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Autosomal Dominant Lamellar Ichthyosis Keeps Surprising Us. 常染色体显性片状鱼鳞病不断给我们带来惊喜。
Pub Date : 2024-12-01 Epub Date: 2024-07-11 DOI: 10.1016/j.jid.2024.05.008
Heiko Traupe
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引用次数: 0
Desmosomal Hyper-Adhesion Affects Direct Inhibition of Desmoglein Interactions in Pemphigus. 在丘疹性荨麻疹中,脱丝体过度粘附会影响对脱丝蛋白相互作用的直接抑制。
Pub Date : 2024-12-01 Epub Date: 2024-04-26 DOI: 10.1016/j.jid.2024.03.042
Letyfee Steinert, Michael Fuchs, Anna M Sigmund, Dario Didona, Christoph Hudemann, Christian Möbs, Michael Hertl, Takashi Hashimoto, Jens Waschke, Franziska Vielmuth

During differentiation, keratinocytes acquire a strong, hyper-adhesive state, where desmosomal cadherins interact calcium ion independently. Previous data indicate that hyper-adhesion protects keratinocytes from pemphigus vulgaris autoantibody-induced loss of intercellular adhesion, although the underlying mechanism remains to be elucidated. Thus, in this study, we investigated the effect of hyper-adhesion on pemphigus vulgaris autoantibody-induced direct inhibition of desmoglein (DSG) 3 interactions by atomic force microscopy. Hyper-adhesion abolished loss of intercellular adhesion and corresponding morphological changes of all pathogenic antibodies used. Pemphigus autoantibodies putatively targeting several parts of the DSG3 extracellular domain and 2G4, targeting a membrane-proximal domain of DSG3, induced direct inhibition of DSG3 interactions only in non-hyper-adhesive keratinocytes. In contrast, AK23, targeting the N-terminal extracellular domain 1 of DSG3, caused direct inhibition under both adhesive states. However, antibody binding to desmosomal cadherins was not different between the distinct pathogenic antibodies used and was not changed during acquisition of hyper-adhesion. In addition, heterophilic DSC3-DSG3 and DSG2-DSG3 interactions did not cause reduced susceptibility to direct inhibition under hyper-adhesive condition in wild-type keratinocytes. Taken together, the data suggest that hyper-adhesion reduces susceptibility to autoantibody-induced direct inhibition in dependency on autoantibody-targeted extracellular domain but also demonstrate that further mechanisms are required for the protective effect of desmosomal hyper-adhesion in pemphigus vulgaris.

在分化过程中,角朊细胞会获得一种强大的超粘附状态,在这种状态下,脱膜粘附蛋白的相互作用与 Ca2+ 无关。以前的数据表明,超粘附能保护角质形成细胞免受天疱疮自身抗体(PV-IgG)诱导的细胞间粘附力丧失的影响,但其基本机制仍有待阐明。因此,我们在此通过原子力显微镜研究了超粘附对 PV-IgG 诱导的直接抑制去疱疹素(Dsg)3 相互作用的影响。超粘附消除了细胞间粘附的丧失以及所有致病抗体的相应形态学变化。丘疹性荨麻疹自身抗体假定靶向Dsg3胞外结构域(ECD)的几个部分,而2G4则靶向Dsg3的膜近端结构域,这两种抗体只在非超粘附角质形成细胞中直接抑制Dsg3的相互作用。相反,靶向 Dsg3 N 端 ECD1 的 AK23 在两种粘附状态下都能直接抑制 Dsg3 的相互作用。然而,不同的致病抗体与脱丝体粘附蛋白的结合并无不同,在获得超粘附时也没有变化。此外,嗜异性的 Dsc3-Dsg3 和 Dsg2-Dsg3 相互作用不会导致 wt 角质细胞在高粘附状态下对直接抑制的敏感性降低。总之,这些数据表明,在依赖自身抗体靶向 ECD 的情况下,超粘附会降低对自身抗体诱导的直接抑制的敏感性,但同时也表明,脱粘体超粘附在 PV 中的保护作用还需要进一步的机制。
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引用次数: 0
Keratinocytes Listen, Respond, and Actively Contribute to Crosstalk in the Epidermal Community and Beyond. 角质形成细胞倾听、回应并积极促进表皮群落内外的串联。
Pub Date : 2024-12-01 Epub Date: 2024-07-09 DOI: 10.1016/j.jid.2024.03.045
Sara J Brown
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引用次数: 0
Genetic Study of Psoriasis Highlights its Close Link with Socioeconomic Status and Affective Symptoms. 对银屑病的遗传研究突出表明,银屑病与社会经济地位和情感症状密切相关。
Pub Date : 2024-12-01 Epub Date: 2024-05-18 DOI: 10.1016/j.jid.2024.03.043
Anni Heikkilä, Eeva Sliz, Laura Huilaja, Kadri Reis, Priit Palta, Abdelrahman G Elnahas, Anu Reigo, Tõnu Esko, Triin Laisk, Maris Teder-Laving, Kaisa Tasanen, Johannes Kettunen

Psoriasis is an inflammatory skin disease with an estimated heritability of around 70%. Previous GWASs have detected several risk loci for psoriasis. To further improve the understanding of the genetic risk factors impacting the disease, we conducted a discovery GWAS in FinnGen and a subsequent replication and meta-analysis with data from the Estonian Biobank and the UK Biobank; the study sample included 925,649 individuals (22,659 cases and 902,990 controls), the largest sample for psoriasis yet. In addition, we conducted downstream analyses to find out more about psoriasis' cross-trait genetic correlations and causal relationships. We report 6 risk loci, which, to our knowledge, are previously unreported, most of which harbor genes related to NF-κB signaling pathway and overall immunity. Genetic correlations highlight the relationship between psoriasis and smoking, higher body weight, and lower education level. In addition, we report causal relationships between psoriasis and mood symptoms as well as 2-directioned causal relationship between psoriasis and lower education level. Our results provide further knowledge on psoriasis risk factors, which may be useful in the development of future treatment strategies.

银屑病是一种炎症性皮肤病,估计遗传率约为 70%。以往的全基因组关联研究(GWAS)发现了几个银屑病的风险基因位点。为了进一步了解影响该疾病的遗传风险因素,我们在芬兰基因组中进行了发现性全基因组关联研究,随后利用爱沙尼亚生物库和英国生物库的数据进行了复制和荟萃分析;研究样本包括 925 649 人(22 659 例病例和 902 990 例对照),是迄今为止最大的银屑病样本。此外,我们还进行了下游分析,以进一步了解银屑病的跨性状遗传相关性和因果关系。据我们所知,我们报告了 6 个以前从未报告过的风险基因位点,其中大部分基因与活化 B 细胞信号通路的核因子卡巴轻链增强子和整体免疫有关。遗传相关性突显了银屑病与吸烟、较高体重和较低教育水平之间的关系。此外,我们还报告了银屑病与情绪症状之间的因果关系,以及银屑病与较低教育水平之间的双向因果关系。我们的研究结果提供了有关银屑病风险因素的更多知识,这可能有助于未来治疗策略的制定。
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引用次数: 0
Mystery of Melanotransferrin in Melanoma. 黑色素瘤中黑色素转铁蛋白的奥秘。
Pub Date : 2024-12-01 Epub Date: 2024-09-14 DOI: 10.1016/j.jid.2024.07.024
Gagan Chhabra, Nihal Ahmad
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引用次数: 0
Psoriasis: Disease Modification Today, Cure Tomorrow. 牛皮癣:今天改变疾病,明天治愈疾病。
Pub Date : 2024-12-01 Epub Date: 2024-10-24 DOI: 10.1016/j.jid.2024.10.004
Joel M Gelfand
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引用次数: 0
Essential Role of Macrophages in Contact Hypersensitivity-Induced Hair Regeneration. 巨噬细胞在接触过敏诱导的毛发再生中发挥着重要作用。
Pub Date : 2024-12-01 Epub Date: 2024-06-25 DOI: 10.1016/j.jid.2024.05.022
Kai-Rong Huang, Sabrina Mai-Yi Fan, Kang-Yu Tai, Jian-Da Lin, Che-Feng Chang, Kai-Chien Yang, Sung-Jan Lin
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引用次数: 0
SERPINB3/B4 Is Increased in Psoriasis and Rosacea Lesions and Has Proinflammatory Effects in Mouse Models of these Diseases. 银屑病和红斑痤疮皮损中的 SERPINB3/B4 增加,并在这些疾病的小鼠模型中具有促炎作用。
Pub Date : 2024-12-01 Epub Date: 2024-05-10 DOI: 10.1016/j.jid.2024.04.011
Wenqin Xiao, Ke Sha, Mei Wang, Zixin Tan, Yunying Wang, San Xu, Zhixiang Zhao, Qian Wang, Hongfu Xie, Mengting Chen, Zhili Deng, Ji Li

Psoriasis and rosacea are both chronic inflammatory skin disorders resulted from aberrant keratinocyte-immune cell crosstalk, but the common molecular foundations for these 2 conditions are poorly understood. In this study, we reveal that both patients with psoriasis and those with rosacea as well as their mouse models have significantly elevated expressions of SERPINB3/B4 (members of serine protease inhibitor) in the lesional skin. Skin inflammation in mice that resembles both psoriasis and rosacea is prevented by SERPINB3/B4 deficiency. Mechanistically, we demonstrate that SERPINB3/B4 positively induces NF-κB signaling activation, thereby stimulating disease-characteristic inflammatory chemokines and cytokines production in keratinocytes and promoting the chemotaxis of CD4+ T cells. Our results suggest that in keratinocytes, SERPINB3/B4 may be involved in the pathogenesis of both psoriasis and rosacea by stimulating NF-κB signaling, and they indicate a possible treatment overlap between these 2 diseases.

银屑病和红斑痤疮都是慢性炎症性皮肤病,由角质形成细胞-免疫细胞异常串扰引起,但人们对这两种疾病的共同分子基础知之甚少。在这里,我们发现银屑病和红斑痤疮患者及其小鼠模型的病变皮肤中 SERPINB3/B4(丝氨酸蛋白酶抑制剂成员)的表达量都显著升高。小鼠的皮肤炎症与银屑病和酒渣鼻相似,但 SERPINB3/B4 缺乏症可防止皮肤炎症。从机理上讲,我们证明了 SERPINB3/B4 能积极诱导 NF-κB 信号激活,从而刺激角朊细胞产生疾病特征性炎症趋化因子和细胞因子,并促进 CD4+ T 细胞的趋化。我们的研究结果表明,在角朊细胞中,SERPINB3/B4 可能通过刺激 NF-κB 信号转导参与了银屑病和酒糟鼻的发病机制,这表明这两种疾病的治疗可能存在重叠。
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引用次数: 0
Breaking the Vicious Cycle of Staphylococcal aureus Skin Colonization and Progression of Cutaneous T-Cell Lymphoma. 打破金黄色葡萄球菌皮肤定植与皮肤 T 细胞淋巴瘤恶化的恶性循环
Pub Date : 2024-12-01 Epub Date: 2024-07-14 DOI: 10.1016/j.jid.2024.05.021
Marshall E Kadin, Robert G Hamilton
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引用次数: 0
A European Roundtable "Addressing Under-Prioritized Skin Diseases: Policy Responses to High-Burden Conditions". 欧洲圆桌会议 "应对未被充分重视的皮肤病:2024 年 2 月 6 日,欧洲圆桌会议 "应对未被充分重视的皮肤病:高负担疾病的对策"。
Pub Date : 2024-12-01 Epub Date: 2024-07-16 DOI: 10.1016/j.jid.2024.05.019
Yalchin Mammadov, Jennifer Austin, Tammi Shipowick, Karin Veldman, Sabine Eming, Andrea Szegedi, Eli Sprecher, Curdin Conrad
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引用次数: 0
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The Journal of investigative dermatology
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