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I Know How You Feel. 我知道你的感受。
William E Cayley
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引用次数: 0
Subacute Combined Degeneration of the Spinal Cord From Nitrous Oxide Abuse. 一氧化二氮滥用引起的脊髓亚急性合并变性。
Lauren Beranek, Satchel Beranek, Benjamin Kaster

Introduction: The recreational use of nitrous oxide is surging in popularity, with nearly 13 million Americans aged 12 and older reported to have misused it, according to a 2019 survey by the Substance Abuse and Mental Health Services Administration. Prolonged use has been linked to significant neurological deficits, potentially leading to lifelong issues if not treated early.

Case presentation: We present a case of a 38-year-old male with significant neurologic deficits attributed to prolonged nitrous oxide abuse, resulting in subacute combined degeneration of the spinal cord. This condition is characterized by demyelination of dorsal and lateral columns.

Discussion/conclusions: The growing recreational use of nitrous oxide, facilitated by its easy availability and lack of regulation, highlights the importance of clinician vigilance in managing associated risks. Neurological symptoms from vitamin B12 deficiency are particularly worrisome. Early intervention is crucial to prevent potential long-term consequences.

导读:根据美国药物滥用和精神健康服务管理局2019年的一项调查,娱乐性使用一氧化二氮的受欢迎程度正在飙升,据报道,有近1300万12岁及以上的美国人滥用一氧化二氮。长期使用与严重的神经功能缺陷有关,如果不及早治疗,可能导致终身问题。病例介绍:我们提出一个38岁男性的情况下,显著的神经功能缺损归因于长期滥用一氧化二氮,导致亚急性合并脊髓变性。这种情况的特点是背侧柱脱髓鞘。讨论/结论:越来越多的娱乐性使用一氧化二氮,由于其易于获得和缺乏监管,突出了临床医生在管理相关风险方面保持警惕的重要性。维生素B12缺乏引起的神经系统症状尤其令人担忧。早期干预对于预防潜在的长期后果至关重要。
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引用次数: 0
Health Care Workers' Views of Health Care's Contribution to Greenhouse Gas Emissions and Reducing Health Care Emissions. 卫生保健工作者对卫生保健对温室气体排放的贡献和减少卫生保健排放的看法。
Claire Gervais

Introduction: Climate change is the greatest global public health threat of this century, increasing respiratory, cardiovascular, and vector-borne diseases; mental health effects; and premature deaths. The US health care sector is responsible for 8% to 10% of the nation's greenhouse gas emissions; therefore, engaging health care systems in emissions reduction could improve health for all communities.

Methods: A 10-question survey was emailed to a convenience sample consisting of 211 faculty physicians, nurse practitioners, and physician assistants and an unknown number of other staff employed at 21 UW Health family medicine clinics. The survey measured knowledge of health care greenhouse gas emissions and included 2 open-ended questions to solicit opinions on sustainability priorities and barriers to waste reduction. Each clinic also received a 15-minute presentation on health care climate impact during one of their regularly scheduled meetings.

Results: Of the 130 survey respondents, 34% knew the health care sector is responsible for 8% to 10% of the US carbon emissions and 9% of non-greenhouse air pollutants. Only 26% knew that most of these emissions come from purchasing and transportation. However, 92% thought environmental sustainability should be incorporated into all clinical operations, and 74% wanted to know how to affect purchasing to reduce emissions. Top priorities were identified as investing in renewable energy, increasing recycling, and reducing waste (eg, single-use instruments). Top barriers to waste reduction were thought to be cost, complacency, and time.

Conclusions: Despite lack of knowledge of the health care sector's contribution to US greenhouse gas emissions, most surveyed health care workers wanted their health care system to incorporate environmental sustainability into all clinic operations. Additional research identifying knowledge gaps and soliciting opinions of other medical specialties and health care systems on health care greenhouse gas emissions may increase awareness of health care emissions, inform health care leaders, and lead to emissions reduction.

气候变化是本世纪最大的全球公共卫生威胁,增加了呼吸道、心血管和媒介传播疾病;心理健康影响;以及过早死亡。美国医疗保健部门的温室气体排放量占全国温室气体排放量的8%至10%;因此,让卫生保健系统参与减排可以改善所有社区的健康。方法:通过电子邮件向21个华盛顿大学健康家庭医学诊所的211名教员医师、执业护士、医师助理和未知数量的其他工作人员进行了10个问题的调查。该调查衡量了对卫生保健温室气体排放的了解,并包括两个开放式问题,以征求关于可持续性优先事项和减少废物障碍的意见。每家诊所还在定期会议期间听取了关于医疗保健气候影响的15分钟报告。结果:在130名调查对象中,34%的人知道医疗保健行业占美国碳排放量的8%至10%,占非温室气体空气污染物的9%。只有26%的人知道这些排放大部分来自采购和运输。然而,92%的受访者认为环境可持续性应纳入所有临床操作,74%的受访者希望了解如何影响采购以减少排放。最优先事项被确定为投资可再生能源、增加回收利用和减少浪费(例如,一次性仪器)。减少浪费的最大障碍被认为是成本、自满和时间。结论:尽管对卫生保健部门对美国温室气体排放的贡献缺乏了解,但大多数接受调查的卫生保健工作者希望他们的卫生保健系统将环境可持续性纳入所有诊所运营。进一步的研究确定知识差距,并征求其他医学专业和卫生保健系统对卫生保健温室气体排放的意见,可能会提高对卫生保健排放的认识,告知卫生保健领导人,并导致减排。
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引用次数: 0
Prostatic Abscess Presenting as Penile Discharge: A Case Report. 以阴茎分泌物表现的前列腺脓肿1例。
Jenna Wettstein, Whitney Lynch, Mary Beth Graham

Introduction: While prostatic abscess formation is often mitigated by initiating antibiotics for prostatitis, early recognition and treatment are important to avoid risk of sepsis and death.

Case presentation: A 79-year-old male presented with milky-white penile discharge during bowel movements. He had no fever, dysuria, or perineal pain. The discharge culture grew multidrug resistant Escherichia coli. Computed tomography of abdomen/pelvis showed a heterogenous, enlarged prostate leading to diagnosis of a prostatic abscess. The abscess was treated successfully with cystourethroscopy, transurethral unroofing, and a course of intravenous ertapenem.

Discussion: Previous research shows patients with prostatic abscesses present with perineal pain, dysuria, and fever. This case demonstrates the importance of considering a prostatic abscess in a patient with penile discharge alone.

Conclusions: We report a unique presentation of prostate abscess to educate and improve clinical suspicion of a rare, yet potentially fatal urological complication.

导言:虽然前列腺脓肿的形成通常可以通过前列腺炎的抗生素治疗来缓解,但早期识别和治疗对于避免败血症和死亡的风险非常重要。病例介绍:一名79岁男性,排便时出现乳白色阴茎分泌物。他没有发烧、排尿困难或会阴疼痛。排出培养培养出耐多药大肠杆菌。腹部/骨盆电脑断层显示前列腺肿大,诊断为前列腺脓肿。通过膀胱尿道镜检查、经尿道开颅和静脉注射厄他培南治疗脓肿成功。讨论:既往研究显示前列腺脓肿患者表现为会阴疼痛、排尿困难和发热。本病例表明考虑前列腺脓肿的重要性,在病人的阴茎分泌物单独。结论:我们报告一个独特的前列腺脓肿的表现,以教育和提高临床怀疑罕见的,但潜在致命的泌尿系统并发症。
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引用次数: 0
Exploring Health Care Barriers for the Unhoused: Insights from a Rural Midwestern Community. 为无家可归者探索医疗保健障碍:来自中西部农村社区的见解。
Reilly A Coombs, Payton Jorgenson, Corina Norrbom, Amy Prunuske

Introduction: People experiencing homelessness are more likely than the general population to have chronic health conditions and often encounter significant barriers to health care access. Many of these barriers can be affected by community-based factors, such as availability of reliable transportation, past experiences with health care systems, and community attitudes toward the unhoused population. This project aims to assess the needs and barriers to health care identified by people experiencing homelessness in a rural Midwestern city.

Methods: The survey used was adapted from a survey previously conducted to assess the needs of the homeless population in Milwaukee, Wisconsin. Surveys were distributed during outreach around the city of Wausau, Wisconsin. Data were transcribed and reviewed, and descriptive statistics were calculated.

Results: A total of 45 surveys were completed. Most participants identified as White, non-Hispanic males (n = 24, 53%) and were 46 to 55 years old (n = 14, 31%). Barriers to health care included lack of housing, cost, transportation, lack of a mailing address, inadequate hours, and disrespectful care. Eighty-six percent of participants (n = 38) reported having a mental health diagnosis, yet only 26% (n = 12) stated that they see a mental health professional.

Conclusions: Individuals experiencing homelessness in a rural community have broad and complex barriers to accessing health care. Given limited resources in smaller communities, innovative and holistic solutions should be considered when aiming to make care more equitable.

导言:无家可归者比一般人更有可能患有慢性疾病,而且往往在获得保健服务方面遇到重大障碍。其中许多障碍可能受到社区因素的影响,例如是否有可靠的交通工具、过去使用卫生保健系统的经验以及社区对无家可归人口的态度。该项目旨在评估中西部一个农村城市无家可归者确定的保健需求和障碍。方法:使用的调查改编自先前进行的调查,以评估威斯康星州密尔沃基市无家可归者的需求。调查是在威斯康辛州沃索市的外展期间分发的。对数据进行转录和审查,并进行描述性统计。结果:共完成问卷调查45份。大多数参与者被确定为白人,非西班牙裔男性(n = 24, 53%),年龄在46至55岁(n = 14, 31%)。获得医疗保健的障碍包括缺乏住房、费用、交通、缺乏邮寄地址、工作时间不足以及不尊重的护理。86%的参与者(n = 38)报告有心理健康诊断,但只有26% (n = 12)的人表示他们看过心理健康专家。结论:农村社区无家可归者在获得医疗保健方面存在广泛而复杂的障碍。鉴于较小社区的资源有限,在力求使护理更加公平时,应考虑采用创新和全面的解决办法。
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引用次数: 0
Unilateral, Episodic, Transient Blanching of Nipple With Pain in a Male: A Case Report. 男性单侧、发作性、短暂性乳头发热伴疼痛1例报告。
Marisol Rodriguez, Hariharan Shankar

Introduction: Causes of nipple pain include trauma, vasospasm, malignancy, Paget's disease, inflammation secondary to blockage of the ducts, infection, and medications. Raynaud's phenomenon (RP) of the nipple is reported more often in women and typically presents bilaterally.

Case presentation: A 63-year-old man presented with episodic, stabbing pain and blanching of the left nipple, worsening over 3 years. Symptoms began insidiously during military service. Examination revealed no abnormalities, but blanching was observed during a painful episode. Laboratory and imaging studies were unremarkable. Conservative measures and pharmacologic agents, including nitroglycerin ointment and amlodipine, provided minimal relief. Intercostal nerve blocks and cervical sympathetic blocks did not provide lasting relief. Ultrasound-guided paravertebral sympathetic block with local anesthetic provided temporary relief lasting week. Botulinum toxin injection around the areola resulted in sustained pain relief lasting more than month.

Discussion: The patient's presentation is consistent with primary RP of the nipple, a rare and underrecognized condition. While it typically affects distal extremities, it can involve other areas, including the nipple. Diagnosis is clinical, often requiring documentation during episodes. Management is challenging and largely anecdotal. Botulinum toxin has shown promise in RP, though evidence remains mixed.

Conclusions: This case highlights a rare presentation of unilateral, vasospastic nipple pain resembling primary RP, with partial response to botulinum toxin injection.

乳头疼痛的原因包括创伤、血管痉挛、恶性肿瘤、佩吉特病、继发于导管阻塞的炎症、感染和药物治疗。乳头雷诺现象(RP)在女性中更为常见,通常表现为双侧乳头。病例介绍:一名63岁男性,表现为发作性,刺痛和左乳头发白,病情恶化超过3年。在服兵役期间,症状开始悄然出现。检查未发现异常,但在疼痛发作期间观察到发热。实验室和影像学检查无显著差异。保守措施和药物治疗,包括硝酸甘油软膏和氨氯地平,提供了最小的缓解。肋间神经阻滞和颈交感神经阻滞不能提供持久的缓解。超声引导椎旁交感神经阻滞加局麻药可提供持续一周的暂时性缓解。乳晕周围注射肉毒杆菌毒素使疼痛持续缓解了一个多月。讨论:患者的表现与乳头原发性RP一致,这是一种罕见且未被充分认识的疾病。虽然它通常影响远端肢体,但也可能涉及其他部位,包括乳头。诊断是临床的,通常需要在发作时记录。管理是具有挑战性的,而且大多是轶事。肉毒杆菌毒素在RP中显示出希望,尽管证据仍然混杂。结论:本病例表现为罕见的单侧、血管痉挛性乳头疼痛,类似原发性RP,对肉毒毒素注射有部分反应。
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引用次数: 0
Sarcoidosis Masquerading as Breast Implant- Associated Anaplastic Large Cell Lymphoma -  The Importance of Definitive Pathology to Guide Therapy. 结节病伪装成乳房假体相关间变性大细胞淋巴瘤-明确病理指导治疗的重要性。
Riley Young, Emelyn Zaworski, Melissa Hart, Bradley Grewe, Ellen Liang, Yvonne Pierpont

Introduction: Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare critical outcome of breast implantation that typically presents 8 to 10 years after textured-implant placement with periprosthetic seroma. Treatment consists of implant removal and capsulectomy, which is typically curative. But in rare case, malignant infiltration through the capsule results in disseminated disease, necessitating aggressive treatment with systemic chemotherapy. Sarcoidosis, a chronic systemic granulomatous disease characterized by noncaseating granulomas, is another rare cause of periprosthetic seroma.

Case presentation: A 61-year-old female with a history of invasive ductal carcinoma of the breast status post textured implant-based reconstruction presented with late periprosthetic seroma and overlying rash. Cytology of seroma aspirate was suggestive of BIA-ALCL, and positron emission tomography-computed tomography was concerning for invasive disease. Surgical specimen pathology of the implant-capsule complex and skin punch biopsy of the overlying rash revealed only granulomatous inflammation. The patient was diagnosed with sarcoidosis and spared systemic chemotherapy treatment for disseminated BIA-ALCL.

Conclusions: BIA-ALCL should be ruled out in all cases of late periprosthetic seroma. Definitive surgical pathology is necessary to prevent misdiagnosis and inappropriate treatment of masquerading entities, such as sarcoidosis.

导语:乳房植入相关间变性大细胞淋巴瘤(BIA-ALCL)是一种罕见的乳房植入的关键结果,通常出现在有纹理的植入后8至10年假体周围血清肿。治疗包括种植体移除和囊切除术,这通常是治愈的。但在极少数情况下,恶性浸润通过囊导致播散性疾病,需要积极的治疗与全身化疗。结节病是一种慢性系统性肉芽肿性疾病,以非干酪化肉芽肿为特征,是另一种罕见的假体周围血肿病因。病例介绍:一名61岁女性,有浸润性乳腺导管癌病史,假体重建后表现为晚期假体周围血肿和上覆皮疹。吸出性血肿细胞学提示BIA-ALCL,正电子发射断层扫描-计算机断层扫描关注侵袭性疾病。植体-包膜复合体的手术标本病理和上覆皮疹的皮肤穿刺活检显示只有肉芽肿性炎症。患者被诊断为结节病,并因弥漫性BIA-ALCL而免于全身化疗。结论:所有晚期假体周围血肿病例均应排除BIA-ALCL。明确的手术病理是必要的,以防止误诊和不适当的治疗伪装实体,如结节病。
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引用次数: 0
Comment on 'Enhancing Diagnosis of Obstructive Lung Diseases: Insights From Clinical Characteristics in a Prospective Cohort Study'. “增强阻塞性肺疾病的诊断:来自前瞻性队列研究临床特征的见解”
Rachana Mehta, Ranjana Sah, Shubham Kumar
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引用次数: 0
Prevention Through Partnerships: Empowering Parent-Child Discussions About the Risk of Alcohol and Cancer. 通过伙伴关系进行预防:加强亲子讨论酒精和癌症风险的能力。
Catherine McCall, Allison Antoine, Sarah Kerch, Joshua Skowron, Noelle K LoConte

Background: Alcohol use is increasing in Wisconsin. We aimed to improve a state public health campaign around youth drinking to increase awareness of alcohol as a carcinogen.

Methods: The campaign was expanded and distributed via targeted social media advertisements and a directed campaign in a Wisconsin county with high rates of alcohol consumption.

Results: The media campaign outperformed benchmarks by 23.6%, delivering 1.65 million impressions. Total billboard impressions exceeded expectations by 46%. Across all digital tactics, there was a collective click-through rate of 0.42%. Facebook had the largest audience with over 128 000 total impressions, exceeding expectations by 28%. Cancer-specific related messaging engaged slightly higher click-through rates among Facebook audiences than impact messaging (0.47% vs 0.36%).

Discussion: Adding cancer-related messaging was effective in this expanded Wisconsin state youth drinking campaign.

背景:威斯康星州的酒精使用正在增加。我们的目标是改善围绕青少年饮酒的州公共卫生运动,以提高人们对酒精致癌物质的认识。方法:该活动通过有针对性的社交媒体广告和威斯康星州一个酒精消费量高的县的定向活动来扩大和分发。结果:此次媒体宣传活动的曝光量超过基准23.6%,达到165万次。广告牌的总印象超过预期46%。在所有数字策略中,总点击率为0.42%。Facebook拥有最多的用户,总印象数超过12.8万次,超出预期28%。与癌症相关的消息在Facebook用户中的点击率略高于影响消息(0.47% vs 0.36%)。讨论:在这个扩大的威斯康星州青少年饮酒运动中,增加与癌症相关的信息是有效的。
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引用次数: 0
Exploration of Factors That Positively Influence Medical Student Reception of Question-Based Teaching in Clinical Settings. 临床医学生接受问题型教学的积极影响因素探讨。
Asha S Jain, Jacob J Abou-Hanna, Elizabeth M Petty

Introduction: Academic medicine literature has reported hesitation from clinical teaching physicians to use questions when teaching medical students due to its negative connotation of "pimping." However, newer literature suggests that most students prefer questions, while only a small minority are less welcoming. Some teaching physicians, however, have concerns about using questions due to the risk of humiliating or embarrassing medical students in clinical settings.

Methods: Medical students who completed core clerkship rotations at a public medical school in the Midwest were invited to participate in 1 of 4 virtual focus groups. Students were asked to reflect on 3 clinical teaching vignettes. Inductive thematic qualitative analysis was performed to create a codebook. The transcripts were coded by 2 independent coders for emerging themes.

Results: Twenty-six students participated across 4 groups. Four major themes were identified that demonstrate positive student reception of teaching physicians and their questions: teaching physicians (1) engaging students, (2) setting clear expectations, (3) empathizing with the medical student experience, and (4) asking questions to teach rather than evaluate. Thematic coding of the 3 vignettes resulted in initial intercoder reliabilities of 85.4%, 87%, and 79%, prior to achieving 100% consensus. Students described the ideal teaching physician to be patient, engaged, and respectful.

Conclusions: By engaging medical students, setting clear expectations early on, empathizing with the medical student experience, and asking questions with the purpose of teaching, teaching physicians can be less hesitant about upsetting medical students when utilizing questions as a teaching tool.

导读:学术医学文献报道了临床教学医生在教授医学生时使用问题的犹豫,因为它具有“拉皮条”的负面含义。然而,最新的文献表明,大多数学生更喜欢提问,而只有一小部分人不太欢迎。然而,一些教学医生担心在临床环境中使用问题会使医学生感到羞辱或尴尬。方法:邀请在中西部一所公立医学院完成核心见习轮转的医学生参加4个虚拟焦点小组中的1个。学生被要求反思3个临床教学小插曲。进行归纳专题定性分析,创建一个密码本。脚本由2个独立的编码员针对新兴主题进行编码。结果:26名学生分4组参与。确定了四个主要主题,表明学生对教学医生及其问题的积极接受:教学医生(1)吸引学生,(2)设定明确的期望,(3)对医学生的经历感同身受,(4)提出问题以教学而不是评估。在达到100%的共识之前,对3个小片段进行主题编码的初始互编码可靠性分别为85.4%、87%和79%。学生们描述了理想的教学医生是耐心、敬业和尊重。结论:通过吸引医学生,尽早设定明确的期望,对医学生的经历感同身受,并以教学为目的提出问题,教学医生在利用问题作为教学工具时,可以更少地犹豫是否会让医学生感到不安。
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引用次数: 0
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WMJ : official publication of the State Medical Society of Wisconsin
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