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Adaptive immune response to a wild boar-derived recombinant hepatitis e virus capsid protein challenge in pigs.
Pub Date : 2025-01-12 Epub Date: 2024-11-30 DOI: 10.1016/j.vaccine.2024.126561
Juozas Grigas, Ugne Spancerniene, Martynas Simanavicius, Arnoldas Pautienius, Rolandas Stankevicius, Paulius Lukas Tamosiunas, Arunas Stankevicius

Hepatitis E virus genotype 3 (HEV-3) is a zoonotic pathogen capable of infecting human, porcine, and other animal hosts. Despite a broad host range and abundance of species that act as reservoirs for human infections, no commercially available animal vaccines against HEV-3 are currently available. In the present study, we tested the capacity of recombinant aa 112-608 wild boar-derived HEV-3 capsid protein (rORF2p) to induce an immune response in immunized pigs. Four 6 week old pigs were administered 1 ml of 200 μg/ml rORF2p, followed by booster administration after 14 days. Blood samples were collected until 28 days after initial immunization. Dominant cell phenotypes and anti-HEV IgG concentrations were determined. A significant anti-HEV IgG, monocyte/macrophage, B cell and T cell response has been detected in immunized pigs. In turn, our findings suggest the capacity of rORF2p to elicit an immune response in pigs, suggesting the potential for its use as a vaccine candidate.

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引用次数: 0
Corrigendum to "Influenza B/Yamagata - extinct, eradicated or hiding? [Vaccine 42/26 (2024) 126450]". 乙型/山形流感--灭绝、根除还是隐藏?[疫苗 42/26 (2024) 126450]》。
Pub Date : 2025-01-12 Epub Date: 2024-10-29 DOI: 10.1016/j.vaccine.2024.126486
Chandini R MacIntyre, Zubair Akhtar, Aye Moa
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引用次数: 0
COVID-19 vaccine effectiveness against severe omicron-related outcomes in children aged 5 to 11 years in Ontario: A Canadian immunization research network (CIRN) study.
Pub Date : 2025-01-12 Epub Date: 2024-11-30 DOI: 10.1016/j.vaccine.2024.126539
Pierre-Philippe Piché-Renaud, Samantha S M Drover, Peter C Austin, Shaun K Morris, Sarah A Buchan, Sharifa Nasreen, Kevin L Schwartz, Mina Tadrous, Nisha Thampi, Sarah E Wilson, Kumanan Wilson, Astrid Guttmann, Jeffrey C Kwong

Background: Understanding how the efficacy of COVID-19 vaccines translates from clinical trials to real-world settings is critical to inform evolving vaccination policies. The objective of this study was to assess COVID-19 vaccine effectiveness (VE) against severe COVID-19-related outcomes in children aged 5-11 years, including COVID-19-related hospital admissions and multisystem inflammatory syndrome in children (MIS-C).

Methods: We conducted a retrospective, population-based cohort study using linked health administrative data in the first year following the emergence of the Omicron variant (January 2 to December 31, 2022) in Ontario, Canada. Baseline differences between subgroups of interest were compared using standardized differences. We used multivariable Cox proportional hazard regression models to estimate VE by time since last vaccine dose by treating vaccination as a time-varying exposure, compared to unvaccinated children.

Results: We included a total of 1,058,740 children, of which 583,867 (55.1 %) had received at least one vaccine dose by the end of the study period. In total, there were 185 COVID-19-related hospital admissions and 39 cases of MIS-C. The rate of COVID-19-related admission was substantially higher in children with an underlying comorbid condition compared to children who were previously healthy (adjusted hazard ratio [aHR] = 4.77, 95 %CI, 3.56-6.38). VE against COVID-19-related admission ranged from 93 % (95 %CI, 52-99 %) 7-29 days after a second dose to 63 % (95 %CI; 41-77 %) ≥120 days after a second dose. There was no statistically significant difference in the rate of MIS-C in children who received at least one dose of the vaccine compared to unvaccinated children (aHR = 0.71; 95 %CI, 0.38-1.34).

Conclusions: We found that, for children aged 5-11 years, VE against COVID-19-related hospitalization was high in the first four months after a second dose. Children with comorbid conditions were found to be at much higher risk of COVID-19-related severe outcomes and thus may benefit most from COVID-19 vaccination.

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引用次数: 0
Social complexity of a fentanyl vaccine to prevent opioid overdose conference proceedings: Radcliffe Institute for Advanced Study conference proceedings. 预防阿片类药物过量的芬太尼疫苗的社会复杂性会议记录:拉德克里夫高级研究所会议记录。
Pub Date : 2025-01-12 Epub Date: 2024-09-23 DOI: 10.1016/j.vaccine.2024.126324
Elissa R Weitzman, Margarita Alegria, Arthur Caplan, David Dowling, Jay Evans, Carl Erik Fisher, Ayana Jordan, Joe Kossowsky, Misia Landau, Heidi Larson, Ofer Levy, Sharon Levy, Seth Mnookin, Sharon Reif, Jennifer Ross, Amy Caryn Sherman

Despite significant public health attention and investment, hundreds of thousands of individuals have suffered fatal opioid overdose since the onset of the opioid crisis. Risk of opioid overdose has been exacerbated by the influx of fentanyl, a powerful synthetic opioid, into the drug supply. The National Institutes of Health Helping End Addiction Long-term (HEAL) Initiative is supporting the development of vaccines targeting fentanyl to protect against overdose. If successful, a vaccine would induce anti-fentanyl antibodies to sequester fentanyl (but not other opioids) in the blood, preventing fentanyl from crossing into the brain and reaching the central nervous system where it can cause overdose. Introduction of an overdose preventing strategy that relies on a vaccine to confer passive protection may be impactful. However, vaccines are poorly understood by the public and politicized. Moreover, the overdose ecosystem is complex and extends across numerous social, economic, medical, and cultural systems. As such, optimal use of a vaccine strategy to address overdose may benefit from multidisciplinary consideration of the social, ethical, and systemic factors that influence substance use and overdose that may also impact the acceptability of a fentanyl vaccine and related implementation strategies. In March 2022, Dr. Elissa Weitzman convened a two-day conference at the Harvard Radcliffe Institute for Advanced Study on the Social Complexity of a Fentanyl Vaccine to Prevent Opioid Overdose. In all, 19 professionals from diverse disciplines (medicine, psychology, history, ethics, immunology, vaccinology, communications, policy) attended the conference and led discussions that centered on population health and epidemiology, history of medicine and frameworks for understanding substance use, ethics, decision-making and attitudes, and operational issues to the question of a novel immunotherapy targeting fentanyl overdose. Participants also debated the risks and benefits of vaccine administration in response to fictional clinical case vignettes. A summary of the conference presentations and discussions follows.

自阿片类药物危机爆发以来,尽管公共卫生得到了极大的关注和投入,但仍有数十万人因阿片类药物过量而丧命。阿片类药物过量的风险因强效合成阿片类药物芬太尼涌入毒品供应而加剧。美国国立卫生研究院的 "长期帮助戒毒(HEAL)计划 "正在支持开发针对芬太尼的疫苗,以防止用药过量。如果研制成功,疫苗将诱导抗芬太尼抗体在血液中封存芬太尼(而非其他阿片类药物),防止芬太尼进入大脑并到达中枢神经系统,从而导致用药过量。引入一种依靠疫苗提供被动保护的预防用药过量策略可能会产生影响。然而,疫苗并不为公众所了解,而且被政治化了。此外,用药过量的生态系统非常复杂,横跨众多社会、经济、医疗和文化系统。因此,如果能从多学科角度考虑影响药物使用和用药过量的社会、伦理和系统性因素,并对芬太尼疫苗和相关实施策略的可接受性产生影响,就能优化使用疫苗策略来解决用药过量问题。2022 年 3 月,Elissa Weitzman 博士在哈佛大学拉德克利夫高级研究所召开了为期两天的会议,讨论芬太尼疫苗预防阿片类药物过量的社会复杂性。共有 19 位来自不同学科(医学、心理学、历史学、伦理学、免疫学、疫苗学、传播学、政策学)的专业人士参加了会议,并围绕人口健康和流行病学、医学史和药物使用理解框架、伦理学、决策和态度以及针对芬太尼过量的新型免疫疗法的操作问题展开了讨论。与会者还针对虚构的临床病例讨论了接种疫苗的风险和益处。会议发言和讨论摘要如下。
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引用次数: 0
Corrigendum to "A comparison of four self-controlled study designs in an analysis of COVID-19 vaccines and myocarditis using five European databases" [Vaccine 42 (12) (2024) 3039-3048]. 利用五个欧洲数据库对 COVID-19 疫苗与心肌炎的分析中四种自控研究设计的比较》[Vaccine 42 (12) (2024) 3039-3048] 的更正。
Pub Date : 2025-01-12 Epub Date: 2024-10-13 DOI: 10.1016/j.vaccine.2024.126438
Anna Schultze, Ivonne Martin, Davide Messina, Sophie Bots, Svetlana Belitser, Juan José Carreras-Martínez, Elisa Correcher-Martinez, Arantxa Urchueguía-Fornes, Mar Martín-Pérez, Patricia García-Poza, Felipe Villalobos, Meritxell Pallejà-Millán, Carlo Alberto Bissacco, Elena Segundo, Patrick Souverein, Fabio Riefolo, Carlos E Durán, Rosa Gini, Miriam Sturkenboom, Olaf Klungel, Ian Douglas
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引用次数: 0
Sex differences in parental reasons for lack of intent to initiate HPV vaccination among adolescents ages 13-17 years: National Immunization Survey - Teen 2019-2021.
Pub Date : 2025-01-12 Epub Date: 2024-12-06 DOI: 10.1016/j.vaccine.2024.126584
Erika Escabí-Wojna, Paola M Alvelo-Fernández, Erick Suárez, Vivian Colón-López

Background: This study aimed to evaluate parents' main reasons for lack of intent to vaccinate their adolescent against human papillomavirus (HPV) from 2019 to 2021 and to examine changes in these main reasons stratified by sex of the adolescent.

Methods: NIS-Teen data from 2019 to 2021 were used. Parents who had not vaccinated their adolescent aged 13-17 against HPV and had no intent to do so in the next 12 months were asked the main reason behind this decision. Reasons were grouped into eight domains. A multinomial logistic regression model stratified by sex was used to assess changes in the likelihood of each domain for 2020 and 2021 in comparison to 2019.

Results: A significant interaction between the reasons for lack of intent to vaccinate against HPV and year by sex was documented (p < 0.001). For males, the odds of parents reporting vaccine misinformation (ORadj: 1.30, 95 % CI: 1.26, 1.35), safety and effectiveness concerns (ORadj: 1.08, 95 % CI: 1.05, 1.12), systemic barriers (ORadj: 2.57, 95 % CI: 2.48, 2.66), lack of knowledge (ORadj: 1.44, 95 % CI: 1.39, 1.49), sociocultural barriers (ORadj: 3.20, 95 % CI: 3.09, 3.32), already UTD (ORadj: 2.48, 95 % CI: 2.39, 2.56), and handicapped/special needs/illness (ORadj: 1.88, 95 % CI: 1.79, 1.97), were significantly higher in 2021 compared to 2019. Whereas for females, the odds of reporting all domains were significantly lower in 2021 compared to 2019.

Conclusion: The main domain reported was vaccine misinformation. Parents of males were more likely to report all domains in 2021 compared to 2019, the inverse of females. These can be addressed through public health interventions such as launching media campaigns to combat vaccine misinformation tailored to parents of male adolescents.

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引用次数: 0
Association of baseline cytokines with antibody concentrations after diphtheria-tetanus-acellular pertussis booster vaccination in Finnish children.
Pub Date : 2025-01-12 Epub Date: 2024-11-30 DOI: 10.1016/j.vaccine.2024.126573
Denise Anabe, Johanna T Teräsjärvi, Alex-Mikael Barkoff, Aapo Knuutila, Bernd Pape, Pieter van Gageldonk, Annemarie Buisman, Jussi Mertsola, Qiushui He

Background: Despite extensive vaccinations, pertussis remains endemic and epidemic in multiple countries. The persistence of cases can be partly attributed to the significant individual variation in vaccine responses. This study evaluated the association of baseline cytokines (before booster vaccination) on antibody concentrations to Tdap-vaccine antigens.

Methods: Healthy Finnish children (7-10y, n = 36), adolescents (11-15y, n = 37), young adults (20-34y, n = 25), and older adults (60-70y, n = 23) received a Tdap3-IPV booster. Serum antibodies against pertussis toxin (PT), filamentous hemagglutinin (FHA), pertactin (Prn), fimbriae 2/3, diphtheria toxoid (DT), and tetanus toxoid (TT), as well as PT neutralizing antibodies were measured before, one month, and one year after the booster. Baseline serum concentrations of IFN-γ, IL-2, IL-5, IL-10, IL-13, IL-17 A and IL-17F were determined.

Results: The proportion of detectable and undetectable baseline cytokines varied between age groups 58.3 % of children had a higher proportion of detectable IL-5, IL-10, IL-13, and IL-17F compared to adolescents (IL-5, 37.8 %; IL-10, 48.6 %; IL-13, 48.6 %; IL-17F, 37.7 %), young adults (IL-5, 36.0 %; IL-10, 28.0 %; IL-13, 36.0 %; IL-17F, 44.0 %), and older adults (IL-5, 26.1 %; IL-10, 21.7 %; IL-13, 39.1 %; IL-17F, 30.4 %). IFN-γ had a lower detectability in children (44.4 %) and young (40.0 %) and older adults (39.1 %) in contrast to adolescents (62.2 %). IL-2 was undetectable in all age groups while the proportion of detectable IL-17 A decreased with age. A mixed model showed that undetectable baseline levels of IFN-γ, IL-2, IL-10, and IL-17 A were associated with higher antibody concentrations in children before and after vaccination, particularly against PT. Positive associations were observed in adolescents for anti-TT concentrations and young adults for anti-FHA IgA concentrations.

Conclusion: These findings indicate a possible role of existing cytokines in pertussis booster antibody concentrations in children and warrant further studies in different populations. However, the results should be interpreted with caution as the number of subjects is limited.

{"title":"Association of baseline cytokines with antibody concentrations after diphtheria-tetanus-acellular pertussis booster vaccination in Finnish children.","authors":"Denise Anabe, Johanna T Teräsjärvi, Alex-Mikael Barkoff, Aapo Knuutila, Bernd Pape, Pieter van Gageldonk, Annemarie Buisman, Jussi Mertsola, Qiushui He","doi":"10.1016/j.vaccine.2024.126573","DOIUrl":"10.1016/j.vaccine.2024.126573","url":null,"abstract":"<p><strong>Background: </strong>Despite extensive vaccinations, pertussis remains endemic and epidemic in multiple countries. The persistence of cases can be partly attributed to the significant individual variation in vaccine responses. This study evaluated the association of baseline cytokines (before booster vaccination) on antibody concentrations to Tdap-vaccine antigens.</p><p><strong>Methods: </strong>Healthy Finnish children (7-10y, n = 36), adolescents (11-15y, n = 37), young adults (20-34y, n = 25), and older adults (60-70y, n = 23) received a Tdap3-IPV booster. Serum antibodies against pertussis toxin (PT), filamentous hemagglutinin (FHA), pertactin (Prn), fimbriae 2/3, diphtheria toxoid (DT), and tetanus toxoid (TT), as well as PT neutralizing antibodies were measured before, one month, and one year after the booster. Baseline serum concentrations of IFN-γ, IL-2, IL-5, IL-10, IL-13, IL-17 A and IL-17F were determined.</p><p><strong>Results: </strong>The proportion of detectable and undetectable baseline cytokines varied between age groups 58.3 % of children had a higher proportion of detectable IL-5, IL-10, IL-13, and IL-17F compared to adolescents (IL-5, 37.8 %; IL-10, 48.6 %; IL-13, 48.6 %; IL-17F, 37.7 %), young adults (IL-5, 36.0 %; IL-10, 28.0 %; IL-13, 36.0 %; IL-17F, 44.0 %), and older adults (IL-5, 26.1 %; IL-10, 21.7 %; IL-13, 39.1 %; IL-17F, 30.4 %). IFN-γ had a lower detectability in children (44.4 %) and young (40.0 %) and older adults (39.1 %) in contrast to adolescents (62.2 %). IL-2 was undetectable in all age groups while the proportion of detectable IL-17 A decreased with age. A mixed model showed that undetectable baseline levels of IFN-γ, IL-2, IL-10, and IL-17 A were associated with higher antibody concentrations in children before and after vaccination, particularly against PT. Positive associations were observed in adolescents for anti-TT concentrations and young adults for anti-FHA IgA concentrations.</p><p><strong>Conclusion: </strong>These findings indicate a possible role of existing cytokines in pertussis booster antibody concentrations in children and warrant further studies in different populations. However, the results should be interpreted with caution as the number of subjects is limited.</p>","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":" ","pages":"126573"},"PeriodicalIF":0.0,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142776171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using human papillomavirus (HPV) vaccine in controlled temperature chain (CTC): A solution looking for a problem? Or a solution to problems that are not systematically documented? 在可控温度链 (CTC) 中使用人类乳头瘤病毒 (HPV) 疫苗:寻找问题的解决方案?还是对没有系统记录的问题的解决方案?
Pub Date : 2025-01-12 Epub Date: 2024-09-28 DOI: 10.1016/j.vaccine.2024.126399
Dijana Spasenoska, Paul Bloem, Hiroki Akaba, Anna-Lea Kahn
{"title":"Using human papillomavirus (HPV) vaccine in controlled temperature chain (CTC): A solution looking for a problem? Or a solution to problems that are not systematically documented?","authors":"Dijana Spasenoska, Paul Bloem, Hiroki Akaba, Anna-Lea Kahn","doi":"10.1016/j.vaccine.2024.126399","DOIUrl":"10.1016/j.vaccine.2024.126399","url":null,"abstract":"","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":" ","pages":"126399"},"PeriodicalIF":0.0,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
One-year follow-up evaluation of approved Subolesin anti-tick vaccine in Uganda.
Pub Date : 2025-01-12 Epub Date: 2024-11-29 DOI: 10.1016/j.vaccine.2024.126562
Paul D Kasaija, Fredrick Kabi, Jimmy Semakula, Ivan Kyakuwa, Marinela Contreras, Gabriela de la Fuente, Justus Rutaisire, Swidiq Mugerwa, Christian Gortázar, José de la Fuente

After approval of the Subolesin-based anti-tick vaccine in Uganda, we completed a one-year follow-up evaluation study. The results showed significantly 2.1-5.0-fold higher anti-SUB IgG antibody titers in vaccinated cattle in Mbarara and Maruzi with vaccine effectiveness higher than 95 %. In Mbarara, total number of ticks were 0.8-fold lower in vaccinated cattle with a negative correlation tendency between anti-SUB antibody titers and tick counts. The CCHFV-seropositive cattle significantly decreased in 40 % in SUB-vaccinated animals with a significant positive correlation between CCHFV-seropositive cattle and the total number of ticks per animal and a negative correlation tendency between anti-SUB antibody titers and CCHFV-seropositive cattle. A boosting vaccine dose yearly after primary vaccination with three doses is sufficient to maintain protective antibody titers against ticks and tick-borne diseases affecting human and animal health. These results are relevant for implementation of anti-tick Subolesin-based vaccines in Uganda and other countries in Sub-Saharan Africa.

{"title":"One-year follow-up evaluation of approved Subolesin anti-tick vaccine in Uganda.","authors":"Paul D Kasaija, Fredrick Kabi, Jimmy Semakula, Ivan Kyakuwa, Marinela Contreras, Gabriela de la Fuente, Justus Rutaisire, Swidiq Mugerwa, Christian Gortázar, José de la Fuente","doi":"10.1016/j.vaccine.2024.126562","DOIUrl":"10.1016/j.vaccine.2024.126562","url":null,"abstract":"<p><p>After approval of the Subolesin-based anti-tick vaccine in Uganda, we completed a one-year follow-up evaluation study. The results showed significantly 2.1-5.0-fold higher anti-SUB IgG antibody titers in vaccinated cattle in Mbarara and Maruzi with vaccine effectiveness higher than 95 %. In Mbarara, total number of ticks were 0.8-fold lower in vaccinated cattle with a negative correlation tendency between anti-SUB antibody titers and tick counts. The CCHFV-seropositive cattle significantly decreased in 40 % in SUB-vaccinated animals with a significant positive correlation between CCHFV-seropositive cattle and the total number of ticks per animal and a negative correlation tendency between anti-SUB antibody titers and CCHFV-seropositive cattle. A boosting vaccine dose yearly after primary vaccination with three doses is sufficient to maintain protective antibody titers against ticks and tick-borne diseases affecting human and animal health. These results are relevant for implementation of anti-tick Subolesin-based vaccines in Uganda and other countries in Sub-Saharan Africa.</p>","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":"44 ","pages":"126562"},"PeriodicalIF":0.0,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to "Immunogenicity during 6 months after SARS-CoV-2 infection is significantly different depending on previous COVID-19 vaccine regimens and a booster dose received" [Vaccine 42 (22) (2024) 126025]. 对 "SARS-CoV-2 感染后 6 个月内的免疫原性因以前的 COVID-19 疫苗接种方案和接受的加强剂量不同而有显著差异 "的更正[疫苗 42 (22) (2024) 126025]。
Pub Date : 2025-01-12 Epub Date: 2024-09-27 DOI: 10.1016/j.vaccine.2024.126403
Paskorn Sritipsukho, Pakatip Sinlapamongkolkul, Araya Satdhabudha, Chanapai Chaiyakulsil, Surakameth Mahasirimongkol, Waritta Sawaengdee, Waraphorn Fukpho, Thana Khawcharoenporn
{"title":"Corrigendum to \"Immunogenicity during 6 months after SARS-CoV-2 infection is significantly different depending on previous COVID-19 vaccine regimens and a booster dose received\" [Vaccine 42 (22) (2024) 126025].","authors":"Paskorn Sritipsukho, Pakatip Sinlapamongkolkul, Araya Satdhabudha, Chanapai Chaiyakulsil, Surakameth Mahasirimongkol, Waritta Sawaengdee, Waraphorn Fukpho, Thana Khawcharoenporn","doi":"10.1016/j.vaccine.2024.126403","DOIUrl":"10.1016/j.vaccine.2024.126403","url":null,"abstract":"","PeriodicalId":94264,"journal":{"name":"Vaccine","volume":" ","pages":"126403"},"PeriodicalIF":0.0,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Vaccine
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