Pub Date : 2024-10-29DOI: 10.1016/j.jid.2024.09.019
Nina Rossa Haddad, Beita Badiei, S Leigh Curvin-Aquilla, Arieana Y Johnson, Aiden Willis, Hana B Minsky, Kaitlin L Williams, Luis A Garza
{"title":"Links between Plastics Use, Processed Food, Sweating, and Hidradenitis Suppurativa.","authors":"Nina Rossa Haddad, Beita Badiei, S Leigh Curvin-Aquilla, Arieana Y Johnson, Aiden Willis, Hana B Minsky, Kaitlin L Williams, Luis A Garza","doi":"10.1016/j.jid.2024.09.019","DOIUrl":"10.1016/j.jid.2024.09.019","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-29DOI: 10.1016/j.jid.2024.09.018
Crystal T Chang, Pirunthan Pathmarajah, Johan Allerup, Sheharbano Jafry, Kiana Yekrang, Dominique C Mitchell, Niki Ai See, Lila A Perrone, Bradley Fong, Miah D Cisneros, Roxana Daneshjou, Justin Ko, Albert S Chiou
{"title":"DDI-2: A Diverse Skin Condition Image Dataset Representing Self-Identified Asian Patients.","authors":"Crystal T Chang, Pirunthan Pathmarajah, Johan Allerup, Sheharbano Jafry, Kiana Yekrang, Dominique C Mitchell, Niki Ai See, Lila A Perrone, Bradley Fong, Miah D Cisneros, Roxana Daneshjou, Justin Ko, Albert S Chiou","doi":"10.1016/j.jid.2024.09.018","DOIUrl":"10.1016/j.jid.2024.09.018","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CXCL12 and its receptor CXCR4 emerge as critical regulators within the intricate network of processes ensuring skin homeostasis. In this review, we discuss their spatial distribution and function in steady-state skin; delve into their role in acute wound healing, with emphasis on fibrotic and regenerative responses; and explore their relevance in skin responses to commensals and pathogens. Given the lack of knowledge surrounding ACKR3, the atypical receptor of CXCL12, we speculate whether and how it might be involved in the processes mentioned earlier. Is ACKR3 the (a)typical friend who enjoys missing the party, or do we need to take a closer look?
{"title":"ACKR3 in Skin Homeostasis, an Overlooked Player in the CXCR4/CXCL12 Axis.","authors":"Gabriela Cuesta-Margolles, Géraldine Schlecht-Louf, Françoise Bachelerie","doi":"10.1016/j.jid.2024.08.022","DOIUrl":"https://doi.org/10.1016/j.jid.2024.08.022","url":null,"abstract":"<p><p>CXCL12 and its receptor CXCR4 emerge as critical regulators within the intricate network of processes ensuring skin homeostasis. In this review, we discuss their spatial distribution and function in steady-state skin; delve into their role in acute wound healing, with emphasis on fibrotic and regenerative responses; and explore their relevance in skin responses to commensals and pathogens. Given the lack of knowledge surrounding ACKR3, the atypical receptor of CXCL12, we speculate whether and how it might be involved in the processes mentioned earlier. Is ACKR3 the (a)typical friend who enjoys missing the party, or do we need to take a closer look?</p>","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-26DOI: 10.1016/j.jid.2024.05.036
Elizabeth A Grice, Donna Brennan-Crispi, Natalia Rodriguez, David J Margolis, John T Seykora, George Cotsarelis, Susan C Taylor, Jamie Shuda
{"title":"Penn Academy for Skin Health (PASH): An Experiential Pipeline Program in Skin Biology and Dermatology for High-School Students.","authors":"Elizabeth A Grice, Donna Brennan-Crispi, Natalia Rodriguez, David J Margolis, John T Seykora, George Cotsarelis, Susan C Taylor, Jamie Shuda","doi":"10.1016/j.jid.2024.05.036","DOIUrl":"https://doi.org/10.1016/j.jid.2024.05.036","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-25DOI: 10.1016/j.jid.2024.07.033
Pierre A Coulombe, David Hansen, Robyn Hickerson, Alain Hovnanian, Edel A O'Toole, David P Kelsell, Holly Evans, Janice Schwartz, Eli Sprecher
{"title":"Celebrating 20 Years of the International Pachyonychia Congenita Consortium.","authors":"Pierre A Coulombe, David Hansen, Robyn Hickerson, Alain Hovnanian, Edel A O'Toole, David P Kelsell, Holly Evans, Janice Schwartz, Eli Sprecher","doi":"10.1016/j.jid.2024.07.033","DOIUrl":"https://doi.org/10.1016/j.jid.2024.07.033","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-18DOI: 10.1016/j.jid.2024.08.001
Gerald S Lazarus, Luis A Diaz
{"title":"Lowell A. Goldsmith: Physician, Scientist, Educator, Mentor, Friend (March 29, 1938-July 10, 2024).","authors":"Gerald S Lazarus, Luis A Diaz","doi":"10.1016/j.jid.2024.08.001","DOIUrl":"https://doi.org/10.1016/j.jid.2024.08.001","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-10DOI: 10.1016/j.jid.2024.09.016
Seung-Phil Hong, Uyanga Batzorig, Celia Fernández-Méndez, Yifang Chen, Ye Liu, Samiksha Mahapatra, George L Sen
{"title":"Hnrnpu Is Essential for Proper Murine Skin Development.","authors":"Seung-Phil Hong, Uyanga Batzorig, Celia Fernández-Méndez, Yifang Chen, Ye Liu, Samiksha Mahapatra, George L Sen","doi":"10.1016/j.jid.2024.09.016","DOIUrl":"10.1016/j.jid.2024.09.016","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142407356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-10DOI: 10.1016/j.jid.2024.08.040
Rashi Yadav, Morgan Vague, Malia Rettig, Christopher P Loo, Kasidy Brown, Abrar Samiea, Joshua M Moreau, Alex G Ortega-Loayza
{"title":"IL-12/IL-23 Blockade Reveals Patterns of Asynchronous Inflammation in Pyoderma Gangrenosum.","authors":"Rashi Yadav, Morgan Vague, Malia Rettig, Christopher P Loo, Kasidy Brown, Abrar Samiea, Joshua M Moreau, Alex G Ortega-Loayza","doi":"10.1016/j.jid.2024.08.040","DOIUrl":"10.1016/j.jid.2024.08.040","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142407357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-10DOI: 10.1016/j.jid.2024.08.039
Lihi Eder, Stephan M Caucheteux, Somaieh Afiuni-Zadeh, David Croitoru, Adriana Krizova, James J Limacher, Christopher Ritchlin, Hartland Jackson, Vincent Piguet
Imaging mass cytometry is a technology that enables comprehensive analysis of cellular phenotypes at the tissue level. We performed a multiparameter characterization of structural and immune cell populations in psoriatic skin and synovial tissue samples aimed at characterizing immune cell differences in patients with psoriasis and psoriatic arthritis. A panel of 33 antibodies was used to stain selected immune and structural cell populations. Imaging mass cytometry data were segmented into single cells on the basis of combinations of antibody stains. Single cells were then clustered into cell categories on the basis of prespecified markers. The spatial relationships of different cell populations were assessed using neighborhood analysis. Among all cell types in the skin and synovium, lymphoid cells accounted for the most prevalent cell type. T cells and macrophages were the most prevalent immune cell type in the synovium, and B cells and NK cells were also identified. Neighborhood analysis showed high correlation between synovial T cells, B cells, macrophages, dendritic cells, and neutrophils, suggesting spatial organization. Innate and adaptive immune cells can be reliably identified using imaging mass cytometry in the skin and synovium. Interpatient heterogeneity exists in tissue cell populations. Imaging mass cytometry provides opportunities for exploring in depth the underlying immunological mechanisms driving psoriasis and psoriatic arthritis.
{"title":"Imaging Mass Cytometry in Psoriatic Disease Reveals Immune Profile Heterogeneity in Skin and Synovial Tissue.","authors":"Lihi Eder, Stephan M Caucheteux, Somaieh Afiuni-Zadeh, David Croitoru, Adriana Krizova, James J Limacher, Christopher Ritchlin, Hartland Jackson, Vincent Piguet","doi":"10.1016/j.jid.2024.08.039","DOIUrl":"10.1016/j.jid.2024.08.039","url":null,"abstract":"<p><p>Imaging mass cytometry is a technology that enables comprehensive analysis of cellular phenotypes at the tissue level. We performed a multiparameter characterization of structural and immune cell populations in psoriatic skin and synovial tissue samples aimed at characterizing immune cell differences in patients with psoriasis and psoriatic arthritis. A panel of 33 antibodies was used to stain selected immune and structural cell populations. Imaging mass cytometry data were segmented into single cells on the basis of combinations of antibody stains. Single cells were then clustered into cell categories on the basis of prespecified markers. The spatial relationships of different cell populations were assessed using neighborhood analysis. Among all cell types in the skin and synovium, lymphoid cells accounted for the most prevalent cell type. T cells and macrophages were the most prevalent immune cell type in the synovium, and B cells and NK cells were also identified. Neighborhood analysis showed high correlation between synovial T cells, B cells, macrophages, dendritic cells, and neutrophils, suggesting spatial organization. Innate and adaptive immune cells can be reliably identified using imaging mass cytometry in the skin and synovium. Interpatient heterogeneity exists in tissue cell populations. Imaging mass cytometry provides opportunities for exploring in depth the underlying immunological mechanisms driving psoriasis and psoriatic arthritis.</p>","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142407358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号