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Breast Mass Detection and Classification Using Machine Learning Approaches on Two-Dimensional Mammogram: A Review. 使用机器学习方法在二维乳房 X 光照片上检测乳房肿块并进行分类:综述。
Pub Date : 2024-01-01 DOI: 10.1615/CritRevBiomedEng.2024051166
N Shankari, Vidya Kudva, Roopa B Hegde

Breast cancer is a leading cause of mortality among women, both in India and globally. The prevalence of breast masses is notably common in women aged 20 to 60. These breast masses are classified, according to the breast imaging-reporting and data systems (BI-RADS) standard, into categories such as fibroadenoma, breast cysts, benign, and malignant masses. To aid in the diagnosis of breast disorders, imaging plays a vital role, with mammography being the most widely used modality for detecting breast abnormalities over the years. However, the process of identifying breast diseases through mammograms can be time-consuming, requiring experienced radiologists to review a significant volume of images. Early detection of breast masses is crucial for effective disease management, ultimately reducing mortality rates. To address this challenge, advancements in image processing techniques, specifically utilizing artificial intelligence (AI) and machine learning (ML), have tiled the way for the development of decision support systems. These systems assist radiologists in the accurate identification and classification of breast disorders. This paper presents a review of various studies where diverse machine learning approaches have been applied to digital mammograms. These approaches aim to identify breast masses and classify them into distinct subclasses such as normal, benign and malignant. Additionally, the paper highlights both the advantages and limitations of existing techniques, offering valuable insights for the benefit of future research endeavors in this critical area of medical imaging and breast health.

无论在印度还是在全球,乳腺癌都是妇女死亡的主要原因。乳房肿块在 20 至 60 岁的女性中尤为常见。根据乳腺成像报告和数据系统(BI-RADS)标准,这些乳腺肿块可分为纤维腺瘤、乳腺囊肿、良性肿块和恶性肿块等类别。为了帮助诊断乳腺疾病,影像学起着至关重要的作用,多年来,乳房 X 线照相术是检测乳腺异常最广泛使用的方式。然而,通过乳房 X 光检查确定乳腺疾病的过程非常耗时,需要经验丰富的放射科医生查看大量图像。早期发现乳腺肿块对于有效控制疾病、最终降低死亡率至关重要。为了应对这一挑战,图像处理技术的进步,特别是人工智能(AI)和机器学习(ML)的应用,为决策支持系统的开发铺平了道路。这些系统可帮助放射科医生准确识别乳腺疾病并进行分类。本文回顾了将各种机器学习方法应用于数字乳房 X 光照片的各种研究。这些方法旨在识别乳腺肿块,并将其分为不同的子类,如正常、良性和恶性。此外,本文还强调了现有技术的优势和局限性,为医学成像和乳腺健康这一关键领域的未来研究工作提供了宝贵的见解。
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引用次数: 0
Ion-Induced Swelling Behavior of Articular Cartilage due to Non-Newtonian Flow and Its Effects on Fluid Pressure and Solid Displacement. 非牛顿流引起的关节软骨离子诱导膨胀行为及其对流体压力和固体位移的影响
Pub Date : 2024-01-01 DOI: 10.1615/CritRevBiomedEng.2024051586
J I Siddique, Umair Farooq, Usman Ali, Aftab Ahmed

In this study, we examine the behavior of articular cartilage equilibrated in a salt (NaCl) solution during non-Newtonian fluid flow that follows an Ostwald-de Waele model. A linearly elastic and isotropic rectangular strip of cartilage is considered for analysis. A continuum theory of mixtures has been employed to develop a coupled system of partial differential equations for the solid displacement and the fluid pressure by considering the important factor of the ion concentration by assuming the cartilage as a deformable porous media. The coupled system of partial differential equations is solved using the numerical method named method of lines. In most cases, shear-thinning fluid is compared to the shear-thickening fluid to magnify the difference. Graphical results show that shear-thickening fluids bring more solid deformation and shows less fluid pressure in comparison to the shear-thinning fluids.

在这项研究中,我们按照奥斯特瓦尔德-德韦勒模型,研究了在盐(NaCl)溶液中平衡的关节软骨在非牛顿流体流动过程中的行为。分析考虑的是线性弹性和各向同性的矩形软骨条。假设软骨为可变形的多孔介质,考虑到离子浓度这一重要因素,采用混合物连续理论建立了固体位移和流体压力的偏微分方程耦合系统。该耦合偏微分方程系采用名为线性法的数值方法求解。在大多数情况下,将剪切稀化流体与剪切增稠流体进行比较以放大差异。图形结果表明,与剪切稀化流体相比,剪切增稠流体带来的固体变形更大,流体压力更小。
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引用次数: 0
Fuzzy-Based Bioengineering System for Predicting and Diagnosing Diseases of the Nervous System Triggered by the Interaction of Industrial Frequency Electromagnetic Fields. 基于模糊的生物工程系统,用于预测和诊断工业频率电磁场相互作用引发的神经系统疾病。
Pub Date : 2024-01-01 DOI: 10.1615/CritRevBiomedEng.2024053240
Nikolay Aleexevich Korenevskiy, Riad Taha Al-Kasasbeh, Evgenia A Krikunova, Sofia N Rodionova, Ashraf Shaqdan, Osama M Al-Habahbeh, Sergey Filist, Mahdi Salman Alshamasin, Mohammad S Khrisat, Maksim Ilyash

The study aims to enhance the standard of medical care for individuals working in the electric power industry who are exposed to industrial frequency electromagnetic fields and other relevant risk factors. This enhancement is sought through the integration of fuzzy mathematical models with contemporary information and intellectual technologies. The study addresses the challenges of forecasting and diagnosing illnesses within a specific demographic characterized by a combination of poorly formalized issues with interconnected conditions. To tackle this complexity, a methodological framework was developed for synthesizing hybrid fuzzy decision rules. This approach combines clinical expertise with artificial intelligence methodologies to promote innovative problem-solving strategies. Additionally, the researchers devised an original method to evaluate the body's protective capacity, which was integrated into these decision rules to enhance the precision and efficacy of medical decision-making processes. The research findings indicate that industrial frequency electromagnetic fields contribute to illnesses of societal significance. Additionally, it highlights that these effects are worsened by other risk factors such as adverse microclimates, noise, vibration, chemical exposure, and psychological stress. Diseases of the neurological, immunological, cardiovascular, genitourinary, respiratory, and digestive systems are caused by these variables in conjunction with unique physical traits. The development of mathematical models in this study makes it possible to detect and diagnose disorders in workers exposed to electromagnetic fields early on, especially those pertaining to the autonomic nervous system and heart rhythm regulation. The results can be used in clinical practice to treat personnel in the electric power industry since expert evaluation and modeling showed high confidence levels in decision-making accuracy.

本研究旨在提高对在电力行业工作、暴露于工频电磁场和其他相关风险因素的人员的医疗保健水平。这种提高是通过将模糊数学模型与当代信息和智能技术相结合来实现的。这项研究解决了在特定人群中预测和诊断疾病所面临的挑战,该人群的特点是将形式化程度低的问题与相互关联的条件结合在一起。为解决这一复杂问题,研究人员开发了一个方法框架,用于综合混合模糊决策规则。这种方法将临床专业知识与人工智能方法相结合,以促进创新的问题解决策略。此外,研究人员还设计了一种评估人体保护能力的原创方法,并将其融入这些决策规则中,以提高医疗决策过程的精确性和有效性。研究结果表明,工频电磁场会导致具有社会意义的疾病。此外,研究还强调,不利的微气候、噪音、振动、化学接触和心理压力等其他风险因素也会加剧这些影响。神经系统、免疫系统、心血管系统、泌尿生殖系统、呼吸系统和消化系统的疾病都是由这些变量与独特的身体特征共同造成的。在这项研究中建立数学模型,可以及早发现和诊断暴露在电磁场中的工人的疾病,尤其是与自律神经系统和心律调节有关的疾病。由于专家评估和建模显示决策准确性的置信度较高,因此研究结果可用于临床实践,为电力行业人员提供治疗。
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引用次数: 0
Research on Medical Image Segmentation Method Based on Improved U-Net3. 基于改进型 U-Net 的医学图像分割方法研究3。
Pub Date : 2024-01-01 DOI: 10.1615/CritRevBiomedEng.2024052258
Chaoying Wang, Jianxin Li, Huijun Zheng, Jiajun Li, Hongxing Huang, Lai Jiang

Computer assisted diagnostic technology has been widely used in clinical practice, specifically focusing on medical image segmentation. Its purpose is to segment targets with certain special meanings in medical images and extract relevant features, providing reliable basis for subsequent clinical diagnosis and research. However, because of different shapes and complex structures of segmentation targets in different medical images, some imaging techniques have similar characteristics, such as intensity, color, or texture, for imaging different organs and tissues. The localization and segmentation of targets in medical images remains an urgent technical challenge to be solved. As such, an improved full scale skip connection network structure for the CT liver image segmentation task is proposed. This structure includes a biomimetic attention module between the shallow encoder and the deep decoder, and the feature fusion proportion coefficient between the two is learned to enhance the attention of the overall network to the segmented target area. In addition, based on the traditional point sampling mechanism, an improved point sampling strategy is proposed for characterizing medical images to further enhance the edge segmentation effect of CT liver targets. The experimental results on the commonly used combined (CT-MR) health absolute organ segmentation (CHAOS) dataset show that the average dice similarity coefficient (DSC) can reach 0.9467, the average intersection over union (IOU) can reach 0.9623, and the average F1 score can reach 0.9351. This indicates that the model can effectively learn image detail features and global structural features, leading to improved segmentation of liver images.

计算机辅助诊断技术已被广泛应用于临床实践,尤其侧重于医学影像分割。其目的是对医学影像中具有某些特殊意义的目标进行分割,提取相关特征,为后续的临床诊断和研究提供可靠依据。然而,由于不同医学图像中的分割目标形状各异、结构复杂,有些成像技术对不同器官和组织的成像具有相似的特征,如强度、颜色或纹理等。医疗图像中目标的定位和分割仍然是亟待解决的技术难题。因此,针对 CT 肝脏图像分割任务,提出了一种改进的全尺度跳转连接网络结构。该结构包括浅层编码器和深层解码器之间的仿生物注意力模块,并学习两者之间的特征融合比例系数,以增强整个网络对分割目标区域的注意力。此外,在传统点采样机制的基础上,提出了一种改进的医疗图像特征点采样策略,以进一步增强 CT 肝脏靶标的边缘分割效果。在常用的联合(CT-MR)健康绝对器官分割(CHAOS)数据集上的实验结果表明,平均骰子相似系数(DSC)可达 0.9467,平均交集大于联合(IOU)可达 0.9623,平均 F1 分数可达 0.9351。这表明该模型能有效地学习图像细节特征和全局结构特征,从而改进肝脏图像的分割。
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引用次数: 0
Correlation Attention Registration Based on Deep Learning from Histopathology to MRI of Prostate. 基于深度学习的组织病理学与前列腺 MRI 的相关性注意登记。
Pub Date : 2024-01-01 DOI: 10.1615/CritRevBiomedEng.2023050566
Xue Wang, Zhili Song, Jianlin Zhu, Zhixiang Li

Deep learning offers a promising methodology for the registration of prostate cancer images from histopathology to MRI. We explored how to effectively leverage key information from images to achieve improved end-to-end registration. We developed an approach based on a correlation attention registration framework to register segmentation labels of histopathology onto MRI. The network was trained using paired prostate datasets of histopathology and MRI from the Cancer Imaging Archive. We introduced An L2-Pearson correlation layer to enhance feature matching. Furthermore, our model employed an enhanced attention regression network to distinguish between key and nonkey features. For data analysis, we used the Kolmogorov-Smirnov test and a one-sample t-test, with the statistical significance level for the one-sample t-test set at 0.001. Compared with two other models (ProsRegNet and CNNGeo), our model exhibited improved performance in Dice coefficient, with increases of 9.893% and 2.753%, respectively. The Hausdorff distance was reduced by approximately 50% and 50%, while the average label error (ALE) was reduced by 0.389% and 15.021%. The proposed improved multimodal prostate registration framework demonstrated high performance in statistical analysis. The results indicate that our enhanced strategy significantly improves registration performance and enables faster registration of histopathological images of patients undergoing radical prostatectomy to preoperative MRI. More accurate registration can prevent over-diagnosing low-risk cancers and frequent false positives due to observer differences.

深度学习为前列腺癌图像从组织病理学到核磁共振成像的配准提供了一种前景广阔的方法。我们探索了如何有效利用图像中的关键信息来实现更好的端到端配准。我们开发了一种基于相关注意配准框架的方法,将组织病理学的分割标签配准到核磁共振成像上。我们使用癌症成像档案中组织病理学和核磁共振成像的配对前列腺数据集对网络进行了训练。我们引入了 L2-Pearson 关联层来增强特征匹配。此外,我们的模型还采用了增强型注意力回归网络来区分关键特征和非关键特征。在数据分析中,我们使用了 Kolmogorov-Smirnov 检验和单样本 t 检验,单样本 t 检验的统计显著性水平设定为 0.001。与其他两个模型(ProsRegNet 和 CNNGeo)相比,我们的模型在骰子系数方面表现更好,分别提高了 9.893% 和 2.753%。豪斯多夫距离(Hausdorff distance)分别降低了约 50%和 50%,平均标签误差(ALE)分别降低了 0.389% 和 15.021%。所提出的改进型多模态前列腺配准框架在统计分析中表现出很高的性能。结果表明,我们的增强型策略显著提高了配准性能,使接受根治性前列腺切除术的患者的组织病理学图像与术前磁共振成像的配准速度更快。更精确的配准可避免过度诊断低风险癌症和因观察者差异而导致的频繁假阳性。
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引用次数: 0
An Ensemble Model Health Care Monitoring System. 集合模型医疗监控系统
Pub Date : 2024-01-01 DOI: 10.1615/CritRevBiomedEng.2024049488
Hariprasad Anumala

Internet of things (IoT) is utilized to enhance conventional health care systems in several ways, including patient's disease monitoring. The data gathered by IoT devices is very beneficial to medical facilities and patients. The data needs to be secured against unauthorized modifications because of security and privacy concerns. Conversely, a variety of procedures are offered by block chain technology to safeguard data against modifications. Block chain-based IoT-based health care monitoring is thus a fascinating technical advancement that may aid in easing security and privacy problems associated withthe collection of data during patient monitoring. In this work, we present an ensemble classification-based monitoring system with a block-chain as the foundation for an IoT health care model. Initially, data generation is done by considering the diseases including chronic obstructive pulmonary disease (COPD), lung cancer, and heart disease. The IoT health care data is then preprocessed using enhanced scalar normalization. The preprocessed data was used to extract features such as mutual information (MI), statistical features, adjusted entropy, and raw features. The total classified result is obtained by averaging deep maxout, improved deep convolutional network (IDCNN), and deep belief network (DBN) ensemble classification. Finally, decision-making is done by doctors to suggest treatment based on the classified results from the ensemble classifier. The ensemble model scored the greatest accuracy (95.56%) with accurate disease classification at a learning percentage of 60% compared to traditional classifiers such as neural network (NN) (89.08%), long short term memory (LSTM) (80.63%), deep belief network (DBN) (79.78%) and GT based BSS algorithm (89.08%).

物联网(IoT)在多个方面被用来增强传统的医疗保健系统,包括病人的疾病监测。物联网设备收集的数据对医疗机构和患者都非常有益。出于安全和隐私方面的考虑,需要确保数据不被擅自修改。相反,区块链技术提供了各种程序来保护数据不被修改。因此,基于区块链的物联网医疗监控是一项引人入胜的技术进步,可帮助缓解患者监控过程中与数据收集相关的安全和隐私问题。在这项工作中,我们提出了一种基于集合分类的监控系统,并将区块链作为物联网医疗保健模型的基础。首先,通过考虑慢性阻塞性肺病(COPD)、肺癌和心脏病等疾病来生成数据。然后,使用增强标量标准化对物联网健康护理数据进行预处理。预处理后的数据用于提取互信息(MI)、统计特征、调整熵和原始特征等特征。通过平均深度最大值、改进的深度卷积网络(IDCNN)和深度信念网络(DBN)的集合分类,得到总的分类结果。最后,医生根据集合分类器的分类结果提出治疗建议。与神经网络(NN)(89.08%)、长短期记忆(LSTM)(80.63%)、深度信念网络(DBN)(79.78%)和基于 GT 的 BSS 算法(89.08%)等传统分类器相比,集合模型的准确率最高(95.56%),疾病分类准确率为 60%。
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引用次数: 0
Transformer-Based Network for Accurate Classification of Lung Auscultation Sounds. 基于变压器的肺部听诊声音精确分类网络。
Pub Date : 2023-01-01 DOI: 10.1615/CritRevBiomedEng.2023048981
C S Sonali, John Kiran, B S Chinmayi, K V Suma, Muhammad Easa

Respiratory diseases are a major cause of death worldwide, affecting a significant proportion of the population with lung function abnormalities that can lead to respiratory illnesses. Early detection and prevention are critical to effective management of these disorders. Deep learning algorithms offer a promising approach for analyzing complex medical data and aiding in early disease detection. While transformer-based models for sequence classification have proven effective for tasks like sentiment analysis, topic classification, etc., their potential for respiratory disease classification remains largely unexplored. This paper proposes a classifier utilizing the transformer-encoder block, which can capture complex patterns and dependencies in medical data. The proposed model is trained and evaluated on a large dataset from the International Conference on Biomedical Health Informatics 2017, achieving state-of-the-art results with a mean sensitivity of 70.53%, mean specificity of 84.10%, mean average score of 77.32%, and mean harmonic score of 76.10%. These results demonstrate the model's effectiveness in diagnosing respiratory diseases while taking up minimal computational resources.

呼吸系统疾病是世界范围内死亡的主要原因,影响着相当大比例的肺功能异常人群,而肺功能异常可能导致呼吸系统疾病。早期发现和预防对于有效管理这些疾病至关重要。深度学习算法为分析复杂的医学数据和帮助早期疾病检测提供了一种很有前途的方法。虽然基于变换器的序列分类模型已被证明对情感分析、主题分类等任务有效,但它们在呼吸道疾病分类方面的潜力在很大程度上仍未被探索。本文提出了一种利用转换器-编码器块的分类器,该分类器可以捕获医学数据中的复杂模式和依赖关系。所提出的模型在2017年国际生物医学健康信息学会议的大型数据集上进行了训练和评估,取得了最先进的结果,平均灵敏度为70.53%,平均特异性为84.10%,平均得分为77.32%,平均谐波得分为76.10%。这些结果证明了该模型在诊断呼吸道疾病方面的有效性,同时占用了最少的计算资源。
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引用次数: 0
Review of Enhanced Handheld Surgical Drills. 增强型手持式手术钻头综述。
Pub Date : 2023-01-01 DOI: 10.1615/CritRevBiomedEng.2023049106
David E Usevitch, Rachel S Bronheim, Miguel A Cartagena-Reyes, Carlos Ortiz-Babilonia, Adam Margalit, Amit Jain, Mehran Armand

The handheld drill has been used as a conventional surgical tool for centuries. Alongside the recent successes of surgical robots, the development of new and enhanced medical drills has improved surgeon ability without requiring the high cost and consuming setup times that plague medical robot systems. This work provides an overview of enhanced handheld surgical drill research focusing on systems that include some form of image guidance and do not require additional hardware that physically supports or guides drilling. Drilling is reviewed by main contribution divided into audio-, visual-, or hardware-enhanced drills. A vision for future work to enhance handheld drilling systems is also discussed.

手持钻头作为传统的外科手术工具已经使用了几个世纪。除了最近手术机器人的成功之外,新型和增强型医疗钻机的开发提高了外科医生的能力,而不需要困扰医疗机器人系统的高成本和耗时的设置时间。这项工作概述了增强型手持式手术钻头的研究,重点是包括某种形式的图像引导的系统,并且不需要物理支持或引导钻孔的额外硬件。钻井按主要贡献进行审查,分为音频、视觉或硬件增强型钻井。还讨论了增强手持式钻井系统的未来工作愿景。
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引用次数: 0
Test and Development of a Specialized Pipeline for Ventilator Calibration. 呼吸机校准专用管路的测试与开发。
Pub Date : 2023-01-01 DOI: 10.1615/CritRevBiomedEng.2023048365
Junming Liu, Wenxiu Zheng, Ziyan Wang

A specialized Y-type pipeline is developed to replace medical disposable Y-type pipelines for ventilator calibration and to improve accuracy, providing a reference for improvement. According to the calibration specifications of ventilators, tests are performed on specialized pipelines and more to compare their data. Taking the tidal volume 400-mL detection point as an example, the calibration errors made by medical disposable pipelines and specialized pipelines are 6.2% and -0.8%, respectively, and the errors at other detection points are roughly the same. The accuracy of the specialized Y-type pipeline has significantly improved, reducing the impact of the pipeline on tidal volume calibration from more than 6% to less than 1%. The use of specialized pipelines can significantly improve the accuracy and qualification rate of calibration, reducing the consumption of disposable Y-type pipelines and thereby significantly reducing costs and increasing efficiency.

开发了一种专用的Y型管道,以取代医用一次性Y型管道进行呼吸机校准,并提高准确性,为改进提供参考。根据呼吸机的校准规范,对专用管道和更多管道进行测试,以比较其数据。以潮气量400mL检测点为例,医用一次性管道和专用管道的校准误差分别为6.2%和-0.8%,其他检测点的误差大致相同。专用Y型管道的精度显著提高,将管道对潮气量校准的影响从6%以上降低到1%以下。使用专用管道可以显著提高校准的准确性和合格率,减少一次性Y型管道的消耗,从而显著降低成本和提高效率。
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引用次数: 0
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Critical reviews in biomedical engineering
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