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Candida Auris Total Knee Arthroplasty Infection in an Immunocompetent Individual: Case Report and Literature Review. 免疫正常个体的耳念珠菌全膝关节置换术感染:病例报告和文献复习。
Milan Patel, Jacob Kodra, Kaleb Keener, Riya Singh, Pinky Jha

Introduction: Candida auris (C auris), a multidrug-resistant fungus, was declared by the Centers for Disease Control and Prevention as a serious global health threat in 2016. It is hard to identify, resistant to standard antifungal treatments, and spreads within health care settings, resulting in high morbidity and mortality in critically ill patients.

Case presentation: We report the case of a 60-year-old immunocompetent male with a protracted course of prosthetic knee joint infections. He received medical care at several health care facilities across 2 Midwestern states culminating in wound dehiscence and C auris infection necessitating prolonged antimicrobial treatment.

Discussion: C auris has been a pathogen of increasing nosocomial transmission with particular concern for multidrug resistance. Treatment is with prompt irrigation and debridement and polyethylene exchange and systemic antifungal treatment. Local treatment with antimicrobial impregnated cement can be used to reduce treatment duration and mitigate resistance.

Conclusions: With emerging concerns and the prevalence of infection with C auris, there should be greater vigilance in evaluating patients with repeat surgeries and health care contacts for fungal infection.

导读:2016年,美国疾病控制与预防中心宣布耳念珠菌(C auris)是一种多重耐药真菌,是严重的全球健康威胁。它难以识别,对标准抗真菌治疗具有耐药性,并在卫生保健环境中传播,导致危重患者的高发病率和死亡率。病例介绍:我们报告的情况下,60岁的免疫功能正常的男性与一个漫长的过程假膝关节感染。他在中西部两个州的几家卫生保健机构接受了医疗护理,最终导致伤口裂开和金黄色葡萄球菌感染,需要长期的抗菌治疗。讨论:金黄色葡萄球菌已成为一种日益增加的医院传播病原体,特别是多药耐药。治疗方法为及时冲洗、清创、聚乙烯置换及全身抗真菌治疗。用抗菌浸渍水泥局部处理可缩短治疗时间,减轻耐药性。结论:随着人们的关注和金黄色葡萄球菌感染的流行,在评估重复手术患者和卫生保健接触者真菌感染时应提高警惕。
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引用次数: 0
Service Line Director Appraisal: Evaluating Impact on Provider Satisfaction in a Rural-Based Clinic. 服务线主任评价:评估对农村诊所提供者满意度的影响。
Adedayo Onitilo, Ya-Huei Li, Neel Shimpi, Ingrid Glurich, David Putthoff, Abdul Shour, Heather Bender, William F Melms

Introduction: Rural-based health care systems face unique concerns, including the struggle to recruit and retain quality clinicians. We evaluated health care providers' perceptions of their service line directors (SLDs) in the Marshfield Clinic Health System to understand how these perceptions affect job satisfaction in a rural health care setting.

Methods: Utilizing quantitative and qualitative methods, we reached out to providers within the health system, excluding SLDs to prevent bias. The survey, with a 43% response rate, encompassed 14 questions focusing on 8 domains of engagement. Data analyses included chi-squared tests, t tests, analysis of variance, and correlation matrices. To delve deeper into perceptions, a qualitative approach was employed, analyzing open-ended feedback.

Results: Of the 457 respondents, 70% reported satisfaction with their SLDs. High meeting frequencies with SLDs were positively correlated with satisfaction. The majority acknowledged the positive attributes of SLDs in domains like availability, recognition, and feedback. However, significant variations in perceptions arose between physicians and advanced practice clinicians and between surgeon and non-surgeon SLDs. Qualitative feedback elucidated themes including engagement, communication, and advocacy. Positive attributes, such as competence and proactivity, were mentioned frequently, while negatives highlighted disconnectedness and being uninformed.

Conclusions: The quality of interactions with SLDs significantly influences clinician satisfaction. Regular, meaningful interactions - especially recognizing and providing feedback - enhance satisfaction. However, certain groups like advanced practice clinicians under surgeon SLDs felt less engaged. Our findings underscore the importance of tailored leadership training for SLDs and suggest organizational strategies to boost satisfaction, potentially affecting recruitment and retention in rural health care settings.

以农村为基础的卫生保健系统面临着独特的问题,包括招聘和留住优质临床医生的斗争。我们评估了马什菲尔德诊所卫生系统中卫生保健提供者对其服务线主任(SLDs)的看法,以了解这些看法如何影响农村卫生保健环境中的工作满意度。方法:采用定量和定性方法,我们接触卫生系统内的提供者,排除sld以防止偏见。该调查的回复率为43%,包括14个问题,重点关注8个参与领域。数据分析包括卡方检验、t检验、方差分析和相关矩阵。为了更深入地研究认知,我们采用了定性方法,分析开放式反馈。结果:在457名受访者中,70%的人对他们的SLDs表示满意。高的SLDs会议频率与满意度呈正相关。大多数人都承认sld在可用性、可识别性和反馈等领域的积极属性。然而,在医生和高级临床医生之间以及外科医生和非外科医生之间的认知存在显著差异。定性反馈阐明了包括参与、沟通和倡导在内的主题。积极的属性,如能力和主动性,被频繁提及,而消极的属性则强调了脱节和不知情。结论:与SLDs相互作用的质量显著影响临床医生的满意度。定期的、有意义的互动——尤其是识别和提供反馈——可以提高满意度。然而,某些群体,如外科医生SLDs下的高级临床医生,感觉参与度较低。我们的研究结果强调了为基层医生量身定制领导力培训的重要性,并提出了提高满意度的组织策略,这可能会影响农村卫生保健机构的招聘和保留。
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引用次数: 0
A Case of Travel-Associated Tick-Borne Relapsing Fever in Wisconsin. 威斯康星州一例与旅行有关的蜱传播的回归热。
Michael E Rockman, Zaynab Almothafer, Rylee Doucette, Daniel J Robbins, Michael Scolarici, Manlu Liu, Caitlin S Pepperell, Eduard Matkovic, Jordan Kenik

Introduction: Tick-borne relapsing fever is a zoonotic infection caused by members of the Borrelia genus of spirochetes found predominantly in the southwestern United States.

Case presentation: A 65-year-old woman presented to a Wisconsin emergency department with a 2-day history of fevers and altered mental status after returning from a 5-week stay in Colorado. Initial labs were notable for elevated transaminases, thrombocytopenia, mild hyponatremia, mild hypokalemia, and elevated procalcitonin.

Discussion: Rapid identification of patients with tick-borne relapsing fever is essential to minimize morbidity and mortality. Peripheral blood smear - especially during a febrile episode - can serve as a quick and accurate way to diagnose the illness with direct visualization of spirochetes.

Conclusions: Early analysis of a peripheral blood smear can lead to a swift diagnosis of tick-borne relapsing fever, particularly in nonendemic states such as Wisconsin.

蜱传的回归热是一种人畜共患感染,由主要在美国西南部发现的螺旋体伯氏体属成员引起。病例介绍:一名65岁妇女在科罗拉多州停留5周后返回,因发烧2天和精神状态改变而被送往威斯康星州急诊科。初步实验结果显示转氨酶升高、血小板减少、轻度低钠血症、轻度低钾血症和降钙素原升高。讨论:快速识别蜱传回归热患者对于尽量减少发病率和死亡率至关重要。外周血涂片——特别是在发热期——可作为一种快速准确的方法,通过直接观察螺旋体来诊断该病。结论:早期外周血涂片分析可迅速诊断蜱传回归热,特别是在非流行州,如威斯康星州。
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引用次数: 0
Worsening Epidural Lipomatosis Leading to Foot Drop Following an Epidural Steroid Injection: A Case Report. 硬膜外脂肪增多导致硬膜外类固醇注射后足部下降1例报告。
Ragav Sharma, Sahitya Hari, Hariharan Shankar

Introduction: Epidural lipomatosis is a relatively rare condition resulting in the accumulation of unencapsulated fatty tissue within the epidural space. Steroids, either exogenous or endogenous, have been reported as a cause for this accumulation. The diagnosis is confirmed by computed tomography or magnetic resonance imaging. Symptomatic epidural lipomatosis has been reported to present with radiculopathy, myelopathy, claudication, cauda equina syndrome, or paraplegia. It is usually managed conservatively, including weight loss and avoidance of steroids.

Case presentation: We report the case of a patient with sarcoidosis on oral prednisone who was referred for low back and leg pain of multifactorial origin. After addressing his low back pain, a fluoroscopically guided lumbar epidural steroid injection was performed for his neurogenic claudication. This provided 3 months of complete pain relief. But the patient also developed unilateral foot drop, possibly secondary to worsening epidural lipomatosis.

Conclusions: Epidural lipomatosis may result in complications that include neurological deficits. Although various disease states may cause it, prudence is advised in the use of exogenous steroids.

简介:硬膜外脂肪增多症是一种相对罕见的疾病,它导致硬膜外腔内未包裹的脂肪组织堆积。据报道,外源性或内源性类固醇是导致这种积累的原因。诊断可通过计算机断层扫描或磁共振成像证实。据报道,症状性硬膜外脂肪增多症表现为神经根病、脊髓病、跛行、马尾综合征或截瘫。它通常是保守管理,包括减肥和避免类固醇。病例介绍:我们报告的病例与结节病的病人口服强的松谁被转介腰背部和腿部疼痛的多因素起源。在解决了他的腰痛后,对他的神经源性跛行进行了透视引导下的腰椎硬膜外类固醇注射。这提供了3个月的完全疼痛缓解。但患者也出现单侧足下垂,可能继发于硬膜外脂肪增生症恶化。结论:硬膜外脂肪增生可导致包括神经功能障碍在内的并发症。虽然不同的疾病状态可能导致它,建议谨慎使用外源性类固醇。
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引用次数: 0
Wisconsin Adolescents' Attitudes, Beliefs, Motivations, and Behaviors Surrounding E-Cigarette Use and Cessation. 威斯康辛州青少年对电子烟使用和戒烟的态度、信念、动机和行为
Brian S Williams, Jesse T Kaye, Karen L Conner, Jennifer Bird, Rob Adsit, Megan E Piper

Introduction: Electronic cigarettes (e-cigarettes) are the most common tobacco product used by adolescents, yet no evidence-based cessation treatment for adolescents exists.

Methods: Wisconsin residents aged 13 to 17 (N = 227) completed an online survey assessing e-cigarette use, knowledge, motivations around using and quitting, and recommendations for cessation intervention content.

Results: Most of our sample never vaped (76.2%), reporting concerns with health effects and addiction as motivations preventing initiation. Among adolescents who used e-cigarettes, friend use was the main motivation for initiation, and mental health symptoms promoted ongoing use. Motivations for quitting included health harms, cost, and addiction.

Conclusions: This study identified various topics that motivate and demotivate e-cigarette use among adolescents. This information can be incorporated into prevention and treatment strategies tailored to adolescents.

电子烟(电子烟)是青少年使用的最常见的烟草制品,但目前尚无针对青少年的循证戒烟治疗。方法:威斯康星州13至17岁的居民(N = 227)完成了一项在线调查,评估了电子烟的使用情况、知识、使用和戒烟的动机,以及戒烟干预内容的建议。结果:我们的大多数样本从未吸过电子烟(76.2%),报告担心健康影响和成瘾是阻止开始吸电子烟的动机。在使用电子烟的青少年中,朋友使用是开始使用电子烟的主要动机,心理健康症状促进了持续使用。戒烟的动机包括健康危害、成本和上瘾。结论:本研究确定了激励和抑制青少年使用电子烟的各种主题。这些信息可以纳入针对青少年的预防和治疗战略。
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引用次数: 0
Mind the Gap: Analysis of the Timeline of Medical Readiness and Qualitative Review of Discharge Delays. 注意差距:医疗准备时间线分析和出院延误的定性审查。
Madeleine Nowak, Matthew Bye, Amanda Rogers

Introduction: Efficient discharges lead to decreased length of stay and improved hospital flow. An efficient discharge requires timely recognition of medical readiness for discharge (MRD) and effective preparation. The objective of this study was to better understand pediatric hospital medicine discharges by (1) analyzing the time of MRD and discharge throughout the day, (2) assessing the time from MRD to discharge, and (3) categorizing commonly identified discharge delays.

Methods: A retrospective chart review of pediatric hospital medicine patients with the diagnoses of asthma, "brief resolved unexplained event," hyperbilirubinemia, or "rule out sepsis neonates" was completed. MRD was determined by reviewing the patient's chart for completion of diagnosis-specific discharge criteria. MRD was compared to the time of discharge order and discharge. Delayed discharges were reviewed further to identify reasons for the delay.

Results: One hundred discharge events were analyzed - 25 from each of the 4 selected diagnoses. MRD occurred throughout the day (33% morning, 43% afternoon, 14% evening, and 10% night). The median time from MRD to discharge was 1.7 hours (0.5 hours from MRD to discharge order and 0.9 hours from order to discharge), with the longest MRD to discharge time in asthma patients. Forty percent of patients had a delayed discharge, and identified reasons for delays were further categorized.

Conclusions: MRD occurred throughout the day, suggesting the MRD to discharge time may be an informative metric of discharge efficiency. Next steps include developing forward-facing electronic health record alerts noting MRD for improved tracking and real-time communication and targeted interventions to address reasons for discharge delays.

导言:有效的出院减少了住院时间,提高了医院的流量。有效的出院需要及时识别医疗准备出院(MRD)和有效的准备。本研究的目的是通过(1)分析全天MRD和出院的时间,(2)评估MRD到出院的时间,(3)对常见的出院延误进行分类,更好地了解儿科医院的药物出院情况。方法:对诊断为哮喘、“短暂解决不明原因事件”、高胆红素血症或“排除新生儿败血症”的儿科医院内科患者进行回顾性图表复习。MRD是通过检查患者的病历来确定的,以完成诊断特定的出院标准。将MRD与出院顺序和出院时间进行比较。对延迟放行进行进一步审查,以确定延迟的原因。结果:分析了100例出院事件,4种诊断各25例。MRD发生在全天(上午33%,下午43%,晚上14%,晚上10%)。MRD至出院的中位时间为1.7小时(从MRD至出院令为0.5小时,从出院令至出院令为0.9小时),其中哮喘患者MRD至出院时间最长。40%的患者延迟出院,并确定延迟的原因进一步分类。结论:MRD全天发生,表明MRD与出院时间可能是出院效率的信息指标。接下来的步骤包括开发面向前方的电子健康记录警报,指出MRD,以改进跟踪和实时通信,以及有针对性的干预措施,以解决出院延误的原因。
{"title":"Mind the Gap: Analysis of the Timeline of Medical Readiness and Qualitative Review of Discharge Delays.","authors":"Madeleine Nowak, Matthew Bye, Amanda Rogers","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Efficient discharges lead to decreased length of stay and improved hospital flow. An efficient discharge requires timely recognition of medical readiness for discharge (MRD) and effective preparation. The objective of this study was to better understand pediatric hospital medicine discharges by (1) analyzing the time of MRD and discharge throughout the day, (2) assessing the time from MRD to discharge, and (3) categorizing commonly identified discharge delays.</p><p><strong>Methods: </strong>A retrospective chart review of pediatric hospital medicine patients with the diagnoses of asthma, \"brief resolved unexplained event,\" hyperbilirubinemia, or \"rule out sepsis neonates\" was completed. MRD was determined by reviewing the patient's chart for completion of diagnosis-specific discharge criteria. MRD was compared to the time of discharge order and discharge. Delayed discharges were reviewed further to identify reasons for the delay.</p><p><strong>Results: </strong>One hundred discharge events were analyzed - 25 from each of the 4 selected diagnoses. MRD occurred throughout the day (33% morning, 43% afternoon, 14% evening, and 10% night). The median time from MRD to discharge was 1.7 hours (0.5 hours from MRD to discharge order and 0.9 hours from order to discharge), with the longest MRD to discharge time in asthma patients. Forty percent of patients had a delayed discharge, and identified reasons for delays were further categorized.</p><p><strong>Conclusions: </strong>MRD occurred throughout the day, suggesting the MRD to discharge time may be an informative metric of discharge efficiency. Next steps include developing forward-facing electronic health record alerts noting MRD for improved tracking and real-time communication and targeted interventions to address reasons for discharge delays.</p>","PeriodicalId":94268,"journal":{"name":"WMJ : official publication of the State Medical Society of Wisconsin","volume":"124 2","pages":"96-101"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Violence Against Emergency Department Health Care Workers and the Effect of Wisconsin Act 209. 针对急诊部门医护人员的暴力行为和威斯康星州第209号法案的影响
Lauren Nickel, Corey Sell, Meredith Hiller, Arthur Derse, Nancy Jacobson, Christopher Torkilsen, Jamie Aranda, Bradley Burmeister, Matthew Chinn

Background: Health care settings are not immune to workplace violence, and emergency department workers are especially susceptible. In 2021, Wisconsin Act 209 made it a felony to "intentionally cause bodily harm or threaten to cause bodily harm to a person who works in a health care facility." We conducted a study of emergency department workers to assess their experiences with violence and the perceived effects of Act 209.

Methods: We developed a survey for health care workers (nurses, physicians, and advanced practice providers) who were currently practicing in a Wisconsin emergency department. The reporting timeframe was March 23, 2022, through June 30, 2023.

Results: A total of 194 Wisconsin emergency department workers responded; 70.6% reported experiencing bodily harm, threats of bodily harm, or both. The median number of bodily harm incidents was 2, and 51.4% did not report these incidents. The median number of threats reported was 4, and 66.7% did not report them. Nurses experienced more threats of bodily harm than physicians. Overall, 40.2% of respondents were unaware of Act 209, and 67.6% indicated that abuse toward health care workers occurred at the same rate after its enactment as before. The most frequent barrier to reporting was "Person has a medical condition that might complicate application of the law."

Discussion: Most workers reported experiencing bodily harm or threats, and most did not report these incidents. Beyond clinical factors and time constraints, limited law enforcement bandwidth and perceptions of law enforcement as obstructive were the next most cited barriers. Only 1.2% of respondents reported feeling "definitely safer" after Act 209.

Conclusions: Violence against health care workers has become an expected consequence of working in the field. Legislative action is one tool to attempt to curb this trend. Further efforts to identify strategies that ensure the safety and wellness of health care workers should be a priority.

背景:卫生保健机构也不能幸免于工作场所暴力,急诊科工作人员尤其容易受到影响。2021年,威斯康星州第209号法案将“故意对在医疗机构工作的人造成身体伤害或威胁造成身体伤害”定为重罪。我们对急诊科工作人员进行了一项研究,以评估他们的暴力经历和第209号法案的感知影响。方法:我们对目前在威斯康星州急诊科执业的卫生保健工作者(护士、医生和高级执业提供者)进行了一项调查。报告时间范围为2022年3月23日至2023年6月30日。结果:共有194名威斯康星州急诊科工作人员回应;70.6%的人表示遭受过身体伤害、身体伤害威胁,或两者兼而有之。身体伤害事件的中位数为2,51.4%的人没有报告这些事件。报告的威胁中位数为4,66.7%的人没有报告。护士比医生经历过更多的身体伤害威胁。总体而言,40.2%的答复者不知道第209号法案,67.6%的答复者表示,在该法案颁布后,对卫生保健工作者的虐待发生率与之前相同。报告中最常见的障碍是“当事人有可能使法律适用复杂化的健康状况”。讨论:大多数工人报告经历过身体伤害或威胁,大多数没有报告这些事件。除了临床因素和时间限制之外,有限的执法带宽和认为执法是阻碍的看法是第二常提到的障碍。只有1.2%的受访者表示,在第209号法案之后,他们感到“绝对安全”。结论:针对卫生保健工作者的暴力行为已成为在实地工作的预期后果。立法行动是试图遏制这一趋势的一种工具。应将进一步努力确定确保保健工作者安全和健康的战略作为优先事项。
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引用次数: 0
Navigating the Haze: Delivering Patient-Wanted Care Amidst the Uncertainty of Medical Cannabis. 在阴霾中航行:在医疗大麻的不确定性中提供病人想要的护理。
Michael Chen
{"title":"Navigating the Haze: Delivering Patient-Wanted Care Amidst the Uncertainty of Medical Cannabis.","authors":"Michael Chen","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":94268,"journal":{"name":"WMJ : official publication of the State Medical Society of Wisconsin","volume":"124 5","pages":"409"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145919699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Demographics of Whole-Body Donors in Wisconsin. 威斯康辛州全身捐献者的人口统计。
Sarah Traynor, Christine Egede, Ryan E Hillmer, Scott J Hetzel, Meghan M Cotter

Background: Individuals who donate their bodies to academic, whole-body donation programs support health science education, training, and research. This is the first report on Wisconsin whole-body donor demographics and the extent to which donors represent the state population.

Methods: Donor demographic data from 2016 through 2021 were collected from death certificate worksheets and compared with Wisconsin population data from the US Census Bureau and state health statistics.

Results: Most donors were non-Hispanic White individuals, did not have a college degree, and did not work in health care. The median age at death was 86 years. Twenty-eight percent of donors served in the armed forces. Donors were not representative of the Wisconsin population in age, race, ethnicity, or military service.

Discussion: Whole-body donors provide an invaluable resource for health science education and research. Understanding donor demographics is an important first step in examining diversity and representation within Wisconsin's body donation programs.

背景:将自己的遗体捐赠给学术、全身捐赠项目的个人支持健康科学教育、培训和研究。这是第一份关于威斯康辛州全身捐赠者的人口统计数据以及捐赠者代表该州人口的程度的报告。方法:从死亡证明工作表中收集2016年至2021年的供体人口统计数据,并与美国人口普查局和州卫生统计的威斯康星州人口数据进行比较。结果:大多数捐赠者是非西班牙裔白人,没有大学学位,没有在医疗保健部门工作。死亡年龄中位数为86岁。28%的捐赠者曾在军队服役。捐赠者在年龄、种族、民族或服兵役方面不具有威斯康星州人口的代表性。讨论:全身捐献者为健康科学教育和研究提供了宝贵的资源。了解捐赠者的人口统计数据是检查威斯康星州遗体捐赠计划的多样性和代表性的重要第一步。
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引用次数: 0
Vimkunya - Hope Against Chikungunya: Science, Safety, and Access. 基孔肯雅热的希望:科学、安全和获取。
Muhammad Affan Abid, Ashmat Naqvi, Muhammad Taha Kamal, Muhammad Ali Kamal
{"title":"Vimkunya - Hope Against Chikungunya: Science, Safety, and Access.","authors":"Muhammad Affan Abid, Ashmat Naqvi, Muhammad Taha Kamal, Muhammad Ali Kamal","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":94268,"journal":{"name":"WMJ : official publication of the State Medical Society of Wisconsin","volume":"124 5","pages":"405"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145919720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
WMJ : official publication of the State Medical Society of Wisconsin
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