Vaccine最新文献

Objective: Gansu Province, an underdeveloped region in northwest China, has a low HPV vaccination rate among girls aged 9-14 despite government promotion efforts. This study aims to investigate the current status of HPV vaccination among girls aged 9-14 in Gansu Province, explore guardians' willingness to vaccinate their daughters and analyze the influencing factors, to provide scientific evidence for improving the HPV vaccination rate and government vaccine promotion measures for girls aged 9-14.

Methods: HPV vaccine procurement and usage data (2018-2023) were extracted from provincial platforms, and demographic data were sourced from national census and statistical yearbooks to analyze the current status of HPV vaccination among girls aged 9 to 14 in Gansu Province. From January to May 2024, 1027 guardians of 9-14-year-old girls were surveyed via questionnaires. Logistic regression, restricted cubic spline (RCS), and mediation analysis assessed factors influencing vaccination willingness.

Results: The vaccination rate rose slowly from 2018 to 2022 but surged to 0.76 % in 2023. Among participants, 25.51 % of guardians expressed hesitancy to have their daughters vaccinated against HPV. Socioeconomic status (SES) and HPV and vaccine knowledge positively correlated with willingness (P < 0.001). Guardians with medium (OR = 1.69, 95 % CI: 1.15, 2.51) and high (OR = 7.42, 95 % CI: 4.89, 11.48) knowledge levels showed stronger vaccination willingness. RCS analysis revealed non-linear dose-response relationships between SES/knowledge scores and vaccination willingness (P_non-linear < 0.01). Mediation analysis revealed that cognition played a completely mediating role between SES and vaccination willingness.

Conclusions: HPV vaccination coverage in Gansu remains low and uneven. Guardians demonstrated high willingness but faced barriers linked to SES and knowledge gaps. Policies prioritizing free vaccines or subsidies, alongside educational campaigns, are critical to improving uptake.

Tissue-resident memory T cells (TRMs) are integral to localized immune defense, characterized by their capacity for long-term tissue residency and rapid effector responses in infectious diseases. Beyond their established roles in antimicrobial immunity, TRMs exhibit unique therapeutic potential in tumor immunology and vaccine design. This review summarizes the advances in TRM biology, emphasizing molecular determinants of tissue residency, functional specialization across tissue niches, and mechanistic insights into pathogen-specific immunity. We highlight the roles of TRMs in cancer and their critical function in combating infections, including viral, bacterial, and parasitic challenges. Furthermore, we critically evaluate vaccine strategies leveraging TRM biology, such as mucosal delivery, adjuvant modulation, and antigen persistence engineering, to enhance protective immunity. Addressing challenges like interspecies discrepancies in TRM longevity and exhaustion dynamics will be pivotal for translating these insights into durable vaccine platforms against infectious diseases and cancer.

Background: Despite longstanding public health efforts, awareness of human papillomavirus (HPV) and the HPV vaccine remains suboptimal. Patterns of trust in health information sources may contribute to lack of HPV prevention awareness.

Objective: To evaluate the association between trust in cancer information sources and awareness of HPV and the HPV vaccine among U.S. adults.

Methods: We used nationally representative data from the 2022 Health Information National Trends Survey (HINTS 6) and conducted survey-weighted logistic regression analyses. The analytic sample included 5222 adults aged 18 and older with complete data. We modeled two outcomes: (1) awareness of HPV and (2) awareness of the HPV vaccine. The main predictor was a trust typology, derived from a latent class analysis of six binary indicators of trusted cancer information sources, categorizing respondents into low, broad, or secular institutional trust groups.

Results: Compared to the low-trust group, respondents in the secular institutional trust group had significantly higher odds of being aware of HPV (OR = 1.59, 95 % CI: 1.18-2.17) and the HPV vaccine (OR = 1.75, 95 % CI: 1.28-2.41). The broad trust group was also more likely to be aware of HPV (OR = 1.40, 95 % CI: 1.03-1.93), though the association with HPV vaccine awareness was not statistically significant.

Conclusions: Greater trust in secular institutions was more strongly associated with HPV-related awareness. Public health communication strategies should tailor outreach efforts to align with multidimensional trust patterns.

Salmonella, a major foodborne zoonotic pathogen, threatens global poultry production and public health. While inactivated vaccines exhibit limited efficacy and live attenuated vaccines raise safety concerns due to risks of virulence reversion, subunit vaccines represent a safer and more targeted alternative. However, existing subunit vaccines against Salmonella provide limited cross-serotype protection. To address this challenge, OmpC, OmpD, OmpF (outer membrane proteins), SseB (a Type III secretory system secretory protein), and FliC (flagellin) were selected as five conserved antigens of Salmonella Enteritidis (S. enteritidis) for evaluation of their immune protective efficacy in this work. Our data showed that all antigens exhibited strong humoral and cell-mediated immune responses specific to each antigen, significantly reducing mortality and bacterial burdens following S. enteritidis challenge compared to infected controls. Notably, the SseB subunit vaccine demonstrated promising but serovar-dependent protection, inducing partial cross-reactive opsonophagocytic antibody (OPA) responses against Salmonella serovars. Protection experiments revealed divergent efficacy: 66.7 % survival against homologous S. enteritidis versus limited 33.3 % survival against heterologous S. typhimurium challenge. Both groups exhibited significantly reduced bacterial colonization and mitigated histopathological damage. These findings position SseB as a key candidate for serovar-specific subunit vaccines, laying the groundwork for multivalent approaches targeting conserved virulence machinery.

Introduction: For children who initiate a vaccine series late, the Centers for Disease Control and Prevention (CDC) provides a catch-up schedule to guide providers in achieving full vaccination. Typically, the routine and catch-up schedules recommend the same number of doses for series completion. However, children starting pneumococcal (PCV) or Haemophilus influenzae type b (Hib) vaccination at or after 7 months often require fewer doses than earlier initiators. We aimed to quantify late PCV and Hib series initiators and determine series completion within CDC catch-up guidelines.

Methods: This cross-sectional study analyzed vaccine records from the 2016-2021 National Immunization Survey-Child. We quantified the prevalence of and identified characteristics of children who initiated the PCV or Hib series at or after age 7 months (215 days). We evaluated late initiators' series completion based on age of series initiation and when subsequent doses were received.

Results: Of 99,652 children, 2.5 % (95 % CI: 2.2-2.7 %) and 2.3 % (95 % CI: 2.1-2.5 %) of U.S. children initiated PCV or Hib series late, respectively. The median age of late series initiation was 384 days for PCV and 407 days for Hib. Overall, 34.9 % (95 % CI: 29.9-39.9 %) of late PCV initiators, and 26.3 % (95 % CI: 21.2-31.4 %) of late Hib initiators, received other vaccines from age 6 weeks to <7 months. Late PCV initiation decreased from 2.9 % (95 % CI: 2.4-3.4 %) in 2016 to 1.7 % (95 % CI: 1.3-2.1 %) in 2021. About 77.4 % (95 % CI: 69.0-83.9 %) of late PCV (routine 4-dose series) and 87.5 % (95 % CI: 76.3-93.3 %) of late Hib (routine 4-dose series) initiators completed the series per catch-up guidelines.

Conclusions: A subset of U.S. children initiated the PCV or Hib series at or after 7 months, and most had not received other recommended vaccines between 6 weeks and 7 months-underscoring the need for evidence-based interventions that support early access to primary care.

Introduction: Migration presents complex challenges for global public health. Pathogens do not recognise borders, and despite the success of vaccination in reducing infant and child mortality, significant gaps in coverage between migrants and host populations exist. Immigrant or migrant children are most at risk of severe health outcomes due to under- or non-vaccination. Although multiple factors contribute to low vaccination uptake, research has identified factors linked to parental attitudes towards vaccination. These factors are crucial in influencing children's vaccination against preventable diseases.

Aim: The aim of this review is to synthesise and integrate the evidence on the barriers and facilitators associated with migrant parents' decisions to vaccinate their children.

Methods: This review followed the Joanna Briggs Institute methodology for MMSR using a convergent integrated approach. The population, phenomenon of interest, and context (PICo) was applied to formulate the review question. The following databases were systematically searched; MEDLINE Ovid (1946-2024), EMBASE Ovid (1974-2024), Cinahl EBSCO Host (1937-2024), PsycINFO (Ovid), Web of Science and Scopus.

Results: Twenty studies were included, with four themes emerging. 'Health literacy' highlights how language proficiency and knowledge either help or hinder migrant parents' ability to understand, access, and navigate healthcare systems; 'trust in care' refers to their confidence in health and social care professionals and the system delivering childhood vaccinations; 'access' represents the ease or difficulty they face in reaching and using vaccination services; and 'fear and perception' relate to how trust, perceived susceptibility, and the attitudes of family and social networks influence their vaccination decisions.

Conclusion: Vaccination equity is critical for safeguarding migrant and host populations. Addressing this disparity reduces outbreak risks and ensures global health security. The development of culturally and linguistically appropriate vaccination campaigns is needed to educate migrant parents on vaccination benefits and accessibility.

Background: Respiratory syncytial virus (RSV) is the most common cause of infant hospitalization. Following the introduction of a prefusion F protein vaccine (RSVpreF) for pregnant women and a monoclonal antibody (nirsevimab) for infants aged <8 months in 2023, we aimed to understand public perceptions about RSV immunization to inform targeted health strategies to improve uptake.

Methods: We conducted two nationally representative web-based surveys of pregnant women to understand maternal RSV immunization attitudes and intentions (Wave 1: 9/20/2023-10/3/2023; N = 198; Wave 2: 5/24/2024-6/14/2024; N = 216). We used thematic analysis to identify themes and sub-themes in pooled data across both waves (N = 414).

Results: Motivators for immunization included concerns about the disease's risks, recognized benefits of immunization, and recommendations by healthcare professionals and the Center for Disease Control and Prevention (CDC). Participants reported hesitation to immunize due to insufficient immunization information, low perceived disease risk, lack of trust in vaccine due to product novelty and vaccine-makers, limited availability of RSVpreF vaccine, and concerns about vaccine safety and potential side effects. Individuals who reported hesitancy shared that information needed to encourage immunization should include narratives from parents who chose immunization, research, and evidence underscoring the effectiveness and safety of the immunization, and information about access and availability of the products. Trusted sources of immunization information among all participants included (1) healthcare providers, (2) family/relatives, and (3) research.

Conclusion: Our findings suggest that efforts to promote RSV immunization should focus on engaging healthcare providers to improve pregnant women's knowledge and awareness related to RSV and using vaccine narratives to build confidence in RSV immunization.

Tuberculosis (TB) was a significant public health concern in Japan for over a century. While archaeological evidence suggests its presence as early as 1800 years ago, TB spread rapidly during Japan's modernization in the late 19th century. Initial control measures focused on patient isolation and the establishment of sanatoriums, later supported by the Tuberculosis Prevention Law. After World War II, public health interventions-such as mandatory case reporting, mass BCG vaccination, and the introduction of antimycobacterial agents like streptomycin-contributed to a marked decline in TB incidence and mortality. Treatment outcomes further improved with the development of multidrug chemotherapy. Mass BCG vaccination began in 1949, with universal childhood vaccination implemented in 1974. Japan employs a distinctive intradermal "stamp" method with multiple needles of BCG administration for less complication of a skin ulcer. The current strain, BCG Tokyo-172-1, developed in 1981, is used nationally and distributed globally through WHO-UNICEF programs. Pediatric TB has become rare, with fewer than 100 new cases annually. Most are identified through adults contact investigations; others are diagnosed based on clinical symptoms or screening. In recent years, the proportion of TB cases-including pediatric cases-among individuals born outside Japan, particularly from high-burden countries, has increased. As Japan transitions to a low TB burden setting, the continuation of universal BCG vaccination is under review. Selective vaccination of high-risk infants and enhanced screening among adults may offer more targeted and effective approaches.

Canine distemper virus, CDV, is a worldwide distributed disease of the genus Morbillivirus that can affect dogs of all ages, breeds, and both sexes with varying degrees of morbidity and lethality. The virus consists of six structural proteins, of which the Hemagglutinin is responsible for the efficient fusion to the cell membrane, allowing the virus entrance and replication in susceptible animals. The Hemagglutinin protein is responsible for the virus binding to the SLAM and Nectin-4 proteins present on the host cell membrane to start the infection process. This biochemical mechanism is then used to develop vaccines. However, due to the Hemagglutinin amino acid sequence being highly variable in several countries, animals that are vaccinated develop CDV symptoms. To evaluate this low vaccine efficiency in Brazil, this study explores the genetic and molecular basis to understand the differences in the Hemagglutinin phylogenetic profile compared to the vaccine strains. Specifically, Hemagglutinin, SLAM, and Nectin-4 interaction regions are compared to find amino acid mutations responsible for this behavior. For this purpose, a set of molecular modelling programs and protocols was used. Phylogenetic analysis of 102 Hemagglutinin genes highlighted the distances between several groups from the vaccine and the Brazilian strains. To understand the virus recognition specificities, a set of eighteen new tridimensional structures of this receptor was proposed - eleven Brazilian and seven vaccine strains. Despite the high structural similarities, the conformational comparison shows important differences in amino acids on the Hemagglutinin interaction site with SLAM and Nectin-4. Clearly, this lack of the strains circulating in Brazil and the commercial vaccine may explain the protocol failures due to the absence of specific antibodies in the animals to recognize most local CVD, thus evidencing the need for biotechnological efforts to produce vaccines considering a wider range of strains.