Cardiovascular Pathology最新文献

英文中文

Relationship between myocardial fibrosis and left bundle branch block. Does it exist? 心肌纤维化与左束支阻滞的关系。它存在吗？

IF 2.3 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Pathology

Pub Date : 2024-12-31 DOI: 10.1016/j.carpath.2024.107713

Elena Rimskaya , Olga Aparina , Olga Stukalova , Semen Kormilitsyn , Nataliia Mironova , Petr Chumachenko , Sergey Ternovoy , Sergey Golitsyn

Aim

to assess the relation of focal and diffuse left ventricular (LV) fibrosis to left bundle branch block (LBBB).

Materials and methods

60 patients with dilated cardiomyopathy and LBBB (DCM-LBBB), 50 DCM-nonLBBB patients, 15 patients with LBBB and structurally normal heart (idiopathic LBBB) and 10 healthy volunteers (HV) underwent cardiovascular magnetic resonance (CMR) with late gadolinium enhancement (LGE). LGE LV images were post-proceeded for core scar (CS) and gray zone (GZ) calculation. Diffuse LV fibrosis was estimated on LGE-CMR images with the diffuse intensity ratio (DIR). Endomyocardial biopsy (EMB) was performed in 15(24.6 %) DCM-LBBB and 16 (32 %) non-LBBB DCM patients and allowed the quantification of collagen volume fraction (CVF).

Results

The percentage of CVF correlated with the DIR value in the same segment (r = 0.66, p < 0.001). The value of CVF in EMB and frequency of LGE in both DCM groups was comparable (p = 0.8). In DCM-nonLBBB patients the percentage of CS was significantly higher (4.0[1.6; 11.7]% versus 1.4[0.1;8.5]% in DCM-LBBB patients, p = 0.047), whereas percentage of GZ and total fibrosis in both DCM groups was comparable. DIR value was higher in patients with idiopathic LBBB than in HV (0.54±0.09 versus 0.34±0.1, р<0,001).

Conclusion

Neither focal nor interstitial fibrosis is associated with LBBB in DCM patients. Diffuse inflammation in DCM-LBBB patients may contribute to the progression of systolic dysfunction but is not a cause of LBBB. The increased value of interstitial fibrosis in patients with idiopathic LBBB may reflect latent diffuse process in myocardium inexorably leading to DCM development.

目的：探讨局灶性和弥漫性左室纤维化与左束支传导阻滞的关系。材料与方法：60例扩张型心肌病合并LBBB （DCM-LBBB）、50例dcm -非LBBB、15例LBBB合并结构正常（特发性LBBB）和10例健康志愿者（HV）行心血管磁共振（CMR）晚期钆增强（LGE）。LGE LV图像为核心疤痕（CS）和灰色区域（GZ）计算的后处理。弥漫性左室纤维化在LGE-CMR图像上用弥漫性强度比（DIR）估计。15例（24.6%）DCM- lbbb患者和16例（32%）非lbbb DCM患者进行了心内膜心肌活检（EMB），并允许胶原体积分数（CVF）的量化。结果：CVF百分比与同一节段的DIR值相关（r=0.66, p）。结论：局灶性（包括中壁条纹）和间质性纤维化与DCM患者的LBBB无关。DCM-LBBB患者的弥漫性炎症可能有助于收缩功能障碍的进展，但不是LBBB的原因。LBBB患者间质纤维化值升高可能反映了心肌的潜伏弥漫性过程不可避免地导致DCM的发展。

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引用次数: 0

Tocilizumab does not ameliorate inflammation-induced left ventricular dysfunction in a collagen-induced arthritis rat model 在胶原诱导的关节炎大鼠模型中，Tocilizumab不能改善炎症诱导的左心室功能障碍。

IF 2.3 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Pathology

Pub Date : 2024-12-27 DOI: 10.1016/j.carpath.2024.107711

Ashmeetha Manilall , Lebogang Mokotedi , Sulè Gunter , Regina Le Roux , Serena Fourie , Aletta ME Millen

Background

Interleukin-6 (IL-6) is an attractive therapeutic target due to its diverse roles in the pathogenesis of conditions characterized by systemic inflammation. IL-6 has also been implicated in the pathophysiology of heart failure. This study aimed to investigate the impact of IL-6 receptor blockade with tocilizumab on the molecular pathways underlying systemic inflammation-induced left ventricular (LV) dysfunction in a collagen-induced arthritis (CIA) rat model.

Methods

Seventy-three Sprague-Dawley rats were divided into three groups: control (n=28), CIA (n=29), and CIA+IL-6 blocker (n=16). Inflammation was induced in the CIA and CIA+IL-6 blocker groups using bovine type II collagen emulsified in incomplete Freund's adjuvant. After arthritis onset, the CIA+IL-6 blocker group received tocilizumab for six weeks. Circulating inflammatory markers, relative LV mRNA gene expressions, and LV systolic and diastolic function were assessed.

Results

CIA rats developed LV diastolic and early-stage LV systolic dysfunction, which was not ameliorated by IL-6 blocker administration (p > 0.05). IL-6 blocker administration did not impact circulating inflammatory markers (all p > 0.05) or LV mRNA expression of inflammatory markers compared to the CIA group, nor did it reverse inflammation-induced increases in LV mRNA expression of genes involved in fibrosis and collagen turnover, regulation of titin phosphorylation, Ca²⁺ handling, mitochondrial function, or apoptosis (all p > 0.05). However, LV mRNA expressions of CD68 and LOX, genes involved in macrophage infiltration and collagen cross-linking, were increased in the CIA group (p = 0.03, p = 0.0004), but not in the CIA+IL-6 blocker group compared to controls (p > 0.05).

Conclusion

These results suggest that although IL-6 blockade by tocilizumab may prevent inflammation-induced collagen cross-linking, the current treatment regimen may not protect against inflammation-induced LV dysfunction. Therefore, the role of IL-6 in the molecular mechanisms of inflammation-induced LV dysfunction remains inconclusive.

背景：白细胞介素-6（IL-6）在以全身炎症为特征的疾病的发病机制中发挥着多种作用，因此是一个极具吸引力的治疗靶点。IL-6 也与心力衰竭的病理生理学有关。本研究旨在探讨托西珠单抗阻断IL-6受体对胶原诱发关节炎（CIA）大鼠模型中全身炎症诱发左心室（LV）功能障碍的分子通路的影响：73只Sprague-Dawley大鼠分为三组：对照组（n=28）、CIA组（n=29）和CIA+IL-6受体阻滞剂组（n=16）。CIA组和CIA+IL-6阻断剂组使用在不完全弗氏佐剂中乳化的牛Ⅱ型胶原蛋白诱发炎症。关节炎发病后，CIA+IL-6 阻断剂组接受了为期六周的托珠单抗治疗。对循环炎症标志物、左心室 mRNA 基因的相对表达以及左心室收缩和舒张功能进行了评估：结果：CIA大鼠出现了左心室舒张功能障碍和早期左心室收缩功能障碍，但服用IL-6受体阻滞剂并没有改善这些症状（p > 0.05）。与 CIA 组相比，IL-6 阻滞剂不会影响循环炎症标志物（所有 p > 0.05）或左心室炎症标志物 mRNA 的表达，也不会逆转炎症诱导的左心室 mRNA 表达增加，这些基因涉及纤维化和胶原周转、滴定蛋白磷酸化调节、Ca2+ 处理、线粒体功能或细胞凋亡（所有 p > 0.05）。然而，与对照组相比，CIA 组参与巨噬细胞浸润和胶原交联的基因 CD68 和 LOX 的 LV mRNA 表达增加（p = 0.03，p = 0.0004），但 CIA+IL-6 阻断剂组没有增加（p > 0.05）：这些结果表明，虽然托西珠单抗阻断IL-6可防止炎症诱导的胶原交联，但目前的治疗方案可能无法防止炎症诱导的左心室功能障碍。因此，IL-6在炎症诱导的左心室功能障碍的分子机制中的作用仍无定论。

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引用次数: 0

Corrigendum to “Comparative evaluation of local and downstream responses in two commercially available paclitaxel-coated balloons in healthy peripheral arteries of a swine model” “两种市售紫杉醇包覆气球在猪模型健康外周动脉内局部和下游反应的比较评价”的更正。

IF 2.3 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Pathology

Pub Date : 2024-12-18 DOI: 10.1016/j.carpath.2024.107710

María Gracia de Garnica García , Laura Mola Mola Solà , Claudia Pérez-Martínez , Luis Duocastella Codina , María Molina Crisol , Alex Gómez Castel , Armando Pérez de Prado

引用次数: 0

Takayasu arteritis with medio-medial intussusception? 高须动脉炎伴中-内侧肠套叠？

IF 2.3 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Pathology

Pub Date : 2024-11-30 DOI: 10.1016/j.carpath.2024.107709

Pradeep Vaideeswar , Pranav Bhatia , Bharati Malankar

We present an autopsy case of a child with Takayasu arteritis who succumbed due to cerebrovascular accident with an interesting finding in the inflamed aorta. On account of necro-inflammatory changes in the media of the distal descending thoracic aorta coupled with the shear stress of accelerated hypertension, there was a medial detachment, which migrated and lay between the intima and media of the abdominal aorta. This displacement was visualized on gross and histopathological examination as a ‘laminated’ appearance of coils of discontinuous inflamed tunica media, reminiscent of a hydatid cyst, which has been designated as medio-medial intussusceptions.

我们呈报一例因脑血管意外而死于高须动脉炎的儿童的尸体解剖，并在其发炎的主动脉中发现了一个有趣的发现。由于远段胸降主动脉中膜的坏死-炎症改变，加上高血压加速的剪切应力，出现内侧脱离，它迁移并位于腹主动脉内膜和中膜之间。在大体和组织病理学检查中，这种移位表现为不连续的炎症中膜线圈的“层状”外观，使人联想到包虫囊肿，已被指定为中内侧肠套叠。

引用次数: 0

COVER 4: Table of Contents/Barcode PMS 200 封面 4：目录/条形码 PMS 200

IF 2.3 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Pathology

Pub Date : 2024-11-21 DOI: 10.1016/S1054-8807(24)00104-2

引用次数: 0

COVER 3: Editorial Board 封面 3：编辑委员会

IF 2.3 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Pathology

Pub Date : 2024-11-21 DOI: 10.1016/S1054-8807(24)00103-0

引用次数: 0

Giant cell aortitis combined with arteritis and coarctation of the aorta in 3.5-month child: A case report and literature review 3 个半月大的婴儿患巨细胞主动脉炎合并动脉炎和主动脉共动脉症：病例报告和文献综述。

IF 2.3 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Pathology

Pub Date : 2024-11-05 DOI: 10.1016/j.carpath.2024.107703

Yuliia Kuzyk, Dmytro Zerbino, Olga Kovalyk

A present case showing giant cell aortitis (GGA) with coarctation of the aorta can be considered unique, even after reviewing the literature. The case of a 3.5-month-old girl who suffered an acute viral infection with an increase in body temperature (up to 39.5°C), difficulty breathing, and diarrhea is described. The girl was diagnosed with nasopharyngitis, enterocolitis, meningoencephalitis; she died 20 hours after being hospitalized from multiple organ failure. Clinical and laboratory data were collected, and a pathological examination was performed. Histological examination of the aorta and its main branches, such as the brachiocephalic trunk, left common carotid artery, left subclavian artery, as well as internal organs, was performed using hematoxylin-eosin, Hart's resorcin-fuchsin, Weigert's picrofuchsin, and Masson's trichrome. Pathological examination revealed giant cell aortitis and arteritis with coarctation of the aorta. GCA, in our case, had pathomorphological signs. First, many plaques that protruded into the lumen of the aorta and main branches, such as the brachiocephalic trunk, left common carotid artery and left subclavian artery, had a conical end that resembled the appearance of a rash. Second, granulomatous inflammation was localized in the intima of the aorta and all layers of the above-mentioned arteries.

Our case of GCA in a 3.5-month-old girl is the youngest patient among those described. We first describe GCA in relation to other severe aortic diseases. Coarctation, in combination with an aneurysm of the ascending aorta and aortitis, is a pathology that has not yet been described.

本病例显示巨细胞性主动脉炎（GGA）伴有主动脉共动脉症，这在查阅文献后也被认为是独一无二的。本病例描述的是一名 3 个半月大的女童，因急性病毒感染导致体温升高（高达 39.5°C）、呼吸困难和腹泻。女童被诊断为鼻咽炎、小肠结肠炎和脑膜脑炎；住院 20 小时后死于多器官衰竭。收集了临床和实验室数据，并进行了病理检查。使用苏木精-伊红、Hart'sresorcin-fuchsin、Weigert's picrofuchsin和Masson's trichrome对主动脉及其主要分支（如肱脑干、左颈总动脉、左锁骨下动脉）以及内脏器官进行了组织学检查。病理检查显示，患者患有巨细胞主动脉炎和动脉炎，并伴有主动脉粥样硬化。在我们的病例中，GCA 具有病理形态学特征。首先，许多突入主动脉和主要分支（如肱动脉干、左颈总动脉和左锁骨下动脉）管腔的斑块末端呈圆锥形，外观类似皮疹。其次，肉芽肿性炎症位于主动脉内膜和上述动脉的各层。我们的病例是一名 3.5 个月大的女童，她的 GCA 是所描述病例中年龄最小的患者。我们首先介绍 GCA 与其他严重主动脉疾病的关系。主动脉粥样硬化合并升主动脉瘤和主动脉炎是一种尚未被描述过的病理现象。

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引用次数: 0

Cause of death for heart transplant patients, an autopsy study 心脏移植患者的死因，一项尸检研究。

IF 2.3 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Pathology

Pub Date : 2024-10-16 DOI: 10.1016/j.carpath.2024.107701

Justin Burk, Cory T. Bernadt, Jon Ritter, Chieh-Yu Lin

Introduction

Heart transplantations are lifesaving for patients with end-stage heart failure. It is pertinent for the multidisciplinary care team to understand how heart transplant patients succumbed to death and the complications that occurred. In this study, we performed a comprehensive retrospective review of all the autopsies performed in our institute for heart transplant patients and report the trend of demographic data, cause of death, and autopsy findings.

Materials and methods

Reports, photos, and slides of autopsies performed at our institute from 1990 to 2023 for heart transplant patients were reviewed. Pertinent demographic data (age, gender, pretransplant diagnosis), clinical data (clinical history of rejection, complication, time interval from transplant to death, clinical cause of death) and pathological findings (allograft pathology, infectious etiology, other findings related to cause of death) were reviewed, documented, and analyzed.

Results

We identified 88 cases, consisting of 53 male and 35 female patients. The median age at transplant was 26 years, while 28.5 years was the median age at death. The median interval from transplant to death was 10 months. The cases were classified in three categories based on length of survival post-transplant: Superacute (<1 month, 21%), Early (1 month-12 months, 30%), and Late (> 12 months, 49%). Slides were unavailable for review in 15 cases, which were excluded from cause of death (COD) evaluation. We categorized 41.1% of cases as allograft-related COD and 58.9% as non-allograft-related COD. Six of the CODs were not perceived premortem. These unexpected CODs included moderate/severe acute cellular rejection in a patient with a recently negative biopsy, dehiscent suture caused by a fungal abscess, an aorto-bronchial fistula, CMV myocarditis, acute abdominal bleeding, and ruptured atherosclerotic plaques with acute myocardial infarction.

Conclusion

We systematically reviewed 33 years of heart transplant autopsies. We found that 41.1% of deaths were allograft related, with infection being the most frequent COD. While the rate of unexpected findings was low, the findings demonstrate the continued utility of autopsy in patient evaluation.

导言心脏移植可挽救终末期心力衰竭患者的生命。对于多学科护理团队来说，了解心脏移植患者的死亡原因和发生的并发症非常重要。在这项研究中，我们对本研究所为心脏移植患者进行的所有尸检进行了全面的回顾性审查，并报告了人口统计学数据、死亡原因和尸检结果的趋势：对 1990-2023 年期间在我院进行的心脏移植患者尸检报告、照片和切片进行了回顾。对相关人口统计学数据（年龄、性别、移植前诊断）、临床数据（排斥反应临床病史、并发症、从移植到死亡的时间间隔、临床死因）和病理结果（异体移植病理、感染性病因、与死因相关的其他结果）进行了回顾、记录和分析：结果：我们共发现 88 例患者，其中男性 53 例，女性 35 例。移植时的中位年龄为 26 岁，死亡时的中位年龄为 28.5 岁。从移植到死亡的中位间隔为 10 个月。根据移植后存活时间的长短，病例被分为三类：超急性期（12 个月，占 49%）。有 15 例病例的切片无法送检，这些病例被排除在死因（COD）评估之外。我们将 41.1% 的病例归类为异体移植相关死因，58.9% 归类为非异体移植相关死因。其中有六例死前未发现死因。这些意外的COD包括近期活检阴性的患者出现中度/重度急性细胞排斥反应、真菌脓肿引起的缝线开裂、支气管主动脉瘘、CMV心肌炎、急性腹腔出血以及动脉粥样硬化斑块破裂伴急性心肌梗死：我们对三十三年来的心脏移植尸检进行了系统回顾。结论：我们系统回顾了三十三年来的心脏移植尸检，发现41.1%的死亡与异体移植有关，其中感染是最常见的COD。虽然意外发现的比例较低，但这些发现表明尸检在患者评估中仍有用武之地。

{"title":"Cause of death for heart transplant patients, an autopsy study","authors":"Justin Burk, Cory T. Bernadt, Jon Ritter, Chieh-Yu Lin","doi":"10.1016/j.carpath.2024.107701","DOIUrl":"10.1016/j.carpath.2024.107701","url":null,"abstract":"<div><h3>Introduction</h3><div>Heart transplantations are lifesaving for patients with end-stage heart failure. It is pertinent for the multidisciplinary care team to understand how heart transplant patients succumbed to death and the complications that occurred. In this study, we performed a comprehensive retrospective review of all the autopsies performed in our institute for heart transplant patients and report the trend of demographic data, cause of death, and autopsy findings.</div></div><div><h3>Materials and methods</h3><div>Reports, photos, and slides of autopsies performed at our institute from 1990 to 2023 for heart transplant patients were reviewed. Pertinent demographic data (age, gender, pretransplant diagnosis), clinical data (clinical history of rejection, complication, time interval from transplant to death, clinical cause of death) and pathological findings (allograft pathology, infectious etiology, other findings related to cause of death) were reviewed, documented, and analyzed.</div></div><div><h3>Results</h3><div>We identified 88 cases, consisting of 53 male and 35 female patients. The median age at transplant was 26 years, while 28.5 years was the median age at death. The median interval from transplant to death was 10 months. The cases were classified in three categories based on length of survival post-transplant: Superacute (<1 month, 21%), Early (1 month-12 months, 30%), and Late (> 12 months, 49%). Slides were unavailable for review in 15 cases, which were excluded from cause of death (COD) evaluation. We categorized 41.1% of cases as allograft-related COD and 58.9% as non-allograft-related COD. Six of the CODs were not perceived premortem. These unexpected CODs included moderate/severe acute cellular rejection in a patient with a recently negative biopsy, dehiscent suture caused by a fungal abscess, an aorto-bronchial fistula, CMV myocarditis, acute abdominal bleeding, and ruptured atherosclerotic plaques with acute myocardial infarction.</div></div><div><h3>Conclusion</h3><div>We systematically reviewed 33 years of heart transplant autopsies. We found that 41.1% of deaths were allograft related, with infection being the most frequent COD. While the rate of unexpected findings was low, the findings demonstrate the continued utility of autopsy in patient evaluation.</div></div>","PeriodicalId":9451,"journal":{"name":"Cardiovascular Pathology","volume":"74 ","pages":"Article 107701"},"PeriodicalIF":2.3,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interplay of atherosclerosis and medial degeneration in human ascending aorta 人体升主动脉中动脉粥样硬化和内侧变性的相互作用。

IF 2.3 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Pathology

Pub Date : 2024-10-09 DOI: 10.1016/j.carpath.2024.107702

Aaron Huhta , Timo Paavonen , Ari Mennander , Ivana Kholová

The previous understanding has been that atherosclerosis tends to increase distally from the ascending aorta, but recent studies and practical experience have indicated that atherosclerosis occurs in the ascending aorta more than previously thought. Medial degeneration is linked to aortic aneurysms, dissection and dilatation and has been related to increased mortality. There is a lack of data on the coexistence of atherosclerosis and medial degeneration in the ascending aorta and its outcome to clinical morbidity and mortality. Earlier studies have shown coexisting atherosclerosis and medial degeneration as significant risk indicators for coronary and cerebrovascular events. We aimed to analyze aortic specimens classified according to the consensus documents of the Society for Cardiovascular Pathology and the Association for European Cardiovascular Pathology particularly the comparison of variable morphological features with the atherosclerotic grade to gain more data about the coexistence of atherosclerosis and medial degeneration. We evaluated 217 specimens of human ascending aorta resected at Tampere University Heart Hospital because of aortic aneurysm, dissection or dilatation. None of the samples contained normal aortic morphology; atherosclerosis was found in a total of 75.8 % of the samples and medial degeneration in all the samples. The present study is mostly in agreement with earlier research regarding the prevalence of different histological findings, even though a higher prevalence of atherosclerosis was found compared with most studies. There was no statistically significant association between atherosclerosis and medial degeneration, but a higher atherosclerotic grade was significantly associated with the presence of smooth muscle cell nuclei loss, smooth muscle cell disorganisation, elastic fibre thinning and medial fibrosis. Our study reinforces the perception that atherosclerotic lesions significantly occur in the ascending aorta and coexist with individual components of the medial degeneration.

以往的认识是，动脉粥样硬化往往从升主动脉向远端加重，但最近的研究和实践经验表明，动脉粥样硬化发生在升主动脉的情况比以前想象的要多。内侧变性与主动脉瘤、夹层和扩张有关，并与死亡率增加有关。目前还缺乏升主动脉动脉粥样硬化和内侧变性并存及其对临床发病率和死亡率影响的数据。早期研究表明，动脉粥样硬化和内侧变性并存是冠心病和脑血管事件的重要风险指标。我们的目的是分析根据心血管病学协会和欧洲心血管病学协会共识文件分类的主动脉标本，特别是比较可变形态特征与动脉粥样硬化等级，以获得更多有关动脉粥样硬化和内侧变性并存的数据。我们评估了坦佩雷大学心脏医院因主动脉瘤、夹层或扩张而切除的 217 例人体升主动脉标本。所有标本中没有一个具有正常的主动脉形态；75.8%的标本中发现了动脉粥样硬化，所有标本中都发现了内侧变性。尽管与大多数研究相比，本研究发现动脉粥样硬化的发生率更高，但在不同组织学结果的发生率方面，本研究与之前的研究基本一致。动脉粥样硬化与内侧变性之间没有统计学意义上的显著关联，但动脉粥样硬化等级越高，平滑肌细胞核缺失、平滑肌细胞紊乱、弹性纤维变细和内侧纤维化越明显。我们的研究强化了这样一种观点，即动脉粥样硬化病变明显发生在升主动脉，并与内侧变性的各个组成部分共存。

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引用次数: 0

Sudden cardiac death caused by Kawasaki coronary artery vasculitis in a child with Hodgkin's lymphoma. Case report and literature review 一名霍奇金淋巴瘤患儿因川崎冠状动脉血管炎导致心脏猝死。病例报告和文献综述。

IF 2.3 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Pathology

Pub Date : 2024-10-05 DOI: 10.1016/j.carpath.2024.107700

Cecilia Salzillo , Monica De Gaspari , Cristina Basso , Mariantonietta Francavilla , Francesco De Leonardis , Andrea Marzullo

Coronary artery vasculitis is a rare pathological condition and is often a manifestation of systemic vasculitis, such as Polyarteritis Nodosa, Kawasaki Disease, Takayasu Arteritis, and Giant Cell Arteritis, with Kawasaki Disease being the most common cause in children.

We present the autopsy case of a 6-year-old boy with classic Hodgkin lymphoma who died of sudden cardiac death due to thrombosis caused by vasculitis, which exclusively affected the coronary arteries and was suggestive of Kawasaki Disease.

To further investigate the histological features of Kawasaki Disease across all age groups, we conducted a literature review using the search terms “Kawasaki AND vasculitis AND histopathology” and “Kawasaki vasculitis histopathology” in Scopus, Google Scholar, and PubMed, covering the period from 1967 to 2023.

The inclusion criteria were as follows: coronary histology (inflammation and/or aneurysm and/or thrombosis), postmortem studies, English language, free articles, all age groups, case reports, and case series.

冠状动脉血管炎是一种罕见的病理状态，通常是结节性多动脉炎、川崎病、高安动脉炎和巨细胞动脉炎等全身性血管炎的一种表现，其中川崎病是儿童中最常见的病因。我们报告了一例患有典型霍奇金淋巴瘤的 6 岁男孩的尸检病例，他死于脉管炎引起的血栓形成导致的心脏性猝死，血栓形成仅累及冠状动脉，并提示为川崎病。为了进一步研究川崎病各年龄组的组织学特征，我们在 Scopus、Google Scholar 和 PubMed 中使用 "川崎和血管炎和组织病理学 "和 "川崎血管炎组织病理学 "进行了文献综述，时间跨度为 1967 年至 2023 年。纳入标准如下：冠状动脉组织学（炎症和/或动脉瘤和/或血栓形成）、死后研究、英语、免费文章、所有年龄组、病例报告和系列病例。

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