Cancer Epidemiology and Prevention Biomarkers最新文献

{"title":"Abstract B16: Development of breast cancer risk prediction for the UK population using the UK Biobank dataset","authors":"K. Alajmi, A. Lophatananon, K. Muir","doi":"10.1158/1538-7755.CARISK16-B16","DOIUrl":"https://doi.org/10.1158/1538-7755.CARISK16-B16","url":null,"abstract":"Breast cancer is the most common female cancer and is the second most common cause of cancer death among females. The UK has the highest age standardised incidence and mortality rates in the world, with two in every 1000 women aged 50 and above developing breast cancer annually. Several risk prediction models have been developed to estimate the likelihood for developing breast cancer based on specific risk factors in currently healthy individuals within a specific period of time. The available models are derived principally from either genetic or non-genetic factors. The majority of these models are however not user-friendly, do not focus on modifiable factors entirely and are not specifically designed for the general public. Our research group is developing an individualised risk prediction model for breast cancer focusing on the modifiable risk factors using the UK Biobank data. A nested case-control study within the 273,467 female participants is being used to develop the model. We have split the data into training and testing sets and will carry out all statistical tests to ensure our model calibrates well. For model validation, we will further seek external validation cohorts. The model will provide risk scores derived from the presence or absence of specific risk factors and will be compared to the general public score. The model will allow people to modify their risk profile with appropriate prevention measures. The main goal of the model is to be used in cancer education and prevention. The results from exploratory analyses suggested positive associations between breast cancer risk and age, breast cancer family history, menopause age, age at first child, BMI, height, null-parity, smoking, alcohol intake, and family history of other cancer. An algorithmic model will be developed based on these factors. We will also evaluate public perceptions using focus group technique. We will be presenting the results of the model development from the training set and the results of the internal validation from the testing set. In conclusion, we are developing an individualised breast cancer risk prediction model for the UK population based on the modifiable risk factors. The model will enable us to educate and to design appropriate interventions tailored to the individual with the aim of assisting them to make appropriate changes to modify their cancer risk profile. Citation Format: Kawthar Alajmi, Artitaya Lophatananon, Kenneth Muir. Development of breast cancer risk prediction for the UK population using the UK Biobank dataset. [abstract]. In: Proceedings of the AACR Special Conference: Improving Cancer Risk Prediction for Prevention and Early Detection; Nov 16-19, 2016; Orlando, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2017;26(5 Suppl):Abstract nr B16.","PeriodicalId":9487,"journal":{"name":"Cancer Epidemiology and Prevention Biomarkers","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90744712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstract B07: Two-pore domain potassium (K+) channel genes and triple-negative (TN) subtype in The Cancer Genome Atlas (TCGA) breast cancer dataset","authors":"K. Dookeran, Maria Argos","doi":"10.1158/1538-7755.DISP16-B07","DOIUrl":"https://doi.org/10.1158/1538-7755.DISP16-B07","url":null,"abstract":"Introduction: The family of 2-pore domain K+ (K2P) channel genes has 15 members, are background channels which enable the leak of K+ ions from cells, and are considered to be important for baseline activity of cells at rest including membrane potential, calcium homeostasis and volume regulation. Prior studies support the hypothesis that alterations of expression or function of K2P channels in cancer cells may play a significant role in tumor development and progression. In the vast majority of tumors, the abnormally expressed channel is wild type. The role of K2P channel genes in breast cancer is currently emerging. A recent microarray database study suggests that all but 5 K2P gene family members showed altered expression in breast cancer. Other studies suggest potential clinical utility of K2P channel genes as biomarkers associated with TN subtype. A weighted gene co-expression network analysis study showed that upregulation of KCNK5 was associated with poor outcome for TN related tumors. TN tumors are also known to occur more frequently in women of non-Hispanic (nH) black race and association between black race and unique KCNK4 and KCNK9 breast tumor methylation patterns have been suggested; KCNK9 association with TN subtype has also been observed. However, there is a paucity of studies characterizing K2P genes in clinical breast cancer, and the goal of our study was the systematic evaluation of the relationship between K2P gene DNA methylation/expression and TN breast tumor subtype, in the large publically available TCGA dataset. Methods: TCGA invasive breast cancer data was available for 1040 women of which 767 had Illumina HM450 methylation beta-values and 959 had RSEM mRNA expression z-scores (single values from level 3 data). We evaluated the direction and association of all K2P gene expression/methylation loci and TN subtype using age and race adjusted glm models. Age and race adjusted Cox models were used for analysis of disease free (DFS) and overall survival (OS). CpG methylation loci within 25kb from either end of the genes of interest were included for examination (UCSC genome browser, hg37). A total of 724 CG loci were included using this approach, but after exclusion of probes with null reads, the number of loci available for study was reduced to 608. Methylation glm model results were sorted on p-values (smallest to largest) and the top 10 associated loci were selected for reporting and further analysis. Selected loci were then checked for functionality related to expression using Spearman9s correlation. Bonferroni corrected p-values were used where appropriate. Results: Overexpression of KCNK5, KCNK9, KCNK10 and KCNK12, and underexpression of KCNK6 and KCNK15, were significantly associated with TN subtype (all p Conclusions: TN subtype is associated with specific K2P channel gene over and underexpression patterns, and similar expression patterns observed in blacks is consistent with more frequent TN disease. Our findings also su","PeriodicalId":9487,"journal":{"name":"Cancer Epidemiology and Prevention Biomarkers","volume":"834 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75065974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstract C67: Colorectal cancer screening in rural and frontier communities: The FluFIT on the Frontera Project","authors":"T. Hurd, Cecilia Lozano, S. Sotelo, Samantha Adame, R. Rodriguez, Hector Guerra, T. Sunil","doi":"10.1158/1538-7755.DISP16-C67","DOIUrl":"https://doi.org/10.1158/1538-7755.DISP16-C67","url":null,"abstract":"The prevalence of colorectal cancer screening among people living in Texas-Mexico, rural/frontier Border communities and colonias is not well characterized. While colorectal cancer screening in the Border region is 30%, among Hispanics, FOBT screening in the prior 2 years is 9.4%, and 59% of screening eligible adults have never had endoscopy (Texas BRFSS 2010). The FluFIT on the Frontera project, a colorectal cancer screening project for average risk people, was adapted from the evidence based FluFIT curriculum and implemented in a rural/frontier community setting to increase colorectal cancer screening. The project provides education, screening, early detection and treatment through community and regional partnerships. It targets Hispanic and underserved men and women aged 50-75 years of age who reside in the rural/frontier communities of Del Rio Texas and the surrounding colonias. Methods Clinic based providers and certified male and female promotores from Val Verde Regional Medical Center and QUAD Counties Promotoras Program, respectively, received formal didactic and implementation training for the FluFIT intervention. Participants received colorectal cancer screening education and FluFIT test process instruction from trained staff in the clinical setting and promotores in the community setting. Clinic and community based navigators provided participant navigation to insure timely receipt of specimens for analysis and follow-up. Participants who did not have a primary care provider were assigned to a provider in the Val Verde Regional Medical Center primary care clinic. All test results were provided to participants by either their assigned or private primary care providers. An integrated clinic and community based provider, navigator and project partnership assured referral for appropriate services as needed for positive tests. Results In the first 7 months of community programming 3743 community members were educated in either group or individual settings. Of these, 1959 adults (789 males, 40%; 1170 females) aged 50-75 years were evaluated for screening. Seventy five percent self-identified as white Hispanic and 25% as non-Hispanic. 753 met the screening eligibility criteria and 1206 did not. Of 753 (38.4%) who were screening eligible, 563 (74.8%) received FIT kits. Among 342 kits (60.7%) that were returned, 14 (12.57%) were positive. Colonoscopy was completed in 79% of patients with a positive FIT test and polyps were identified in 7. No cancers were diagnosed. Average and high risk participants accounted for 58.8% and 41.2% of people who were ineligible for screening. Among ineligible average risk participants 659 (80.3%) had prior screening. Among 575 high risk patients, 199 (34.6%) reported no prior screening. Prior screening accounted for 74.1% of participant ineligibility overall irrespective of risk stratification. Conclusions The FluFIT intervention is being successfully implemented in a rural/frontier community. The high proportion","PeriodicalId":9487,"journal":{"name":"Cancer Epidemiology and Prevention Biomarkers","volume":"81 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73724880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstract C84: Utilization of cervical cancer screening services by women living with HIV enrolled in primary care at the Moore Clinic of Johns Hopkins Hospital: A 10-year retrospective cohort study","authors":"S. Peprah, J. Coleman, A. Rositch, C. VandenBussche, Richard D. Moore, Amber M D'Souza","doi":"10.1158/1538-7755.DISP16-C84","DOIUrl":"https://doi.org/10.1158/1538-7755.DISP16-C84","url":null,"abstract":"Background: Due to their compromised immune function, which elevates their risk of disease, women living with HIV (WLWH) represent an important high-risk subgroup for cervical precancer and cancer. However, there is limited information on cervical cancer screening utilization by WLWH in the current antiretroviral treatment era. This retrospective cohort study explores frequency of screening, screening intervals, and the risk factors associated with utilization of cervical cancer screening services by 544 WLWH enrolled in clinical care for at least 18 months at Johns Hopkins between 2005-2014. Understanding utilization and the significant factors associated with underscreening of WLWH, can inform interventions to improve screening adherence in this high-risk group. Methods: Pap tests, clinical and socio-demographic covariates were obtained by merging a pathology database with a clinical cohort database. The primary outcome of interest was the receipt of Pap testing in the study period. Frequency of screening and screening intervals were described from study entry (defined as first clinic visit after January 1, 2005) to exit (December 31, 2014 or last time seen at Johns Hopkins). Results: The cohort was primarily black (79%), median age of 41 years (IQR: 34-48) and median follow-up of 5.7 years (IQR: 3.7-7.9). At entry, median CD4 count and HIV viral load were 307 cells/ul (IQR: 510-127), and 7712 copies/ml (IQR: 400-53693) respectively. Current smoking (57%), injection drug use (26%) and obesity or overweight (48.5%) were all common at entry. A substantial proportion of these women (21%) were never screened during the study, despite being in care. Median follow-up among these never-screened women was 4.7 years (IQR: 3.2-6.3). Among the 79% of women who were screened at least once, there was variation in frequency of screening. Some of these women received only one (21%), or two (18%) Pap tests, while others had three (15%), four (13%) and five or more (32%) Pap tests. Among this group of ever-screened participants, the median interval between Pap tests was 11.3 months (IQR: 6.2-17.2). Women who only had one Pap during the study had a much longer average time from entry to Pap (49.5 months, IQR: 18.4-62.4), than the time between Pap tests for women who had 2,3, 4, and 5 or more Pap tests (17.6, 14.8, 12.4, 10.1 months, respectively), p Conclusion: These findings enhance our knowledge of cervical cancer screening utilization among a high-risk group of HIV-infected, primarily minority, women. They demonstrate that in spite of the recommendation for annual cervical cancer screening of WLWH, even when enrolled in clinical care, some WLWH are not screened. Citation Format: Sally Peprah, Jenell Coleman, Anne Rositch, Christopher VandenBussche, Richard Moore, Amber D9Souza. Utilization of cervical cancer screening services by women living with HIV enrolled in primary care at the Moore Clinic of Johns Hopkins Hospital: A 10-year retrospective cohort study.","PeriodicalId":9487,"journal":{"name":"Cancer Epidemiology and Prevention Biomarkers","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77942363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstract PR5: Prognostic value of miRNAs in breast cancer: Molecular type and patient race","authors":"B. K. Putcha, Trafina Jadhav, Shantel Hébert‐Magee, J. Bae, A. Frost, I. Eltoum, S. Bae, U. Manne","doi":"10.1158/1538-7755.DISP13-PR5","DOIUrl":"https://doi.org/10.1158/1538-7755.DISP13-PR5","url":null,"abstract":"Background: MicroRNAs (miRNAs) are a class of conserved, non-coding RNAs that are dysregulated in various cancers, including breast cancers. The potential of miRNAs to serve as biomarkers for breast cancer diagnosis and prognosis is being explored, but their clinical value based on race/ethnicity and molecular subtypes (luminal and triple negative breast cancers, TNBCs) has not been examined. Thus, we evaluated expression levels of a panel of miRNAs in luminal (A and B) breast cancers and TNBCs of African Americans (Blacks) and non-Hispanic Caucasians (Whites). We further evaluated the prognostic value of miRNAs based on molecular type of breast cancer and patient race. Methods: TaqMan® miRNA assays were used to quantify expression of miR-181a, miR181b, miR-21, miR-106a, miR-155, miR-210, miR-335, miR-206, and miR-126 in 105 breast cancers (luminal=51 and TNBCs=54) and their corresponding benign/normal tissues. Cancer tissuefrom 48 Blacks (luminal=23 and TNBCs=25) and 57 Whites (luminal=28 and TNBC=29) were analyzed. Fold change in the expression levels between tumor-normal pairs were determined using the 2-∆∆Ct method. A cutoff value for each miRNA was determined by utilizing the Cutoff Finder software application [PLoS ONE 7(12):e51862, 2012]. The cutoff values were used to categorize the tumors into two groups (High expression or positive and low expression or negative). The expression status of tumors was correlated with patient overall survival by univariate Kaplan-Meier analysis. Results: Since the survival probabilities of Blacks and Whites with TNBCs (log rank, p=0.899) were similar, TNBCs from both racial groups were pooled. Similarly, no survival differences were noted in patients of both racial groups with luminal breast cancers (log rank, p=0.178). Therefore, luminal cancers of Blacks and Whites were also pooled together to perform survival analyses based on miRNA expression levels. MiRNA expression profiling studies indicated that, in both the racial groups, miR-181a, miR-181b, miR-21, miR-106a, miR-155, and miR-210 were up-regulated in luminal cancers and TNBCs. In contrast, miR-335, miR-206, and miR-126 were down-regulated in both molecular types. When the prognostic value of miRNAs was evaluated in each molecular type separately, it was found that over-expression of miR-106a (p=0.037) and miR-210 (p=0.039) were associated with poor prognosis of TNBCs. However, none of the evaluated miRNAs were useful in assessing the prognosis of patients with luminal cancers. Conclusions: These findings suggest that increased expression of miR-106a and miR-210 were poor prognostic indicators of TNBCs collected from both Black and White patients. Additionally, our results suggest that in the evaluation of clinical utility of miRNAs molecular types of breast cancer should be considered. This study was funded in part by the National Cancer Institute of the National Institute of Health UAB/TU/MSM Partnership grant (U54 CA118948). This abstract is als","PeriodicalId":9487,"journal":{"name":"Cancer Epidemiology and Prevention Biomarkers","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73571739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstract B66: Utilizing communication preferences for smoking cessation with Native Hawaiian Pacific Islanders","authors":"P. Palmer, S. Tanjasiri, Cevadne Lee, Vanessa May, Tupou Toilolo, K. Pang, D. Vaivao, Annette Orne, J. Lepule, M. Sabado, J. Pike, S. Cen, B. Xie","doi":"10.1158/1538-7755.DISP13-B66","DOIUrl":"https://doi.org/10.1158/1538-7755.DISP13-B66","url":null,"abstract":"Despite a general decline in cigarette smoking in the U.S., Native Hawaiian Pacific Islanders (NHPIs) experience higher prevalence rates and tobacco-related morbidity and mortality than most other ethnic groups. To inform the development of a theory-driven smoking cessation intervention for NHPI young adults, a group at high risk for progression to nicotine addiction, community researchers from five NHPI-led community-based organizations (CBOs) along with academic researchers collaborated on a community-based participatory research (CBPR) pilot study. Of 64 participating current smokers from 18 to 29 years of age, 61% were male, 76.6% were born on the U.S. Mainland, and 81.2% self identified as either Tongan or Samoan. Completion of high school/GED was the highest level of education for 58.1%, 25.8% had some college or post-high school training, and 6.5% completed a 2-year and 6.5% a 4-year college degree. Among participants, 44.3% were unemployed, 53.2% had no health insurance, and 50.9% could not afford medical care. Past month daily smoking was reported by 74.6%, 35.5% reported heavy intermittent smoking at least 20 days in the past month, 79.7% smoked menthol cigarettes, and 53.2% smoked more than 11 cigarettes daily. Past quit attempts had failed for 82.8%, 75% had tried to quit without a program or support, and 65.1% intend to try to quit in the next year. In terms of communication preferences, 93.8% had access to the internet and 79.7% could access a computer at least 4 days per week. While 46.9% had landline phone access, 93.8% had cell phones, and 93.7% felt confident using smart phones. With regard to social media and video site use, 92.7% reported using online social networking sites (sometimes to very often) with Facebook (95%), Twitter (44%), and YouTube (98.4%) the most frequently used sites. A summary of findings revealed high unemployment, relatively low education, and limited access to medical services for most, in addition to moderate to high cigarette use, past failed quit attempts, lack of cessation program support, high intention to quit, and familiarity with and high use of various communication modes. Guided by pilot results and CBPR processes, our smoking cessation program comprises: 1) an 8-module online curriculum with tobacco use education, quit tips, and maintenance strategies; 2) supportive and motivational text messages, 3) an internal online social support forum for participants to blog their challenges and successes, and 4) a weekly text/phone contact for participants with program staff. Given Facebook9s high use, we have provided components 1-3 through a Facebook App designed expressly for the program. In addition, recruitment videos and quit smoking scenarios in the curriculum are available through YouTube. Facebook is also being used for broad advertisement of the intervention study in the NHPI community. Smoking cessation strategies for NHPI young adults should utilize design components and methods of delivery ","PeriodicalId":9487,"journal":{"name":"Cancer Epidemiology and Prevention Biomarkers","volume":"187 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74429747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Race and Risk of Large Bowel Polyps in Younger and Older Patients","authors":"Kristin Wallace, D. Ahnen, C. Burke, Elizabeth L. Barry, R. Bresalier, F. Saibil, J. Baron","doi":"10.1158/1055-9965.EPI-12-0092","DOIUrl":"https://doi.org/10.1158/1055-9965.EPI-12-0092","url":null,"abstract":"African Americans (AA) have a higher incidence of colorectal cancer (CRC) compared to European Americans (EA). However, AA are consistently diagnosed with CRC at a younger age suggesting a possible biologic difference in neoplasms by race. Few studies have investigated racial differences in risk of","PeriodicalId":9487,"journal":{"name":"Cancer Epidemiology and Prevention Biomarkers","volume":"17 1","pages":"566-566"},"PeriodicalIF":0.0,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82023100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived Risk and Worry For One's Partner and Self Correlate With Desire to Quit in Dual-Smoker Couples","authors":"K. Ranby, Megan A. Lewis, B. Toll, M. Rohrbaugh, I. Lipkus","doi":"10.1158/1055-9965.EPI-12-0080","DOIUrl":"https://doi.org/10.1158/1055-9965.EPI-12-0080","url":null,"abstract":"Among smokers, the desire to quit smoking is often related to one9s health concerns. However, much less is known about how perceptions of health concerns are related in couples in which both partners smoke (i.e., dual smoker couples) and their associations with desire to quit for self. We explored these issues using baseline survey data collected from 63 dual smoker couples recruited from the community in central North Carolina. Participants were aged 21 to 67 (M = 43.0, SD = 11.3) and had been smoking for 4 to 51 years (M = 22.9, SD = 11.3) with an average of 17 (SD = 8.8) cigarettes per day. Within couples, partners exhibited similar beliefs about worry about physical harm of smoking for oneself (r = .30, p","PeriodicalId":9487,"journal":{"name":"Cancer Epidemiology and Prevention Biomarkers","volume":"12 1","pages":"561-561"},"PeriodicalIF":0.0,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82912950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lifestyle and Dietary Risk Factors for Colorectal Hyperplastic and Adenomatous Polyps","authors":"S. Michal, L. Li, Z. Chen","doi":"10.1158/1055-9965.EPI-12-0084","DOIUrl":"https://doi.org/10.1158/1055-9965.EPI-12-0084","url":null,"abstract":"Background: Increasing evidence suggests that colon hyperplastic polyps (HP) increases predisposition to the development of colon cancer, albeit to a lesser degree than colon adenoma. Data on behavioral and lifestyle risk factors for HP are limited.\u0000\u0000Methods: We compared the risk factor profiles for colon adenoma and colon HP in 1,826 patients without known history of colorectal cancer or polyps who are undergoing screening colonoscopy at our institution. Five hundred and eight patients were diagnosed with one or more colon adenomas, 215 with HP, 140 patients with both adenoma and HP, and 963 with negative colonscopic examination. Information on behavioral and lifestyle risk factors and dietary habits were collected by computer-assisted personal interview (CAPI) and Food Frequency Questionnaire prior to colonoscopy. We used multivariate unconditional logistic regressions to assess risk associations.\u0000\u0000Results: Positive association were found between adenomatous polyps and male gender (OR 1.702, 95% CI 1.210–2.394, p 0.002), current smoker (OR 1.598, 95% CI 1.091–2.340, p 0.016) and family history (OR 1.409, 95% CI 1.034–1.920, p 0.030). For hyperplastic polyps, positive associations were found between current smoker (OR 2.038, 95% CI 1.207–3.441, p 0.008) and regular alcohol drinker (OR 1.661, 95% CI 1.057–2.610, p 0.028). For both types of polyps positive associations were found between male gender (OR 2.282, 95% CI 1.233–4.222, p 0.009), current smoker (OR 2.692, 95% CI 1.475–4.912, p 0.001) and family history (OR 2.472, 95% CI 1.506–4.057, p 0.00). In a subgroup analysis by gender, regular alcohol consumption (OR 1.780, 95% CI 1.008–3.143, p 0.047) was associated with increased risk and HRT (OR 0.450, 95% CI 0.225–0.903, p 0.025) was associated with a decreased risk of hyperplastic polyps in females. Whereas in males, ever smokers (OR 3.074, 95% CI 1.357–6.965, p 0.007) and current smokers (OR 3.311, 95% CI 1.307–8.389, p 0.012) were associated with an increase risk of hyperplastic polyps.\u0000\u0000Conclusion: Our data indicate that there are several lifestyle and dietary risk factors that are associated with both colorectal adenomatous and hyperplastic polyps. These risk factors vary not only by type of polyp but also gender.\u0000\u0000This abstract is one of the 20 highest scoring abstracts of those submitted for presentation at the 36th Annual ASPO meeting held March 4–6, 2012, in Washington, DC.","PeriodicalId":9487,"journal":{"name":"Cancer Epidemiology and Prevention Biomarkers","volume":"40 1","pages":"563-563"},"PeriodicalIF":0.0,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86568910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tobacco Addiction and The Risk of Upper Aerodigestive Tract Cancer in A Multicenter Case-Control Study","authors":"Y. Lee, M. Marron, S. Benhamou, C. Bouchardy, W. Ahrens, H. Pohlabeln, P. Lagiou, D. Trichopoulos, A. Agudo, X. Castellsagué, Bencko, I. Holcatova, K. Kjaerheim, F. Merletti, L. Richiardi, G. Macfarlane, T. Macfarlane, R. Talamini, L. Barzan, C. Canova, L. Simonato, D. Conway, P. McKinney, P. Thomson, A. Znaor, C. Healy, B. McCartan, P. Boffetta, P. Brennan, M. Hashibe","doi":"10.1158/1055-9965.EPI-12-0079","DOIUrl":"https://doi.org/10.1158/1055-9965.EPI-12-0079","url":null,"abstract":"Background: While previous studies on tobacco and alcohol and the risk of upper aerodigestive tract (UADT) cancers have clearly shown dose-response relations with the frequency and duration of tobacco and/or alcohol, studies on addiction to tobacco itself as a risk factor for UADT cancer have not been published, to our knowledge. The aim of this report is to assess whether smoking addiction is a risk factor for UADT SCC risk in the multicenter case-control study (ARCAGE) in Western Europe independent of tobacco smoking or alcohol drinking intensity or duration.\u0000\u0000Methods: The analyses included 1,905 ever smoking UADT SCC cases (871 oral cavity/oropharynx, 814 hypopharynx/larynx, 127 esophagus, and 93 overlapping oral cavity/pharynx) and 1,489 ever smoking controls. The addiction variables included first cigarette after waking up, difficulty refraining from smoking in places where it is forbidden, and cigarettes per day. Odds ratios (OR) and 95% confidence intervals (95% CI) for UADT cancers with addiction variables were estimated with unconditional logistic regression, adjusting for center, age, sex, education level, alcohol consumption, and tobacco smoking.\u0000\u0000Results: Among current smokers, 76.47% of cases were categorized in the highest addiction level, whereas 54.69% of controls were in that category. The participants who smoked their first cigarette within 5 minutes of waking up were two times more likely to develop UADT SCC (OR = 2.22, 95% CI 1.57–3.15) than those who smoked 60 minutes after waking up. A higher modified Fagerstram score, reflecting greater tobacco addiction, was associated with an increased risk of UADT SCC among current smokers, but not among former smokers.\u0000\u0000Conclusion: We observed that time to first cigarette after waking up was associated with UADT SCC risk, regardless of heavy smoking or alcohol drinking behaviors. These results are consistent with residual effect of smoking that was not captured by the questionnaire responses alone. Cancer Epidemiol Biomarkers Prev; 21(3); 1–9. ©2012 AACR .","PeriodicalId":9487,"journal":{"name":"Cancer Epidemiology and Prevention Biomarkers","volume":"74 1","pages":"560-561"},"PeriodicalIF":0.0,"publicationDate":"2012-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75901208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}