intentional replantation combined with FGF2 application and orthodontic extrusion.

牙髓牙周病变的特点是牙髓和牙周病在同一颗牙齿上受累。尽管根管治疗很成功,但如果牙周炎导致大部分牙槽骨支持丧失,牙齿的预后可能很差。在严重的牙髓牙周病变中,由于牙周韧带和骨水泥的大量丧失、牙齿稳定性差以及骨缺损形态不利于骨再生,牙周组织的再生能力很差。为了克服这些困难,在本病例中,对再植床进行了截骨手术,并进行了水平旋转和深嵌体的牙齿再植。为了改善牙周再生,在人工制作的牙周缺损处应用了成纤维细胞生长因子(FGF)2。此外,还对深度替换的牙齿进行了正畸挤压,以防止牙周组织发生冠状移位。本病例展示了一种独特的多学科方法,即通过有意再植结合应用 FGF 2 和正畸挤压来治疗严重的牙髓牙周病变。
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引用次数: 0
Artificial Intelligence to Advance Precision Oral Health. 人工智能促进口腔精准健康。
Pub Date : 2025-07-11 DOI: 10.11607/prd.7762
William V Giannobile
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引用次数: 0
Implant Stability Quotient and Bone-to-Implant Contact Analyses of Immediately Placed Implants in Human Cadavers. 植体稳定性商数及骨与植体接触分析。
Pub Date : 2025-07-11 DOI: 10.11607/prd.7624
Jae W Chang, Jiarui Bi, Seiko Min, Nadine Gräfin von Krockow, Paul Weigl

Background: Immediate implant placement has become increasingly prevalent in clinical practice, and accurate assessment of placement quality is crucial to ensure successful outcomes. Bone-to-implant contact (BIC) is one of the critical determinants of primary stability following implantation. However, its correlation to the implant stability quotient (ISQ) is uncertain. This study aims to determine the relationship between ISQ measurements and BIC in immediately placed implants.

Materials and methods: An atraumatic extraction followed by immediate implant placements were performed on 33 teeth in seven human cadaver heads. The implant ISQ values were measured in four directions: buccal, lingual, mesial, and distal. The cadaver heads were imaged using cone-beam computed tomography (CBCT) to determine the linear BICs in the corresponding directions.

Results: Among the twenty-eight implants analyzed, no correlations were observed between directional BICs and the corresponding ISQ values. ISQ measurements did not significantly differ between maxillary and mandibular implants, nor among different anatomical locations. Additionally, when solid contact was present at the implant shoulder, the ISQ values remained stable despite the absence of apical BIC.

Conclusion: ISQ values alone appear to be poor predictors of BIC in immediately placed implants. Therefore, ISQ measurements should be interpreted alongside other assessment methods to more accurately evaluate implant stability.

背景:即刻种植体置入术在临床实践中越来越普遍,准确评估置入术质量是确保成功的关键。骨-种植体接触(BIC)是种植后初级稳定性的关键决定因素之一。然而,其与种植体稳定商(ISQ)的相关性尚不确定。本研究旨在确定即刻植入物中ISQ测量与BIC之间的关系。材料和方法:对7具尸体头部的33颗牙齿进行了无伤性拔牙并立即植入。种植体ISQ值在四个方向测量:颊、舌、中、远端。使用锥形束计算机断层扫描(CBCT)对尸体头部进行成像,以确定相应方向上的线性bic。结果:在分析的28个种植体中,没有观察到定向bic与相应的ISQ值之间的相关性。ISQ测量在上颌和下颌种植体之间没有显著差异,在不同的解剖位置之间也没有显著差异。此外,当植入体肩部存在固体接触时,尽管没有根尖BIC, ISQ值仍保持稳定。结论:单独的ISQ值似乎不能很好地预测即刻植入体的BIC。因此,ISQ测量应与其他评估方法一起解释,以更准确地评估种植体的稳定性。
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引用次数: 0
Key Clinical Considerations for Intraoral Harvesting of Deepithelialized Free Masticatory Mucosal Grafts: A Narrative Review. 口腔内摘取游离咀嚼黏膜深度上皮移植物的关键临床考虑:叙述性回顾。
Pub Date : 2025-07-11 DOI: 10.11607/prd.7783
Lory Abrahamian, Álvaro Babiano, Gustavo Avila-Ortiz, José Nart, Gonzalo Blasi

Autogenous grafts are broadly regarded as the gold standard material for soft tissue augmentation in periodontal and implant-related surgery. However, intraoral harvesting of autogenous soft tissue grafts can pose challenges for clinicians due to technical complexity, limited available tissue, and the potential for patient morbidity, among other reasons. This comprehensive review explores key aspects of autogenous connective tissue graft harvesting with a particular focus on approaches involving the de-epithelialization of free masticatory mucosal grafts (DFMMGs), such as the main advantages and disadvantages of extra- and intraoral de-epithelialization, emerging technologies to assist and streamline harvesting, donor site healing dynamics, postoperative pain perception, wound management strategies, and common intra- and postoperative complications.

自体移植物被广泛认为是牙周和种植相关手术中软组织增强的金标准材料。然而,由于技术复杂性、可用组织有限以及患者发病的可能性等原因,口腔内采集自体软组织移植物给临床医生带来了挑战。这篇综述探讨了自体结缔组织移植收获的关键方面,特别关注游离咀嚼粘膜移植(DFMMGs)的脱上皮化方法,如口腔外和口腔内脱上皮化的主要优点和缺点,辅助和简化收获的新兴技术,供体部位愈合动态,术后疼痛感知,伤口管理策略,以及常见的手术内和术后并发症。
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引用次数: 0
Do Intrabony Defects Have a Worse Clinical Response to Step 2 of Periodontal Therapy and Repeated Subgingival Instrumentation Compared to Suprabony Defects? A Systematic Review. 与骨上缺陷相比,骨内缺陷对牙周治疗第二步和重复龈下器械操作的临床反应更差?系统回顾。
Pub Date : 2025-07-11 DOI: 10.11607/prd.7235
Lorenzo Marini, Alessandro Cuozzo, Giuseppe Mainas, Georgios Antonoglou, Andrea Pilloni, Luigi Nibali

This study aimed to assess the differential clinical response to step 2 of periodontal therapy and repeated subgingival instrumentation between teeth with suprabony and intrabony defects. Electronic and manual searches were performed to identify studies reporting the differential clinical outcomes of nonsurgical periodontal therapy (NSPT) in the presence or absence of intrabony defects. The Cochrane Risk of Bias 2 and the Newcastle-Ottawa scale were used to assess the risk of bias. A total of 2,348 articles were initially screened, and a total of 5 articles were finally included. Regarding the primary outcome measure, two studies reported probing pocket depth (PPD) reductions at 6 months after step 2 of periodontal therapy, showing an opposite response of intrabony defects compared to suprabony defects (3.2 ± 1.9 mm intrabony vs 2.2 ± 1.7 mm suprabony in one study, and 0.48 ± 0.42 mm intrabony vs 0.72 ± 0.36 mm suprabony in the other), while one study reported no differences at 3 months. One study showed a negative association between the presence of an intrabony defect and PPD reduction at 9 months after nonsurgical step 3 (P < .05). Due to the limited number of studies and heterogeneity of the data, conflicting evidence emerged for the differential response to NSPT of intrabony and suprabony defects.

目的:评估有龈上缺损和龈内缺损的牙齿对牙周治疗第二步和重复龈下器械治疗的不同临床反应:采用电子和人工检索的方式,确定报告非手术牙周治疗(NSPT)在有无牙槽骨内缺损情况下的不同临床效果的研究。采用 Cochrane Risk of Bias 2 和 Newcastle Ottawa 量表评估偏倚风险:初步筛选了 2348 篇文章,最终共纳入 5 篇文章。关于主要结果指标,有两项研究报告了牙周治疗第二步后 6 个月的 PPD 减少值,显示牙内缺损与牙上缺损的反应相反(分别为 3.2 mm ± 1.9 对 2.2 mm ± 1.7 和 0.48 mm ± 0.42 对 0.72 mm ± 0.36),而一项研究报告 3 个月时没有差异。一项研究显示,在非手术步骤 3 后的 9 个月,骨内缺损的存在与 PPD 的减少呈负相关(P < 0.05):结论:由于研究数量有限以及数据的异质性,关于骨内和骨上缺损对 NSPT 的不同反应出现了相互矛盾的证据。
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引用次数: 0
Collagen Matrix for Increasing Peri-implant Mucosal Thickness in Smokers: A Prospective Case Series. 用于增加吸烟者种植体周围黏膜厚度的胶原蛋白基质:前瞻性病例系列
Pub Date : 2025-07-11 DOI: 10.11607/prd.7253
Isabella Neme Ribeiro Dos Reis, Luiza Orsi Caminha Sant'Anna, Marcos Hayashi, Nilson Galdeano, Daiane Cristina Peruzzo, Franz Josef Strauss, Claudio Mendes Pannuti

This prospective case series aimed to evaluate the feasibility of using a volume collagen matrix for soft tissue augmentation to increase mucosal thickness in single implants in smokers who consume more than 10 cigarettes per day. Participants had single submerged implants necessitating soft tissue thickening. Soft tissue augmentation was done using a collagen matrix in the second-stage surgery. The primary outcome was soft tissue thickness at 90 days post-surgery. Secondary outcomes included median thickness at 30 and 60 days, changes in buccal soft tissue profile (digital measurements) at 30, 60, and 90 days, and oral health-related quality of life using OHIP-14 up to 90 days post-surgery. Pain levels via VAS scale and adverse effects were also assessed. Ten participants (4 men, 6 women) aged 45.2 ± 13.18 years initially smoked 10-20 cigarettes daily (average: 14.70 ± 3.47 cigarettes/day). After 90 days, median soft tissue thickness increased to 3.00 (2.00;3.00) mm. Buccal soft tissue profile (median change in ROI) increased by 0.40 (0.25;0.62) mm at 90 days. Pain levels decreased, and oral health-related quality of life improved significantly. No complications were reported. The collagen matrix significantly augmented buccal soft tissue thickness at implant sites in smokers (>10 cigarettes/day), with favorable outcomes and no complications.

这项前瞻性病例系列研究旨在评估使用体积胶原蛋白基质进行软组织增厚的可行性,以增加每天吸烟超过 10 支的吸烟者单个种植体的粘膜厚度。受试者的植入物为单个浸没式植入物,需要进行软组织增厚。在第二阶段手术中使用胶原蛋白基质进行软组织增厚。主要结果是术后 90 天的软组织厚度。次要结果包括术后 30 天和 60 天的中位厚度、术后 30 天、60 天和 90 天的口腔软组织外形变化(数字测量),以及术后 90 天内使用 OHIP-14 进行的口腔健康相关生活质量评估。此外,还通过 VAS 量表对疼痛程度和不良反应进行了评估。10 名参与者(4 名男性,6 名女性)的年龄为 45.2 ± 13.18 岁,最初每天吸烟 10-20 支(平均:14.70 ± 3.47 支/天)。90 天后,软组织厚度中值增至 3.00 (2.00;3.00) 毫米。90 天后,颊软组织轮廓(ROI 变化中位数)增加了 0.40 (0.25;0.62) 毫米。疼痛程度减轻,与口腔健康相关的生活质量明显改善。无并发症报告。胶原蛋白基质能明显增加吸烟者(每天吸烟超过 10 支)种植部位的颊软组织厚度,效果良好,无并发症。
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引用次数: 0
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The International journal of periodontics & restorative dentistry
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